Blister with second opening

Abstract

The present invention relates to a blister pack (1) for receiving one or more single doses of an agent (2), comprising at least one completely sealed cup (10) forming a dosing reservoir (100) for a single dose and having a circumferential rim (11). The blister pack (1) includes at least one first sealing film (12) that completely seals at least one first opening (101) on the rear side (102) of the at least one cup (10), forming the dosing reservoir (100) which is designed as a cavity containing the agent (2). The blister pack (1) according to the invention is characterized in that the at least one cup (10) has a second opening (104) on its front side (103) in its cup base (105) for dispensing the agent (2), which is completely sealed by means of a second sealing film (13), a sealing strip, or an adhesive strip arranged on the outside (1040) of the opening (104).

Description

Technical field

[0001] The present invention relates to a blister pack according to the preamble of claim 1. State of the art

[0002] Tablets or capsules are typically machine-blistered to protect them from environmental influences. To use these sealed dosage forms, the tablet / capsule is "squeezed" through the so-called release liner, which is usually thinner and therefore more brittle than the blister pack. This irreversibly destroys the blister pack, rendering it a single-use package.

[0003] Conventional blister packs for one or more single doses of a drug comprise a dosing reservoir containing a single dose, which is completely sealed and has a surrounding rim. These blisters are further covered with a sealing film (top film) that completely seals an opening on the back of the reservoir, forming a cavity containing the drug.

[0004] The lidding film is typically made of thin aluminum foil, which is used to hermetically seal the cups after the dosage forms have been inserted (gluing, crimping). For cost reasons, the cup film is usually made of plastic and, under heat and vacuum in the blister packaging machine, is "deep-drawn," meaning stretched into a depression. This creates cup-like recesses that can hold tablets or capsules. In cases where the medication needs to be protected from light and / or ambient moisture, both films are made of aluminum.

[0005] German patent application DE 10 2019 119 578 B1 describes an applicator and a method for sublimating a vaporizable veterinary medicinal product (dosing reservoir) in which a protective casing is depicted that is simultaneously used to heat the contents by means of electrical energy. This is intended to release suitable substances into the environment to exert their effect there (pharmaceuticals, biocides, pesticides, fragrances, etc.).

[0006] Release from the hermetically sealed dosage reservoir requires either a designated opening in the blister pack or that the pack opens due to internal pressure buildup, releasing the contents in a controlled manner. However, the latter release is uncontrolled, not targeted, and can lead to undesirable effects that make administering the dose difficult or even impossible. Description of the invention

[0007] The present invention is based on the objective of eliminating the aforementioned disadvantages and creating a blister pack that enables a targeted and controlled release of the contents from the dosing reservoir.

[0008] According to the invention, the aforementioned problem is solved according to the preamble of claim 1 in conjunction with the characterizing features. Advantageous embodiments and further developments of the blister according to the invention are specified in the dependent claims.

[0009] The blister according to the invention is characterized in that the at least one cup has a second opening on its front side in its cup base for dispensing a preferably evaporable agent (preferably a medicinal product), which is completely sealed by means of a second sealing film, a sealing strip or an adhesive strip arranged on the outside of the opening.

[0010] It is particularly advantageous that the second sealing film, sealing strip or adhesive strip is designed to be removable and is arranged on the bowl.

[0011] In a further advantageous embodiment of the invention, the second sealing film, sealing strip or adhesive strip is designed to tear and release the evaporated agent by applying pressure within the metering reservoir, which is achieved by heating the metering reservoir and the agent contained therein and its sublimation, or by heating another substance or mixture suitable for pressurization within the metering reservoir.

[0012] The second sealing foil or sealing strip can be, for example, an aluminum foil.

[0013] In an advantageous embodiment of the invention, the adhesive strip is a plastic film with an adhesive surface.

[0014] The first sealing film is preferably a plastic or aluminum foil that is inert up to about 200 °C, particularly preferably about 250 °C, i.e. temperature-resistant.

[0015] The second sealing film, sealing strip or adhesive strip is advantageously adhesive, tightly sealing and plastically melting at 60 to 90 °C.

[0016] In a further embodiment of the invention, the second sealing film, sealing strip or adhesive strip is preferably formed in such a way that the application of pressure causes a crack to form, which, analogous to a nozzle, causes the acceleration of the escaping gases.

[0017] For a directional and targeted release, the blister pack can be modified as follows, for example:

[0018] When forming the individual depressions (cups) of the blister packs, a hole with a defined diameter (2 to 10 mm in diameter) is punched into the base of the cup. To ensure protection from environmental influences during transport and storage of the blister contents, the punched hole can be sealed again.

[0019] There are preferably two options for this: 1) sealing with a suitable, permanently airtight adhesive strip, or 2) sealing with a temperature-sensitive but temperature-stable film that is applied. With the first option, the adhesive strip must be removed by the user before using the blister and the medication it contains, thus releasing the opening. With the second option, the film can remain in place before use. Due to heating and internal pressure, the film shrinks and releases the opening. By heating the blister with electrical energy, the contents of the blister can then be released from the opening without pressure.

[0020] This design allows for a targeted and controlled release of the contents from the dosing reservoir. This release can occur in any desired direction, for example, to administer a medication to a bee colony or, in a suitable device, to selectively release essential oils and distribute them into the surrounding area via a fan.

[0021] Closure options that ensure a moisture-proof seal:

[0022] Adhesive version: these self-adhesive closures can be applied by machine using a roller application: Aluminum foil with adhesive surface; plastic foil with adhesive surface;

[0023] Foil variant (moisture-proof, temperature-stable up to 200 °C and plastic from 80 °C); these foils are applied to the bottom of the tray during blister packaging by means of a shrink process under heat: Suitable plastic film inert up to 200 °C; natural materials, e.g., based on gelatin, agar-agar, or starch; brief description of the drawings

[0024] Further objectives, features, advantages and application possibilities of the blister according to the invention will become apparent from the following description of an exemplary embodiment with reference to the drawings.

[0025] The drawings show

[0026] Fig. 1 the blister according to the invention in an advantageous embodiment in a side view in cross-section;

[0027] Fig. 2 the blister according to the invention as in Fig. 1 in top view;

[0028] Fig. 3 the blister according to the invention as in Fig. 1 in the rear view. Implementation of the invention

[0029] As from Fig. 1 As can be seen, the second sealing film 13, the sealing strip or the adhesive strip comprises at least one peel-off strip 130 which does not adhere to the cup 10, which, in the closed state of the second opening 104, is designed or arranged to extend beyond the area of ​​the second sealing film 13, the sealing strip or the adhesive strip that adheres to the cup 10 and by means of which the sealing film 13, the sealing strip or the adhesive strip can be peeled off from the second opening 104.

[0030] The size of the second opening 104 is preferably 1 to 15 mm, particularly preferably 3 to 10 mm.

[0031] As from Fig. 2 As can be seen, the second opening 104 is preferably a hole punched into the bottom of the bowl 105.

[0032] As from Fig. 3 As can be seen, the blister 1 according to the invention advantageously comprises a heat source 14 by means of which the dosing reservoir 100 and / or the medium 2 contained therein (here a tablet, capsule or other medium) can be heated. The heat source 14 further preferably comprises an electrical resistor which is applied to and / or printed on the dosing reservoir 100 ( Fig. 3 ).

[0033] In a particularly advantageous embodiment of the invention, the second sealing film 13, the sealing strip or the adhesive strip can preferably be applied to the base of the tray 105 during blister packaging.

[0034] The application of the second sealing film 13, the sealing strips or the adhesive strips to the bottom of the cup 105 is advantageously carried out by gluing, shrinking or by another suitable method. List of reference numbers

[0035] 1 Blister 10 Bowl 11 Circumferential rim 12 First sealing film 13 Second sealing film 14 Heat source 100 Dosing reservoir 101 First opening 102 Back of bowl 103 Front of bowl 104 Second opening 105 Bowl base 130 Peel strip on the second sealing film 1040 Outside of the second opening

Claims

1. Blister (1) for receiving one or more single doses of an agent (2) with at least one completely sealed cup (10) forming a dosage reservoir (100) for a single dose and having a circumferential rim (11), wherein the blister (1) comprises at least one first sealing film (12) which completely seals at least one first opening (101) on the back (102) of the at least one cup (10) forming the dosage reservoir (100) which is designed as a cavity with the agent (2) embedded therein, characterized by the fact that which has at least one bowl (10) on its front (103) a second opening (104) in its bowl base (105) for dispensing the means (2), which is completely closed by means of a second sealing foil (13), a sealing strip or an adhesive strip arranged on the outside (1040) of the second opening (104).

2. Blister (1) according to claim 1, characterized by the fact thatthe second sealing film (13), the sealing strip or the adhesive strip is designed to be removable and is arranged on the cup (10).

3. Blister (1) according to claim 1 or 2, characterized by the fact that the second sealing film (13), the sealing strip or the adhesive strip is designed to tear and release the evaporated agent (2) by applying pressure within the metering reservoir (100), which is achieved by heating the metering reservoir (100) and the agent (2) contained therein and its sublimation, or by heating another substance or mixture suitable for pressurization within the metering reservoir (100).

4. Blister (1) according to one or more of the preceding claims, characterized by the fact that the second sealing foil (13) or sealing strip is an aluminum foil.

5. Blister (1) according to one or more of the preceding claims, characterized by the fact thatThe adhesive strip is a plastic film with an adhesive surface.

6. Blister (1) according to one or more of the preceding claims, characterized by the fact that the second sealing film (13), the sealing strip or the adhesive strip comprises at least one peel-off strip (130) which does not adhere to the cup (10) and which, in the closed state of the second opening (104), is formed or arranged to extend beyond the area of ​​the second sealing film (13), the sealing strip or the adhesive strip that adheres to the cup (10) and by means of which the sealing film (13), the sealing strip or the adhesive strip can be peeled off from the second opening (104).

7. Blister (1) according to one or more of the preceding claims, characterized by the fact that the first sealing film (12) is a plastic or aluminium film that is inert up to about 200 °C, preferably about 250 °C, i.e. temperature-resistant.

8. Blister (1) according to one or more of the preceding claims, characterized by the fact thatthe second sealing film (13), the sealing strip or the adhesive strip is adhesive, tightly sealing and plastically melting at 60 to 90 °C.

9. Blister (1) according to one or more of the preceding claims, characterized by the fact that the second sealing foil (13), the sealing strip or the adhesive strip is formed in such a way that the application of pressure causes a crack to form which, analogous to a nozzle, causes the acceleration of the escaping gases.

10. Blister (1) according to one or more of the preceding claims, characterized by the fact that the size of the second opening (104) is 1 to 15 mm, preferably 3 - 10 mm.

11. Blister (1) according to one or more of the preceding claims, characterized by the fact that the second opening (104) is a hole punched into the bottom of the bowl (105).

12. Blister (1) according to one or more of the preceding claims, characterized by the fact thatit comprises a heat source (14) by means of which the dosing reservoir (100) and / or the agent (2) contained therein can be heated.

13. Blister (1) according to claim 11, characterized by the fact that the heat source (14) comprises an electrical resistance which is applied and / or printed on the dosing reservoir (100).

14. Method for producing a blister (1) according to one or more of the preceding claims, characterized by the fact that the second sealing film (13), the sealing strip or the adhesive strip is applied to the bottom of the tray (105) during blister packaging.

15. Method for producing a blister (1) according to claim 14, characterized by the fact that the application of the second sealing film (13), the sealing strips or the adhesive strips to the bottom of the cup (105) is carried out by gluing, shrinking or by another suitable method.

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