System

Abstract

The present invention relates to novel systems, polypeptides, compounds and methods. The invention provides an inducible degron for target-specific protein degradation.

Description

[0001] SYSTEM Field of the Invention The present invention relates to novel systems, polypeptides, compounds and methods. The invention particularly provides an inducible degron for target-specific protein degradation. Background of the Invention Chemically induced degradation of proteins has emerged as a powerful complement to traditional, occupancy-based, small molecule therapeutics. This strategy allows all functions of a protein to be neutralized, including scaffolding roles and the action of undruggable domains, which would otherwise be difficult to inhibit. Within this approach, two distinct strategies have been developed to promote proteasomal protein degradation: proteolysis targeting chimeras (PROTACs) and molecular glues. PROTACs, bifunctional molecules that induce proximity between the target protein of interest (POI) and an E3 ligase to promote POI degradation, have progressed to the clinic as treatments for certain cancers. Alternatively, molecular glues are small molecules that bind to the surface of two proteins, enhancing or inducing their interaction. Molecules that function in this manner include the natural products cyclosporin, FK506, and rapamycin, and synthetic stabilizers of the hub protein 14-3-3 with its binding partners. The immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide exert their therapeutic action by stabilizing the interaction between the E3 ligase component cereblon (CRBN) and its zinc finger-containing neosubstrates, Ikaros family zinc finger protein 1 (IKZF1; Ikaros) and Ikaros family zinc finger protein 3 (IKZF3; Aiolos), resulting in the degradation of these proteins. Thalidomide-mediated degradation of the zinc finger-containing transcription factor spalt-like transcription factor 4 (SALL4), again through recruitment of CRBN, is responsible for the infamous teratogenicity caused by thalidomide; pomalidomide also effects degradation of SALL4, while lenalidomide is less effective in this regard. Recent work by Ichikawa et al. and Heim et al. has shown that IMiDs mimick the physiological substrates of CRBN, which comprise C-terminal cyclic imide post-translational modifications, that are formed by intramolecular cyclization of glutamine or asparagine residues. The zinc finger domains of IKZF1 and IKZF3 are examples of degrons, broadly defined as targeting signals that confer metabolic instability on some, or all, of the peptide bonds in a protein. This definition encompasses peptide sequences that enable substrate recognition by cognate E3 ubiquitin ligases, potentially after post-translational modification, and inducible degrons, which require the presence of a small molecule to promote protein degradation. The latter have been used as a complementary approach to PROTACs, allowing induced degradation of proteins of interest (POIs) that lack a small molecule ligand. Key examples of inducible degrons are HaloPROTACs, dTAG, and BromoTag. HaloPROTACs covalently attach a chloroalkane-linked E3 ligase ligand to a POI-HaloTag fusion resulting in recruitment of the E3 ligase, ubiquitination, and degradation of this fusion protein. The dTAG system employs a fusion of the POI to the FKBP12F36Vmutant. A bifunctional molecule comprising a selective FKBP12F36Vligand linked to a CRBN recruiter is used to induce degradation of the POI- FKBP12F36Vfusion protein. BromoTag works in a similar fashion, but employs the BRD4(2)L387Amutant fused to the POI. A bifunctional molecule comprising a JQ1-based ligand (AGB1) that binds selectively to BRD4(2)L387A, linked to a VHL ligand, is used to induce degradation of the POI-BRD4(2)L387Afusion protein. These technologies are powerful tools, but they all require the addition of relatively large protein domains to the POI, which has the potential to perturb the endogenous function of the POI. Zinc finger-based degrons offer an attractive alternative as inducible degrons, as the zinc finger motif typically comprises under 60 amino acids and will therefore minimally perturb the POI. Jan et al. employed mutant combinations of zinc finger motifs to identify super-degron tags that were degraded effectively by lenalidomide. These tags were attached to chimeric antigen receptors (CARs) to enable inducible degradation of the CAR in T-cell on the addition of lenalidomide. The combination of the degron-tagged CARs and lenalidomide functioned as an off switch to limit cytokine production while retaining antitumor effects. Carbonneau took a similar approach to develop a ligand-controlled CAR system using an IKZF3-based degron that was degraded upon addition of lenalidomide. While approaches such as these have shown some benefits in terms of overcoming the limitations of other inducible degrons by using the relatively small zinc-finger-based degron, problems remains. A particular issue in this regard is off-target degradation induced by the administered compounds. For example, Sievers et al. identified 11 zinc finger-containing transcription factors that were degraded in the presence of thalidomide, lenalidomide, or pomalidomide. Computational analysis suggested that more than 150 zinc fingers can bind to the drug-CRBN complex. Therefore, the use of IMiDs that can bind to the wild-type zinc finger degrons in CAR T-cell therapy, or target validation, risks degradation of additional neosubstrates leading to unwanted effects. The invention provides a revolutionary new system for combining a polypeptide and a modified IMiD that may function as an inducible degron without affecting other wild type degrons. The present invention may provide for i.a. reduced off-target effects and / or improved targeting, and, in therapeutic applications, may provide for reduced concentrations of therapeutic agents to be required in order to exert a desired therapeutic outcome, with benefits in terms of reduced toxicity, decreased costs, and / or improved patient compliance. Summary of the Invention The inventors have devised a novel principle of general application which combines a polypeptide degron and a modified IMiD compound for utilisation as an inducible degron. Advantageously, the present invention provides an inducible degron with improved specificity relative to known degron systems. Surprisingly, the present system can be utilised in cells without inducing the degradation of wild type degrons. This renders the system particularly suitable for use in clinical applications. The inventors have discovered novel polypeptides and novel compounds which together may form an orthogonal protein degradation system. The polypeptide degron can be attached to a protein of interest to selectively induce the degradation of the target protein in cells. To induce the degradation of the target protein of interest, the attached degron polypeptide is complexed with the novel compound which evokes a stable interaction between the E3 ligase component cereblon (CRBN) and the polypeptide. This interaction brings CRBN and the polypeptide into proximity with one another. Accordingly, CRBN catalyses polyubiquitination of the polypeptide which triggers the proteasomal degradation of the polypeptide and the target protein of interest that is attached to said polypeptide. Accordingly, the system provided herein allows unprecedented selectivity when seeking to induce the degradation of specific target proteins. This provides the user with the power to functionally characterise specific proteins without the occurrence of off-target effects. Furthermore, when applied to the clinic, the present invention allows the modulation of levels of specific proteins in genetically engineered cells without unwanted off-target effects. The invention provides a system, comprising: i) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2; and ii) a compound of Formula (A) [Formula A] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - X3is CHRDor C=O; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O- C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl. The invention further provides a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises (i) a modification at the position corresponding to Q147 of SEQ ID NO: 2; and (ii) a modification at one or more of the positions corresponding to N149, Q150 and S154 of SEQ ID NO: 2. The invention further provides a compound of Formula (B), [Formula B] wherein - X1is C-R1and X2is C-R2or N; or X1is C-R1or N and X2is C-R2; - X3is CHRDor C=O; - A: R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; or B: R1is selected from OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O- C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2 and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl. The invention further provides a method for degrading a target protein of interest in a cell, the method comprising: a) introducing a polynucleotide according to the invention, or a vector according to the invention into the cell such that the cell expresses the polypeptide attached to the target protein of interest; b) contacting the cell with a compound according to the invention; thereby inducing the degradation of the target protein of interest. The invention further provides a compound according to the invention for use in medicine. The invention further provides a method for identifying an orthogonal IMiD compound and polypeptide degron combination, the method comprising screening for increased binding affinity of one or more compounds according to the invention or as defined in the system of the invention against a polypeptide variant of SEQ ID NO: 2 or SEQ ID NO: 3 relative to a polypeptide sequence consisting of or comprising the polypeptide sequence of SEQ ID NO: 2 or SEQ ID NO: 3, thereby identifying an orthogonal IMiD compound and polypeptide degron combination. Brief Description of the Figures FIGURE 1. A. Endogenous neosubstrates IKZF1 and IKZF3 contain a conserved zinc finger region which confers sensitivity to degradation upon treatment with an IMID compound such as thalidomide (pictured). This region can be fused to a protein of interest (POI) to act as a degron; addition of an IMID will lead to degradation of the POI by the proteosome via recruitment of the ubiquitin E3 ligase cereblon. However, use of familiar IMIDs such as thalidomide, lenalidomide or pomalidomide will also lead to degradation of endogenous IKZF1 / IKZF3 B Akin to ‘bump-and’hole’ methodology, we synthesised IMIDs with additional chemical groups on the phthalimide ring and screened these against a library of modified zinc finger degrons, leading to the discovery of two novel, orthogonal IMID / degron systems, for which the IMID compounds do not degrade IKZF1 / IKZF3 even at high concentrations. C This region of crystal structure 6H0F shows the IMID pomalidomide acting as a molecular glue between cereblon (pink) and an IKZF1-derived zinc finger (grey) D A different angle of this region highlights the four residues around which our library is primarily based: Q147; N149; Q150; and S154. Q147 is the only ZF residue in direct contact with the IMID and is the most suitable candidate for mutation for the ‘bump-and-hole’ approach; the other residues were chosen for their proximity to residue 147 and the potential cereblon binding-enhancing effects mutation at these positions may convey. FIGURE 2. A. A plasmid containing a ZF degron fused to GFP in the same gene as mCherry. Jurkats that have been lentivirally transduced with this plasmid will express ZF-GFP and mCherry at a consistent ratio. B Addition of an IMID such as pomalidomide will induce GFP degradation via the degron’s functionality. C Incubation with an IMID produces a degradation curve. FIGURE 3. A Thalidomide, pomalidomide and a library of 34 other IMIDs were synthesised and screened against the wild-type IKZF1 / IKZF3 ZF degron sequence (WT) in jurkat cells (see figure 2 for assay description) to obtain pDC50 values. The same compound library was then screened against a single residue mutant ZF degron (Q147A) using the same technique to obtain a second set of pDC50 values. Rejecting all compounds with a Q147A DMax value >= 0.4, an orthogonality index value was given to each compound (10^(pDC50_Q147A / pDC50_WT)), where a value >10 indicates improved degradation of the Q147A mutant ZF B Two compounds in particular - A63 and B08 - can be seen to exhibit improved degradation against Q147A - evidence of the ‘bump-and-hole’ effect, as the smaller alanine residue accommodates the bulky group added to the thalidomide scaffold. C Orthogonality index values for all library compounds with Q147A Dmaxvalue <= 0.4. For reference, the 36 numbered compounds correspond to the IMID analogues depicted in Figure 10, and thus may thus alternatively be named herein according to their IMiD analogue names in Figure 10. The 36 numbered compounds and their corresponding IMiD analogue names are also set out as follows: FIGURE 4. A. Using crystal structure 6H0F, PositionScan functionality in Foldx and PositionMutation functionality in Rosetta were both used to assess impact of mutation at positions on the ZF in direct contact with cereblon: 149, 150, 153 and 167. Favourable mutations were only predicted at positions 149 and 150. Mutations which performed well in both softwares were chosen for our library (D, E and P for 149; I and V for 150) along with the WT residues (N for 149; Q for 150). B Our library - a total of 8,380 mutant ZFs - was synthesised in the same ZF-GFP-IRES-mCherry plasmid as used previously. The library was lentivirally transduced into Jurkat cells, ensuring a copy number of 1 per cell. The library population was incubated at an appropriate concentration of IMID, incubated overnight, then sorted by FACS to isolate low GFP cells. This, and the negative population, were sequenced and the ratio of each mutant in the positive and negative population used to determine level of degradation. C Volcano plots show ratio between negative and positive populations for each mutant (log2FC), with mutants overrepresented in the GFP-negative population appearing as ‘hits’. WT sequence is circled. Red points indicate mutants which were also ‘hits’ in a DMSO control FACS sort. D Average logFC for all mutants with different residues at position 147, all possible mutations at 149, 150 and 154 (included in the library), and all other positions same as WT. E Mean logFC for all mutants with different residues at 149 and 150, all possible mutations at 147 and 154 (included in the library), and all other positions same as WT. F Mean logFC for all mutants with different residues at 154, all possible mutations at 147, 149 and 150 (included in the library), and all other positions same as WT. FIGURE 5. Heat map showing LogFC values from library screen for mutants with all combinations of residues at 147 (all except P), 149 (D, E, N and P), 150 (I, Q and V) and 154 (all 20) after treatment with either thalidomide, A63 or B08. FIGURE 6. A Top performing mutants from the library screen (top 5 highest performing logFC values for A63 screen; 1st, 3rd and 4th highest scoring mutants for B08) were transduced into Jurkat cells and assessed using the same flow cytometry procedure as previously with their corresponding IMIDs to obtain pDC50values. Mutants are named after their residues at positions 147, 149, 150 and 154 (e.g. WT would be named QNQS) (all other residues are same as WT). Each IMID / mutant pair is assigned an orthogonality index value as in figure 3. B Graphical representation of orthogonality index values for top performing mutants for A63 and B08. The top performing mutant for A63 is AEVK and for B08 is WEIS C Concentration curves for flow cytometry assay confirms close to 100% degradation of the top mutant ZF-GFP at 10 μM for both A63 and B08. WT ZF-GFP is degraded 60-70%, in contrast to the endogenous IKZF3, which is unaffected relative to DMSO control at 1 μM or 10 μM for both A63 and B08 - as seen in D using Western blot analysis of untransduced Jurkat cells treated with pomalidomide, A63, B08. E Western blot for Jurkats transduced with AEVK-GFP shows full degradation of AEVK- GFP at 10 μM A63, while level of endogenous IKZF3 remains unaffected. FIGURE 7. 41 proposed compounds were docked into a region of crystal structure 6H0F in place of pomalidomide. Constrained docking in GOLD was used to hold the piperidine-2,6- dione component of the IMID inside the cereblon binding pocket, while allowing the phthalimide bicyclic ring and any group on position 4 or 5 to be flexible. Foldx was used to mutate position 147 on the zinc finger to all 20 amino acids, and GOLD allowed this residue to be flexible. The resulting ternary complex poses were then analysed using the scoring function from Autodock4 to provide a compound ranking. A particularly strong predicted pi-pi interaction between the benzyl group in thal_4_NH_CH2_C6H5 and tryptophan 147 in the Q147W ZF was detected using this screen. FIGURE 8. A A virtual library of thal_4_NH_CH2_C6H5 analogues was screened against the Q147W zinc finger in the same constrained docking protocol as described in figure 7, highlighting two modifications (ortho-methyl and 3-pyridyl) for which the difference in estimated binding energy between WT and Q147W is predicted to be the greatest (B). C The proposed binding pose for thal_4_NH_CH2_C6H5 docked into the cereblon / ZF binary complex (allowing the side chain of residue 147 to be flexible) clearly predicted a favourable pi-pi interaction between the R group of IMID and the side chain of W147. FIGURE 9. A The seven ZF degron residues chosen to scrutinise most thoroughly in the Jurkat library screen are shown: Q147 is proximal to the IMID and S154 interacts with Q147; N149 and Q150 are closed to the IMID; F146, A153 and F155 comprise the ‘hydrophobic core’ of the ZF motif. B The design of the ZF degron library is summarised: part 1 makes up the bulk of the library, where a full combinatorial exploration of choice mutations at positions 147, 149, 150 and 154 are explored, keeping all other residues the same as the WT ZF; part 2 explores subsections of the mutations seen in part 1, but with additional mutations to positions 146, 153 and 155; part 3 explores changes to 147 and a single change of residue 167 with all else being kept the same as the WT; part 4 is a single sequence where all is kept the same as WT except the glycine at 152. FIGURE 10. A 36 IMID analogues were screened against the WT ZF using a GFP / mCherry fluorescence flow cytometry assay to give degradation curves B The same 36 IMID analogues were screened in the same assay against a Q147A mutant degron to give new degradation curves. For reference, the 36 IMID analogues of Figure 10 may be alternatively named herein according to their corresponding compound no. 1 to 36 as follows: FIGURE 11. A 13 IMID analogues were incubated with unmodified Jurkat cells at different concentrations for 20 hours, after which cells were fixed and treated with IKZF1- specific antibody and analysed by flow cytometry. B Mutant ZF degron sequences with the highest logFC values from the A63 and B08 library screens were selected for individual analysis by the same GFP / mCherry assay as described in figure 10 along with others chosen for proof of concept. FIGURE 12. A Jurkat cells transduced with WT ZF-eGFP constructs were treated with pomalidomide at 1 nM, 10 nM or 100 nM for 20 hours, then Western Blots performed on the cell lysates. B Untransduced Jurkat cells were incubated with pomalidomide, A63 and B08 (all at 100 nM, 1μM or 10 μM) for 20 hours and Western Blots performed on the cell lysates. C Jurkat cells transduced with HEIP ZF-eGFP constructs were treated with A63 at 1nM, 10 nM, 100 nM, 1 μM or 10 μM for 20 hours, then Western Blots performed on the cell lysates. D Jurkat cells transduced with AEVK ZF-eGFP constructs were treated with A63 at 1 nM, 10 nM, 100 nM, 1 μM or 10 μM for 20 hours, then Western Blots performed on the cell lysates E Jurkat cells transduced with WEIS ZF-eGFP constructs were treated with B08 at 1 nM, 10 nM, 100 nM, 1 μM or 10 μM for 20 hours, then Western Blots performed on the cell lysates. FIGURE 13. Average fold enrichment and depletion of sequencing read counts and corresponding P values for sequences with raw read count >xxx following compound treatments. Three experimental replicates. WT sequence is circled. Red points indicate sequences significantly enriched following DMSO treatment. FIGURE 14. A Correlation of sorted positive and negative samples in the pooled library screen. B Limma-pi values of enriched degrons for each compound treatment in the pooled library screen. FIGURE 15. A schematic depicting a system combining a mutant degron polypeptide and a ‘bumped’ (i.e. modified) IMiD. The bumped IMiD cannot bind wild type degrons and therefore does not induce the degradation said wild type degrons. The bumped IMiD binds the mutant degron and CRBN and thereby indices the degradation of the mutant degron and any associated protein. FIGURE 16. Heat map shows LogFC values from library screen for mutants with all combinations of residues at stated positions of SEQ ID NO: 2 after treatment with either thalidomide, lenalidomide, as well as compounds 19, 22 and 23, relative to DMSO treatment. FIGURE 17. The 36 IMID analogues of Figure 10 reproduced wherein each compound is annotated with its compound number 1 to 36 and alternative name. FIGURE 18. Testing of four additional compounds, B22 (compound 37), B25 (compound 38), B31 (compound 39) and B32 (compound 40) as described in example 2. FIGURE 19. Testing of an additional compound C01 as described in example 3. Brief Description of the Sequences SEQ ID NO: 1 – polypeptide sequence FQCNQCGASF SEQ ID NO: 2 – IKZF3 polypeptide sequence MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEY SERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCI SFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGH LRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVL DRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEAL RPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGH DSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEV MDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK SEQ ID NO: 3 – IKZF1 polypeptide sequence MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSD EENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIG PNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHL RTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKI GSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAIN YLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPS EREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDA LRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRG EHRFHMS Detailed Description of the Invention The present invention will be described with respect to particular embodiments and with reference to certain drawings but the disclosure is not limited thereto but only by the claims. Any reference signs in the claims shall not be construed as limiting the scope. Of course, it is to be understood that not necessarily all aspects or advantages may be achieved in accordance with any particular embodiment. Thus, for example those skilled in the art will recognize that the disclosed embodiments may be embodied or carried out in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other aspects or advantages as may be taught or suggested herein. The disclosure, both as to organization and method of operation, together with features and advantages thereof, may best be understood by reference to the following detailed description when read in conjunction with the accompanying drawings. The aspects and advantages of the invention will be apparent from and elucidated with reference to the embodiment(s) described hereinafter. Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one disclosed embodiment. Thus, appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment, but may. Similarly, it should be appreciated that in the description of exemplary disclosed embodiments, various features are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various inventive aspects. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed invention requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment. It should be appreciated that “embodiments” of the disclosure can be specifically combined together unless the context indicates otherwise. The specific combinations of all disclosed embodiments (unless implied otherwise by the context) are further disclosed embodiments of the claimed invention. In addition as used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. Thus, for example, reference to “a polynucleotide” includes two or more polynucleotides, reference to “a protein” includes two or more proteins, and the like. "About" as used herein when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of ± 20 % or ± 10 %, more preferably ± 5 %, even more preferably ± 1 %, and still more preferably ± 0.1 % from the specified value, as such variations are appropriate to perform the disclosed methods. “Nucleotide sequence”, “DNA sequence” or “nucleic acid molecule(s)” as used herein refers to a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. This term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA, and RNA. The term “nucleic acid” as used herein, is a single or double stranded covalently-linked sequence of nucleotides in which the 3' and 5' ends on each nucleotide are joined by phosphodiester bonds. The polynucleotide may be made up of deoxyribonucleotide bases or ribonucleotide bases. Nucleic acids may be manufactured synthetically in vitro or isolated from natural sources. Nucleic acids may further include modified DNA or RNA, for example DNA or RNA that has been methylated, or RNA that has been subject to post-translational modification, for example 5’-capping with 7- methylguanosine, 3’-processing such as cleavage and polyadenylation, and splicing. Nucleic acids may also include synthetic nucleic acids (XNA), such as hexitol nucleic acid (HNA), cyclohexene nucleic acid (CeNA), threose nucleic acid (TNA), glycerol nucleic acid (GNA), locked nucleic acid (LNA) and peptide nucleic acid (PNA). The term “amino acid” in the context of the present disclosure is used in its broadest sense and is meant to include organic compounds containing amine (NH2) and carboxyl (COOH) functional groups, along with a side chain (e.g., a R group) specific to each amino acid. In some embodiments, the amino acids refer to naturally occurring L α-amino acids or residues. The commonly used one and three letter abbreviations for naturally occurring amino acids are used herein: A=Ala; C=Cys; D=Asp; E=Glu; F=Phe; G=Gly; H=His; I=Ile; K=Lys; L=Leu; M=Met; N=Asn; P=Pro; Q=Gln; R=Arg; S=Ser; T=Thr; V=Val; W=Trp; and Y=Tyr (Lehninger, A. L., (1975) Biochemistry, 2d ed., pp. 71-92, Worth Publishers, New York). The general term “amino acid” further includes D-amino acids, retro-inverso amino acids as well as chemically modified amino acids such as amino acid analogues, naturally occurring amino acids that are not usually incorporated into proteins such as norleucine, and chemically synthesised compounds having properties known in the art to be characteristic of an amino acid, such as β-amino acids. For example, analogues or mimetics of phenylalanine or proline, which allow the same conformational restriction of the peptide compounds as do natural Phe or Pro, are included within the definition of amino acid. Such analogues and mimetics are referred to herein as "functional equivalents" of the respective amino acid. Other examples of amino acids are listed by Roberts and Vellaccio, The Peptides: Analysis, Synthesis, Biology, Gross and Meiehofer, eds., Vol. 5 p. 341, Academic Press, Inc., N.Y. 1983, which is incorporated herein by reference. The terms “polypeptide”, and “peptide” are interchangeably used herein to refer to a polymer of amino acid residues and to variants and synthetic analogues of the same. Thus, these terms apply to amino acid polymers in which one or more amino acid residues is a synthetic non- naturally occurring amino acid, such as a chemical analogue of a corresponding naturally occurring amino acid, as well as to naturally-occurring amino acid polymers. Polypeptides can also undergo maturation or post-translational modification processes that may include, but are not limited to: glycosylation, proteolytic cleavage, lipidization, signal peptide cleavage, propeptide cleavage, phosphorylation, and such like. A peptide can be made using recombinant techniques, e.g., through the expression of a recombinant or synthetic polynucleotide. A recombinantly produced peptide is typically substantially free of culture medium, e.g., culture medium represents less than about 20 %, more preferably less than about 10 %, and most preferably less than about 5 % of the volume of the protein preparation. The term “protein” is used to describe a folded polypeptide having a secondary or tertiary structure. The protein may be composed of a single polypeptide, or may comprise multiple polypeptides that are assembled to form a multimer. The multimer may be a homooligomer, or a heterooligmer. The protein may be a naturally occurring, or wild type protein, or a modified, or non-naturally, occurring protein. The protein may, for example, differ from a wild type protein by the addition, substitution or deletion of one or more amino acids. A “variant” of a protein encompass peptides, oligopeptides, polypeptides, proteins and enzymes having amino acid substitutions, deletions and / or insertions relative to the unmodified or wild-type protein in question and having similar biological and functional activity as the unmodified protein from which they are derived. The term "amino acid identity" as used herein refers to the extent that sequences are identical on an amino acid-by-amino acid basis over a window of comparison. Thus, a "percentage of sequence identity" is calculated by comparing two optimally aligned sequences over the window of comparison, determining the number of positions at which the identical amino acid residue (e.g., Ala, Pro, Ser, Thr, Gly, Val, Leu, Ile, Phe, Tyr, Trp, Lys, Arg, His, Asp, Glu, Asn, Gln, Cys and Met) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. For all aspects and embodiments of the present invention, a “variant” has at least 50%, 60%, 70%, 80%, 90%, 95% or 99% complete sequence identity to the amino acid sequence of the corresponding wild-type protein. Sequence identity can also be to a fragment or portion of the full length polynucleotide or polypeptide. Hence, a sequence may have only 50 % overall sequence identity with a full length reference sequence, but a sequence of a particular region, domain or subunit could share 80 %, 90 %, or as much as 99 % sequence identity with the reference sequence. The term “wild-type” refers to a gene or gene product isolated from a naturally occurring source. A wild-type gene is that which is most frequently observed in a population and is thus arbitrarily designed the “normal” or “wild-type” form of the gene. In contrast, the term “modified”, “mutant” or “variant” refers to a gene or gene product that displays modifications in sequence (e.g., substitutions, truncations, or insertions), post-translational modifications and / or functional properties (e.g., altered characteristics) when compared to the wild-type gene or gene product. Methods for introducing or substituting naturally-occurring amino acids are well known in the art. For instance, methionine (M) may be substituted with arginine (R) by replacing the codon for methionine (ATG) with a codon for arginine (CGT) at the relevant position in a polynucleotide encoding the mutant monomer. Methods for introducing or substituting non- naturally-occurring amino acids are also well known in the art. For instance, non-naturally- occurring amino acids may be introduced by including synthetic aminoacyl-tRNAs in the IVTT system used to express the mutant monomer. Alternatively, they may be introduced by expressing the mutant monomer in E. coli that are auxotrophic for specific amino acids in the presence of synthetic (i.e. non-naturally-occurring) analogues of those specific amino acids. They may also be produced by naked ligation if the mutant monomer is produced using partial peptide synthesis. Conservative substitutions replace amino acids with other amino acids of similar chemical structure, similar chemical properties or similar side-chain volume. The amino acids introduced may have similar polarity, hydrophilicity, hydrophobicity, basicity, acidity, neutrality or charge to the amino acids they replace. Alternatively, the conservative substitution may introduce another amino acid that is aromatic or aliphatic in the place of a pre-existing aromatic or aliphatic amino acid. Conservative amino acid changes are well-known in the art and may be selected in accordance with the properties of the 20 main amino acids as defined in Table 6 below. Where amino acids have similar polarity, this can also be determined by reference to the hydropathy scale for amino acid side chains in Table 7. Table 6 - Chemical properties of amino acids Table 7 - Hydropathy scale __________________________________ Side Chain Hydropathy ______________________________________ Ile 4.5 Val 4.2 Leu 3.8 Phe 2.8 Cys 2.5 Met 1.9 Ala 1.8 Gly -0.4 Thr -0.7 Ser -0.8 Trp -0.9 Tyr -1.3 Pro -1.6 His -3.2 Glu -3.5 Gln -3.5 Asp -3.5 Asn -3.5 Lys -3.9 Arg -4.5 _______________________________________________ Unless otherwise indicated, nucleic acid sequences herein are written in the 5’-to-3’ direction from left to right. As used herein, a C1-6alkyl group is a linear or branched alkyl group containing from 1 to 6 carbon atoms. A C1-4alkyl group is a linear or branched alkyl group containing from 1 to 4 carbon atoms. A C1-4alkyl group is often a C1-3alkyl group or a C1-2alkyl group. Examples of C1-4alkyl groups include methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, and tert-butyl. A C1-2alkyl group is methyl or ethyl, typically methyl. For the avoidance of doubt, where two alkyl groups are present, the alkyl groups may be the same or different. As used herein, a C1-4alkoxy is a C1-4alkyl group as defined above joined to an oxygen atom. As used herein, a C2-6alkenyl group is a linear or branched alkyl group containing from 2 to 6 carbon atoms and having one or more, e.g. one or two, typically one double bonds. A C2-6alkenyl group is often a C2-4alkenyl group. Typically a C2-4alkenyl group is a C2-3alkenyl group. Examples of C2-4 alkenyl groups include ethenyl, propenyl and butenyl. As used herein, a C2-6alkynyl group is a linear or branched alkyl group containing from 2 to 6 carbon atoms and having one or more, e.g. one or two, typically one triple bonds. A C2-6alkynyl group is often a C2-4 alkynyl group. Typically a C2-4 alkynyl group is a C2-3 alkynyl group, for example ethynyl, propynyl or butynyl. An alkyl, alkoxy, alkenyl, or alkynyl group as used herein may be unsubstituted or substituted. Unless otherwise stated, substituted alkyl, alkoxy, alkenyl, or alkynyl groups typically carry one or more, e.g. 1, 2, 3 or 4, such as one, two or three e.g. one or two substituents. Preferred substituents include aryl, heteroaryl, heterocyclyl, alkoxy, amino and halogen substituents. The substituents on a substituted alkyl, alkoxy, alkenyl or alkynyl group are typically themselves unsubstituted unless otherwise stated. Where more than one substituent is present, these may be the same or different. As used herein, a halogen is typically chlorine, fluorine, bromine or iodine and is preferably chlorine, bromine or fluorine, especially chorine or fluorine, and most especially fluorine. Where a group or moiety is substituted with one or more halogen atoms, preferably it carries one, two, three or four halogen atoms, preferably one, two or three halogen atoms. Where a group or moiety is substituted with two or more halogen atoms, the halogen atoms may be the same or different. Typically, the halogen atoms are the same. As used herein a 6- to 10-membered aryl group is a substituted or unsubstituted, monocyclic or fused polycyclic aromatic group containing from 6 to 10 carbon atoms in the ring portion. Examples include monocyclic groups such as phenyl and fused bicyclic groups such as naphthyl and indenyl. Phenyl (benzene) is preferred. As used herein, a C6-10aryl group is typically a 6- to 10-membered aryl group as defined herein. As used herein, a 5- to 10-membered heteroaryl group is a substituted or unsubstituted, monocyclic aromatic group containing from 5 to 10 atoms in the ring portion, including at least one heteroatom, for example 1, 2 or 3 heteroatoms, typically selected from O, S and N; and is typically a 5- to 6- membered heteroaryl group which is a substituted or unsubstituted, monocyclic aromatic group containing 5 or 6 atoms in the ring portion, including at least one heteroatom, for example 1, 2 or 3 heteroatoms, typically selected from O, S and N. Examples of 5- and 6- membered heteroaryl groups include pyrrole, furan, thiophene, imidazole, oxazole, thiazole, pyridine, pyridazine, pyrimidine, and pyrazine. As used herein, a C5-10heteroaryl group is typically a 5- to 10-membered heteroaryl group as defined herein. As used herein, a C5-6heteroaryl group is typically a 5- to 6-membered heteroaryl group as defined herein. As used herein, a 5- to 10- membered heterocyclyl group is a cyclic group containing from 5 to 10 atoms selected from C, O, N and S in the ring, including at least one heteroatom, and typically one or two heteroatoms; and is typically a 5- to 8- membered heterocyclyl group, typically a 5- to 6- membered heterocyclyl group which is a cyclic group containing from 5 to 6 atoms selected from C, O, N and S in the ring, including at least one heteroatom, and typically one or two heteroatoms. The heteroatom or heteroatoms are typically selected from O, N, and S. A heterocyclic group may be saturated or partially unsaturated. A 5- to 6- membered partially unsaturated heterocyclic group is a cyclic group containing from 5 to 6 atoms selected from C, O, N and S in the ring and containing 1 or 2, e.g. 1 double bond. As used herein, a C5-10heterocyclyl group is typically a 5- to 10-membered heterocyclyl group as defined herein. As used herein, a C5-6heterocyclyl group is typically a 5- to 6-membered heterocyclyl group as defined herein. A 5- to 10- membered carbocyclyl group is a cyclic hydrocarbon containing from 5 to 10 carbon atoms. A carbocyclyl group may be saturated or partially unsaturated, but is typically saturated. A 5- to 10- membered partially unsaturated carbocyclyl group is a cyclic hydrocarbon containing from 5 to 10 carbon atoms and containing 1 or 2, e.g. 1 double bond. A 5- to 10- membered carbocyclyl group is typically a 5- to 8- membered carbocyclyl group such as a 5- to 6- membered carbocyclic group. Examples of 5- to 6- membered saturated carbocyclic groups include cyclopentyl and cyclohexyl groups. As used herein, a C5-10carbocyclyl group is typically a 5- to 10-membered carbocyclyl group as defined herein. As used herein, a C5-6carbocyclyl group is typically a 5- to 6-membered carbocyclyl group as defined herein. Examples of 5- to 6- membered saturated heterocyclic groups include piperazine, piperidine, morpholine, pyrrolidine, imidazolidine, and oxazolidine. Examples of 5- to 6- membered partially unsaturated heterocyclic groups include tetrahydropyrazine, tetrahydropyridine, dihydro-1,4-oxazine, tetrahydropyrimidine, dihydro-1,3-oxazine, dihydropyrrole, dihydroimidazole and dihydrooxazole. An aryl, heterocyclyl or heteroaryl group may be unsubstituted or substituted as described herein. For example, an aryl, heterocyclyl or heteroaryl group may be unsubstituted or substituted with 1, 2 or 3, typically 1 or 2 such as e.g. 1 substituent. Suitable substituents include alkyl group, alkoxyl groups, alkenyl groups, alkynyl groups, halogen, OH, and amino groups, which are typically themselves unsubstituted or substituted with one or more halogen atoms. As used herein, a pharmaceutically acceptable salt is a salt with a pharmaceutically acceptable acid or base. Pharmaceutically acceptable acids include both inorganic acids such as hydrochloric, sulphuric, phosphoric, diphosphoric, hydrobromic or nitric acid and organic acids such as oxalic, citric, fumaric, maleic, malic, ascorbic, succinic, tartaric, benzoic, acetic, methanesulphonic, ethanesulphonic, benzenesulphonic or p-toluenesulphonic acid. Pharmaceutically acceptable bases include alkali metal (e.g. sodium or potassium) and alkaline earth metal (e.g. calcium or magnesium) hydroxides and organic bases such as alkyl amines, aralkyl amines and heterocyclic amines. Preferred pharmaceutically acceptable salts are salts formed at the SO3H group with pharmaceutically acceptable bases, in particular quaternary ammonium salts e.g. tetrabutylammonium salts, or alkali metal salts, e.g. sodium or potassium salts, most preferably sodium salts. All publications, patents and patent applications cited herein, whether supra or infra, are hereby incorporated by reference in their entirety. System As explained in more detail herein, provided herein is a system. A system may for example be a biological system, a combination of components which may be produced, sold and distributed separately which together may optionally form a kit, or simply a combination of physical products. The system provided herein comprises a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, as described in more detail herein. The system further comprises a compound of Formula (A) as defined herein, preferably a compound of Formula (I) as defined herein. The system may comprise a mutant degron / IMID pair. In some embodiments the compound of formula (A) preferentially binds to the polypeptide. In some embodiments the compound of formula (A) preferentially binds to the polypeptide compared to the binding to native proteins in vivo, such as proteins of SEQ ID NO: 2 The system provided herein comprises: i) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2; and ii) a compound of Formula (A) [Formula A] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - X3is CHRDor C=O; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10- C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4 alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl. Preferably, the system provided herein comprises: i) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2; and ii) a compound of Formula (A) [Formula A] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - X3is CHRDor C=O; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10- C2-6alkynyl, C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10 aryl, C5-10 heteroaryl, C5-10 heterocyclyl, C5-10 carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or methyl. The compound of Formula (A) is preferably a compound of Formula (I): [Formula I] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10- C2-6alkynyl, C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2 and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2, or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl. The present inventors have determined that the system provided herein can function as an inducible degron system without affecting wild type degrons. A polypeptide according to the system provided herein, together with a compound of Formula (A) according to the system provided herein, therefore provides the system with a mode of action whereby proteins of interest can be specifically targeted for degradation whilst other proteins, including other degrons, are not targeted for degradation. Such a mode of action can be leveraged, for example, for experimental and therapeutic purposes. The specificity that can be achieved by the system means that off-target activity is minimised, and the potential for unwanted side-effects in a therapeutic setting is reduced. The polypeptide comprises a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2. SEQ ID NO: 1 corresponds to amino acids F146-F155 of the polypeptide sequence of IKZF3, which is defined according to SEQ ID NO: 2. Accordingly, in some embodiments the polypeptide comprises a variant of the amino acid sequence of SEQ ID NO: 2, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2. IKZF1 is comprised within the same Ikaros zinc finger family as IKZF3 and therefore shares a substantial degree sequence homology to IKZF3. F146-F155 of IKZF3 is identical to F145-F154 in IKZF1. SEQ ID NO: 1 therefore also corresponds to amino acids F145-F154 of the polypeptide sequence of IKZF1, which is defined according to SEQ ID NO: 3. The polypeptide may therefore alternatively comprise a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q146 of SEQ ID NO: 3. Accordingly, in some embodiments the polypeptide comprises a variant of the amino acid sequence of SEQ ID NO: 3, wherein the variant comprises a modification at the position corresponding to Q146 of SEQ ID NO: 3. Those skilled in the art will appreciate that the variant may be a variant defined according SEQ ID NO: 3 and thereby comprise modifications at the positions which correspond to the positions of SEQ ID NO: 2 disclosed herein. The variant of SEQ ID NO: 1 may be defined herein according SEQ ID NO: 2 or SEQ ID NO: 3. The variant may further comprise a modification at one or more of the positions corresponding to N149, Q150 and S154 of SEQ ID NO: 2. The variant preferably further comprises a modification at the position corresponding to N149 of SEQ ID NO: 2. The variant preferably further comprises a modification at the position corresponding to Q150 of SEQ ID NO: 2. The variant preferably further comprises a modification at the position corresponding to S154 of SEQ ID NO: 2. The variant more preferably further comprises a modification at the position corresponding to N149 and Q150 of SEQ ID NO: 2, N149 and S154 of SEQ ID NO: 2, or Q150 and S154 of SEQ ID NO: 2. The variant may alternatively further comprise modification at the positions corresponding to N149, Q150 and S154 of SEQ ID NO: 2. The aforementioned modifications have been defined relative to SEQ ID NO: 2. Those skilled in the art will appreciate that the variant may be a variant of SEQ ID NO: 2 and comprise the aforementioned modifications. The variant may be a variant of SEQ ID NO: 3 and comprise the aforementioned modifications relative to SEQ ID NO: 3; for example, the variant may comprise a modification at one or more of the positions corresponding to N148, Q149 and S153 of SEQ ID NO: 3. The variant may have at least about 50% sequence identity, 60% sequence identity, or preferably at least 70% sequence identity to SEQ ID NO: 1. Standard methods in the art may be used to determine homology. For example the UWGCG Package provides the BESTFIT program which can be used to calculate homology, for example used on its default settings (Devereux et al. (1984) Nucleic Acids Research 12, p387- 395). The PILEUP and BLAST algorithms can be used to calculate homology or line up sequences (such as identifying equivalent residues or corresponding sequences (typically on their default settings)), for example as described in Altschul S. F. (1993) J. Mol. Evol. 36:290-300; Altschul, S.F et al. (1990) J. Mol. Biol. 215:403-10. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (http: / / www.ncbi.nlm.nih.gov / ). The modification comprised in the variant may be any modification known in the art to alter the chemical properties of an amino acid at a specific position. The modification may particularly alter the chemical properties of the amino acid at the specific position such that the amino acid has different electrostatic or hydrophobic properties, such that its ability to chemical interact with a given compound of Formula (I) is changed. The modification is most preferably an amino acid substitution. The modification is preferably a conservative substitution as defined herein. In some embodiments the variant comprises Q147A / C / F / G / H / N / S / W / Y relative to SEQ ID NO: 2. Preferably, the modification Q147A / C / F / G / H / N / S / W / Y is Q147A / F / H / W. In some embodiments the variant comprises Q147A. In some embodiments the variant comprises Q147F. In some embodiments the variant comprises Q147H. In some embodiments the variant comprises Q147W. In some embodiments the variant comprises N149D / E / N / P relative to SEQ ID NO: 2 or 3 (preferably 2). Preferably the modification N149D / E / N / P is N149D / E. In some embodiments the variant comprises N149D. In some embodiments the variant comprises N149E. In some embodiments the variant comprises Q150I / Q / V relative to SEQ ID NO: 2 or 3 (preferably 2). In some embodiments the modification Q150I / Q / V is Q150I / V. In some embodiments the variant comprises Q150I. In some embodiments the variant comprises Q150V. In some embodiments the variant comprises S154A / C / E / F / G / H / I / K / L / M / N / P / Q / R / S / T / V / Y relative to SEQ ID NO: 2 or 3 (preferably 2). In some embodiments the modification S154A / C / E / F / G / H / I / K / L / M / N / P / Q / R / S / T / V / Y is S154K / P / Q / A. In some embodiments the variant comprises S154K. In some embodiments the variant comprises S154P. In some embodiments the variant comprises S154Q. In some embodiments the variant comprises S154A. In some embodiments the variant comprises A153F / H / R relative to SEQ ID NO: 2 or 3 (preferably 2). In some embodiment the variant comprises A153F. In some embodiments the variant comprises A153H. In some embodiments the variant comprises A153R. In some embodiments the variant comprises F146L relative to SEQ ID NO: 2. In some embodiments the variant comprises F155C relative to SEQ ID NO: 2. The aforementioned modifications may be combined in some embodiments. Accordingly, the variant may comprise one or more of the modifications: i) Q147A / C / F / G / H / N / S / W / Y relative to SEQ ID NO: 2, preferably Q147A / F / H / W; and / or ii) N149D / E / N / P relative to SEQ ID NO: 2; preferably N149D / E; and / or iii) Q150I / Q / V relative to SEQ ID NO: 2; preferably Q150I / V; and / or iv) S154A / C / E / F / G / H / I / K / L / M / N / P / Q / R / S / T / V / Y relative to SEQ ID NO: 2; preferably S154K / P / Q / A; and / or v) A153F / H / R relative to SEQ ID NO: 2; preferably A153F; and / or vi) F146L relative to SEQ ID NO: 2; and / or vii) F155C relative to SEQ ID NO: 2. The variant may comprise: - Q147H / N149E / Q150I / S154P relative to SEQ ID NO: 2; or - Q147F / N149E / Q150V / S154P; or - Q147W / N149E / Q150I / S154K; or - Q147F / N149D / Q150I / S154P; or - Q147A / N149E / Q150V / S154K; or - Q147W / N149E / Q150I; or - Q147W / Q150I / S154Q; or - Q147W / N149D / Q150I / S154A. The aforementioned modifications have been defined relative to SEQ ID NO: 2. As above, those skilled in the art will appreciate that the variant may comprise the corresponding modifications relative to SEQ ID NO: 3. Most preferably, the polypeptide forms a zinc-finger structural motif. The polypeptide may be at least 25 amino acids in length. The polypeptide is preferably, at least 30, 35, 40, 45, 50 or 55 amino acids in length. The polypeptide is most preferably at least 60 amino acids in length, preferably wherein the polypeptide comprises the amino acid sequence defined by positions 130-189 of SEQ ID NO: 2 except wherein the F145-F154 positions are defined according to the variant of the invention described herein. The polypeptide may have at least about 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity to SEQ ID NO: 2 or 3. The identity may be determined relative to the entire sequence of SEQ ID NOs 2 or 3. Or for example the identity may be determined over a sequence of 60 or more, 70 or more, 80 or more, 90 or more, 100 or more, 110 or more, 120 or more, 130 or more, 140 or more, or 150 or more contiguous amino acids comprised within SEQ ID NOs 2 and 3. Said contiguous amino acid sequence within SEQ ID NOs 2 and 3 preferably comprises the polypeptide defined according to SEQ ID NO: 1, and further preferably forms a zinc-finger structural motif. The polypeptide is preferably capable of binding a compound of Formula (A), preferably a compound of Formula (I). More preferably, the binding of said polypeptide to the compound of Formula (A) or Formula (I) is stronger than the binding of the polypeptide defined according to SEQ ID NO: 2 or SEQ ID NO: 3 to said compound of Formula (A) or Formula (I). Preferably, the binding of said polypeptide to the compound of Formula (A) or Formula (I) is at least about 1.25x, 1.5x, 2x, 3x, 4x, 5x, 10x, or 100x stronger than the binding of the polypeptide defined according to SEQ ID NO: 2 or SEQ ID NO: 3 to said compound of Formula (A) or Formula (I). Preferably, the relative affinities of the polypeptide defined according to the invention herein and the polypeptides according to SEQ ID Nos: 2 and 3 are quantified by the same assays. The binding assay used to quantify said the binding of said polypeptides to said compound of Formula (A) or Formula (I) may be any suitable protein-compound binding assays known in the art, wherein such assays may include computational in silico assays. Additionally, or alternatively, the polypeptide may have a reduced ability to bind one or more of thalidomide, lenalidomide, pomalidomide, avadomide and iverdomide when compared to the polypeptide defined according to SEQ ID NO: 2 or SEQ ID NO: 3. More preferably, the polypeptide may have a reduced ability to bind all of thalidomide, lenalidomide, pomalidomide, avadomide and iverdomide when compared to the polypeptide defined according to SEQ ID NO: 2 or SEQ ID NO: 3. Preferably, the polypeptide may have at least about a 2.5%, 5%, 10%, 25%, or 50% reduced ability to bind one or more of thalidomide, lenalidomide, pomalidomide, avadomide and iverdomide when compared to the polypeptide defined according to SEQ ID NO: 2 or SEQ ID NO: 3. Preferably, the relative affinities of the polypeptide defined according to the invention herein and the polypeptides according to SEQ ID NOs: 2 and 3 are quantified by the same assays. The binding assay used to quantify said the binding of said polypeptides to said compound of Formula (A) or Formula (I) may be any suitable protein-compound binding assays known in the art, wherein such assays may include computational in silico assays. The polypeptide may be attached to a target protein. The target protein may be any protein of interest. The target protein may particularly be a protein that is expressed in a cell. The polypeptide may be attached to the target protein by any suitable means provided that the polypeptide does not, by virtue of said attachment alone, affect structure and / or function of the target protein. Preferably the polypeptide is attached to the target protein by genetic fusion and / or via a linker. The polypeptide and target protein may be genetically fused. The polypeptide and target protein are genetically fused if both the polypeptide and target proteins are expressed in-frame from a single polynucleotide sequence. Suitable linkers for attaching two proteins are well known in the art. The linker preferably covalently attaches the polypeptide and the target protein. The linker may directly attach the N-terminus of the polypeptide to the C-terminus of the target protein. The linker preferably directly attaches the C-terminus of the polypeptide to the N-terminus of the target protein. Any suitable linker may be used. A linker may preferably be attached to the polypeptide and / or the target protein by genetic fusion. In some embodiments the linker and polypeptide are expressed as a single construct. In some embodiments the linker and polypeptide are expressed as a construct and the linker is then attached to the target polypeptide. In some embodiments the linker and target protein are expressed as a single construct. In some embodiments the linker and target protein are expressed as a construct and the linker is then attached to the polypeptide. In some embodiments the polypeptide, linker and target protein are expressed as a genetic construct. Practitioners are referred to methods disclosed in Sambrook et al., Molecular Cloning: A Laboratory Manual, 4th ed., Cold Spring Harbor Press, Plainsview, New York (2012). The linker may be flexible or rigid. Preferred flexible peptide linkers are stretches of 2 to 40, such as 2 to 20, such as 4, 6, 8, 10 or 16, serine and / or glycine amino acids. More preferred flexible linkers include (SG)1, (SG)2, (SG)3, (SG)4, (SG)5 and (SG)8 wherein S is serine and G is glycine. A yet more preferred flexible linker is a poly-Glycine-Serine linker such as GGGGSGGGGS. Preferred rigid linkers are stretches of 2 to 30, such as 4, 6, 8, 16 or 24, proline amino acids. More preferred rigid linkers include (P)12 wherein P is proline. A more preferred rigid linker is an amino acid sequence AEAAAKEAAAKEAAAKA. Another suitable rigid linker is an amino acid sequence. The linker may be a chemical crosslinker. Examples of chemical crosslinkers include 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate, 2,5-dioxopyrrolidin-1-yl 4- (pyridin-2-yldisulfanyl)butanoate and 2,5-dioxopyrrolidin-1-yl 8-(pyridin-2- yldisulfanyl)octananoate. The most preferred crosslinker is succinimidyl 3-(2- pyridyldithio)propionate (SPDP). Typically, the molecule is covalently attached to the bifunctional crosslinker before the molecule / crosslinker complex is covalently attached to the mutant monomer but it is also possible to covalently attach the bifunctional crosslinker to the monomer before the bifunctional crosslinker / monomer complex is attached to the molecule. The linker is preferably resistant to dithiothreitol (DTT). Suitable linkers include, but are not limited to, iodoacetamide-based and Maleimide-based linkers. The linker may be or comprise a polypeptide-based linker and may comprise one or more terminal natural or non-natural amino acids having a reactive side chain capable of binding to a reactive functional group on the polypeptide and / or the target protein. The or each terminal group may independently for example be a cysteine or a lysine residue. The attachment between the linker and polypeptide / target protein is not limited and any suitable attachment chemistry can be used. Many suitable reactive groups and their chemical targets are known in the art. Some exemplary reactive groups and their corresponding targets include aryl azides which may react with amine, carbodiimides which may react with amines and carboxyl groups, hydrazides which may react with carbohydrates, hydroxmethyl phosphines which may react with amines, imidoesters which may react with amines, isocyanates which may react with hydroxyl groups, carbonyls which may react with hydrazines, maleimides which may react with sulfhydryl groups, NHS-esters which may react with amines, PFP-esters which may react with amines, psoralens which may react with thymine, pyridyl disulfides which may react with sulfhydryl groups, vinyl sulfones which may react with sulfhydryl amines and hydroxyl groups, vinylsulfonamides, and the like. Other suitable chemistry for conjugating the polypeptide to the polynucleotide includes click chemistry. Many suitable click chemistry reagents are known in the art. Suitable examples of click chemistry include, but are not limited to, the following: (a) copper(I)-catalyzed azide-alkyne cycloadditions (azide alkyne Huisgen cycloadditions); (b) strain-promoted azide-alkyne cycloadditions; including alkene and azide [3+2] cycloadditions; alkene and tetrazine inverse-demand Diels-Alder reactions; and alkene and tetrazole photoclick reactions; (c) copper-free variant of the 1,3 dipolar cycloaddition reaction, where an azide reacts with an alkyne under strain, for example in a cyclooctane ring such as in bicycle[6.1.0]nonyne (BCN); (d) the reaction of an oxygen nucleophile on one linker with an epoxide or aziridine reactive moiety on the other; and (e) the Staudinger ligation, where the alkyne moiety can be replaced by an aryl phosphine, resulting in a specific reaction with the azide to give an amide bond. The linker may comprise a naturally occurring reactive functional group which can be used to facilitate conjugation to the polypeptide / target protein. For example, a cysteine residue can be used to form a disulphide bond to a cysteine residue on the polypeptide / target protein. A cysteine residue can be used to react with a mameimide group. For instance, a polypeptide / target protein as described herein can conjugated to a linker having a C-terminal cysteine residue using MBS (m-maleimidobenzoyl-N-hydroxysuccinimide ester). MBS is an amine-to-sulfhydryl crosslinker and thus can attach the cysteine residue of the construct to a lysine residue of the polypeptide / target protein. Other cysteine / lysine reactive groups can be used. As discussed above, the system provided herein comprises a compound of Formula (A): [Formula A] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - X3is CHRDor C=O; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O- C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, and C5-10 carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2 and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl. In some embodiments, the system provided herein comprises a compound of Formula (A) as described above, wherein: - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; and - each R20, which may be the same or different is independently H or methyl. Typically, the system provided herein comprises a compound of Formula (I): [Formula I] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O- C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2 and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl. In some embodiments, the system provided herein comprises a compound of Formula (I) as described above, wherein: - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or methyl. Typically, X1is C-R and X2is C-R. Typically, when X1is C-R and X2is C-R, each R is different. In some embodiments, X1is CR1where R1is as defined herein. In some embodiments, X2is CR2where R2is as defined herein.Typically, RAis H or C1-3alkyl, more typically H or C1-2alkyl , more typically H or C1alkyl, most typically H. When RAis an alkyl group, the alkyl group is typically unsubstituted or is substituted with 1 or 2 substituents independently selected from OR20, N(R20)2and halogen, more often by OH, NH2or halogen. More often, when RAis an alkyl group, the alkyl group is unsubstituted or is substituted with 1 OH or NH2group. Typically, RBis H or C1-3alkyl, more typically H or C1-2alkyl , more typically H or C1alkyl, most typically H. When RBis an alkyl group, the alkyl group is typically unsubstituted or is substituted with 1 or 2 substituents independently selected from OR20, N(R20)2and halogen, more often by OH, NH2or halogen. More often, when RBis an alkyl group, the alkyl group is unsubstituted or is substituted with 1 OH or NH2group. Typically, RCis H or C1-3alkyl, more typically H or C1-2alkyl , more typically H or C1alkyl, most typically H. When RCis an alkyl group, the alkyl group is typically unsubstituted or is substituted with 1 or 2 substituents independently selected from OR20, N(R20)2and halogen, more often by OH, NH2or halogen. More often, when RCis an alkyl group, the alkyl group is unsubstituted or is substituted with 1 OH or NH2group. Typically, RDis H or C1-3alkyl, more typically H or C1-2alkyl , more typically H or C1alkyl, most typically H. When RDis an alkyl group, the alkyl group is typically unsubstituted or is substituted with 1 or 2 substituents independently selected from OR20, N(R20)2and halogen, more often by OH, NH2or halogen. More often, when RDis an alkyl group, the alkyl group is unsubstituted or is substituted with 1 OH or NH2group. Thus, typically, X3is CH2or C=O. For instance, X3may be CH2. X3may be C=O. Any of the compounds of Formula (A), (I), (Ia) or (Ib), or (Ic) or (Id) as described herein in more detail may be comprised in the system provided herein. In some embodiments the compound of Formula (I) may be a compound of formula (Ia): wherein - R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered (e.g. C5-10) heteroaryl, 5- to 10- membered (e.g. C5-10) heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or methyl; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl. In some embodiments, the system provided herein comprises a compound of Formula (Ia) as described above, wherein: - R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, C5-10heteroaryl, C5-10 heterocyclyl, C5-10 carbocyclyl, OR20, N(R20)2 and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, C5-10heteroaryl, C5-10heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or methyl; and - each R20, which may be the same or different, is independently H or methyl. Typically, R1may be selected from hydrogen, N(R10)2, OR10, halogen, C1-4alkyl, C2-4alkynyl, O-C1-4alkyl, O-C2-4alkynyl, NR10-C1-4alkyl, NR10-C2-4alkynyl, C6aryl, and 5- to 6- membered (e.g. C5-6) heterocyclyl, and 5- to 6- membered (e.g. C5-6) heteroaryl. More typically, R1is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl. Still more typically, R1is selected from H, NH2, OH, OMe, halogen, methyl, NH-C1-3alkyl, and unsubstituted NH-C3alkynyl. Typically, when R1is or comprises an alkyl or alkynyl group, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl, and halogen. More typically, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl or with 1-3 halogen substituents. Still more typically, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl or with 1-3 halogen substituents. When R1comprises an aryl, heteroaryl, heterocyclyl or carbocyclyl group, each said group is typically independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group. Often said group is unsubstituted. Often said group is substituted by methyl. Typically, R2may be selected from hydrogen, N(R10)2, OR10, halogen, C1-4alkyl, C2-4alkynyl, O-C1-4alkyl, O-C2-4alkynyl, NR10-C1-4alkyl, NR10-C2-4alkynyl, C6aryl, and 5- to 6- membered (e.g. C5-6) heterocyclyl, and 5- to 6- membered (e.g. C5-6) heteroaryl. More typically, R2is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl. Still more typically, R2is selected from H, N(R10)2, OH, OMe, halogen, unsubstituted C1-4alkyl, CF3, phenyl, piperazinyl, and morpholinyl. Typically, when R2is or comprises an alkyl or alkynyl group, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl, and halogen. More typically, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl or with 1-3 halogen substituents. Still more typically, said alkyl or alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl or with 1-3 halogen substituents. When R2comprises an aryl, heteroaryl, heterocyclyl or carbocyclyl group, each said group is typically independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group. Often said group is unsubstituted. Often said group is substituted by methyl. Sometimes said group is substituted by C1-C4alkyl such as methyl, ethyl, propyl (e.g.iPr), butyl (e.g.tBu). Sometimes the group is substituted by 1, 2 or 3 C1-C4alkyl groups such as e.g. 1, 2 or 3 methyl groups. Typically: i) R1is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl; ii) R2is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6 aryl, 5- to 6- membered (e.g. C5- 6) heteroaryl or with 1-3 halogen substituents; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group. More typically: i) R1is selected from H, NH2, OH, OMe, halogen, methyl, NH-C1-3alkyl, and unsubstituted NH-C3alkynyl; wherein each C1-3alkyl group is independently unsubstituted or is substituted with 1 or 2 phenyl or pyridinyl groups; wherein said phenyl or pyridinyl groups are each independently unsubstituted or substituted by methyl; and ii) R2is selected from H, N(R10)2, OH, OMe, halogen, unsubstituted C1-4alkyl, CF3, phenyl, piperazinyl, and morpholinyl; wherein said phenyl, piperazinyl, and morpholinyl groups are independently unsubstituted or substituted by C1-6alkyl, preferably C1-4alkyl, more preferably methyl. Often, R10is H. Often, R10is methyl. Often, each R20is independently H or C1-6alkyl which is independently unsubstituted or is substituted with OH, NH2, or with 1, 2 or 3 halogen substituents. More often, each R20is independently H or unsubstituted C1-6alkyl. More often, each R20is independently H or unsubstituted C1-4alkyl. More often, each R20is independently H or unsubstituted C1-3alkyl. More often, each R20is independently H or unsubstituted C1-2alkyl. Preferably, R20is H or methyl. Often, R20is H. Often, R20is methyl. In another aspect, the system provided herein comprises a compound of Formula (Ic): [Formula Ic] wherein X1, X2, R, n, RA, RB, and RCare as defined above; for example, in some preferred aspects X1, X2, R, n, RA, RB, and RCare as defined for Formula (I). In another aspect, the system provided herein comprises a compound of Formula (Id): [Formula Id] wherein R1and R2are as defined above; for example, in some preferred aspects R1and R2are as defined for Formula (Ia). For example, in some embodiments the compound is a compound of Formula (Id), and i) R1is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl; ii) R2is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered (e.g. C5-6) heterocyclyl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered (e.g. C5-6) heteroaryl or with 1-3 halogen substituents; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group. In some preferred aspects, the compound is a compound of formula (I) or formula (Ic) (preferably formula (I)) and X1is CR1and X2is CR2; or the compound is a compound of formula (Ia) or (Id) (preferably formula (Ia)); and R1and R2are according to any of the following. More preferably the compound is a compound of formula (I) and X1is CR1and X2is CR2; or the compound is a compound of formula (Ia); and R1and R2are according to any of the following (preferably R1and R2are according to any of Compounds 1 to 36 in the following table):

[0002] The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 1; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is H and R2is H. A preferred example of such a compound is A32 (depicted in Figure 3). The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 2; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is H and R2is C1-4alkyl; more preferablytBu. A preferred example of such a compound is A63 (depicted in Figure 3). The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 3; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is H and R2is 6- membered (e.g. C6) heterocyclyl; more preferably N-Me-piperazine. A preferred example of such a compound is B08 (depicted in Figure 3). The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 4; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is NH-C1-3alkyl; more preferably –NH-CH(Ph)2; and R2is H. A preferred example of such a compound is A65. The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 5; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is H and R2is 6- membered (e.g. C6) heterocyclyl; more preferably morpholine. A preferred example of such a compound B03. The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 5; and preferably ii) a compound of Formula I wherein X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Ia); and wherein R1is H and R2is 6- membered (e.g. C6) heterocyclyl; more preferably piperazine which is substituted with 1, 2 or 3 unsubstituted C1-6alkyl groups. A preferred example of such a compound wherein R2is piperazine which is substituted with one C2 alkyl group is B22. A preferred example of such a compound wherein R2is piperazine which is substituted with one C3alkyl group is B25. A preferred example of such a compound wherein R2is piperazine which is substituted with one C4 alkyl group is B31. A preferred example of such a compound wherein R2is piperazine which is substituted with three C1alkyl (methyl) groups is B32. The system according to the invention may preferably comprise: i) a polypeptide that is at least 60 amino acids in length, wherein the polypeptide has at least 70% sequence identity to region of the same length within SEQ ID NO: 2, or more preferably at least 90% sequence identity, and preferably wherein the polypeptide forms a zinc finger structural motif, and wherein the polypeptide comprises the amino acids at positions 146, 147, 149, 150, 152, 153, 154, 155 and 167 corresponding to SEQ ID NO: 2 the amino acids set out in column 4 of Table 5; and preferably ii) a compound of Formula A wherein RAis H, RBis H, RCis H, X3is CHRD, RDis H, X1is CR1, X2is CR2; preferably wherein the compound is a compound of Formula (Id); and wherein R1is H and R2is 6-membered (e.g. C6) heterocyclyl; more preferably piperazine which is substituted with 1, 2 or 3 unsubstituted C1-6alkyl groups. A preferred example of such a compound wherein R2is piperazine which is substituted with one C1alkyl group is C01.

[0003] daerevitfe erdentoarCFgFoCdsenocol_oe23ultoc A512835260496169489 4 1 2 5 3 4 3 9 9 7 6 9 3 9 4 1 9 4 82237731700972940322583874250969201581036987901365620487164604884163794975 8 3 6 0 0 5 4 6 1 8076372479752406679490447173323061766115049299817171665845 4 2 0 8 6 4 3 8 1 8 6ag9 8 8 8 8 7 74 4 2 1 0 0 0 0 9 9 8 8e.3.3.7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6 63.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3 f1 htmGTAT A C C TTC GTT GTCTT G A GTC C T A G T C Cc AC C T A CTT G A G ATT G T CCno AC A AC TGC GCG T A G C GTAAAG A A A CAT GAG AAGACAACACAAAGAG GAiig nCAC C CACACACAC CAC CCCAC C C CAC C C C CACAC CFftis nii dt G G G G G G G G G G GTT G G GGG GGG GGG GGG G G GG geodopro ucoGtGG G GGGGGGGG G G G GGG GG G CGGGG GGGGGGGGGGGGGGGG GGGGGGGGGGG GGGG G GGGG G G GG GGGLsagncia ed dsT T T T T T T T TeGTG GATTTGCTG GATCTG G GT T C T T TAT TG GTGTGTGTGT TTGTGT TTG GT TTGTGTGT T TTGTG GTGTnnif nCTC TTeT T T T T T T T TC A C C A CGT T T TAT TT ATGTATA G C C CTT T GGT TGTATGT T T TG mgeeuGietdecd CG ATACACGTATAT GATG AT GGG G GAT G G GGAA GAstsqCeC C A A C C C C A CCC CCACC A A A A A A A ACCAC AEn nae n sCu oit di TC Ac GTTGTAGTCTGTCTGTCTGTCTGTGTGTCTGTCTGTTGCG C GTGTTGTGTG G A G G G G C C GGTGTGTGTGTGTGTGTGTGTG; tq u aGTGT T T T T T T T T T T T Ty uestio AAAGAGAGAGAGAGAGAGAGAAA A G G G A G A G A G G GtilmtalAs n C C C C C C C C C C C CACACACACACACACACACACACACACnaNb imCTCTCTCTCTC C C C C C GTC C C C C C C C C C C C CouDus a T T T T TTTTTTTTTTTTT CTTTTTTTTTTTTTTTTTTTTTTTTTTg doiv8 2 6 7 2 6 7 5 3 1 3 7 5 7 6 2 7 2 4 4 7 3 5 0 1hitr dDI0-11311300306301316307309396200311375691 9 5 9 1 9 5 8 8 6 0 82139292920392929292031392onino2hrg3cAaeeD.r1of4 5 6 7 8 90 1 2 3 4 5 6 7 8 9 0 1 2 3 4D1 1 1 1 1 1 1 1 1 1 2 2 2 2 252627282el st Ibnau QoE OTS N

[0004] 8694857049999 5 7 5 3 3 8 6 833 6 5 4 6 9 5 3 9 5 6 2 1 4 6 1 2 5 80 1 3 9 1 926412447620364275 0 5 6 1 5 0 2 5 8 2 5 4 9 1 4 8 9 02 1 1 4 6 1 2 8 1 2 7 2 0 631 28 078875058330586872871073973302896945 TTT G T T T G T TCT T T T T TGTT T T T T T T G G T T T G GTTTG A A CCCT T TCA G ACGTGC GTGCGT TGG GTCTATCTGAGT T T T T T T TAT GTT C A C GTTTGTACTT GT TAG T CTGGATGC CC GCAAC G AGCT C A G CT A CCAA GAG CC A ACACCT CCGACAATCA A C A A ACT AAAT GATA A ATC AACAT A A A AGAA GT AAAGC TAC C C T C C C T CGG T G G G TCG G G T GCTT CCT C C C T CAC T T C C C CTT CTT T C CGG T G T G G G TCG G TATTG GGG G T G T T GGGGG GGG GGGGG G G GGGG TGG G G GGGGG GG GGGGGG G GGC GGGGGGGGGGGG GGGGG GGGG G GGGGGGGGG GGGG GG GGGGGGGGTGT CGT T TGT T T C TGT TGTGTGT T T C TGC T T T TGTGT T T TGGTG GTGG G GCT T T T TG G G G GTG G G G G G G G GTGG GTG G G GTGG G G GTG TC CTT CTTTTTT TCTCT TTA CTTT TCTCT T T TTT T G TT T T T TTG CTC T ATCT TTC CTTTT T TTA T TT T TTC TTCT TTATA ATA G ATA ATA GTAT TATATATGTA ATA A GTATATA A ATG C CAT A A G A AGC C GAACACGT GGC C AAT A G A G A AAAG A G AAAGCTCCGTCC A A ACC GTG GC A C CCC G C CA C CATGTC CC C C A C CCC C C G C CC C A A A A A C C A C C AACCC C GCGCG G G C C G CTCCGTCTGTGTTGTGTTGTGTTGT TTG GTGTGTTG GT CTG GT TTG GTTGTGTTGTTGTGTGT T T T C TTG GTGTGTG GTGTGTGTTGAAGCAAAA G A G GTAG G GTAATAATAG G G G G G GTC G G GTT G A G GTA CCCCA T A AGCCGCCCCA A A AGC C C GG A ACA C GA AAC CA A A TCC C C GA A AGC C CACG A A A T A ACC C C C GCC CA A AGCCG CT T T T T T TCTCTCT TCTCT TCT TCTC CTC C ATC C C CTCT TC CT T C T T T C T T T C T T C T C TTTTT CTTTTTT CTTTTTTTT CTT C CTTTT7477612 2 0 6 3 0 4 4 2 0 5 3 1 5 1 3 5 0 1 5 4 2 0 1 6 0 3 0 0449 0 77019895870491 3 3 7 3 6 0 1 5 1 9 1 7 5 5 9 5 9 7 8 5 1 0936 3 3 7 7 3 2 2 3 6 2 6 6 7 72 3 6 3 3 2 7 3 21356230356037613921 7 1 0 8 8 1 9 9 0 7 9 7 7 0392031323334353637383930414243444546474849405152535455565758595061626

[0005] 4271888746559 3 1 3 4 9 7 1 1 8 3 147 7 6 7 5 6 7 2 7 5 6 4 2 4 7 21 3 3 7 0 163243524467082573 5 6 8 7 0 5 0 8 7 2 7 1 3 5 4 8 2 23 2 1 0 8 3 4 0 2 8 0 0 2 020164376 19 848344685842627535276071939825 TTT T G T T T TCT TT T T G T T T G T T G GCT T T T G GCAT T T T T T TTCTCTC CCG CT A TTC C TAAAGTGTCT T TTT T T T T T T TGACA G C T C T G C CCC T G C AAGTTGATTC GAG A TGTTGTGTGGT TAT A C AC ATTTT TCA CCT TTTAT TGC TA GGCGAA A AAAGACAA A A ACACAA CAA A A C ATAAA C A GCC AAA ACA TACGCGGCTT C C C C C C C C CCT C C C C T C C CCTC TT TTT C C CAC C TCTGGGGT GGG G G G GGG G G T G G G G TGG G G TTT T T T G G G G G TGTGGTGGAGGGGG G GGG G GGGGGGGGGG G G G G G GGG G G G G GGG GG G G TGGGG GGGT G G C G G GGGGGGGGGGG G GG GGG G GTGGGGTTGTGCGTG GGT T T T TGGTGG G GTG GCG GT TGT C TGT C C T C TGTGT TG GT T TTT TG GTGGTGG G G G GTGG G G G G G G G GTGG GTGTCTGTAT TTC CT TATCTGTCTGTTCT T T T T T T TTT C C C T CTA CT T T T T T T T T T T T TTCTC TTTTTTTTTTT C T G C T ATTCTGGAGATAAAGT T TGATACGAAGGGAT T TTGCGTAT TAATG ATAACAGATCG AAAAACACATCAT TTACAAGCT TGG GCAGAGGATGAGC A C C C A A A C C C CGC A A CGT TCTGTC C C G G GTC C C C C G A CATC A CCG C G CC C CCCCCTCCCCCC A C C A A CTC G C C A GTCTTGATGTGTGT T TTGTGTGT TTGTGTGT T C TTGTGTG GT T TTG G G GTTGT TTG GTGTGTGTGTGTTGT TTG GT TTG GTGTGTTAGAGAGAG A C G A G G C ATC GTATATAG GTAG G G G G A GTC GTGG G GCC CA A G A A A G G A C T A A A ACA A A ACACCAACGAA T A T A A ACTCCTTCTTACTTCCTTCCTTCC C C A C C ATTCTTCTTCTTCTTCTTCTTCG C C CTTCCTCTTC C GC C CTTTTTTC C C G ACTTTTTTTTTGCTGCTGC A C C C CCTC C C C C CCTTTTTTTTTTTGCTC552994515 0 2 7 3 0 2 2 9 5 2 1 1 7 9 7 1 8 7 3 6 3 2 8 2 7 2 7 0 89 9 9 7996013014999315 0 7 3 1 4 1 1 8 0 4 0 1 7 0 3 6 5 9 9 5 4 03 2 2 6 2 3 3 3 2 2 3331376041392037682139276767676760371033203877636465666768696071727374757677787970818283848586878889809192939495969

[0006] 62216 242 455 4 8 6 5 3 2 6 4 6 4 3 4 1 5 4 5 1 5 316788399575217486143225109737 9 3 7 6 1 36 9733 4861 60234398 1484 913 6 6 9 7 1 7 4 6 4 7 5 4 523103975004467 86 9850 2104 91339632 88 TT G T G G T T T T T T G T G T T T T G T T G T GTT T G T TGTCT T T T TCT T TTT T T TAT T T T T TCT T T TTT T T TGTGT T TATAAACTACC CGGCTGTC C TCG CCC A CTT C TCT T C TGAG AA ACTAAGCAGTGC CAATA G CCA ATAAT GACACAATAGGAACCAATCCTCACAGGATCATCTA A AACATACTTAAC ACAAAACGAACGAAAGC TTC T T C C C CGC C C CGT C TTC C C C TTC C C T C TTCGC C T C CGGCG TCTAGGGGGGG G GGTAGAG G GGGCG G G TAGT GG G TCG GGGGG GGTG GG GGGGGGGGGGGGGG G GGGGGGGGGGGGGG GG GG GGGGGGGGG GGG GGG GGG G GGGG GGGGGGGGGGGGGGGGGGGGT CGT T T T T T T T T T T T T TGT T T T CGTGTGT C T CGTGT T T T TTGTG GTGTGTG G GTG G G GTGTGTG G G GTG G G GTGT TG G GTG GGTC CTT T A GTTTA GT T TG CTT CT T TCTCTCT TCTT TTCTTT TTGT T T T T T T T TTTTTCT T T T TTTTT TGT T TT CTAT T T TTT TG ATGG AAA AA A A G A A G A A A G A A AAT GGC CG C CAC C A T A A ACTAAA A A G ACT C ACA AATATA A A AAACT A GCT GGAAA A AAC AAT T GAC CTCGTGACATCCTCCTCTAA A C CTATATCTCCTCATG CTGTCACAATA CCTC GCCC CTCTC CACGTGTGA ATGTATGC CCC CTTGATGTG GAG GT TG G G G G G G GTGG G GTATCT TGT T T TAT T TGT TG G GTGG G GTGG G G G G G GTGGGT T TGT T TGT T T T TGTGT T T T TCACAGCACAGGGTACGA A AAACACACAG CGACTGAGCACAG CGACTGATGCGATGAG TGACCGAAACA ACAGAGACTA AGA ACTC G C G G C C C C G G CCGG C CCC GTTTTCTTTC C C C C C C C C A C C C C C C C C CCTTTTTTTTTTTTTTTTTTTCTTTCTTTTTTTTTTTTTTTTTCTTTCTTTTTTTCTTTT8820750063695025107496 497044129935127 71253 56699601835 488314 01921387035646132303030 1390393768256039 139839 179037376828 378820339870 139798999 001020304050607080900111213141516171819 0 1 2 3 4 5 6 7 8 9 01 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1112121212121212121212131

[0007] 51317913117 2 659 5 8 9 9 6 4 3 8 4 561 6 6 8 2 181 1 1 8 4 7 1 2 19 6 9 8201647210118754192184117787 5 9 6 9 0 9 0 3 5 5 1 60 7 0 2 1 600 0 922 0 8 3 5 0 2 9 0 2 68 6065138839 10 5814208650978070 GTT T T GTT TGT TT T T GT CT T G T G TTTCGTT G G G TC TACT T TATAACCGG AGATCAAAACT AT T TAGTGG GCCCCAAA TG GTCTGCCTAT TT T T T TA AGTGC C G TAG G GGTGTATT TTTCAGTTATG C GC TA GGGT T T TG TTTATCCA C ATAG CC CTCCC CCTA A AAT ATC C C T CA A ATGC C CA A A TT TA AGCACCA A AAC A A AGC C C TCTTT C C T C T C CGCTT T CGC CCCC C AT CGTTT T CCTACAGGG G TGGGGGG G G TAT T GGG TTG T GGGG T TT GGGG GT TAG T GG GGGG CGG GGGGG GGGGGT TGGGGG AGG GGGTG G G G GGGG C GGTG GGGG G G G GGGG G GGGGGG G GGGG G G GGGG G G G GGGGGGGGGGT T T T TTGTTG G G GT T TTGTG GT T T C T T T T C T C T T T C TTG G G GTG G GTG G G G GTGTGTG GT T TTGTGTGCTGC TTG GT CGTG GTG TGTATCTTTTTCTGTTTTG CT TA TCTCTTCTAT TTTTATTTTTTTCT TTCTTTTTCTTTTC C TTT TGTCTCTTTTAT TTCTTTTCAG A A AAC TAT TG A C G A ACG G T GAC TA A A A AAC G T C GA AAA TA A A A A A ACA CCAAGAAAT GG G G AAGAC GAAA A G ATAA GAAG A CGCCAAACA A CCCGAAA CCCCGACCC G G GCC G GAG GCC GC CCCC T T T CGTGT TGTCT T TGT T T TGT TCT T T T T C T TAT T T T CCT CCG G G G G G G G G G G G G G G G G G G GTT T TG G G G G GTGTGTGTG G G G GA GTGTGATAT T T T T T T TCTCT TGTGT T T TC GT T TGTCTTT TCTA A A A A CA G ATACG G CT G CG CC ATC AGTGTGT AG A GT T CTT TAC C C C G AACAC G AACAC A T AAC A C A C G GAC G CACACAC G G A G ATG C C C A C C C C C C C T A A C G C C GTT T T TCTTCC TTC C C AC T T T TTC C C G G C G CCTTTTTTTTTTTTTTTTTTTTTT C C CTTT T T T T TCTTTTTTTCTTTTTTTTTT84604180824165184529693055999795475059905031756974581498634951275128 1 0 0 5 7 9 039373820377467692637673757 3 3 3 6 3 2 69393927687920392977697046632132333435363738393041424344454647484940515253545556 7 8 9 0 1 2 3 41 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1515151516161616161

[0008] 3758877672998 2 8 7 5 3 847 4 9 2 6 3 9 2 373 8 2 6 5 2 7 2 4 4 3 23 3 7 3 8 6024383380702485309835 5 9 5 7 4 2 1 5 0 8 7 3 6 0 84 5 3 1 3 2 2 4 7 9 2 5 3 857 6 21362321432 40 9738692209601875477979 GTT T T G T G T T T T TTG TGT TG GTG G GT C T T TG GTT TGCT TGTACTT TAGTCT T TCTCATAT TCA TTTAATTTATTCAT TCG T GT T T TTC A C G GCTGGT TTGCCCACCTACTCG CT TGA TCATAAACAATCAG G CCC AA C AA GGCCAT C ACGT TC GG A G G GAGCGATTG C C T CC A A A ACACACCA A C TT ACC C AC C AA ACA ACCCT A A AGC G GGTTAGGTC C C C C C T C C TGG GGG G G G T G GGTTAT TT T TAT TATTCTCG TTCGTT CTG GCGGGGTGTT C C CGT G G GGCGGGG G G GGGGGGGG G TGGGG G GAG G G GC T GGG G G GG GGG GGTG G G G G GGGG G GGGGG G G G GGGG GGC T T C CG GGGGGG G G G GGGGGGGG TG G GTGT C T T T T TGTGTGTG GTG G GT C T T TGG G GTGCTGC TTG GTGTTGTTGT T T TTG G G GT TTGTGT C T T TTGTG G G GATCTC A C CTT GTCTTT T TCTT C T CTC A T GT T TC G G G TT TCT TTATGAT T T T T T T TTTTT T T TCA C A AGA ACA G A G ATA A G A ATCT T T T TTTCT T A T T TCT TCTTTAAAA A AAAAG A A A C G G AGA A A ACA T AAAGACTAG A G A T TCT AA A AT GA AA TCC ACG C AATCA A CCCCCCG G G C GA A CCA CCAGG G GCCAG GACCC CAGAAAG CA A ACGCGTGTGCGT TGGTGGTGT TGGTCT CGTGTGCGCGTGC TGCGGT CGC TGT TGT CGCGGTGTATT TG G G GT TG GT TGTG G G G G G GGTGTGT T TGT T T TAT TAT TGTCTATG GTATCTGT T T TGTCT T TT AG G GC AG CTGT ATTCT AG GT A C ACT T AAC A G AG G AT TG TTAG CACACAC A GAC A C G A A GAC G G A C A G C A C T GACACAC G GAC AAGTC C C T C G C C C C C C G C G G G C GCTTTTTTTTCTTTC A C CCTTTTTTTTTTTTTTTTTTTCTACTTTCTCTCCTTTCTCCTCTTCTTCTTATTTTCCTCTTCTTT587726964052702792923 13527336300476140653314512159 06704280239540491636039287635682712 529718156929367977677978773764 0699203929776927103566676869607172737475767778797081828384858687888980 1 2 3 4 5 6 7 81 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1919191919191919191

[0009] 5759206 935 6 3 8 1 8 56257 8 5 5 5 3 4 9 7 9 5 1 1 8 1 86318 6 6 67 6 780972914046373681265304 93942 7 7 6 6 5 8 1 9 8 1 68 4 8 4 4 794 4 8 7 7 9 42321 7 808 4 0310278830699700309 3128 368434 TTT T T TTT T T T TT G T TTT TTT T T G T T G T TTT T T T T T TAT C TAG C GG CTGAT TAA TT TCG CTATCGT TCT GCAT T TGG T CTTTTT T T TGTCG TTC TT T T TG CC C GATT TGA TTACTGACAACACACCAG CAAAGCAC G GGC G AC GTGCCT GGG T GCGGC A ACGG A GGC C C C CAGAC CAA A A A A ACCA A AGC A ACC A A ACA A A A A A A AGG G GGG GCTTGG GC CGTGG GCGGCGGC CGG G GC C C T CGG G G TGGC T CGGGTAGCGGGGC C C C C CGG G G GGG GC CGGGGGG GGG GGG GGGGG G GGTGGGGGGG GGGGGGGGG GGGGG G G G G G GG GGGGGGGG GGGT GGG G G G G GGGG G G G G G G G GGTG G G G G G G GGT T T T TTG G GTG GTTGCTG GT T TGGTTGTTGT T TTG G GT TGTGTGCGTGT T TTGTGTGTTGTGT T T T T T T TTG G G GTG GTGTGAT TTCATCTATTCTATCTGTT G CTTTC GT TTTTTC G T T A G GTTT TC ATT CTA CA G A G ATCT TCT T T T T T ACT T T T A T T T T A TAT T TGT T T TAT A A T GA A GAC AG T GA GAA GG G A A CAAAG G G AG A A A C AAC G CAACA AAAAGATGATCAGA A A A G A A GAT C ACA C GAAATCTCC A CGTCTGTCTGA CTGTCTGCTCTGTGA A CTGTGTCTGC CTCTCTGTCACGTGTGTGTGTGATGCTCTCATGCTCTGTGTCTTG G G GGTACT TCTGGTG G GGTTTCTG GGTCTG G G GGTAT T TG G G G G G G G G G G G G GGT T T T TCT T TCT T T T T TG G G G GAT T T T TACTCGTAGTTGTGTGTATGCAACCAATCATATG TGACCGACAAACCA GAACCATG G G A GAACACACACCAAAGCCACG GAACTGAC C C C C C C C C C C C C C C C C C A GGT T T T TCT T T TTC CC T TTC C C C C C C C C C CT T T TTTTTTT CTTTTTTTTTTTTTTT T T T T TCTTTTTTTTTTTTTTTTTTTTTT115321 41 064180502539680008450247231849061606457312060849 857022451 0030491 304939366937392737171049283738276926377929292827 0396383929 439990010203040506070809001112131415161718191021222324 5 6 7 8 9 0 1 21 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2222222222222323232

[0010] 866601093517 8 444501856 6 783 3 5 6 2 2 2 5 9 8 3 6 8 7 1 6 73053121571500765831 5 0 0 9 7 7 5 2319 5749617650 9958 8 0 9 9 4 874 6 8 6 0 3 4 2 7522143864290844228 8709 6816944721 80 GCTG TTT GTT T G T T G T T T T TTG TTG T TTT T T T T GGTAC AT TCAAGCCT GT TTG TCA GCCT T TAGA TCAGCCT T T T T TGTGTGTCGA TGC AG C CTACCCCG C A T GT TCA CA CTCG C ACCCAGT TCT T TACC TAT GACTT GC GGG CCT T TTTAACC GCATGTT TA A T AT CCA A T A AAT A A A A ATCG AC G T A ACT AGAAC CAA A A AATCT CTGC TGGGTCGC C T C C T C C C C C TTT T G TGG GGTCG G TTG G G G G T T TTCGTCGG GTGTCCGCGGC CGG GCGGC C TGGGG TGCGG GCG GG GGGGGG GGGGGGGG G GGG CGTGG G GGG GGGGGGG G GGGAG GT TGT CGGGG G GGGG GGGGGGGG G G G GGGGGTGT T T T T T T T T TGT C C C T TGT TGGCGGGGG G G G GGTGT TGGT T T T T CTGTGT T TG G GTG G GTGTG G G G G G G GT TGT TGTGTG GTGTGTG GATTTATGTCTCTGTTTTTAACTTCTTATCTCT T TTGTATCT T TTTTATCTTCTATATTTTGTCTTTTT CTCTTTT TGATT TTGTATGA G ACAAGAA C A A A A G G A G A A A A A AGG GGAAA A GAG G C A G AAC AGC A A CA CCGCTCA GAA T C A A T A ACAC AAA AG TAT G A GAT TCTCAGCGTGTGTCATGTCTCTCCTCCTGTCC CTCTCA C CTGTC CCCCTCTCTGCTCTGTGA CCGTCTGC A CTCTGTCTGCTCTCTTG G G GCTTTTTTATGATG G GGTTTGTGGTG G G G G GTGG G G GGTCT T T T T T TCT TATG G G GGT T T TG G G G G G G G GGT T T T T T T T TCACAATGACGAAGCAACTGAGTC G CGGTACTGGTC TATCTATGGTAACGGATGATGAACTAGTCACGATTGCA G G AATAACTAC GTTA C C ATC C C ATC C TTC C C C C CT TTTCTACTC C C C G C C C C C C CAC GCTTTTTT CTTTTTT CTTTT CTTTTTTT TCTTTCTTTTTCTTTTTTTTTTTTTTTTTC35176355957 7674938 252639137292737180611256123998255795443597827934977693828 57963037 169046713045222817666763687629297717393837103428346334353637383930414243444546474849405152535455565758 9 0 1 2 3 4 5 62 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2525262626262626262

[0011] 17 71 6836488 257 5 7 6 5 2 4 7 7 4 9 3 1 5 8 1 19945 9 6 4 7 2 1 8 95 9 7 71874862305868419498852625 3 0 7 3 9 4 6 9 8 7 1 5 18 364 3 1 0 8 780 4 1 4 8 9 3 1 4 0949994612052 8006 5270082681099797 GTTT TGCCGTGT CTC GT TT TTTTTTTTT TT T T TCTTT TC GT TG T TTTT TTT T TTTGTTTTTGTTT TT G TAT T TGG GAT TC AAT GTG AACC G GGTC CTAGGCC T C G A T A AT AG CCCAC TTAAACT TT C CC AGTA GCCATA C A A CAC GAAGA CCAGAT A ACCCCA AGAATC CACGA A A A A A A ATT AGA A A AGACCA AGT A ATAC ATCGGGGTCGTA TT G TGT CTGG C C C C CGA G G G G GCGGC C T CCT C C C C G T C C T C CGG GGTCG T GGGGG G C T G G T GGGC TGG TCTGGGTGGGGTGG GTGGGGC GGG GG GGGGGGGGGGGGGGGGGGGG TGGGGGGGGG G T CGGGGGGGGG G GGGGGGGGGGGGGG GGGGGGTTGTCTGCGT TTGTG GC TGTG GTGTGTGTGTGTGTTGT T C T C T T T T T T T T C T TGTG GTGTG G GTGTG G G G G G G GTGT CTG GTTGTCATGTTTTC GT TAA TT TTT CT TTTTTTTCTGTGTTTTGTCT TTCTTTGTTT T TTCTTTCTTTT T TTCTCTCTCTGTTT CTTTTAACAG ATCCG AA CTA ATA A A G A G G A G A A A G GCT GAT G C TAT CCCCC G TAA G C G T CA G A AAA T G TA A A G GTA ACTCT A T T T GAAACCCCGTCTCCTC GCTCA CCG CTGATATCTCCTCATG GC CTCTCCCCC ATC GTGC A CTCTATC CCCCTCC A A CTC GTGTCTGCCTTG G GTTTGTATG G GTGG G G G G GTGG G G GTGG G G GTGGGT T T T T T T TGTGTAT T T T TAT T T T T T TG GTGG G G G GGT T T T T T TATTAAGAGCTGCG CTACCCACG G GAA ACACAGAGAT G G AGGTACCACGATGCA A A A GAACGACAACA CGAAG CGA TG G GAA A A AGGAG C C G G C C CCT T CCGAAC C CAGTC C C C C C C C C C C C C T C C C C C CCTTTTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTCTTTCTTTTTTTTTTTCTTTTTCTTTTTTTCTT31 1045795774737230901 3 6 5 4397397 756532769557337 3210072828767 966 959467692766336820 53919595382834 0697692137303367 16912669292036 179768696071727374757677787970818283848586878889809192 3 4 5 6 7 8 9 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2929292929292929203

[0012] 3817 90 41657028852 6 3 3 5 6 4 4 4 5 6 7 9 7 6 3 3 8 8 2 6 7 5 3 2 35 7 0 7 4 1 6409505102806423045553 4 7 9 5 6 7 6 2 6 3 8 2 7 9 31 6 222 1 6 7 3 3 5 7 4 1 8 1 3 8 471800986758050022089356408335800 TT TT T TCG G TC GTTTT T T T TC TT T T TTTCG TTG T TCG T T T TGT C CAAATTCTTTGCTC C GCT TGACGTACT TGCGT T TTC C CCA GGTGT T TGG AACAATGT TGCTAT TCC TAC TTGACTAAACA TAAAAAA A GAT TTGGT C A CATCT TGT ACAACT C ACA A A AACAAC A A GGT A ATA A A A AAC C CAT ACT CAA AGC CCCC AGATGTT C C C T T TGT GGG G T TTTT CGTCG TTGT GCGGC C C T C CCGGT C C C C C CCT T CGGGG T GGGGT GGG G G G G T T G GT C CTTGT G G TGCGGGG CGG G G GCG G G GG GG GTGGGGGGGG G C CGGGGGGGG GGGGG GGGG G G G GGGG G G GGGGGG GGG G G GGGGGGGGGGG G GG GTGT TTG GT T T CTT TG G G GCCTAT TTTGT T T TCTGCTGTTG GTCT TGT T T T T TGCT T T T T T T C T TATGGTG G G GATCT T TGGTG GCT TG GGTTTGTTGTG G G G GT TGCT T TTT TG GTGGTGCGCTAT TTTT T AAT T T T T TCT A T T TCTCT A TTT T TGT TTTTT TGT T T TA AAAA A C A AAC AAT T TACAACCACTGCCA C G G A A A C GTA G A G G G G A A G G A ATATAAT GACATCCAA C G TAC A G C C C A A CCT G A CCT TGCCGCCCCC C C C GCC G A C AC CCC C C CCAAC CCC ACC A CC CC CT T T T T T T T T T C T T T TCT TCTGTCTCT T TCT TCTGTCTGT C TC CGTG G G G GATCTATGT TGGTGGTGGTG G G G GAT TTT T TG G G G G G G G G G G GCGG G G G GTGTGGT T TCT T T T T T T T T T TGT T TATAT TCACCACAAACCATGAGAGAGGACTA GAACACAG CGACTGTA A G CAACACCTTGGTG AGACCGATCGCCATTTCATCGC CAATTTTTTC C C C G G G G C G C C G T T GACG ATTCTTTTTTTCTCTCTC C C C C C C C C C C C C C C GCTTTCTTTTTTTTTTTCTTTTTCTTTTTTTTTTTTTCTCTTTTTCTTTTTT16179788199962127302415735 69013615943554733841356535967573166 20656 7 6 0 7 765656569266920 53903046 063 2 6 4 4 3 3 4 3 7 6 4 3 6 9 53 6 3 3 30 9 7 0 0 0 8 0 8 6 6 0 7 7 8156102030405060708090011121314151617181910212223242526 7 8 9 0 1 2 3 43 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3232323233333333333

[0013] 265598255342918 953 3 5 7 4 2 3 2 7 8 7 3 8 2 3 6 9 5 4 5 8 2 7 3 85 4 9 1 7 2 59508622324189723808 6 0 0 9 4 7 6 9 1 3 7 5 6 5 1 34 6 6 7 9 5 0 7 9 257 2 2 1 0 7 33751069774815013328383637438382415 GTGTT T T T T T T TTT G T T GT TT T G T T T T G T T GTTGTAA GT T T T TAAT TCTACCA GGC TTGCTCT T T TGC G A CTCC CAATAATCTGGT TTCT TTG CT T TACAAATTCAT TAG C GTGTTACA C ATGAGGA GCTTCA A A A AC TAAA TGA ATC CC AAA AACCCG AAAC G A A C AGCGC TCAGT C AAT ACACA ACCTT A A A A T A A AAA ATTTT GC C C C C C CGG G G G G G GCGG GC T A CGG T C GTGTAGGGC C T T CGG G TCTCGC C C TGG GGGGTCGGCGGCCT C CGG TTGGGGCGG GGTG GGGGGG G G GGGGG GGGGGGGGG GGG GGAGGAGGGGGGGGGGG GG G GGG G G G GGG GGG GT T TGGGGGG G GGGG G G G GGGG G GTG GT T T T TAT TG G G G GT TGGT TTG GT T C TTG G G GCTGTGTTGT T C T TTG G G GTGT T T CTG G GTGTTGT T T T TTGTG GTGTGTTCATGTTTT T T T TTGTATTTCTTTGTTTTATTTTTTTTTTGTATGTGT T TTGTCTTTTTAT TAGTATCTCTATCTTATATGTTTCA G GCCCCG TG G A A A G G AAT C T A T A TCGG A A G A GATCG G C ACAGAAG A A AAT T AAGCAAG A AAT C CAAAG G A A G AAG G A CCA AACCAGCGTACTCC CTCTCA A ATG ATGTCTGTCA CTGCCATATCCGTGC ATCTATGTGTGC ATC ATGTGACGA CTGTCTCCTCTGTTG G GTG G GTGG G GTG GTG G G G G G G G G G GTGG G GTG G G GTG GCTTTC AT T TCT T TGTGT TAT TAT T T T TCTCT T T TAT T TCTCTT G C GGTAT ATTCTCT AGT AC ATGTGTC AC TG T G GTA C CT G AGG T A A G A G A A A G G GTAG AC G G GTACAA GACCAACAC ACAGT G CAG G C C C C C C C C C C C TAC C G GG CT T TT CC T TTC C C CC T T T TTG C C C C C C C C CC CTTTTTTTTTTTTTTTTTTTTTTT T T T T TCTTTTTTTTTTTCTTTTTTTCTTTT8807880291700 47 542118 710 104276519158431234193763320198421 84353 44464673230491 671817 4199 4397795037693939173979792830382777 433047 16792536373839304142434445464748494051525354555657585950 1 2 3 4 5 6 7 83 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3636363636363636363

[0014] 585059 46 813215137 8 5 1 8 5 8 8 9 9 6 5 8 8 8 1 2 5 8 3 7 2 6 7 1 49 4 6 9 9 5 04267026781583198130 9 8 4 4 8 0 8 9 7 4 7 5 8 1 7 04 1 4 095 1 9 6 0 9 1 7 8 4 3 9 71876505013239614868588651742543468 TT TTC T C TT T G T T G G T TTTTT TCTT T T G T GTT T TTGTGGGTC GACG TGT TCATT TAG C G GT T T T TAA GTA C ATCG ATATT TAC TCGT T TGAT TT T TGC G C TTGT T TGCATT A TTCTTA A ATTAA AGTGCCAA GCAA A ATT G CCC TGCA GC CCAC CGGTGACA ATC AC TACA AACAAAGTAC A A ACA A A A A A TAC A CA CAA ATCGCGGC TG CTGC C T CCT CGGG TAGTGG G T GGT GT T CGTTT GGGC GC C C CGG G G GC C GTT T CGG GGC T TCGTTT C C C TGTGT G GGG TGGGTGGGG GGGGG GGGGGG GGGGGGGGGG G GTG G GGGGTGG GGG GGG GGG GGGGGGGGAGGAGG G GGG GGC GGGGG GG AGGGGGGTTGT T TCTG GTGT C TGGTTGTGTGTGC T C C TTG GTGTG GC TGTG GT T T T T T C T TTG G G GTG GTG G GTTGT CGT T T TTGTG G GTG GTCTATCTATGT TC GTT ATT TTTTATATTC GTTTTTTGTTCTGTTCT TTTTCTGTACTCT TTTTA CTTATCT TTCTT CTTTTTTTAGCCA ACAA CGCGA CAC GA G A GTA G AAG C T G C TAAA G A G A A A C A G A A AAACCAT G A C A A G G A A GG A ATA A A AAACAAT C AAG GCTAAGTGTCCGCTCCGA CTGTCCTCA CCG CTATGTCTACTCA A CTGTGTCCTCCTCC A CTCTGTCCCC GCCTGCTCCCCTGATG CTTG G GGTCGTTTG G G G G GTGG G GATGT T T T TCT T T TGATG G G G G G G G G GTGG GTGT TCT T T T T T T TTT TTTG G G G G GGT T TTT T TCAACCCACATT G TGACACTAGACATTTTATGTACACTGAACAAGTCATA GAACCG C TAACGTCAATGCAGTAG AGTCTTCACCT GTTC C ATTTTTTC TCTTTC C C G C GCTTTTTTTTTTTC G ACTTTTTCCTCTTCTTCTTCTTCTTCTTCTTCTTCTTTTTACTCCTATTGGTTCACTCATTCTTGTTC784758646149986118153396505345725828815460839 210438643 26965 2771418303637693569293138671560387660316717103730 3347316766 579776 961637146960717273747576777879708182838485868788898091929394 5 6 7 8 9 0 1 23 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3939393939393040404

[0015] 303214406897584 9 9 8 1 7 3 3 5 1 6 4 6 7 1 7 5 7 368 9 2 7 4 4 6 19 1 5 8 7 3 04125068115930344115 0 6 9 5 2 9 6 4 2 7 1 7 5 6 8 69 9 7 0 0 3 5 6 1 2 3 9 2 0 5 929595933376090332762 05 82368834955272 TT CT T GTT TTT T T T T T T T G T TT T TT G T T G T T G GC G GT T T TAT TC TAT T TTG C A ACG GT AC CCGT TGT T TAGAA A GACTGCT T TG A TT TCG C AATCAT TT TAG TT T T TAAT TAC A C A TAC T A G AGCA ACT A A GCCCA C CACCT GCAAT TGT T GG GAAAC AAC ACA AACAGAC CAA A A A A A AAT A A A T A AAACA ACC ACAGC AG CCGTTT C CCTGC G CGC C C C C T C C C TTC CTTGCGTGCCT G GCT TGT T G G TGG CGG GGG C GGGG G T G GGGGGG G TGGGTT GG T C A TTTAGG GG G ATG GG G G GG AG GGGG GGG GGGGGGGGGG G GGGGGGGGGGGGGG G AGG GGG G GGGGGGGGGA C TGG GT GG G G GGGGGG G GGT CGTGT C TTG G G G G GCT T T TGC TGGT T T T T C T T T CTG GTGTG G G G GTGTGT T TTG G G G GTT TGGC T T T T C T TTGTGTG G G G GTGTTTGTCT T TTC TTTTGT TCTATATTGTTTCTTCTTTT TTTTCTCTCTAT TTTTCTTTTGT TC GTCTGTTCT T TTATCTTTATCTCACCATAATACATGTCC C CAA A AAC C AG G G A A A A G G A A A A GTAA A TCG T C G A AAGAG C TCAA G AAT G CG A A A A A ACACTCC T C TCTCTCGTCC CTCTCTCTGC CTCTCTGC ATC GTCC A CTCTGTCA ATG G GTGC CCC CTCTGC ATCTGTCCCTCCTCCTCCCCCCTCCTGGTGTGTGTGTG G G GTGG GCT A ATAT T TAT T TG G GTGTGG GTGG G G G G GGT T TCT T T TCT T TCTAT T TGGTG G G G G GGTGT T T TATGAACTTCGTCATATA GAGCCTA ACGTCACAAA CGTATGCT C GGTATATACC GATATGGAACGTCGCAACAGACGATAGAGATGTCTTTCTC C GCTTTTTC CCT C C C C C C A C C C CCTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTCTTCTTCCTCTTCTTGTTCGCTCTTAGTTTCTTCTTCTTGCTC6368309174730022503 85161 836256784492131573265 8939181 9 358451302683867681816623533 867917 4398183467171529781047 26804737 569094616367676304050607080900111213141516171819102122232425262728 9 0 1 2 3 4 5 64 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4242434343434343434

[0016] 67372453705 6 5 9 5 580 6 1 4 1 229 8 3 2 2 1 7 7 2 2 4 5 7 849 2 34 0 9 8 739505686467342046130807 2 9 6 6 9 8 2 8 6 7 9 5 5 16 1 7 5 7 4 1 5 0 5 9 329 9 1 9 6 81 03475725794450029798344483 41 5690 GTG G G TTG T T T TCT TTCT TT T TT TGCT T T GTT GTTATTGTTTA CT TTT GG CT T TGAT CT T TAC A GAT GCTC A GATCTTT TGC GTAGTGAGTCG GT T T TATA TCTGTTGAG A CC CGAACTTC GTCATTCAATCC GGTATACAC ACACAAG AACAA G ACA AT GCAG TAAG A A G G ATA A A A AAAGT C C C CCT C CGCT CCT C C C C C CTGAAGG CTC C CGT TAT TT GACATCC ATCA C AGCGT CAGCGTGCT TCGGT GGG G G T GGT GGT G G GGG GGG AT A G G TG GTGGGGGGCCGGGGGGG GAG GGGGG GGGGGG C GGG G GCGGGGGGGTGGGGGGGG GGGGGGGGGGA AGGG G GGG G G G GGTGT CGT T T T T TGT T T T T T C TGT T T T TGC GGGCGGCGGTGTG GCTG G G GGT T TGTTTTGTG GTG GTG G G G G GTG GTG G G GTG GT TG G G G GTGTGT TGTTCTATTTTTTCTGTTATTTTTTTCT T TTT CTTCTCT TATATTCTTGTTA CTTGTAGTCTCT TCT T T TG C C CTATC CTCT T T T TGAAAAA AGA G A A A G A A G A A A A GTA A C G AGAAA ATA G A G A A AGCAGCGAC G TCGATCT C T T GAA G C A T G A GA AT A C T C AAAAAA AACTCAGTGTGCCCATG CCGTCATAC CTCTCCCCTGCTCA CCG CC C A CCCTC GTCCTCTGTGC C C C CCCTCCC CTCCGTGTGCGTCTTGTG G GTGG G GTG G G G G GTGG GTGG G G G GTTG G G G G G G G G GG GT TTTTT TCTGT T T T T T T TCT T T T T TGAT T T T TTTAT T TGTA ACT G ACT AGT AA C C ACGTTAC CTT C A CT A ACTA C AT AG AAAC G T T G A G G GACGTGT A G CTAGAGCAGTAC G G G GA CACAAA ACGG G G G C C A C C C C T G CCGG ACG AT T TC C C A C C C C C C C T C C C C C CCTT C CTTTTTTTTTTTTTTTCTTTTTTTTTCTTTTTTTTTTTTTCTCTTTTTTTCTTTTTCTTTT954826953 37 584191 615 48832615934041628 80936 0864882388210 02994 3237566767 671569 0390 334468393567176047 033030 84767763673836 268918 97733738393041424344454647484940515253545556575859506162 3 4 5 6 7 8 9 04 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4646464646464646474

[0017] 60696192739036405 5 5 8 9 6 4 4 3 7 7 7 7 3 7 4 7 4 8 8 2 7 9 2 8 70 9 2 0 8 6 5 006772172206416355 3 7 7 4 9 3 3 3 4 7 8 8 8 1 2 7 20 0 4 1 9 7 8 5 3 5 0 0 9 5 1 7654053380260983172290445808363540395 C GTT G T G G G T T G T G G T T T T G T GTT G G T T GTGT TTCAC TTTTTCGC ACT T T T T T TACACAGAT TGGA C TT T TGCCG CCGCATCCT TGCCT T T TACCGAC G G C ATCCTG AAG ACT T TGAA GGA TT T TTCTGGGAA TT T TC C TTGCCGT CTT A GTTCT A ACTACTT CA C AATCTCC A AGCA T T A A A GTC AAT A AAT A A A C A C A ACAT GC TT GG TCAGT T T C C T C TGT TTGT T G G T GGGTCGGC C G T C T C CCT T C C C TGG GGA T G TGG GGT TCG G G TC T C C CCG T GGGGGG GGG G GCG GGG G GGCGGG G CGGGGGGGG GGGGGGGGGGGC GGGGGGGG GGG GGGGCGG GGG GGG GGG GGGGG G G GGG GGGG G GGC TGG GT TT TG GT T C C T T C T CTGTTGTG G G G G GTGTTGT T T C C T C T T C CTGTG GTG G G G G GTG GT T T TTG G G GT T T T TGG GTTGTGTGTATTT CTTGTCTTCTTTT T TTTTCTATCTTTATGTTCTGT TTTTTT TTCTTTTATGTTCTATTATTCTTT ATT TC CTTTTT TTA AACGA ACAT AG A A A G A A A ACCAGAG G G T CCGAGA G A G A A A A G G A AAGAA A A C G A G T G T AA A A ATAC TAA AA A AAA GAAATAGAATTGAGTA CTCGTGCTCA C ATGTCTGTCTGTGTGA A CCGTGTCCTCCTCC ACCTGACAA CTG CTGATATGATG GCCC GTGTGCTCTTGCTG GTG G G G G G GTATGGT TCTTTTT T TG GCT TG G G G G G G G GTGG G G GTGGTGTCT T T T TCT T T T T TCT T T TG G GGT TCTG GGTATCGCTCAAGACGTGTTCCCAATAGGCTAAGCC C GAGTGTCGAA CCGTC G TGATACTGATCAG G TCACACATTCGCATCAGACAA C C G C C G G C C G ACC C A G G GG AT T T T TC G C C C T C C C C C C C C C CCTTTT CTT C C CTTTTTTTTTTTCTTTTTTTTTCTTTCTTTTTCTCTTTTTTTCTTTCTTTTTT55068291323823949522952065700 6 0625387825734194553503829124859 1 52361322569267467783617642679 5730383364604970371667703823497737 9779782172737475767778797081828384858687888980919293949596 7 8 9 0 1 2 3 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4949494940505050505

[0018] 7481835855239 154 853 6 2 87201032221 1 796 6 3 8 1 8 6 8 9 1 833328556144604800 9 8 75 7553748887996570 9309 1 7 12094 6 8 2 0 998 1 9 2 9 4 9 042592316 33 7605795611453981 72 TTG TTTT GCTG TTTTGTGTTTT T G GT C TTCT TT C C CT G T TTG TCCT T T TATG G GTC GT T TC G G GT TGT T TGTTT T TAAATTT C C CACACAT CCCGC GG T CGG CTACGGATAA TCGTTGTAA T CAGTT T TCTCTCT GA TTT CCAGGAT C G C G GAGTG T C A TAGGA CTA AACTAAA A T T AC A GAC T GAA AT TTTA A C AGAA TACT AGTT C TTT C C T TTC C C TTTG T C G CT C C CCT TTT C C T C CTT C T CCT GGTCT G G TC CG G GGTA G TTTTGT G G GGT T T G G TCG G T G TAGC GTGGCGGCGGTTGGG GTGG G GG G GG G GT CGTTGG GG GGTTGTGCGCG GGGGG G GG GG GG GGGGGGGC GGGGGGGG GG G A GG GGGG GGG GGGGGG GT T T TGT TGTGT T TGT T T C T T T T C TGT CGT T TGTG GTT TGTG G G GTG G GTGTGTG G GTG G G GTG G G G G GTG G G G GTGTTCATCTATTCTTTT TTCTTTCT TTT TC ATCTTT T TGTTATT CTTCT TTC TTCT TTCTCT T TTATATCTTT TCT T TTC CTT CTGTCACAAAA A A A A ACC AAATCT T ACGA A A AAT T T GA GTATAGA A ATA G A A A A G A AAC T T AACCC C GAA C A T G GATA ATA A GAC C T A ACTTCGTGTGCCA ACATATCCGA C CCATCTCTGCGATGC CTCCCTGTCC CCC CTGC CTCTCC CTC CATG GCCCC CTC CCTC CACGTTGGTG G G G G GATT TCCG TTAT T TG G G G G G G G G GTTCT T T T TAT T T TGTGTG G G G GTGGTGG GTGGTGG GAT T TAT TCT T T TAT T TAT T TTGCAACGGCTTACAAGTT G GGCATATGGTATG TGACTTACAAGGT GACAACACGTAGC A TTCTAATGCGATCGTAATGGTAAATA C G C C C G G A T C G C GGTTGCTTCTTTTTCTTTTTCTC C C G C A C C C C G C C C C C CCTTTTTTTTTCTTTTTCTTTCTTTTTTTTTCTCTTTTTCTTTTTCTTTCTT6306176342230261524359624103330136 7935840 7914844253080125603 53703 4 6 7 7652735697735204879 872 6 6 7963 3 7366 6 2 3 7 4 1 6 4 36 6 3 79 6 7 7 7 1 6 4 7 1 9 9 0 8 5 6692506070809001112131415161718191021222324252627282920 1 2 3 4 5 6 7 85 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5353535353535353535

[0019] 875698263529655 5 5 5 6 2 6 1 173 4 2 6 3 7 3 2 7 3 2 1 9 2 7 5 5 88 6 1 3 9 5 08905892344179102511 0 6 4 0 4 5 3 3 8 7 8 8 2 0 2 19 8 4 0 9 3 9 6 1 3 6 2 4 3 7 6 97 8327061773177781930182904992941706 TTTT TG T T T T T TTG T TTG T T T TTGTG T T T T GTGC CCTCT T T TTGGC GGGATG CT T TC GT T TTTTG CTA GAG AAAACTGT ACCC GC GT TAA TC GT T T TGGAGG CAACCC AAATGGTAAA TT T T TGCAGC T TTGT TCTGACACTC CT G GAGG TACG CAAA A A T A C A A A A AC ACGC ACAA T A A A G A A C ACC A A ACAA GC AC AC CGGCG GGT C G CGTCGGC GC C CGG G GGGT T C C CGT T GGG GTGTC G C G C C TAG A GGA G GGTGGT C CGT GCCT TG CTGG GGG T TA GTG GGTGGTGGGGGGGGGGGGGGGGGGGCGGCGGGGGGG GGGGGGCGGGGC GGGGGGGGGGGGGGGGGGG TGGGGGGGGG GCG GGTGGTGT CCTGTGT T T T T T TTGTG GTG G GTGT T TGTG G GT T TTG GTGT T T T T T TTG G GTG G GTGTTGT T T TTG G G GTTGC TGG GT CG TGTATTTCTTTTGT TTGTCTCTCTTCTTCTCTTC CTCTTCTTCTCT TTATTTATCTGTTTTTATTTTGTTTT TTTTCTGT TCGAGCAACACA CAA A G G A A AACAA A A A G AA A GTA A AATCA G T GAGA A A A ACG CCG C TG AAA AG A G A G A A A GTAG ACC A AAT A ACAAAATGGTCTGTGCTCA C C ACGTCTCTGTGTCACGA CTGTCTGTCACG CACGCTCTAATG GACG CCTCCTCTGATAATG CCGCTCTTGTTGTG G G G G G G GGT GTGT T T T T T TG G G G G GTGTCTTT T T TG G G G GTGGTGGGT T T T TGT TAT TG G G GTAT T TG G G GAT T TCTGTTCCAAGTG A T CAACACGTTCACCAGTAGAT CCGCGTCAATGGG G C ATTTACGTACACGTAGTACAGGATGT AGACT ACACTATC C G C C C C C C C GTTTTTTTTTTTTTTTTTTTTTTTCTCCTCTTCTTGTTCCTCTTCTTCTTCTTCTTCTTCCTGGTTCATTCGTTCCTTCTTTTTTGGCTCCTCTTC57 741 570 519843 01188 5 16906 56871514333 693 4386750629708 5604908 1803 987823 463917 13387568 573739386223 1633 56871877376045 32803675 3686693041424344454647484940515253545556575859506162636465 6 7 8 9 0 1 25 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 56565656565757575

[0020] 10 63585141 4 4 1 8 4 4 9 9 4 1 7 9 6984741 8 358 391 8 4 8 7 4 9 81 221944954949811547896156701845359416330579785 0 223 3 4 5 9 8 4 9 6099 529055 4574 04 6348 65 15260810858870 TTTTGT T CG GTT TTT T GCT TT CG T G G TTGTT TTTCTGCGTG GTT T TAT TGT TGGTGTAT TTGAA CACTG ATCAT CAT TCTATCTGTAT TAT TGGTGT TGTTGA AAGGGG AGTT AG GAGCAGAATCAC A AGTT CAC ACGT C CGTG AACCA G ACG AG CAC T GA AA A ATGTC CC AGAC GCCA AC C G AG GA T TCC A A ATCA ACAGCGGGGGGG CGT TTTTGTTGCGGGAGG CCGA GTTTT GTAC CTCG GGGGA TCTC TCT CCG TTT GGGTGTC C C T CGG GGG T G GCGGGGGTGGGGGG G GG TTGGG G GGGG GGG GGGGGT CGGG GTGGGCGGGGGGGGG GGGGGGGGGGGGGGGGGGGGGGGGGGGGG GGG GGTTGCTGTTG GTT C C TGG GTGTTGC TGGT T TTG G GC CGGT T TTG GTGC C T C C T TTG GTG GTG GTGC T T T T T TTGTG G G G G GTTGTTAATCTGT TATTATATGT TAT CTTTT TTTTTT TTTTA ATTTTCTATTCTCTTTTCTTTTATATATTTTTTTTTT TTATTTATATCG GAACGCAAA A A CAT A ACAG A GTAC C GA G A A A A G G A AAA A A T ACA G GAA CA ACA TA A ACG G GA A G A A G A GAACG G ACC C GAAA C G GCCCC C GC CCGCCC CCCCC AGCCCCCCCAG CA ACCCCGATGT T T T C T TCT T T CCT TCCCTGT TCC T C CGT CGTGT T CCT TGTTGGTGGTG G G GGT TCTCTG G G G G G GCGG G G GTGGAT T T TAT T T T TAT T T T TG GTCT TG G G G G G G G G G GGT T T TCTTT TGT T T TT G AGC G CG C AAG CCGTTC AC CTGTTC AAAG T GG ACT ACTC G CG A GAC A T AACGTAC GAA A T GAC G A A GCAGTCGTCAA G G TG A GCTC C C C A G C C CCT A G T AGGT C TTTTTTTTTCTCTC T C C C C C C C G C C C C C C C CCTTTTTTTTTTTTTCTCTTTTTTTTTTTCTTTTTCTTTTTCTTTTTTTCTTTTTT0604 73 0707098737 312 392835664842395003191895235 35645 434 014 485 19333 8927646769 7243 3683683667616619352065673566 163637 5659 1395 7649 423374757677787970818283848586878889809192939495969798 9 0 1 2 3 4 5 65 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5959506060606060606

[0021] 51789673177633587 4 9 7 4 4 2 1 1 4 2 2 4 2 2 3 3 5 4 3 4 9 4 3 4 29 2 8 3 7 4 0 225504075196853474 3 1 9 8 1 4 7 1 0 2 1 3 8 2 7 5 67 0 4 2 1 3 7 5 4 9 8 6 3 4 2 0477284055048094389331546542319149829 GTT G G T GCT T T T T T T T TCT T T G T T T T GCGTT T TTTATT T T TGTTC G CC TT G CATT CTCC GATTTTTGGTGACTTTTTGT T T T T TCA T T CAC C AT T T T T TGTTT T TAA C G GGCCCTC GGG T CTTAATT CC TAA T A GTT CCT A AGA ACTATCACAAC AAATA ATA ATCCG GA CA GGTGCACAAAGG A TAG T A TTC AC AG TAT GATC TCCCC CCC C C C C C C CT TTAGGT T T T T T C G C G T C C T TGTATCG TTTCGGG T G G G TCG G T G G C G C TTG G G G T T TGGC C CGG G GG G G GGGG G GGGCGGGGGGGG G AGG GGG G GGG G G G CGAG GG G GG G G G G G G G G G G GGGGGGGGGGGGGG GGGG G GGGGGGGG GGGG GTGT T C T C T T T T T TG GCG GC TG GTGT T T T T T T C T T T T T T C CTGTG G G GTGTGTG G GTG GTG G G G G G G G GTG G G G G G GTGT TGTGTGC A ATCT TA C C GTTTC GTAT TTTCT TTT T TT AT T T T T TC GT T TTAT T TGT T T T T T T TGTCT T TCTCTCT TT A ATCTCTTT T TCTC CTGG A A A A G A ATA ATATAT TA GTCAATG G GCA A A CG A A A A A A A A G A A ACA T ACA C T ACA A CCC TAA T G G T A G A TCC G AA A AAA C TCCGGTCCCCC ACCTG CA CTGTCTCA CCGTCCTCTCA CCG CTCCTC AC C CTCTC CCCCC C A CCCTC G CTCCCCACGTGC C CTCTC CTTG G GCG G G G GTG GTGT T TG GTCT TG G G G G G G G G G G GATG G G G G G G GCT T TGT TAT T TCT TCT T TAT T T T T TTT T T T T T T T T T TGGTACAT TGGTAAATCCGTGAGGCCAGTATGCGAC GCTATGGT GAGTAA C GGA GTA GCTAT T C GGATTTG TG CCT TG A C GAA C T TGTC G G C C G C C C C C C G C C A C CCT CCT G C C CCC GAT GGCACACGCCTTTCTTTTTCTTTTTTTCTTTTTTTCTTTTTCTTTTTTTTTTTCTTTTTTTTTCTCTTTTTTTTTT68448728927674665 277 1 3 248656363 1 142 03238 0214700549705 109167369256468297469 4397 06317325671047 364583 264364 66654013366667 278738104708090011121314151617181910212223242526272829203132 3 4 5 6 7 8 9 06 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6363636363636363646

[0022] 658959913823309 1 1 5 4 2 6 5 499676345536333688592 8 335 3 2 9 1 7 9 5 4 893997 5 6 9 6 5 7 7 88 641040166692 4534 1 7 6 7 6 0 7 9 1 6 5 2 004 7475430201234960972 99 990360763847 69 TT CAGTT T T T T T G T T TTT T TTG T T T T T T T T T T T T TATC CTACT GCT T T T T TGA A C C C GCC GTTGGTAAT TGCTTT TG TG CAGCAGT T TGT T T TCCG AGCCCCTT C T C T GGAAT G ACG A T T T TTA G C GT T T TC A ATTT T GAC G TAT TGTC TTAATATATAC TT A ATTGAA A A ATT A A G A A G AA GC AGAAC GAA ATATAA A A AAAGT CGT GCGGT C C C C CGTGCG GCG G G GGG G GGGGT C C G CGGTGCGGGG A GC G CTT T C C CTGG AGG GGGG CG T TGG AGCG G GT C C C C C C G C C CGG GT G G G G G G AAG GGGGAGG G GGG G GGGG GGGGGGTG G G GGGGGG G G G GGGG GGGGGGG G GGG GG GGGG GG GGGGGGGT TTG GTAT TGT T T T T T C T T T TTGTG G G GTGTGTGTG G GT C T C T TGT TG G GTG G G G GTG G GC T T T T T T T T T TTG G G G G G G GTG GTGTTTCTCTCT T TTG ATTTTTCTTTCT TTCTCTAT TTCTCT TTCTATTTTTTTCTGTTTT T TTG ATCT T TTC TTTTCTTCTTG AAAACCACCAGCAAATGG A A AGACGCT A G ACC C A ACA A G A A A A A A A G G G ATGA ATA A A A AACTG GAAAAA A AGA C CGCAC A A T AGCCCCCCCCAG G G A T T G C A G GGA C A CCC AAA A C A AG C CGA CCCTGT T T CCTCTGT T T TGTCT T T T C T T TG C GT CCT TG A CTGTGTCTTG GTT TG GGTATG G G G G G G G G G G G G G GTTT T T T TGTGG G G GTGTGGTGGTGG GGT T T T TCTCT TTTCTCT T T T T T T T T T T T T TAGA A AT CTT GT ACTCCATGG AGA G TTTT C GTC A T T TAC G T G CGGT G G GGT AGT G G A A AAC A GAG T A ATATACTACATACAT A T A CCTC C C G C C C C C G CCG CG A C A C ATTC C C C T C G C C C C C C C C C C C C CCTTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTCTTTTTTTTTTTTTTTTTTTT86 160 6 658 91 010 701 71476416202 202 178546850992530930553 175769519726 7385 6649 1139 538776391364 7363 7664677719171669173717 6367147710383142434445464748494051525354555657585950616263646566 7 8 9 0 1 2 3 46 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6666666667676767676

[0023] 152515252592428 3 739 7 1 9 9 7 3 7 7 6 648 8 7 2 7 7 8 2 6 5 6 14 4 7 5 8 0 0404377 71495495805473 0 8 4 2 9 7 8 7 5 5 0 3 1 8 17 0 5 3 1 7 1 3 7 4 639 0 8 8 2 16879143718 68 9018028699899084990015 TTG TAT T TTCTTTTTTTT T T TCG T T T GTT G TTT T T GT T CT GAC GCGTGT TCCT T T TATCC T C GCTTTCTGTGTATT GTAGT T T TGG C A C GCT TCGTGT G G G GTTGTTGGT TACTCCCGACCCC AAACCA G C GGCA A A A ATAACAGT AAG TCC CCAAAAAACC CA C CCACAAGAG GCCAAC A AC CTAACAACGCT ATAC T AA TGTTCGGCGCGCGCGCGC CGCGTTTTC CGC TTCGCGTTC C CTGTTGATTCCGTT G TTCGCG C G GGG CG GC GG GG T G GT C GTGTA GGGGGGGG GGGGGG GGGTGGG G GG GGGTGG GGG GG GCGA TG GGTG G G GGGG G GGGG G G GGGGGGGG G G GG GGGGGGG GGGGGGGG GGCTGT TCTG GT T T T T T T T C CTG G G GTG G G GTG GT T T C T T CGTGTG G G GT T T C C T C TTGTG G G G GTG G GTGTG GTGTGT TGGTTGTTATTATCTTTT TTCTGTCTTAT TTTTCTATTCTCT TTT TTCTTTCTGTTCTTCT TTC T AT TTA CTTTGTTTTATTATTT CTTTA GAAAG AGCT AA G G A A A A AAA C C GAA A A TA AAG AC GTGTA AACG G ATATA GTA A A G A G ATA A ACA A G T A TAT A AAG CCGAT C AAGATCCTCTGA C CTGTCTCTGCTCC ATCTGTACTCCCC CCCTCCTCTCCTCA A C CTGTG CTC GCTCCCC GATG CCGCTCCCC GTGCGTGCTG GACTCTG G G G G G G G G GGT T T T TCT T TGT TG G G GGT T T TG GTGGTGG GCGGTGG G GCGG GGT T T T T T T T TGT T TCT T TATGTCCGGAGG C GACTGTTAACAGT CAGTTAACGGTGC GGGTTTGGTGG G C C C GTGTTTTTGTTTTCTCAT AT GCC TAAGCTTC A GCTATTC C C C C C C C C C TCTTTTTTTTTTTTTTTTTTTTTCCTCCTCTTCTTGTTCCTCTTATTCTTCGTTCTTCGTTTCTATTTCTTCGTTCCTCATTTGCTCTTCTTC39437295943 67 026604 164 07997 286 861314739 625296041644716 48549 227446531343 462635 2347 418465 7640 2448634226 3741183664687436 965763 96787576777879708182838485868788898091929394959697989990 1 2 3 4 5 6 7 86 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6070707070707070707

[0024] 59581897 29 72938 8 1 3 5 7 6 6 8 4 8 5 363 5 9 1 8 4 7 9 8 1 7 1 8 86 3 0 6 4 7124718571013358533528 3 2 2 4 4 0 3 8 9 4 6 4 4 3 91 5 8 6 284 8 8 5 8 7 2 5 1 2 8 5668097 59 39764272362616595874170947 TTTAT TC TTTTTTTTTCTTT TGG TTTT T T GAT T T TGTTCTTG T TGT C C CT G G TT TCT T TG GTTGT T T TTTG C GTCGAGG T GAA CGGCAT A TC CG CTTCCGG GT TT TTGAG G CATA ACC A AACCC G C CTGTACGTAC TG TTTA TAC AT AGCACACGCTC AAA A AGC CA A A A GGC C C C GA AAC C CT A AAA ACGT C CAC C CC ATA C A ATTT CA CTAACAGT CCCAC AT C TCTC C TCTTC TCT C GG GTGGGG G G GGAGGTAGGG G GGTCG T GTG GGTCTTT G TGT G CG GTGGGG GG G GTG GG G GGGGGGGGG GGGGGGGGGG GGG GGGGGG C GGGGGGG GGG GG GCGC GGGTGGGCG GGGC GGG G GGG G G GGGG G GGT TTG GT TGTGTGTGCGTGT TTG GC T TGTG GT T T T T C TTG G G GTG GT T C TGT T T C T T TTG G GT TG GTGTG G G GTG G G GTTGCTGGTTA GT TGT TCTCTTAAGTCT TA GTT TCTCTTGT TTT TTGTAT TTG TTCTAT TC CTTT TT TTAAT T T TCT TCTTTTTA G GTT T TCTCA GAA GA G C G AAA C T A GA GAT AA ATACCCG A A G ATGA GAC T G A A T C A GA G A ATAC G AA ACACT AA A G A G G AAGATCG A GAGAAAATG GA A CGT TG ATCCTCTGCTCTGTCTACTCC A ATCTGTGCTCC CCCTCATGTGA ACATGTCTCCCC GTGCCA CTGTCTGTGCTCTTG GTGG G G G G G GGT TTT AT T TATGTGT T TGGTG G G G G G G G GGT T T T T T TTT TG G GGT T TGCGG G GGTTT T T TG G G G GAT TTT T TCGTT CCCGCTCTAACTC GGGCGTACTAAC AGGTTC GAGTTG TAGTCATAATACAATTATGGTAC G GATTGTTAACGCAAGGGC GTTC C C C C C C C C G C T G G A G TG T ATTTTTTTTTTTTTTTTTTTTC C C CCTTTTTTTTTTTCCTTTCCTTTCCTCTTTTCTACTCTTTTACTCTTTTTCTTCTTGTTT21802533325386629 78966 3 186 25141424069103105409935353183607239111942223228103044 374926 568648 11352868366719781938666561487567316147346900111213141516171819102122232425262728292031323334 5 6 7 8 9 0 1 27 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7373737373737474747

[0025] 855689162 5 3 277 3 4 6 41 8 3 55283448953761853 5 5 2 9 2 1 9 076 1 296 __IV00_I_ _V_ _V_ _ _I_V _I _I55 0I0 0I0 0I0V0 0 005 0__ 5 5 5PP _5 5_5 5 5_5__ 5_99_E_P P_P E_E_E P PEP44 9 9 9__ 4 49 949 9 9 9944 94D7M_4_4_ _4_4_4_ ___47T_47S V4747S47V47E S D DMN474747 74747_L_F_F_L_ _ _ _ _4_ _ _4_6 6 6 6F6F6F6L6F6L6F F L4 4 4 4 4 4 4 4 4 4646464GTG GTG G G GCTaC CTG GT T Taa a TaCaCTaCaCaCaaCaaG GTTGCTGCTCa Ca aaaaaaatt atattaaataatatatattt attaa att aatt atatca aac c t tata a a a tta atacacca accac c ccaca accaccacac cgc c a ac ccacaccgccgc cgccgc ccg gccgccgccc ctc c g gc ccgcgcct tcc ccctcctctctcctc ctccc ctc ctcctc76tcctctcc cccctcctctctcctc cttccc ctc ctcctcacaaca cta a ccaccacacac c taaaaacc cac caaaagtggtg aag g tagtagtgtgt t a t tatgggggatggg gaaaaaa g g ga a a gga a aaaaaa a aaaaga agaagaaaagcaga a a a ag g g atc c gagaga a aca a aggaagaagactactc c c c ct tct actcTa a tTctactacacac c cTaTaTtc ctcctcaaTa aGTTT TT C TTTT T G TCTTTCGATG GT TTT TGTGTT GTAT TAAAC ACCCGT A C TTCACCGCT GTATCA GT A A GCC ACA ACCCGTA TCT G TTAACACTTTG GTT GCGG TGGTGT G G TGGGGGCGG G GGG GC GGGGGGCG G GGGGGG GGT TGT TGG GGT T TGGTG G G GGT TGTGCTGAT T TGTGT T T TGT T TGTTC ATCTG C CTATCTT C C CATAG A ATGTG A GTATGTATACG G CACT T G AAGACCG A CCCTCAGCCCCCAG G CCCAGCCGT T TGTGGT T CGT C T T CTGCTGT TCTGTGTT TGATGCTGTTGTGTAG CGG TAC G CGTGACTCACATGGGATGGGAAGAGTAAA TTTTTTC C C A C A C C CCTTTTTTTTTTTTTTTTTC805 3 1 6 5 7 3 0 405 5536664770555 7 6 007 7 96 2 3 6 4 3936743564266344454647484940 1 2 3 4 57 7 7 7 7 7 7575757575757

[0026] daeferoCddetoarCFgsenocnol_onif36ltocn A45 366 611 87383579975 9 5 2 5 7 2 3 1 9 2 8 2 4 4 2 2 531856293654320722401621074142275014280 8r 8 552 928538644768702539472830122 8 8 5 6 8 5 3 6 691 71549574 3 4 5 5 4 5 7 6 6082715045153774845 88evi0 9t0a.9.43591 1618030006948279676260685852 7 5 6 3 11.93.93.93.93.93.93.8 8 8 8 8 8 8 8 8583838282828 8.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3 3ge fe 1FhtmuACC GTC ATACC GATT C C T TTATGTAGG C A G TTT A AnoiACAAAC AAC A ACAA G CGG C GAC C CCTAGTG G CTC A Ct gnA ACAAATAATAGAAC CACAC ACA A A A AC AACAi niC C C C CAC CGC C C C C CA AGC C CGC C C C CAC C CCifis dt G GGGGG GGGGG G GGGGGGG G GGGGGGGGGGGGG G GFg eodopro ugc oGLsa nc tGGGGGGGG GGGGGGGG GGGGG GGGG G G G G GG GGGGTG GT GGGTG G GTG G GT GGGGGGTG GTG G GGGG Gnia ed dsTGTGGTGTGT TGTGTGT T TGTGGTGTGTGT TGTGeecTCTGTGCT TGT TGTGT T TGT TGTGTGT TGT T T T TGT T TeTATGTA GATATT GGT TC T CGTATATCATC GGTGTT A TTTGT T TAGTCGTC C TATATGTA CTCTTATA mgie etdeecd ustn sqGne G AGAC AAAG G C GACCA GATAT A GAG G G G GAC G AsA AGA AGC AGA CC G CA AGA A AGCCAGAGA AGA AGAGE nTGaeu oit dic GT TGG GT TCT TGT T T TGT TATGTGT T T T TGT TAT T TTG G G G G GTG GTG G G G G GTGTGTG G G G G G;ytq u a TTTGT TTT TCTtueisti lmt oC C C CTAATCTTTCT TG A GTTT TGT TTTGnA T G T CCT C A G C G A C ATATA G G G CCA GCT C GalAsnaNb iCmCTTCTTCTTCGTCTTCGTCTTCGTCGTCG T G T T T G G T G T T T G TTCTCTCTCTCTCTCTCTCTCTCTCTCTC CouDus a T T T T T T T T T T T T T T T T T T T T T T TTTTTg doiv212784 2 825 48818061202 52523294103144743552 8 2hi Dtr dIn-5n1011 749011 1113431414 1414434343141144419406 5114oi3h org6caeA eD.r2o 6 7 8 9 0 1 2 3 4 5 6 7ef 5 5 5 5 6 6 6 6 6 6 6 686960717273747576777879708l stDI 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7bnau QoE OTS N

[0027] 5452177213409048673 9 8 3 5 3 6 1 3 1 9 5 2 4 6 9 1 5 6 9 5 97221 20 2 3 0 7 6 1 109510455577944369250126288119 6 7 2 6 4 6 7 05 6 9 4 4 3 9 7 9 961 4 7 7 7 9 5 6 7 4 8 7 18829680917447165 1384 72 8 9 4 6 6 8 1 9 7 7 3 3 4 8 3 7 7 8 3 363 7 9 8 5 0 1 32 0 4 0 9 5 6 2 3 80552 67 2 6 4 3 1 107765 2382995838221087170751995852968490385423128 8 19 TT T T TTTT TT TTT G T T G T T T T T T T T T TTG T TAT TATATGTAGT TGC A CTT C AT TC AT T T T T T T T TA C C G GTC G ATAAAATA C TCCGA CT TT GT TG CTC GG AT TGA CTGT TGT TGAC AA ACA TGAA C AGT A TAG TAG C T AAA C ACTGA G T C G T TGACC A C AACT CCA GCA ACA A ACAC CACA AC CA TTACA C A ACA A A AC ACA A A AC CC ACT AGCGGGGGCGGC CGGG G G GCGGGGG G GCGT GC T CGGC CGCGGT CGC CGG GTT GT CG GG GGG G G GG GGG GG G G G G G GGGTGG GGGG G GTT GGGG G GGA GTGGG GGGG GGGGG GGGGG G G G G G G GGG G G G GGGGGGG GTGGT TGTG GT T T TGT T TGC TG G GTGTG GTGT TG GTG GTGT T C TG GTTG G GTGTGGGT TTT T T TG GGTTTG G G GTGG GTGTGTGG GTGG G GCGGTGG G G G GCGGAT TGTGT TCTCT T T T T T T TTT T T T T TCTTTTT TTCGTGATAGTC TTGT T TATA G A GTCATATGTTGTATATC A A ATT CTCT TT CTT TTAT T T TT CTCC ACG A G GAAAGAA CCG AAA AGTATATAATAA A ATAATA G G GCCCT T C G T A G AAA A C A A AA ATAAAACGAC ACCTC CA A AG G GAGCAGGAC CCCCCCCA CCAGAGA A CCA AG C GCCAGGT TGTGTGT T T T T T T TGT TTGTGTG G G GTGTG G GTG GTG GT T C TGT T TGT TGTGTGT TGTGT T T T T TTG G G G G G G GTG G G G G GTGTG G GTGTGGGT T TGTTTTTTGGGTGATCTCCTGCAGTCGCA GATCTCTAT TATCTGT T TTT TG GTGTCTC CGCGCTCTCTCTCTCGCGCG T T T GG C A CTA C GTA CCTCA CCACA G C A C GGG G T G T G T T G TTT G T T G G C G TT T T T T T T T T TCTCTCTCT TCTCTGTCTCTCTCTC CTC C C C C G C A CT T T T T T T T T T T T T T C T T T T T T TTTTT CTTTTTTTTTTTTTTTTTT8278334712825904 1562912881 3 755014 05 1 4 425 2 8 5 2 65413141010101141 04131441943745264 911 38 861 83 94103 936 9 9946734 1 343 0 7 5 7044431469246 3182838485868788898091929394959697989990010203 4 5 6 7 8 9 0 1 2 3 47 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 8 8 8080808080808081818181818

[0028] 311813551271126 54212 5 3 9 7 474 8 3 8 1 6 3 7 473 1 8 8 5 6 1 8 40 2 6 3 3 2 649273830768 769151317666929297439 2 5 2 2 6 82 0 2 3 1 0 2 9 4 95401 7 425 7 192 0 8 3 4 7 5 3 25182414676774098 4 0 4 4 9 8 5 7 1 7 9 6 7 8 6 8 6 1 9 3 727 8 6 3 6 5 1 87650575 6 1 0 5 1 8 9 83 9 7 4 0 0 706784 4 54048336163 05622146710786590 3303307998685826 GT T GTTCTTG TTTTG TT TT T G T T T T T T T GTTCTATAGTAAATCCGGTCA GTT TC AAAT TGCCTCGTGCGCC TGTT CT T T T TC GT G C TCG GT T TTT CCAT TGCAAT TCC GTG GT TTGAAGAATT ACCCTATAA ATC CCTAGCC G A C G TCAC TC ACA TTA A AGCCAC ACCAGCACCCGA C ACT C G C C A A ACA A T A ACC ACA A ACA C ACC CCAA G GTACTGGGGGTCG GTGCGTC CGG GT CGC C TTCGGTT GC CGGC TT GCGCT TGGG GTC G G AGGG G GG G G GTCGGGGGGGG G G G GGGG GGGC G GTGTT GCG GGT TGGCGG G G GTGTG GTG GG G GT CG GTGGTGG G GTGTG GG G GTG G GG G G G G G GCGTGTGCGTG GTGG GTG GGCGGTGG G GTG G GTTG G GTT TTC CTG GTCTG G G GTGT T TTT TG G G G GTAT T TG GTCTCT T TGTGG G G G GTGG GTGG G GT CGGCT T TTT T T T T T TAT T TCTGT T TCATAATATATATTT TGTC AT T TTTATT ATTTATTTCTA TT TC AT TCTT CT TCG G GG A A ATGATA A G G ATA ATATAA A A A ATAA ATA A G ATAA GCA A AGCG G GCG A GCAGA AG ACG G AGACCCA AG G C AGAGAGAAAA A G G G AGCCC AGAGA CA C G ACAGCCA AG G GGA AGCG C A GCA C CCAGGT T C T TGC TGT TTG GAT TGTGTG G G G GTGTGT TGGT T T T TCT C TGT C T TGT TGT C TGTCT T TTG G G GTG G G G G GTG G G GTG G GTG G GTGTGCGTCCGGCT T TCTGTCTGTCTCTT GTCT TCTCTCTCTCTAT TC GT TT CAT TGCACT CTT G GTA G C T A G ATA A GCA G G CCA CTT A GCATA C GTCGTCTGGTCTTCTTTG T GTCTCTGT T T G TTCTCTCTCTGC T C T TTCTCTCTCTCT T GTC C TC G T G T T G T TTC C C C C A C C CGTAATCT T T C T T C T T C T T T T C T T T T CTTTT CTTTTTTTTTTTTTTTT C CTT86335755637959375667 25818 06 2 5 2 2 520 5 256 2 5 8 4 3 6 0 05 0 9 4 3 6 0 5 343 1 01 967541361579 13 937591 81 8 7 3 6 3 9 3 6 66 1 7 1 4 7 1 6 4 4 7 1 4 1 4 7 4 6 33401974134864643516171819102122232425262728292031323334353637 8 9 0 1 2 3 4 5 6 7 88 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8383838484848484848484848

[0029] 92709369 31 667621592 8 3 9 8 9 3 7 7 1 5 8 6 2 841 135 2 4 5 8 7 2 57 8 6 1 0 6 7 861549325005643393804434000049 2 6 4 2 4 0 1 04 7 2 3 212 3 7 4 1 9 4 0 2 4 9 3 0 3 3 5 7 649 84 51 70 91079783616940 3 7 5 5 0 9 3 0 9 7 9 3 0 9 9 2 3 6 8 1 155 2 9 6 541 7 0 4571 756 9 0 9 9 5 2 55 4 1 884 3 1 00815157979270422511107059272525 294 74409936943302 TTT T T TAT T T T TT TTT TTG T T TT TTTG G TCT T T T T T G T TCAGCAACCC GT TTT TTT TCTTTGTG GTG TA GAGCCAC GAC CGCCC TT GTGT TCT TCC GT TG TA TCGTACTGTTCGT T T TACCC T AAACCAA G T GGA C TGCA A A ACA A AC A ACA ACA CCA G G TAC AT GCACACT ACGT GAGCAAGCCC TCT AG G A C C CATCC AC TT A A ACACACA C A ACGGC C CGGGGGGGGGC CGG G GCGGTT G G GTT G TT CGGTTTT GT C CGG G GC TTCGGG GGGG G GGT G G G C GTC G G A C GTGGGG G G GGGCGGG GGGTGG G G GGTGTG GTGG GTG GTGG GTG GTGGTGGCGGTGG GTGTGGCGG G GTG GTGGTGG GCGCGG G G G GTG G GTGTGG GTGTG GG GCG GTTGGTGTGG GTTTT T T TG G GTTT GT TTTT GTGTGTG G G G G GTGT T TG G GATCTCTAT T TG G GCGTTTGTGG G G GTGGTGGTT T T T T TGTTT TCT TGTATCATCATATTGTAT TG CA GT T TATGT T T T TT CT T T TGTA CTCTGT TTT TG GAG A G A G A A A ATA ACG TG AAA GTA A ATGG A A AATGTG CACGCA ACAGCG C ACAGA CCAT G AGCCAGAA A CGAGA CG GG CAGCGCACGCCCGCCCAAGAG T G A C G AGA C A AGCCAGAGGA CC ACGATGT T T T TGT T TTGTGTG GTG G GTGT T T C T TTG G GTG G GT C T T TTG GTGTG GT T TGTCTGT T T T TGT CTGTGTGTG G G G G G GTG G CTTGGTGC G CTT GTCTC GTTTC CTTTT GTA CTT G C G TT TTT TCTCTC GTGT TCGT G A G ATT G G C A G ACACGCTCTCTCTCGCGCGCTCA TG GGC C G ACT G T GTA TGGGGGTAC CCTT TGT TTTATCGACGCTCTGTGTTTCT TT T T T T T T T T T TCT TCTCTCT TCTGTCTCT T TCTGTCTCTC C C CTC CT T T T T T T T T T T T C T T T C T T T T C C T T T TTTTTTTTT CTTTT02 227848038136723 434 79 9130 263 32 9537647 009 43 85339470421427897336 4 1 5 0 352 3 2 9 2 84597960552083 32 5 5 3 7 9 62 1 4 4 4 1 1 4 3 7 1 3 6 3 6 1 1 7 7 1 6 1 4511443561101940515253545556575859506162636465666768696071 2 3 4 5 6 7 8 9 0 1 28 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8787878787878787878888888

[0030] 53826894988 177 306064552465 9 4 7 4 1 8 4 2 7 9 4 8 2 2 24957338570475330691860598275104 81 81291494418738 622656233 2553420507024827280543359453908356696182639 00 47779729570774 935158773 2751 13375103 54857034725837261517694304514924000 9 7 6 6 9 5 7 185 83435200287310 93 TT G T T T T G TT TTTTT TG T T TCT T T T T TTT TTTGT T T T T TCT TTTGTGTGTTGT T T T T T TCTATAT TC GTT GT TG GT TGGGG AAATGGGA TGCAGGA ATACCC TCTCT TC G C GGT A C GG CGAG AAAAAC C A G GGCA T A A A AA CGC AT AAAC CCA AACCAC CCA AAGCTT C GTA C G A C G C CTA A A C A ACACACA ACAAAA CCAC CA A CCCAC CT AGC TTCGCGC CGTTCGCGCGG GCG TC CGCGG CGG G GCG G GT CGTTCGGGG A G GGGG T GGGG G GGGG G G GGGG GCC G G G GGGG G GTGGGGGGG GGG GGG G G G GGG G GGGGG G GGGGG G G G G GGG GGG GGGGGGG GGG GTGTGTGTG GT TGTGTGTGTGT CG GTGTGCGT TGT TGT T TG GTGTGGTTGGTGTG GTGG G GTGTGGTC CTTTT T T TTTTTTCTTTGTGT TCCT TGTTC GTG G GTT TATC GTGTGTGTGTGTG GTGG G GCGTGGTTATTT TT G TTTTCTCT TTCTTT TTC CTTTTTCT T TGTG TT C GTTTTTCGTGA A G A A A ATGTA A G G GTAA ATATGG A A A A ATA A GGGTATGG ATAAAGAGAG A A A ATGTGACGATGA ATGTGAC T GTGA C AT GTGTCTGCTCAA T GTGA CTGTCAGTGAT A G TTGCCCC A CT G CTCTGTCACGATGCCTCAG GTGA AGAG T A GGAGCCA AA CGCCCCTGTGT T T T CGT T C TGG G G G G G GTT T TG G GTGTGTG G GTGTG G G GTG GTGTG GTGTG G G GTG GCTTTTT TAT TT TT TT TC C AT TC C CTCT TCTTTT A GTG GTTTCTGTCTCCTCTA CCT A CTTTA G C CTA A G C CTACT G C A G CTT G G G ATT G C GCTCGCTCCCGCTCTCG G G T A G G G T T G G A G G T T A T TCT T GTCT T T T T T T T T TCTCTCTCTCTCTATCTCTCTCTC C C C C C C CTC CTCT T C T T T T C T T T T T T T T T T T T TTTTTTTTTTTTTTTTT CTTTT CTT4743373376525041411086 4 3822 3 612 0 7 2 5 6 4 7 6 253 5 3 3 24 0 9 4 0 5 6 0 5 2 32114387216 81 5560811 07931 3 4 353 3 7 9 7 13 1 7 4 1 1 7 1 4 1 4 2 1 7 4 1 6 2 10114238601144633384858687888980919293949596979899900102030405 6 7 8 9 0 1 2 3 4 5 68 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 9 9 9 9 9090909090919191919191919

[0031] 81 19 45354120565 8 2 3 3 7 8 7 4 1 9 1 3 394 93219 2 9 5 623 3 9 4 36 3 5 7 7 9783827350787818566778686571302929 8 6 3 5 3 99 909 9 2 7 7 8 0 9 7 5 5 5 8 5 3 8 6 1 2 208 12001286322 46 68006586 1 1 4 1 0 9 4 9 4 4 7 2 5 5 2 7 5 0 8 3 654 323 8 0 6 4 944473 3 1 217 8 5 0 2738 7 6 5 291209392007983733313621281579 549 9 826919978 13038273 GTTTG T T T T G T TTT G TTT T T T G T T T G T T T TTG T T GT TGG T TGGT TACT AA TTT T T TGG TT TGG TCCCAA TTCTGCGCT T T T TGCGGATTGAATAC GGT T T T TATCA TCATCATGT CT T T TG CG A TTCCATC C A A CTA A AGTAG C AAC ACC G T T G A A A CCCGA A TTCA T A A ACA CTA ACACA A A TTA AC ACACC A AG T GCA ACA TCACTCATGACCGGT CGTTGCGGGGC TGGGTCAGCGGGGCGG TCG GCGC CTCGGTGTTCGGCG GTTC CGTTGAGGG G GGGGGCTGG G G G A G GGGG G AGGG CG GGTGG G G GGTGCGTG GG GTG GG G GTGTGTGT G GGGG GTG GGTGG G GTGTG G GG GTGG G GTGTG GTGG GCGTGG G GTG GTGGTGG G GTG GTGCTGATG GTGGTGG G G GTGGTGG G GTGTGGTAT T T TTT TCT T TAT TTT TATCTTT T TG GCCT TG G G G GTGG G GTTT T TCT TGT T TCTGTGTGTATCCATCATTATATTATGTCATGAT TTTCG AT T T TTA AT TCTGTC AT TATC AT TCTT CTATAA G A G GTA ATGATA A ATAGTA G G ATAA ACG G CCACGA CA ACA AC TGC CTC CAA GGCCACAA AGAGA AAGAG A G AGC AT ACA AGCCCC A ACC AGAA G G A GGCCCCA CCAG T G AGA CCA CCGTGTGT TGG GT T T TCT TG GTG GT T TGTG G GT TGT T T TGTGT T T TCT T T T TGT T TGT TGT TTG GTG G GTGTG G GTG GTG G GTG GTG G G G G G GTTTTC GTGTT CTCTT GTGT TC C GT TGTAGTTTT GTC CT TAT T T TCTA T CCA G C G C A GTT CTT C G GTACT C C G T A G C GTC CGGTAAATA CGATCT GCTATTCTTTCTTTCG GTTCTTGG A T T GTTCCTCTTCTTCTTGT G G T T T GTTCCTCTTCTTCTTCTTC GG G TTTTTC C GA TCTTTTTC TG G T G T TCTTTC C C C C CC T GCTTTTTTTTTTTC C ACTTTTTC145139 87845 507 02715 35123 516103 7 884 6 2 465 510 0 2 4 45 7 6 813 1 225 8 1 796 0 012 3242006 22 93551 591 3 222 8 7 7 8 76 2 7 4 4 6 2 4 7 1 1 4 4 1 7 1 6729741431497033446718191021222324252627282920313233343536373839 0 1 2 3 4 5 6 7 8 9 09 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9394949494949494949494959

[0032] 49 29 79598335658672377 3 8 4 7 5 7 2 872 3 2 3 4 3 1 8 6 8 2 2 3 9 21 4 4 4 8 9 0 1 2974652100049361216528348757 3 1 9 0 0 6 2 3 81 149 8 4 9 1 5 7 4 9 8 9 9 2 0 8 2 7 917 2 2 378302254330339470933 9 3 0 5 8 0 1 3 1 3 2 5 1 8 4 7 4 7 0 753 907 5 8 2 2 2 9 44 8 4 6 3 2 5 7 5 7 6 3370 1 0 0 8 4 3234221183715738231953 0443019040072605635939565675 TT T CCTT GTGTTCTTT TT T T T G TGT T T T T T TTCTTT TC TTTTTATATGTTTGTT T T T TTT TTTCT T T TCTC GT TTTC GTTGGGACCAA C ACA T GGGTCACCC C T TCCCAGTAATC C TGTCACGAACA GCTAC CTCAC AGAGA TGCGTACA A AA G A C CGGTTCA A ACA C A ACA A AC G A G AAATCCACACAT A ACACGT A G ACA A A ACACAA CCCA ATATTGCGCGGC CGC TTCGCGCGCG G GCGTGCGC CG G GCGCGCG GGATC G G G GGGGGGGGAGGG GGGGGGG G G G GTC G GGGGGG G G G GGGGGTGGTGG GTG GG G GTGTGTGG G GTG G GG GTG GG GCG GG GTG G GT G G G GGGTGTGG G GTGTGTGG G G GTGTG G GGTGGTGG GTGGTGTGGTGATGTG G G GTTTTGTTT TTC TT T TGTGGTGGTGTGTGGTCTA CT T TTT C CT TTG C GTT TCCT T T TTC C G GTTGCTGCTG G G G GTGTGG G GTTTTAT T TTTTATTTTTT T TTC TTTT TTCTT GTTGTTTGTTTTTACG ATAG GTAATATA ATGATA GTATA GTA A A A G A G ATAA G G G G ATAAAAA T GGTGA C AG C G T T G T GTG GA CCAGCCCCAGC AT G G G AGA A A A CT ACCCAAGAGGAC A GGCCCCACGCC C GCCCA AG GGCCAA A AGA AGCGTGTCC TGT T T T T TCT TGTGTGTGT T T T T T C T T TGT T T TGT TCTCTG G GTG G G GTG G G G G G GTGGTG G GTGTG G GTGTG G G GTGTG G GACTGTTTCTGT T TGCTGTCGCTATTGCT TGCTCT TATTTT TGTTTTGTGCTGCCGTGGGCTGTAGGCTGCT TCCAACTGAT TGTACTCTT G T T T T A T G A T T T T T T T G T G CGC C G C C C C C C CT T A T G G T G G G T G TT T TAT T T T T T T TCTGTCTCTCTCTCTCTCTCTC C A C C C C C C C C C CT T C T T T T T T T T T T T T T T T T T TTTTTTTTTTTTTTTTTTTTTTTTTTT02511835493729 8 455 54916 8 50 6 206 7 0 5 5 1 03160 0 0 653431675614015 023765 133119 67943 3021032141 4 7 515 9 9 9 9941453561431 1 23 141 241 3 6313144 4152535455565758595061626364656667686960717273 4 5 6 7 8 9 0 1 2 3 49 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9797979797979798989898989

[0033] 34253855382632379 3 2 6 5 916 4 5 1 129 2 1 838 7 2 4 418 8 3 4 1 74 4 5 5 7 9 0 9313139453265064556816097940254780 6 4 1 6 71 9 4 9 1 6 9 8 7 788015 930 0 8 2 0 33 22 3 4 6 5 0 1 8 9 7 0 5 7 8 6 4 8 1 4 5 08 269268141609299947 1 3 222 8 4 0 656 1 6 987 5 1 2 874 7 2 7 4 04 4 3 2 2 1 8 7 5 1415986549 125919788 6202787 644371496 9141505019 CGTC TT G T TTT TG TTG T TTGTT T G T T TTT T G T TCT T TTT TTTCTAT T T TTTGTTG GA CTGT TTTG GT TTT T T TCTTTTT T TGT TCT TC TT TGCGTCGTGGT GGT T AAC GCTGTG GC G A GCTT C CCACTGCACC GGGAA A T TGTAT C G G A GAACC A G CCC C G C A G A TTT TAAT ACT C GTATCCCA TTAC CA ACT A AC C TA ACT A A A ACACACT A A CCA ACA ACACCGTGGT GCT GG T G GCGTTCGG G TCGGTTCGC CGG G GTTC CGTT GCGGCG GGG GG AGG GGGG CGG G GGAGG G G GGGG GGG G AGGG C GGG GGGG GTGGGTGTGGTG GG GT TGTGG GTG GTGG GCGTGTGTGG G GCGTGTGG G GCGTG GGGG GGG G GTGT T TGT CG GTGTGG GTGTGG GTG GGTGTTG G GCTTCT TG GGT TG GTCTATC G G GTTTTG G GTT TTTGCTC GTGTG G G G GCTAT T T TGCTG GTGG G GCTCTTT T TTTG GTCT TG G GAT TCTTATCT TCT T T TCT T TCT T T TT CCACTA G A AGG AAA A AAA A AGAT T T TCAG A A ATCATATAT T TTTCT T TAT TCT TAAAATA A A A GAA GTA A GTCACCG TCCC AT GA AACGA A AC GCGCA C CC C A AGAA CCGC AA G C AA CTG CAGAGCCC GAGG G C G G GCC C CAGCC C C G G GAGC C GCCAGCC G CGTTGT T TGTGTGTG GTTGT T T C TTGTG GTGTGT TTGTGCTGT TTGTGC T T TTGTG G GTTGT TTGTGC T TTGTG GTTGT T T T T TTGTG G G GTGTCG C CTT GGG CTT TAC G C G G C G CTCTAG G C G CTT C CGCTCTTTC G GGGTATATAT TGTGATT GATGTCGC GTG G ATA C G G A G TTT GGG A A T T GG C G C C G C C C C G C CGC GCCTC ATCTCTCGCGCTC GTCGCACTCT T G GT T T T T T T TTTTTTTCTTTTTTTCTT TTC T T T T T TTA C C C CT T T T T C TT T T T T T TCTTTTTTTTTTTTTTTTTT46148525243515112 1 4775607778425577398252758 6597963594616911355215260486443486344 639559724973324863453243 4150467013156435444119341586 7 8 9 0 1 2 3 4 5 6 7 8 90 1 2 3 4 5 6 7 8 9 0 1 298989898999999999999999999999 000 0 0 0 0 0 0 0 0 1 1 13141516171811010101010101010101010101010101010101

[0034] 314422118887951029528498322 8 9 2 9 2 1 9 8 5 8 942131048033 54711245532409 5 8723051 2 332 7 1 4 9 2 579085 9 2 4 0 5304472 1 3 6 1 6 1 1 7 8 454 5 5 8 8 1 8 5 057 8 128 7210400078910 756540266072933963691211216215992727 1 6 9 1 8 9 5 805433209264505840433 2 2 082 3029 8 7 6 4 1 6 1 6 551 4740489442908059 89 TTTCTTTT TGTTT CGG TTT T T TTT TT T TGTT TT C TTTG T T G T T GGTG TCTTTT CAA G T T TG TC GTTTATATATCTC G A AT TG G C TT T T T TCT TGG C TC A C G A CACA C C CAGGGAACA TTGAGAAGAACGCGAGACCACATCAC ACACA A GC A TC CC CTAGCAA A CCA ACAA ACACAG CCACACACAGCAAGT AACT A AC TT ACCAC A ATCTA C C TTA A T ACA TTG GG GGGG G G GGTT T G GCGG G G G G G G G GTTCGGTT G G TCGCGTT GCGTCG GG GG G GG GG GA CGGGG GGG GGGGGGGG G GGG GGGG GGG GG G G GG GGGGGGGGGGGG G G T GGG GGGG GGGGGGCGGG G A G GGG G G GGGGGGT GT TGT T T TGGT C T TGT T T T T T T TGTGT TGT T C TGT CG GTG GT T T TGT TGTTTATGGTGCTGTT TG GC GTTTGCTGTTG G GATCTCTG GGTCTG GCTCTTTCTGGTG G GGTTT TGTT TGC GTGTGCTG G G GTTT TCTGTCTGTGATCAGT T T TGAGAAA GT TGA ATCAT T T T T TAAAA AAGTG GT T TATGGCGGGGT TTT T T TAG AGA ATA GT TGGCATCT T TCTGA ATA A G AACATGA A AGC ATC C A ACA A CCC A C A A AAA AGAAC A A C AACGAACTC CCGTGGTG GGTGTC GGTGTC CTGGCGGTG G G CGTGT T TC G CGTGTGTG GGT TGCGGTG G C GGT C T TC G G CGT TG C G C CCGTGTGGTGT T T TGTCT T T T T T T TAC A GT TGTGT T T T T T TATGTGTGT T T T T TG G G GGT T T T T TGTGCTCC G C CGATCTATCTGTTGG CTGTAC C G TCTTCTGTCC TGGTGTAGTGG T TGGTCTTT G TTTTGTATTACAA GC T CTA A TTTACA GGTCTTC C C C C GTTTTTTTTTTTTGCTC C C C C C C C C C C C A C C CTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTCTTGT T C TTTCCTCTTATTCTTCTTGTTC14 4 0994351 745619500 58221 6 808 2675856881488935547318 6 0 2 3 85 13113 4 5 1179324353 2 1 9 7 1 74 4 3 456861451433453211443671104867234863454676154569102122232425262728 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 20 0 0 0 0 0 0 0 02020303030303030303030304 4 4 4 4 4 4 4 4 4 5 5 51 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 101010101010101010101010101

[0035] 36 792 223728884779278573563317525 1 8 4 1 6 7 4 9 5 9 6 8 4 8 2 7 1 9 8 5 81601142975090053933427105730217 1 2 9 8 5 3 457349290 4 3 2 6 9 1 3 9 5 9 6 8 8 7 0 2 6 0 5 8 37823510648993823 2354779 81568344248237937729744231210202286 3 9 4 4 9 8 6 6 2 6 0 3 6 2 7 5 7 75150681716545111205998689161112625234929 84 TTGCG T TGTGGT T TCTTTT TGT TCT TGGTT TCTGTT T TAT TG T G TCT T T T TG GCT TT T TTTCTATG T T TCT T TTT TTTTC ATC TTTAAC AC C A GCAG A G T AGT CGAG GCTGATCCGTT C T AG ACA A C C G G GTGACGC GCT T T CTTTAG A A G CCACA A A AGCACCACCAC T CCCA ACAG CTAC TCCTAG T T CCCTCTACAACACACCTG G G ATA ACACAC GCACAC GA TTGC TT T G GCGCGC CGCGG G G GCGGCGTT G T G T T G G G G TCGG TG G G G G GCGGG G G G GGG G G G G G T G TGGGAGTGG GGGGGGGG G G GGG GGGG GGGG GGGG G GGGGGGGGG GGG GGGGG G G GGGG G G GG GGGGGGGGGTGTTGT CGT TGTGTGT TGT T TGT TGT T T C T C C T T T TGCGGT T T T T TGGTCTTT GTTTGATG GCTG GATTT T TGC TTGCTGGTG G G G G GATTTTTTTCTCTGCTGCTGTTG GCTCTGCTTTGTA GTG G GTTTT TGTTCTA GTATAAT TCGACAT T TTT T TAGAA ATA A GT T T T T T T T TGG G AGA AGA A A ATCATGAT T T TGACATATAT TGGGAT TGT TGA AAG AT TATGATGGGCA C A AAA ACCTA AGAAA AAA ACAGACA C A A C C A A A AGC ATC A A ATCGTCCTGTG G G C G GTG G G G G G G G CCGTGTCCCTGTG G GCC G C GTG G CG G G GTGT TGT TGTGT TGT TGTGT TG G G G G GTGTGGT TGTGGTGTGTTGT T TG G GTG G G GT T T T T T TGT TGGGT T T T T T T T T T T T TGGG CATCC C T T TGT T T C TAC TTT CTGACCACTGCGGGG CCTT T T T TCC G T CGG C CTTGT C GTTATATAT GACATGTTT GAT TAC G G T G G AGT G GATCAGTG A TTG C G C C C C C C C C C C G G G GG T A TTTCTCTC C G CCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTTTCTCCTCTTCTTCTTTTCCTCTTCTTCTTCTTCTTCTTT09351053 232531152315492 392 5330825479706164823763 3 004 4 5 51 9 8 7 110 3 1355 401 1 0 664 7 9 4 86 7 6 7 1 4543431514401346741569756311314675463210472113545556575859506162 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 60 0 0 0 0 0 0 0 06060606060606060707070707 7 7 7 7 7 8 8 8 8 8 8 81 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 101010101010101010101010101

[0036] 60 2946197435988296 7 4 8 5 419 1 2 4 376 3 2 7 9 3 4 387 774 7 8 8 83 7 3 2 2 6 2 560213964496231969738461359970510485 6 8 6 86 9 9 2 1 2 4 0 6 628594 173 0 9 6 27 5777 5 8 4 9 0 7 8 6 1 5 1 1 7 8 0 8 5 1 6 6182784938871419020 6 033 9 1 0 458 1 0 4 3 5 5 257 645 4 4 1 745 0 8 7 5 5 4 1 0 71766462 423089981 572562585343189 769 33626818 TTT TCTTT GTT TC TT T T T TTTTTTTTT T TT TG G T GTT T TTCTCGTGTCT TGG GTGTTGTGTT TTTGTAT T T TT CTT G T GT TG TT TAT TC GTGTCAT ACCGCCCC AGTAC C C G A ATCGAC AC TCGAC GGAT C CGCACAGTGAA AACCAC CACCCCT A TTACACAC GCA GCCAGACAG G G CCACACACACCAA C C ACA A AC GCA ACAC CT TC GTA TTAG C ACACACACGACGTT G G G TTT GCGTT GC CGG G G G G G GCGG G GTGT TCCG T G G G GGGGGG A G GGG CGGA G G C GGGG G G G GGG GGGGG G G GGGTGGG CGGGG G GG GTGG G GCGTGTGTGTG GGGGGG GGG G GGGGGGGG GGGGGGGG G G GGG GGGGGGGT TGT TGTGT TGTGT T T T T T T T T T T TGT CGGT C TGT T TGTGTTG G GTTTTT T TGG GTCTG GCTTTG G GTTTTCTG G G G GGT T TCTATGCTGATGGTG G G GGTCTTT TTTGGTATC G GT TG G GTT TT A ATCTC CATATCT T TACCA A G GT TCT AGTAT T T T TCTTT T T T T T T T TGT T TGATAGG A GAA A A ACATAAGAGGATG G GGGTGA AT TG AG ATGGT T TGG G GACTCCTCAA A C A C ATCCC CA TCGC C A C C A ACCAA A C CTC C G GTCTGCCTG C C CCTC C C CTGTCTC G G CCC G G CTC TCCCAGACGCTCAGAGGTGTTGT TCTGTGTGTGTG GTGTGTGT T TG G GTGT TGTGT T TGG GTGCGTGTGT TG TA AT T T TGT TGTGTGT T T T TGT T TGTGT T T TGT T T TGT TTGCGT T GTATTTGTGCGACTGC C C G T C C G G CAACGTATGTTTACATGTGTGCAAC CGATCA C C G CGACTTATGTCGGCGCCCCACCCATGCGTT C A C C C GTTTTTTTTTTTTTTCCTC C CCTTTTTC C C C C C C C C C C C C C G GG GCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTTG G T GTTCCTCTTCTTCTTT0498 503070992666551 26200455260060804 462 8213 6 6 6 0304 72 61 1 248 0 7417 9 3 8 6 632 09532 7 11 6 6 114419776518634116154240453441311441446566734317888980919293949596 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 00 0 0 0 0 0 0 0 09090909001010101010101010 0 1 1 1 1 1 1 1 1 1 1 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 111111111111111111111111111

[0037] 818456806775669 6 7 1 58786 7 783 6 2 587 4 8 133 2 9 8 7 4 9 7 6 56 0 3 9 7 5 55928829172063592589777213705563187857 5 7 40 1 4 0 9 8 1 6 8 3561956388 1 0 6 10 1 99 7 4 8 2 5 8 9 9 3 9 4 3 8 7 7 7 8 3 30 6 3139943031923924401087 9 149 7 2 701 6 9 166 9 6 3 7 7 4 0 4 36 4 4 3 0 0 9 6 6 5 1217 6 40595 0722615 5948084 552584430101905009 TTTTCTTTTTTTTT T T TT TTTTTTT TTTTT G TTG G TTT T TT T C TT TGT A C C G GT TAATTCAC C CT CT TGTA GT TT GTT GTCTGAT TTTAT TG G GT TTCAGA CT CCGC AAG T A C C T CACCC G GGCGCA CGTA CC AAT T C G GCAGCA ACACACAACA GAC CATAT AC GC CACA AACA GGG A GTACGA AGACAG ACA TCTAACCG CTC AG C C GCA ACA ACACCT T ACA ACGGCGGGGGGGGG GGGTT G GGGCG CTT G A G GCGTGG TTT GCGGCGG GTTCGGGG GGGGGGA GGGGGGGGGC G GGG GGGGGGAGT GGG G G G GGGT G GTGG GGTGTGTGTGTGTGG GGTGTG GGT TGGG GG GGGGGGGGG G GGGGG GGGGG GG G GGGTGT T TGT T T T T T CGTTG G G G GC C TGGT T T T TGGCGT TGTTATCTATGCTGTGGTG GGT T TGT CTG GCT TGGTG G GCTCTTTGTTGCTGCT T TGA A CTGCTCTG GGTCTG GATTTTTC GTG GTT TCGTCATATAT T TGTCT T TATTT T TCA CAAGAGGAA AGG A GAAT T TCA ATAT TAGCAT TAA ATGGTGAT T T T T T TAA ATTT TGGGG GTACGAGA ATACAATGCCCCA A A ACCGA AACTC A CAC A C C AAC A A A C ACC C A C ACC CACGT T TG G GTG C G GTC C G CCC GTCTCTGTC GTG GCC G C CTA CTGTC C CTGCTGTGTTGTTGTGT T TTGTGTGTGTTGT TGG GCG G G GTGTGGCGTGTGTGG GTGTGTG AT C C AT T T TGAT T TAT TGT T T T T TGT T T TCT T T TTTTATCTGATAAG A T CCGTCTATTTGT T TGGTTTAAGC CGTTCGGG G T G A CGGTGTACGTACCCTTT C CTGTATGTAAAGAGGCTACCC C C C C C C C T C C C C C C G GG G TTG GT TC CTC C C C CTTCC TTCTC C C C C CC T T T T T TTC CTTTTTTTTTTTTTTT CTTTTTTTTTTTT CTTTTTTTTT T T T T T T TCTTTT559340 600042986431357 535048854517911650205296 045 2 2 3 0 55 154015 84172511 7443860121 419 4517216561634146197928756 3 459 7 2 6 5745372412176 6911222324252627282920 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 41 1 1 1 1 1 1 1 13131313131313131313141414 4 4 4 4 4 4 4 5 5 5 5 51 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 111111111111111111111111111

[0038] 116176411416652974045009 5862984 6 482 6 8 4 3 2 5 2 3 6 8 3 6 3517332526941300938143652349122 8 1166 28 408621 643033121 6 0 9 7 6 0 513 4 9 1 6 3 1 8 8 2 0 8 7 4 1 22 0934 44 747199 5518861264359813545132925296 542 8186149 0 2 7 1 5 1 1 5 8 4 4 76077574723109937552554437180 9 7 938 4897 7 1 3 298 706779 27 CGTT T G T T T G G T T GTT T T G TTT TTT TTT TTTTG TTGT TGTTTTGCTCT TTC CGTCT T T T TTAGGAA GTTGGAGTTCTGTATTCTTACT TGTCTTC CTG TC GTT CTC G CTCTGTGTCAA C ACG A A A CGCATTAGGACTTTACCG TTC GCTAC GAGAGCCCC C A GTACACTTAC C C TCACACGGTTTA ATCACCACAG TCA AA A CCACACA ACA CCAACCCT G CTAC GT ACGG C T GC CGG TGTT T G G TGG GTGGGGCG G G A TCGGGG G GCGG G G GTT G TTT GTT GGGGG G C CGG G GGGG GGG GG G G C GGGGGGGGGGGGGG GGGGGGG GGG GG GG GG GG G GGG GT GGGGGGGGGGGC GGG GCGG GGGCGGT C TTG G GTGTGT T T T T CGGT T T T CGT TGT T TGGT T T T T T TGTGT T T TGTT TTT ATGCTT GTGTGTGCTG GATTTTTGATG G GATATTTGTTGCT TGA CTGT TG GTG GTGTGTGTG GTGT TTC C GTA GTC T CTT C CTC G C GAT T TAG ACC GATAA CTTT T T T T TAA A A AAAAAAAT T T T TTG A ACACATAG AT T TGGCACGT T T T TGA GAACAGAT TAACATGAT T T TGA G AAGGCCCCA CGCACCGCACGC C C C CGT C TC C C CCCTCTC GCACGAACCC AAC A C A AAC A C A A C A AGCAC C ATCTGCC GTCTA G C G CTG GTC G G C C CCGTG GTTGT TGT T TGG G G GT TGG G GTG GTGTGT TGTGGCGTGCGTGTGGTG CC C CTGTGT T T T TTTGGT T T TGAT T TAT T TGTGT T T T T T T T T T TGTTA GG T C CGGTTTTTTG GTGTGTGGGC T CGTTGTAGGCGACTTTGAGGCGCC T C G CGGTATATGTAGCATACGGCCAC G ATATG CCGAT CTT A C C C G T C C G C C C GAC CTCGT T T TCTC C C C C C C C C C G CT T T T T T T TTCTCC TTCCTTTT CTTTTTT C CTTTTTTTTTTTTTT CTTTTTTTTT T T T T T T T TCTT16592977445434754137987636 2 62946180793 2 3509317802 8 2 7 0 3 564611575614111 71568624315601 3661 3697112141 15359 6 7 6 2 1 68444245191466397863446 555657585950616263 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 81 1 1 1 1 1 1 1616161616161617171717171717 7 7 7 8 8 8 8 8 8 8 8 81 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 111111111111111111111111111

[0039] 3633 16 9856 87 5374376921838 4 3 3 2 4 6 2 1 9 3 4 8 1 5 8 5 6 7 2 9 43 6 4 9 9 7 6 4 181545465858243445727934 40664613023 4 9 2 38 1 843 7 799 2 3 0 7 4 2912 7 4 1 4 21 8 96 2 2 6 7 7 3 7 6 9 5 0 9 8 1 2 7 4 1 48 2 54862 28 531248420081 35 9737125 0 8 9 9 2 5 0 3 6 5 5 9 2 9 3 7 51 061 056 6 4 0 8 743 3 3404726248322123929780694331866353389 TT GTGTT T T T T T T G T GC CGTTTTTTT T T T TTT T G T TTTTT TTACTGGCT TAT TT TC GACAT TCCCTT T TGGCGGTTGTCTC TT C GGTTAG GAT TCCT TATATTCT GT TTT T TGTGTTAT A C G G C G T C T T TT TTC AG TTGACC AAT GCAGCCTA ACA ACA ACACCTAGT CCTATCTAAACAAACAC C A TTACACAACACCAG CTCA AA GAA ACC A A AG ACA AG GCA ACGG TCGGCGGCGG G T GTTTTTT G G GTT G G G G GCGGTTCGCGCGGCGGGG GGG GG G G G G G G G GGCGT C G GGG C G G GGGGGGG GGGG G G GGG GGG GGTGGTGG GTG GG GGGG GGGGGGG GG GGGGGGGG GGGGG G GGGGGG GGGGGGTG GT T T TGT T T C T CGT T T T TGC T T TGTGTGT T CGTGT TGT TGT TTTTTTA GTG G GTTGT TG GCT TG GCTATGTTGGTG GCTTTG GTTTTG G G GTTCT TCTCTGTGTTG GCTCTG G G GATCTAT TG GCT TG GGTCTGAT TTAT T T TAT T T TAT T T T T TCGT T T T TGTATAT T T TAT TCT T T TGAAG CG G G AAA ACGGGCACA ATAC AACA AAAC G G AG G A ATA GTA G A GCGA CTATCTC ATC ATA C C CAC C A A CCC A C A A AACGCCC ACAC AACC CTG CCG C C G C ATA CCCTCCC CTA GTCTC G CTG GTG C C C GCCGAGG C CGTTGGTGT T TGTGTGTGGTG G GTGGTGG GC TGTGTGT TGTGT T TGT T TGTGC GT T T T T TGT T T T T TAT T TGTGT TGT T TGT T TGTGT TGTGT T TGTTACGC C C G TGTTGTACTCAG C CAGTATCCGGG CGGTATGCACAGCG TGGTTTTCCGGC CGACGG C CGGTATCTGCC T G C T CGA T G T A CGGCTC G C C C C C C C C C A G G CT T T T C G TTTTTCTTTTTTTTTTTTTTTCTTTACTTTC C CCTTTTTTTCCTCTTCTTCTTCTTCTTCTTTTCCTCTTCTTCTTCTTCTTCTTT34101721 506230210298742007223 4 186641799557 9 060 7 8 808751 5 5 643111 6 4 422 7 3 4 269 491 04 1 601612282244446418686762456315121145446341114513498091929394959697 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 21 1 1 1 1 1 1 1919191020202020202020202021 1 1 1 1 1 1 1 1 1 2 2 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 121212121212121212121212121

[0040] 24 10 2094411376193 3 7 9 8 1 6 6 7 430 8 8 196 7 6 55437 7 7 8 9 7 59 4 4 0 4461920015 3802830376969047435833036342019834 908 0 6 2 1 27739679622739 85 5 69 9 8 0 2 4 6 7 6 4 7 3 1 7 0 3 3 2 5 06 354 6934938 3714 7435909 8 6 9 0 212 7 7 798 0 3 74685 3 2 5 1 0 2502 9 8 7 79 93 0 08879988424138 8099197 8767767 7 258059093887 TTT G T TTT G T TCT T TTTT T T G T T TT T CT T T T G TT T TT G TT TT TTCC TT TCC GCAGT T TGC CGTTCGCT GATCCT TCCACT TATCATAGCAAG GTT T TTACAT T TCACGCATG TACGT T TGGTGGGGTGT A TGCTAA TCA CC GAGC TAT A G A CAGCACA TTA AC CAC C C A C CCACA ACCTACACCAGCA ACTCGAGAC C GCACACTCTACAGCAG G CCA C G A ACT GAACGG TAG GCGTCGG G G GCGG T G G G GTTCGG G G TAG GGGC T GGT A GCGGGGG G G G G G GGGGG GGGG G G CGG GGGGGGG G G G GGGGGGGG AGC GGGG GGTGGT CGGGG GGG GGG GGGG GGGGGG G GGGG GGGGGGG G G GGGGGGGGTG GT TGT CGT T TGT TGT T TGT T T T CGT T T T TGT TGTGT C C TGGT TCT TG G G GTT ATCTCTTTG GCT TGATT GTGCTG GAT TTTGATGGTGTTGATT GTG G G GTGCT TTTCTC TT TGTG GTC CTGT TGCTTTC G GTTGAT TTA AT T T T T T TC AGTA G ACA GAGT TGT T TCAAG G ATAT TAG ATCATGATGT T T TAA G A ATCATAC GACGTTGGT T T TGTT TAA ACAC AA GAGA A CACTC CCAA A AAATC C AGC A A AACCC A A C ATG GCC C C C G G GTG G C CTG C ATG GTC C G ATCTGA A CTC C C AGCGCGATGTC C CCCCGTC GGTGTGTGTGCGT TGTGT TGCGTGGTGGTGT TGG G G G GTGTGG G GT TTGGT T T T T TGTGT T TGTGT TGC G GT T T T TGAT T T T T TGT TGT T T TCTGTGTTTTGTTATGAC CAATAT T G AATTATGTAT TCCTATGTGAC GCATGCAAAGTGTC C G CTTTGTGTAGGGTGTGCGAC GAATGTGAGTTCTC C A C C C C C C C C C C C G C G G CG G T TT T T T TC C CTC C C CT T TTC C C CC T T T TTC C C CT T C TTTTT CTTTTTTTTTTTTTTTTTTTTTTTT CTTT T T T T T TCTTTTTTTT29 614 6529559 572430427646863352531779508 021 27539005 7 7 3 7 9 70 799 078 5 6 694 1 4276 6 1 1 9 1 5 74 7 2 4 6 4 49243543177542372215611249704318254861631110132425262728292031 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 62 2 2 2 2 2 2 2323232323232323232424242424 4 4 4 4 4 5 5 5 5 5 5 51 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 121212121212121212121212121

[0041] 7716883261587761911 6 6 8 5 5 1 2 8 1 9 2 8 234 3 4 4 263 688 1618 2 7 7 9 9 1 1 05662983058141347196704864671683 2 4 1 9736 5 0 3 8 2 8 6 2 00 4 5 790 063 504 96 16 5 4 1 3 8 2 5 8 4 1 4 1 8 6 2 1 5 2 4 35 57728377195036895752 1 5 6 3 2 2 2 8 2 1 829 2 9 5 833 611 018 00 0 9 6 5 5 3 1 0 7 61504022010588381519010492 983877832 212 28. 92 TT TT T G T T T TA GT TT TT T TT TT TT TTT TTT TCT T T T T G T G T T TCCGTGGAAT T TAG T CTCTG ATAACGC GT TG TCC TT TTT TCGT ATCG C CT TGATTT TGT T TAT T T T TGTTTTGCTCTAGTGGCA G TAAGG C CA AC GTCCAA T CCAG G GCC A AT TCAGTTCGGCAT GTCAG GCAGC TTTAG AAA GT GTT AGT CA ATCGC CA A AC AGCCACAA G A G AACGGA A C A TGGCGGCGG G GCC A A A GGT GA T A TTACACACTCGCGCAC T CGT G G GGGGGG G CGG GGG GGG GG GG GG G G GGG GGG G GGG G T G GGGGGGTC G CGG G GGT TGGTGTGGTGTGGTGTGGTGTGGTGG GGGCGTGT TGTGG GTGTG GGT TGG GGG G G GGG G GGGGGGGGTGT TGTGTGT CGTGCGT T T T TGGTTGC CTG GTTCTATGTG GTTTTATG GTATTTTGTCTGTCTG G G GGT TCT TA GTGTG GCT T TG G G G G G G G G G GC GTTTTTCT T TGCT TCT T TC TTG GATGTCGT TAT TCT TAT TCT T TGT T TGT TTT TTTCT T TAT T TA AGAC AAG ACA GAAC GACG A ACA GAA GTA GGAGA ACG G A AAG A GGGTG GACTGAGCCA C C A AGCCC CCACTC AACGA A AAA CC TCGCC TCAC A AGATGCC CCA CTCTGGTG C C C G CTC G C G GTG G CCC CCC CAGC C GCGCC GTGTCTGTTG GTT TGTGTGTGTTGTTGT TTGTGTTG GT TT TGTGT TTGTGTGT T CTGTGTGT TTGTGT CTGTGT TTG GTTGTGTTGT TTGTGTAGTAG C GGCTTTGT CTATGGGCG CGGTCT C C T AGACATAATTGA CGCTCT C G C C C T CGATTTGTTAC GTA CTCTTGTTTAC CCA GTACTATACTC C C G C C C C C TTCT G T G TAT G T GTTTTTTTTCCTTTTTTTTTTTTTC C C C C C C C C C C C C T C C A C C CCTTTTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTCTTTTTTTTTT00 03338011462 999 1564253 71314049017792 6 5 305 6 3 5 1 4 4 6558474 9311864441 11 74618682 945 3 9 4315354011471434654 2 459 1 8 5 9 5 593160156548754 57585950616263646566 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 02 2 2 2 2 2 2 2 26262626272727272727272727 7 8 8 8 8 8 8 8 8 8 8 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 121212121212121212121212121

[0042] 364025 63 31291650 71 296 5 2 457 9 5 6 958 1 3 7 5 4 2 2 5 2 5 3 2 3 74 9 5 1 0 8 8 070347227539880499343967781657806613 3 8 7 30 3 4 095 7 5 7 731 8 6 3260 5 6 2 8 27 7 58 5 1 4 4 3 6 7 3 0 8 0 6 4 8 2 7 5 3 16 7 5 48 89820236 61 5992118574 37 2 6 8 102 9 3 0 5 1 9 4 7 7 8 7 0 2 12 0 807 6 5 100 8 8 1 08 661493128 2120203948288616435129841025 TT TTTGTT T GTT T G G T TTT T T T T TTT G GTT TT TT TT TT T T TG CTC GTTT T T TTTC G AGGCA GCT GTGACCTCT TGTGCT TGTTTTTA TTAT T TCT TA GT T T TAAAAAGA CAT G A ACAT G G G G GT GACT GTC C ACA GCCTCT AAGAA A GAC C A CCA AAA AAT A C GAAC T G G TAA G CAT A T AAC C CCCC A AG G GTT GTTC CCCACACCT TAC CACACACAC CA TTC ACA AC CA ACACACGGTT GGG G T T G GCGG G G G GCGTTTCGGCGG GCGG G GGGGGGC GGTGG G AGG G G GGGG GGG GGG G G GGG CGG G GGG G GGG G GGGG GG GGG GG GT T TGT TGGGGGGGGG GGGGGGGGGGGGGGGGGGGG GGGG GGGGGGCGT T C TGT T C CGT TGGT T T T T TGT C CGT TGGT T TGT T T TGGTTGA CTGTT TGTTC CTG G GCT T TGCTC GTGTTGGTCTGAT TG GG CTTTGTTG G GCTATTTG GCTATGCTGCT TG G GAT TG G GCTT GTCTTTGCTGA ATC AAT TCA ATTT T T TGAC A AC CA ATACGT T T TAG G AAAT TAG AT TAATAT T T TCAAG ATAT TGG ATCT T T T T T T T TCA A GTA ACGGA ATGGGTCTGC A CCC C C AGACA A CCC C A A ACC C AAC CGCCC ACC A ATC C A ATGTC GTCCC CTC G G A G CCC CTG GTG C CTG C CTC C GTC ATG C CTG GGTGTTGTTGTGTGTTG GCGTGT T CGGTGTGGTGTGGTGTGTGTGTGGTGTGGT TTG CT T T TGTGT T TGCT TGT T T T T TGT TGGT T T T T T T TGTGTTAG TCGTTGTTAGC CATTCCGTATCC C CATTTTTTGCATTGT G C TGATGTGTAG TAGTGTCCTGTTAC G A CTTTGTCTCC CGCTAGCTACTC C C G C T C C G C C C C A C C C C GC G T TT T T T T T TC C C C CT TTG C C C C C C C C CT TTT CTT CTTTT CTTTTTT C CTTTTTTTTTTTTTTT TCTTTTTTTTTTTTTTTTTTTT655 1 8 5 0 103 0 6 2 7 4 8 1 1 015 4 5 4 9 3 7 1 603 574 81499045644751 91 45076 3 8 5 8 9 3 903 7 7 8 9 1 2 5 2 521 7 381 2 01 2 4 6 2 6 1 6 301116776113134048224135386861114534361440119293949596979899 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 42 2 2 2 2 2 2 2920303030303030303030313131 1 1 1 1 1 1 1 2 2 2 2 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 131313131313131313131313131

[0043] 1140155980651789649 8 4 9 5 2 8 1 3 337 319 2 3 7 2 5 7 828 3 2 1 55 6 4 7 7 3 2 7 0404807854049080501600443660033398 2 4 9 5 46 6 7 6 5 2 1 1 5 5 0 8180 1 430 5 6 6 84 2 30 2 8 7 3 6 7 8 8 3 7 2 7 7 8 0 1 0 7 49 6 1989556276103448823060 4 0 9 8 688 646 5 2 2 9 1 1 258 1 9 8 84 2 2 1 0 9 5 4 3 2 1 9 82615441150192 562 552424538249681 48373422 TTG T TCT T T TT G G G T GTT G T G T T TTG TTTTG TTT GTT T T T TTG TAGGCCCAC TTT TCT TATGT T TTAGCGCTAAACCGCT T TGCACCTCTTCTTTACT TT ATGGGCT TCTT TAC ATAACAT TGT T CT TCAG CAGTAG CCC AACAACCAA ACCG A C ATC ACT AC G G C T A ACG T A CTACACACCTGTTAT GAAG GCCTAT CCA ACACTTA AC T T GCACA ACAC ACCTACGTGTGAGGGCGTT TT TCT G T GGCTTCGT G G G TCGGCG T G G TCG GCGG G T GGG GGGG CGC G A GGC TGG GGG G GGGGGGG AGG G CGGG GGG G G GGG GGTGGTGTGG GTGTG GGT CGGGGGGGGGGGGGGG GG G GGGGGGGGGGG GGGGGGTG GC T C TGC CGT C T T TGCGGTG GTT C TGT CGT T TGT T TGT TCTGTCTGCTT GTGTCTG GCTATG GCTCTG GGTTTC GTGTG GCTCTTTTTT GTG G GTT TCTGCTG GTTTTT G GTTG G GGTATTTTTGATGTTCATAAT TCAGAG AT T TAA ATAT T T T T TTAACATAAG A AT T T T TAA ATG ACGTGATTAAT T T T T TAG AAGAG A TAT T TGG ATATTATGAT TGAGGACC A ATC C A C A AACAC CCA CCC A A AAATCCC A ACC CT GAAA C A A A ATCCG GTC CCGCCTGTG CTC CTA CTC G G GCG C C G G C CC CC G G C G G G GGTGTATG GTTG GTGTGTGCTG GCTG GTTG GTTGTGTGGT T TTG G GTGTGTGGT TGTGTGTGTTGTGTGTG CCT TTT T T T T T T T T T T TCT T T T T T TGAGCTG T CAGTATACGCAGG TCGTTG C GTGTATGT GTATGCTACGCCGGGAGT C C C A ATCTTTGAATACCGGT C T G C A C AGCTTTA G A G ACCCTG C C C G G G C G C C G G G A GC T A CCGTTCTTTTTTTCTCTTTTTCTTTTTCCTTTC C CCTTTTTTTC C C C C C C C C C C CCTTTTTTTCTTTTTCTTTTTTTTTTTTTCTT28 0 2 6 7 6 5 5 6 6 8 2 5 5 656 6 6 7 4 5 5 096 6 6 4 9 171 851659210459459682779 8 0 5 0 4 01604673446864486 7 1 744 3 4 8 6 83 0 43974311539792 2 659 7 1 7 0 8 30653015124721377 152627282920313233 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 83 3 3 3 3 3 3 3333333333333334343434343434 4 4 4 5 5 5 5 5 5 5 5 51 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 131313131313131313131313131

[0044] 6875863412294396946767249 1 3 5 5 4 4 3 5 4 7 2 9 1 8 9 5 6 3 7 8 75 0 8 1 4 6 5 1 8 1 624272502477568298312455457503 1 5 5 1 9 4 64 1 3 1 3 7 089 0 4 7 7 3 62 9 5 5 5 9 1 73 3 42 7 1 6 4 6 2 9 6 2 5 1 9 8 6 7 9 4 6 51 1 7906068831047552007440381363 7 3 4 1 7 6 3 6 1 7 6 2 8 8 5 2 59 8 7 6 4 2 2 7 1 0 6 4 4 2 2 1575594715121583543603784049392527030 TTTTCTGT TT T TGTT TGTATCT TG TTCT TGTT TTTTTT T TTTT T TT TCTTTT T TA GTCT T TGTTGTG TTAT TC T TTT TT T GT CT T TCCCGGT A G CTC CCGTTG CCTTCAATA TTCTCGC A A GCGACA GCGCGTTCATTCAA CCAG G C C CCA A AGC CACAT AACCC GTACA ATCAT A CAT AAG C C CCA ACA A AC TC ACACA AACAA A TCACT A ACC CAACAC GAGAGTTGGTGGT GCA GGCGG G G T GCGG GCGGCGCGGTG GCGG G GTT GCG GCGCGTGG G GGG G GG GGGGG G GGGGG G G G GTT G G G GGGGG AGGGGG G GGG G GTG GG GGTGC TG G GGGG GGGGG GG GGG G GGG GGGGGGG GGGG GG GGGG G GG TG G GT T T T T C TGT T TGT TGTGT TGT T T T T T T C TGT T TGGTGT TTT TG G GTTTC AT TTTG GTTCTGCTGTTC G GTTGATG G G G G G GCTCTCTTT TAT TG G GGTCTCTGTTGATG GGTCTG GGT TCTC GTGTGTTTAT T TACA A AT T T T TAT GA A AT TCT TAGGAT AAAGAG ATAGT T TGT TCT T T T T T T T TCT T TCG A G CT T TCG G G A G ACA GCGCGTAAG A AGGA G AGGCATCC ACC GA C A A A C CTA ACC ACCC CATCCC ACC A A C CGATC ATAAC CGT TG C G G GTCCCCTC G GTC G CCCG C C G C GTG CTCCTG C C GTA C CCTGCGTGTGT TTGTGTTGTTGTGTGTGT TGGT T TGT T TGTGTGTGGTGG GT T TGGT TGTC C ACT GTTAT AACTGT T TGTGT TGTGT T T T T T T T TGTGT T TGTGT TAG T AAG C C C T T TCCATAACG CCG GAC C G AGT T GAACCTT GTT A AGT G CGTTT AGTATATGTTTAT T A A AGT GGCT T G A A ACTC TTTTTC C C C C C GCTTTTTTTTTTTTTC C C C C C C C C GT T T T A T TCTTTTTTTTTTTTTTTTTTTCCTCTTCTTCTTCTTCTTATTCTTCTTCTTCTTCTTCTTCTTC21120596 35825 2 218016858534463 39986950625293 8 4 5 9 6 6 5 0 7 04 6 5 695 7 529774 3 4 1 1 7 4 6 2 4 5 02 1 6 2 2563411911454341134768262731434760111242344547695061626364656667 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 23 3 3 3 3 3 3 3636363737373737373737373738 8 8 8 8 8 8 8 8 8 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 131313131313131313131313131

[0045] 71847747 47 192974 49 622 9 9 3 3 2 7 8 1 2 4 619 6 8 3 8 6 5 9 867 8 65 9 4 4 8 4 964090047694765095260846311819456333 6 7 3 99 4 6 2 03 71 8 6 497 5 36 1 0 262 7 81 89 2 9 6 5 0 0 9 9 6 4 9 0 5 7 1 6 2 1 8 32 40206 93 351971 19 794774711 8 9 3 7 4 5 3 359 2 6 6 9 2 1 0 665 6 99 6 6 556 1 145 5 5 48019431000976775240 87073616326959869 8037 CGTTTT T T G T T T T T T G TTTTT G T T TTTT TT TT TT TTTTT T TT CTT TCTTACATAGT TAGTCTATT T TCG TT TTTGT TTAATTGCC CCGC AT TGG ATA ACTACAATCCTACACTGG ATT G CT T TA A A G A GAAGTTCTTAT CTCACAG A CCA TTAG A A CCA A A AT G GCT TTATTCAA A A G A A GCC A TTACACACAT GCACAGCAC A A GAACATCAC A A A ACACACA ACACG G GCGTC C CGGGG G TG G G G GGC T G GTTCGT G G G G G G GCGG G G G GCGGCGGGGGGG G G GGC CGGGG C G GGG G G GGG GGGGG G GGGGG G G G GG GGGGGGG GG G GGGGG GG GGGGGGGGGGGGGG GG GGG GGGGGG GGGCGT T C TG G GT T T TG GT T T TGT TG GTGT TTG GTG GTTGT TTG G G GTGTGT T T T T T TTGTG G G GTG G G GTGTGTGT T T T TGGT T TTGTGTG G G G GC CTC CTT C TTAT TT C C C CTATATT CTATCTC C C C GTC A GTCTATTT TTATAGT T T TAG A AT TTT T TGAC AAGA A A AT TGAAATGAT T T T T T T TGG A A ATA G A AT T TCGAAGCGT T TAA ACAA T T TGTGTGCCATATA G GC ATA A A A ATCCCAC A C A ATCACCC CACACAC A A A ACC A C C A AACA TCTGTG G G GTG C C C GTCTGTG C C CTCTC C C G G GTG C A CTCTG A CCCCCG GT T TGTGTGT TG G GTGTGTGG GTGT TGTGTGTGT TGG GTGTGT T TTGTGTGTGT TG GGG T T C AT T T T TCT A C T TT T T T T T T TGT T TGT T TGT T T T T TGTGTGTGCGG G G CTC GGCCTCTATATCG A T G AGCGACG C T CTGTATACAT GAAACATGT G GGTTACT TGAT G G G G GGTGCATGTG A A TA C C C C G C C C C C C C C G GG G G T C T TT T TATCTC C C C C C C C C C C C C C C CC T TTTTTTTTTTTTTTTTTTTTTTTTT CTT CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT407857313201600601 89618040618744580 3 1 1 046020 8 8 3 1 3 5 8 0 68 1 3 5 2481327645 2 0 0 8 0 1 1 2 5 96 4 4 134677203542116974253565386142354243141246154113949596979899900102 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 63 3 3 3 3 3 3 4 40404040404040404141414141 1 1 1 1 1 2 2 2 2 2 2 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 141414141414141414141414141

[0046] 57900 113 87 29665 674 9 7 8 3627618962996 8 143 9 912492067 6 35 164 784 1 7 76270640385 3 725 4 3 3 8 812556968032464809 7190 028448 8 1 9 5 3 807 3 6 2 643 286 7 0 7 1 026 2 3 7 9 036 55271 1418 3 306472 27498347803433174201 0 9 6 6 746 99689734 2 295 60 9 3 6 1 2 304 8956269544 4 9 0 9 6 1 0 694 13104996556403 23 TT TTTT TCGG T G T TTGCGTTT G TT TT T TTTTT TT TT T T T TGTTT T TTT T TCT TCTT AT T TAT TTTGGT T TGTC GTCTG ATTT TAT TCCGTA AAAA GAGC G CGCGCTGT G T GTATCGT A G G CGT G GGGAGAGTACATTC A CACACA A AG CCACT T A ACA C GAC ATAT ACAC CC C AA A CCA CTAGCAT C A ACA ACA CA GGACAG A GCACA ATCAC CAC A T CCA ACACGGCGGCGGG G GTTTG G G ATAGTGT G G GTGTTT GCT G GCGGCGC G G G G G GGGCGG GGA GG G G G GT G GGCGG GGCGGGGGGGG G G CGG GGG G GGGGGG GGG TTGGTG GGGGGGTGT T TGT TGGCGGTG GTTGGGGGG G GG GGGGGGGGGGG G GGGGGGGGT C TGT CTG G G GTG G GTG GTGTGTG GTG GT TGT TGT TGTGTGTG G G GT T T T T TTG GTG G GTGTGTGT T T TTG GTGTGCTTTT TC CTCTT CTT TTC G CTC TTT G CTTTCTCTC ATTTT C G ATT GTAGTCT T T T T T T T T TCA A G A ATA GAATATGTGTAAT TTT TCA GAA AT TGG AT TGT TGA ATG AT TGATAT T T TCGAAAACGTCT TGGAA AT TGG AAAGATTGCCCCGCCCCCCC C C A A A CCC CCC AGAACA CCA C A C C A A ATAAGCGAGT T TGTGCC CGCGTC GGCGTG GGT TCTC CTC GG G GCGT CG G G CCGT TGT TC GGT CCGTGGTCGTC G G G G G C GGTGTGTGTGT TGT CTGCTGT T T TAT T C C CT T T T T T TGCT TGT TG GTT T T TGT T T T T T T T TGT TGTGTTTTTTATAAATCCG TGGTAGTAC ACATAGGTAAGCCCGTTGT GTTTTC GCTTAT G G G G G CATTGTACGTACGTCGGTCGTCTATATTC C C C C G T C G C C C G T C C GA T T A T TT T T T T TC C C C C C C C C C C C C C C C CTTTTTTTTTTT CTT CTTTTTT C CTTTT CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT0642948462393660822956 01499 705539652 92109865 5 0 05514 8 9 23 0 1 5 8 5 4 282279 7 8 0 7 043 7 0 4 14 1 1 4 2 6 63486823476561167012212115703041324523372543772829203132333435 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 04 4 4 4 4 4 4 4343434343444444444444444444 4 5 5 5 5 5 5 5 5 5 5 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 141414141414141414141414141

[0047] 2487 29 354045865953778 2 7 6 3 6 5 9 8 466 2 3 5 3 2 9 8 6 117 9 5 46 5 2 8 2 5 4 7 5906739034816893049556475899723583 0 6 9 9 66 2 821 4 4 9 0 7 7 8 5 12 2 1 774 7 3 51 8 58 4 3 6 2 4 0 0 0 1 4 6 8 1 8 7 2 5 1 46 7 105229474288792702368934 0 3 1 1 428 0 1 3 8 7 0 6 1 237 1 6 82 039 8 6 6 3 3 3 0 9 7 66323848050299 0806734242226121978 150210 TCTT GTT T T TTT T T T TCT T T TTT TT G TTTTTTG T T G G TCT G G TTTTT TGTTCCCTCTCC AT TG AC CT TGT T TGTGTC CTG CCCACACACGTATG G GATGATTCT T TTTCA CT T TGC CTATTACT GT TG GA CCTC ATCCGATA AGGCTA AC T GTC CAGCAGCAT TCA AC C ACAG GCGGCA AT A CTT A A AGC CAG GCCGTA C ATCGTTCAGCAA A A GCGCC AG C T ACATGTTCAGCCGTT A A CTTTGAG TT AT ACAC TTT GCAT TGCA AGC CGGGC AGG G GG GGG G GGG GGG G G G G G A G G GGCGG G GGC A T CGTGGGG GGG GG GTGCGGTG GGT TGGGGGGG G GGG GGG GGGGGGG GGGGGGGGGGGGG G GGGGGGT T TGT TGTGT TGT CGT C T T T T T T C T T T CGT TGGT TGT TGTGTTGTTT GT TG G GCTTTATT GTGTG G GATTT TG G G G G G GCTTTCT TCT TCTGCTGTTGATGTTG G GCTCTCTTTGCTCTG GCTTTG GTTTTTTATCATCAA CT TGG GT T TTAG G AT T TCT T T TTT TGT T T TAA GCATA ATGTA A A G ACAGAT T T T T T TGG ACAAACA ACAT TAAGGT T T TGG AGG AGCCTCATAACCAAC A ATA A CACTACCCC A A AGA A C CAC C A A ACA AAC AGTGCC GTCAGGTC G A A ATCTC G C C G G G G GTC CCC CCGTG GTG G C GTTGCCTGTGGTGTGT TGTGTG GCGT CGT T TGCGTGCGGTGG GTGT TGTGGCT T TGTT T TGT T TGT T T TGT TGTGT T TGT T T T T T TGT TGT TGT TTGTGACCTTGGGTT GATTCT TGGTCGGTA GACTCG CGGTCT CAATTC G A CTATCTACTC G CGTTGTCTAGT TTG GG C G C C T CGGTGTA A A A GCTC G C C C C C C C C C C C CTTTTTTTTTTTTTTTTTTTTTTTTTTTTC GCTTTC C C CCTTTTTTTCCTCTTATTGGCTTCTCTTGTTTC T A C GTTCCTCTTCTTCTTCTTT43 4 0 1 7 2 1 315 2 289 5 6 4 4 5 5 4 7 7 0 0 4 9 7 6 5 14812791033600624 5 35921 1 7 2 4 5 7 5 3 6 8 6 8 9 9 4 3 9 64157466 7 1 1 2 1 24334763456543392970104764616169767923472612116263646566676869 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 44 4 4 4 4 4 4 4647474747474747474747484848 8 8 8 8 8 8 8 9 9 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 141414141414141414141414141

[0048] 538081 69 405678771 757 8 9 8 4 6 522 5 4 7 6 3 129 8 8 9 7 932 1 2 48 2 2 4 0 3071520259344148987652478497733633363993 0 99 7 2 957 2 3 6 848 05095802 1 8 66 3 93 0 5 0 1 8 5 4 6 0 4 6 9 1 8 4 8 4 5 96 6 9 96 67949916 44 60 29 48300 1 4 655 0 3 0 0 3 280 6 2 4 7 480 6 7 96 6 466 6 5 46456 6069537164 8414312624523 68552594042 670594 TT T T TGT TTTGTT T T T G T T TTGT TT T GTTCT T CTTTTT TGT T T TGT TT GTTTCTTCT TGTAGT TTTT TT GTGTTT TT T TT GT TTT TAG A C C G A C CGTT AGA G TAT AT C TCA C A G T A A C G A A T A C CTT A T A A T GAC G G G C CAA C G C T ACC A T T GAATAGAA AACAA GAT AAAAAACC C T TCA AGC CACACAC CA AGC CCTACACACCGACCTATC CGTT CGCAGC CGCCGTTCAGC CGCGCC AGT CACACGG G G G G G G T G G G C G G TGG G T G G GGG G G G G G G G TGG G G A G AGG GGTGGGG GGGGGGGGG GGGGGGGA GGG GGG GTG GGGGGGGGGG GGGGGGGG G GGGGGGG GGGG G G G G G G GGGGGGGGGT T T T T TGT T C T TGTGCGT TGGT TGC TGT T TGT C T T TGT T C T T TTG GTG G G GTG G GTG G G G GTGTGTGTGTGTGTGTGT TGTGTG GTGTGGTC CTTTTTC ATTTC CTCTCTCT TT ATTTC G GTT A G T A C A C ATC G TTT T T T T T TCTCT T T T A T T T T T T TAGT T T T T T T TATG GT TA A A G AT T TGATAAATACA A A ATATA A A A GGAGAAGGTAT TCAC CAT G GAAA G ATGAGCTCCCC ATAGAGC C CGCAATAACAC ACA A A A C A A C C A A A A ACCCC ATCGT TCTG G G C CTCTC G G C C G A GTG GTCTG GTCTCTGTGTG G G C C GTCTGTTGTGTTGT T TTGTGTGTGTGTTGTGTGCGTGCGTGGCG GTGG G G G GTGTGTGCGTGGTG ACAGCG C T C A GAGT T T T T T T TGT T T T TACAC T C T TCT GAC G ACTCGTGCTGGT T T T T T T T TGG G TGC CAC TGG CA A AGTGTATCTCT G C CCTATTTGT AAT CTTGT G G G G TGTGT AG ATG AC C C C C C C C C G C C C C C G C GT A A T CT T T T T TC A C C C C CT T T TTC C C C C A C C CT T T T TTTTTTTTT CTTTTTTTTTTTTTTTTTTTTT T T TCTTTTTTTTTTTTTTTTTT35330836 5926215 25033930327 85155589948 2018041117 9 011 2 6 4 17 8 7 2 423 4 196422 9 8 713 1 3 8 8 62 2 3 4 4 3537661433416974492671421418604044372865304615969798999001020304 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 84 4 4 4 4 5 5 5 50505050505051515151515151 1 1 1 2 2 2 2 2 2 2 2 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 151515151515151515151515151

[0049] 37967618367922 31 939 2 8 346 6 9 8 8 5 7 1 4 4 9 92482 8 1 5 6 8 1 79 9 4 0 3 8 8 960299833978643003391360572013061950 5 1 5 10 1 0 0 6 4 6 283 8 7 589444 1 4 1 2 12 1 98 0 1 1 6 9 8 7 6 3 1 6 5 3 3 3 4 2 7 40 6 043761112 90 3535560561 89 7 1 4 2 8 1 9 0 0 1 49393 9 8 0 8 5 2 42 0 0 4 3 3 108 5 3 3 38 49278636060665254360947 7 22201998957443 GTTCTTTT TTGTG T TTT G T G TTT T T T G TTTTT TCGTTTTTT TGGTAAT GTC ATTT C GT TCTCT TTT TC TTCT T TTT TA C GTTTGT TGT T T TACCAG AC C ATAG GAG CAACCCC G CAACT GGT G G T GTGC TT AGGAC TCC AC CACT GGG CAG C C T C GAG C T G G A AAAAT CAC TACGTAC CTTCGG CG AC GG C CGTT CTAC CA CGC TACCTATC CAGCACACACTTAC CGCAGCACTTTTTCAGCACACACA GC GGG G T G G G G G G T G G G T G G G GGGGCGGC G GGG TT G GGG CGG CGG GGG G G G CGG GGGGG G C TGGGG G G GGCG G GGGGGG GG GGGGGGGGGGGGGG GGGGGGG GGGG GGG GGGG G GGGT T TGC T TGCGGCGT T T T T C T T TGT T T CGT T T TGT C TGTGTGTGT TTGTGT TGTGT TG G GTG GTGTGTG GTG G G G GTG GTGTGTG GT TG G G GATG C G CTC G TAT TAACT T T T TATTTT TTT TTTTTC CTC GTCTTTCTT CTC C A GT TA GTAT T TCAT TAT T T T T T T T TAT TTTAT TATGTTTTT TAGAC G AAAATGAGA A GGAT GGAG GGATA AAACAAAAAGG A AA AA A A GTGA C A C C A AACTC A C AGC AAA A ATC C C CGC A ACCTCTC A AGCTACAACG CCGTC CTGTGCC C G CTG C GCG G G C CTCTCCC GTG C C C GCG C A G GGTTGGTGTGCGG G GT TGTGGCGTGGT T TGTGG G GTGTGTGTGCGTGT T T TG AC AT T T T TGGG ACGTACCT T T TGTCC C CT T TGTGT T T T T TGACATAGTC TCACC G G TT T T T TGT T TGTGTGT TCT GGC C C TCG G C C T CCATGT G G A TACAC G C G GTC A AGTGTAC GAT AACGTAC TGTGTCTT T AATCGTTTCGT C C ATA C C C A C A C C C C C C GTTC C C C C AC T T T T TTCT T CCTC C C C CT T TTTTTTTTT CTTTTTTTTTTTTTTTTTTTTTTTTT T T T T TCTTTTTTTTTT553708862923 939543245 033 253275000 3465677415901 14 6 4 3 3 1628 3 1 1 0 1166173464 3 4 4 8 5 869 97 4 6 4 6048776615177972273632403465413516176971453014192031323334353637 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 25 5 5 5 5 5 5 5353535454545454545454545455 5 5 5 5 5 5 5 5 5 6 6 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 151515151515151515151515151

[0050] 18554341831220326964219 1 9 5 857 6 3 5 5 5 2 1 7 9 9 1 6 1 1 4 7 86 1 8 1 4 0 4 5 9 0 138349380027138387302304256063 9 5 2 6 1 3 49 5 2 0 6 1 7 8 2 7 9 7 4 55 1 8 8 4 9 5 4 77 7 11 8 9 1 4 1 7 4 8 4 8 9 6 3 9 5 3 8 8 57 7 2429582656270196658321499238 8 2 6 1 8 4 4 5 3 4 2 5 0 3 7 6 51 0 0 6 3 3 2 2 2 9 9 4 3 2 0003 1634201987242058767390494775435190 TTGAT TTGT TT TG ATCT TGGTTTTTTTT TTT T T T TCTCTCT T TCT TT GTTCTCTGTT TC T TTTTGTTCTCTGTG T TA GT TCTAT T TCCGG C C G C ATTCCAC A G CCTTAGGGA GG C AAGTC T G GTCGGA CCCATAAC GCCTACCAGCAC ACACAT T TCC ACAC T G G A C G CCACACACA A ACA AGGCAAAC A GCT C A AT ACACAG AACACAA GAC ACAA T TCCCCTA AGGTCG G G G GTT G G G G GCGCGGCGG GTTTTCGG G G GCGTT GTT G TCGCGG GGG GGG GGG GG GG GGGGCGGG GGGGGG G G G G G G GGGGGGGGG G G GG AGGGGGGA G GGG GG GGGGGGGG G G G A GGG GAGG G GGGGGG GGG GT TGTGT T TGT T T T T T T TGTGT TGT T T C CGT TGT T TGTGC TGT TGTGTGTCTGTCTGCTTTGATGATGGTG GAT TG G GGTCTCTG G G G GTT T TCT TG GATATG GATTT TG GT TTCTGCTG G G GCT TGTT TTTT GTG GATCTCATTATGAT TAATAT T TGT T T T TCTCT TTT TGATG AAG GTA A ATG A ATA AT T T T TCATATA A GT TGACAT TTT T T AGGTG A A A CT T TAAGATAAGATGCCA A AAC CTACACAC AC TAATA C CACTC A A A CCCCCACAC A C AACTGGCGGTGGTA C CGTGT CG C C C GC AGT TGTGTGTC G G A GGT T T T TCGTCGTC C G G G CGC TGTGT TGTC C C C GGTGT TGCGTCGTG CGT TTTT T T T TGT TGATGGACGGCA T CT T T T TGTGTGTGT T T TGAT A TGCACGT T T C G CACT T TGT T T TGT T T T TGTGTGT TGA T G A C TTG A ACC C CA T G A AACAC CTTAC A A ATTTTGTTTGT G TAC AAAGTC G GTT CTGTA ACTA C C C C C G C C C C G TT A TGACG T CTTCTTTTTTTTTTTC C C C C C CCTTTTTTTTTTTTTTTTTTTTTTTCTCCTCTTCTTCTTCTTCTTTTCCTTTCCTGTTCTTCTTT0443 02756218648515164120679 1 45868 549688452 50 541 0 3 4 6 9 96 6 093 79526652 3 474 5 8 5 9 9 3 32 7 363036156011353823311010446565302433356527646346136465666768696071 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 65 5 5 5 5 5 5 5757575757575757575858585858 8 8 8 8 8 9 9 9 9 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 151515151515151515151515151

[0051] 484157 70 205383 96 3 3 9 125 4 3 1 9 168 3 230 2 8 9 9 1 848 2 3 6 6 33 0 2 5 4 0024478045838800639203174340543333497012 9 10 7 2 004 6 9 232 2 10174322 7 3 36 9 07 0 6 8 6 4 3 1 0 7 3 8 7 5 7 5 3 4 3 77 5 2 31 115846 48 63968886 54 9 0 0 4 420 8 428 7 6 4 7 1 221 2 6 6 0 67 7 496 8 877 5 4 47 32229121017 79486 7352674784344 6079478674 GTTTT T T TTGTTCT TTT TT T TT CT TTG GTGCT T T G T T T G TTT TCAC T TCTTCC C T CTC G CG GT T TATC G GT TTT TA GTGTCTATTT T T T T TGT TCTAG TT TT A A CT GAGTT C AAATCC C ATCCTGAAAC GATATGCGTTAA G T GCA AGTCA ACA AC TG AC C C A A TCA ACACA TCATA AGAC GCCTTGTAATCCT G C ATT ACACAT G C CGA CCCCA TATTACA A C A T ACAAGCGCGG TGGC GT CGG G GTTGG T T G TTT G G G T GCGCGTTCGTT GCGGGGGG G GGG GTT G G G GGCCT GGAGGGGGCGC G G GGCGG G G T G T GGGGGGG GGG GGGGGGGG G GGGGGGGGG G G G GGGG GGG GGGG G GGG GGGTGTGT TGT T CGT TGTGT T T T CGT T TTG G G G GT TG GTG G G G GTG G GTGT T C TGT T T C TGTGTGTGT TGTGT TGTTGTG G GTGTGTG G G GTG G GTGCTGT TTTT G CT TT TTCT TATC GTATA A A G CTCTC T G CTTT TAT TC CTTATCT T T TAT TCAG A ACATGGAAAT T T T T TCT T TGA A A ATGAA ATTA AACAT TGGAAT T T T TGA A GTG ATTTCT TCT T TCTCAGG A ACA A ACACCCCA AAA A C ACCTAAC A A CGAA C A A AAAAC AAA C CTCCC CTAAC AGCCA G C C C A G C G C G G G C A C C C C GCTC CTA GT CG GT TGT TGTGCC CTA CGTGTGT TG GT TGT TGGTGGC TGG GTGCGT TGGTGTGT TGGT CGTGTTCTGT TGTGT TACCT G TCT GTGT TGT T T T TGGTT T TGC TAC TAG A G T A GT T TGT T TGT T TGT T TGT T TGTGG CCACTTC A C GTG G TACGT TAG CA ATTGT GTC G GGT CTT GGTCAGTT CAGAC G T TGCGACT GGTCCAAG CG C C C C C G C C TTG C G G GT GGTCT TT TG C C C CTT CT TCTTC C C C C C C C CCTTTTTTTTTT CTTTTTTTTTTTTTT CTTTT C CTCTCTTTTTTTCTTTTTTTCTTTCTTTT08027400 5566159 049 9 811517080579604 38848002917597 335 3 6 9 96 8 1 2 312 13696601 7 976 3 5 9 9 56 3 1 4 2771656247386376356878767332343762453764466045379899900102030405 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 05 5 5 6 6 6 6 6060606060616161616161616161 1 2 2 2 2 2 2 2 2 2 2 31 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 161616161616161616161616161

[0052] 988519348894066242598119 9 3 9 9 8 1 6 6 6 7 8 9 3 5 4 9 868 2 9 6 8153934718786807917349582636054354732602631199869210215596569 7 1 0 478 0 3 54 7 64 7 0 4 1 2 4 1 1 2 0 2 7 4 5 1 2 0 3 83 8 16625001950128618472058862 5 6 8 9 4 4 0 3 4 6 8 4 185 7 0 0 12 2 2 0 0 0 9 8 6 5 4 9 9 8 776165515428020767391218070679 54835333 GTGTT TTTTTGT T TATT TTT CTT GT TG T T T G T T TCT TGT TTT TAT TTCTT TTTTTTCTG T TTT T TA G TTTT T TCTCTTATCTGT TATGAATTGATT C CC CGGACCCTCCGTCGTTTAC G CGCCACAA A GACAGTTTTTCTGTTAT G T GTACACACA ACA GTAG G A G G G C TCT ACACACC ACA AG T GCACA AGCACCAG T GCCC A AC CCT AG GCAGAA A TCACA C ACACCTCGCGTT G G G GTT GTT G G GTT GCGG GCGG G GTTCGGTT G G GC TGG A G G GT G GGGGC G CGG G G C G G GGG G GGGGGGTGG GGCGGGGG G G G G GGCGG G GGGGG GGGGGGGGGGGGGGGGGGGGGG G G GGG G GG G G G GGGGGCGGTGT T T TGTGT T C T T T T TGT T TGT T T T TGT T T TGTGTGTGT T TT TG G GTGT TGTG GTG G GTGTG G GTG G GTGTGTGTG GTGTGTG G G G G GC CTTTT CTC A G CTT TTGTC C CTCTC GTCTA G C TTC C C GTCTTT T TTTTATAT T T T TGTGT T TAT T T T T T T TGT TGT TATAT T T T T TCTCT TGTA GGTATGAAC G GA AC AG ACGCAAATG G ATGAGA GA G AAGAG G A A ACGA A C C C A A AAC C ACAC C A ATAGA ATC CCC A ACCGC C ACCACTATC AGGTGCCTCCCTG G GTCTCTG G CTCTG G A G G C CTC G G C C CTG C C A C ACCG G G G GT TGG G GCGTG GTGT T T TGTGTGTGTGTGTGGT TGTGT T TGTT T T T TGT T TGT TG G G GT TG G GTGA GT T T T T T T T T T T T T T TCT T T T T TG GG CAG C GTGTCCAGTAT G G T TAC T CCT GGG TACCC CA CT CCG C C G CA TGT TGTAT A G G A TTTGTGTGC AACAC GAC AAC G TAAG GAAGT T A G TA G C G C C C C C G C C C T C G GA T CTT TT T TATC C C C C C CT T TTC CC T TTC C C CC T T T TTC CC TTT CTTTTTTTTTTTTTTTTTTTT CTTTTTTTTTTT T T T T T T T TCTTTT57954083304200251750360067710654211471970450 20 902 635 0 8 4 48 9 3 8 3 3 5 9 4 55 8 307 7 422 2 8 8 1 87 7 4 6 4 4 2 3 633970124348762615161331387824672620156241113233343536373839 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 46 6 6 6 6 6 6 6364646464646464646464656565 5 5 5 5 5 5 5 6 6 6 6 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 161616161616161616161616161

[0053] 599223832622513787465 6 4 1 1 6 5 7 7 1 3 7 9 2 748373912117853965864536657442781 556 644 3 4 4 63859473 6 38 51 12870345472 2 7 4 0 5 6 4 2 6 5 9 5 5 1 4 9 2 1 89197 1 1387022 13 82 2976221100182944869786576503555691 6 1 9 0 3 5 3 6 8 2347362113087574453711827 5254 1 5 1 1 4 515 047331293564 3 074 03 10414 TTTTT TT CG G TT TGT T T T TTT TT TT G TTTT TG T TTT TTT TTACTCGTTTGTG GAT TTCT TGA C GT TCTG A TCTATC TTTT T TTT TA AT T TTT TT GTCTAAC C GT T C G ACT CC TAACCTC GT G CAACGCTAG A AGT GCAAGCAG ACACA ACATGCG TA TA CTC AC CC AA G A ACACACA ATCACAC TAG TCC AT G ACA ACAGCAA C T C G A C A ACTTT ACA ACACACA TTGG G G GTT TTT G GGGGGGG GGG AGA G G TT G G GCGG G GCGTT GCGG G G TGC GCGG G GCGTCGGC GGG G G GGGGGGG T G G G GGGGG A G G G GGG GGGTGTGGTG GGTG GGCG GTGGTG GGTGGGGGGTGTGG GTG GGGG GGG GTGGTGGGGGG GTG G GGTGGGGCGTGTTGTG GT TTG GTG GTGT T TTG GTTG G G GTGTGT T TTG GT T C C T T T TGTG G G GTGTGTG GTG G GTGTGTCTGAATTTTGTC CTTTTCTCT TT TTTGTTTC CTGTAT TT ATTTT TTTC TTTTCTTTTCT TTTA CTGTC CTGAA TGTGT T TA GT T TA AT TAT TAGCGAG CAA AGAAAAGAAG ATAGGGG ATAGA AC T GAGAAAAA AC AG AGA GATGAGGA CAC C A A AGC AAC AAC AGA ACC C CTA C A A C C CTC A AACCA AGT TG CTC CCG G GTC GTC G C GTG G C CTCTA CTGTGTC C CTC G GTC A GCTGGTGTTGTGCTG GCGTGGTGGTGTGTGT TGTG GTG G GCGCGGTGTGTGTGCC T TT T T T TCT T T TGT TGT TGT TATGT T TGT T T T TGT T TGT TATACTGTACTGT CGATATATCTAAGTGAG C C TCGTATACCTAAC AGTTCAACTGAACT CGTTGAGA T TGAAGAAGGAC T CGACACATATA GGTCTTCTTC C TTTTTTTA GCTTTC C CCTTTTTC C C C C C C C CCTTTTTTTTTTTTTTTTTC C C C C TG A TCTTTTTTTTTTTCCTCTTCTTCTTCTTCTTCTTGTTC664 7 7 8 1 5 5 9 9 0 9 7 0 514 2 9 045 7 4 0 8 456 586 0 4414247404388686170 9 8 4 4 955 6 1 9 281 9 5 1 8 4 319 2 445 6 5 13 4 3 3 1 6 6 7 231561454417301735376015321917616614182447756667686960717273 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 86 6 6 6 6 6 6 6767676767676768686868686868 8 8 8 9 9 9 9 9 9 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 161616161616161616161616161

[0054] 71922285 866 158679354 7 199257367 3 688 3 2 3 1 9 2 2 134791671403767367059 5 203 1 337420243 9 6084 474 372148 9450699 426 3 6 1 5 8 442 6 2 7 5 9 4 6 4 5 760 2 8 9 94 37 9 07 400472 29509074 641 53211291001956582573 2 1 5 2 0 0 5 5 0 3 892 58775717551522798720 9 3 8 8 089 89697573 2 0 009 9047 6 2 3 538 025616 17 TTT TTT TTT G TT TG T G TTT TTT TTT TT G TTT T TT T TTTTCT TTAGAATT CAGCTTCT TC CTATCT TT CTCTTT TC CT TGTA T T C TTC TT TATCTCCGTGG G C CGAG GGGA GGT GCC G C A CGA CTACGAGGAAACAA GAGAAGCAC CAC CAC GCT CAAGCAGCTA G T ATACC ACAC A TACA ACAC A TCATCAC A G ACA A AACACAC C CACAACCAC CTGAGACACGGGGG GGGG GGG GGTTCGG G T GTT G GGAG GTT G G G G G G GGG GG GGGGC GCGGG GA G GGGGGGG G G GGT GGG T GGGGG G G GGGGGGGGA G GGGG GTGGTGTGGTG GTTGGGGG G GGGGGGGGGGGGGGGG GGGGGGGG G G G GG GGGGGT TGT T T TGT T T T T T T T TGT T T T T TGT TGTGT TGT TG TGCTGTGTG CTGAT TGGTG G GCT TGT TG G G GATT G C ATTTTTTTG GTTCTGCTGGTTTGCTG G G GGT T TGCTTTA G GTGTGGTG G GTGTTTCTT GAT T TATG ACC CGT TAG GT T T T TGAGA A ATAT T T TAT T A T TTGAA GG ATAT GA AAC AAGT T T T T TAGGA A GTGGGT TAGAGT T T T TAG A A A GGCCTCAGATGA A ACC A A A AAC C A AGA AAA A A ATAGC C A A A AACCCTCCA AGT T TG G G C A G GTG CTCTGTGTG G G G GTG G C CTG GTG GTC C C G GTTGTTGTGT TTGTGTTGTTGTTGTTGTGCTG G G G GC TGT TGGT T TGTGTGTGT TGTGAT TCA T CCC C TCC AT T T T TGT TGT T TGTGTGT TGT TGT T TGT TGT TGCCG G TGAAC T T C CGT T T AAT CAC AATAC A C AACT GAATT GGTGT GAAG AGTGT G GT GAATAC GAACAAAGAAGG A A C GC C C C C C C C C C A C G CTCT G G C A T CT TATC T C CT T TTC C C C C C C C C C C C C CT TTTTTTTTTTTTTTTTTTT CTTTTTTTTT T TCTTTTTTTTTTTTTTTTTTTTTTTTTTTT13888 70250 406514 5 0 6 3 154 1 1 8 4 1 20 0 1 5 12530201 113 84 261 576 0 1 0 0922197348621 7 133 0 2 0 4 1434 1 2 5 5 5743447731726382 9 57 825533817 120 6 361233239900102030405060708 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 26 7 7 7 7 7 7 7 70707171717171717171717172 2 2 2 2 2 2 2 2 2 3 3 31 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 171717171717171717171717171

[0055] 93596758836761328910905 3 3 3 9 1 7 1 5 5 6 1 8 6 8 8 8 4 288 5 5 27 1 2 4 9 2 5 0 2 1 210383105592074938412432713569 8 7 4 2 2 4 24 7 5 1 3 9 7 2 7 1 2 9 59 9 6 0 001 8 1 25 6 62 0 2 5 7 8 3 2 6 2 0 5 9 3 8 7 2 4 9 82 1 97582470593350550636081966 4 8 3 0 0 4 8 5 2 1 3 5 1 061 1 8 28 7 5 5 3 6 6 5 8 3 3 2 0 9 74545937369392823525271518875451 113026 TTT T T T T G TC T TT TTGTG T TTT TTT GTT TTT TTGTT T T T GGT T TCG TTCATAGCTCCTCGTAC GATG ATA TTGT TTTAT TGTTA G C ACT TT G GAAC CTGTGTT TT TTT TGTTAA A G A C CCCTC TC CGTGTTAAAAG ACC G CC AGAC A GAGAGAGTAAC CAC CAA GCC CCC G GA AC C C C TCA A G AGC CAC TACTC C C CTTT T AC CAC CACTCT A ACA ACCT CA A C ACTTGGCGGCCGGG TGCGTGT GGGGGGGGTT TTTTTCG GGG GGGTTT CAT G GCGG GGTCGGC CGGGC G TGTGG GGCG G G G GGGGGG A G GG GG G CGGG G GTGGTGTGGTGGTG GGT CGGG GGGG GGGGGGGGGGG GGG G GGG GGG GG G G GGGTGTGT T T T T C T C T T T TGT CGTGT TGT T T TGGTGTGT T CGT GTTG GTT TG GTG G GCTTTA CTTT TGATGGTGATGCTG GATTTG GCTTTG GGTCTG G G G GGTTTCT TCTG GCT TGATTTGGTGTG GTATTTGAGTCT T T T TCA A A ATAT TAT AGCGGAAA AT T TGGCACATGAT T T T T T T TCT T TCT T TAACA ATGACGAATG ATA A G ACA AAG TT A T T TGA C A G AGGCCC C ATC A AAC A A C A A C C A A AGA AACCCCC AC GA A AC TCACCC ATC C CGT TG C GTG C GTA CTG GCCTCTA G A G A C C C ACC G GTGATA C C C GTTGTATGTGT TTGTGTGT TTG GTGGTGG G GTGTGTGT TGTGC TGTGT TG GT T CGTGGC TTGT T T T T T TTT T T TGT T TGT T TGTGT T TGTGT TGT TAAT C C ACAGTG ATAAGC C CGGTCTACGCG CGAACCGCGCTGGCTCC A C G CGGACATAGTAT C G A C ACTTAAGTTTT GG C CAA T CGGTAACGTC CGT C C G C C C C C G G A CC A T G T ATTTTTTTTTTTTCTTTC CCTTTTTTTTTCTCTC C C C C C C C C G C C C T C GCTTTTTTTTTTTCTCTTTTTTTTTTTTTTTTTTTTTT2782 158672531 644 3 40026717639 3972329013825473 2 0 5 2 342 3 11 8 341 03557131 1 5 2 6 3 912 3 7 03 2 634127776126746464373712456568224322287020146826733435363738393041 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 67 7 7 7 7 7 7 7474747474747474747575757575 5 5 5 5 5 6 6 6 6 6 6 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 171717171717171717171717171

[0056] 75 1285159 1635864 910250540460 _ _LL_77L_67 6_ L7_6FF_5 65C5 _55_ C_55K_ M545 N 45 _K_45 _45A3 _ AF353 5 _F_5 _35G_ G2G 2_G52 5__2I50_IV50_I50 5_0_5 5D_ D _9E4994E9_4 _ 4H_ _7Y47W7C7_4F_4_4_6L6F6L4 4 464GTG G GCT TaC CTaa aCaaataat aattt atattca aac cacca acc cacgc ccg gcct c cgcccc ctct ctct 8ccc9cct tccacctccaactaag at t aagg gtgag gaa agaaa aga aaaag gct a agc ctct acac ctcTa aTT TaTTG TAT TGTAT GTAAA AAA ACC AAGT CTGTTGTAGGGGG GGTG G GGTTGTTTGTG TTTGTCAT TCAAAGTTAGA AGATG GGTTGTGGTTT TGAC GTCCACTG GTTCTTTC CCTTTC841 0 847 3 219714677687696071717171

[0057] dareiteoCddetoarCFgscgnol_oneif80oneeB732623692 3 6 2 8 1 612 6 9 3 4 3 636 9 9 9 9 2 3e989 8 340215233766479950797024156863225995569v304818158696401611450 1415897055 5 7 267 9 9 3 4 291467740706668 6 8 7 4 2 169 4 5026674 65 5349325245225635391607959 81 285747961473 31 4 9 1.3 2 5ag4 2 2 2 2 2 2 2 2 1 1.1. 3 241 1 0e.4.4.4.4.4.4.4.4.4.4.4 4.1 1 1 1 14.4.4.4.4.4 4 1.1 1 1 14.4.4.4.4 ffer1Fhtmul TCC G CT TCCCG C T T GACCCACGA ACGAG T T GAT ACC CTCen TAnotit gcAAAC G TACGAGACT C T C TCA G AA CTCT CAA AGT GAAini niCA A A ACA A A AGCGCGCGGCGC C CAGCAGCAGCAGCA A AGAA A AGC C CA A A ACAGCGC C CGGC CGCGGCCiFf sodr tu G G G G GG GGG G G G G GGG GGGG GGGGGG GGGG G GGG ged p ooLsagc onc tGeGG G GTGTGTGTGG G G GTGTGTGTGGTGTGGTGGTGG GTGTGGTGG G G GTG G GG G G GGGTGT TGTGTGT TGTniadods GeecTG G G GTTTTTCTCTG G G GGTTTTTCTG GCTGTGGTGCTG G GTGG G GCTCTCTCT T TCTG G G GGT TTTATGGTuAT T T TGACA ATGT T T T T AGGCG ATGCG CT T T T TTTCT T TCT T T TCTGAGAGA GCA G A G GGG G GTGGAmietde dq A ACA A A AAst cnn sA A AAC A A AGA AAAAAGACA ACCAA A ATAe nesGo di TGGTAGTGGTGGTGGTG GGT TGGTCGTG G G G G G G G A G C G G G AGTGTGTGT TGTGT T TGTGTGTGTGTGTEauit cT T T T T TGT T T TG G G G; tq u aG GT T T T T T T T T T T T T T Ty ueistio G GGGGGGGGGCAGGGGGGGGGGGGC G G T T G G G G G G Gtlmts na lA iT T T T T T T T T T T T TATGTGTATATGTGTGTGTGTGTGTnaNbouDusmCaTCTTCTTCTTCTTCTTCTTCTTCTTCTTC C C C C C C C C C C C C C CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTg doivhi D 5tdI- 51193010285093135135 5 3 5 6 1 6 0 8 3 5 5 3 1 6 1 7 149031137141419321412493529113912 9 1rnin4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4141424o8h or0cgBaeeD.r3of 172773774775776777778 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5777778787878787878787878797979797979el stDI 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 171bnau QoE OTS N

[0058] 2554328089249 7 3 9 2 4 558 2 3 5 5 6 583 6 4 5 5 9 147 2 8 9 8 4 44 8 5 0 1260347954296230671259632731 6 0 4 3 5 9 8 9 9 0 13 0 7 0 1 7 498 4 6 5 4 1 013 3 7 9 7 1 33 303354345590 81 385869484581 TTT T T G T T T T G T TTT T T T TT T TT GTG T T TTT T TT TTCT TCT TCTTT TTTTT TT CTTT TCT TC G A GT TCT T T TCT T TT GTAACGTAG GTAC GCA A CGAACGA T C CCGAAA ATATCGCGGTGA ACAAA T A A A A G TCA A TCA ACA CTA A A ACC A AG C A T C G G A ACCA A A A AA AACACACACA C AC G AGT C T AAC CCT A ACA ACA A A AAACAAAGCGCTC C CGGTTCGGC CGCGCGG G GC TGTTCGGCGC CGCGCGCGGGGGGCGGGGG G A G GGGG GGGG G G GGGTT G C G GGGGGGGG GGGGG G G GTG GTG GGCGGGGGG G G GTGTGCGTGG G G G G G G G G G GTG G G G G GTGTGTG G GGTGG GGGGGCG GTG GG G G GGTG G G GGTGGGGTGGTGTGTG G G G GT TGTGT TGG G GT CGG GTGGTGT TGTGTGTTAT TGT TCTGT T T T T TGT T TGT T T T TGT T T T T TGT TGT TGT T TGTAC CCTATTGT TCATT TAT TG TAT TA CAT TC T G T C G G C C A TGT TAA TGTGTGT TAT T TCGTT TATATC TAT TC A T GGTAT T TC TGT TC T AAG GAAAGT AGT GGAACC G T GGAAG AAG G A GAG TAGAGGTAAAA AGA AGC A A A AGA A A A C C A A C AAA A A CCA AAA A A ACA A ATATGTGTGCCTG GTAT TATGTG GTCTC G G C G G G GTG G G G G G G G G GG G GTG GTG G G G GTG GTGTGT TGTGT C TGGTGTGT TGTGT T TGT TTGTGTGGT TGTGGT TGTGTGTGTGGT TGTGTGTGGT TGTG GGT TTTGTGTGTGT T TGTGT TGTGTG G GCT GCGC C TA GG T G G C C G G TT T T T TGTATGTGT TGTGTATGTGTG G A G G TTGTG G T G G A A G G AC C C C G C C C C C C C C C CTCTCTCTCTCTC CTC GTCTCTCT T T T T T TT T TTTTTCTTTTTTTTTCTTTT T T T T T T T T TTC TTC C C C C C CT TT T T T T T T T T TCTTTTTTTTTTTTTTTTTTTT13691813555719041465159902351910627300655 6 1 3 7 7 1 4 1 0 3 6 8 12 0 1 0 9 2 3 1 2 9 2 1 4 1 2 3 1 4 3 1707991185141209180933 8 2 34 4 4 1 7 4 4 4 4 7 4 4 4 4 4 4 4 4 4 4 1 7 4 6 4 4 1 4 4 4341414346979899900102030405060708090011 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 97 7 7 7 8 8 8 8 8 8 8 8 8 8 81818181818181818182 2 2 2 2 2 2 2 2 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 181818181818181818181

[0059] 84443085196054202 7 5 3 8 2 7 8 2 9 9 3 8 2 9 6 3 8 729 4 3 7 6 6 14 1 7 5 0 6 5 4042174868659128749171 7 9 9 9 7 9 5 7 8 6 3 8 0 84 4 1 1 4 4 4 1 9 5 5 1 8 0 2 8 2 8823331466775717705 49 538602628301 TTT TCT TTTT T TT T T C T TTCTTGT TT T T T T T T T TTT TTTGCTACGGTAATGGTACAGACAGAGTC ATGTTG GCCTC CAGT TT CTTT TGC CTGTTCCT T T T TACCTGA ACC GTACTAATTTCGCAA TCA AC A G T G A GGC CACA A ACACACA CG GC AACAACA CT C ACC ACAA GCC AAGT A G A A TCC ATA C T G GCACA A A A A A A A A ACA A AACAGG GGG GGC CGGGGGGGGGGGG CGTT GGGCGGTGT GGGTGTCGGGC CGGGGC CGGGGC CGGGGC C CGG GGGGGCGGCGG GCG GGGGG GTG GG G G G G G GGGT TGTG G GTGTGTGT G G GCG GTGG G G GTG G GTGG GTGCGG G G G G G GGGG G G G G GTGTG G G GTG G G G G GTG G GGTGTGATGTGTTGTTGTGTGTGTGT TGG GT TG G G G GTT T TGTGT T T T T TGTTGTTGTGT TTGTGT T TTGTGTGTGTTGTTGTGTTGTCATGTC GTGA GTT C C TATAT TATA GAACTT CGT TGATC T A AGT T TATC GATATG C A A A T C C C T A TGACT T T T T TAT T T TGTAATAATCTGACGCG C CAAC G C AAA AACAC G C C CAAATACG GACA ATAAC A G G GTCA ATG GAAA A A A ACC A A CAA A A CCA A C A CGA C ACC A A A A A A AGTGT TGTG GGT TGGTGGTGGTC GGT TGGTCGTG GGC TGGTGTG A C A C G C A C A G A G G G GGTGTGTGTGTGT TGTGT TGT TGTGT T TTTGT T TGT T T T TGT T T TGT T T T T T T TGT TGT TGT T TGTGTGTAGGCAGGGGC G G G G TAG G GTC G G GGG G G G GTT G G CGG C G G C G CT T T T TATGTGTGTGT TGTGTGTTTGTGTG G G G G A G G G A G G A G AC C C C C C C C C C C C C C T CTC GTCTCTCTCTCTCTCTCCCT T T T T T TT T TTTTTTTTTTTTTTTTTCTT T TTC T TTC C C C C C CT TT T T TCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT18171239413899341138635458675968056173531 5 0 1 6 1 2 6 7 3 9 7 0 63 2 4 0 2 3 0 1 1 1 8 1 1 2 6 0 1 8 1 2621262341302131283525 9 6 34 4 4 4 4 4 4 4 4 4 6 4 4 4 7 4 4 6 4 4 4 4 4 4 4 4 3 4 4 4143414440313233343536373839304142434445 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 38 8 8 8 8 8 8 8 8 8 8 8 8 8 84848484848585858585 5 5 5 5 5 6 6 6 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 181818181818181818181

[0060] 28 62766374572956 7 3 8 1 545 8 7 9 1 8 2 8 7 766 1 7 7 2 4 7 9 2 9 24 6302765258999296318939479389933 08 61256803724487872 9 3 2 2 2 2 4 8 6 9 2 79916589 03 74151264704900539048 TT G T T TTT G T TTT T G T T T G TTG T TTT T T T GTT T TTTCTCCTGGAT TTA GAGT T TCCTC CTCA CT TGGTCT T T TTG TCCCTT TAG TCGT TAC A CTTCT T TGTCCATTGA TT T TG AG CAG ATA CACAT GCC C A AGA GCCAA TGCTTA A ACA T A A AA GCCA AACGAGAAAAC T GG AC A C C C C A AAC C C GCT A AAC A ACA A A ACC ACA A A ATCACGGGGTC CAG GGGC TGGGTCGGCGC CGGGGGGT C CGTCGGGGGTGTCAGCGGT CGT G GCGGC CGGGGGGTGTAGC C CGG GGG GGGGGGG GGGG G G G G GGGGGG G G G G G G G GGGGGG G G G G G GGGG G GGGTGGT TG G GTG GCG GTG G G G G GTGTG G G G GTG G G GTGCGTG G GTGTTGCTGT TTGTGTGTGT TTG T GTTGTTTTGCTTTTTGTCT TGC GTGTTGT TTGTGTGTGTTGTTGT TTGTG GTTGTTGTTGTGTGTGT T T TGGTGTGTGTAT C T T C TTC A A ATT CTC T T T C AT TC C G GTAGTAT TGG ATGTAT TCT T TAT TGTAT T T TGTATATATATAAT T AGACAG GAGA AA A TGAGGTAGATAT GG AC GGCG ATAA T G G A A GA ATCT A CTG GA C A A A AACG CC A A A AGAAA A A CGA CCAA A A A A A ATC A C ATGTG G ATC GTATATG G G GTG CTG C G G G G G G G G C A C GATGGTTG GTG GT CGGTG G GT T TGCGT CGT TGTGT T TGTGTGT TGTGGTGGT TGGC GT T TGT T TGT T T TGTG GT TGT TGTGT TGTGT T T TGT T T T TTTTGT G G T CTATGTGTATAG T G G G CTTGTATGTGTG TC T G T GTC CTTT A G ATG T AT G G CTT G G TCAGGGGGGCAGGGGAAGGC C G C C C C C C C C CTC GTCTCTC CTCTC GTCTCTCA T T TTT T T T G TTTTTTCTTTTTTTTTCTTTTTTTTTTTCTTTTTTTCTTTTTTTTTTTCTTCTTCTTTTCCTCTTCTTCTTCTTCTTT0816752937637257046116017169060813375 3 537 4 2 6 4 4 1 3 6 3051 0 9 3 2 1 4 9 2 5 1 2 2 6 0 3 1 9136038 79 81905783515 5 1 0 928 14 1 7 4 4 4 4 7 4 4 4 4 4 7 1 4 4 7 4 1 6 4 4 1 4 49714542424144656667686960717273747576777879 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 78 8 8 8 8 8 8 8 8 8 8 8 8 8 87888888888888888888 8 9 9 9 9 9 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 181818181818181818181

[0061] 9528 8742 398538332 6 5 2 5 5 4 5 9 996 2 4 4 8 8 5 5 1 4 3 6 4 4 1 76 8 7 2 9 647768121711 20706607637 0951241 7 9 7 8 8 7 5 5 20 7 25729 6 7 1 9 3 6 6 748 1 1 0 7 28017 3 1 687624776870084914400 TTG TTT T TT T TGTAT TATTCGT T TT T T TC G CT T T T TT T T TGTG G T G T T T TGT TTTCT T T T TTT TATGTAGTTTTGTGTGTCT AGG T AAC A T A TAAC G GTCC AAT C CC GACGCGAAAC A AA T C CCTCATGCCC GAAA C C A CCAGT CACA A ACATA A CC GGA C C T G GCTC AAA A A ACA A A AGTCCAAATCAA A C CCA ACACA C GCACTTAGTGTGCGTCAG GGGGC CGGGGGGCGGTGC C C CGC CGTGG GGGGGGGGGC C T TGG TC TT GCGGGTC CGGA GG GGG GT C TG GT G TTATTCTAG GGTGG G G G G G GGGGGCG GTG G G GTG G G GTGGGGGGGG GGGG G G G G G G G GGGG G GG GTG G G G GCGTG GTGTG GTG GT GGG G G GGG GTGCTGTTTGTGTTGTTGTTGTGTTGCTG GT TGTGT TGTTGTGT TGTGT TG GTG GTGTGGC T CGG GTC TT TGTGT T TT GT T TGT T T TG GT T TATT A C C C G CTCAT TATA GAT TATGT T A TCTTATCTTT TC C C A CGT T TC CAT T TAAT TG T G G GTATCTC T CGT T T ACT T TATTATAAGAAATCCAGAATAGATGAAACT GA AC ACCTA AAGATAGGAGATAAGAACACCGAG GA G GCGA AG G GTG CTGTG ATG GTCTC G C G G G GTG G G G CAGACG GCGTG CACGAGAGAGACGCTCA A A AGG GTGGTTG G GTGGTGG GT TGT T T TGGT TGT TG GTGT T T T TGTGT CGGTGGTGCT T T T T T TGT TGTGTGT TGT TGTGT T TGTGTG GTGT T TGT T TTAG G C G C G G T G T TTT C G C G C C G GTGT GTGC T C C G TTTT CTG CACTGTGTGCTACTGCTACTG G TCTCTCTG A A T A G T G T A GGTCTCTCTCTCACTCTCTCT TATTGT TA T T A GGT T T T T TTGT TGGT TGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTCTCCTTTCCTCTTCTTCTTCTTTTCCTTTACTTTC001647798821390360551711237353233798020 0 3 5 5 6 8 6 3 3 617 0 02 9 2 0 3 2 3 1 3 5 1 5 3 0 3 2 0 0 02308593018242070737 569 9 4 64 7 4 4 4 4 4 4 4 6 4 4 4 1 4 3 1 4 1 4 6 7 1 6 4 1 1 414566797978999001020304050607080900111213 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 18 8 9 9 9 9 9 9 9 9 9 9 9 9 91919191919191929292 2 2 2 2 2 2 2 3 31 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 191919191919191919191

[0062] 54 853 584 3639958 8 55 531 9832814 25844 8768514 4 5896080 567 822 939 8 3 6 8 1 6 4 8 989083 191129742550 1 3 1 00 268 2 4 784 954 1 1329694 0 553 9 96165 7 7 559 6 8 0 05411638260 TT G T TTG T T T T T T T TTGT C TT TTG T G T TTT TTG T T T TGT TATT TGTGACT TCTGTAATATT T T T TTT TG GT T TAT TCTACTACC GGC G C ATT AGT T T TTC C CTTT AGTCGT T TAG GCCT TCCAGTA CA G G TAAC C C TGT A A T CC AAG AG A ACGGCAAC C T ATGC T C ACA C ACC A A A A A A ATCA ACT AC TTCAA ACTTA T A A ACA A T A ACA AGC TGG TCGTGG AGGGTC CGGGGCGGC C CGGGGGGGGC C TGGGG TTGT C CGT G TC TCG GGG GG TC CGG G GCGGCGGTGTCCGGGC CGG GGGG G G GGG G G G G G G G GGGG G GGG G GGGG GGGGGG G G G G GGGGTG GCGTGCG G G G G G GTG G G GTGGGG GT CG GCG G GTG G GCG GTG GGT TGGTTGTTTG GCT TGT TAGTGTGTTGT T TTGTC G T CTGTTGCTGT T CCTGTTG GTGTTGT TTG GTGTGT TGGT TTG GTTGT TGTTGTGTTGTGT TTGTGTTTTC C C TTT GTAT TC A G T GTT C TTC T C TGT TAA ATGTAT T T T T TAT T T TGTTT TA G AT TAT TGTATAAT TAT TAAAGACACAAGATG GCGATACACGAGCA AGGACAG A GAGG GC G C AAC GACTG CCG GTC ATCCAGAAA AAC A CCC A A CTC C A ATA CTCCAA A A A C AGAATG G C GTC C G G CTC CTGTGTA C C G G G A G C G G GGTTG GTG GT TGTGT TGTGT T TGTG G GT CGT T TGTGTGCGTGTGT TGGT TGGT GT T TGTGT T TGTGT T TGTGTGT TGT T TGT TG GT T T T T TGTTTTGC G GTTTGTGC T G C C C G C C C C GTT G G G T CT TTTTATGTA A A G G T TTA GTT G G GTA AC T G C G CTT T G A G AG TTTG ATTGGC C C C C G C C CTCTCTCTCCCTCTC CTCTCTC CTC AT T T C TGT G T TT T T T T T T T T T T T T T TAT T T T T T T T TCTCTCTCTCT TCTCTCTCT T C T T C T T T T T T T T T T T C T T T C T C T T T T T C T T TTT0963713248603933911263154425553943103 7 8 0 0 7 6 3 4 5 8 7 256 01 0 8 0 1 8 1 4 2 3 3 5 1 3 1 6 4 85172815944389110311 0 7 755 2 94 1 6 1 4 6 1 4 4 4 4 4 4 3 1 7 4 6 1 4 4 7 4 6 1 1 451249724010423334353637383930414243444546 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 59 9 9 9 9 9 9 9 9 9 9 9 9 9494949495959595959595 5 5 5 6 6 6 6 6 61 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 191919191919191919191

[0063] 634716952 2 3 3 4 9 6 6 851 6 8 41462 469 4 1 2 9 6 1 3 458 6 8 5 29 8 1 06979380323304786820288065670184 2 7 6 1 6 2 5 1 38 6 9 6 8 9 6 4 6 3 5 0 9 254 1 8 71437 284 5501461541243 03 28010477 GT TTTT TT G T T G TTT T T G TTG T T T T T T T TTTTTT TTCT T TAGAAATAGTTAGTT T TAGGTTGCAG GT TAT TAA GACTCACT TCCG GTA TTCC TGGTTT TGCCG AT T T TAC CGAGCCATTAG ATAATGTGT T TGTGCCCTT TTC CCTA C A G A GAC C AAA GCTTGCT CGCTA A A CTCGCGC TA A C A A ACACC AG TCGC T CGCGGC T CAGCGCTACA ACCA A A A A AGC C C CGC CA A AGC C CAAGCTTACACATCCGTG G G G A GGGTC G G GG TG GTCGGGGGGGGGGGGGGGGGG TCGGGGTGGGCGGGG GGGG G G G G GGGGCGG G G G GGGG G G G GGGG GGGGGGG GGGGGG GTGTGTGGTG GGT TGGTG GGTGTG G GGT C TGGTGGTG G GGTGT TG G G G G GGTGT T TGT TGGTG GTTGGTGCGTGTGTGGTTTT T T T TGT T T T TGTGT T T TGT TGTGT TGTGTGTGTGTGTGT TGTTA G A AAT TG C TGT AATGT TG G G CTT C GAT T TGT T TATA GTGTA TAT T TT C C TTC G CTATC CAT T TAT ACT TC A C G G AATAT T T T T TCCAGCATCCTCAAAAACCCG GCGAGCCGATAATCAAAAAG ACG G TGTG CCCC A ACGAGAAAATACAAGAT GA AC ACATGCCG G ACTAGACCTCTGCG CTCCG C ATG C GTG C C C G G G G G A A G C GTA C C G G CGTTG G G GTG GT TGT CGGTGCGT T TGTGT T TGT TGT TGT TGTGT T CGGT TGTGTGGT TGTG GGT T TGGT TCTGTCTGGTGT TGTGGTGT TGGT TGGTGT TGGT T TGTGT TGT TGC C TAT T C C T C CAT G G T C CTAGTGTCTGCTGCTAATGCTCTTGTACTGCTA ACTCTG G A T A G A T G A G A T A G G T T TCTCGCTTTCTCCCTCTCT T T T T T G T TTT T T TGCTTTTTTTCTTTTTCTTTTTTTTTCTTTTTCTTTTTTTTTCTTCTTCTTCTTCTTCTTCTTCTTTTCCTC CTTTTTTC1182415914928601773564573394 04165652 8 0 1 2 3 3 4 105 7 7 5 2 18 4 3 2 9 4 2 8 0 5 2 3 8 1 858 5 15980637041543293987 5 0 1 1 7 46 4 4 4 7 4 4 6 1 4 4 4 6 4 6 4 1 2 4 4 1 4 4 4 41144863401015666768696071727374757677787970 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 99 9 9 9 9 9 9 9 9 9 9 9 9 9898989898989898989899 9 9 9 9 9 9 9 9 91 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 191919191919191919191

[0064] 7375703928474 4 9 8 4 1 3 7 5 2 392 9 5 1 1 4 764 872 5 7 6 4 1 1 63 2 6 2 2 0657527246978589275632532979 3 2 0 3 0 8 4 0 9 9 83 0 3 7 3 0 2 0 1 0 2 4 8 9 7 2 4 690 359661489 46 06 99 01093960345199 TTT T T G T TTTTTTT T TTT T T TTT T T T T T G T T TGT T T T TTT C CGTC CTT TT T TACCG T GTGG ATCCTCTTGT TCAC TT ACCTCTT T TCC T TTATTCCT TTA TTGTTTTATCTCCAG GATGCT TCTCCAACAAGATACTCACAGTC G C T CTA AAGC C GGA A A ATCC C T CCGCCCA A G A CC A ACGC C CA ACATA ACA A A A ACACA AGT A A ACA ACTCCGG GCTC C C C CGGGGGGGG GGG GCGGGGCGG TT CGT GGGCGGC C CGG G GGGGGC C T C CGG G TTGGGGGC CGGGGTCT TGTCT TCGGGGGGG G GGGGGG G G GCGG G GGGGGG G GGGGGG G G G G G GCGGGTG G G GCG GGGG G GGT T TG GTG G G GTG G G G GTGTG G G G G GTG GTG G GTTG GTCT TG GTT TGT T TTGTG GTTG GTTGTGTTGT TTG GTGTTGT T TTGTG GTGTGT T T T TTGTGTGTGTGTGTTGTGTTGTTG GTTTATTTA TAA AT TC CTATT ATT CAT T T T TC G ATT T C G TTT C C TATATGT T TATAA T T TATGTGGTCTCTCTTTGTGTAATTC CCTAT TAACACAAC AAATA A AAGACCGAAAAGAAAGGAAAACCAAACACG ACGCACGCAAAG AAC TACGA AAGATGAAGATATATACCCGAGTGGTGTA GTG GT CGGTG C G G G G G G C GGT T T T TGTGTGT TGTGGTCGTC C CGT T TG GCC C G G A G G G CGT TC GGTGT TGT T TGT T TGGT CGCTACTGGT TTGTG G GTGT T TGT T T T TGTGT T T TGTGTGTGTGT TGT TTT GGTCTC TTC TAC C C T G G G C C G T GTC G TTC G TTT G AGC CCTGTCTACTCTGGTTCTT A T G A A ACTCTCTCGCCCCCTCTG T G A A G A G T T TGTCGCTCTCC T G T T G TTTGTACATGT AAGTACTGTTTTTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTCTTCTTCTTCTTCTTGTTCTTCTTC C CTTTTTTTTCTCTC98 67814642933155892 0295523122521081 2 659 0 2 0 7 7 0 1 3 2 6 63 790 4 9 0 0 1 3 0 451 5 4 8 1 9 2453662 95 818130862 0 4 7 1 3 2 64 4 4 7 4 1 1 4 1 3 1 4 6 4 3 4 4 1 4 4 1 4 7012451341476869700102030405060708090011121314 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 30 0 0 0 0 0 0 0 0 0 0 0 0 0101010101010202020202 2 2 2 2 2 3 3 3 32 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 202020202020202020202

[0065] 59232518459 5 6 2 2 4 27919 296 7 3 9 9 5 3 2 6 9 2 6 6 153 9 2 6 89 4 1 4 1161314828797342900833628241 5 5 3 5 1 5 8 8 3 3 15 0 1 8 3 0 7 0 6 2 5 6 58333 460 8 3 9 24384041901156555 48 38965086 TTT G TCT T T TGGTT TGTAT TCCGTTTTT T GTCT T TTT TT T T TGT TAT TCTGTA TTTT TTTTCTGTT TTTA TTTTTT TTTCCCG GT G A CTT G TGAACCTT ATCATC A GACC TC C G CCT AAT A T AAAAAA A G A C T AAC C TGA AGA G G A C G AAAC AGGTTCC GACCCC AGCA T A A CTACA AC CA ACA A CTAA A A A A ACACATAA A T A A A ACAAGC TTC CGT GCGG TT CGGC C TTC CGC CGC CGG GC C C C T C C C C C CGGGGGGG A G G GTG GGGGGGGGGGGGGG G GG G GGG TCG GGG GGG GGGGGGGGGG GGGGGGGGCGG GGGGGGG GGGG GGGGGGGGGGGGGGGGGGGGGGGGG GGGG GGGGGT T C T TGTGTGT T TG G G G G G G G GGTGTGTG G GTGGT TGGTGTGTGT TGT TGG GT T T T CGT TGT T T TTGT TGT T TTT CT T TGT T TGT TGTGT TGT T T TG G GTGT TGT TG GTG GTGTCTT ATG A TTGCAT TTGAACATAGTGAT TCA CTCTCGA ATT C CTGATC G C C G C AAAT TTA AT T T T T T TGTTTGA GAG GAG AGATT T C C T TTT TTT TGGT T T T TCG G ATA AT TAATAT T T TTA ATA AAAA C A A A A A ATC A A ACA ATC CAC CCC A A ATACCCA C C ATA ATCGCTG CTG GTGCG ATGTC G GTG G G C C C C C G G G GCC C G CTC G G G C CGTGTG GTG GC TGTGT CGT TGT TGT T TGTGT T TGTGTGTGT TGT TTGGT TGGC GT T TGT T TG GT T TGTGTGT TGTGT T TG GTGT T TGTGTGTTATGT G GTATGTGC G ATTTAGTAC T A GTC CTT G C G C T C GTTTC GTC G A GTT C C CGTTA A G T ATA G A G A A G G T T G T GTA G A T T AC C G C C G C C CCCGCTCTC CTCTCTCTCTCCCACT T T T TAC T T G A TT T T T T T T T TAT T T T T T T T T T T T TCTCTCTCTCT TCTCTCTC C CT T C T T C T T T T T T T T C T T T T T T T T T T T T C T T TTTTTTT6567800358842940 53531 248 576108004305 2 0 7 1 5 304 2 3 6 2 2 32 3 8 4 0 9 7 2 975 5 970 799 5 3 5 3551524211091669 0 7 8 2 5 7 04 4 6 4 4 7 1 4 6 1 4 7 4 4 4 4 4 1 3 4 1 124860304348381544353637383930414243444546474849 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 70 0 0 0 0 0 0 0 0 0 0 0 0 0 04050505050505050505 5 6 6 6 6 6 6 6 62 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 202020202020202020202

[0066] 85 16 42949216805 885 6 295 5 6 6 1 8 9 7 6 2 8 7 3 9 2 8 3 1 3 5 7 94 7 6 0 9 3750822434181994578525921695 9 1 9 8 7 6 3 0 9 4 84 176 8 2 6 9 9 2 887 1 688 4 9 7 9 1 9 6 1421852170857022997064257 GTTG T TTT TTTTT T T T T T T TTT G T T G TTGTT GT TT T G T GTT TTT CTCG CTT CTTGT GTCA TTCTTGGT TTCCCT TACGGT TCTCTT T T TGT A ATCTAC CTAG AT TAT T T T TA GGCGCA TAC GTTAGCT ATT AA G CAA GCC G G A C T T G C ACCTA TGTT CA ACAC TCA ACA ACA A A A A A A A AGCA ACT AC G GCACTCAA GCT AC CATCAG AAC ATTCTGAGCGG GGGGCGG GCGG GCGGCGGC CGGGGC CGG GC C C T CGGGGGG TCGGGTGTCGTGT GC TG GG TAGC C T C TGG GGTTGGTCGG G G G GGGGGGGGG G G GGGG G GGGG G G G GGG GGGG GGGG G G GCG GGT TG GTGTG GTGTG GTG GTG G G G G G G GTGTG GTG G GTG G G G GCTGCTGTTGTGTGTTG GTTG GTTT G C G CT T TGTGTTGTGT TTGTGTTGT T TTGTGTGTTGTGCTGTGTTGTGT TTGTGTGT T CTG GTGTTGTGTATAAA T ACTC A T CGT TAT TC C C CGTA G G C C C A G TATGT TAT T T T T T T T TGATT GGTATA C GTT A C T CGT TAACT T TAT TAAACAAGT CAT AAT G A TGGG GCG A A AGGGGAA C T GAG TA AGAACGA A A A A A A A A C AAC AATG G G GC AACGCCA C A A A A C AAC A AACAA C C CCGTTGTGT TAGTG G A GGT TGTGTCGTAGTC G C G C C A C G G G GGTGTGT T T TGT TGT T TGTCGTG C G AGT T T TC G C CGT T CGTGTGGT TGT TGT T T T T T TGTG GT TGT TGTGT T T TGTGTGT TGTGT T TGTTTCTT G GTT C C C G G C C CTT T C C CTC C TAG G C T T G CTT CTG GGGTATGTTCTGCTGCTTCTACCACTG G G T A T T A A TCACTCTCACTCTCTCTCTCTCTT AGTCT TG GGT TATATATG T TCT T T TGGT TGTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTCTTTTCCTGTTCTTCTTTTCCTCTTCTTTTCCTTTC741861030045 1002506560521991800255129757 9 4 9 3 5 2 0 0 2 9 0 0 99 6 4 0 1 2 795 4 4 2 2 9 3 1 0 5 5 0 56034793108241579225 3 4 7 17 7 4 1 4 4 1 4 3 4 4 1 4 1 1 4 4 1 6 1 4 7 4 6 4 4 7 411015624868696071727374757677787970818283 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 08080808080808090909 9 9 9 9 9 9 9 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 202020202020202021212

[0067] 38 10 67 50 13952 1 6 957 2 3 329 4 3 1 2 4 7 325 4 4 3 9 1 5 7 3 9 3 23 9 2 589258219041885222146489378283 0 6 6 0 2 8 3 2 3 76 099 683 6 1 0 4 1 599 7 4 754 1 8 6 7 3 3 44 5314501818272013855427 TGTTTGTT T TTTTG TT T CT TTT T T T T TTT TCT T T TT TT TT CT T T TTTC GG C C TACAAGTATACGA GTC TCTGT TTTATGT TTT TC GT T T TG GTTTCGCCAGG A GAACGCC C TT T A ACCATCA C CGTT TT AATGCAGAC CAAG A T T ACA A TCAT GACCTACAC AACA AC G G A A GAA A A A AA AG CA AC GCA A AT TAAACAGCCAT G CCACA ATCTCGT C C CGCGTAG G G G T G G CTGCGC CG GGGG C G GTGGGGG GCGGC C CGC CGGGGGGGGGG TT C C CGT GGG GC TGG T GCC GGCGGG G GGTGGGGGGG GGTG G G G GG G GTG GTGG GACGTGT G GGGG GGG G G GGGG G GTGGGGGGGG G G GTG GT GGG G G G G GTG G G G G G G G GTG GTTGTCTGT T TGTTG G GT TGTGTGTG GTGTGT TGTGTGT TGT TGC T T TGT TCT TGTGT TGT T TGTGTGT TGTGTGT TGTGTGTTGTGTTGAACTTCTT C GGCCAT T T TT GGT TA ATC CGA A AGATCG AAC GCACCT TT GTAA AT TT A G A GTT GGGTGT TTA AT T T T TA C C T C G C A ATG G G ATGT TAACAT T T T T T TT CAA GCA ATATA CGTA AAG A TCC ACCACGC A A A A A ATC A C AAC AGAGAGC A A A AAC A A CAA C A A ACTCGTG C C C GTGT T T T TAGTAGTGGCGGTGGTC GGT TC G C A G G C A G G G C G A C G C G G GGTGTGT TGT T T T TGT T TGT T T TGT CGTGTGGCTGAGTGCTGCTGCTCTGT T T T TGT T T TGTG G G GT TGTGTGTGT TGT T T TTGTTTTTTTATTG G GGGTGTGG G T GTG G ATCGGGTGCTGTGTTTTTTCTCACTGCTCGTAC T GTC T CTA A G T ACAGCGGC C C C C C C C GTCTCACTCTCTCTCTCTCTCTCACTCTCT T T T G A AT TAT T T T T T T T T TAT T T T T T T T T T T TCT TCTCTCTCTATCTC CC T T T T T T T T T T T T T T T T T T T T T T T T C T T T T T TTTTT02180975046025308495106703279132345 8 4 3 1 52 09 1 6 2 2 530 28 2 6 1 1 5 9 2 2 9 1 1 8 6 3 1 1026070815474 7903 386 5 1 2 955 6 36 4 7 1 1 4 3 4 4 7 4 4 6 3 4 4 1 4 1 1 1 4 3 6344434015663132030405060708090011121314151617 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 51 1 1 1 1 1 1 1 1 1 1 1 1 1 11111112121212121212 2 2 2 3 3 3 3 3 32 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 212121212121212121212

[0068] 649254 6683 4 63764 1 5 2 4 8 5 3 5 2 213 7 6 1 3 7 2 9 626 9 8 4 7 79 9 852 4038992035 5510383845399161398 7 0 2 4 9 1 5 8 43 9 4 2505 99 2 5 0 5 4 875 0 2 8 0 2 1 536 8 93415380960 22 4319775065 TT TTTT T G T T T T T T T G G G T T G T G TTTTT T TTTCT T TTTGTCAGCT T T TCGC C ATGTCCAGT T T TAACCCACCCCAAT T TCGT TACAC G C GT T T TAATA A AC TT GACCG GT TCTCTCA AG G TT TCAGA GCG CACCGCCCTT CTAGTCG GT TCA TAG T T G CTACG CGGACACACA A C C A A A ACA AGC C CTA AGT G C A ACA ACACA ACAAA A ACGGGGGC C TGG G TGGG GGGG CCCCGCGG GGGCGC C T TGGGGG GG GG GGGGTGATTTC C TCG GG G GGGGTG TCCG GCTCGCGGGGG G GC CGGGGG G GGG G GGG GCTT C CG GG GG G GGTTGGGGGGG G G G GGTGTGTG G GCGTG G G GTG G G G GCG G G G G G GTG GTGTG GTG G G G GTGTGTTGT TTG G GTTGTTGTTGTTG GT T CT TGTGTGCTGTGT T CTGTGTGCTGCTGTGTTGT TGTGTGT TTGTGTGT TGT T TTG GTG GTTTTGTT C A T A C T CGTAACT T TATAT T T TT A C T CGT T T TATAGTTTTTA C A G T CATATAT ACT TAATT G GGT A TTTT TTT GGT T T T TGAGATA AAG AGAGAAAACACTGACAGAATA AAACCCGAAA GTGCCCAAAACGCC AGGAAGA AGAACCCAAGAACA GAACTAAAAAATGTACGTGTC G G GGT T CGTC G A G G C C G GGT TC C G C C G GGTGT TGT T CGTGGT TGCGTGT T TG GGT TG CGTGTG GGT TG C G G GGT T T T TCTTTTG GT T T TGT TGTGT T T TGT T T TGTGTGT T TGT TGTGTG G GTTAGTTTT C G G A T A C C CGGTTTTTATG T T A A A A TTTAG T A T G TTT GTC A A G T G C CTTTC TTGTA A ATG ATT G T C C G A G A ATA T GC C C C CTCACACTCCCTCTC G G GTCCC GTT GTCTCT G A T T T T T T TT T T T TAT T T T T T T T T T T T T T T T T TCTCTCTCTCTCTCTATC C CT T T T T T T T T T T T T C C C T T T T T T T T T T T T T T TTTTTTT61 412142386372929192982913497346 2 3 3 334 6 0 2 7 1 2 3 7 6 500515241101975752614492345456979475141639374268 669 716406 1 6 0 9 2 2 6 2417324441434863401 36373839304142434445464748494051 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 91 1 1 1 1 1 1 1 1 1 1 1 1 1 15151515151515151516 6 6 6 6 6 6 6 6 62 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 212121212121212121212

[0069] 30998867716380275 3 8 5 8 1 5 3 3 8 4 5 3 5 6 9 6 1 1 5 371 8 1 1 58 1 7 3 2 9 1 192456 62606401980864316 5 9 4 0 7 8 6 1 7 4 8 7 84 5 7 5 7 8 2 0 4 339 7 8 1 6 3 9 3 470707614561717226242 13 62804360 TTTGTG T T T G TTG T T TTTTTTT T TCT T T T T T T G T T T T GTTTCTT T TACTGCTT TGT G CT T T TG GA G C TACTCTTGTTT TCCT TGCGT T TAG T TACT TTAT T TCG T GTTT T T TAG CGA AT TCC AA T A G C TTT A GTAT GA C G GTTAG CTGAC G CTGAT A GGTGA CCCAACACCG GTA A ATC C CT A AGGTTC CC A A A AGTTC C CGCA ACGC CT ATCA AAGC CCTACACA A A A AAA A A AATGC C C CGCCGT C C CGC TG G AG GG G GG G G TGG GG GG GGGGGTC GGGG T GGGGGG GG GTTGGGGG TGGTGTGT GGGGGGGGGG GG GGG G G G G G GGGGGG G GGGGGG G G GGGGGGGGTGTG GTGGGG GTGTG G G GTG G G G GTG G G G G G G G G G GTGCTGT TGTTGTGTGTTGTGCTGT TTG GTGTGT T CTGTGTGTGT T C TTGTG G GTGTTGT T TTG GTGTTGC TTG GT TTG GT TTGTGTTGGTTGTA CTCTTTAATC C CTAT TT C A C A T C T CTTTT A G CTC T G CTT TTT T T TAT T T ACTGT T T TGT T T T TGT T T T TAT TAT TAT TACACAGAACAACAGAAAAAAAAAAA AATCACACGAATGATACCCAA G A AAGCACCCCATG A AAGCC TGCA GAAAAGAAC GAACAAGATGTGTA G GTGCG G G C C CTG G C C G C C C A A CAGCAGG G GAGG A GG G GT TG GT TGC T TGTGT TGCGTGTGT T T TGT T TGT T T T T TGTGCT T TGTGT T TGTG GTGT T TGT T T T TG GTGT TGTGTG G G GTGT TGGGA G T C GTTTT G C G T AT T T T T T TTAT T C C C C T T C G T T G T T C T T G C TCGGCTAGTACCA GCGCTT A TCTCGCTA C G C A G TCTCACTCGCTCTCTA A A TGCCC T TA G T T G T A T A T T T TGT T G T T T T TTC T A G TT T T T T T T T T T T T T T T T T TCTCT TCTCTCTCTCTCTCT TC C C C AT T C T T T C T T C T T T T T T C T T T C T T T T T T T CTTTTTTTTTT01 5157525 14443 578715968 0734064083 7 1 6 7 279 0 2 4 142 2 83 389 4 4 459 0 456 5 7 2 013 3 5 9365555445 779 7 7 8 9 079 7 7 84 7 4 1 7 1 7 4 3 4 4 4 6 2 1 4 6 4240424013467514293670717273747576777879708182838485 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 31 1 1 1 1 1 1 1 1 1 1 1 1 1 18181818181919191919 9 9 9 9 9 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 212121212121222222222

[0070] 51 62290 48 92833036483 8 3 7 2 7 9 1 7 8 3 5 2 8 5 7 1 8 8 2 8 4 1 2 63 6173 35 6631606843621500040527109669063628953417999 0 8 0 3 7 9 9 6 3 2 8 4 856842906966792073936779180123 TTAT G G T TTT TTT TT TT TTT GTTTT T TT T CT TTT TTG TCTCT TACTGG CC TT TC CGTTTGT TCC T A TCAGTACTCC GTTTCTATTTC A AGATTCC GCTG C GACT T TGT T TC G GT TTACC C G GCATGCAGCTTTGAC G C CTGC T T CA ACA AGAACTG CAAC GCAG A C G G A G G G G ACACA C A C ACA ACA A A AGAA TT GTACAC AT A AAC AA AAACGG TGG TTCGCGG GCG GGCGGC T CGG TAG GGGGGC GGG CCCGTGTGGCGG GCG GGC CGG G GT C CGGGG GT GGGT C CGT GCGGGGGG G GTG GGT CGG G G G GGCGG GGGGTG GTG G G G G GG GGTGG G G G G G G G G G GTG G GTG G GTG GTG G G GGGTGG G G G GGTG G G G GG GGGTTG GGT TGTGTTG GTT TGTTGT CTG GTTG GTTGTTGTTG GTTGCTGTGTTGTGTTGT TTGTG G GT T TT T TGTGTGT T TTGTGTG GTTT CGT TAATC C G G CTATAT TC C C G A ATT CGAA A TA GT TAT T T ACTGTAT TC C A T G G CATA AATAACT T T T T TTGTACTTTCTA ATC GAT T T AATA C A ATAAGAGAAG AAC AAAACAAGATGAT GAAAAGAAAAAGAAGACGCCACACGAGA GAACCCGA G A CAACCATAGCGTA CGT TGGTGTGTGTG G G GCCG C GTGT TTG GT TGT C T TG AGT TA GGT CGGTG G G G C C C G GGC TGT T TC C G C G G CGTGTGT TGGC TGT T T T TGTTTC G CT TGTG GTGT TGT TGT T TGT TGT T TGT T TGTGTGTG GTTTTGTAG T ATT TTT T C G T G T G C T GTC C G G T C GTT G C CTTTT GCAGCACAT A T TTA G A A A G A TTG C T G G A A A A G G TTT T GC C G G C C CTCGCTC GTCTCCCGCTCTCGGT T G T T C G G TTT TGT T TT T T T T T T T T T T T T T T T TCT TCTCTCTCTCTCTCTCT TC CTC C CT T C C T T T T T T C T T T T T T T C T T T T T T T T CTTTT CTTTTTT56185053 0210096 27968006635 008863 7 6 0 5 2 04 51 757 1860 0 8 7 276 7 0 551 6 5 1 5 48465 45 867 3 4 0 0 29587 3 013 4 069 91 1 6 7 3 3 1 1 7 4 4 1 4 7 714439334346186345601244050607080900111213141516171819 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 72 2 2 2 2 2 2 2 2 2 2 2 2 2 21222222222222222222 2 3 3 3 3 3 3 3 32 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 222222222222222222222

[0071] 53 13597252 9 3 4 47650 8 6 3 4 1 3 7 5 867 816 9 259 2 5 9 3 3 5 7 18 4742603358254868427792 0809 23361312 0112393381917933769 24 088 71 86655 9 4 8 5 1 8 78 31 1443756950406466 TTT TC CTTGTGT TT T T T T T TCT T TTT T T T TTGT TTCTTTTTTTGTTTT T T T TTT T T T T T TT TC TTTT T TT T T TCTTTCT TAC AAT CAA AGGTCCCCGCGAGA T GCC AACCTCTTCCT T CG C CAACCAC CG GCCAG CAC GGAC AAACACACCAC TAAG GGATA CTTCA A C C TGT AT A GA T C G A CCA ACA A A A C A A A ACA AC AAAAA ACACA A AGCCTCTGC C CGCGCGC CGCGC C C CGTTCGC CGCGC C CG GCGC CGG TGG TTGG GG G GGGGGGGG GGGGG A GGGGGGGGGG G GGG G GGGGGGT GGGAGG GGG GT GGGG GGGGGGGGGGG GGG GG GGGG G G G G G G G G GGTG GGGTG G G G GCGTG G GTG GTGG G G G G G GGG GTGTG G GGT T TGT T TGTGTGT TGTGT T T TGG GTGTGGTGGT T TG GTGTGTTG GGT TGTG GT T T TGTGT TGT TGTGTGT T T T T T T T TG G GT T T T TGTAT CTT GTC G A C G T C GCT T T ACT T TATAT T T TC AGT TC C C C CGT T T TATCATT T A G GTATATT T G GATGTGT ACT T T TGTG A AGA T TTA AACGACACTCCA GATAT A CG GC A AACAACCCAAACATAATAATGCTAACAAGATATATGACATA A GATCTACAGAGC G AAGACATATA C C ATA C G ATC C C G A GTG CTG CTG G GTATGTA G C A A G G G G AGT TTG GCGT T TGGT TGTGTGTGTGTGCGTGG G GT TGT T T T TGT T TGGTGCTGCT TG GT TGT T T TGT TGT TGT T T T T T TGT TGTG GTGT TG GTTTTATTTGTCTC A G T G A A C G T G C G CTGTTTTTCAGTACTACACAA G A A A G CTTAGAGGGGTAGGTTATTCATACTATTATAAAC C G G C C C C C C C C CTCTCTCCCTCTC GGCCCTCTCT T T T T C C T T CT T T T T T T T T T T T T T T T T T T T T T T TCTCTCTCTCTCTCTCTCTCT T T C T T T T T T T T T T T T T T T C T T T T T T T T T T T T TTT6039524562084957902723295134524376274 612 2 4 1 6 7 1 5 1 2 0 8 21 0 8 5 2 0 1 6 2 6 6 7 7 4 1 3 0 36298 55 985221841105909 4 5 0 6 14 1 6 6 4 1 1 3 4 1 2 3 3 4 4 4 3 4 4 7 2 4 4 4 4 4 144515144340383930414243444546474849405152 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 12 2 2 2 2 2 2 2 2 2 2 2 2 2525252525252525262626 6 6 6 6 6 6 6 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 222222222222222222222

[0072] 60393040 37 7164218 8 6 2 6 3 5 8 4 7 997 2 9 5 7 3 9 8 7 1 6 2 3 5 42 9 1 7 3 4 380775099901246908133819 064 7 2 9 5 2 1 9 9 1 9 58 8 5 3 276 7 8 8 6 6 6 7 0 8 3 3 9 5 14 89 7591350468553096019477670 TTTTTTTTTT TTTTCTG TTTTTT TCTT TTT TTT T T TT TT T T G T TTT T TTGTT TACGTC T CTT C AAGT A GT TC TC GCCGCT TACCCT TTCGCGTCTTTCT T TCT T TTGGGTGTT TGCT TTTTT ACCAGTCATC ATCAC TAT TCC C GAGTT T G G A CAA ACATA A A AC CAATT A A A A AGA CTGCAGTCCTTGCC GAGC C C C CCT C C CGC C T CGCGCGC CA ATACAA AAC A A CAA A ACGCAGC C C CGC T CGC TCT C C C CGGGG G GGG T GGG GGGG GGTG G GGGG GG G GGGGTAGG TCT G G GGGG GGGGGGGTGGGGG GGGGGG G G G G GGGG GG G G GGGGAGGGGGGGGTG GGGTG G G G G G G GT GGG G G GTGTG GTG GGGGGG G G G G G G G G GGG TGT T TATG G GT C TTG G GT TGT TTGTGT TG GC TTG GTGTGTTGTGTTGT T T TTGTG G GT T TTGTGTGT CTGTGC T T TTG GTTGTGTGACTCTT CTTTT C C G AT TT CTA C C T T C T GTTTT T A T T T CTC A G GTCT T T T T T T T TGT T T TATATGT TATGT T T TGA T TAT TAT T T TCTGATA A GTATA A ATGGA ACAG A AAT G CG A AGCTAAAAC CA G G G AA AACTA ACCGA AAC ACAACC A A A A A ACCG TC A C A A C CA TAA CCTGTGGTCAAATGT T TA C G A C GTG G GT T T TTGTGTG GT TG A C G G G G G GCTGTGT TTG GT T TTG GTGTTGTTGTTGTC C C G C G G C CTGT T T T TTG G GTGTGT TTGTGTTGC CC GCTGC TCTG GTCCTCG GTTGC TTTTT G C GTT A T GTT CTC G C G C C ATTTT C A G C G G GTCTTTT CTA A A T G T C C A A A G G A G A T A T T CCT G T T T A TA T A C G A T GTGGT A T TC C C C C C TTCACCCGCTCGCTTTCACT A G A T T A G TCG TGTTT T A TT T T T T T T T T T T T T T T TCTCTCTCTCTCTCTCTCT TC CT TC C C CT T T T T T C T T T T T T C T T T T T T T T T T T CTTTT C CTTTTTTTT51 09059952155482337 5 6 04253122806 62 3 9 2 5 4 1 5 9 5 0 7 2 0 64 845 0 2 8 7 3 7 6 2869068 4 4 1 3 55 71455138599 7 0 6 9 5 7 9 2 44 4 1 4 1 6 4 3 1 6 3 3 4 3 3 4 1 2 32497932476563411831127374757677787970818283848586 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 52 2 2 2 2 2 2 2 2 2 2 2 2 2828282829292929292929 9 9 9 0 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 222222222323232323232

[0073] 9053418011212 6 3 9 529 3 4 2 7 6 7 6 3 7 1 290 6 9 682 8 2 3 1 1 38 6 3 3 3696169549069325569552382481 9 4 4 1 8 8 2 2 6 8 20 0 0 8 4 0 883 1 3 3 997 6 0 3 5 8 3 3843353 58 727309 24 659441357927 TTT GT T TT T TTT T TTT TT TT T T G T T T T T T G T T TTT T TGTATTG A GTACCCC AAAGAGTT TTAG AGACC T TCCGC CAT TAG T G TT TTC CCCGCCC T CT T T T TA CGGAA T CCCTCACTT T T T T T TCGA CACGAG TTTGGGTC CCG GTAG GAT T TTAC A C GCCGCTGCAACACTTACG ACA A A A ACACA A AC CAA A A C A A A A A ACC A A A ACA A ACG GG T GGC GCG G G G GGC CGGGGCGG GGGC CGG GC C CGG GGGGGG GGGC TGG TCCGC C CGGGG GCGG GT C CGTGG GCGGGGC CGG GGGGGGGGG G G G GGGG G G G GG GGG G G G G GGGGGGG GGGG G G G G GGTGC TGTGTG G G G GTGTG G GTG G G G GTG G G GTG GTG G G G GTG G GTGTTGCTGTGTGTGTTGT TTGTGTTG G GT TGT TT T TGTGT TG GTTGTTG GTT TGT TTGTGTGTTGTGCTGT TTG GTTGTGT TTGTGTGTTA CAT TG CAACTAATC A CATC A G C G GAT TAT TGA T T T TGC C CTT TT AAT TT T T G C C CTATC C G A T T TATCA AT T T TGT T TGT TAT T TGCCAGAAAAAGAGGCTAAAATCTCAAG GACCC CG AA AT TCAAAACAAATATG G AATCGATACAAAACACGGACAGAATGAACGACTAGTGCGTG GTGGCGGTCGTA G C GGT TGTGTG C G GGT T T TC G G A G AGT TGT TG C G G GGT CGGTGT T T TC C G G G G C GGCGT T T TGT TGTGTTATTCT T T TGT T T TGTGTGTGT TGT T T TGTG GT TG GTGT TGT T TTACCG G G G C A C GGGTGTGTGTATACACTC TTT GTT A G T TGA C T G T C C A AGCATACTACTTTAGGCTCT T C T C G CAT G A A A A GC C C C C C C C C CTCACTCTCTCACTCCC GGCGCCCT T TCT T T G C C AT TAT T T T T T T T T T T T T T T T T T T T TCTCTCT TCTCTCTCTCTC CT T T T T T T T T T T T T T T T T T T T T T T T T T C T T T T TTTTT802761864785263904532931234123680 3 5 62 50 9 5 9 5 45470 0 65 5 6 1 5 1 2 4 9 6 8 4 8 0 1 106347537 5894 66702 2 7 553 755 4 0 74 1 7 4 7 4 4 4 2 1 3 4 3 1 4 1 3 3 1 7 1 134147611344113436070809001112131415161718191021 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 93 3 3 3 3 3 3 3 3 3 3 3 3 3 32323232323232323233 3 3 3 3 3 3 3 3 32 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 232323232323232323232

[0074] 23 10445819742821 3 5 7 9 8 550 6 9 4 4 6 1 6 6 6 3 5 5 3 4 5 9 442 87 41149819693638 74 764499147266410080 25 07454093472770799 8 5 6 4 2 5 5 0 7 5 854161163083947233704372 78 94 TTTTT TG T T T T TTT TT TTC TT GTG G T G T T T T T TTTTTC ATTCTCTGA ACCTCTGTGATTT TG CC TT TAGCTTAT TCG T GTGTCTTCC G ATCTGATTATT TACT TACT T T T T TCC CTG GCG CCTTAC GGCA ACGCCAAAC GAG A C G GAAA A A C CACA A ACA A ACACAT A CTTT CTCAGC AT GTA ATA A G A GCA TCACAT A C A A A A A ACA ACGGCG GGCTTTT C CGG T T GGG GCGGCGGGGC CGG G GC TGGGG GGGT GCGGTGTGC TGTT CATTGTGTC C C C CGG G GGG GGGCGG GGGGG GGGAGCGGGGG G G G G G G G GGGG G GGG G G GGGGGGGGG G G GGGTTG G G G G G GTG G GTG G GTGTG G GTG GCGGTG G G G G G G G GTG GTGGTT TGT T T T TTCTG G GTGTG GTTGTTGTGT TTGTGTGTGTTGCTGTGTTGTG GTTGGTTGTTGC T T TTGTGTGTGT TTG GTGTTGTGTT TTTAGTCTTCTCTCTTTTCTTTT C G G G AATATAT A TGTT C C A CTAGTAT TAT TA CT TC C T T C ATC C G A CATATAT T T A T T T T TA TGAA ACA A A AAC CCACGA GCCAAACAAAAG CAACA GAGAGAAACGAAGAAA AT GAGAGAAAA A C ACAACAGATAAGGAAAATAGAATGTGCCC C C A G AGTGTGT T C T TGGT TGGTGCGTC C G G G C G G GCCG G G CGT T TGTGTGT TGT CGT CGT T CG A G G G G A GGT T T T T T TGTGCTTGTG GGTTTGTTCTGCTTTTTGTGTG GGTTTTTTTTTGCTTTGATTTGCTTTGTTGCTCTG G G G GCTTTTTCTTTGCTCTTTATACTATTA TTG A A G A T A A C A G TTA G ATT CAG G ACC A T A A A A GC C C CTT CTCTCGCACCCGCTCTCGCG TGC TGT TTTGT T T T C T G GT T T T T T T T T T T T T T TCTCT TCTCT TCTGT TCT TCTCTC C C C C CT T T T C C T T T T T T T T T T T C T T C T T C T C T TTTTTTTTTTTTT697821744354 254 12575000563 5 3 29 534 9 5 661 7 0 6 0 6 2500 9 4 1 8 5 344 952 9 9 5 5 119513 5559 13 6 4 1 313 8 3 5 5 3 1 216 61 2 2 1 6 6 4 3 2 3 4 4 6 29711976756434401345144210414243444546474849405152535455 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 33 3 3 3 3 3 3 3 3 3 3 3 3 3 35353535353636363636 6 6 6 6 6 7 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 232323232323232323232

[0075] 65164020232014967 2 4 2 8 8 1 4 3 7 3 2 7 9 7 370 6 4 8 6 3 7 6 9 57 8 3 4 5 6 2 0016527746347502920201 5 7 8 6 5 8 2 7 6 8 5 9 1 93 7 9 7 1 4 9 0 0 2 7 8 4 0 8 0 2 2990535834272 13 197307828114533495 TC TTTT TT T T T GTT GT T TT G TTT T T G TTT TT TT T TTT TAC A GT TTTA AACAGCAT TTTCCCGCATG GT TC GT T TCT T TC G GT T TT TT T TT GT TGCAA TT C GGG GTC AT AT CTCT CT CGC CG CCCAAG GTA AC A G TAACCACACA T AC GCCT CAAC AC CTTATA AAAAC A G AGA ATCT A GCT A CCA C A AGT A A A TCTAAAGACAAAAGAGC CGCG GC TT GC TGT CCTG CT CGC TTCGCGT CGCGC C CGCGC CGGGGGGG GGGG GGGTC GTTG TT GT GGGA G GTGGGGGG GGG GG GGGT GGG GG GGG GT G G GGGG G GTGTG G GT GGG GGGGGGG GCGGGGTG G G GTGGGGG G G G G G G GGTG G GTG G G G GT GGGGGGGG GGGGGG TTGGTGTT TGCT TG GC GT TGT TTGT A CTG GT TTTTTC GTTGTTGTCTGT CGTG G GT TCTTTTTC G G GT CTG GTGTTGT TTGTGTTG GT T TT TGTTCTT GTT T C T T C G GT TGCTGTTTGT TATC GTGTTGT T TGT TATAT TAGT T TGT T TGT T T T TATATAT T TGT T T TAAT TGG AACGCCACAACCCCGAAGACCGAACAATCGAACA ACACTCAA A GACCT TAATCACGAGA G GAACGAA GA AC AA CAAACTA ACATCTC A A C CGT T TTG G GT TG G CGT T TGGTA CGT CG C C C G CAAA C CGT CGT C TGT T TGT TG G C G C GCC G C GGT TGC T T TGT T TGT CCCGT TGCTACTCTGGT TGC GTGCT T TGC G GTCTGCTCTGGTGTTTTGCTGTTCTGGTCTGGTATGCTG GTTTTCTG GATCTTTCTGGT TCGATC G A G C C CAG C ACG G G ATG TTT G A CGA A TGA A A A A G ATT AC CTCTCTCGCGCTC GGCGC GTCTTTC GAGT T C C GCT T G T C A G T GT T T T T T T T T T T T T T T TCT TCTCTCTGTCTCT TCTCTC C C C C C CT T T T T T T T C T T C T C T C T C T T T T T T C T TTTTTTTTTTTTTTT68 805 405834440321045854372361470370663 211 9 395 563 0 58 1 8 3 7 1 5 730 4 724 5 02808364 286644358 4 2 7 4460124614692 5 872 4364454 8 055 4344153 7 41 6164757677787970818283848586878889 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 73 3 3 3 3 3 3 3 3 3 3 3 3 3 38393939393939393939 9 0 0 0 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 232324242424242424242

[0076] 8177914951 78 1 9 83745 5 4 4 5 1 6 964 2 5 1 6 2 3 7 1 6 7 4 2 5 2 25 3 7 1 5952888737827910648184845686 0 9 2 2 0 3 7 8 4 3 25 5 9 5 9 538 5 6 47177 4 5 7 1 4 8 552 6 8156472412750632990591930 TTTTT T T TT G T TTT G T TTT G T G T G T T TTT T T TTG T T TC TGCCCAGC GGT TCCT T TGC A TT TCCT TTT T TCCCAGTCCCTT TGA TTGCT T TGAAGCCC TGTCT TCTCG GATCTCT TGA GGTT ACACCAAAGCCCTCCATGTAGC C AT A C A AT AATTTC G A T TCT A A G ATG TTT ACTGACC AAATA A ACA T AAT A C A A AC AAA A A A T A A ATT ACGGGGGGGT CGT GTGTC C CCG G G TC CAGGG GC TGG TCG CGT CGTGGTGTC CCG GC C C C CGGGG G GGGGGT C C C TGTAG G GGTTGGGGTGGGGAGG GGGGGGGT TGG G GGGG G G G G G G GGGGG GGG G G GGGGGG G GTG G GCG G G GCG G GTG GCG G G GCG G GT GGG G G G G G G G G GTTGATGTGT TTGTGTGT TTGTGT TGTGTTGTGTGTGTGT TGC TTGTGTGT TTGTGTGT TGTGTGT TTGTGCTGT T TTG G GCTGTGTTCATG G T A CAGTGTGT ACTT ATAT TT ATTGTAACTGTC G C T T CGT ACTAT TATAGTCTGT TTTC T G G ATTTC C C GGT T TAT A T T T T T AAAGAGACAATCTAAG G GAA AC ACTCTC CGCTAGAACACAAAACCAAAG GATATCAA AAC TATG CAG AACGG A AAC CCTA CAAACATGGTG A CTGTGTGTG GGTGCC C C CTC G G G AGT T TGT T T T TG C GGT TGTGGCG C GCC A GCC C GAAC G G AGT TGT T T TGT TGT T T TGC TGCTGGTATGTCTGTGGTGTTGCT TG G GC GT T TGT TGT T T TGTGTG GT TGTG G GTGTTTACAG GAG TGA A A GT T T G G A C G TTC G CTC T ATT GTCTCTACTC GGA A C C GTA CGC GAT T G T G A A G T T C A TTGC C CTC CTCCCCCTC GTCTCACTC GCCGC GTCG T T T G T T ATT T G TT T T T T TAT T T T T T T T T T TAT T T TCTCTCTCTCTCTCT TC C C A CT T T T C T T T T T C T T T T C T T T C T T T T T T T T CTTTTTTTTTT41 26 0 53 14515746254715135971669656575539525306 5 1 6 1 5 8 0 0 9 8 5 5 249 67737649746 980 653 56337 4 8 5 3 594 9 32 3 4 6 4 7 1 1 4 6 4 4 3 3 5 2 6 7010411542477115367248090011121314151617181910212223 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 14 4 4 4 4 4 4 4 4 4 4 4 4 4 42424242424242434343 3 3 3 3 3 3 3 4 42 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 242424242424242424242

[0077] 898563716016672 6 6 598 7 5 1 2 6 6 8 4 5 1 3 4 651 6 5 7 3 7 5 2 19 0 2 8 5 9 458501811815474553160762 4 8 6 6 3 3 6 2 5 2 7 1 64 2 0 8 6 5 4 6 2 8 0 137 1 4 7 4 7 5966881059231 54 8950492805929820 CGT TTT TT T T T TT TT T T T G T T T G TTT T T T G T TTT T T TTT TT GGCCT T T TCCC CTCCCC CTG GT T TAC GGC TTATA A ACC CT T T TCG CTA GCG CGC CAT TGACCCG GTGGGGCT TAGA CT T T TGACGGT T T TTT T TTTG AGC CG T C C TGAAATCAGAGT TTT CCGCTACTA ACA AGAA A ACACA A A AGCA A A C A A A ACAAT A A A A A AGAA ACTCGC C C CTGGGGGGGG GCG GCGGG GGC CGG GC TGG TC CAGGGC TGG TCAGC CGG GC TGGGGGGTC C C C C CTGGG G G G GC CGGG GGGGG G G GGGGGGG G GGGGGGG G GGGG G G G G G G GGGGGGGGGGGG GGTG GTG G G G G GTGTG G GGTGT T T TGTG GTGT TG GGT TG GGTGTG G G G G GGT CGTGT T TG GGT TG G G G G GGGTG G GTGT T T T TGT TGGTGT TGTGTGTGT T TGT TGT T T TGT T TGTGT TGT T TG G G GT TGT TCTA CAT TC CTCG GT TCTCTTG CTG C C C A C C T T C T A T C C A TTCTGTA T ATT A CTATAACTAT TGT TAT TAT TATAT T TAT ACT T T A T T T TACTCAGGATG AACATCCGAC GAGATACTCGACTCAGCCCGAATAAAAA AAACAAAAACCTAACA G C G AATAC G ACTA AACACCGACA G G A C GCCGGT TTG GT T T T T TG CGTGTC C C CGTGTGTGCC G A G G C G GGTGTGT T T T T TC AGTGTG ACGT TCCTCTCTGTATCTGGTGCTGCTG G GGTTTTTGCTGTGTT ATGTGTTTTTATCT TGTGTGTGTGT T TGTG G G GTGTGT TTATACTAATGTCTT G G A G G A AT C C C C CTT C G G CTCTTTT C TTT A ACG C A ATC T T G A GTG A T T C G T C GC C C C C C CTCGCTCGCACGCCC GACGCCC AA G A G CGT T T T A A T G GT T T T T T T T T T T T T T T T T T TCTCTCTCTCT TCTCTCTCTC C C C CC T T T T T T T T T T T T T C T T T C T T T T T C T T T TTTTTTTTTTT5929592369 057096707 255020608083 0 5 4 5 3 1 7 608 9 6 5 1 7054 4 9 7 4 243 1 2 1 195 4 0 5 57 6569762057627 742 4 9 7 3 6 981 76 4 2 1 4 3 1 1 4 3 1 3 6 3 1 7 3 4 1 10365441111833301212434445464748494051525354555657 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 54 4 4 4 4 4 4 4 4 4 4 4 4 4 45454546464646464646 6 6 6 7 7 7 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 242424242424242424242

[0078] 82889626531448 15 777 8 1 1 5 4 8 6 2 4 5 7 1 5 7 2 1 3 4 4 7 4 1 7 35 7 3 3 2 8 1 4557062391423597975445 3 4 3 9 1 7 0 3 2 8 6 7 0 45 6 3 3 5 8 1 237 8 3 1 9 9 1 4 7 5 8446823396469980147951599345970 TTT G TGTTT T TT TTTTTCTG T TT TT TATA TTTTTT T TTTGTT TTT T TGTTTTT T TTT T TGTGG GTTTTTTTTT TA TTTTT GTCGAGC C CCACGT GC C GT AT AT CCTC GT T CT GGACCCCACTAAC G G AATGT AAG C GCTT AC G TAT T GAA ACC G C GCT GGA C G TCTCACC A ACA A ACT A A ACAAAA ACA A A A A A A A ACA C CGAA A ACA AG GT CGC C C T CGCGGC C CGGAC GCCGC CGC CGCGT TTC CGCGC CGGGTGGGG G GGTAG G GG G GGG CGC GGGG GGG GTGGGGGGGGGGGGG GGGGGGGGG G G G GGGGTGTG G GTG G G G G G GTGG G G GGG G GG G GGGGGGG G G G GGTGCG GTGTG GTG G G G G GG G G G G GGG G GTG GG GC TGT T TGT TGTGGT T TG GTG GTGT T TGTGCGTGT TGTGGT TTATGTGT TGTGT TGT T T TG G GT T TGT TGTGTGT T T T TGT T TGTGTTG C G TATGT T TC T T C C A AGT T T T TGT T TTTG TATCT A TTAT TC CAT TCTT G T G G C T ATG G GATGT T T T T TATATA CT T T TT CGTATG GAAGAATACGAAT GGAGA G CA GAG GA GAATG GT A A CA G GT CAAGA CTAA A A A C C C ATCT CC A ACA A AAC C ATAA C C CC AAAC A ACATGGTCCG GTG GT TG G G C C C G CCCC GGT T T CGTGTGTGTGT T TG A G G C C A G A CGCGT CGT T TGT T TGTCGCCGC CCG C GGT T T TAGTGGTCTATTGCT TGT CTGCTGTTCTCTCTGTGTG GTT TTTC ATGGTTTGGTGATTTGGTGGTCTGTGTCTG G GGT T T T TGTCGTCATTGGATACCAACA G C A T A G G A G T A A T T G A G TT T T G A TGT A A A A GC C A C C C C C GGCTCACGCTCTCGCTTTCTTA C C A T T G GTT C A G G TT T T T T T T T T T T T T T T T T T TCTCTCTCTCTCTCT TGTCTC C C C CT T C T T T T T T T T T T T T T T T T T T T T T T T C T TTTTTTTTTTT01 406305193146139 09056 57833779 9 9 0 1 7 2 7 905 5 5 6 20 5 555137601313441735 067346 736115427155746458 3 0 3 1 407716113520124 9 758 4 5 76676115182 758526777879708182838485868788898091 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 94 4 4 4 4 4 4 4 4 4 4 4 4 4 49494949494949494940 0 0 0 0 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 252525252525252525252

[0079] 4550 88 884876776 2 3 2 681 5 336 6 8 3 5 2 4 8 3 8 7 9 2 9 7 5 7 4 51 4 5 5 2 61041245548029942027431410 8 8 8 3 4 5 3 3 0 2 3 68 7 077 0 8 0 3 6 4 7 8 610 1 055 2 6 6 952336963669885268236613511 TT T TT T T T T T T T T T T TTGTT T T T G TTT T T T T T T T GA C TT T T T T TCTCT T T T T TT CTATCTCT TCT TGT T T T T TTT TCTG GC T TCT GT A CT CTGTCATG GCC G A GCGT ATG CCGTTGTGTGGAATTTCGGA G AGT T G TAA T A T G G CAC TAACGAAG A AGT TGGATCCACACAAAAA A A A ACA A A ACA TTACA A A A CCAACA A C A A A A C TGGGC C C C C C CGGG G GGG GGGGGCGGGGC CGGGGCGG GCGG TGGGCGGCGGC CGGGGT CGTGG GC C GGG G CC C CAG GGGC G TGG CCTAGGGGGGGGGG G G G G G GGGG G G G G G G G GGGGGGGGGGGG GGGG GTGGTG G G G G G G G GTG G G GTG GCGTG G G G G G GTG G GCG G G G G GTTGGT TGTGTGT T T TTG GTGTGTTGTGT TTGTGTTG GTTGTGTGTTGTTGT TTGTGTTGTTG GT TTG GTGT T TTGTGTGT CTG GTGTAGCT TTTT CTC T T T C G C TTA A C TCGT T T T T T TGT T T TAA TGTATGATG T G A CTT CTGT TG T A G G ATA C TGT T T T TAT T TAA A T T TATAAAA G A A AAAAATAACTCAAATAAAAAGACAAAAACAA GAAAGAGGAGAGG AATACAAGAACCGG AAC TAGC C G AAA AAAAC GAGATG G G C C G G G G A G GCGTTGT T TGT TGTGTGT TGT TC G G GGT T T TG G G A G G C GCGGT T T T T C T TC G GAGG GAGG GGT T TGT T T T TGCGGTG GGGTTTCTGGTCTTTGTGCTCTGGTCTG GATTTTT TGG GTG G G GTTCTCTCTG GTTCTTTG GGTCTATG G GGTTT TGCT TGTGTACCTCTTCTC T A G A G G A A A A T ACACGCGCTCGCTCTCCCGCTCGCGCGAGTTACATAGTTC C T A G TCT GTT G GAG G T C T T T T T T TT T T T T T T T T T T T T T T TGTCTCTCTCTCT TCTCTCTC T C C C C T GT T T T T T T T T T T T T T T T T T T T T T C T T TTTTTTTTTTTTTTTTT431842210853 028 6 14471 913 15 552 4 61127 8 0 0 5 11 55 92 9 0 0 7 0 550 95032 5 9785 1 785 6 5 884 991 7 8 8 7 5 44369 7 44 2 1 1 3 4 4 4 154936701514467118257010157970111213141516171819102122232425 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 35 5 5 5 5 5 5 5 5 5 5 5 5 5 52525252525353535353 3 3 3 3 3 4 4 4 42 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 252525252525252525252

[0080] 13 11 9535956 526 5 4 1 9 7 9 4 3 627 5 4 2 4 235 1 9 144 8 5 9 7 4 11 8 30052572040265958378855080980163 7 4 9 2 4 3 3 1 66 034 1 0 060 288 5 1 1 9 5 5 1 5 882 0 8 020 63 962332 81 944880874224 TTT T TTT TTTTGT TC GTTTTCT TC G GTT TGTTCTATGTTTTTCATA GTTTGT TATTT TTGTTTATCTTTTTTT TGTC TTTCGC CAAGCC TTGGG GGC A G GAC C CCTGGACTTC GTGT G TA TCGATCTCAG C G A G T GGT T C A G TGGCCA A AGCGC CC A A AGTTCGC CC CGT TG ATGCCA AT A GAGGC CA AGC CATC AT ACTTG ACA AGACGGCGTGC CATGCCTACA A AGGAT C AAAGCGC C C C CA CGC GGACG C G GGGG A GGGGTT C G GGGGGGG GTGGGGGGGTAG GG G G GG GGGGGTGG G G G G G G G G GGTGGTG G GGTGT TGGTG G GGTGT TG GG G G GGT TGG GTGGTG GG G G G GGT TG GG GTGTG G GG G G G G GGGT TG GGGGGGCGT TG G G G G GGGGT C TGG G GGG GGTGT T T T TGGT GGGTT T T TGT T T TGT T T TAT T T T T T TGT TGT TGTGT T TGTGTG GT T TGATTTA C T CG ATC GATAAT TA G C GGACGTAAA T TTGCTATGTGATA G C GCATAAAACT TC TGGCGTAATA C ACAT T TC G C C C AGGTA GT AA ATT C G GGATCT T TTG ACGT T T T T TCATA A A ATGA TCATGACCA A C A A C C C A CTG G C CAGC A C A C A CCC A C AAC C A AACTATA AGA ATCGCGTGTA GGT TCGTCGTCGTGGT TGCCGTG CGT TG CGTGTG CGTGTC G C G C C G G C A A A G G CGC TGTGTGT C T TGT T T T T TGTT T T TGT T T T TGT T T TGT T T T T TGT T T TGTGTGT TGTG G GTGTGAAG T GCG AATC GGACTC G G C GGGTGTACTAGG G C GTGTGAATTG CGG GAAAATAGAGGGGTGCTC A TTCTC CTC GTTTA C A T T A C G TCTT C C C C G C C C G A C C CTCGCCCGCCTCCTCTCTC GC A T T T C T T ATTTTTTTTTTTTTTTTTTTTTCTCTTTTTTTTTTTTTTTCTTTTTTTTTCCTCTTCTTCTTCTTCTTCTTCTTCTTT711621023754697916588185251156895965 09 7 8 854 0 5 5 6 5 1 3 7 01 5 7 0 5 9 4 2 0 7 8 9 3 4 0 1 3 9 49 95997201 74 458416058 8 6 7 6 63 7 2 4 1 3 6 4 3 1 6 7 6 4 4 4 1 2 6 2 4 4 6 1 3 40101514314814454647484940515253545556575859 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 75 5 5 5 5 5 5 5 5 5 5 5 5 5 55565656565656565656 6 7 7 7 7 7 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 252525252525252525252

[0081] 38 962967074 33 51814 8 4 9 4 1 1 6 1 5 8 1 9 5 2 8 2 3 5 9 4 3 634 3 90 43116735 03 2409906482217402624862246191453069198878 0 6 0 9 6 1 3 6 0 1 8 318621839473589947978161 14 0199 T GTTTTTTTC T TG T T T TTT T T T T TTT T GTTTT T T G T TTTATACTATGAC CGTGCT C T TCCT T T TCACT GTG ACTGTT T TGT T CTCCCTCTGGT TAT CT T T T T TG GGAC C ACTCCTGC GTATAAC G A CTG GCGCCA C AT G G G T GCCGGG GTTACCA T CTCCT C A GCA AAG GC GCCATT ACAGC TGC GC AGT CA A A AGC C C CA A A A A A A AGT C ACA A A A T A A A AG GCGCGC C CGCGC C T TT GC C C C TTC C CGCGGC GGGTC G GTT GG GGG G G GG GG GG G TT A GGGG GGGGAGGGGGGGGG G G G G G G G GGGG G G G GGGGTG GG G GGGGGG G G GGGG G G GGGGGG GT CGTG G GTGTG GTG G G GTG G G G G G G G G GTGTG G G G GCG G G GTGGTGTGT TTGTGTGTGCTGTGT TTGTG C A A C ATGTTGTGTTGTTGT T TTGTG GTTGT T CTG G GTGTGTTGT T TTG GTGTGTTGT TTG GTTGGT TAA T T TC C G T G C G C C ATGTGT AA C GTCTT C TTGCT T T ACTGTAT T TAT T T TATTTC C T C CTGT T T T TATT TTT TTATGGGCTACAAG CAC TATG AAG C CA GCGCG A AA GATA G GT AA AAAACAA A C A A A C A ATC A A C ACATA ACCA AC A A ATACC A AAATC AGGTGGTGTATC G G G C G A C G G CTG GTGTTGT TTGTGTTGCTGTTGT T T TTGTGTGTGTACTGTA C G G CCC C GTGT T T TG G A C ATG G GT T T TTG G G GTGTTGTTGT T TGTG GTGCG C GCCTGT T T TTG GTGTGATAT G G G T C G C G T C C G A ATTTC GTATCTT T G A CTC C A CTT C GTCCTTG GTCATTAGC G G C C G G G A G T T C A T CGCGC A A A G CAA A A TC CTT C C G CACATTCGCGCTCTCGCGCT T G T T AA GG G T G AGC C C TT T T T T T T T T T T T T T T TCTCTCTCTCTCT T TCTCTCTC CTC C C CT T T T T C T T C T T T T T T T T T T T T T C C T T TTTTT CTTTTTTTT886077824948 7040471 5 0 53612 5 2580 0 4 3 0 51 3952 6 5 6 8 29 0 5 2 7 6 956 7 1 3122031 4 48731480 4 7 6 10194 417 9 1 0 3 4 42 1 7 4 3 7 3 6 4 4 1 1 34354814667442397516192118797081828384858687888980919293 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 15 5 5 5 5 5 5 5 5 5 5 5 5 5 59595959595959506060 0 0 0 0 0 0 0 1 12 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 262626262626262626262

[0082] 227919825130 96 962 5 2 6 5 1 8 1 2 6 1 6 2 1 8 4 7 2 9 5 1 674 2 9 41 3 4 4 2 9 444629031874910658257270 3 2 7 8 3 3 8 6 4 3 4 5 92 7 9 8 1 1 419 4 5 0 7 2 4 8 3 8 7 54858722323326136289983 45 263818 TTTATT TCTT T TTT T T TTT T TTT G T T T TTTTT T TCT TTTTA CCT T T TGC ATC G A AT T TGAATAGAGG C TTGT GTGCGCATGCCT TCTGAATCGCT T TTGCGCTAGCT T TAAG T C GTGAACG T AGA CT TTTCTATGT T TTGTTC TTACC CAC G CGTAGAC GGC CTAACACACA A A AAC A A A ACA A A ACA C A ACAA ACA CGAA ATC A A A A ACGGGGGC C C C T C CGG G G G TCGGGCGGGGGGACGGCGGGGC TGGGTG C C CCATG GCGG GGGTGTC C C T C GCG G G TCG ACAGCGG GGGGG GGGGGGGGGG G G G G G G G G G G G GGGGGG G GG GGGGGGGG G G GGTGTG G G G G G G G G GTGGTG GTGTG GCG G G G GTG GGTG G G G G G G G GTTGTTGT T T T T T TTG G G G GTGTGTTGTGTGTTGTGTGTTGTGCTGT T TTGTG G GTTGTGT T T C T CTG GTGTGTGTGTTGTTGTGTCTTATCTCTTTC T G C G A T C C C T TTT GTTTC T T ATT T C T C T A T CT AGA T T T T T A T T TCATAT TGTGTATAT T T TGTATAT T T T T TAT T TGCGCCAAG A AACCC TG A C GCCCGCTCTGATCAAGAATAGAGAAAAGAAG A AAT TCC GAGAAG ACT CA AACAAACTCGGACGACCGATGAGTG C G CTGT T T TC C C G C GGT TGT T T TG G G G G GGTGT T T T CGAACAAG G CAGTGT T T TGT CA G A C C G G C GGT T T CGTGTGT TGTGTTGAATGCTGTTTTGCTCTGTTG GCTCTTTATGGTG GCTTTGTTTTTTG GGTCTGCTTTGGTTTG G GCT TCTATCTGTGGTCTCTGGCGATACT A A ACA A G C G A C G C GTG T A A A G ATCT A C TAA G A G AC C C CTCGCTC CTCTCTCGCTTCCACTCAGT T C T C TGT T T C T T A CT T T T T T T T T T T T T T T TCT TTTCTCTCTCTCT TCTCTC G C T C C CT T T T T T T C T T T T T T T T T C T T T T T T C T TTTTTTTTTTTTTTT3767611 1147 0 456 7976 4059152556 023 64 776355140 567 43 75 1 3 4 7 374 0 7 6 5 5 0 3 5 66367531364 913 8 2 2 9 1 7 6 6 9 94 1 4 6 4 4 7 1 3 3 7 7 1 14492561134436603573453922131415161718191021222324252627 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 56 6 6 6 6 6 6 6 6 6 6 6 6 6 62626263636363636363 3 3 3 4 4 4 4 4 42 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 262626262626262626262

[0083] 3620 65 955091932 2 7 5 3 4 4 3 1 2 8 6 3 6 6 6 9 5 1 3 864 9 8 959 18 9 6 9 5 44795056398221455394770982 5 3 3 9 9 1 5 4 3 2 3 33 5 270 5 8 1 5 7 8 2 2 9 6 0 6 2 7 9150533066141153381 38 781449 79 91 TTTTT T T TT TTT T T T T G T T T G T T T TTT T T GT T TT TT TTCAACG GCTCTTTTCCT TGGTAT TCAAGTGAT T T TACCTCC AT T T T TGC T T C C AT T T TAG C TGACAGGAGT TGACACC TCTCTGTCTGAGA CCACCAAG TAAG A C A C G CGCA A G A A C AC CCA AGGTTAAGAAAGAA AAA AC T GAC T A G C C GCGCGCGT C CGC CGG C CGTTC C CGTTC C C C CA A A C AGC C CAGC TT GCCGTA ATC CTT CAAG TC CC G GT G GGGGGGACGGG GGGGG AGGG G GGGGGGGC G G CGGG GG GGGGCGGAGGGTG GGGTGG GGGG G G G G G GGGC T T TG G G G G GTGG G GGG GGGGGGGGG G G G G G G GGGT TGT T TGGTGT TGTG G G G GGT T T T TG G G GGT TGT TGGTG GG G GGT TG G G G GG GGT T C GGGG GT TT T TGTGT TGT TGTGT T T TGT TGTG G GTGT TGT T T T TGT T TC G GTTG C TTC C C T C C C G TATGTGT T T TAT TAT T A TCTATTTATTTTTTTAT TCTTTTCTA T C T TGT TAT TATG AGT TC GAT A T T TACTCTG G TA A AT AGAA ACCGACG AAGACA G AC GAAAG AGAAGTCAGA AAGC AACCC A AGA AGA AGA A CTC A A CACTA AGAAA A A A A A C AC CCTC G C G G G A G C G CA CG G G G C GCGTCGTGC T TGTG G GGT TGT TGT CC G C A A G C GGTGT T C TGCGCC CGTGT T T T T T T CGTGT TGGT TTGTGCTGCTGTTATCTGGTTTGCTTTGTT T TGC G CTGTTTTTTG G GCTCTTTGTTG GCTCTG GATTTCTGGTTTGGTCTATGGTGTCTGTGACGACCC C A C C A A T TTTCGCGCTCGCTTGCTCGGGC A ACACCCCG A T G G C C T AGG T T T T T A A CGGACGTA G AAGC A GT AGT CT T T T T T T T T T T TAT T T T TCTCTCTCTCTCTCTCTA C CTC CTC CT T T C T T T T T T T T T T T T T T T T T T T T TTTTTTT CTTTT CTTTT6753 06865 0 1776739 4350229434 0 1 2 15 83 1 0 3 1 8 5 2 2 0 2 75 4 255 5 874 5 160 9 3 81527830531 7343 55664 3 0 4 4 9 3 6 5 37 1 6 3 3 7 1 7 1 3 1 7 1 4 1 3 3717731519741336732616474849405152535455565758595061 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 96 6 6 6 6 6 6 6 6 6 6 6 6 6 66666666666666666667 7 7 7 7 7 7 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 262626262626262626262

[0084] 71832662285521262374942816505 3 3 2 2 3 9 4 4 8 8 1 4 5 2 3 8 33 4 7 5 1 9 2 5 2 5 1 0 9 12273364672218437238791772767136 8 34 3 5 4 6 7 1 6 8 7 2 3 9 9 8 6 4 5 3 9 0 3 5 0 3 8 7 5 4119763 gacagtcacagaca ac ctct ac ct acaga acacacac ga aca acac gagactctct aca actactct aTacacact tc catctcacactacactac catcct t tac cactactctct t taca tc cacacac catc ctc cacaca tc ctctac caTTTTT C caTaT T TTTTTTTTTGTTC TTTaT T T T TaT T T TT aTaT TTG TT T T TGT TT T TTTTTT TTTTTCTT TTTTTT TT GTGTTTTaTTT TTT TCT GTATATC TTGCACCTT ACA CGGCAGAG A GTTTT C A A TTGAC G G G GTCTT G TCC CGT TGGTTAG CCACG GTT G G G AAC C AC ATA T CAA CTAACAGCAGTTATT A A ACG T A GTAA AAAACAAAAAGAAGACC A CTAA ACA A AGGCAGT C CGTTCGCGGGATTCGG C CGCGC C C C C C CGC T CGT GC CGCGGGGGTGCGGG G C G G G G G GCCGGG GGGGGGGGGGG GGGGGGGTT G GGGGGGGG TG GGGGGGGGGG GGGGGGG GGGGG G G G G G GGG GGGGGGGG G GGTGTGTGGTGGT T C T T TGC T T CGT T TGTGTG GTG GT TGT C T CGTGTGTGTGGGT TGTGTGTGTG GTGTG G GTGTG GTGGTGG GTG G GT TGTG G GTTTGTTTTCT TT T C C G CTT TC A ATCTT G GT TTT T T TC CT TC C CTGTCTTTCTA ATATGT TGT TAT T T T TCT TGTGTAT T TCAT T TA AACT TATCAACAGACCAG G TGAGAAGATAAAAGCGAA AGG G A AAGATAC G G CAC GATG CCTCC A CCAAA AGA AGA A C A AGC CTCCCTA A A A CCA AGA C AACGTTGTGCC GT C TGT TGCGTGCCTGTG C CTC C A G GTATGT TGTCTGTCTCT TGTGTG G G GTT TCTATG GCGG GGTTTCT TCTG G GTGTGGTGTGTGTGGTGGGT TTTATTT TGT T T T TCTTTG GTG G G GGTGGTGTGT TTGGC T GCCTCGCTT C C A A ACT CCGTCACGTGCACGCTCAG A A A TTA CCTCATTTT G C GATCTCGCCCGCT A T T T A T A TT GA CAG GG A T TGT C A GT T TTTCTTTTTC T T T TTC C C C C C C CC T T T T T T T T T T T T TTCC TTC C C CT TT T T T T T T T T T T T T T T T T TCTTTTTTTT574033308443797 08 04 38 31008978 16 2335411898454954 80 02213161018655134430446116346 872 537970457 69293547311540171 3738693771403710408182 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 16 68686868686868686969696969696969 9 9 0 0 0 0 0 0 0 0 0 0 1 12 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2626262727272727272727272727272

[0085] daereiteroCdetoCFgscarg nol_oennotneif56onA42 32252 1880312761829 3 9 9 6821024300410 2 441 3 8 5 7 4 2 4 4 6 4 33428583534641170316757628v82 129 60030811860134628 5684645186813672 0 9 9 3 4 7323224187655398045900 0 5 726 9 8 6 2 5492316683026699951443 31 51314099099868877767475 3ag .e3 3.33.23.23.23.13.13.13.13.13. .33 1.13.13.0 0 0 0 0 0 0 060603.3.3.3.3.3.3.3.3.3.3 ffe 1Fhtmu TGT T T TlGTCCCCC ATC G TT TCCCC C CCCATC A A C T C CTC C C T C C ATT AGCCAC Ait gcACCCCCTTGTG G CCCCCGC GAC G Cini niCA ACACAA AAGCCT ACA A A A AATAC A A AAC CATTCCAGC C C CGCGTCT T C C CGCGCGT T C C C T TTTTT CCif s dtu G GGGG GG GTTT TAGGGGG G GTGTGGGG GGTA C GTAGFg eodoproLsagc o Gnc tia eGG GGGGGG G GTGG G G G G GGsTGGTGTG G GTGTGCG GTG GTGTGTGG G G G G G GTG GGCG G G G GC CGGGGTGCGdn dodeecTG GTTTGTGG G GTGGTGG G G G GTGTGTGTGG GTCTTCT T TTTTTTTTTCT T T T TTATT TTCT TGTTT T T T TTTG GTCTGATCTeeTATCT T TGT T TATATTTGT T T T TTTuGGATAAG A GCAGA A A A A G G G A A A G G AAAGAGA Amie e dqtd A A ACst cnsCTA A AAATCGCGAGAAACCGAGATCCCA CA A AGAAnesGTGTG C A G G G C C G G G CE nTG G C CCCCC G GCG GAG;a eoyt uq it dic G GTa T TGTTGTTGTTGTTGC TTGTGTTGT TTGTGTTGTGT C C T T T TTGTGTGTGTGTGTGTGTTGT TTGTGTtueui sti lmt oGnGGAGC C GAGCGCTAAGGATT CAATGC C G G CTGTATTATAGC C C G G G G GGATATATTATATAGTGGTTC TAATATa lAsnaNb iouDusmCaTCTTC C C C C CTTTTTTTTTTTTACTG C C C C C CCTTTTTTTTTTTTTG C C C CCTTTTTTTTTGCTCCTGCTCTTTg doivhi D 2t I32rdn-232192152332 0 6 9 6 3 2 2 4 1 5 5 2 2 0 6 5 6 1 257164799494937415242479389536265 5 1 6 9n3 3 3 3 2 3 2 7 6 6 4 2 2 1 4 7 6 2 2 29797879734oi5h org6caeA eD.r4of 213714715716717718 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6717172727272727272727272737373737373 3el stDI 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 27272bnau QoE OTS N

[0086] 246215424273499 8 4 727 4 919 5 1 3 9 7 8 8 9 4 7 9 8 5 9 3 4 2 5 10 4 7 0 9 5 65111297493013502874499897 4 7 1 6 0 6 4 8 5 5 5 92 5 0 7 9 7 5 5 5 5 5 891 0 279 4 8 6 3 078812824749021818629228853 GTT T G T TC CT T T T TTT G TCTTT TT TTT TCTCT TT CT T TTTAATGT T TGCA CT A CTGT T T T TCC T CTCCAAT GT T TAT C T GCTT CTCCTGACGT TCCCT GTGATT TT TCTAAAGT TTC TTGTACCTT TTCTACCAACC CC GG G CAGCGTGGCG A C T G GA CCGA C TAGT A GG CTTC CC A ACTAGTC A A A A ATC C T T CGC C C CAAC AAAGC T CGCT CA A AGC C CA ATT ATT A AG GC C T C T CGC TA A ATAG CT C C CTT CGGGG G CG GGTCTGG GGGGGGTT GTGGGG GG GGT G TG GT GGGGG T GGGG GGGGGG GGGTGG GGGG GGGG GGGGGGGGGG GGGGGGGGGG GTGGGCGGGGTGG GGGGGGCGGTGT CG G G GTGT TG G G G GTG G G GGTG GT TGTGT TGT TGTGT C TGTGT TGGT T T T T TGGT TGTGT T TTGCT T TGT TGT TGT TGTGTGT TGTGT T TG GTGTG GT T TGT TGTG GTTT TTCTC T T C G C TTC A G T CTT C T T GTT G ATC T G GTC A A CTT CATATAT TATAT T T TGT TGT TAT T TGT TGTGT T T T TAT T T T T T T TGAAC CAC C TACG GCGACGAGAAGGAT AA G ACGCG GAA A ACA A AC A A C C A C CGC A CGACC C ACC A A AACTC CCC CAC ATCGA CAACCGC A C C G C CCC C CCC A G C C C C CACGT T TC G G CTG C G CTC G C G G C GGTG GTGTGGCGT TGT TGT TGT T TGT TGTGT T TGTGT T T T TGT T TTGT T T T T TGT TGTG GT TG GTGT TGTGT TGT TGTGTGTGTG GTGCTGT G G C G ATTAG GTG T GC T TTT GTT C GTCTT TTC A G G G C G G G T TTT ATT TTTAGTG G A T T G TAA ATG A G T T T CAT GTT T CTA A A ATAG CAC GCCAC G CTCACTCACACTC ATC CGCT A A A AACCA GGT G T TT T T T T T T T T T T T T T T T T TCTCTCTCTCT TCT TCTCT TCTC C G CC T T C T T C C T T T T T T C T C T T T T T T C T C T T C TTTTTTTTT6835256121212359 708332839 1570263025 2 5 0 2 9 2 1 1 3 9 110 1 54 7 2 8 3 4 7 4 745 4 5 7 646 4 8 4349215852677930 3 5 5 819 8 2 96 1 3 6 3 2 6 6 3 4 2 1 6 4 6 1 4 3 2 2 2 6 2866293763434863473839304142434445464748494051 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 07 7 7 7 7 7 7 7 7 7 7 7 7 7575757575757575757676 6 6 6 6 6 6 6 6 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 272727272727272727272

[0087] 2263262752515192606 4 8 8 1 6 4 3 9 3 1 3 4 2 3 8 3 9 7 9 5 1 8 4 38 8 0 9 2 9 2 7 8372498745729101754150 6 4 5 8 7 8 4 5 1 6 1 9 7 49 3 9 2 6 3 0 6 0 1 6 6 5 3 3 6 1 8 5993178896825884207030959471374 TT TTT TCT T T T G T TTTTG GTG GCT T T T G T T TT TT T TTTTTCAT TGTCAT TTT T TAA TT T T TAT TGT TGT T T T TACCCGTT GC CAA TCT AAG GTC A G TTCTACT TGG CTGTCT T T TGTAC T TAGAACATCACCACAAT GTAA T TGA AA CC GATCCTA AA ACAA T ACC A TC AT T C CGTCA A A C ACAA ACTGT ACC TTC ACAA A T A A ATCA A A ACAG GC C TG GGG GGG GC C CGTGTAGG GGGTC C CGTGGGG GGTTCTTGTGTTCTT C C C CGT G G G GTGTC CAG GC T C C CGG GCGTCG GGGGGGGTGG G G GGGG G G GG GGG G G G G GGGGGG GGG GGGG G GGGG G GGGTG G G GTG G GTG GGGG GTG G GTG G G GGGG G GTG GTG G G G G GTGGTGTTGT CTGTGTGT TTGTGTGCTGT T TTG GCTG GTGCTGTGTTGCTGC T T T TTG GTG GTGTGTTG GTTGTTGT TTG GTGTTGT TGCTCATT G T A C C A C CTTTT GTAT T T TAGAG ACAT T TCA ATGT T T T TC C C T ATC TTT C C CAAAACA A GTAAT TCA ATA GATCAT T T T TAA G A ATGT TCA A CTTG ATC C G GGA AT T T TGGTA A AT T TTCG GTGACCA CTC C CAC C A C CTCAC A C C A C CCCCCAC C CAA CACAC CTC AACTG C C C CTC CGTGTGT CGGT TG C C C C G CGT C TC G CCC C CCC C CGT T T TGGT TGGCGC T T TGTCGC CC G C C C CGT T T C T TC G CGT TGTT T TGT TGTGT TGTGTGT T TGT T T TG GTGT T TG GTGTG GTGT TGGTG GTC G GTATATATATAGTCCGCGCCG C C A G G G G CTT CTT G A GTT A ATTTT C C GTTAT G A G GTT T GTGTA G T A G GTA A C ACC G T G GC C C C TGCACGCTC CACTCCCCC GATGC G ACTT A C GGT C A A G G T TT T T T T T T T T T T T T T T T T T T TCTCTCTCT TCTCTCTATCTC C C CT T T T C T T T T C T T T T C C T C C C T T T T C T T T T TTTTTTTTT5957333197085948 15719 323029106310 0 933 7 9 5 2 7 9 5 9 9 3 31524262916631733 413765 324612386669138964965 764 786103341 1 4 3 9 9 9 7 921865492835673310414 417273747576777879708182838485 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 47 7 7 7 7 7 7 7 7 7 7 7 7 7878787878797979797979 9 9 9 9 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 272727272728282828282

[0088] 64 92 81364350489 3 6 3 465 5 6 8 3 7 1 718 4 4 6 2 4 4 2 7 9 6 9 5 51 9 2 2 8 0068669581459008803026057617 5 5 0 8 5 2 2 9 3 4 31 668 9 4 2 9 9 9 0 4 8 611 0 6 5 5 1 0 295316425032501794982453658 TTGTT T TCG T T T G G TTG GT CT T TTT T GCTT T TT T T G G T GTGT T TGTTCTGC GGTTTATAT TATCCT TGA T CGTATGTTGTTTA ATTGTAT T TGCGTC G CTAACG CG A CCTTCTTCT T T TGT C TCGAG C T TTCA A A ATATCTGAAAGC AAACC TC GC ATTTCG G C C GACGT C CTA A ACA ACTTT T C G G TTAAGCACACA ACATCCACAC ACTGCGC C CGTTTTC C C T TT GT T TTT CGCGC C TTTG G GCGGC T T C TGGGG GGG C CGGG G TC GTCTATCTGGGG GGATGG G G G GG T TCGGTCGGGGG G G G GGGGGCGG G G G GGGGGGGGGG G G G G G G GGGGGG G GTG G G G G GCG G G G GTGTG G GTG G G GTG G G G GTGTGTG GTG G G G GGTTGT TGTGTGTTGCTGTGT T T TTGTG GTGTGTGT TTGTGTGC TTG GTTG GT T TTG GTGTTGTGTGTGTTGTGT T C T CTG GTGTGTGTTC G T C C CTGTAT T TGTATA C T C CAT T T T TCATC T ATGT TATA ATGGTGG C C C T CAT T T T T T TAT TATGTC CGTAT TC A T T CGT T T T TGATG ACAGCGCCCACGA G G ACACCCACTCGAAAACCGCAA ACTCGG GAACGG GATCCCGAACCGAGAGAACAAATA ACCCCA ACGAGCTCTC C CGTGT TTG GTCGTCGTC C C C G G C CGT T T CGCGTGCGTC C G C G C C G CGCGT T T T T T C TG G G CGTGT TGTGGTC C CGTGC TG CGT TGCAGT T T T TGTGTGT T T T T T TG GTG GTG GTGT TGT T T T TGT TGTTGTAGCAGGGG G C G CAC G T C CT T T TAT C T C T C T C G G G G C G C GTTC TCGTCTCACGCTGATT G TGACTCACCAGTG GGTCTGGTGCTGTA C T C C AGTCT A A A TGCTG T G A G A TGT A T G G C TGAT GGA TGTTTTTTTTTTCTCTTTTTTTCTCTTTCTCTCTTTCTTCTTCTTCTTTTCTCCTCTTCTTCTTCTTCTTTTCTCCTTTC7379251812403138 65269661808184855797 2 3 0 3 4 1 3 074 5 1 6 2 34 3 5 7 4 8 8 5 746 5 9 1 4 4 5 5 39597382879844115819 0 7 4 7 5 94 1 4 3 1 6 6 2 2 6 7 4 6 6 6 6 4 3 1 3 3 7 6 4 21431035666714650607080900111213141516171819 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 88 8 8 8 8 8 8 8 8 8 8 8 8 8182828282828282828282 3 3 3 3 3 3 3 3 32 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 282828282828282828282

[0089] 9760 52 689697519 4 6 1 4 652 3 3 1 4 6 9 1 289 3 7 6 5 8 5 3 4 4 3 27 1 0 5 1 59123655957092456770429100 1 1 4 7 3 1 6 2 7 2 9 69 3 645 2 5 5 0 8 6 8 1 2 219 9 4 1 6 98199 39 5034412780677414484899 TT T TCT TTTT GTG G T TTGCTTT T TTG T T T TTT T T T G T GAAT TTTATAGACTT CTGGATAC TT T TA GC C TTGTG CT TGCTCTTAGTTTGTGGAT T TCGTTTAACGTATT TCC AT T T TCAAG GTAAG T G G T GCA A A ACA ACCAC GGCAA TGT GCCC ACT C A A AC GT AATAG T T CAT G A C C GGT C CAC GGCA ACA ACC A ACACACA A A A T AGGC CGGGGCGG GCGGGGGGGTGTGGTGTTGTC CGG GTGGGT TTCT GCGGGGCGGGGT CGTTGGGGGGGC C C C TGGGG GGG TCCTAG TGGG G G GTG G G GG GTG GG G G G G GGGGTGTG GTGCG G G GGTGG G G G G G G G G G GGGGGGGGGTGTGCG GTG G G GTGCG G GTG G G G G GTG GGT TGTGTG GCGG GCGT TG GCGT TGTGG GT TGGTGTGT TGTGT TTGAT TGCT TGAT TGTATCTCTCTGTGT TGTGCT TGTT TCTCTCTGTT TTTGTTTGT TGT TG GCT TTT ATTT TC G ATCTCTC A T C T A TAT T TGTGTATA ATAT T TGTATGT TATAATAT TGA TAT T T T TAT TGAAG GGAC G G T G CAAG GG CAGAC A A G GAC GCAAAAG AAAT AA AAGCGCCC A C A A CTC C C G C CA C CACTC C CAC A C A A A A C C C A CGC A A CTCACGTGTGTGTGTG GGT TG CTCGTGTGGTC C CGT T TCGCC G CGT T TG G G G C CGT T T T TGTCGTG C C G A CGTGTGT T T CC CGT TTGTTGTGTATGTCTGT T T T TG GT T TG GT TGTGTGTGT T T T T TG GTGT TG GTATATAACTAGG T GGT G GG GTT ACTT G C GTT G C A C G T G A A G CTC G A GTGGTC C G GTATT G A G T ATA A G G G A T T TC GAG TCTC C C C CACTC GAC C GACTCGC A CACACCCT AGC G A T A T C GGT ATTTTTTTTTTTTTTTTTCTTTCTTTTTTTTTCTCTTTTTCTTCTTTTCCTCTTCTTCTTCTTCTTCTTCTTTTCCTTTC17585371001850 36056431912187300931 7 113 9 712 3 0 1 2 3 3754 5 6 1 5 3 5 138 4 5 4 8 5 4 8 8155549 03 747970 59 3 5 4 4 3 7 734 62 2 2 3 2 1 2 6 2 6 6 3 3 1 6 6 2 3 2 2 7 333145354229366669304142434445464748494051525354 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 28 8 8 8 8 8 8 8 8 8 8 8 8 8 85858585858586868686 6 6 6 6 6 6 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 282828282828282828282

[0090] 37262363309695851 7 8 7 7 6 4 911 4 2 3 3 7 1 7 7 7 7 9 7 5 6 8 1 94 9 0 4 3 3 3 689936966915856274904534 7 7 0 7 6 8 8 6 0 1 8 2 92 1 8 8 6 2 8 5 8 3 7 5 9 0 7 9 495 5 47262292525806523559411901398 TT T CT T TTGTTTG T T G G T G TTT G GCT TTT T TTT GTTCCTTGT TTT TCTGTC AT T T T T TAT T T T TGTATTT TATGT TT CTGT GT CCCGAC CGTCG TACGAG T TCAA G C G CTTC TTCGC ATAG CGTCAT GG A C TC AATA A A A CCGTT ACTT A AG CACC ACCAGCGCGC CAATCCACC CAATAT TT C AGT A AT C C C A A GACACA A A ACA T ACACGCCGGT CTGC CGT T CGG GGGTAT GGGTGTC C T TAGGG TGTC T C C T TAGGTTG G TGTT CCT GGGC C CGG GGGGGC TGG T GCCTG C GG TGG CGG GGGG GGTGGG G G G GGTGGGGGGGG GGG G G GGGGG GCGG GGTGG G G G G G GGGCGTGGGG GCG G GGGG GTG G G G G G G G GCGTG GGT T TGT TGGTGC TGG GT T CGT TGT T TGT TGTGT TGT TGTG GT TTG GT TGT T T TGT T TGTG GT TGT TGTG GT TGT T TGTGT TGT T TG GGT TTGTTTTTT G GGA A AT T TCTAG GTGTA C CGAT TAA ATT TTAGTGATCTCTTTT C CTAAGA AAAT TC T T A T GTA A C G T CGG AT T TGA A ATCAT TGA AT T T T T T TATAG ATCTCAA GAACGAAAAAT TGA AATGCCC AAC C A CCC C A A CTC C AAC ACCCC CAC A CTA C C A A ATCCCTCGTCCGTC C G CTG G GT TGTGCC CGT TG GGTGTC C C G C G CCC CGTGT CGTGT T T T TCGTC G CCC G C C G GGT TGTGT T TGTGT TG C CGT T TTTGTTTTGGTCTGTGTGCTCTGTGTGTGGTCTCTGCTGGTGCTGAT T TGA GT TG GT TGTGTGTGTTG CAT T T TAC G G A C G G C A A G CCTCTCAGTC G G ACACTCTCCA A A TGTTGCCCAT A CGGCTCAAATT G C TGACTTA T AGGCGTG A C A G G A GCT C T T T T T AG T AAC A TCTTATTTTTTTTTTTTCTCTTTTTTTTTTTCTCTTTCCTCTTTTCTCTCCTCTTCTTCTTCTTCTTCTTTTC CCTTTTTC7571 0 5 21324 674138153901845278 09 80903833010560763926632692 6 6 4 2 7 1 2 2 3 1 5 0 3 67537735475101453 7 1 9 7 8 9 26 4 3 4 4 6 6 2 7 4 4 6 7 2 7 3 2 6 6 6 4 3 3442434348713528637475767778797081828384858687 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 68 8 8 8 8 8 8 8 8 8 8 8 8 8888888989898989898989 9 9 0 0 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 282828292929292929292

[0091] 642891453193332 4 7 389 7 1 6 2 8 8 8 469 7 9 8 5 6 7 9 1 6 5 8 4 37 4 3 0 8 9 03880675522634481612266678 3 6 7 4 9 6 5 6 8 9 7 70 6 9 5 5 7 1 2 8 7 7 782 2 6 5 5 1 1 3 41 24752253365722723491010081 GTTGT TT TG G GTGCGTTT T G T TTG T T TTG TT TT T TTT T T TTTC ATGGC GGT TGTTCTGTGTTCTCTTT TTAT T T TCC G C C TT TTG G AC A A C C AG CT TTC TTATCCG A GCT TTCTGTCCT T TAGATCCTGC GGTCCA ACTT GTC CCAGCATTCAACTTG AGC ATAACCAGCC TAA GCT TCAC A GCCA A AC C TTT T A CCAG T TACAT A A A A A A ACTTCCG GGTGTTTTTTTTTTCTC T T C C C T CCG TTT GTTGGG G TTGGTGGC CGG GTGT CGGGGTC GTAGCGGCGGC C CGG G GCGG CTGTGGGG G GC C GCG GTGG GCG GGGGGGGGG G G GG GGGGGG G G G G G G G G G G GGGGGG GAG GT CG GTG GGGG G G GTG GTG G GTG GTG G GTG G G G G GTGTGTGT CTGC TTG G GTGTTG GCTGTTGT T C TTG G GCTGTGT TGTGTTGTTGTGCTGTGC TTGTGTGTTGT T TTGTG GTTGCTGTTTATGTACATGTCTATCTTTTTTTTG GA A ATATGA C ATTC CTAA AT TC A C C CGAGAT T T T TT TATGA A ACGGATT A CGAT T TT G A T T A CTA G CTTGAGGTGT TGATGT TGATGTGAT T T T TGG A A G ATAACCA A AGCCC C A ACC C ATCTA CAC A C A A C A C C C C AGAGATCGA AACCG G GTC C C G GCTC CTC G C G CCC GTC GTG C G CTCTC C G G G C G G CGTGTGTGC C TGTGC T T TGTGCGGT TGTGG GTGTGTGT T TGT TGCTGTGTGTCTGTGCTGTTGCTCTGGT TGTGTG GTGT T T TGT T T T T T T TG GTGTGTATAATGTATTTATTTTT CT TACTCC C T T C C A CGG A A T G T G CC C G C GGG A A G TC C G GTTTC ATC C TAG GTG G A T A T G ACTC C C C G C G G C GTTTCTCACATACGC CGCTCCCAGG T T T T C T A CTCTTTTTCTCTCTCTCTTTTTTTCTTTTTTTCTTTTTCTTTTTCTTTTCCTGTTCTTCTTCTTCTTCTTCTTCTTTTC160052050264336951946679691039042197874 6 6 0 2 5 7 1 5 1 3 0 1 1 66 4 4 9 8 5 8 6 8 5 4 4 3 5 6 7 9 2 4628311647634840351343 6 6 2 86 2 4 7 6 6 6 7 7 3 6 6 4 4 1 6 1 1 6 1 4 3 3 6 1 6 4 4 4010301435670809001112131415161718191021 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 09 9 9 9 9 9 9 9 9 9 9 9 9 9292929292929292929393 3 3 3 3 3 3 3 3 42 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 292929292929292929292

[0092] 93357054668990531 3 3 9 1 9 2 9 3 3 9 3 7 4 5 6 5 9 4 4 6 8 6 295 28 9 2 6 6 8 0 747201402013836280385924 9 0 6 8 7 4 3 9 5 7 9 8 40 4 1 0 0 1 4 0 9 0 9 4 9 8 7 6 1 3 564444373306365361488674723 88 39 TT TCT T T G T T G T T TTTCG T T G G T T TC TT T G T T T TTG G GCTAATTTCGT TTGACT T TCTTA TTCA CTGT TGTGTA G CTCTT T T T TGGGAG A T GT TC GTCTT T T TGCGC GACT TTCGT T T TCT T C C AACG A C A ACA GAC T AC GCCAA A C A A T A A ACAT T T TCACT CCGT GCT T TAT C G CTAC CTACCCA CAT A A ATC ACACA T A A A ACAC TATGC C CGTTCGC TTC CGCCT TGCGTTT C C C TG GC TTC C C C C TTT TGG GGG G GGGGGGGGG T TC G G CTAG G GGTG GGGCG GGGGG GCTATGGGG G G G G G GGGGGGTGG G G G GGGGGGCGG G G GGGG GGGGG GGGT GGG G GTG G G G G GTG G G GTG GTG G G G G GTGTG G G G G GGGGCG GGT T TGGTGT CGT TGT C CGGTGGTGT T T TG GT CGT T TGT TGCGCTG GT T T TGT TGTGT TGTGT T T T TG GTGTGT TGT TGTGT TG GT TGGT TT C A TGT T TATC C C C T C CTT C T T TATAT TAT T TGT T T TCTT C TTT G G T C T T ATTTT CATGTAAT T T T T TGT T TAT T T T T TCTTAT TAA AGG GAC CACACAA AA G G GAGA ATAGAAG GT GA G GTG AAACAAA GGC A A A A C C A A AGCCC C A A A ATC C AAA AAA C CACAC ACCTA CCCTCGTGTGTGCG CTG G G GT TCGCA G G C C CGTGT TGT T TG G GGT TG C C G G G G CGTGGT T TGT C T T TC C C A CCC GGCGTGTGT T T CCGTCGTGCTGCTCTCTGGTCTTTATGT TG GT T T T TG GT TG G GTGT T T TGTGTGT T TTT AG T CTC G C A G GTT A GTCTC ATC G A G G G CTC G GTCCTTCTACTT G GCATTCGCCT T G A C AGACGCACTCTTCT T GGGCACTAGTA A T T C T A C G A T G T TCC C A TTA A G GTT C A T A G ACGGT T T T T T T T T T T T T T T T T TCTCTCT TCTCTCT TCTCTCTC C ATAT T T T C T T C T T T T C C T T C C T T T C T T T C T T TTTTTTT CTT65 2 06 1 73 51200933178 13 86310723551865415558795551963450 2 1 7 5 5 1 9 3 0 2 2 5 6 69797060579617849 7 7 0 764 7 3 6 71 1 4 7 1 6 2 3 3 4 6 6 3 2 7 7 3 3 1 7 371462413528197664614243444546474849405152535455 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 49 9 9 9 9 9 9 9 9 9 9 9 9 9595959595969696969696 6 6 6 6 7 7 7 7 72 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 292929292929292929292

[0093] 4576 54 721 4162627 6 6 1 760 5 2 3 5 1 3 4 4 277 5 6 7 8 6 8 8 5 4 26 9 799 4 9411456514314245161268240940 1 2 5 6 5 3 0 5 9 23 1 83645 5 8 0 2 5 7 3 3 638 8 0 1 1 2 9 420 30 94197182698444252584 TC T T TTT T T G T T TTT T T T T G T TTT TTT T T TTTCG T G T GTTGGTTTGGT TAGAATTCTTATCTTTATTT T T T TGATCT T TTT TCC C TGA G A G CTCCTCTCTCTGCCT TGC CT T T T T TCT A TCA CAGAA T CCA A AGAGAGAA G A A A CCTTGTC ACCTACGTA CGGGACGG GA GCT GGGC CGCGC CGCCGTATCA AGCGCA A A A AAGCC A ACAGC C C C T C CAC CATAA A AAGC C C C CTTAGCC C ATTC ATCTC TTC TGGGG G GGG G G G G G GGGG G GGT GGGGGGGGG G G G T GGTAGGAGGTCGG G GGTG GG G G G G G G G GGGGGGGGG GGG GG GGGGGGAGGTGG G G G GTGTG G GTGCGTG GTG G G G G G G GGGTGGGG G G G G G GCG G G GGTTGGTGTGT TTGTC C GTGTTGTTGTGTTGTGTTGTTGT T TTGTG GC T TGTG GTTGTG GTTGT T T T T T TTG G GTGTG GTG GT CTGTGT CTGTGTTG CTATC A C G CTT ATC C CTC TTTTC G CTT CTC C C T C CGT TGA GT TATA ATATATGT T T T T T TTT TATAT T T T T T T TAT TAT TAAAGCGGACACACAGAACAAGAAAAACG G A ACACACAAGA A ACCCGCCACT AAAG A G G AATCTCTCA TA ACACCCAAAACAACCCACTC G CTC G C GTG G G CTC C G C C C CCTC G G C C CAGCTC C G C CTC CGTTGTGTGTGTGGTGT TGT T T T T TGT TGT T T T TGT T TGTGGTGCGGTGGATTTGTATGTGTGTGTGT TG GTG GTG GT TGTGTG GTG GTGTGT T T T T TTA TG C A ATT TTT GTT C CTT G ATC CTTTT C C C G G GCG CCCCCAACCACCG CCTCACGT G C G A G C T TGACTCACGCCCTCTCACTA G T T C A G G T GGCCGCT G A T T T T AG ACC TGTCTA GACGTT T T T T T T T T T T T T T T T T T TCTCTCTCTCTCTCT TCTGT TC G C GT T T T T T T C T T T T T T T T C T T T T T T T T T C T T CTTTTTTTT790710313675736377 7577227 57318653 5 3 2 1 90 05 6 0 5 4 0 5 2 81 0 7 1 0 1 8 9 4 036 4 6 744 5 5369351196655 2464 7 5 0 2 5 8 7 6 94 3 3 3 3 4 3 7 2 3 1 1 3 2 6 1 1 1 3 3 401763386977346034657677787970818283848586878889 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 89 9 9 9 9 9 9 9 9 9 9 9 9 9899999999999999999999 0 0 0 0 0 0 0 0 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 292030303030303030303

[0094] 6721896239 35 541 4 285 3 3 2 9 9 8 3 5 6 6 4 2 6 3 6 1 4 6 7 474 3 10 2 2 2 2 40266659559431071608829779 0 8 8 6 2 8 0 0 8 8 4 08 3 4 2 9 575 7 7 2 924 9 0 2 8 6 2 8 83125368648283122543420 51 8775 TT CCG GTGTGTTTT G TGTGT TT GT TGTGTT TTTTT TTTTT TGTGTT TTT TATG TTTGTGTGTTT T TTTGTGCTGTTTTTC TT C TCCAT CCGCAT T GTGA CCGA T C GACTTC CC CCC C GTC G A GCAT AC G T G AGT G T G A TC TT C T C A A C A C ACACAT C C T C ACA ACA A ACAG G GTT GGCACA ATC A AC ACCC CAGCTAGGTTT CCA CTAGAGT T TTTTC C TTCGTT G G GCGCGCG G GC C T CGGT C T C TTTCT C CGTCTGG AGGGGG G C G G GGG GGGG G GGGG TG GTTG TTGCTCT G GGGG G G G G G G G G G G GGGG G G G GTG G G GGC T TG G G G GGTGGT TGC TGCGGTGGTGGTG GGT TGGTG GGT TGG GGGAGG G GGGTG G G G G GG GGGG GAGTGT T C TGTG G G G G GGGGTGGGGGGGT C T CGTGT T TTGCT T T TGT TGT T T T T TGT T TGT T T TGTGTGT T T TGTGTGT TG G GTT C T CTT T T C CTG CTG C G A T G GTG T C C C A A T CTT T CTCTTTTAT T TAAT T TATA ATGATGT T T T TGGT T T T TGTGT T T T TATAT T TGATAAG AAGGGA G A A G GA GGGCAGG GGAG A AG AACA A AA CA A AAGC C C C A A C A C C A ACA A A A A A CGCAACC A C CCAGCAC A CT TATCTC C C C C G C C G G G G C C C C C G CCGCGCGC CG GG GT T CGT C TA G G G C G GT TA CTC A CG G GTGTGT T TGT T TGTGT T C TG GT C T CGGT T TTGTCGTAT TGG GTGTT TCTTTGTGTGTGTGT TGTGT T TGTGTGTGT TGTGCTGTGT TCTG G GCT T TAT ACAG T C G C C G G C T C A C C TGT C CCACAACCCGG AGTCTCCG GGCCGA A T G A T T G A G C T TCGCCCACTCTCACACTCC T A A TT G GGA A CT TGG TG AGT TGAAGTATCATAT T T T T T T T T T T T T T T T TCTCTCTCT TCTCT TCT TCT T TA C CT T C C C T T C T C T T T T T T T T T T T T C T T C T C T C CTTTTTT2746660093 763185897 70510 1622514 3090 5 0 4 5 0 5 2 057 1 0 2 76 6 7 7 5 134 5 1 5 599 5 634 4 7 53903284745974 3 7 434 7 4 3 5 93 6 6 6 6 4 6 3 6 2 2 4 2 1 2 4 3 1 6 13376935697768644739001112131415161718191021222324 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 20 0 0 0 0 0 0 0 0 0 0 0 0 0 02020202020203030303 3 3 3 3 3 3 4 4 43 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 303030303030303030303

[0095] 463310679382125 9 9 5 984 8 666 3 2 1 8 8 5 4 8 2 6 8 9 7 4 5 7 6 80 1 0 9 0 7 478208508857989589086345 2 4 5 8 9 9 6 2 1 9 0 8 38 1 0 6 7 8 5 0 4 4 3 9 971 1 548 2 2 89263743677674864641463424303 TTT G G T T T G G T T T T T GTT T T G TTTGTCT T TAT T T T T T T TTTGTTT T T T TGGTTATA TTTTTTCTC TTTTCTTGT TGC GTT TTTGAGAAGTCG G CCAC AGGGCACTTCA A T CT CT C GTT G C C TCAAACATATG G C G AGTTGTCA T CCT G C G CGA C C A AAT A G TGC TT A A A C CTTA A A ACA AT T G A GCTCT ACA A A T A ACACACA A ACACA ACA ACTGGGG GTC C C TTG TTGGGGCTC C CTG GGG GGGTGTTGC C C TGGGG GGTCAGGGGGGGC C CGG GGG GGGGCGGGGCGG GTG GTAGG GTG GG G GGGGGT CGCG G G GGGTGG GGGG G G G GGGG G G G G GGGG G GCG G G GTG GTGTG G G G G GTGTGTG G G GG G G G GTG G GTG GGTGCTGTTGTGT T TTG GTGTG GT TT T TG GTTGTGTTGTGTGT T T CTGTGTGTGTTGTGTGTGT T TTGTGTG GTT TGTTGTGTTG GTTGTTTGTCTTATT G T AAG AT T T TATT T C A C C G C G T C C TATAT T T T T TATGT T TATATATTATTATT T A GAT T T TC C C T AGTATATAT TAGTAAAGAAAAA G ACG T A AA GCA GCGC GG GG A A G G GATAAAC G G A AAAG GTGGTGCCCAC C A CTC CAC CGA CCCA CCC A C C A A A C A A A A C C A A ATG GCC C C G CGT TC CGT TGCGGTGTC CGT TGGT CG C C G CGT TCGT T TGTGGTGGTG C G G G G C CGTGTGT T TGT TGTG G GGT TGTTTATTCT TGT T T T TGT TGT TGTG GT T T T T T TGTGT TGT TGT TGTTATAGTTTC C C TAATTTACAACCC C T GTC AAATGAATGTT AT TTC C G G G G A G C C GTGC C T C ACA A G A G A A TTAGGGATCGACTCTC G G C C C G G C C C CTC AACACTCTCCCCCTCCCTCT T G T T G A C ATTTTTCTCTTTTTTTTTCTTTTTTTTTTTCTTTTTTTATTTTTTTTTTTTCTTCTTCTTCTTCTTCTTCTTCTTTTC037246363039526387715961513753502308925 3 3 7 6 9 7 0 1 4 106 7 54 4 9 6 5 1 6 7 7 5 5 5 3 0 5 7 8 1 41770594159728323498 609 7 9 54 4 7 6 4 1 1 7 6 4 3 4 4 1 6 3 3 1 3 6 3 2 4 2 4 4 4 334246392773444546474849405152535455565758 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 60 0 0 0 0 0 0 0 0 0 0 0 0 0 05050606060606060606 6 6 7 7 7 7 7 7 73 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 303030303030303030303

[0096] 83 75064892 1 3 476 5 9 23031 5 7 7 9 5 5 6 920 7 5 4 8 1 885 5 2 9 21 2480486017682447536 44 73046 9695 1969 229861145595109282321511 22 85877 6 4 0 6 5 3 2267603279 92 96069491 TTT T G GC TGTT T T T T G T T G T T T G T T T G TTTT T T TGT CGG TTTCTCC C A CTGT T T T T TCCGGTC ACGTACAT TAG TTCAT TCT GTCCTAGT TTT CTTCT T TTC T G GT T T TGT TATC C TA G ACA T CTGATACATCAG TAGCCCT AGACA T CAA AGACAACTTACCT G G ATT A TCA A G G GA GTCAT GG GC C T TTT CGTTC C C C C TTCA C A A A T AGC TTC C C TTCAGCA C A AGC TTC CAGC CTGGTT ATCAAT AGC T CGG G TT ATG AG GGGGG GGC GGGCGGGGGGT G GGGGG GTATGG TCGGGGGGTGGGGGGCGG G GGGT T T TG G GG G GGGC TG G GGGGGGGG G G G G G G G GGGGGGG G GCGGGGGG GCGT T T T TGCGGTG GGTGCG G G GGT T TGGTGGTGGTG G G GGT CGT TGGTG G GGGT C TG G GGT C TTGTGTGT TGT T TG GTGTGT T T T TGT T T T T TGTGT T TGTGTG GTGTTC A A AAT T T TA A CTAT TT G CTC G AATAT T T T T TC C C C C G AATATATAT T T TG ATAT TC T C G C CTC CTAT TAT A TAT T TA TTATTCTGGTA AT GAG CA GTAAA GG A G CGTGAGAGATACG CGATAGG ATAAGCAC C ATC A CCC AACGC A C A C C CAC A A ATC CACGC A CTC ATCCCTCGTC CTGT TG C G CCTGTGCTGC T CC C G C C G CTGTG GT TTG GT T T TTGTG G GTG CTGT CC C C GTG GTTGTTGT CG ATGTGT TC CTGTGT TC C G C C GCC C CTGTGT TTG GTTGCTGT T T TTGTGTG GTTGATA C A TAA A GACTTT GTT A CTCTC C GTT GACTA GTA A A A A TAA A TG G A G T G C GTC G A C T CTT GTTGT A T GTG G G GTA T T ACACG C G CCCCTC C G ATC CTCCCTCTCTC AGCCC GG C ACT G TGT A GAT T TTAT T T T T T T T T T T T T T T T TCTCTCT TCTCTCT TCTCTCTGTC CTCT T T C T C T C T T T T T C T T C T T T C T T T C T T TTT CTTTT CTT5510910251645871115198003535 5215 0 2 0 47461 0 0 7 3 556 7 57 1 5 7 9 7 3 8 5 1 3 5 5 7 1959760011949 43 23 34 1 4 0 1 9 813 9 0 81 3 4 6 7 6 4 6 4 3 4 4 4 7 1 6 4 3 1 7 186546293565653867377879708182838485868788898091 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 00 0 0 0 0 0 0 0 0 0 0 0 0 0909090909090909090010 0 0 0 0 0 0 0 0 13 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 313131313131313131313

[0097] 439075284517102 4 1 4 7 8 269 3 9 5 1 7 6 1 8 575 6 5 8 6 4 7 9 4 23 5 2 5 6 1 125891300016559400052622 7 9 5 7 1 4 4 0 0 4 7 3 11 4 2 2 0 7 5 3 2 7 7 4 8 1 127 3 1 57972620350 91 842769478357253905 TTTC T TTTT TCTTT G G T G TTT T T T T TTT TT CG T G T T TGTTT TTCCA CAACCT TGGC GT T TTTCGT TTTAT TCC AT TCG TT T T TTT CGTCTT TCT TCCCCC GCTCCGTGT T T T T TTTTG TAT C CA AAGACAC A G GAT AAG ACCT AC ACA GGT GCA A G G A C G A C GA CA ACAAGGGT A GGCA A ATCA AGC CA C C A T A A A A A A A ACA ACAC CTTA C A ACAGGC C T CGGC TTTTCGTTCGC C C CGC CGCG G TTTC T CGCGGGGCG G GGGGGTG GGC A G C GG GGGGGGGGGGGGG GTGG TCGGGGGGTTGG G GGGG G GGGG GGGGTGTG G G G GTGTG GG G G GGTGG G G G G G G G G GCGGGGGGGG GTG GTG G G G G G G GTG GTGTG GCG G G G GGT CTGGTG GTTGTTGT TTGTGCTG GTGTTG GTTGTGGTGT T T TGTTT T T TG GTGT TGTTGTGTTGTGTGTTG GT T CGGT TTG GTTGTTTTC TTTC G C CTC T A TATAT T TC C CTTTC G A T A C CTC G GTC TT TC ATC G AAT T TATATATATA ATAT T T TAT TGT ACTGTAT T T T TG CGCGAACAAC AAGAGCGGAAACACCAGGAC GCAGAAAACAA G AACCCCCCAAAAGCAAGAAACCAGAAA AATC ACCCA GCAAGACCCTGGTCTGTG C G C C GTG G GTGT T TGT TG C GGTGT CG G CCG C C C G C G GG GC TGTGT T TGTGTGT TC AGTGTG C GGT C CC CGT TG C CGT T TGTTCCTTTGTGTGTGT T T T TGTGT T TGTGT T T TGT T TG GTGT TG GT TTTTCAAG TTT G T A G A GGTGA T A TTG G A AC A GTCTAA GG A C G G G C A G GTCTC G T CTT C AGA C A G C A T G C G T TTGTG GCT G AC C C C CCCACCC GACTCCC G CCC GCCTCTCTCACC C A A C AGT T T GT T T T T T T T T T T T T T T T T T T T TCTCTCTCTCTCTAT TCTGTC C CT T T T T T T T C T T T C C T C T T T T T T T T T T T T C T TTTTTTT980631 1005695019502052165650487756 5 0 0 6 2 5 7 2 7 3 615 11 253010 96793617113561314138777925695255356426467307322 8 7 9 5 432237323715697 4 2727601 4091121314151617181910212223242526 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 41 1 1 1 1 1 1 1 1 1 1 1 1 1 12121212131313131313 3 3 3 3 4 4 4 4 43 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 313131313131313131313

[0098] 4224179498784819881 2 3 6 8 5 9 9 3 2 5 4 3 5 5 7 4 4 7 9 6 6 4 7 31 7 0 1 8 9 6 7 59320373423035593150 3 0 6 3 2 5 2 1 2 2 5 6 5 8 31 1 4 1 5 2 2 9 9 0 4 9 2 3 2 0 1 094953023278602954506832852944338 TTCTT TAT TTTCTTTTT TGTTG TCT T T CT GG GT TT TTTT T TT T T TAT T TCT TTAT TTGT TGTTTTG T T T T TCT T T TTT TG CACGTAC GTTGG GT CTGCCCAC TCCACGT ATAC A CC CCGAGG CGAG C G ACCACTAGG GTT GAC CTTCC A A G A G T C TCA AGTGA G AGTCCCA ACA A ACT ACC A ATCC ACT A A A A A A ACA ACA GCA T A A A A AG GCGC C C T C TTCGTT GTTC CGC C C CGCGCGGC GCGTTC C CGC CG GGGGGGG G TTGGCGGG C G CGGG GGGGGGGGGG G G G G GGGGGG GGGG G G GGGGGG G G G G G G GG GTGTG GTG G G G G GTG GTGTGTGG G G G G G G G G G G GTG G G G G G GTG G G GTGG GTG GGGGGGGGGCG G G G GG GTGT T T TGTGTGG G G GT TGT T TGTGTGTGTGG GTGGT T TGT TT TGT TGTG GT TGT T T T T T TGT TG GT TGT T T T T T T T TGTGT TGTGC A TTC A T C T G C CTC G A G C A CTTCTC T C CT T TG T C C C A GTC G T CATGTGT T T TAT TATG ATGAT T T T T T TGTAT T TAGTATAT T TAT TA TAT TG ATACAAGG G G GG GCACATGCAAA GGCGCA G A GA GGG ACCC A CAC AAC CGTCA CGA A C C ATC A C C C C A A C C C A A CACCC CACAAGTG CTGT TC A C CTGTGT T T CG CTGTGTGTGT CG G CTG GT T TC GTG GTGTTGTC G C C C C G G C C CTGT T TTG GTGTTGTTGTTGT T TTGTG GTTGTGTGTG C C C C C GTGT CTGTGTTGT TTG GT TTGTGG A G C GTGTC GTA G G T CTG A CT TG AAGC C T T AGG T C T G G C A T G C TG GTAGATTACAGTTTGTC TGT GTA T A T C A T T A T G G G ATC A G C TC C C C C C C T C TTCACACTCACCCGCACGCGCACCCA A G TAA T T A TT T T T T T T T T T T TAT TAT T T T T T T T T TCTCTCTCT TCTCTCTC CT T T T T T T C T C T T T T T T T T T T T T T T T T T T C T T TTTTT58 0295215213990534177084612046433462 610 0 3 9 2 907 6 3 5 8 23 496 4 5 8 7 8 0 8 4 7 5 6 9 5 7 03038 76 4957013653103 3 9 4 7 3 31 1 1 4 1 3 6 1 6 3 1 6 2 7 4 1 3 4 3 3 1 3 2 6318673542483015464748494051525354555657585950 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 81 1 1 1 1 1 1 1 1 1 1 1 1 1 16161616161616161616 7 7 7 7 7 7 7 7 73 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 313131313131313131313

[0099] 3123133934784057 464 1 8 4 9 5 2 2 3 9 9 6 7 4 2 8 3 957628530761 31334 27650971104744310 90 7391 18 79783453 4765 0 568 019 2 6 0 573 6 456 7 4 1 7 8 6 6 29677 71 1209 29 91709639 81 TTGTT TTT TT TTCTTT GC TT GT TT G G TTT GTT T T T GTCATGT TCT T TT ATGT TTT TTTG TTTTGT T T TATTT T TCTTT TGGTGG GGCCC TC A AGAG TTCGATTG TTGC AAATGT C AG TG GAATTCAGGCAC ATTA GAGGAT A A C CTTCA A ACACAAAT TCA ATTT A GCATA C G C CCT T ACAC GT A A C T G ATA TCAT G A CATACCC A A A A CAG GGTCGTT C C C CAT G G GCCT CGG G GGG GGGT GCGG GTGTTCTCGGGT C C TGT GGG TTCTGAC GCGGT C C CGTCG GGGC TGG T TTG CTGGG GCGGGGGG G G GGTGTG G G GGGG GTGTGG GGG G G G GGG GGGG G G GG GGTG G GG GGGG G G G GGCGTG GTGG G G G GCTG G G G G GC GGG GC T T T T TG GT T TGT TGCGTGGTGT TGTG GTG GTGT T TGTGGTTATGTGTGTGTG GT T TGTGTGT T T T TGT TGT TTATA T T ATT G A G ATT TTT G A C G C T CTA ATT GTTCTGTGTG GTTCTCTCTTTC GTTTA AT T T T T T TATGT T TAT A TATATGTGT T TA AT ACTGTAT T T TATG GATA ACA A GG GACAAG CC A C A AA GGAA GAAA G TA GTGGAGGAAGA CGC CACGCGC A A ATC ACC C A C A AAC ATC A A C A A CAC C A A ACCTG CGTGTC C C C C G G A C G C CGT TGT T T TGT T TGTGT TGGTCGTG G C G C GGTGT TGCC GGC T TG GCGTG CGT CC C G G GGT TGT T CCGTTGTTGTGCTTTGATG GTTTTTTGGTGCTATCTGGT T T TCC CT TGTG GT T T TGT TGTGTGT TGTGC AGCC G TTCTC GTG C G C GTCC A T C G CCAGTCTAGCGCAA T A G C T CCCCTCTCTCACACAA T GCCCTCGCCGGG T TGACACGA CCT T GGGTA G CGG C A AA G G C GGT A T A TCACTTTTCTCTTTTTTTTTTTTTTTCTTTTTTTCTTTTTTTCCTCTTTTCTCCTCTTCTTTTCCTCTTCTTCTTGTTTTC1056490950021465153131074459105346577 0 4 7 3 7 9 2 9 3 4 553 9 19 6 4 5 3 6 1 5 1 7 8 7 9 1 4 7 4 41587344539592112177 0 453 7 5 73 3 6 6 3 1 1 4 4 3 1 6 2 1 1 7 6 3 2 6 4 3 7 7 6 3 376543363977697081828384858687888980919293 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 21 1 1 1 1 1 1 1 1 1 1 1 1 1919191919191910202020 0 0 0 0 0 0 1 1 13 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 323232323232323232323

[0100] 1218 12 92516 7 47162 4 2 1 3 3 9 4 7 489 4 482 1 4 5 5 9 9 7 5 1 2 87 1 9 732171506191548816637932453841 7 9 9 9 8 1 0 7 8 66 2 256 0 4 9 0 80218 4 8 8 9 3 6 4 5 829 6 47 9340180219737569946252 TCTTGG TTTTG T TTTTG T T TCT G TT CT T TTT T T G T G T GCT TGC CTAC TTCGTGTTCT TCTGCTTC GT CTGAT TCG TTGAGTCTTTGG GTT T T TTTCAGCCGT CCT TCTGGT T T T TTC GAGTCCGAGATT CC TC A A AC A T A C TCCA ACCC A ATT TTATTGTTGACG G T C G A AAT C A CTTA A ACA ACC A ACA C A C AC AA A A GGA A A T A T AATGT CGCGCGG TCGCGCGTTCGC T C TG TT C C CACGC CGTTC TTC TGTGC GGG G G G GGGGGG GGGGG TAG TC GTTG GGGGA GGG CGGAG TCGG GGGGTG G G GG G GTG GTGG G GGGG G G GGGGGGG G GGGG G G GGGG G G GGGGCG G GTG GTGTG GTG G G G GTG G G G GCG G G GCG GCG GGC TTGATGTTG GTTGTGTGTTGTTGTGTTGTGTGTTGTGT TTG GT CTGTGTGC T T TTG GTTG GTGT TGT TTGTGTGTTGTGT TTGTGTTA GTC GTG G TTA C G G C CTT GTC A T T T CTC A G CTT T G A T ATC CAT T TGA GT TGAT T TGT TAAT TGT TAT TATGT T T TATGT T TATAT TAATGGCCGCCCGGAAAAAGAAGAATCAGAA G AGC A AGAGAACCCACACGCGACTG G GCC GCCCGC AAAATGAAAGAACAGAATAACTC C C G G G GGCTGTGT TGT TGCG CGT TG C G GGTGT TGCG G C CGT T T CC CGTGCCGTC C C C GGCGT T T TG A G G G G A CGTGT T T T CGT TGCTGCTGT TGT TGT TGT TG GTGT T T T T TGTGTGT TGTG GTGT TGT TATA C GTT G GTTT G GTT A ATT C C ACT C A C C ATT G A GTT G G G A GTCGCTCAACTTCGACTGCTCAT A A T A GGACGCCCTCCCAC T GCTCACTCAA AAGCCG TGG GATTAATGCACTATATAT TTA ACCA AGTTCTTTTTTTTTTTCTTTTTTTTTTTCTTTTTTTCTTTCCTATTCTTCTTCTTCTTCTTCTTCTTTTCCTTTCCTTTC021813442592091074 2182955679699 046 1790 6 5 0 9 2 0 5 0 9 3 0 2 04 7 8 5 9 4 1 8 7 199 1 9 8 4 7 347 665349745094594893 9 1 1 1 3 73 6 3 4 3 4 4 7 1 2 1 2 7 3 1 6 6 1 6 4 1 4 7 2527187428773663141516171819102122232425262728 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 62 2 2 2 2 2 2 2 2 2 2 2 2 2 22222323232323232323 3 3 4 4 4 4 4 4 43 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 323232323232323232323

[0101] 972157509 296 9 3 9 7 8 5 2 6 2 749 3 9 5 1 8 9 6163798 4 4 7 6 1 61 6 5 23469831568150423540861519676065 9 4 7 8 8 9 7 1 43 2 0 1 9 6 109 7 0 2 9 7 9 3 4 3 178 2 984351772 726975 760510717090 TTTT T TG T G TCT T T G T T GTT T TTT T TTTTG T G G TCT T TCTCC TTTC GACGT TGGT TGAAC AG TATC GCT T TCGT TTGTT GTTCTCAT T T T T T TTTAC T G T G C G C CT T TATCCTTT TGT T TCC GT TT CTCCCAATC CA AG A AAG CAA G G CGGATTAGATTC TGCC A T GGCTA TGACAC TT A C ATT A A A T A A T A A A AGAATAACT A CCT ATT A A AG GCG GG GGGT C TGTAGGTCGGT C C C TGT TCCG GGGCGC TGGGTC C C C C C CTG G G G G G G GTGTCAGTGTT C T C C CGTCGGTTGGGGGG GGG GGGGT TG GG G G G GGGGGGG G G GGGGGGGGGG GGGG G G G G G G G GGGTGTG G GTG G G G G GTG G G G G G GGGGGGGTGCG GCG G G G G GG GTT TG GTGT TTGA AT TGTGTTGTTGT T TTG GTTGTGT TGTTGCTGT T T T T T TTG GTG G G G G GTGTTGTGCTGT T T TTGTGTGTGTTGTT TT TA AT TG A C C C T C T T AGT T T TATATAT T TT G CTT CTCTCTTTTTC C C C C T C C C G CTATAT T TAT T T T T T T TATAT TATAT T T T TCCACAG GGACACTACACGAGATACGAAACTCGGATGAACAG G A A A GCCACACTCA G AGCA ACCA AG CACAG AAGCTACCG ACACTCTACTC G CGTGT TGTC C G G CGC TG C C GGTGC TGGT TGTGTG C CGT T TC C C CCC CCC G GGT T T T T T T TGCG CTG C C C C CGTGT T CGTGT TTTGTGTTTGTATGTGGTCT TGG GT T T TGTGT TGTGTGTG G G GT TGTGTGT T TG GTAACT A A CTT ATT TT T G G G T G A T CTTTCTTTC G CTT G T T A ATC TGT G A TAT A GTC G T A T A T G CAA AGATG GCA T GC CTCCCGC CAC CAC GTCGCCC GACCC GT T G T T T T TGTG GTCG A AT T T T T T T T T T T T T T T T TCTCTCTCTCTCTCTCT TCT T TCTC C CT T T T T C T C T C T T T C T T C T T T T T T T T C T C CTT CTTTTTT06709539 585797667997398177104375 905 9 0 7 5 6 6 4 0 49475 58 0 1 9 597 5 9 4 7 0 3 0 8 4 60895 74 300541555 4 1 2 2 764 209 1 51 3 1 2 6 2 7 2 6 1 1 3 7 2 1 6 3 4 4 1 411149744569776915374849405152535455565758595061 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 02 2 2 2 2 2 2 2 2 2 2 2 2 2626262626262626262727 7 7 7 7 7 7 7 7 83 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 323232323232323232323

[0102] 298827659 6 299 792 1 441 3 4 9 8 2 5 8 2 635 2 3 876 3 9 7 2 8 1 24 4 0 89060479104617321772498396292731 9 0 6 8 0 4 2 5 86 9 7 2 9 6 9 878 022 4 070 7 6 1 2 5 9 6 4 66 632063 19 74911871645816 GTT T G GTG TCTTT T T GT TGTGTTTT TTT G G T G T G GC CGGT TAT TGT T TGT TCT TAT TT TG G AT TCTATGTCTTT T T TCT TGT TA CG A T A TCT AC ACGAGGGA C GG TGATAC T G GT ATAGCG C A CG T AGTG C AC CAT G A T A TTCAGAAG ATAA C G T TAA G C TAGGTC CCTA A TG CC C A C A ACA A ACCC CTT TC ACA G ACA CTT A T ACT CCCATTC CGG GTGG GT CT T T C T CAT GC CTTATTGGTTGGG GC TG G TT CGCGG TAG G GTTGGGGGC GCGGGTTATC TCG TAGTGTT T TATGT TGGGTGGGGGG G G G GGGGGGGGGG G G G GGGG GCGG G GGGT TGCG G G G G G GGC C CGT TGT TG G G G GGT T TGTGTG G GTG G GGT TG G GTGTGTGC TGGTGGGCGG G GGCG GG GGGGGT CGGTG G G GGCGT T TTGTT T TGTGT TGT TGTGT TGTGT T T T TGT TGT T T T TGT T TGTG GTTCATCTC T C C C CTT TTA ATAT T TAT TAT TGATCTTTCTGACCTCATTTGATA GT TC T TGTAT TG AAA TCTT A C C TTAT T TC CATGT T T TCGCCCCCA ACGCCCTACGCCGCTCGG AAATC CTCCC C CCC C C GCAA ACAAGCACCACAGGAGGACC GC G AAACTG CT C A AAC G GC AAC GCAAAAACTACCGAAAACCA ACACCCTC GCC A CCG C C C CGTG GT CGT CGT TGT T T T TGGCGGT TGT CGTGGCGTGTGTGCGT TTGGT T TGGC A GTGT TGT TGT TG G GTGT T T T TGTGTGT T T TGT T T T TG GTTC G TT C AAC A C GTCTC A C G A G GTT A GTC A C G G C GTG C ATT CTGTTCGCACGAACT GGTGCAA G T T C GCCCTCTCACACTT G TCGCGCAGGTT G T A G G GGT C A T G A TT GAA T AA AGC CA AACCCTAGTTTTTTCTACTATTTTTTCTTTTTTTTTTTCTTTTTTTCCTCTTCTTCTTCTTCTTTTACTCTTTTCCTTTCTCTCTC30956987562333 2930619181589983306418 9 5 7 2 7 1 1 174 5 3 1 2 68 5 3 6 7 8 5 347 6 1 1 7 7 4 9 2 81891326454726549773 7 9 8 0 9 16 3 1 6 6 6 6 6 1 4 1 1 3 6 3 1 7 6 1 3 2 6 1 3 76666925676566618283848586878889809192939495 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 42 2 2 2 2 2 2 2 2 2 2 2 2 2929292929203030303030 0 0 0 0 1 1 1 1 13 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 333333333333333333333

[0103] 427183 69 553379585 6 9 5 5 6 6 8 4 7 3 3 1 4 9 9 3 6 1 2 8 4 442 7 47 3 3 2 5 3 38550436006828562697902076 8 6 2 8 7 4 7 9 1 6 3 82 4 7 790 7 0 9 6 5 9 5 0 0 8 0 1 0 3 72818655411089823390052 64 4703 TTT TCT TG G T G T G T T T T TT CG T T T T TCT T T T T T TTTTT TTAACCGT T TCTT T T TTC C T CAA ATCTTACT TACTC C GT T T T T TGCG TGG GTTT T TGG T AAT GCTT TAG AT TGC GTGTTTTTTTT CCACCAGAACCGACCCATCTTAG C A T T A GT AA TAC ACGT CAT AAGACGG GCTA CC GGC C CA ACACA AC A CT A A A A AACA A A A A A ACACAA ACGG GTGG GTT C TCTCG TCGGTGTCGCGGGGGGCGGGG TGTTTTCCGC C C C T CGGGG G GGT GC C C C CGGGG GGG GGGC C CGGGG G GGGG G G GGGG G G G G G G G GTGG G GGGGGGGGG GGGGGGG G GG GGGTG G GGT T CG G G G G GTG GTGTG GTG G G G G G G G GTG G G G G GGTG G G GTTGGTGTGTTGT CTGTGTTGTTGTGTTGTGTGTTGTGT T TTG GTGTTGT T T CTGTGTGTG GT T T T TTGTG GTG GTGTTGT TTG G GTTCGTATCTC T TATCG G AT TC A G C G TATAT A T T TTATGTA C T C T A CTT C TTT CTC T C TTCTT GGTGT T TATAT T T T TATAT T T TATGTAT T TCGCCTAAAAGGGAGGAACGACAACCTGCACGGCACAAAAGAGA AGATCACCGCACAGACG AAATCTACCCCCGAGA AGATCAACATACAGAACG A GAT TGC AAATCTGCGTGTGTGTC G G ATG C A GGT TGGTGTGT CGTGGTGTGT C CGTGGT TGGT TGT T T TGT TGT T TTGGTTTT T TGTGT T T TGT T TG GT T TGT TGT TGTGTG GTGT TG GTGTATT G TTC CGGCGTGCTTGC C C G C G CTCTT TGATCTG G A G C T TATC CTC C G T G T CTCTT C T GTT G TAG G A A A TTC T A A C G T T T T GC C C G T C T C GCCTCTCTCACAC GTCACTCCCGC GT G C T A G G A T C TT T T T T T T T T T T T T T TAT T T T T T T TCTCTCTCTCTCTCTCTC C CT T T T C T C T C T T T T T T T C T T T T T C T T T T T T T TTTTTTT62270674066657997525119344615801301 3 131 5 1 3 4 0 7 7 5 6 206204139787015634761334441473716166 163 84333646 119 553641392 9 2 3 5 1 8 9436134733193421122 351617181910212223242526272829 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 83 3 3 3 3 3 3 3 3 3 3 3 3 3233333333333333333333 4 4 4 4 4 4 4 4 43 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 333333333333333333333

[0104] 53 880125329950 3 3 598 9 6 4 4 3 8 5 5 4 258 7 4 1 1 1 6 2 5 4 725 13 279866342170 08 326028587 44 264858031796800013238514597516 15 56 8 0 1 6 0 1 7 4 29286296943629878433 27 97 CCT T T TC CGTTTG T T T TTT T TTT T G T T T G G T T T T T T TGTGTTTCTTTATT TATGA GATTTGGTCCTCTAGTTTTTTT T T T T T T TGCTT GTC C GTG TT TTC GT T T T T T T T TAT CAG C TTATT GTGTTCC ATTC A AGACAAATA T ATAT ACACA ACGTCTGATATAATATAAGATCATAATAG GCT AAAGTAG TA AC CC G TTAC CT CAA A A A A ATTTATC CGCG GC CGG GG GT TGGG GT T G G GTGGGGC G G GTC C CGG G GGGGGGGGGCGGGC C C C CGGG GGGGGG G GT CGG G GTAGC C TGG G TC C C C C CGG G GGGGTGC GG G GG GG GGGGGGG GCGG GGG GG GGCG G GTG GGC TG G GTGTGTG G G G G G GGGG G G GTG G G GC GGG G G G G GTTGTCTGTGTTG GT CTG GTGTGTGCTGTTGT TTGTGTTGT T T T TTGTGTG G GCTGTGT T TTG GTGTGT T T TGGTGTTGT TTGTGTGTTTATC CTA TTC C GTAT TAT TGT T TG GGACTC T C G C C GTTTC G C CTT T T CGT T TT C C T T C CAT T T T T T T T T T TAT T TA AT T T TAT TGTACAACCGCGAAACCA ACACACAAACAGAGCCACCG GCACGA G A A G ACACACTCTCCCTCAAACGCAAACGC ATAGGCCGGATCTCAATC C G C CGCTGT T T TC C G CGC TGTGTGGTC C C C C C C C C C CGT TGTGT T T T T T T TG C G CGTGTGT CCC AGCC G C G C CGT T TGT T TGGTGCTG GTGTGT T T TGT T TGTGTGTG GTGTGT T T TGT TG GTG GT T TTCTTC CTT GTT A G A G T G G C G CTT C C C G A GTT G GTCTT GTT G A GG AATGTATAGATTGT G T ATA T T C C A A A C TAC T A CAACT T G G T G GC G C C C C T TACGCGC GCCGCGCTCACTCCCCCA A A TC GC T T T A G TT T T T T T T T T T T T T T T T T T T TCTGTCTCTCT T TCTCTCTCTC C CC T T T T T C C T T T T T T T T T T T T T T T T T C C T T T TTTTTTT485160 150 31309614015324012167848051 5 0 7 7 6 3 7 9 3 6 797 9 97 6 5 135 598 7 5 4 9 8 1 0 0 5 7 5263638767695247 1 5 2 103 2 2 46 6 4 4 6 6 2 1 3 6 3 4 4 3 3 4 1 1 3 6 3 2 4767632013462411494051525354555657585950616263 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 23 3 3 3 3 3 3 3 3 3 3 3 3 3636363636363637373737 7 7 7 7 7 7 8 8 83 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 333333333333333333333

[0105] 127046 32 83652 1 8 1 8 2 315 2 2 5 474 9 7 3 5 9 9 2 7 626 4 8 6 8 73 9 2 667174470403507230235563199587 0 3 0 4 7 0 5 5 2 82 4 4 915 7 323 2 4 9 8 6 348 7 8 1 772 9 7983828896373 78 0425254921 TTG TTTTGTTTT TT TG G T T T G T T G T G G TTT T TT TT TCTGG GT TTGT GAGCGTAA TC TAT TGTGT T TCT TCG G GCT AACTGT T T T TCG TTA GACT T TAG GTC CT T TG AC C GT TGGTCC A AACACAGTCCA C ACA AGTGT CAA GCAATCATTAATGAAAC AC CCGTGT AG GTA ACT G AAC A G ACA A T A A C A T C A AC TAGATAAAC C CCACA ACGTT CGGTTGGGC TGG GC C C TGTGTGGG G G TGTTATTGC CGG GT CGTCGC TGG TCGGTGTTGTCGG GC C CGGGGGGGGGGGCGG GGGG G G G G G GGGGTGGGGAGGGTGCG GTG G GTG G G G GG G GGGG G GGGG G G G G GTG G GTG G G G G G G G GCG GT GGGGGGGGGGGGTGTG GTTGCTGTTGTGT TTGTGTGTTGT T CGCTA TTG G GTGCTGTGT TTGTGTTGTTGT CTG GTTGCTGTGTTG GT T TT TGTGTGTGTGTTGTGTATAATG G C C G TTTTTTC CAA TGT T TGT T T T TC C G C C C CTT T G C C A GATAT T T TATAT T TAT T TAT TA T G A G C TGT TAA TGA T TAACGCACCGCGACAAATCAAACA A AGATCCCAC AAAAAGCTACTCGCAGCAGAA CG AC CACTCGAAACAGAACCCAG AC ACGATAGATCGCCTGCC C G CGT TGT TG A C C C GGTGT T T C TG C C C C CGC TGTGTGTGTG C CGT T CC C G C GGT CGT T TC ACC CGT TGT TG G GGT T TGCTGGTGGT TGCT TGTGTGTGTGT TGGT TTTAT T TG GAT T TGGTTTGCTGT TGGT TGT TG GAT T TGTC C A T T C C T G G C TGACTAG A TAC G G T T A TTCGA T T ACT A ACA TC C C C T T G GGTAT A T G A G T T AC G G CGCTC GACTCTCACTTGC G AGCGCGC GA CGGGG G A A T G A C CT T T T T T T T T T T T T T T T T T TCTCT TCT TGTCTCTCTCTCTC C C CT T T T T T C T T T T C T C C T T T C T T C T C T T T T T TTTTTTTTT1658703963387600 6 90705 06806 273020 7 5 313 0 511 7 5 1 3 2 22 7 7 8 4 3 6 7 73248 5 876 4 490 017877607 17 9 5 238 0 9 3 3 7 7 51 6 6 1 1 4 6 3 1 6 7 6 4 4 6 1 1 6767704914354417112923848586878889809192939495969798 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 63 3 3 3 3 3 3 3 3 3 3 3 3 3 39393040404040404040 0 0 1 1 1 1 1 1 13 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 343434343434343434343

[0106] 1345 42 649958984 34960 9 5 6 9 2 8 7 9 8 1 8 8 1 4 8 5 4 4 3 9 4 3 99 9 7 5 4 36570262646650685272045168 3 9 8 8 9 9 5 0 9 9 2 87 5 737 6 0 8 8 5 54807 4 0 7 2 6 4 3 2 770083457442873484187735902 TTT T TTT T GTTTT T T T T T T TT T TT T TTT T T T TTT TTTGT TTTGTCACTAT GCTATCTCG GTG TC GTACT T T T TAGAG G G CTACTC GGCG TT GTCCTTTT CT TA GGTTT TGGTGTGTACACTCAAAACATAA CCACA GT C GACGA CTAC G G T CCA ACCCTA C TAA AGAGTCT C G A G A A C T G CCACA A A A ACA A AC TT ACA A A A A A A A A A ACAGCGGGGGGGGG TGT CTG T GCG A GG GGGCGGC C CGG GCGG GGGCGG GTGT GC C C CA GGGGGGGGCGGC C C CGGGGGGGGCGGGGCGGGGGTGGGG GCTGTGG G GTG G GGGTGT G G G GGGGGGGGG GGGG G G G G G G G G G G G G G GTG G G G G GTGTG GTG GTG G G GTG G G G GTG GTGGTTGCTGTGTGT TTGTGTGTGTGTGTGT T TG GTGTTTGT T T TGTG GT TGTGTGT TTGTGTTGTGTTGT T TTGTGTGTGTTGTGTTGTTAATCTG GCG ATGTC TGT T TCTA CG A GT TC A ATCTT G GTC CATATAT T T TGA T TT CATATGGAGTCTCTG T C T G T G CGT T T TAT TAT TACCCCTAGAGAAACTAAAAAA A CATA AACGAA A GC GTAAGG ACAAAGC AGC GTC ATG G C G GATC A A A ACCCC C CTC A A ATC C C AAA A C C A C A AGTGGT TGC T CGG GTC GGT TG A G C C CGTGTGT T T TC C GGT TG GGTGT TC C C G G A C CGT T TGT T TGTGTA CGT TA GGTGTT T TGTGT T TGT T T TG GTGT T TGT TGT TGTGT TGTGT T TGT T TGCAC ATCTG A T ATG C G T G C TTA GTCCAGT C GGTAACTTTAAGGG G T A C CGCATACATAA C A C G T G TCTA A TGT ATTGT CGGAT AGTTAC C C C C C C C C C C C CTCTCTCACTCACAC GCCTCGCA C T A A T A G A CT T T T T T T T T T T T T T T T T T T T T T T TCTCTCTCTCTCTCTCTCTCT T T T T C T C T T T T T T T T T T T T C T T T T T T T T T T T TTT7372931925545547712836973323250162 1175 1 6 1 5 6 5 0 5 0 0 390 36 8 3 7 5 5 4 6 3 7 4 6 5 3 5 5 8 44891869925708545702 9 7 519 6 11 3 1 1 1 6 2 7 1 3 2 3 2 4 3 4 3 1 3 7 2 4 4 2 1 15273248152517181910212223242526272829203132 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 04 4 4 4 4 4 4 4 4 4 4 4 4 4 43434343434343434444 4 4 4 4 4 4 4 4 53 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 343434343434343434343

[0107] dareiteroCddetoarCFgscgnol_oennotneif30oneeB6653267 3 6 1 3 711 4 1 7 1 7 7 418 3 227 5 4 9 6e439 50354753238863 86335701445742061319562545v365335077623226322 508642849569 0 406 0 225 5 5 091345533898.90 6 1 8 301 7 0 3 89237 19 4385 93 93048105291814010 98 67467565451554 38 53028 7 9 4 6ag1 0 9 3 9 9 9 9 9.8 8 8. 3 . 1 0 0 9e.4.4.3.3.3.3.3.3 3.8 8 8 83.3.3.3.3.3.3 3 8.83.3 3 8.8 8 73.3.3.3 ffe 1Fhtmul GCA CTC G G T CTA A CC TACAC AACTAT G CGA C TCC CGTTT GG it gc ACAACACCACAACACAC GGA AGA A AAAAC TAAGGGC CCTCACACAC CT A A A ACACA A ATCA A A A ACAACA ACiFfis ni niCGCGCGC CGG G GT CGCGCG GC CGGC C CGCG GC CGodr tu G G GGGG G GGGTC G GGGG GGGG GGGGGGGGG GGg ed p o G GoLsagc onc tG G G G G GeGTGTGTG GTGTGGTGG GTGCGG G GTGTGTGGTGG GTGTGGTGG G G G GTGTG GTGTGGTGG GTG GTniadods G G GTGG GeecTTTTCTTCT TTCTTTGTGTGTGTG G G G GTCTTTTTATTTGGTG G GTTT TTTG G G G GGTCT TTT TGTTTT GTGTCuG A AAG AAG GTGGT T T T T TCT T T TCT TCT T TTT TGAAGCG G GAGGG GCG A A AAATGGAGA Gmietde dqGst cnsAGA AAC AAC A A A AGAAA A ACC AGAGAAA A A A AAAGAnesG G G C GTCTGTGTG GTG G GTGTCTGTG G G G G G G G GE na eu oit di TcGTGTGTGGTGTGTGTTG GT TTG G GTGTGTGT T T TTG G G GTTGTGTGTGTG; tq u a T T TCT TTT T T T T T T T T Ty ueistioCACA GCTGGGGGGGGAGGTACAGGG G G C C T G G G G T Ctlmts na lA iT T C A T T T T T T T T TGTGTGTATATTTGTGTGTGTTTATnaNbouDusmCaTCTTCTTCTTCTTCTTCTTCTTGTTCCTC C C C C C C C C C C C C C CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTg doivhi D 6tdI- 36492392113953116380 4 1 1 5 8 1 1 3 1 8 1 0 4 4 5 6 418179313434819113312483204190915 3 3rnin4 4 3 1 4 4 4 4 7 4 4 4 4 4 4 4 4 4 1 4 4 4140144o3h or0cgBaeeD.r5of 152453454455456457458 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5454546464646464646464646474747474747el stDI 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 343bnau QoE OTS N

[0108] 13776995 63 4 8 1 2 6 3 5 336 5 8 8 5 2 755 1 8 895 3 1 816 1 2 6 5 40 3 2 542438140801398497414694833847 6 5 0 0 3 7 7 6 1 43 5 1 5 724 0 5 5 4 4 4 5 607 4 0 3 0 3 34 237476 35 427065 48 5221249134 GTTCTCTGGTTCT TTGTCTTTTT TCT T TT T TGT TT G G G T T G T T G T T T TTT T TCAGTACGCAT A A GA AT TCGT A CA ACGT T T T TCCGC T G GTGCT TAG TT T T T TCTCC GATATTGG AT T TA CT TAGACTATCAA C G C ACCTA ACACAT C G A ACC A A AGCACA A ACACA AACAAC A AGC G TGA A A A C GCC A CCACA C C T A A C A A T A A A A ACA A AAGGGGGTCCGGGGGGGGGC CGG G GCGGGG GG GGGC T TGG TGTTCTC CAGGGT CGTCGC TGGGTC C CGGGG GCGGGGC C CGG GGGGGGGGGGGG G G GGG G G G GGGG GGGG G G G G G G G G GGGG G GGGG GC T T CG GTGT TGTG G GTGTG GTGTG G GCGTG G G G G G G G G G GTG G GGTGTTGTGTTGTGTGTGTGT TTGTGTGTGTTGTGTGT TTGTGTGTGTTGTTGTTGTTGTTGCTGT T TTGTGTGTTGTGT T TTGTGTGTTCTGTCTC G CTATCTC C CTTTT G C C A C C A T A C C T T C C T G C T CAAA G AT TGA A GT TA GT T TAT T TATAT TATAT T TATAT TAT T T T TAAG G GGAG G G AACAA AAAGAA AT C GGC AGAAG TGTAAGAATAACGA A AGC A A A A CGAA A AGA AGAC CGCA A A C AGA A AAC A C C C A ATGTGT CCTG GTGTGTC G GTGTG G GTG CTG G G C G G G G C G C C C G GGTG G G GTG G GTGTG GT TGT CGGC T TGCGT T C TGT TGTGTGTGT TGGT T T TGT T T T TGT TGTGT TGT TGTGT TGTGTGT TGT T T T TGT TGG G GGG C G G G CTGT G G T C GTT CAGGTTAT G G C T C G C G G G GTC GTGTGT TGTATGTGTGT CTTGTG A T G TT T TT G G A A ATG A G G G A GC C C G C C C C C C C CTCTCTCTCTC G G CTCTCTTTCTC CT T T T T G T TT TTTTTCTTTTTTTTTT T T T T T T T T TTCTC T TTC T TTC C C C C C C CCT T T T T T T T T T T T TCTTTTTTTTTTTTTTTT65143955607364151821738469296765535361374 1 4 0 5 5 8 1 5 3 0 2 1 39 1 1 9 3 4 1 1 1 3 0 1 1 3 0 1 0 8 8 9709018249379805590720 3 9 97 4 4 7 4 4 4 4 4 3 1 4 4 4 1 4 1 6 6 7 1 4 6 4 4 7 4 4 4 4340434046777879708182838485868788898091 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 94 4 4 4 4 4 4 4 4 4 4 4 4 4 49494949494949494940 0 0 0 0 0 0 0 0 03 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 353535353535353535353

[0109] 95852473407 8 1 8 97095 4 9 6 4 4 3 3 9 2 6 288 493 2 3 5 4 8 5 6 69 7 2 8 830866625623942132935096187335 5 9 2 2 0 0 0 7 0 22 9 4 3 6 5 2 0 6 8 61612 0 1 8 2 0 4 5 46333 39 86 40 3605512394361630 GT TTT T T TTT T TTT T T T G TTTCTTG T T T TTT T T T T T TTT TGCGAACCC T T T TGG A G CT TA GCGAGT GTTAA AAT TTCT T T T TAAACCGATATCCCGAG TTGTAG GCTAGT T GT T TC AT TT TAAC ACT CACTACA TTCC CAT T T T T TCCCG TTCGA GAATACCA TCC C GCTA ACAA A AAAA A A A A A AACATAAA ACC ACA ACACAC AAA A A A ATC C CCGGGGC C C C C CGG G G GGG GC C CGG G GCGGC C T CGGGGGTTGCCT CGG T G GTG GTCGCGGGGCGG G GC C CG G GG GGGC CGG GGGGGG GG GGGGGG GGG GGGG G G G G GGGGGG G G G G G G GTG GGT T GGGGG G G G G GG G GGGG GTG G G G G G G G G G G GTGCGTG GTGTGTG G G G G GTTGTTGT T T T TGGTTGTGTG GT T TTGTG GTTGTTGTTGC TTGTGT T TTG G G G GTTC CT TGT T T TGTG...

Claims

CLAIMS 1. A system, comprising: i) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises a modification at the position corresponding to Q147 of SEQ ID NO: 2; and ii) a compound of Formula (A)[Formula A] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - X3is CHRDor C=O; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O- C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen;- RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl.

2. A system according to claim 1, wherein the variant comprises a modification at one or more of the positions corresponding to N149, Q150 and S154 of SEQ ID NO:

2.

3. A system according to claim 1, wherein the variant comprises a modification at the positions corresponding to Q147, N149 and Q150 of SEQ ID NO:

2.

4. A system according to any one of claims 1 to 3, wherein the variant comprises one or more of the modifications: i) Q147A / C / F / G / H / N / S / W / Y relative to SEQ ID NO: 2, preferably Q147A / F / H / W; and / or ii) N149D / E / N / P relative to SEQ ID NO: 2; preferably N149D / E; and / or iii) Q150I / Q / V relative to SEQ ID NO: 2; preferably Q150I / V; and / or iv) S154A / C / E / F / G / H / I / K / L / M / N / P / Q / R / S / T / V / Y relative to SEQ ID NO: 2; preferably S154K / P / Q / A; and / or v) A153F / H / R relative to SEQ ID NO: 2; preferably A153F; and / or vi) F146L relative to SEQ ID NO: 2; and / or vii) F155C relative to SEQ ID NO:

2.

5. A system according to any one of claims 1 to 3, wherein the variant comprises: - Q147H / N149E / Q150I / S154P relative to SEQ ID NO: 2; or - Q147F / N149E / Q150V / S154P; or - Q147W / N149E / Q150I / S154K; or - Q147F / N149D / Q150I / S154P; or - Q147A / N149E / Q150V / S154K; or - Q147W / N149E / Q150I; or - Q147W / Q150I / S154Q; or - Q147W / N149D / Q150I / S154A.

6. A system according to any one of claims 1 to 5, wherein the polypeptide is attached to a target protein.

7. A system according to any one of claims 1 to 6, wherein the polypeptide is attached to the target protein by genetic fusion and / or via a linker.

8. A system according to any one of claims 1 to 7, wherein the compound of Formula (A) is a compound of Formula (I):[Formula I] wherein - X1is C-R and X2is C-R or N; or X1is C-R or N and X2is C-R; - each R, which may be the same or different, is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O- C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - n is an integer from 0 to 2; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen;- RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl.

9. A system according to claim 8, wherein in formula (I): - n is 0; and / or - RAis H or methyl, preferably H; and / or - RBis H or methyl, preferably H; and / or - RCis H or methyl, preferably H; and / or - X1is C-R and X2is C-R.

10. A system according to claim 8 or claim 9, wherein the compound of formula (I) is a compound of formula (Ia):[Formula Ia] wherein - R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or methyl; and - each R20, which may be the same or different, is independently H or C1-6 alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl.

11. A system according to any one of claims 1 to 9, wherein R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-4alkyl, C2-4alkynyl, O-C1-4alkyl, O-C2-4alkynyl, NR10-C1-4alkyl, NR10-C2-4alkynyl, C6aryl, and 5- to 6- membered heterocyclyl, and 5- to 6- membered heteroaryl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6aryl, 5- to 6- membered heteroaryl, and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2, or 3 R20groups, preferably one R20group.

12. A system according to any one of claims 1 to 9, wherein R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-4alkyl, C2-4alkynyl, O-C1-4alkyl, O-C2-4alkynyl, NR10-C1-4alkyl, NR10-C2-4alkynyl, C6aryl, and 5- to 6- membered heterocyclyl, and 5- to 6- membered heteroaryl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6aryl, 5- to 6- membered heteroaryl, and halogen; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2, or 3 R20groups, preferably one R20group.

13. A system according to any one of claims 1 to 9, wherein: i) R1is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; ii) R2is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered heteroaryl or with 1-3 halogen substituents; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2, or 3 R20groups, preferably one R20group.

14. A system according to any one of claims 1 to 9, wherein: i) R1is selected from H, NH2, OH, OMe, halogen, methyl, NH-C1-3alkyl, and unsubstituted NH-C3alkynyl; wherein each C1-3alkyl group is independently unsubstituted or is substituted with 1 or 2 phenyl or pyridinyl groups; wherein said phenyl or pyridinyl groups are each independently unsubstituted or substituted by methyl; and ii) R2is selected from H, N(R10)2, OH, OMe, halogen, unsubstituted C1-4alkyl, CF3, phenyl, piperazinyl, and morpholinyl; wherein said phenyl, piperazinyl, and morpholinyl groups are independently unsubstituted or substituted by C1-6alkyl, preferably C1-4alkyl, more preferably methyl.

15. A system according to claim 10, wherein R1and R2are defined as any one of the combinations:

16. A system according to any one of claims 1 to 7, wherein the wherein the compound of Formula (A) is a compound of Formula (Id):[Formula Id] and wherein R1and R2are defined as in any one of claims 10 to 15.

17. A polypeptide comprising a variant of the amino acid sequence of SEQ ID NO: 1, wherein the variant comprises (i) a modification at the position corresponding to Q147 of SEQ ID NO: 2; and (ii) a modification at one or more of the positions corresponding to N149, Q150 and S154 of SEQ ID NO:

2.

18. A polypeptide according to claim 17, wherein the variant is as defined according to any one of claims 4 to 7.

19. A system according to any one of claims 1 to 16, or a polypeptide according to claim 17 or claim 18, wherein said polypeptide has at least 70% identity to SEQ ID NO:

2.

20. A system according to any one of claims 1 to 16 or 19, or a polypeptide according to claim 17 or claim 18, wherein said polypeptide is capable of binding a compound of Formula 21. A system according to any one of claims 1 to 16, 19 or 20, or a polypeptide according to claim 17 or claim 18, wherein the binding of said polypeptide to a compound of Formula (A) is stronger than the binding of SEQ ID NO: 2 to said compound of Formula (A).

22. A polynucleotide encoding the polypeptide according to any one of claims 17 to 18.

23. A polynucleotide according to claim 22, wherein the polynucleotide further encodes a protein of interest in-frame relative to the encoded polypeptide.

24. A vector comprising the polynucleotide according to claim 22 or claim 23.

25. A cell expressing the polypeptide according to any one of claims 17 to 18, or comprising the polynucleotide according to claim 22 or 23, or comprising the vector according to claim 24.

26. A compound of Formula (B),[Formula B] wherein - X1is C-R1and X2is C-R2or N; or X1is C-R1or N and X2is C-R2; - X3is CHRDor C=O; - A: R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; or B: R1is selected from OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O- C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen;and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from R20, OR20, N(R20)2and halogen; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RDis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2 and halogen; and - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl.

27. The compound according to claim 26, wherein the compound of Formula (B) is a compound of Formula (Ib):[Formula Ib] wherein - X1is C-R1and X2is C-R2or N; or X1is C-R1or N and X2is C-R2; - A: R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl;or B: R1is selected from OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O- C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, O-C1-6 alkyl, O-C2-6 alkenyl, O-C2-6 alkynyl, NR10-C1-6 alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferalby 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - RAis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RBis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - RCis H or C1-4alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; and - each R10, which may be the same or different, is independently H or C1-4alkyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from OR20, N(R20)2and halogen; - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl.

28. A compound according to claim 26 or claim 27, wherein said compound is a compound of formula (Ia),[Formula Ia] wherein - A: R1is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; or B: R1is selected from OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O- C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; and R2is selected from hydrogen, N(R10)2, OR10, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, O-C1-6alkyl, O-C2-6alkenyl, O-C2-6alkynyl, NR10-C1-6alkyl, NR10-C2-6alkenyl, NR10-C2-6alkynyl, C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, and C5-10carbocyclyl; wherein each alkyl, alkenyl and alkynyl group is independently unsubstituted or is substituted with 1, 2 or 3 substituents independently selected from C6-10aryl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl, C5-10carbocyclyl, OR20, N(R20)2and halogen; and wherein each aryl, heteroaryl, heterocyclyl and carbocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3, preferably 1 or 2 substituents independently selected from R20, OR20, N(R20)2and halogen; - each R10, which may be the same or different, is independently H or methyl; and - each R20, which may be the same or different, is independently H or C1-6alkyl which is independently unsubstituted or is substituted with 1, 2 or 3 substituentsindependently selected from OR30, N(R30)2and halogen, wherein R30is H or methyl; preferably each R20is independently H or methyl.

29. A compound according to claim 26 or claim 27, wherein: i) R1is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; ii) R2is selected from N(R10)2, OR10, halogen, C1-4 alkyl, NR10-C1-3 alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered heteroaryl or with 1-3 halogen substituents; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group.

30. A compound according to claim 26 or claim 27, wherein: i) R1is selected from OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; ii) R2is selected from H, N(R10)2, OR10, halogen, C1-4alkyl, NR10-C1-3alkyl, and NR10-C2-3alkynyl, O-C1-3alkyl, and O-C2-3alkynyl; phenyl, and 5- to 6- membered heterocyclyl; wherein each alkyl and alkynyl group is independently unsubstituted or is substituted with 1 or 2 substituents independently selected from C6aryl, 5- to 6- membered heteroaryl or with 1-3 halogen substituents; and wherein each aryl, heteroaryl, and heterocyclyl group is independently unsubstituted or is substituted with 1, 2 or 3 R20groups, preferably one R20group.

31. A compound according to claim 26 or claim 27, wherein: i) R1is selected from H, NH2, OH, OMe, halogen, methyl, NH-C1-3alkyl, and unsubstituted NH-C3alkynyl; wherein each C1-3alkyl group is independently unsubstituted or is substituted with 1 or 2 phenyl or pyridinyl groups; wherein said phenyl or pyridinyl groups are each independently unsubstituted or substituted by methyl; andii) R2is selected from N(R10)2, OH, OMe, halogen, unsubstituted C1-4alkyl, CF3, phenyl, piperazinyl, and morpholinyl; wherein said phenyl, piperazinyl, and morpholinyl groups are independently unsubstituted or substituted by C1-6alkyl, preferably C1-4alkyl, more preferably methyl.

32. A compound according to claim 26 or claim 27, wherein: i) R1is selected from OH, OMe, halogen, methyl, NH-C1-3alkyl, and unsubstituted NH-C3alkynyl; wherein each C1-3alkyl group is independently unsubstituted or is substituted with 1 or 2 phenyl or pyridinyl groups; wherein said phenyl or pyridinyl groups are each independently unsubstituted or substituted by methyl; and ii) R2is selected from H, N(R10)2, OH, OMe, halogen, unsubstituted C1-4alkyl, CF3, phenyl, piperazinyl, and morpholinyl; wherein said phenyl, piperazinyl, and morpholinyl groups are independently unsubstituted or substituted by C1-6alkyl, preferably C1-4alkyl, more preferably methyl.

33. A compound according to claim 28, wherein R1and R2are defined as any one of the combinations:

34. A compound according to claim 26, wherein the compound is a compound of Formula (Id):[Formula Id] and wherein R1and R2are defined as in any one of claims 28 to 33.

35. A pharmaceutical composition comprising a compound according to any one of claims 26 to 34 and a pharmaceutically acceptable excipient or diluent.

36. A kit comprising:a) a polynucleotide according to claim 22 or claim 23, a vector according to claim 24, or a cell according to claim 25; and b) a compound according to any one of claims 26 to 34 or as defined in any one of claims 1 to 16.

37. A method for degrading a target protein of interest in a cell, the method comprising: a) introducing a polynucleotide according to claim 22 or claim 23, or a vector according to claim 24 into the cell such that the cell expresses the polypeptide attached to the target protein of interest; b) contacting the cell with a compound according to any one of claims 26 to 34 or as defined in any one of claims 1 to 16; thereby inducing the degradation of the target protein of interest.

38. A method according to claim 37, wherein the polypeptide expressed by the cell is attached to the protein of interest by genetic fusion and / or wherein the polypeptide is attached to the protein of interest by a linker.

39. A compound according to any one of claims 26 to 34, or a pharmaceutical composition according to claim 35, for use in medicine.

40. A compound according to any one of claims 26 to 34, or a pharmaceutical composition according to claim 35, for use in degrading a therapeutic target protein or a cell comprising a therapeutic target protein in a subject; preferably wherein said target protein is attached to a polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16.

41. A compound according to any one of claims 26 to 34, or a pharmaceutical composition according to claim 35, for use in the treatment or prevention of cancer in a subject in need thereof.

42. The compound or pharmaceutical composition for use according to any one of claims 39 to 41, wherein the subject has been subject to CAR T-cell therapy, wherein the CAR T-cell therapy comprises: a) isolation of T-cells from the subject;b) genetically modifying the isolated T-cells such that isolated T-cells express a chimeric antigen receptor and a polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16; c) infusion of the genetically modified T-cells into the subject.

43. The compound or pharmaceutical composition for use according to claim 42, wherein the chimeric antigen receptor and the polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16 are attached by genetic fusion and / or wherein the polypeptide is attached to the chimeric antigen receptor by a linker.

44. A method comprising genetically modifying T-cells isolated from a subject such that the isolated T-cells express a chimeric antigen receptor and a polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16.

45. The method according to claim 44, the method further comprising: a) isolation of the T-cells from the subject; and / or b) infusion of the genetically modified T-cells into the subject.

46. A polypeptide according to according to claim 17 or 18, or defined in any one of claims 1 to 16, or a polynucleotide according to claim 22 or claim 23, or a vector according to claim 24, for use in medicine.

47. A polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16, or a polynucleotide according to claim 22 or claim 23, or a vector according to claim 24, for use in the treatment or prevention of cancer in a subject in need thereof.

48. A polypeptide according to claim 17 or 18, or defined in any one of claims 1 to 16, or a polynucleotide according to claim 22 or claim 23, or a vector according to claim 24, for use in a method of CAR T-cell therapy in a subject in need thereof.

49. A method for identifying an orthogonal IMiD compound and polypeptide degron combination, the method comprising screening for increased binding affinity of one or more compounds according to any one of claims 26 to 34 or as defined in any one of claims 1 to 16 against a polypeptide variant of SEQ ID NO: 2 or SEQ ID NO: 3 relative to a polypeptidesequence consisting of or comprising the polypeptide sequence of SEQ ID NO: 2 or SEQ ID NO: 3, thereby identifying an orthogonal IMiD compound and polypeptide degron combination.

50. The method according to claim 49, wherein the polypeptide variant is as defined in claim 17 or 18 or defined in any one of claims 1 to 16, and / or wherein the compound is as defined in any one of claims 26 to 34 or as defined in any one of claims 1 to 16.

51. Use of a compound as defined according to any one of claims 26 to 34, or as defined in any one of claims 1 to 16, in selectively degrading a target protein of interest in a composition comprising the target protein of interest and a polypeptide of SEQ ID NO: 2 and / or 3.

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