COSMETIC COMPOSITIONS CONTAINING HIGH QUANTITIES OF HYDROXYPROPYL TETRAHYDROPYRANTRIOL

Abstract

COSMETIC COMPOSITIONS CONTAINING HIGH AMOUNTS OF HYDROXYPROPYL TETRAHYDROPYRANTRIOL This disclosure relates to stable cosmetic compositions containing high amounts of hydroxypropyl tetrahydropyrantriol, and optionally containing 4-tert-cyclohexanol. The cosmetic compositions further include water, a plurality of emulsifiers, fatty alcohols, additional fatty compounds, and thickening polymers. Processes for stabilizing cosmetic compositions containing high amounts of hydroxypropyl tetrahydropyrantriol, and optionally 4-tert-cyclohexanol, and processes for treating the skin with the cosmetic compositions are also described. Figure for abstract: none.

Description

Title of the invention: COSMETIC COMPOSITIONS COMPRISING HIGH AMOUNTS OF HYDROXYPROPYL TETRAHYDROPYRANTRIOL SCOPE OF DISCLOSURE

[0001] The present disclosure relates to stable cosmetic compositions that include high amounts of hydroxypropyl tetrahydropyrantriol; and to methods of stabilizing the cosmetic composition containing high amounts of hydroxypropyl tetrahydropyrantriol. The present disclosure also describes methods of treating the skin with the cosmetic compositions. SUMMARY

[0002] In one aspect, the present disclosure is directed to, among other things, cosmetic compositions including a surprisingly high amount of hydroxypropyl tetrahydropyrantriol. In various embodiments, the compositions further include surprisingly high amounts of 4-tert-cyclohexanol. However, the inclusion of 4-tert-cyclohexanol is not required and in some embodiments it is not included in the cosmetic compositions. These active ingredients provide a myriad of cosmetic benefits to the skin but have historically been very difficult to incorporate into stable cosmetic compositions, particularly in high amounts. The inventors of the present disclosure have developed, among other things, surprisingly stable compositions that include high amounts of hydroxypropyl tetrahydropyrantriol, and optionally high amounts of 4-tert-cyclohexanol.Due to the high amounts of these ingredients, the cosmetic compositions provide exceptional cosmetic properties to the skin. Due to the high amounts of hydroxypropyl tetrahydropyrantriol, the cosmetic compositions reduce the appearance of fine lines and wrinkles, enhance hyaluronic acid production via stimulation of glycosaminoglycan (GAG) synthesis, thereby softening the stratum corneum to relieve cumulative stress on the epidermis and dermis, etc. Due to the high amounts of 4-tert-butylcyclohexanol, the cosmetic compositions reduce skin irritation, soothe the skin, and / or reduce or alleviate stinging, burning, and tightness.

[0003] In one aspect, the present disclosure is directed to, among other things, a cosmetic composition in the form of an oil-in-water emulsion, preferably a gel emulsion. In one embodiment, the cosmetic composition includes:

[0004] (a) hydroxypropyl tetrahydropyrantriol;

[0005] (b) water;

[0006] (c) one or more non-ionic emulsifiers chosen from glyceryl esters having an HLB of about 3 to about 8;

[0007] (d) one or more nonionic emulsifiers having an HLB of about 16 to about 18 ;

[0008] (e) one or more nonionic emulsifiers having an HLB of about 9 to about 15 ;

[0009] (f) one or more fatty alcohols;

[0010] (g) one or more fatty compounds; and

[0011] (h) one or more thickening polymers.

[0012] wherein all weight percentages are based on the total weight of the cosmetic composition.

[0013] Among the nonionic emulsifiers, non-limiting examples of glyceryl esters having an HLB of about 3 to about 8 include glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl palmitate lactate, glyceryl stearate, glyceryl distearate, glyceryl laurate, or a mixture thereof. In at least one instance the glyceryl ester comprises glyceryl stearate, glyceryl ricinoleate, and mixtures thereof.

[0014] Non-limiting examples of nonionic emulsifiers having an HLB of about 16 to about 18 include ethoxylated emulsifiers, e.g., ethoxylated fatty acids, ethoxylated sorbitan fatty esters, and mixtures thereof. Ethoxylated fatty acids are particularly preferred.

[0015] Non-limiting examples of non-ionic emulsifiers having an HLB of about 9 to about 15 include alkyl polyglucosides (cetearyl glucoside), polyglycerol-based emulsifiers (polyglyceryl-3 methylglucose distearate), sorbitan fatty esters (polysorbate 60), sugar esters or ethers, sugar-based esters or ethers, polyol fatty esters or ethers, glyceryl fatty esters or ethers, ethoxylates thereof, or mixtures thereof.

[0016] Non-limiting examples of fatty alcohols include fatty alcohols having from 8 to 24 carbon atoms, in particular, cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, and mixtures thereof.

[0017] Non-limiting examples of fatty compounds include fatty esters (e.g., isononyl isononanoate), polyolefins (petrolatum), waxes, squalane, squalene, hydrogenated polyisobutene, hydrogenated polydecene, polybutene, mineral oil, pentahydrosqualene, plant and / or vegetable oil (e.g., soybean oil), hydrocarbon-based oils (e.g., isohexadecane), and a mixture thereof.

[0018] Useful thickening polymers include, among others, taurate copolymers. Non-limiting examples include acrylamide / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and mixtures thereof.

[0019] Silicones may optionally be included in the cosmetic compositions but preferably the compositions are free or essentially free of silicones. Silicones are synthetic polymers consisting of repeating units of siloxane, silicon and elemental oxygen, combined with other elements, most often carbon and hydrogen. Thus, silicones are also referred to as polysiloxanes. In some cases, the cosmetic compositions of the present case are free or essentially free of silicones, such as dimethicones, amodimethicones, dimethiconols, cyclosiloxanes, siloxanes, etc.

[0020] In one embodiment, the cosmetic compositions are part of a kit comprising a cosmetic composition according to the present disclosure and one or more separately contained compositions. In one embodiment, the compositions are received in a device, for example, a device that dispenses the cosmetic composition and the one or more separately contained compositions. In one embodiment, the device dispenses the cosmetic composition and the one or more separately contained compositions without mixing them together prior to dispensing. Even though high amounts of hydroxypropyl tetrahydropyrantriol are incorporated into the cosmetic compositions, and optionally, high amounts of tert-butylcyclohexanol, the compositions are unique in that they are compatible with other cosmetic compositions, in particular, other cosmetic compositions for the treatment of the skin.

[0021] Another aspect of the present disclosure relates to methods of stabilizing high amounts of hydroxypropyl tetrahydropyrantriol in cosmetic compositions; and to methods of stabilizing high amounts of tert-butylcyclohexanol in the cosmetic compositions. These methods, as described throughout the disclosure, comprise incorporating high amounts of hydroxypropyl tetrahydropyrantriol, and optionally, high amounts of tert-butylcyclohexanol, into the compositions of the present disclosure.

[0022] Another aspect of the present disclosure relates to methods of treating the skin. The methods include applying the cosmetic composition of the present disclosure to the skin. In one embodiment, the methods reduce the appearance of fine lines and wrinkles, enhance hyaluronic acid production via stimulation of glycosaminoglycan (GAG) synthesis, thereby softening the stratum corneum to relieve cumulative stress on the epidermis and dermis, etc. When tert-butylcyclohexanol is included in the compositions, the methods further treat skin irritation, soothe the skin, and / or reduce or alleviate stinging, burning, and tightness.

[0023] Other features and iterations of the invention are described in more detail below. DETAILED DESCRIPTION

[0024] A common problem associated with the formulation of compositions, particularly a composition comprising multiple components, is ensuring physical stability, chemical stability, solubility, and the like. Many additives for food, cosmetic, personal care, and household products in which they are incorporated are difficult to stabilize and solubilize, particularly when used in high amounts. The consequence of stability and solubility problems is significant. For example, stability problems can cause partial, if not complete, loss of integrity of the product, loss of color, off-odors, changes in viscosity, etc. Stability problems can also cause an increase or decrease in the amount of the component in question to be applied.With active ingredients, stability issues reduce or eliminate activity, and prevent active ingredients from reaching their intended target in the desired amount.

[0025] With aging, the outer layer of the skin (epidermis) thins, although the number of cell layers remains unchanged. The number of pigment-containing cells (melanocytes), however, decreases. As a result, the skin appears pale and translucent. Large pigmented patches (age spots, senile spots, or lentigines) may appear in sun-exposed areas. Changes in connective tissue reduce the skin's firmness and elasticity. This is known as elastosis. It is most pronounced in sun-exposed areas (solar elastosis). Elastosis produces the leathery, weathered appearance common to farmers, fishermen, and others who spend a lot of time outdoors. Dehydration increases the risk of skin damage. Poor nutrition can also negatively affect the skin, causing dryness, rashes, and puffiness.

[0026] Human skin acts as a primary barrier between the body and its environment. Crucial to this barrier function of the skin is the lipid matrix in the outermost layer of the skin (epidermis), the stratum corneum (SC). Two of its functions are (1) to prevent excessive water loss through the epidermis and (2) to prevent environmental compounds from penetrating the viable layers of the epidermis and dermis and thus provoking an immune response. The composition of the SC lipid matrix is ​​dominated by three classes of lipids: cholesterol, free fatty acids, and ceramides. These lipids adopt a highly ordered, three-dimensional structure of densely packed, stacked lipid layers (lipid lamellae): the lateral and lamellar lipid organization. How these lipids are ordered depends on the lipid composition. A very common skin disease in which the SC lipid barrier is affected is atopic dermatitis (AD).

[0027] What is needed, among other things, are compositions which include high amounts of hydroxypropyl tetrahydropyrantriol; and compositions which further include high amounts of 4-tert-cyclohexanol.

[0028] In one aspect, the present disclosure is directed to, among other things, a stable cosmetic composition that includes high amounts of hydroxypropyl tetrahydropyrantriol, and optionally includes high amounts of 4-tert-butylcyclohexanol; and to methods of stabilizing cosmetic compositions containing high amounts of hydroxypropyl tetrahydropyrantriol, and optionally high amounts of 4-tert-butylcyclohexanol. In one embodiment, the compositions include:

[0029] (a) about 10 to about 40% by weight of hydroxypropyl tetrahydropyrantriol;

[0030] (b) water;

[0031] (c) about 0.1 to about 5% by weight of nonionic emulsifier selected from glyceryl esters having an HLB of about 3 to about 8;

[0032] (d) about 0.1 to about 5% by weight of one or more nonionic emulsifiers having an HLB of about 16 to about 18;

[0033] (e) about 0.1 to about 5% by weight of one or more nonionic emulsifiers having an HLB of about 9 to about 15;

[0034] (f) about 1 to about 10% by weight of one or more fatty alcohols;

[0035] (g) about 5 to about 20% by weight of one or more fatty compounds; and

[0036] (h) one or more thickening polymers;

[0037] wherein the composition is in the form of an oil-in-water emulsion, preferably a gel emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

[0038] A gel emulsion is an oil-in-water emulsion, in which the aqueous phase is a gel and the oil droplets / particles are dispersed in the matrix of frost. (a) Hydroxypropyl tetrahydropyrantriol

[0039] Hydroxypropyl tetrapyrantriol is a sugar-protein hybrid made from xylose and can effectively activate the synthesis of GAG (glycosaminoglycans), promote the production of hyaluronic acid, the synthesis of collagen, the adhesion between the dermis and the epidermis, the synthesis of structural components of the epidermis, the regeneration of damaged tissues, and maintain skin elasticity.

[0040] The amount of hydroxypropyl tetrapyrantriol in the cosmetic compositions will vary but in various embodiments is from about 10 wt% to about 40 wt% based on the total weight of the composition. In additional embodiments, the amount of hydroxypropyl tetrapyrantriol in the composition is from about 10 wt% to about 35 wt%, from about 10 to about 30 wt%, from about 10 to about 25 wt%, from about 10 to about 20 wt%, from about 12 to about 35 wt%, from about 12 to about 30 wt%, from about 12 to about 25 wt%, from about 12 to about 20 wt%, from about 12 to about 18% by weight, from about 14 to about 30% by weight, from about 14 to about 25% by weight, from about 14 to about 20% by weight, or from about 14 to about 18% by weight, based on the total weight of the composition, (beautiful

[0041] The amount of water in the cosmetic compositions can and will vary depending on the amount of other components in the cosmetic compositions. Generally, the amount of water in the composition is from about 30 to about 85% by weight, based on the total weight of the cosmetic composition. In various embodiments, the amount of water in the cosmetic composition is from about 30 to about 80% by weight, from about 30 to about 70% by weight, from about 30 to about 60% by weight, from about 30 to about 50% by weight, from about 40 to about 80% by weight, from about 40 to about 70% by weight, from about 40 to about 60% by weight, from about 40 to about 50% by weight, from about 50 to about 80% by weight, from about 50 to about 75% by weight, from about 50 to about 70% by weight, from about 55 to about 85% by weight, from about 55 to about 80% by weight, from about 55 to about 75% by weight, from about 55 to about 70% by weight, from about 60 to about 85% by weight, from about 60 to about 80% by weight, from about 60 to about 75% by weight, or from about 60 to about 70% by weight, based on the total weight of the cosmetic composition.

[0042] (c) Non-ionic emulsifiers / Glyceryl esters

[0043] The cosmetic composition of the present disclosure includes one or more non-ionic emulsifiers selected from glyceryl esters having an HLB of about 3 to about 8. Non-limiting examples include glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl palmitate lactate, glyceryl stearate, glyceryl distearate, or a mixture thereof. Preferred glyceryl esters include glyceryl stearate, glyceryl ricinoleate, or a mixture thereof.

[0044] In various embodiments, the one or more glyceryl esters having an HLB of about 3 to about 8 are selected from glyceryl esters that are solid at a temperature below 30°C.

[0045] The total amount of the one or more nonionic emulsifiers selected from one or more glyceryl esters having an HLB of about 3 to about 8 may vary. In one embodiment, the amount of the nonionic emulsifier selected from one or more glyceryl esters having an HLB of about 3 to about 8 is from 0.1% by weight to about 5% by weight based on the total weight of the cosmetic composition.In additional embodiments, the amount of the nonionic emulsifier selected from one or more glyceryl esters having an HLB of about 3 to about 8 is about 0.1 to about 4 wt%, about 0.1 to about 3 wt%, about 0.1 to about 2 wt%, about 0.2 wt% to about 5 wt%, about 0.2 to about 4 wt%, about 0.2 to about 3 wt%, about 0.2 to about 2 wt%, about 0.3 wt% to about 5 wt%, about 0.3 to about 4 wt%, about 0.3 to about 3 wt%, about 0.3 to about 2 wt%, about 0.5 wt% to about 5 wt%, about 0.5 to about 4% by weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, based on the total weight of the cosmetic composition.

[0046] (d) Nonionic emulsifiers having an HLB of about 16 to about 18

[0047] Non-limiting examples of non-ionic emulsifiers having an HLB of about 16 to about 18 include ethoxylated emulsifiers, e.g., ethoxylated fatty acids, ethoxylated sorbitan fatty esters, and mixtures thereof. In some cases, it is preferred that the non-ionic emulsifiers having an HLB of about 16 to about 18 include one or more ethoxylated fatty acids.

[0048] Non-limiting examples of ethoxylated fatty acids include adducts of ethylene oxide with esters of lauric acid, palmitic acid, stearic acid or behenic acid, and mixtures thereof, in particular those containing from 9 to 100 oxyethylene groups, such as PEG-9 to PEG-50 laurate (according to the INCI names: PEG-9 laurate to PEG-50 laurate); PEG-9 to PEG-50 palmitate (according to the INCI names: PEG-9 palmitate to PEG-50 palmitate); PEG-9 to PEG-50 stearate (according to the INCI names: PEG-9 stearate to PEG-50 stearate); PEG-9 to PEG-50 palmitostearate PEG-50; PEG-9 to PEG-50 behenate (according to INCI names: PEG-9 behenate to PEG-50 behenate); polyethylene glycol 100 EO monostearate (INCI name: PEG-100 stearate); and mixtures thereof.

[0049] Non-limiting examples of ethoxylated sorbitan fatty esters include polysorbate-20 (POE(20) sorbitan monolaurate), polysorbate-21 (POE(4) sorbitan monolaurate), polysorbate-40 (POE(20) sorbitan monopalmitate), polysorbate-60 (POE(20) sorbitan monopalmitate), POE(20) sorbitan), polysorbate-61 (POE(4) sorbitan monostearate), polysorbate-65 (POE(20) sorbitan tristearate), polysorbate-80 (POE(20) sorbitan monooleate), polysorbate-81 (POE(4) sorbitan monooleate), polysorbate 85 (POE(4) sorbitan trioleate POE(20) sorbitan), isostearate of sorbitan, sorbitan monolaurate, sorbitan monooleate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate and sorbitan tristearate and a mixture thereof.

[0050] The total amount of the one or more nonionic emulsifiers having an HLB of about 16 to about 18 will vary. However, in one embodiment, the amount of the one or more nonionic emulsifiers having an HLB of about 16 to about 18 is about 0.1 to about 5% by weight, based on the total weight of the cosmetic composition.In additional embodiments, the amount of the one or more nonionic emulsifiers having an HLB of about 16 to about 18 is in a range of about 0.1 to about 4 wt%, about 0.1 to about 3 wt%, about 0.1 to about 2 wt%, about 0.2 wt% to about 5 wt%, about 0.2 to about 4 wt%, about 0.2 to about 3 wt%, about 0.2 to about 2 wt%, about 0.3 wt% to about 5 wt%, about 0.3 to about 4 wt%, about 0.3 to about 3 wt%, about 0.3 to about 2 wt%, about 0.5 wt% to about 5 wt%, about 0.5 to about 4 wt% weight, from about 0.5 to about 3% by weight, from about 0.5 to about 2% by weight, based on the total weight of the cosmetic composition.

[0051] (e) Nonionic emulsifiers having an HLB of about 9 to about 15

[0052] Non-limiting examples of non-ionic emulsifiers having an HLB of about 9 to about 15 include alkyl polyglucosides (cetearyl glucoside), polyglycerol-based emulsifiers (polyglyceryl-3 methylglucose distearate), sorbitan fatty esters (polysorbate 60), sugar esters or ethers, sugar-based esters or ethers, polyol fatty esters or ethers, glyceryl fatty esters or ethers, ethoxylates thereof, or mixtures thereof.

[0053] In a preferred embodiment, one or more of the nonionic emulsifiers having an HLB of about 9 to about 15 are sugar esters or ethers or sugar-based esters and ethers. “Sugar ester” as used herein means “ester sugar alcohol fatty acid ester” or “sugar alcohol fatty acid ester” and “sugar ether” as used herein means “sugar alcohol fatty alcohol ether”. Sugar-based esters and ethers may be esters or ethers of (a) a sugar, a sugar alcohol, or a sugar derivative and (b) a fatty acid or a fatty alcohol. In some embodiments, esters may be preferred over ethers, and vice versa. Esters and ethers may be formed by combining a sugar, a sugar alcohol, or a sugar derivative with a fatty acid, or by combining a sugar, a sugar alcohol, or a sugar derivative with a fatty alcohol.For example, a sucrose laurate ester may be formed by combining sucrose with an ester of lauric acid or lauryl sucronic acid, and unless otherwise indicated herein, it is not necessary for the present embodiments that a particular ester (or ether) be the result of esterification (or etherification) with a fatty acid as opposed to a fatty alcohol, or vice versa.

[0054] Preferred sugars of the esters and ethers include monosaccharides, disaccharides and oligosaccharides, and in a preferred embodiment, the sugar is a mono-, di- or tri-saccharide, or a mixture thereof. Exemplary sugars include allose, altrose, arabinose, cellobiose, erythrose, erythrulose, fructose, fucose, galactose, gentiobiose, glucose, gulose, idose, isomaltose, lactose, lactulose, lyxose, maltose, maltotriose, mannobiose, mannose, melezitose, raffinose, rhamnose, ribose, ribulose, sorbose, sucrose, talose, threose, trehalose, xylobiose, xylose and xylulose. In a preferred embodiment, the sugar is glucose or sucrose.Exemplary sugar alcohols include allitol, arabitol, ductitol, erythritol, galactitol, glycerol, glycol, iditol, inositol, isomalt, lactitol, mallitol, maltitol, mannitol, sorbitol, and xylitol. Exemplary sugar derivatives such as sulfonated sugars and sugar amines may also be used in the present embodiments. These examples are non-limiting examples, and it is understood that any saccharide, sugar alcohol, or other sugar derivative that will provide a hydrophilic headgroup to the ester or ether and is otherwise pharmaceutically acceptable is suitable for use in the present embodiments.

[0055] The fatty acids and fatty alcohols used in the esters and ethers may be any fatty acid or fatty acid alcohol capable of providing a hydrophobic tail group such that the ester or ether can exert surface-active properties. The fatty acids and fatty alcohols may be short chain (i.e., less than 8 carbon atoms in length), medium chain (i.e., 8 to 14 carbon atoms in length), or long chain (i.e., more than 14 carbon atoms in length). Branched or unbranched fatty acids and fatty alcohols may be used. Non-limiting examples of suitable saturated fatty acids include butyric, caproic, caprylic, capric, lauric, myristic, palmitic, stearic, arachidic, and behenic acids, and non-limiting examples of suitable unsaturated fatty acids include myristoleic, palmitoleic, oleic, linoleic, linolenic, arachidonic, eicosapentaenoic, erucic, and docosahexaenoic acids. Non-limiting examples of suitable linear fatty alcohols include caproyl (caproic), caprylic, capric, lauryl, myristyl, palmityl (cetyl), pahnitol oleyl, stearyl, oleyl, linoleyl, linolenyl, arachidyl, behenyl, erucyl, and lignoceryl alcohols, and non-limiting examples of suitable branched fatty alcohols include isocetyl, isostearyl, and isobehenyl alcohols.

[0056] In a preferred embodiment, the fatty component of the sugar-based ester or ether is a C12 fatty component (e.g., stearic acid, stearyl alcohol, lauric acid, lauryl alcohol, etc.), or a C8 to C18 fatty component. In another embodiment, a mixture of medium and long chain fatty components is preferred, particularly a mixture of C8 to C18 saturated and unsaturated fatty components. In yet another embodiment, a mixture of C8 to C18 saturated and unsaturated fatty acids is preferred. In a different embodiment, the sugar-based ester or ether is a di- or tri-ester of a fatty acid or alcohol, or a di- or tri-ether of a fatty alcohol.

[0057] The sugar-based esters and ethers may be monoesters or monoethers, or may be di-, tri-, or polyesters and ethers, depending on the sugar or sugar alcohol selected for use. In one embodiment, mono- and di-esters, or mono- and di-ethers are preferred. Esterification and etherification may occur at any free hydroxyl group in the sugar or sugar alcohol.

[0058] Mixtures of esters or ethers are also contemplated for use. The mixtures may be modified in a number of ways. For example, a particular ester used in a formulation, such as a sugar monostearate, may comprise a variety of sugar monostearate esters, each esterified at a different hydroxyl group. Or, for example, a sugar stearate may comprise a variety of esters having varying degrees of esterification, e.g., monostearate, distearate, tristearate, etc. Or, in yet another example, a sugar monoacid or sugar diacid may comprise mono- or diesterification with a stearyl alcohol fatty component.In yet another example, a mixture containing a particular ester such as a sugar stearate may contain primarily esters of stearyl acid (or stearyl alcohol), but also contain esters of other fatty components, such as, for example, esters of myristic acid (or myristyl alcohol), etc. In another example . Again, an "ester" can already be a mixture of fatty acids to form the esters, for example the "ester" sucrose cocoate is actually a mixture of esters including the laurate, palmitic, myristic, stearic and caproic esters of sucrose with smaller amounts of other short and long chain fatty acids as well as mixed di- and triesters. These non-limiting examples of mixtures also apply to ethers as well as sugar-based esters.

[0059] Sugar-based esters and ethers may be prepared by any suitable means known in the art, for example, by incubating an aqueous mixture of a sugar or sugar alcohol, a fatty acid, and a catalytically active amount of a lipolytic enzyme, and recovering the resulting ester from the mixture. Other methods include mixing the sugar with a fatty acid chloride at about 80°C, with simple removal of the hydrogen chloride formed, and recovering the sugar fatty acid ester. Similarly, a mixture of a methyl fatty acid ester and sugar may be heated to a temperature of about 90°C in the presence of a base catalyst, distilling the methanol formed, and recovering the sugar fatty acid ester. Many suitable esters and ethers are also commercially available.

[0060] The fatty acid esters of sugars may be chosen in particular from the group comprising esters or mixtures of esters of C8-C22 fatty acids and sucrose, maltose, glucose or fructose, and esters or mixtures of esters of C14-C22 fatty acids and methylglucose.

[0061] The C8-C22 or C14-C22 fatty acids forming the fatty unit of the esters which may be used comprise a linear, saturated or unsaturated alkyl or alkenyl chain containing, respectively, from 8 to 22 or from 14 to 22 carbon atoms. The fatty unit of the esters may be chosen in particular from stearates, behenates, arachidonates, palmitates, myristates, laurates and caprates, and mixtures thereof. Stearates are preferably used.

[0062] As examples of esters or mixtures of esters of fatty acids and sucrose, maltose, glucose or fructose, mention may be made of sucrose monostearate, sucrose distearate and sucrose tristearate and mixtures thereof; and examples of esters or mixtures of esters of fatty acids and methylglucose which may be mentioned are polyglyceryl-3 methylglucose distearate. Mention may also be made of monoesters of glucose or maltose such as methyl o-hexadecanoyl-6-D-glucoside and o-hexadecanoyl-6-D-maltoside.

[0063] In one embodiment, the cosmetic composition preferably includes at least one ester of C14-C22 fatty acids and methylglucose, for example, polyglyceryl-3 methylglucose distearate.

[0064] The fatty alcohol ethers of sugars which can be used can be solid at a temperature less than or equal to 45°C and can be chosen in particular from the group comprising ethers or mixtures of ethers of C8-C22 fatty alcohol and glucose, maltose, sucrose or fructose, and ethers or mixtures of ethers of a C14-C22 fatty alcohol and methylglucose. These are in particular alkyl polyglucosides, which in various embodiments are preferred. A particularly preferred example is C12-20 alkyl glucoside. Accordingly, in one embodiment, the cosmetic compositions include at least one alkyl polyglucoside, for example, a C12-20 alkyl glucoside.

[0065] The C8-C22 or C14-C22 fatty alcohols forming the fatty unit of the ethers which may be used comprise a linear, saturated or unsaturated alkyl or alkenyl chain containing, respectively, from 8 to 22 or from 14 to 22 carbon atoms. The fatty unit of the ethers may be chosen in particular from the decyl, cetyl, behenyl, arachidyl, stearyl, palmityl, myristyl, lauryl, capryl and hexadecanoyl units, and mixtures thereof, such as cetearyl.

[0066] As examples of fatty alcohol ethers of sugars, mention may be made of alkylpolyglucosides such as decylglucoside and laurylglucoside, cetostearyl glucoside, arachidyl glucoside, and mixtures thereof. Further mentioned are sucrose monostearate, sucrose distearate or sucrose tristearate and mixtures thereof, polyglyceryl-3 methylglucose distearate and alkylpolyglucosides.

[0067] In some embodiments, the non-ionic emulsifiers having an HLB of about 9 to about 15 may be selected from: polyglyceryl fatty acid esters of at least one fatty acid comprising at least one saturated or unsaturated, linear or branched, C8-C22 hydrocarbon group, such as a C8-C22 alkyl or alkenyl group, preferably a C8-C18 alkyl or alkenyl group, and more preferably a C8-C12 alkyl or alkenyl group, and from 2 to 12 glycerols, preferably from 2 to 10 glycerols and more preferably from 2 to 8 glycerols; polyoxyethylenated alkyl glycerides such as polyethylene glycol derivatives of a mixture of mono-, di- and tri-glycerides of caprylic and capric acids (preferably 2 to 30 ethylene oxide units, more preferably 2 to 20 ethylene oxide units, and even more preferably 2 to 10 ethylene oxide units);polyoxyethylenated fatty ethers of at least one, preferably one, fatty alcohol comprising at least one C8-C22 hydrocarbon group, saturated or unsaturated, linear or branched, such as a C8-C22 alkyl or alkenyl group, preferably a C8-C18 alkyl or alkenyl group, and more preferably a C8-C12 alkyl or alkenyl group, and from 2 to 60 ethylene oxides, preferably from 2 to 30 ethylene oxides, and more preferably from 2 to 10 ethylene oxides; and mixtures thereof. ;

[0068] It is preferable that the polyglyceryl fatty acid ester has a polyglycerol group derived from 2 to 10 glycerols, more preferably from 2 to 8 glycerols, and even more preferably from 4 to 6 glycerols. The polyglyceryl fatty acid ester may be selected from mono, di and triesters of saturated or unsaturated acid, preferably of saturated acid, including 8 to 22 carbon atoms, preferably 8 to 18 carbon atoms, and more preferably 8 to 12 carbon atoms, such as caprylic acid, capric acid, lauric acid, oleic acid, stearic acid, isostearic acid and myristic acid.

[0069] The polyglyceryl fatty acid ester may be selected from the group consisting of PG2 caprate, PG2 dicaprate, PG2 tricaprate, PG2 caprylate, PG2 dicaprylate, PG2 tricaprylate, PG2 laurate, PG2 dilaurate, PG2 trilaurate, PG2 myristate, PG2 dimyristate, PG2 trimyristate, PG2 stearate, PG2 distearate, PG2 tristearate, PG2 isostearate, PG2 diisostearate, PG2 triisostearate, PG2 oleate, PG2 dioleate, PG2 trioleate, PG3 caprate, PG3 dicaprate, PG3 tricaprate, PG3 caprylate, PG3 dicaprylate, PG3 tricaprylate, PG3 laurate, PG3 dilaurate, PG3 trilaurate, PG3 myristate, PG3 dimyristate, PG3 trimyristate, PG3 stearate, PG3 distearate, PG3 tristearate, PG3 isostearate, PG3 diisostearate, PG3 triisostearate, PG3 oleate, PG3 dioleate,PG3 trioleate, PG4 caprate, PG4 dicaprate, PG4 tricaprate, PG4 caprylate, PG4 dicaprylate, PG4 tricaprylate, PG4 laurate, PG4 dilaurate, PG4 trilaurate, PG4 myristate, PG4 dimyristate, PG4 trimyristate, PG4 stearate, PG4 distearate, PG4 tristearate, PG4 isostearate, PG4 diisostearate, PG4 triisostearate, PG4 oleate, PG4 dioleate, PG4 trioleate, PG5 caprate, PG5 dicaprate, PG5 tricaprate PG5, PG5 caprylate, PG5 dicaprylate, PG5 tricaprylate, PG5 laurate, PG5 dilaurate, PG5 trilaurate, PG5 myristate, PG5 dimyristate, PG5 trimyristate, PG5 stearate, PG5 distearate, PG5 tristearate PG5, PG5 isostearate, PG5 diisostearate, PG5 triisostearate, PG5 oleate, PG5 dioleate, PG5 trioleate, PG6 caprate, PG6 dicaprate,PG6 tricaprate, PG6 caprylate, PG6 dicaprylate, PG6 tricaprylate, PG6 laurate, PG6 dilaurate, PG6 trilaurate, PG6 myristate, PG6 dimyristate, PG6 trimyristate, PG6 stearate, PG6 distearate, PG6 tristearate, PG6 isostearate, PG6 diisostearate, PG6 triisostearate, PG6 oleate, PG6 dioleate, PG6 trioleate, PG10 caprate, PG10 dicaprate, PG10 tricaprate, PG10 caprylate, PG10 dicaprylate, PG10 tricaprylate, PG 10 laurate, PG 10 dilaurate, PG 10 trilaurate, PG 10 myristate, PG 10 dimyristate, PG 10 trimyristate, PG 10 stearate, distearate, PG10, PG10 tristearate, PG10 isostearate, PG10 diisostearate, PG10 triisostearate, PG10 oleate, PG10 dioleate, PG10 trioleate, and mixtures thereof.

[0070] The polyoxyalkylenated fatty ethers, preferably polyoxyethylenated fatty ethers, may comprise from 2 to 60 ethylene oxide units, preferably from 2 to 30 ethylene oxide units, and more preferably from 2 to 10 ethylene oxide units. The fatty chain of the ethers may be chosen in particular from lauryl, behenyl, arachidyl, stearyl and cetyl units, and mixtures thereof, such as cetearyl. Examples of ethoxylated fatty ethers that may be mentioned are lauryl alcohol ethers comprising 2, 3, 4 and 5 ethylene oxide units (CTFA names: Laureth-2, Laureth-3, Laureth-4 and Laureth-5).

[0071] The mixed esters of fatty acids, or fatty alcohol, carboxylic acid and glycerol, which can be used as the above non-ionic surfactant, may be chosen in particular from the group comprising mixed esters of fatty acid or fatty alcohol with an alkyl or alkenyl chain containing from 8 to 22 carbon atoms, preferably from 8 to 18 carbon atoms, and more preferably from 8 to 12 carbon atoms, and of alpha-hydroxy acid and / or succinic acid, with glycerol. The alpha-hydroxy acid may be, for example, citric acid, lactic acid, glycolic acid or malic acid, and mixtures thereof.

[0072] The alkyl chain of the fatty acids or alcohols from which the mixed esters that can be used are derived may be linear or branched, and saturated or unsaturated. In particular, they may be stearate, isostearate, linoleate, oleate, behenate, ara-chidonate, palmitate, myristate, laurate, caprate, isostearyl, stearyl, linoleyl, oleyl, behenyl, myristyl, lauryl or capryl chains, and mixtures thereof.Non-limiting examples of mixed esters include the mixed ester of glycerol and the mixture of citric acid, lactic acid, linoleic acid and oleic acid (CTFA name: Glyceryl citrate / lactate / linoleate / oleate); the mixed ester of succinic acid and isostearyl alcohol with glycerol (CTFA name: Isostearyl diglyceryl succinate); the mixed ester of citric acid and stearic acid with glycerol (CTFA name: Glyceryl stearate citrate); the mixed ester of lactic acid and stearic acid with glycerol (CTFA name: Glyceryl stearate lactate), and mixtures thereof.

[0073] The sorbitan fatty esters and the oxyalkylenated sorbitan fatty esters may be selected from the group comprising C16-C22 sorbitan fatty acid esters and oxyethylenated C16-C22 sorbitan fatty acid esters. They may be formed from at least one fatty acid comprising at least one saturated linear alkyl chain containing, respectively, from 16 to 22 carbon atoms, and from sorbitol or ethoxylated sorbitol. The oxyethylenated esters may generally comprise from 1 to 100 ethylene units. glycol and preferably from 2 to 40 ethylene oxide (EO) units. These esters may be chosen in particular from stearates, behenates, arachidates, palmitates, and mixtures thereof. Stearates and palmitates are preferably used. Non-limiting examples include sorbitan monostearate (CTFA name: sorbitan stearate), sorbitan monopalmitate (CTFA name: sorbitan palmitate), sorbitan tristearate 20 EO (CTFA name: polysorbate 65), and mixtures thereof.

[0074] The block copolymers of ethylene oxide (A) and propylene oxide (B) which can be used can be chosen in particular from block copolymers of formula

[0075] HO(C2H4O)x(C3H6O)y(C2H4O)zH

[0076] wherein x, y and z are integers such that x + z is in a range of 2 to 100 and y is in a range of 14 to 60, and mixtures thereof.

[0077] The polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C16-C30) ethers, which can be used as the above nonionic surfactant, can be selected from PPG-6 decyltetradeceth-30; polyoxyethylene (30) polyoxypropylene (6) tetradecyl ether; PPG-6 decyltetradeceth-12; polyoxyethylene (12) polyoxypropylene (6) tetradecyl ether; PPG-13 decyltetradeceth-24; polyoxyethylene (24) polyoxypropylene (13) decyltetradeceth-20; polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, PPG-4 ceteth-1; polyoxyethylene (1) polyoxypropylene (4) cetyl ether, PPG-8 ceteth-1; polyoxyethylene (1) polyoxypropylene (8) cetyl ether, PPG-40 ceteth-1; polyoxyethylene (10) polyoxypropylene (4) cetyl ether, PPG-4 ceteth-20;polyoxyethylene (20) polyoxypropylene (4) cetyl ether, PPG-5 ceteth-20; polyoxyethylene (20) polyoxypropylene (5) cetyl ether, PPG-8 ceteth-20; polyoxyethylene (20) polyoxypropylene (8) cetyl ether, and PPG-23 steareth-34; polyoxyethylene polyoxypropylene (34 EO) stearyl ether (23 PO). ;

[0078] In various embodiments, it may be more preferable that the polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) (C16-C30) alkyl ethers are polyoxypropylenated (15-40 EO) and polyoxypropylenated (5-30 PO) (C16-C24) alkyl ethers, which may be selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34. It may be even more preferable that the polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) (C16-C30) alkyl ethers are polyoxypropylenated (15-40 EO) and polyoxypropylenated (5-30 PO) (C16-C24) alkyl ethers, which may be selected from the group consisting of PPG-6 decyltetradeceth-30, PPG-13 decyltetradeceth-24, PPG-5 ceteth-20 and PPG-8 ceteth-20.

[0079] In one embodiment, the one or more nonionic emulsifiers having an HLB of 9 to 12 may be selected from alkylpolyglucosides (e.g., C12-20 alkyl glucoside), polyglyceryl-10 laurate, polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-2 polyhydroxystearate, polyglyceryl-3 caprylate, polyglyceryl-3 laurate, polyglyceryl-3 methylglucose distearate, polyglyceryl-3 oleate, polyglyceryl-3 palmitate, polyglyceryl-3 polyricinoleate, polyglyceryl-3 ricinoleate, polyglyceryl-5 laurate, polyglyceryl-6 dicaprate, polyglyceryl-6 oleate, polyglyceryl-6 stearate, and a mixture of these.

[0080] The total amount of the one or more nonionic emulsifiers having an HLB of about 9 to about 15 will vary. However, in various embodiments, the amount of the one or more nonionic emulsifiers having an HLB of about 9 to about 15 is from about 0.1 to about 5% by weight, based on the total weight of the cosmetic composition.In additional embodiments, the one or more nonionic emulsifiers having an HLB of about 9 to about 15 is about 0.1 to about 4 wt%, about 0.1 to about 3 wt%, about 0.1 to about 2 wt%, about 0.3 to about 5 wt%, about 0.3 to about 4 wt%, about 0.3 to about 2 wt%, about 0.5 to about 5 wt%, about 0.5 to about 4 wt%, about 0.5 to about 3 wt%, or about 0.5 to about 2 wt%, about 1.0 to about 5 wt%, about 1.0 to about 4 wt%, about 1.0 to about 3 wt%, or about 1.0 to about 2 wt% by weight, based on the total weight of the cosmetic composition. (0 Fatty alcohols

[0081] The term "fatty alcohol" denotes an alcohol comprising at least one hydroxyl group (OH), and comprising at least 8 carbon atoms, preferably at least 12 carbon atoms and which is neither oxyalkylenated (in particular neither oxyethylenated nor oxypropylenated) nor glycerolated. Fatty alcohols may be represented by: R-OH, in which R denotes a saturated (alkyl) or unsaturated (alkenyl) group, linear or branched, comprising from 8 to 40 carbon atoms, preferably from 10 to 30 carbon atoms, more preferably from 12 to 24 carbon atoms, and even more preferably from 14 to 22 carbon atoms.

[0082] The fatty alcohol(s) may be liquid or solid. In some embodiments, it is preferable that the cosmetic compositions include at least one solid fatty alcohol, particularly saturated fatty alcohols that are solid at 25°C, preferably having at least 12 carbon atoms.

[0083] Solid fatty alcohols that may be used include those that are solid at room temperature and atmospheric pressure (25°C, 780 mmHg), and are insoluble in water, namely they have a solubility in water of less than 1% by weight, preferably less than 0.5% by weight, at 25°C, 1 atm.

[0084] In one embodiment, the solid fatty alcohols are represented by: R-OH, wherein R denotes a linear alkyl group, optionally substituted by one or more hydroxyl groups, comprising from 8 to 40 carbon atoms, preferably from 10 to 30 carbon atoms, more preferably from 12 to 24 carbon atoms, and even more preferably from 14 to 22 carbon atoms.

[0085] Non-limiting examples of useful fatty alcohols include lauryl alcohol or lauryl alcohol (1-dodecanol); myristyl alcohol or myristyl alcohol (1-tetradecanol); cetyl alcohol (1-hexadecanol); stearyl alcohol (1-octadecanol); arachidyl alcohol (1-eicosanol); behenyl alcohol (1-docosanol); lignoceryl alcohol (1-tetracosanol); ceryl alcohol (1-hexacosanol); montanyl alcohol (1-octacosanol); myricyl alcohol (1-triacontanol), and mixtures thereof.

[0086] In some embodiments, the one or more fatty alcohols have from 12 to 24 carbon atoms. Specific non-limiting examples include cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, lignoceryl alcohol, or mixtures thereof.

[0087] Preferably, the cosmetic composition includes one or more solid fatty alcohols, for example, selected from cetyl alcohol, stearyl alcohol, behenyl alcohol and mixtures thereof, preferably cetyl alcohol, behenyl alcohol, cetearyl alcohol, and mixtures thereof.

[0088] In some cases, the cosmetic compositions include one or more fatty alcohols selected from decyl alcohol, undecyl alcohol, dodecyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, isocetyl alcohol, behenyl alcohol, linalool, oleyl alcohol, myricyl alcohol and a mixture thereof. In some cases, the cosmetic compositions preferably include cetyl alcohol, behenyl alcohol, and cetearyl alcohol.

[0089] The total amount of the one or more fatty alcohols will vary. However, in various embodiments, the total amount of the one or more fatty alcohols in the cosmetic compositions is from 1% by weight to about 10% by weight, based on the total weight of the composition. In additional embodiments, the total amount of one or more fatty alcohols in the composition is in a range of from about 1 to about 8% by weight, from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight, based on the total weight of the composition. (g) Fatty compounds

[0090] The term "fatty compounds" is interchangeable with "fats." Fatty compounds are known as compounds that are not soluble (or only sparingly soluble) in water; they are hydrophilic and are often solubilized in organic solvents. They include materials such as oils, fats, waxes, hydrocarbons, fatty esters, etc. For the purposes of this disclosure, "fatty compounds" do not include fatty acids, which are referred to separately above. In addition, silicones are not considered fatty compounds according to this disclosure. Non-limiting examples of useful fatty compounds include oils, waxes, alkanes (paraffins), fatty acids, fatty esters, triglyceride compounds, lanolin, hydrocarbons, derivatives thereof, and mixtures thereof.Fatty compounds are described by the International Federation of Societies of Cosmetic Chemists, for example, in Cosmetic Raw Material Analysis and Quality, Volume I: Hydrocarbons, Glycerides, Waxes and Other Esters (Redwood Books, 1994), which is incorporated herein by reference in its entirety.

[0091] Non-limiting examples of fatty compounds include oils, mineral oil, alkanes (paraffins), fatty acids, fatty alcohol derivatives, fatty acid derivatives, fatty alcohol esters, hydroxy-substituted fatty acids, waxes, triglyceride compounds, lanolin, and a mixture thereof.

[0092] Fatty alcohol derivatives

[0093] In one embodiment, the fatty compounds include one or more fatty alcohol derivatives, which are different from fatty alcohols (component (d)). Fatty alcohol derivatives include fatty esters derived from one or more fatty alcohols. Fatty alcohol derivatives also include alkoxylated fatty alcohols, for example, having from about 1 to about 100 moles of an alkylene oxide per mole of alkoxylated fatty alcohol. For example, the alkoxylated fatty alcohols may be alkoxylated with from about 1 to about 80 moles, from about 2 to about 50, from about 5 to about 45 moles, from about 10 to about 40 moles, or from 15 to about 35 moles, including all ranges and subranges therebetween, of an alkylene oxide per mole of alkoxylated fatty alcohol.

[0094] As examples of alkoxylated fatty alcohols, a steareth (e.g., steareth-2, steareth-20, and steareth-21), a laureth (e.g., laureth-4 and laureth-12), a ceteth (e.g., ceteth-10 and ceteth-20), and a ceteareth (e.g., ceteareth-2, ceteareth-10, and ceteareth-20) are mentioned. In at least one instance, the one or more alkoxylated fatty alcohols include steareth-20. In some instances, the one or more alkoxylated fatty alcohols may be exclusively steareth-20.

[0095] Additional fatty alcohol derivatives that may optionally be suitable include methyl stearyl ether; 2-ethylhexyl dodecyl ether; stearyl acetate; cetyl propionate; the ceteth series of compounds, such as ceteth-1 to ceteth-45, which are ethylene glycol ethers of cetyl alcohol, in which the numerical designation indicates the number of ethylene glycol groups present; the series of steareth compounds such as steareth-1 to 10, which are ethylene glycol ethers of steareth alcohol, in which the numerical designation indicates the number of ethylene glycol groups present; ceteareth-1 to ceteareth-10, which are ethylene glycol ethers of ceteareth alcohol, namely a mixture of fatty alcohols containing mainly cetyl and stearyl alcohol, in which the numerical designation indicates the number of ethylene glycol groups present; the C1-C30 alkyl ethers of the ceteth, steareth and ceteareth compounds just described; polyoxyethylene ethers of branched alcohols such as octyldodecyl alcohol, dodecylpentadecyl alcohol, hexyldecyl alcohol and isostearyl alcohol; polyoxyethylene ethers of behenyl alcohol;PPG ethers such as PPG-9-steareth-3, PPG-11 stearyl ether, PPG-8-ceteth-1 and PPG-10 cetyl ether; and a mixture thereof. ;

[0096] Fatty acids

[0097] In one embodiment, the fatty compounds are selected from fatty acids, fatty acid derivatives, fatty acid esters, hydroxyl-substituted fatty acids, and alkoxylated fatty acids. The fatty acids may be straight or branched chain acids and / or may be saturated or unsaturated. Non-limiting examples of fatty acids include dibasic, tribasic, and other multiple acids, as well as salts of these fatty acids. For example, the fatty acid may optionally include or be selected from lauric acid, palmitic acid, stearic acid, behenic acid, arichidonic acid, oleic acid, isostearic acid, sebacic acid, and a mixture thereof. In some cases, the fatty acids are selected from the group consisting of palmitic acid, stearic acid, and a mixture of these.

[0098] Non-limiting examples of polyglycerol esters of fatty acids include those of the following formula: OR2 R^OCH2-CH-CH2O)n-R3

[0099] wherein the average value of n is about 3 and R1, R2 and R3 may each independently be a fatty acid group or hydrogen, provided that at least one of R1, R2 and R3 is a fatty acid group. For example, R1, R2 and R3 may be saturated or unsaturated, straight or branched, and have a length of C1-C40, CrC30, CrC25, or CrCzo, CrC16 or CrC10.

[0100] Fatty acid derivatives are defined herein as including fatty acid esters of fatty alcohols as defined above, fatty acid esters of fatty alcohol derivatives as defined above when such fatty alcohol derivatives have a hydroxyl group esterifiable, fatty acid esters of alcohols other than the fatty alcohols and fatty alcohol derivatives described above, hydroxy-substituted fatty acids, and a mixture thereof.Non-limiting examples of fatty acid derivatives include ricinoleic acid, glycerol monostearate, 12-hydroxy stearic acid, ethyl stearate, cetyl stearate, cetyl palmitate, polyoxyethylene cetyl ether stearate, polyoxyethylene stearyl ether stearate, polyoxyethylene lauryl ether stearate, ethylene glycol monostearate, polyoxyethylene monostearate, polyoxyethylene distearate, propylene glycol monostearate, propylene glycol distearate, trimethylolpropane distearate, sorbitan stearate, glyceryl polystearate, dimethyl sebacate, cocoate PEG-15, PPG-15 stearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, PEG-8 laurate, PPG-2 isostearate, PPG-9 laurate, and a mixture thereof.Preferred for use herein are glycerol monostearate, 12-hydroxy stearic acid, and a mixture thereof.

[0101] Waxes

[0102] The fatty compounds may, in certain cases, include or be chosen from one or more waxes. Non-limiting examples of waxes in this category include, for example, synthetic wax, ceresin, paraffin, ozokerite, polyethylene waxes, illipe butter, beeswax, carnauba, microcrystalline, lanolin, lanolin derivatives, candelilla, cocoa butter, shellac wax, spermaceti, furfural, kapok wax, sugarcane wax, lignite wax, whale wax, bayberry wax, Acacia decurrens flower wax, vegetable waxes (such as sunflower (helianthus annuus) seed wax, carnauba, candelilla, ouricury or Japan wax or cork fiber or sugarcane waxes), or a mixture thereof.

[0103] Oils

[0104] In some cases, the fatty compounds may include or be selected from one or more oils. Suitable oils include, but are not limited to, natural oils, such as coconut oil; hydrocarbons, such as mineral oil and hydrogenated polyisobutene; fatty alcohols, such as octyldodecanol; esters, such as C12-C15 alkyl benzoate; diesters, such as propylene dipelarganate; and triesters, such as glyceryl trioctanoate. Non-limiting examples of oils that may optionally be included in cosmetic compositions include isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinoleate, cetyl stearate, cetyl myristate, coco-dicaprylate / caprate, decyl isostearate, isodecyl oleate, neopentanoate isodecyl, isohexyl neopentanoate, octyl palmitate, dioctyl malate, tridecyl octanoate, myristyl myristate, octododecanol, or combinations of octyldodecanol, acetylated lanolin alcohol, cetyl acetate, isododecanol, polyglyceryl-3-diisostearate, castor oil, lanolin and lanolin derivatives, triisocetyl citrate, sorbitan sesquioleate, C10-C18 triglycerides, caprylic / capric triglycerides, coconut oil, corn oil, cottonseed oil, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, illipe butter, rapeseed oil, soybean oil, sunflower seed oil, tallow, tricaprin, trihydroxystearin, triisostearin, trilaurin, trilinolein, trimyristin, triolein, tripalmitin,tristearin, walnut oil, wheat germ oil, cholesterol, or combinations thereof.

[0105] In some embodiments, the cosmetic composition may include one or more fatty compounds selected from fatty esters (such as isononyl isononanoate), polyolefins (such as petrolatum), waxes, squalane, squalene, hydrogenated polyisobutene, hydrogenated polydecene, polybutene, mineral oil, pentahydrosqualene, plant and / or vegetable oil, hydrocarbon-based oils (such as isohexadecane), or a mixture thereof.

[0106] The total amount of the one or more fatty compounds in the cosmetic compositions will vary. However, in various embodiments, the total amount of the one or more fatty compounds is from about 5 wt% to about 20 wt%, based on the total weight of the cosmetic composition. In additional embodiments, the total amount of the one or more fatty compounds in the cosmetic compositions is from about 5 to about 15 wt%, from about 5 to about 12 wt%, from about 6 to about 20 wt%, from about 6 to about 15 wt%, from about 6 to about 12 wt%, based on the total weight of the cosmetic composition. (h) Thickening polymers

[0107] The cosmetic composition of the present disclosure may optionally include one or more thickening polymers. Non-limiting examples of various types of thickening polymers include a taurate copolymer, a polyacrylate, a polymethacrylate, a polyethylacrylate, a polyacrylamide, a polyC10-30 alkyl acrylate, an acrylic acid / acryloazotes copolymer, an acrylates / steareth-20 itaconate copolymer, an acrylates / ceteth-20 itaconate copolymer, an acrylates / aminoacrylates / PEG-20 C10-30 alkyl itaconate copolymer, an acrylates / aminoacrylates copolymer, an acrylates / steareth-20 methacrylate copolymer, an acrylates / beheneth-25 methacrylate copolymer, an acrylates / ... crosslinked acrylates / steareth-20 methacrylate, crosslinked acrylates / beheneth-25 methacrylate / HEMA copolymer, crosslinked acrylates / vinyl neodecanoate copolymer, crosslinked acrylates / vinyl isodecanoate copolymer, crosslinked acrylates / palmeth-25 acrylate copolymer, acrylic acid / acrylamidomethyl propane sulfonic acid copolymer, and crosslinked acrylates / C10-C30 alkyl acrylate copolymer, carbomers, hydrophobically modified polypolyacrylates; hydrophobically modified polyacrylic acids, hydrophobically modified polyacrylamides;hydrophobically modified polyethers wherein such materials may have a hydrophobic group which may be selected from cetyl, stearyl, oleayl, and combinations thereof, acrylamide / ammonium acrylate copolymer, acrylates copolymer, acrylates cross-linked copolymer-4, acrylates cross-linked copolymer-3, acrylates / beheneth-25 methacrylate copolymer, acrylates / C10-C30 alkyl acrylate cross-linked copolymer, acrylates / steareth-20 itaconate copolymer, poly-ammonium acrylate / isohexadecane / PEG-40 castor oil; sodium carbomer, crosslinked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, crosslinked polyacrylate copolymer-6, polyamide-3, polyquaternium-37, sodium polyacrylate, and a mixture thereof. ;

[0108] Examples of non-ionic thickening polymers include:

[0109] (1) Celluloses modified by groups comprising at least one chain fatty; examples that may be mentioned include: hydroxyethylcelluloses modified with groups comprising at least one fatty chain, such as alkyl, arylalkyl or alkylaryl groups, or mixtures thereof, and in which the alkyl groups are preferably C8-C22, for example the product NATROSOL PLUS GRADE 330 CS (C16 alkyls) sold by the company Aqualon, or the product BERMOCOLL EHM 100 sold by the company Berol Nobel; and hydroxyethylcelluloses modified with alkylphenyl polyalkylene glycol ether groups, such as the product AMERCELL POLYMER HM-1500 (nonylphenyl ether of polyethylene glycol (15)) sold by the company Amerchol,

[0110] (2) Hydroxypropyl guars modified by groups comprising at least one fatty chain, such as the product ESAFLOR HM 22 (C22 alkyl chain) sold by the Lamberti company, and the products RE210-18 (C14 alkyl chain) and RE205-1 (C2o alkyl chain) sold by the Rhone-Poulenc company,

[0111] (3) Copolymers of vinylpyrrolidone and hydrophobic chain monomers fatty; examples that may be mentioned include: ANTARON V216 or GANEX V216 products (vinylpyrrolidone / hexadecene copolymer) sold by the ISP company, ANTARON V220 or GANEX V220 products (vinylpyrrolidone / hexadecene copolymer) nylpyrrolidone / eicosene) sold by the company ISP,

[0112] (4) Copolymers of C1-C6 alkyl methacrylates or acrylates and amphiphilic monomers comprising at least one fatty chain, for example the methyl acrylate / oxyethylenated stearyl acrylate copolymer sold by the company Goldschmidt under the name ANTIL 208,

[0113] (5) Copolymers of hydrophilic methacrylates or acrylates and monomers hydrophobic comprising at least one fatty chain, for example polyethylene glycol methacrylate / lauryl methacrylate copolymer,

[0114] (6) Polyurethane polyethers comprising in their chain both hy drophils usually of polyoxyethylenated nature and hydrophobic blocks, which can be aliphatic sequences alone and / or cycloaliphatic and / or aromatic sequences.

[0115] In a preferred embodiment, the cosmetic composition includes one or more taurate copolymers. These copolymers can act as gelling agents, thickeners, and provide emulsification properties. In particular, the inventors have discovered that the taurate copolymers are particularly effective in stabilizing the cosmetic compositions of the present disclosure.

[0116] Non-limiting examples of taurate copolymers include acrylamide / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and a mixture thereof.

[0117] The taurate copolymers may be hydrophilic and may contain an acrylate component. The at least one taurate copolymer may include, for example, an acrylamide / sodium acryloyl dimethyl taurate copolymer, a hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, and / or a sodium acrylate / sodium acryloyl dimethyl taurate copolymer. In some cases, at least one taurate copolymer may be obtained from ethylenically unsaturated sulfo-functional monomers and ethylenically unsaturated hydrophilic monomers, for example, from crosslinked anionic copolymers of acrylamide or methacrylamide and 2-acrylamido-2-methyl-propanesulfonic acid.

[0118] In some cases, the one or more taurate copolymers may be selected from an acrylamide / sodium acryloyl dimethyl taurate copolymer, a hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, an ammonium acryloyldimethyl taurate / VP copolymer, and mixtures thereof. Further, in some cases, the cosmetic compositions may include both a hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer and an ammonium acryloyldimethyl taurate / VP copolymer, and optionally further include a poly C10-30 alkyl acrylate.

[0119] Generally, the amount of the one or more thickening polymers will vary depending on the type of thickening polymers used; and depending on the desired viscosity of the cosmetic composition. Therefore, in one embodiment, the total amount of the one or more thickening agents is sufficient to achieve the viscosities indicated throughout the present disclosure. Nevertheless, in various embodiments, the total amount of the one or more thickening polymers may be in a range of about 1 to about 8% by weight, based on the total weight of the cosmetic composition. In various embodiments, the amount of the one or more thickening polymers may be in a range of about 1 to about 6% by weight, about 1 to about 5% by weight, about 1 to about 3% by weight, based on the total weight of the cosmetic composition. (i) 4-tert-Butylcyclohexanol

[0120] The cosmetic compositions of the present disclosure do not necessarily require or include 4-tert-butylcyclohexanol - it is optional. However, in various embodiments it is preferable to include 4-tert-butylcyclohexanol. The 4-tert-butylcyclohexanol may be in a cis configuration, a trans configuration, or a mixture of cis and trans configurations. Among other things, 4-tert-butylcyclohexanol is useful for reducing skin irritation, for soothing the skin, and / or for reducing or alleviating stinging, burning, and tightness.

[0121] The total amount of 4-tert-butylcyclohexanol will vary. However, in various embodiments, the total amount of 4-tert-butylcyclohexanol in the cosmetic composition is from about 0.1% by weight to about 5% by weight based on the total weight of the cosmetic composition. In additional embodiments, the total amount of 4-tert-butylcyclohexanol is about 0.1 to about 4 wt%, about 0.1 to about 3 wt%, about 0.1 to about 2 wt%, about 0.5 to about 5 wt%, about 0.5 to about 4 wt%, about 0.5 to about 3 wt%, about 0.5 to about 2 wt%, about 1 to about 5 wt%, about 1 to about 4 wt%, about 1 to about 3 wt% or about 1 to about 2 wt%, based on the total weight of the cosmetic composition. (j) Water-soluble solvents

[0122] The term "water-soluble solvent" is interchangeable with the term "water-miscible solvent" and means a compound that is liquid at 25°C and atmospheric pressure (760 mmHg), and has a solubility of at least 50% in water in these conditions. In some cases, the water-soluble solvents have a solubility of at least 60%, 70%, 80%, or 90%. Non-limiting examples of one or more water-soluble solvents are selected from glycerin, monohydric alcohols, polyols (polyhydric alcohols), glycols, and a mixture thereof.

[0123] As examples of organic solvents, mention may be made, in a non-limiting manner, of monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, isopropyl alcohol, benzyl alcohol, 4-tert-butylcyclohexanol and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin. Organic solvents can be volatile or non-volatile compounds.

[0124] Additional non-limiting examples of water-soluble solvents include alkanediols (polyhydric alcohols) such as glycerin, 1,2,6-hexanetriol, tri-methylolpropane, ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, (caprylyl glycol), 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1,2-pentanediol; alkyl alcohols having 1 to 4 carbon atoms such as ethanol, methanol, butanol, propanol and isopropanol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether,ethylene glycol monoisopropyl ether, diethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-l-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether and dipropylene glycol monoisopropyl ether; 2-pyrrolidone, N-methyl-2-pyrrolidone, l,3-dimethyl-2-imidazolidinone, formamide, acetamide, dimethyl sulfoxide, , sorbit, sorbitan, acetin, diacetin, triacetin, sulfolane, and a mixture thereof.

[0125] Polyhydric alcohols are also useful. Examples of polyhydric alcohols include glycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, and a mixture thereof. Polyol compounds may also be used. Non-limiting examples include aliphatic diols, such as 2-ethyl-2-methyl-1,3-propanediol, 3,3-dimethyl-1,2-butanediol, 2,2-diethyl-1,3-propanediol, 2-methyl-2-propyl-1,3-propanediol, 2,4-dimethyl-2,4-pentanediol, 2,5-dimethyl-2,5-hexanediol, 5-hexene-1,2-diol and 2-ethyl-1,3-hexanediol, and a mixture thereof.

[0126] In some instances, the cosmetic compositions of the present disclosure include one or more glycols and / or one or more alcohols, for example, one or more water-soluble solvents selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, ethanol, isopropanol, tert-butyl alcohol, and mixtures thereof.

[0127] The total amount of the one or more water-soluble solvents will vary. However, in various embodiments, the total amount of the one or more water-soluble solvents is from about 0.1 to about 20% by weight, based on the total weight of the cosmetic composition. In additional embodiments, the total amount of the one or more water-soluble solvents is about 0.1 to about 20 wt. %, about 0.1 to about 15 wt. %, about 0.1 to about 10 wt. %, about 0.1 to about 5 wt. %, about 0.1 wt. % to about 1 wt. %, about 2 to about 20 wt. %, about 2 to about 15 wt. %, about 2 to about 10 wt. %, about 2 to about 5 wt. %, about 5 to about 20 wt. %, about 5 to about 15 wt. %, or about 5 to about 10 wt. %, based on the total weight of the cosmetic composition. (k) Silicones

[0128] In one embodiment, the composition includes one or more silicones. However, silicones are not necessarily present. Therefore, in some embodiments, they may be excluded from the cosmetic compositions. In other embodiments, it is preferable to include one or more silicones. Non-limiting examples of silicones include dimethicone, dimethiconol, cyclomethicone, polysilicone-11, phenyl trimethicone, trimethylsi- lylamodimethicone and stearoxytrimethylsilane. In some instances, the one or more silicones are non-volatile silicone oils. In some embodiments, the silicone is polydimethylsiloxanes (PDMS), wherein the polydimethylsiloxanes comprise alkyl or alkoxy groups that are pendant and / or at the end of the silicone chain, which groups each contain from 2 to 24 carbon atoms, or phenyl silicones, such as phenyl trimethicones, phenyl dimethicones, phenyl(trimethylsiloxy)diphenylsiloxanes, diphenyl di-methicones, diphenyl(methyldiphenyl)trisiloxanes or (2-phenylethyl)trimethylsiloxysilicates. Other examples of silicone that may be mentioned include linear or cyclic volatile silicones, such as those having a viscosity of 8 centistokes (8x106 m2 / s) and / or containing 2 to 7 silicon atoms.These silicones optionally include alkyl or alkoxy groups containing from 1 to 10 carbon atoms. Non-limiting examples of volatile silicone oils include octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane and dodecamethylpentasiloxane, or mixtures thereof.

[0129] In a preferred embodiment, the cosmetic compositions include one or more silicones selected from dimethicone, dimethiconol, cyclomethicone, polysilicone-11, phenyl trimethicone and amodimethicone, preferably dimethicone.

[0130] In some cases, the cosmetic compositions include one or more amino-functional silicones. Non-limiting examples include amodimethicone, bis-hydroxy / methoxy amodimethicones, bis-cetearyl amodimethicone, amodimethicone, bis(C13-15 alkoxy) PG amodimethicones, aminopropyl phenyl trimethicones, aminopropyl dimethicones, bis-amino PEG / PPG-41 / 3 aminoethyl PG-propyl dimethicones, caprylyl methicones, and a mixture thereof. Amodimethicone is a particularly useful amino-functional silicone.

[0131] The total amount of silicones in the cosmetic composition, if any, will vary. However, in various embodiments, the amount of silicones in the cosmetic composition is from about 0.01 to about 15% by weight, from about 0.01 to about 10% by weight, from about 0.01 to about 5% by weight, from about 0.01 to about 3% by weight, from about 0.01 to about 2% by weight, from about 0.1 to about 15% by weight, from about 0.1 to about 10% by weight, from about 0.1 to about 5% by weight, from about 0.1 to about 3% by weight, from about 0.1 to about 2% by weight, based on the total weight of the cosmetic composition. (1) Miscellaneous ingredients

[0132] The cosmetic compositions of the present disclosure may optionally include one or more miscellaneous ingredients. Miscellaneous ingredients are ingredients that are compatible with the cosmetic compositions and do not interfere with or materially affect the basic and novel properties of the cosmetic compositions. Miscellaneous ingredients commonly used in cosmetic products are known in the art. Non-limiting examples include miscellaneous emulsifiers / surfactants other than those in (c), (d) and (e), preservatives, fragrances, pH adjusting agents, salts, buffers, antioxidants, flavonoids, vitamins, botanical extracts, UV filtering agents, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlescent agents, fillers, colorants, matting agents, additional skin actives, depigmenting agents, anti-wrinkle agents, etc.In a preferred embodiment, the cosmetic compositions of the present disclosure include one or more skin active agents, in particular, a madecassoside. Non-limiting examples of various miscellaneous ingredients that may optionally be included in (or excluded from) the cosmetic compositions are provided below.

[0133] Various emulsifiers / surfactants

[0134] Miscellaneous emulsifiers / surfactants may optionally be included in the cosmetic compositions. Miscellaneous emulsifiers / surfactants are those that are not: (c) a nonionic emulsifier selected from glyceryl esters having an HLB of about 3 to about 8; (d) nonionic emulsifiers having an HLB of about 16 to about 18; and (e) nonionic emulsifiers having an HLB of about 9 to about 15. Miscellaneous emulsifiers / surfactants may be nonionic, anionic, cationic and / or amphoteric / zwitterionic.

[0135] Antioxidants

[0136] Examples of antioxidants include tocopherols (e.g., da-tocopherol, d-[3-tocopherol, dy-tocopherol, d-delta-tocopherol), tocotrienols (e.g., da-tocotrienol, d-[3-tocotrienol, dy-tocotrienol, d-delta-tocotrienol), and vitamin E (a-tocopheryl acetate). These compounds may be isolated from natural sources, prepared by synthetic means, or mixtures thereof. Tocotrienol-enriched vitamin E preparations may be obtained by fractionating vitamin E preparations to remove a portion of tocopherols and recover a more highly concentrated tocotrienol preparation. Useful tocotrienols are natural products isolated, for example, from wheat germ oil, seeds, or palm oil using high-performance liquid chromatography, or isolated by alcohol extraction and / or molecular distillation from barley, spent grain, or oats.As used herein, the term "tocotrienols" includes tocotrienol-rich fractions obtained from these natural products as well as . pure compounds. Increased glutathione peroxidase activity protects the skin from oxidative stress.

[0137] Vitamin C and its derivatives may be used, including ascorbic acid, sodium ascorbate, and the fat-soluble esters tetrahexyldecyl ascorbate and ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl glucoside, glucosamine ascorbate, ascorbyl acetate, etc. In addition, plant extracts containing a high amount of vitamin C such as camu berry (Myrciaria dubia), acerola, emblica officinalis, and rosehip and citrus fruit bioflavonoids may be used, including water-soluble bioflavonoids such as hesperidin methyl chalcone.

[0138] Sesame (Sesamum indicum) or sesame lignan can also be added. Sesame and its lignans (the fibrous compounds associated with sesame) act as antioxidants. Sesame seed lignans significantly increase vitamin E activity.

[0139] In addition, carotenoids, particularly of the xanthophyll type, are also useful antioxidants that can be used. Xanthophyll-type carotenoids include molecules such as lutein, canthaxanthin, cryptoxanthin, zeaxanthin, and astaxanthin. Xanthophylls protect compounds such as vitamin A, vitamin E, and other carotenoids.

[0140] Flavonoids can also function as antioxidants. In some cases, the flavonoid is a flavanone (2,3-dihydro-2-phenylchromen-4-one derivative). Flavones include: butin, eriodictyol, hesperetin, hesperidin, homoeriodictyol, isosakuranetin, naringenin, naringin, pinocembrin, poncirin, sakuranetin, sakuranin, and sterubin. The flavonoid may be a flavanonol (3-hydroxy-2,3-dihydro-2-phenylchromen-4-one derivative). Flavanols include: taxifolin, aromadrin, chrysandroside A, chrysandroside B, xeractinol, astilbin, and fustin. The flavonoid can be a flavone (derived from 2-phenylchromen-4-one). Flavones include: apigenin, luteolin, tangeritin, chrysin, baicalein, scutellarein, wogonin, synthetic flavones: diosmin and flavoxate. The flavonoid can be a flavonol (derived from 3-hydroxy-2-phenylchromen-4-one).Flavonols include: 3-hydroxyflavone, azaleatin, fisetin, galangin, gos-sypetin, kaempferide, kaempferol, isorhamnetin, morin, myricetin, natsudaidaine, pachypodol, quercetin, rhamnazine, rhamnetin, azalein, hyperoside, isoquercitin, kaempferitrin, myricitrin, quercitrin, robinin, rutin, spiraeoside, xanthorhamnin, amurensin, icariin, and troxerutin. The flavonoid may be a flavan-3-ol (2-phenyl-3,4-dihydro-2H-chromen-3-ol derivatives). Flavan-3-ols include: catechin, . epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, repiafzelechin, fisetinidol, guibourtinidol, mesquitol, and robinetinidol. The flavonoid may be a flavan-4-ol (2-phenylchroman-4-ol derivative). Flavan-4-ols include: apiforol and luteoforol. The flavonoid may be an isoflavone (3-phenylchromen-4-one derivative). Isoflavones include: genistein, daidzein, biochanin A, formononetin, and the equol metabolite of daidzein.

[0141] The antioxidant may be an anthocyanidin (derived from the 2-phenylchromenylium cation). Anthocyanidins include: aurantinidin, cyanidin, delphinidin, europinidin, luteolinidin, pelargonidin, malvidin, peonidin, petunidin, rosinidin, and xanthone.

[0142] The antioxidant may be a dihydrochalcone (1,3-diphenyl-l-propanone derivative). Dihydrochalcones include: phloretin, dihydrochalcone phloretin phloridzin, aspalathin, naringin dihydrochalcone, neohesperidin dihydrochalcone and nothofagin. Without limiting the mode of action of the invention, dihydrochalcones may exert an antioxidant effect by reducing reactive free radicals, such as reactive oxygen and reactive nitrogen species.

[0143] The antioxidant may be an anthocyanin. Anthocyanins and their derivatives are antioxidants. Anthocyanins encompass a class of flavonoid compounds that are naturally occurring, water-soluble compounds responsible for the red, purple, and blue colors of many fruits, vegetables, grains, and flowers. In addition, anthocyanins are collagenase inhibitors. Inhibition of collagenase facilitates the prevention and reduction of wrinkles, increased skin elasticity, etc., which are caused by a reduction in skin collagen. Anthocyanins may be obtained from any part of various plant sources, such as the fruit, flower, stem, blossoms, root, bark, or seeds. Those skilled in the art will understand that certain parts of the plant may contain higher natural levels of anthocyanins, and therefore, these parts are used to obtain the desired anthocyanins.In some cases, antioxidants may include one or more betacyanins. Betacyanins, like anthocyanins, can be obtained from natural sources and are antioxidants.

[0144] The antioxidant may be a phenylpropanoid (cinnamic acid derivatives). Phenylpropanoids include: cinnamic acid, caffeic acid, ferulic acid, trans-ferulic acid (including its antioxidant pharmacore 2,6-dihydroxyacetophenome), 5-hydroxyferulic acid, sinapic acid, coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, eugenol, chavicol, safrole, P-coumaric acid and sinapinic acid. Without limiting the mode of action of the invention, phenylpropanoids can neutralize free radicals.

[0145] The antioxidant may be a chalcone (1,3-diphenyl-2-propen-1-one derivative). Chalcones include: butein, okanin, carthamine, marein, sophoradin, xanthohumol, flavokavain A, flavokavain B, flavokavain C, and synthetic safalcone.

[0146] The antioxidant may be a curcuminoid. Curcuminoids include: curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, tetrahydrocurcumin, and tetrahydrocurcuminoids. Curcumin and tetrahydrocurcuminoids may be derived from the rhizomes of Curcuma longa. Tetrahydrocurcumin, a metabolite of curcumin, has been shown to be a more potent and stable antioxidant compared to curcumin.

[0147] The antioxidant may be a tannin. Tannins include: tannin, terflavin B, glu-cogallin, D-gallic acid, and quercitannic acid.

[0148] The antioxidant may be a stilbenoid. Stilbenoids include: Resveratrol, pterostilbene, and piceatannol. Resveratrol may include, but is not limited to, 3,5,4'-trihydroxystilbene, 3,4,3',5'-tetrahydroxystilbene (piceatannol), 2,3',4,5'-tetrahydroxystilbene (oxyresveratrol), 4,4'-dihydroxystilbene, and alpha and beta glucoside, galactoside, and mannoside derivatives thereof.

[0149] The antioxidant may be a coumarin (2H-chromen-2-one derivatives). Coumarins include: 4-hydroxycoumarin, umbelliferone, esculetin, herniarin, auraptene, and dicoumarol.

[0150] The antioxidant may be a carotenoid. Carotenoids include: beta-carotene, alpha-carotene, gamma-carotene, beta-cryptoxanthin, lycopene, lutein, and idebenone. Sesame (Sesamum indicum) or sesame lignan may also be added. Sesame and its lignans (the fibrous compounds associated with sesame) act as antioxidants. Sesame seed lignans significantly increase the activity of vitamin E.

[0151] The antioxidant may be: a xanthone, butylated hydroxytoluene, 2,6-di-tert-butylphenol, 2,4-dimethyl-6-tert-butylphenol, gallic acid, eugenol, uric acid, alpha-lipoic acid, ellagic acid, chicoric acid, chlorogenic acid, rosmarinic acid, salicylic acid, acetylcysteine, S-allyl cysteine, barbigerone, chebulagic acid, edaravone, ethoxyquin, glutathione, hydroxytyrosol, idebenone, melatonin, N-acetylserotonin, nordihydroguaiaretic acid, oleocanthal, oleuropein, paradol, piceatannol, probucol, propyl gallate, protocatechuic acid, pyritinol, rutin, secoisolariciresinol diglucoside, sesamin, sesamol, silibinin, silymarin, theaflavin, theaflavin digallate, thymoquinone, trolox, tyrosol,polyunsaturated fatty acids and sulfur-based antioxidants such as methionine or, lipoic acid.

[0152] Active agents for the skin

[0153] Non-limiting examples of skin active agents include madecassoside, sodium hyaluronate, retinoic acid, benzoyl peroxide, sulfur, vitamin B6 (or pyridoxine) chloride, selenium, samphire—mixtures of cinnamon, tea and octanoylglycine extracts such as—Sepicontrol A5 TEA from Seppic—the mixture of cinnamon, sarcosine and octanoylglycine marketed in particular by Seppic under the brand name Sepicontrol A5—zinc salts such as zinc gluconate, zinc pyrrolidonecarboxylate (or zinc pidolate), zinc lactate, zinc aspartate, zinc carboxylate, zinc salicylate, zinc cysteate—derivatives in particular of copper and copper pidolate such as Cuivridone Solabia—extracts plants of Arnica montana, Cinchona succirubra, Eugenia ca-ryophyllata, Humulus lupulus, Hypericum perforatum, Mentha pipenta Rosmarinus of-ficinalis, Salvia officinalis and Thymus vulgaris,all marketed for example by Maruzen—extracts of meadowsweet (Spiraea ulmaria), such as that sold under the name Sebonormine by Silab—extracts of the algae Laminaria saccharina, such as that sold under the name Phlorogine by Biotechmarine—extracts of mixtures of Burnet root (Sanguisorba officinalis / Poterium officinale), ginger rhizomes (Zingiber officinalis) and cinnamon bark (Cinnamomum cassia), such as that sold under the name Sebustop by Solabia—extracts of flax seeds such as that sold under the name Linumine by Lucas Meyer—extracts of phellodendron such as those sold under the name Phellodendron extract BG by Maruzen or Oubaku liquid B by Ichimaru Pharcos—mixtures of argan oil extract, Serenoa serrulata (saw palm) and sesame seeds such as that sold under the name Regu SEB by Pentapharm—blends of extracts of willowherb, Terminalia chebula, nasturtium and bioavailable zinc (microalgae),such as that sold under the name Seborilys Green Tech; Pygeum afrianum extracts such as that sold under the name Pygeum afrianum sterolic lipid extract by Euromed; Serenoa serrulata extracts such as those sold under the name Viapure Sabal by Actives International, and those sold by the company Euromed; mixtures of plantain extracts, Berberis aquifolium and sodium salicylate such as that sold under the name Seboclear Rahn; clove extract such as that sold under the name Clove extract powder by Maruzen; argan oil such as that sold under the name Li-pofructyl Laboratories Serobiologiques; —lactic protein filtrates, such as that sold under the name Normaseb by Sederma—laminaria algae extracts, such as that sold under the name Laminarghane by Biotechmarine—oligosaccharides from Laminaria digitata algae,such as that sold under the name Phycosaccharide AC by the company Codif—sugar cane extracts such as that sold under the name Po- , licosanol by the company Sabinsa, sulfonated shale oil, such as that sold under the name Ichtyol Pale by Ichthyol—extracts of meadowsweet (Spiraea ulmaria) such as that sold under the name Cytobiol Ulmaire by the company Libiol—sebacic acid, in particular sold in the form of a sodium polyacrylate gel under the name Sebosoft by Sederma—glucommanans extracted from konjac tuber and modified with alkylsulfonate chains such as that sold under the name Biopol Beta by Arch Chemical—extracts of Sophora angustifolia, such as those sold under the name Sophora powder or Sophora extract by Bioland—extracts of cinchona succirubra bark such as that sold under the name Red Bark HS by Alban Muller—extracts of Quillaja saponaria such as that sold under the name Panama wood HS by Alban Muller—glycine grafted onto an undecylenic chain,such as that sold under the name Lipacide UG OR by SEPPIC—the mixture of oleanolic acid and nordihydroguaiaretic acid, such as that sold in gel form under the name AC.Net by Sederma; —phthalimidoperoxyhexanoic acid—tri(C12-C13) citrate sold under the name COSMACOL.RTM ECI by Sasol; trialkyl(C14-C15) citrate sold under the name COSMACOL.RTM. ECL by Sasol—10-hydroxydecanoic acid, including mixtures of hydroxydecanoic acid, sebacic acid and 1,10-decandiol such as that sold under the name Acnacidol BG by Vincience and mixtures thereof. ,

[0154] Depigmentation agents

[0155] Non-limiting examples of depigmenting agents include alpha and beta arbutin, ferulic acid, lucinol and derivatives thereof, kojic acid, resorcinol and derivatives thereof, tranexamic acid and derivatives thereof, gentisic acid, homogentisic acid, methyl gentisate or homogentisate, dioic acid, D-panthenate calcium sulfonate, lipoic acid, ellagic acid, vitamin B3, linoleic acid and derivatives thereof, certain plant-derived compounds such as chamomile, bearberry, asphodelaceae (vera, ferox, bardensis), blackberry, skullcap, kiwi (Actinidia chinensis) marketed by Gattefosse, a root extract of Paeonia suffruticosa, such as that sold by Ichimaru Pharcos under the name Liquid Botanpi Be, a brown sugar extract (Saccharum officinarum) such as a molasses extract marketed by Taiyo Kagaku under the name Liquid Molasses, but this list is not exhaustive.Particular depigmenting agents include alpha and beta arbutin, ferulic acid, kojic acid, resorcinol and its derivatives, D-panthenol calcium sulfonate, lipoic acid, ellagic acid, vitamin B3, a kiwi fruit (Actinidia chinensis) marketed by Gattefosse, a root extract of Paeonia suffruticosa, such as that sold by the company Ichimaru Pharcos under the name Botanpi Liquid B.

[0156] Anti-wrinkle agent

[0157] The term "anti-wrinkle agent" refers to a natural or synthetic compound producing a biological effect, such as the synthesis and / or increased activity of certain enzymes, when brought into contact with a wrinkled area of ​​skin, this has the effect of reducing the appearance of wrinkles and / or fine lines. Non-limiting examples of anti-wrinkle agents include: desquamating agents, anti-glycation agents, NO-synthase inhibitors, agents stimulating the synthesis of dermal or epidermal macromolecules and / or the prevention of their degradation, agents for stimulating the proliferation of fibroblasts and / or keratinocytes, or for stimulating agents reducing the differentiation of keratinocytes;muscle relaxants and / or dermo-de-contracting agents, free radical scavengers and mixtures thereof. Examples of such compounds are: adenosine and its derivatives and retinoids other than retinol (as indicated above, such as retinyl palmitate), ascorbic acid and its derivatives such as magnesium ascorbyl phosphate and ascorbyl glucoside; nicotinic acid and its precursors such as nicotinamide; ubiquinone; glutathione and precursors thereof such as L-2-oxothiazolidine-4-carboxylic acid, C-glycoside compounds and their derivatives as described in particular in EP-1345919, in particular C-beta-D-xylopyranoside-2-hydroxy-propane as described in particular in EP-1345919, plant extracts including sea fennel and olive leaf extracts, as well as a plant and hydrolysates thereof such as rice protein hydrolysates or soy proteins;algal extracts and in particular kelp, bacterial extracts, sapogenins such as diosgenin and extracts of Dioscorea plants, in particular hairy yam, including: α-hydroxy acids, β-hydroxy acids, such as salicylic acid and n-octanoyl-5-salicylic oligopeptides and pseudodipeptides and acyl derivatives thereof, in particular acid; {2-[acetyl-(3-trifluoromethyl-phenyl)-amino]-3-methyl]-acetic acid and lipopeptides marketed by the company under the brand names SEDERMA Matrixyl 500 and Matrixyl 3000; lycopene, manganese salts and magnesium salts, in particular gluconates, and mixtures thereof. In at least one instance, the skin tightening composition includes adenosine derivatives, such as non-phosphate derivatives of adenosine, in particular such as 2'-deoxyadenosine, 2',3'-adenosine isopropopylidene; toyocamycin, 1-methyladenosine, N-6-methyladenosine; adenosine N-oxide, 6-methylmercaptopurine riboside and 6-chloropurine riboside.Other derivatives include adenosine receptor agonists such as phenylisopropyl adenosine ("PIA"), 1-methylisoguanosine, N6-cyclohexyladenosine (CHA), N6-cyclopentyladenosine (CPA), 2-chloro-N6-cyclopentyladenosine, 2-chloroadenosine, N6-phenyladenosine, 2-phenylaminoadenosine, MECA, N6-phenethyladenosine, . 2-p-(2-carboxy-ethyl)phenethyl-amino-5'-N-ethylcarboxamido adenosine (CGS-21680), N-ethylcarboxamido-adenosine (NECA), 5'(N-cyclopropyl)-carboxamidoadenosine, DPMA (PD 129,944) and metrifudil.

[0158] Various ingredients may rationally be included in the cosmetic composition and if so, the amount will vary. However, in various embodiments the total amount of the one or more various ingredients is from about 0.01 to about 10% by weight, based on the total weight of the cosmetic composition. In additional embodiments, the total amount of the one or more miscellaneous ingredients is about 0.01 to about 8% by weight, about 0.01 to about 5% by weight, about 0.01 to about 3% by weight, about 0.1 to about 10% by weight, about 0.1 to about 8% by weight, about 0.1 to about 5% by weight, about 0.1 to about 3% by weight, about 1 to about 10% by weight, about 1 to about 8% by weight, about 1 to about 5% by weight, or about 1 to about 3% by weight, based on the total weight of the cosmetic composition.

[0159] As already noted, skin active agents may be included as one or more of the various ingredients. With respect to the total amount of skin active agents in the cosmetic compositions, if any, the total amount of skin active agents may be from greater than zero to about 9% by weight, from greater than zero to about 8% by weight, from greater than zero to about 7% by weight, from greater than zero to about 6% by weight, from greater than zero to about 5% by weight, from greater than zero to about 4% by weight, from greater than zero to about 3% by weight, from greater than zero to about 2% by weight;from about 10 ppm to about 10 wt% (100,000 ppm), from about 10 ppm to about 5 wt% (50,000 ppm), from about 10 ppm to about 2.5 wt% (25,000 ppm), from about 10 ppm to about 1 wt% (10,000 ppm), from about 10 ppm to about 0.5 wt% (5,000 ppm), from about 10 ppm to about 0.3 wt% (3,000 ppm), from about 10 ppm to about 0.2 wt% (2,000 ppm), from about 10 ppm to about 0.1 wt% (1,000 ppm), from about 10 ppm to 500 ppm; from about 0.1 to about 10% by weight, from about 0.1 to about 5% by weight, from about 0.1 to about 2.5% by weight, from about 0.1 to about 1% by weight, from about 0.1 to about 0.5% by weight; from about 1 to about 10% by weight, from about 1 to about 8% by weight, from about 1 to about 6% by weight, from about 1 to about 5% by weight, from about 1 to about 4% by weight, from about 1 to about 3% by weight;from about 2 to about 10% by weight, from about 2 to about 8% by weight, from about 2 to about 6% by weight, from about 2 to about 5% by weight, from about 2 to about 4% by weight; from about 3 to about 10% by weight, from about 3 to about 8% by weight, from about 3 to about 6% by weight, from about 3 to about 5% by weight; from about 4 to about 10% by weight, from about 4 to about 8% by weight, or from about 4 to about 6% by weight, based on the total weight of the cosmetic composition. ; PH

[0160] In one embodiment, the cosmetic compositions have a pH of about 4 to about 8. In additional embodiments, the pH of the cosmetic compositions is 4.5 to about 8, about 5 to about 8, about 5.5 to about 8, about 4 to about 7.5, about 4 to about 7, about 4.5 to about 8, about 4.5 to about 7.5, about 4.5 to about 7, about 5 to about 8, about 5 to about 7.5, or about 5 to about 7. In various embodiments, the pH of the cosmetic compositions does not change by more than ± 1 pH unit, ± 0.5 pH unit, ± 0.3 pH unit, or ± 0.2 pH unit, for at least 2 weeks, 4 weeks, and / or 8 weeks in a storage at 4°C, 25°C, 37°C and / or 45°C. Stability

[0161] The cosmetic compositions of the present disclosure are stable. For example, the cosmetic compositions do not visually phase separate or form visible particles for at least 2 weeks, 4 weeks, and / or 8 weeks when stored at 4°C, 25°C, 37°C, and / or 45°C.

[0162] In various embodiments, the cosmetic compositions do not visually phase separate or form visible particles during at least 10 freeze-thaw testing cycles, wherein the freeze-thaw testing comprises placing the cosmetic composition in a stability chamber and subjecting it to a temperature fluctuation at 12-hour intervals, for a first 12-hour interval at -20°C followed by a second 12-hour interval at 25°C.

[0163] In various embodiments, the viscosity of the cosmetic compositions does not change by more than 20%, 15%, 10% or 5%, for at least 2 weeks, 4 weeks and / or 8 weeks in storage at 4°C, 25°C, 37°C and / or 45°C. Viscosity

[0164] In general, the cosmetic compositions of the present case have a viscosity of about 5,000 to about 200,000 Pa.s at 25°C, and a shear rate of 1 s 1 at 25°C. However, the cosmetic compositions may have a viscosity of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, about 10,000 to about 150,000 Pa.s, about 10,000 to about 120,000 Pa.s, about 15,000 to about 200,000 Pa.s, from about 15,000 to about 180,000 Pa.s, from about 15,000 to about 150,000 Pa.s, from about 15,000 to about 120,000 Pa.s, from about 20,000 to about 200,000 Pa.s, from about 20,000 to about 180,000 Pa.s, from about 20,000 to about 150,000 Pa.s, or about 20,000 to about 120,000 Pa.s at 25 °C, and a shear rate of 1 s 1 at 25 °C.

[0165] Viscosity measurements may be made, for example, using a Brookfield viscometer / rheometer using a T-bar spindle at a speed of 5, 10, 15, and / or 20 rpm. An RVDV-II+Pro viscometer with RheocalcT software may be used for automatic instrument control and data acquisition. The test temperature is maintained at 25°C using a Brookfield TC-502P programmable refrigerated bath. From its original container, a sample is transferred to a 120 ml glass carboy and then tested. Processes

[0166] The present disclosure relates to methods of treating skin. The methods include applying a cosmetic composition according to the present disclosure, optionally allowing the cosmetic composition to remain on the skin for a period of time. The cosmetic compositions are typically applied directly to the skin by hand or using a wipe. The skin may optionally be washed or rinsed before application. The method of treating the skin may be performed once daily or may be performed multiple times. For example, the method of treating the skin may be performed once daily, twice daily, once weekly, or twice weekly for an extended period of time, for example, for about 1, 2, 3, 4, 5, or 6 months up to 1 year or longer.In one embodiment, the methods reduce the appearance of fine lines and wrinkles, enhance hyaluronic acid production via stimulation of glycosaminoglycan (GAG) synthesis, thereby softening the stratum corneum to relieve cumulative stress on the epidermis and dermis, etc. When tert-butylcyclohexanol is included in the compositions, the methods further treat skin irritation, soothe the skin, and / or reduce or alleviate stinging, burning, and tightness.

[0167] The present disclosure also relates to methods of stabilizing a cosmetic composition containing high amounts of hydroxypropyl tetrahydropyrantriol, and optionally high amounts of 4-tert-butylcyclohexanol, where applicable. These methods comprise incorporating hydroxypropyl tetrahydropyrantriol, and optionally 4-tert-butylcyclohexanol, into the compositions of the present disclosure. The amounts of hydroxypropyl tetrahydropyrantriol and 4-tert-butylcyclohexanol that may be incorporated are the amounts indicated throughout the present disclosure. Kits

[0168] The cosmetic compositions of the present disclosure may be provided in a kit, for example, a kit comprising an individually contained cosmetic composition according to the present disclosure and one or more cosmetic compositions additional compositions contained separately. In one embodiment, the one or more separately contained compositions may be an additional composition according to the present disclosure or may be a different composition. The cosmetic compositions may be separately contained in different cartridges, which are included in a dispensing apparatus / device. In other words, the kit may be a dispensing apparatus / device comprising a plurality of cartridges in which the compositions are contained. The kit (or apparatus / device) may optionally dispense the cosmetic composition of the present disclosure and separately dispense the one or more separately contained compositions. In various embodiments, the compositions may be dispensed individually or simultaneously, and may optionally be mixed (or not mixed) with each other before being dispensed.In one embodiment, the various compositions are not mixed with each other prior to being dispensed. Useful dispensing systems, cartridges, and apparatus / devices are disclosed in U.S. Patent Nos. 9,968,177 and 9,808,071; U.S. Patent Application Publication Nos. 2021 / 0236390, 2021 / 0235849, and 2021 / 0236863; and U.S. Series No. 17 / 162,555, all of which are incorporated herein by reference in their entirety. Embodiments.

[0169] In certain embodiments, the cosmetic composition comprises or consists of:

[0170] (a) about 10 to about 40% by weight, preferably about 10 to about 20% by weight, more preferably about 12 to about 18% by weight of hydroxypropyl tetrahydropyrantriol;

[0171] (b) about 50 to about 85% by weight, preferably about 55 to about 80% by weight, more preferably about 55 to about 75% by weight of water;

[0172] (c) about 0.1 to about 5 wt%, preferably about 0.1 to about 4, of more preferably about 0.2 to about 3% by weight of one or more nonionic emulsifiers selected from glyceryl esters having an HLB of about 3 to about 8, for example, glyceryl esters selected from glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl lanolate, glyceryl laurate, glyceryl myristate, glyceryl palmitate lactate, glyceryl stearate, glyceryl distearate, glyceryl laurate, and a mixture thereof, preferably one or more glyceryl esters selected from glyceryl stearate, glyceryl ricinoleate, and a mixture thereof;

[0173] (d) about 0.1 to about 5 wt%, preferably about 0.1 to about 4, of more preferably about 0.2 to about 3% by weight of one or more nonionic emulsifiers having an HLB of about 16 to about 18, preferably one or more ethoxylated emulsifiers selected from ethoxylated fatty acids, esters ethoxylated sorbitan fats, and a mixture thereof, preferably one or more ethoxylated fatty acids;

[0174] (e) about 0.1 to about 5% by weight, preferably about 0.5 to about 5% by weight, more preferably about 0.5 to about 4% by weight of one or more nonionic emulsifiers having an HLB of about 9 to about 15, for example, selected from alkylpolyglucosides (cetearyl glucoside), polyglycerol-based emulsifiers (polyglyceryl-3 methylglucose distearate), sorbitan fatty esters (polysorbate 60), sugar esters or ethers, sugar-based esters or ethers, polyol fatty esters or ethers, glyceryl fatty esters or ethers, ethoxylates thereof, or mixtures thereof, preferably selected from sugar esters or ethers and sugar-based esters or ethers;

[0175] (f) about 1 to about 10% by weight, preferably about 1 to about 8% by weight, more preferably about 1 to about 6% by weight of one or more fatty alcohols, preferably selected from fatty alcohols having from 8 to 24 carbon atoms, preferably selected from cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, lignoceryl alcohol, and mixtures thereof;

[0176] (g) about 5 to about 20% by weight, preferably about 5 to about 15% by weight, more preferably about 6 to about 12% by weight of one or more fatty compounds, for example, selected from fatty esters (e.g., isononyl iso-nonanoate), polyolefins (petrolatum), waxes, squalane, squalene, hydrogenated polyisobutene, hydrogenated polydecene, polybutene, mineral oil, pentahydrosqualene, plant and / or vegetable oil (e.g., soybean oil), hydrocarbon-based oils (e.g., isohexadecane), and a mixture thereof;

[0177] (h) one or more thickening polymers, preferably one or more co taurate polymers, in particular, one or more taurate copolymers selected from an acrylamide / sodium acryloyl dimethyl taurate copolymer, a hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, an ammonium acryloyldimethyl taurate / VP copolymer, a sodium acrylate / sodium acryloyl dimethyl taurate copolymer, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and a mixture thereof, wherein the amount of the one or more thickening polymers may optionally be from about 1 to about 8% by weight, preferably from about 1 to about 5% by weight, more preferably from about 1 to about 3% by weight;

[0178] (i) optionally, 4-tert-butylcyclohexanol, wherein, where appropriate, it is preferably in an amount of about 0.1 to about 5% by weight, preferably from about 0.5 to about 4% by weight, more preferably from 0.5 to about 3% by weight;

[0179] (j) optionally, one or more water-soluble solvents, for example, one or several water-soluble solvents selected from glycerin, alcohols (e.g., C1-30, C1-15, C1-10 or C1-4 alcohols), organic solvents, polyols (polyhydric alcohols, e.g., ethanol, isopropanol, t-butyl alcohol, etc.), glycols (e.g., propylene glycol, butylene glycol, pentylene glycol, etc.), and a mixture thereof, preferably one or more monoalcohols selected from ethanol, isopropanol and t-butyl alcohol, and one or more glycols selected from propylene glycol, butylene glycol and pentylene glycol, wherein, where appropriate, the one or more water-soluble solvents comprise from about 0.1 to about 20% by weight, preferably from about 0.1 to about 15% by weight, more preferably from about 1 to about 15% by weight of the cosmetic composition;

[0180] (k) optionally, one or more silicones, for example, dimethicone, dimethiconol, cyclomethicone, polysilicone-11, phenyl trimethicone and amodimethicone, preferably dimethicone, wherein, if present, the one or more silicones may be in an amount of about 0.01 to about 10% by weight, about 0.1 to about 5% by weight, more preferably about 0.1 to about 3% by weight;

[0181] (1) optionally, one or more miscellaneous ingredients, for example, one or more miscellaneous ingredients selected from various emulsifiers / surfactants, preservatives, fragrances, pH adjusting agents, salts, buffers, antioxidants, flavonoids, vitamins, botanical extracts, UV filtering agents, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlescent agents, fillers, colorants, matting agents, additional skin active agents, depigmenting agents, anti-wrinkle agents, wherein, where appropriate, the one or more miscellaneous ingredients comprise from about 0.01 to about 0.1 to about 10% by weight, preferably from about 0.1 to about 8% by weight, more preferably from about 1 to about 8% by weight of the cosmetic composition

[0182] wherein the composition is an oil-in-water emulsion, preferably a gel emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

[0183] The composition preferably has a pH of about 4 to about 8, preferably about 5 to about 8, more preferably about 4.5 to about 7.5.

[0184] The cosmetic compositions of the present disclosure are stable. For example, in one embodiment the cosmetic compositions do not separate vi only in phases or form visible particles for at least 2 weeks, 4 weeks and / or 8 weeks in storage at 4°C, 25°C, 37°C and / or 45°C.

[0185] In another embodiment, the cosmetic compositions do not visually phase separate or form visible particles during at least 10 freeze-thaw test cycles, wherein the freeze-thaw tests comprise placing the cosmetic composition in a stability chamber and subjecting it to a temperature fluctuation at 12-hour intervals, for a first 12-hour interval at -20°C followed by a second 12-hour interval at 25°C.

[0186] In one embodiment, the viscosity of the cosmetic compositions does not change by more than 20%, 15%, 10% or 5%, for at least 2 weeks, 4 weeks and / or 8 weeks in storage at 4°C, 25°C, 37°C and / or 45°C.

[0187] In some embodiments, the cosmetic composition preferably has a viscosity of about 5,000 to about 200,000 Pa.s at 25°C, and a shear rate of 1 s 1 at 25°C. However, the cosmetic compositions may have a viscosity of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, from about 10,000 to about 150,000 Pa.s, from about 10,000 to about 120,000 Pa.s, from about 15,000 to about 200,000 Pa.s, from about 15,000 to about 180,000 Pa.s, from about 15,000 to about 150,000 Pa.s, from about 15,000 to about 120,000 Pa.s, from about 20,000 to about 200,000 Pa.s, from about 20,000 to about 180,000 Pa.s, from about 20,000 to about 150,000 Pa.s, or from about 20,000 to about 120,000 Pa.s at 25 °C, and a shear rate of 1 s 1 at 25 °C.

[0188] In certain embodiments, the cosmetic composition comprises or consists of:

[0189] (a) about 10 to about 40% by weight, preferably about 10 to about 20% by weight, more preferably about 12 to about 18% by weight of hydroxypropyl tetrahydropyrantriol;

[0190] (b) about 50 to about 85% by weight, preferably about 55 to about 80% by weight, more preferably about 55 to about 75% by weight of water;

[0191] (c) about 0.1 to about 5 wt%, preferably about 0.1 to about 4, of more preferably about 0.2 to about 3% by weight of one or more nonionic emulsifiers selected from glyceryl esters having an HLB of about 3 to about 8, in particular selected from glyceryl stearate, glyceryl ri-cinoleate, and a mixture thereof, preferably glyceryl stearate;

[0192] (d) about 0.1 to about 5 wt%, preferably about 0.1 to about 4, of more preferably about 0.2 to about 3% by weight of one or more nonionic emulsifiers having an HLB of about 16 to about 18 selected from ethoxylated fatty acids, ethoxylated sorbitan fatty esters, and a mixture thereof, preferably one or more ethoxylated fatty acids;

[0193] (e) about 0.1 to about 5% by weight, preferably about 0.5 to about 5% by weight, more preferably about 0.5 to about 4% by weight of one or more nonionic emulsifiers having an HLB of about 9 to about 15, for example, selected from alkylpolyglucosides (cetearyl glucoside), polyglycerol-based emulsifiers (polyglyceryl-3 methylglucose distearate), sorbitan fatty esters (polysorbate 60), sugar esters or ethers, sugar-based esters or ethers, polyol fatty esters or ethers, glyceryl fatty esters or ethers, ethoxylates thereof, or mixtures thereof, preferably selected from sugar esters or ethers and sugar-based esters or ethers;

[0194] (f) about 1 to about 10% by weight, preferably about 1 to about 8% by weight, more preferably about 1 to about 6% by weight of one or more fatty alcohols having from 8 to 24 carbon atoms, preferably selected from cetyl alcohol, cetearyl alcohol, behenyl alcohol, and mixtures thereof;

[0195] (g) about 5 to about 20% by weight, preferably about 5 to about 15% by weight, more preferably about 6 to about 12% by weight of one or more fatty compounds, for example, selected from fatty esters (e.g., isononyl iso-nonanoate), polyolefins (petrolatum), waxes, squalane, squalene, hydrogenated polyisobutene, hydrogenated polydecene, polybutene, mineral oil, pentahydrosqualene, plant and / or vegetable oil (e.g., soybean oil), hydrocarbon-based oils (e.g., isohexadecane), and a mixture thereof;

[0196] (h) from about 1 to about 8% by weight, preferably from about 1 to about 5% by weight, more preferably from about 1 to about 3 wt.% of one or more taurate copolymers, in particular, one or more taurate copolymers selected from acrylamide / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and a mixture thereof, preferably selected from hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, and a mixture of these;

[0197] (i) optionally, 4-tert-butylcyclohexanol, wherein, where appropriate, it is preferably in an amount of about 0.1 to about 5% by weight, preferably about 0.5 to about 4% by weight, more preferably 0.5 to about 3% by weight;

[0198] (j) from about 0.1 to about 20% by weight, preferably from about 0.1 to about 15% by weight, more preferably from about 1 to about 5% by weight of one or more water-soluble solvents selected from one or more monohydric alcohols (e.g., ethanol, isopropanol, and t-butyl alcohol), one or more glycols (e.g., propylene glycol, butylene glycol, and pentylene glycol), and a mixture thereof;

[0199] (k) about 0.01 to about 10 wt%, about 0.1 to about 5 wt%, of more preferably about 0.1 to about 3% by weight of one or more silicones, for example, dimethicone, dimethiconol, cyclomethicone, polysilicone-11, phenyl trimethicone and amodimethicone, preferably dimethicone;

[0200] (1) optionally, one or more miscellaneous ingredients, for example, one or more miscellaneous ingredients selected from various emulsifiers / surfactants, preservatives, fragrances, pH adjusting agents, salts, buffers, antioxidants, flavonoids, vitamins, botanical extracts, UV filtering agents, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlescent agents, fillers, colorants, matting agents, additional skin active agents, depigmenting agents, anti-wrinkle agents, wherein, where appropriate, the one or more miscellaneous ingredients comprise from about 0.01 to about 0.1 to about 10% by weight, preferably from about 0.1 to about 8% by weight, more preferably from about 1 to about 8% by weight of the cosmetic composition

[0201] wherein the composition is an oil-in-water emulsion, preferably a gel emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

[0202] The composition preferably has a pH of about 4 to about 8, preferably about 5 to about 8, more preferably about 4.5 to about 7.5.

[0203] The cosmetic compositions of the present disclosure are stable. For example, in one embodiment the cosmetic compositions do not visually phase separate or form visible particles for at least 2 weeks, 4 weeks and / or 8 weeks when stored at 4°C, 25°C, 37°C and / or 45°C.

[0204] In another embodiment, the cosmetic compositions do not visually phase separate or form visible particles during at least 10 freeze-thaw test cycles, wherein the freeze-thaw tests comprise placing the cosmetic composition in a stability chamber and subjecting it to a temperature fluctuation at 12-hour intervals, for a first 12-hour interval at -20°C followed by a second interval of 12 hours at 25°C.

[0205] In one embodiment, the viscosity of the cosmetic compositions does not change by more than 20%, 15%, 10% or 5%, for at least 2 weeks, 4 weeks and / or 8 weeks in storage at 4°C, 25°C, 37°C and / or 45°C.

[0206] In some embodiments, the cosmetic composition preferably has a viscosity of about 5,000 to about 200,000 Pa.s at 25°C, and a shear rate of 1 s 1 at 25°C. However, the cosmetic compositions may have a viscosity of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, about 10,000 to about 150,000 Pa.s, about 10,000 to about 120,000 Pa.s, about 15,000 to about 200,000 Pa.s, about 15,000 to about 180,000 Pa.s, about 15,000 to about 150,000 Pa.s, about 15,000 to about 120,000 Pa.s, about 20,000 to about 200,000 Pa.s, about 20,000 to about 180 000 Pa.s, from about 20,000 to about 150,000 Pa.s, or from about 20,000 to about 120,000 Pa.s at 25 °C, and a shear rate of 1 s 1 at 25 °C. EXAMPLES

[0207] Since various changes may be made in the methods described above without departing from the scope of the invention, it is intended that the entire contents of the above description and the examples given below are to be interpreted in an illustrative and not limiting sense.

[0208] The following Examples are intended to be non-restrictive and explanatory only. The amounts of ingredients in the compositions / formulas described below are expressed in % by weight, based on the total weight of the composition. Example 1 (Compositions of the invention)

[0209] [Tables 1] ABCD (a) Active ingredient HYDROXYPROPYL TETRAHYDROPY- RANTRIOL 15 15 15 15 (b) Water WATER 63.5 63.9 63.5 63.9 (c) Glyceryl ester GLYCERYL STEARATE (HLB 3.8 ± 1) 0.3 0.3 0.3 0.3 (d) High HLB emulsifier PEG-40 STEARATE (HLB 17.5) 0.4 0.4 0.4 0.4 (e) Intermediate HLB emulsifier POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE (HLB-12) 0.5 0.5 0.5 0.5 CETEARYL GLUCOSIDE (HLB 11 + 1) 0.2 0.2 0.2 0.2 POLYSORBATE 60 (HLB 14.9 + 1) 0.0 4 0.04 0.04 0.04 (f) Fatty alcohol CETYL ALCOHOL 0.3 0.3 0.8 0.8 BEHENYL ALCOHOL 1.0 1.0 1.0 1.0 CETEARYL ALCOHOL 0.8 0.8 0.3 0.3 (g) Fatty compound SQUALANE, ISONONYL ISONONANOATE AND SOYBEAN OIL 9 9 9 9 (h) Thickening polymers HYDROXYETHYL ACRYLATE / SODIUM ACRYLOYLDIMETHYL THYLTAURATE COPOLYMER 0.7 0.7 0.7 0.7 COPOLYMER OF AMMONIUM ACRYLOYLDIMETHYLTAURATE / VP 0.7 0.7 0.7 0.7 POLY C10-30 ALKYL ACRYLATE 0.5 0.5 0.5 0.5 (i) Active ingredient 4-T-BUTYLCYCLOHEXANOL 1.1 1.1 1.1 1.1 (J) Soluble solvent PROPYLENE GLYCOL,PENTYLENE GLYCOL AND T-BUTYL ALCOHOL 4.2 4.2 4.2 4.2 , in water (k) Silicone DIMETHICONE 0.5 0.5 0.5 0.5 ((1) Various emulsifiers SORBITAN ISOSTEARATE (HLB 4.7) 0.0 4 0.04 0.04 0.04 HYDROGENATED LECITHIN 0.3 0.3 Other various emulsifiers / surfactants, salts, preservatives, pH adjusting agents, perfumes, colorants, chelating agents, extracts, fillers, absorbents, additional active ingredients for the skin, etc. <4 <4 <4 <4 Stability Yes Yes Yes Yes Example 2 (Comparative compositions)

[0210] [Tables2] Cl C-2 C-3 (a) Active ingredient HYDROXYPROPYL TETRAHYDROPY- RANTRIOL 15 15 15 (b) Water WATER 69.5 61.5 55.8 (c) Glyceryl ester GLYCERYL STEARATE (HLB = 3.8) 1.6 (d) High HLB STEARETH-100 (HLB = 18.8) 0.4 (e) Emulsifiers with intermediate HLB ARACHIDYL GLUCOSIDE (HLB ~10) ALKYL (EN C12-20) GLUCOSIDE (HLB = 10.3) 0.4 CETEARYL GLUCOSIDE (HLB = 11) 0.1 POLYSORBATE 80 (HLB = 15) 0.2 POLYSORBATE 60 (HLB = 14.9) 0.04 (f) Fatty Alcohols ARACHIDYL ALCOHOL, BEHENYL ALCOHOL, CETEARYL ALCOHOL, CETYL ALCOHOL AND / OR C14-22 ALCOHOLS 3.2 1.1 4.1 (g) Fatty Compounds SQUALANE. SOYBEAN OIL, DTSONONYL ISO-NONANOATE, ISO-HEXADECANE, DICAPRYLYL ETHER AND / OR CAPRYLIC / CAPRIC TRIGLYCERIDE 2 9.5 4 (h) Thickening Polymers ACRYLAMIDE / SODIUM ACRYLOYLDIMETHYL AURATE COPOLYMER 1 HYDROXYETHYL ACRYLATE / SODIUM ACRYLOYLDIMETH YLTAURATE COPOLYMER 0.7 AMMONIUM ACRYLOYLDIMETHYLTAURATE / VP COPOLYMER 1.2 SODIUM POLYACRYLATE 1.3 XANTHAN GUM 0.3 POLY ACRYLATE CROSSLINKED-6 COPOLYMER 0.8 ALUMINUM STARCH OCTENYLSUCCINATE 1 1 (i) Active ingredient 4-T-BUTYLCYCLOHEXANOL 1.1 1.1 1.1 (J) Water soluble solvent T-BUTYL ALCOHOL, CAPRYLYL GLYCOL, PENTYLENE GLYCOL AND / OR PROPYLENE GLYCOL 4.5 4.2 13.5 (k) Silicone DIMETHICONE 0.5 (1) Miscellaneous Emulsifiers SORBITAN ISOSTEARATE (HLB = 4.7) 0.04 0.3 SORBITAN OLEATE (HLB = 4.3) 0.1 DISODIUM ETHYLENE DISULFATE DL COCAMIDE PEG-15 0.5 Other miscellaneous emulsifiers / surfactants, salts, preservatives, pH adjusting agents, perfumes, colorants, chelating agents, extracts, fillers, absorbents, and / or additional skin active ingredients, etc. <4 <4 <4 Stability NO N NO N NO Example 3

[0211] The compositions of Example 1 and Example 2 were subjected to stability studies and evaluated visually for phase separation and examined at room temperature. microscope for particle formation. The compositions were analyzed during the initial manufacture of the composition (To). The compositions were analyzed again after 10 days of freeze-thaw testing. For the freeze-thaw tests, the compositions were placed in a stability chamber and subjected to a temperature fluctuation at 12-hour intervals. For 12 hours, the compositions were kept at -20 °C. During the For the next 12 hours, the compositions were kept at 25°C. The cycle was repeated 10 times (for 10 days). Separately, the compositions of Example 1 were evaluated after 4 weeks (1 month) in storage at 4°C, 25°C, 37°C and 45°C and again after 8 weeks (2 months) at 4°C, 25°C, 37°C and 45°C and visually evaluated for phase separation and examined microscopically for particle formation.

[0212] The compositions of the invention were judged to be stable ("O") (yes) since they did not visually phase separate and form particles. The Comparative Compositions (C1 to C-3) were judged to be unstable ("N") (no) since they phase separated and / or formed particles. The data show the importance of the one or more nonionic emulsifiers selected from glyceryl esters having HLB of about 3 to about 8 (c) and the importance of the one or more nonionic emulsifiers having HLB of about 16 to about 18 (d). If one of these types of emulsifiers is not included, the resulting composition lacks stability, i.e., exhibits phase separation and particle formation, as shown by the data for the Comparative Compositions (C1, C-2 and C-3).

[0213] The foregoing description illustrates and describes the invention. The disclosure shows and describes only the preferred embodiments, but it is understood that the invention may be used in various other combinations, modifications, and environments and may be subject to changes or modifications within the scope of the inventive concepts as expressed herein, in relation to the above teachings and / or to the skill or knowledge of the related art. The embodiments described above are further intended to explain the best modes known to the applicant and to enable others skilled in the art to use the disclosure in such embodiments, or other embodiments, and with the various modifications required by the particular applications or uses thereof. Accordingly, the description is not intended to limit the invention to the form disclosed herein. DEFINITIONS

[0214] As used herein, a "gel emulsion" is also referred to in the art as a "gel-in-emulsion." A gel emulsion is an oil-in-water emulsion, which is a composite structure of oil droplets within a gel matrix. They can be classified into emulsion-laden gels and particulate emulsion gels.

[0215] The term "HLB" refers to hydrophilic-lipophilic balance, which is a measure of the degree to which an emulsifier is hydrophilic or lipophilic, determined by calculating values ​​for different regions of the molecule, as described by Griffin, William C., "Classification of Surface-Active Agents by 'HLB'," JOURNAL OF THE SOCIETY OF Cosmetic Chemists, 1 (5): 311-26 (1949) and Griffin, William C., "Calculation of HLB Values ​​of Non-ionic Surfactants," JOURNAL OF THE Society OF Cosmetic Chemists, 5 (4): 249-56 (1954), which are incorporated herein by reference in their entirety.

[0216] “Sugar ester” as used herein means “sugar alcohol fatty acid ester” or "sugar acid fatty alcohol ester" and "sugar ether" as used herein means "sugar alcohol fatty alcohol ether".

[0217] As used herein, the terms "comprising," "having," and "including" (or "comprise," "have," and "include") are used in their open, non-limiting sense. The phrase "consisting essentially of" limits the scope of a claim to the specified materials or steps and to those that do not affect the basic and novel features of the claimed invention.

[0218] The terms “a”, “an”, “the” and “the” are understood to include the plural as well as the singular.

[0219] Thus, the term "a mixture thereof" also includes "mixtures thereof." Throughout the disclosure, if the term "a mixture thereof" is used, after a list of elements as shown in the following example where the letters A through F represent the elements: "one or more elements selected from the group consisting of A, B, C, D, E, F, or mixtures thereof." The term "a mixture thereof" does not require that the mixture include all of A, B, C, D, E, and F (although all of A, B, C, D, E, and F may be included). Instead, it indicates that a mixture of any two or more of A, B, C, D, E, and F may be included. In other words, it is equivalent to the expression "one or more elements selected from A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E and F".

[0220] Similarly, the term "a salt thereof" also includes "salts thereof." Thus, when the disclosure refers to "a member selected from the group consisting of A, B, C, D, E, F, a salt thereof, or mixtures thereof," it indicates that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0221] Salts referred to throughout the disclosure may include salts having a counterion such as an alkali metal, an alkaline earth metal, or an ammonium counterion. This list of counterions, however, is not limiting. Suitable counterions for the components described herein are known in the art.

[0222] The expression "one or more" means "at least one" and thus includes individual components as well as mixtures / combinations.

[0223] The term "plurality" means "more than one" or "two or more."

[0224] An “alkyl radical” is a saturated, linear or branched hydrocarbon-based group, in particular CrC8, more particularly C1-C6, preferably C1-C4, such as methyl, ethyl, isopropyl and tert-butyl;

[0225] An “alkoxy radical” is an alkyloxy in which the alkyl is as described above;

[0226] An “alkenyl radical” is a linear or branched, unsaturated hydrocarbon-based group, in particular C2-C8, more particularly C2-C6, preferably C2-C4, such as ethylenyl, propylenyl;

[0227] An “alkylene radical” is a divalent, linear or branched, C1-C8, in particular C1-C6, preferably C1-C4, saturated hydrocarbon-based group, such as methylene, ethylene or propylene.

[0228] Some of the various component categories identified for cosmetic compositions may overlap. In cases where an overlap may exist and the composition / product includes two overlapping components (or more than two overlapping components), an overlapping component is not more than one component. As an example, a fatty acid may be considered both a “non-triglyceride, non-aromatic fatty emollient” and a “surfactant / emulsifier.” If a particular composition / product includes both a non-triglyceride, non-aromatic fatty emollient component and a surfactant / emulsifier component, a single type of fatty acid may serve solely as the non-triglyceride, non-aromatic fatty emollient or as the surfactant / emulsifier (a single fatty acid does not serve as both the non-triglyceride, non-aromatic fatty emollient component and the surfactant / emulsifier component).

[0229] All percentages, parts and ratios herein are based on the total weight of the compositions of the present invention, unless otherwise indicated.

[0230] All ranges and values ​​disclosed herein are inclusive and combinable. For example, any value or point described herein that falls within a range described herein may serve as a minimum or maximum value for deriving a subrange, etc. Furthermore, all ranges provided are intended to include each specific range within, and combination of subranges between, the given ranges. Thus, a range of 1 to 5 specifically includes points 1, 2, 3, 4, and 5, as well as subranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.; and points of 1, 2, 3, 4 and 5 includes the ranges and sub-ranges of 1 to 5, 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

[0231] Except in working examples, or unless otherwise indicated, all numbers expressing amounts of ingredients and / or reaction conditions may be modified by the term "about", whether expressly stated or not.

[0232] Further, all numbers are intended to represent exact values ​​as additional embodiments, whether or not modified by the term "about." For example, "an amount of about 1%" may be modified to refer to exactly 1%. As a further example, "an amount of 1%" may be modified to refer to "about 1%." Unless otherwise indicated, the term "about" is understood to encompass a range of + / - 10% of the stated number. However, in some embodiments, the term may be defined to encompass narrower ranges, for example, + / - 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, and 10% of the stated number.

[0233] The terms "surfactants" and "emulsifiers" include salts of surfactants and emulsifiers even if not explicitly stated. That is, whenever the disclosure refers to a surfactant or emulsifier, it is intended that salts are also encompassed to the extent that such salts exist, even though the specification may not specifically refer to a salt (or may not refer to a salt at every occurrence of the disclosure), for example, by using a phrase such as "a salt thereof" or "salts thereof." Sodium and potassium are common cations that form salts with surfactants and emulsifiers. However, additional cations such as ammonium ions, or alkanolammonium ions such as monoethanolammonium or triethanolammonium ions, may also form surfactant salts.

[0234] The term "substantially free" or "essentially free" as used herein indicates that the specific material may be present in small amounts that do not materially affect the basic and novel features of the claimed invention. For example, there may be less than 2% by weight of a specific material added to a composition, based on the total weight of the composition (provided that an amount less than 2% by weight does not materially affect the basic and novel features of the claimed invention). Similarly, a composition "substantially free" or "essentially free" of a specified material may include less than 1.5% by weight, less than 1% by weight, less than 0.5% by weight, less than 0.1% by weight, less than 0.05% by weight, or less than 0.01% by weight, or no amount of the specified material.The term "substantially free" or "essentially free" as used herein may also mean that the specific material is not added to the composition but may still be present in a . raw material that is included in the composition.

[0235] Furthermore, any components that are positively stated in the present disclosure may be negatively excluded from the claims, for example, a claimed composition may be "free", "essentially free" (or "substantially free") of one or more components that are positively stated in the present disclosure. For example, silicones may optionally be included in cosmetic compositions but in some cases the compositions may be free or essentially free of silicones. Silicones are synthetic polymers consisting of repeating units of siloxane, silicon and elemental oxygen, combined with other elements, most commonly carbon and hydrogen. Thus, silicones are also referred to as polysiloxanes.In some cases, the cosmetic compositions of the present case may be free or essentially free of dimethicones, amodimethicones, dimethiconols, cyclosiloxanes, siloxanes, etc.

[0236] All publications and patent applications cited in this specification are hereby incorporated by reference, and for all purposes, as if each individual publication or patent application were specifically and individually indicated as being incorporated by reference. In the event of any inconsistency between this disclosure and any publication or patent application incorporated herein by reference, this disclosure shall prevail.

Claims

Claims

1. A cosmetic composition comprising: (a) about 12 to about 35% by weight of hydroxypropyl tetrahydropyrantriol; (b) water; (c) about 0.1 to about 5% by weight of a nonionic emulsifier selected from glyceryl esters having a hydrophilic-lipophilic balance (HLB) of about 3 to about 8; (d) about 0.1 to about 5% by weight of one or more nonionic emulsifiers having an HLB of about 16 to about 18 comprising one or more ethoxylated emulsifiers selected from ethoxylated fatty acids, ethoxylated sorbitan fatty esters, and mixtures thereof; (e) about 0.1 to about 5% by weight of one or more nonionic emulsifiers having an HLB of about 9 to about 15 selected from alkyl polyglucosides, polyglycerol-based emulsifiers, sorbitan fatty esters, fatty sugar esters, polyol fatty esters, glyceryl fatty esters, ethoxylates thereof, or a mixture thereof;(f) about 1 to about 10% by weight of one or more fatty alcohols; (g) about 5 to about 20% by weight of one or more fatty compounds; (h) one or more thickening polymers; and wherein the composition is an oil-in-water emulsion, preferably a gel emulsion, and all weight percentages are based on the total weight of the cosmetic composition.;

2. The composition of claim 1, wherein the one or more glyceryl esters are selected from glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl lanolate, glyceryl laurate, glyceryl myristate, glyceryl palmitate lactate, glyceryl stearate, glyceryl dioleate, glyceryl distearate, glyceryl laurate, or a mixture thereof.

3. A composition according to claim 1 or 2, further comprising: (i) about 0.1 to about 5% by weight of 4-tert-butylcyclohexanol.

4. A composition according to any preceding claim, wherein the one or more thickening polymers include one or more taurate copolymers.

5. Composition according to any one of the preceding claims, wherein the composition does not visually phase separate or form particles for at least 2 weeks in storage at 4°C, 25°C, 37°C and / or 45°C; and / or the composition does not visually phase separate or form particles during at least 10 freeze-thaw test cycles, wherein the freeze-thaw tests comprise placing the cosmetic composition in a stability chamber and subjecting it to a temperature fluctuation at 12-hour intervals, for a first 12-hour interval at -20°C followed by a second 12-hour interval at 25°C.

6. A composition according to any preceding claim having a viscosity of about 20,000 to about 80,000 cPa.s at 25°C, and a shear rate of 1 s 1 at 25°C.

7. A kit comprising the cosmetic composition according to any one of the preceding claims and one or more additional skin treatment compositions, wherein the cosmetic composition and each of the one or more skin treatment compositions are contained separately.

8. A method of treating the skin comprising applying the cosmetic composition according to any one of claims 1 to 6 to the skin.