Powdered composition for dietary supplement

Abstract

The present invention relates to: a powdered composition for dietary supplement containing imperatively hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or derivatives, vitamin E or one of its derivatives, a zinc salt, a copper salt and one or more organic selenium derivatives; the use of said composition as an oral dietary supplement for improving the health and beauty of the skin and scalp as well as preventing their aging, to be consumed orally after dilution in water or any beverage containing water.the use of said composition as an oral food supplement combined with the use of one or more cosmetic products administered topically to the skin, scalp or hair comprising themselves hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or derivatives, vitamin E or one of its derivatives, a zinc salt and a copper salt.

Description

Title of the invention: Powdered composition for food supplement

[0001] The present invention relates to: • a powder composition for food supplement containing hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or derivatives, vitamin E or one of its derivatives, a zinc salt, a copper salt and one or more organic selenium derivatives. • the use of said composition as an oral food supplement for the improvement of the health and beauty of the skin and scalp as well as the prevention of their aging, to be consumed orally after dilution in water or any beverage containing water. • the use of said composition as an oral food supplement combined with the use of one or more cosmetic products administered topically to the skin, scalp or hair; cosmetics themselves comprising hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or derivatives, vitamin E or one of its derivatives, a zinc salt and a copper salt.

[0002] Food supplements are intended to complement a normal diet by providing / supplementing vitamins, minerals, and other substances with a nutritional or physiological effect. These products are available in the form of tablets, capsules, powder sachets, ampoules, or bottles. From a regulatory standpoint, they are not medicinal products and are therefore not intended for the prevention or treatment of any human disease.

[0003] Market research shows that over the past two decades, more and more consumers have turned to food supplements to preserve their health and ensure their well-being, seeking: • to address certain nutritional deficiencies, without ever replacing a balanced diet. • to eliminate or alleviate certain everyday discomforts and ailments, such as stress or difficulty falling asleep. • to contribute to good general health by reducing certain risk factors and maintaining the most optimal physiological balance possible.

[0004] Among the benefits sought in the consumption of food supplements, the treatment of the skin to improve its properties and radiance (hydration, elasticity, wrinkles, etc.), but also to fight against its aging, constitutes a solution that is increasingly popular with consumers.

[0005] Collagen, a structural protein in the human body that plays an essential role in skin by ensuring its strength and elasticity, has become a key ingredient in dietary supplements for improving skin quality. Hydrolyzed collagen is made from collagen fibers and is present in the form of small peptides and free amino acids with molecular weights ranging from 1 to 10,000 Daltons. Once ingested, hydrolyzed collagen crosses the intestinal barrier to reach the different layers of the skin. In the skin, the amino acids act as building blocks for collagen production. The collagen peptides, for their part, adhere to fibroblasts as ligands. Hydrolyzed collagen thus stimulates the synthesis of collagen, elastin, and hyaluronic acid in the skin.

[0006] Similarly, the beneficial actions of vitamin C and vitamin E are well established in the treatment of skin quality, making them key ingredients in the composition of food supplements.

[0007] However, the presence of an ingredient known for its beneficial activity on the skin in the list of constituents of a food supplement does not in itself guarantee the molecule's effectiveness with regard to the intended purpose. The exact formulation of the food supplement therefore plays a determining role in the action or inaction of the various ingredients constituting that food supplement.

[0008] Thus, based on this observation, the following problems exist in the design and use of a food supplement with the objective of being as effective as possible while being able to ensure an appropriate level of safety and tolerance during its consumption, without forgetting that the form of administration must be satisfactory so that the consumer agrees to take the product while respecting its dosage: • The potential chemical instability of the ingredients included in the composition could render these ingredients completely ineffective in achieving their intended action. This chemical instability can potentially generate other compounds that may induce varying degrees of toxicity, thereby reducing the overall safety of the composition. This is typically the case with vitamin C, a molecule known for its high instability in water, but also in the stomach due to its acidic conditions combined with a body temperature of 37°C. • The hydrophilic and lipophilic nature of ingredients, sometimes mixed within the same composition despite their opposing properties, and therefore the solubility or insolubility in water or any water-containing beverage of certain ingredients, significantly limits their ability to be transported orally, in a water-rich environment, to the targeted area of ​​the body. Here too, this hydrophilic / lipophilic nature of the ingredient can render it completely ineffective for its intended purpose within the composition, due to the composition's inability to transport it to its intended location in the body. This is the case with vitamin E, which is insoluble in water. • The complexity of creating the necessary conditions for the composition of the dietary supplement so that it can be delivered / transported to the absorption site(s) of each target molecule (often in the intestine), after passing through the stomach, in order to be assimilated and then transferred to the organs of interest, such as the skin, in the desired molecular form and in sufficient quantity. Thus, many commercial compositions currently on the market have formulations that render them unable to target the intended organ(s), and therefore to fulfill their claimed purpose. • The formulation of a composition containing only molecules beneficial to the intended purpose (i.e., the treatment of the skin and scalp), in only the appropriate quantities, to ensure the greatest possible tolerance, and therefore with a toxicological profile adapted to the intended use and consumers (for example, the needs of a child and an elderly person can be significantly different). Thus, the maximum daily doses of each ingredient in the composition must be respected in order to ensure maximum safety of the consumed product. • a satisfactory form of oral administration, including the texture and / or taste of the food supplement, so as not to make the composition unsuitable for use by the consumer. • the presence or absence of stabilizing agents and / or preservative agents and / or surfactants required in the formulation to achieve its objective; additional compounds altering more or less the toxicological profile of the composition, without providing any tangible benefit / performance to the food supplement.

[0009] In this context, the present invention aims to describe a new composition for a food supplement in powder form containing necessarily hydrolyzed collagen, vitamin C or one of its salts, or one of its derivatives, and vitamin E or one of its derivatives, and other ingredients, while addressing the problems described above, in particular by aiming for a better level of performance and safety for the oral food supplement.

[0010] The composition for an oral food supplement according to the invention is in the form of a dry powder and it necessarily comprises hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or one of its derivatives, vitamin E or one of its derivatives, a zinc salt, a copper salt and one or more organic selenium derivatives, in the specific proportions of the invention.

[0011] Dry powder is understood to mean a mixture of powders of the different ingredients of the composition, containing a low overall water content, advantageously less than 10% water in total, and even more advantageously less than 5%. A low water content in the powder helps to ensure better stability of the ingredients of the composition by limiting their potential degradation by chemical means or by microbial or non-microbial agents.

[0012] In the composition according to the invention, each ingredient, itself in powder form, is included in the following proportions to ensure a daily intake, after dilution in water or any beverage containing water: • hydrolyzed collagen, preferably of marine origin, with a mass between 1,000 mg and 10,000 mg, preferably between 4,000 mg and 6,000 mg, and even more preferably between 4,500 mg and 5,600 mg. • Hyaluronic acid or one of its salts, preferably of bacterial fermentation origin, with a molecular weight between 0.9 and 2 million Daltons, and a mass between 1 mg and 500 mg, preferably between 10 mg and 100 mg, and even more preferably between 20 mg and 60 mg. Sodium hyaluronate is advantageously chosen, with a molecular weight advantageously selected between 1.0 and 1.5 million Daltons in the composition. It should be noted that a fraction of the hyaluronic acid, or one of its salts, may be cross-linked, and in this case, this fraction must not exceed 5% of the total mass of hyaluronic acid, or one of its salts. • Vitamin C or one of its salts or derivatives: ascorbic acid or one of its salts or derivatives, or L-ascorbic acid or one of its salts or derivatives, with a mass between 2 mg and 200 mg, are the advantageously chosen forms in the composition. Sodium ascorbate, potassium ascorbate, or calcium ascorbate are possible salts in the composition. Sodium ascorbyl phosphate or ascorbyl glucoside or ascorbyl palmitate or ascorbyl stearate are possible derivative forms in the composition. • Vitamin E or one of its derivatives: advantageously, the alpha-tocopherol form or one of its derivatives, or the DL-alpha tocopheryl form or one of its derivatives, with a mass between 0.5 mg and 50 mg, are the forms advantageously chosen for the composition. Alpha-tocopherol acetate or alpha-tocopherol succinate are possible derivative forms for the composition. • Zinc salt, with a mass between 0.05 mg and 50 mg. Zinc gluconate, zinc citrate, or zinc pidolate are the advantageously chosen forms in the composition. • Copper salt, with a mass between 0.01 mg and 10 mg. Copper gluconate or copper bisglycinate are the advantageously chosen forms in the composition. • the organic derivative(s) of selenium, with a mass between 0.005 mg and 0.5 mg. Amino acid forms such as selenomethionine or selenocysteine ​​are advantageously chosen in the composition.

[0013] The composition according to the invention is exclusively in powder form. This powder must be diluted in water or any water-containing beverage before oral consumption of the food supplement. This dry form ensures high stability of the water-sensitive ingredients in the composition, particularly vitamin C or one of its salts or derivatives. Consequently, the vitamin C or one of its derivatives present in the composition according to the invention is stable before consumption, thus aiming for enhanced and optimal performance of vitamin C or one of its salts or derivatives when ingested. Furthermore, the composition according to the invention is easy to store (at room temperature and requires a small storage volume, less than that of an oral food supplement already in solution form), and it benefits from a long shelf life.

[0014] The composition according to the invention does not require the addition of a stabilizing agent and / or a preservative to stabilize one or more components of the formulation, such as vitamin C or one of its salts or derivatives. This requirement allows for a better toxicological profile, and therefore better overall safety for the oral food supplement.

[0015] The composition according to the invention contains only ingredients selected for their recognized benefits in the field of skin and scalp health and beauty, with a quality compatible for food or pharmaceutical use. The quantity of each of these ingredients in the composition, including the The proportions described above must be toxicologically justifiable to ensure optimal product tolerance. Therefore, the quantity of each ingredient in the composition must be less than or equal to the maximum daily intake for humans, in accordance with the high level of safety required for this product.

[0016] The composition according to the invention is in the form of a powder to be diluted in water or any beverage containing water (for example, beverages containing water such as coffee, tea, syrup or fruit juice) before oral administration.

[0017] The resulting oral solution is very slightly viscous, making it easy for the consumer to ingest / drink. Given the large quantities of ingredients considered for the composition according to the invention (on the order of several grams), taking the food supplement in powder form, orally after dilution in water and in a single daily dose, is an advantage compared to a large capsule, which is difficult for the consumer to swallow due to its particularly large size.

[0018] As mentioned above, in the composition according to the invention, vitamin C is in powder form, and its contact with water or any water-containing beverage occurs only during the dilution of the powder in the aqueous solution, before ingestion by the consumer. It is only from this point of dissolution that the degradation of vitamin C or one of its salts or derivatives is likely to begin, and since the process of mixing the powdered food supplement with water is short (i.e., on the order of a few seconds) before oral consumption, this degradation of vitamin C or one of its salts or derivatives is very low and therefore controlled.On the other hand, as described below, surprisingly, under the specific conditions of the invention, the dissolution of the composition is accompanied by the formation of a complex which facilitates the transport of vitamin C or one of its salts or one of its derivatives in the body to the intestine while protecting it, in order to bring a maximum quantity of this key compound to the intestine, for its assimilation / absorption after passing through the stomach (an organ which strongly degrades vitamin C or one of its salts or one of its derivatives due to its acidic environment in an aqueous medium, at a temperature of 37 °C).

[0019] On the other hand, vitamin E is not known for its high sensitivity in aqueous solution, but unlike vitamin C and the other ingredients in the composition, it is lipophilic and insoluble in water. Here again, surprisingly, under the specific conditions of the invention, dissolving the composition is accompanied by the formation of a complex that allows vitamin E or one of its derivatives to be dispersed within it, without any agent No added surfactant is used to transport it, like vitamin C, from the mouth to the intestine for assimilation / absorption in the body. The absence of a surfactant in the composition contributes to the high level of safety / tolerability sought for this food supplement.

[0020] Thus, the creation of this complex is crucial for the powdered food supplement according to the invention because this complex allows for the efficient transport of all the molecules in the composition, from the mouth to the stomach, then to the intestine, where the assimilation / absorption of the various compounds takes place, before they reach the skin via the bloodstream. This complex therefore allows, in particular, the transport of the two key vitamins, vitamin C and vitamin E, or one of their derivatives. It is well documented in the scientific literature that it is specifically the combination of these two molecules (rather than one without the other) that promotes effective stimulation of collagen production by the skin itself, in order to improve its properties such as elasticity, hydration, and radiance, and thus limit the harmful effects of skin aging.Due to this specific behavior in aqueous solution, the composition according to the invention makes it possible to bring / carry a maximum quantity of the ingredients to their place of assimilation / absorption, transporting them from the mouth to the intestine and protecting them (limiting degradation in the stomach, with vitamins that are trapped at least partially in the matrix formed by the mixture).

[0021] Without wanting to be bound by an explanation, it seems that under the specific conditions of the composition, hyaluronic acid or one of its salts in association with hydrolyzed collagen, the cations of the 2 mineral salts and the organic selenium derivative(s) play the role of carrier and protector of all the ingredients of the formulation, by forming a matrix, that is to say a polymolecular network, which traps these ingredients; matrix / network formed by hydrogen bonds and ionic bonds, combined with the physical viscosity provided by the mixture.It is important to mention that this complex plays a beneficial role for both vitamin C or one of its salts and for vitamin E or one of its salts, although these two molecules have very different characteristics / properties, in particular, one (vitamin C) by protecting it from acid hydrolysis, and the other (vitamin E) by guiding / conducting it in a hydrophilic environment (without any addition of surfactant) while the molecule has a lipophilic nature.

[0022] This complex forms easily and simply upon dissolution in the aqueous solution of the food supplement according to the invention, and then through the mechanical action of simple mixing / movement (for example, using a teaspoon) in the liquid. This complex also helps to protect vitamin C by limiting its degradation during acid hydrolysis at 37°C (stomach conditions). Because the matrix, composed of hyaluronic acid or one of its salts, collagen, mineral salts, and organic selenium derivative(s), is only minimally altered by these conditions. Laboratory tests (see comparative examples) have shown that the complex retains vitamin C or one of its derivatives for better transport, thus delivering it as far as possible into the body, where it can be assimilated / absorbed.

[0023] In a particular embodiment of the invention, it has been observed that the presence of cross-linked hyaluronic acid, or one of its salts, in a fraction less than 5% of the total mass of hyaluronic acid, or one of its salts, enhances the robustness of the complex structure formed in water. A quantity exceeding this maximum fraction results in the appearance of fragments / particles in the solution, which is undesirable for the intended indication. Thus, the composition according to the invention may contain this maximum percentage of 5% of cross-linked hyaluronic acid, or one of its salts, relative to the total mass of hyaluronic acid, or one of its salts.

[0024] It should be noted that the molecular weight of hyaluronic acid has a significant impact on the complex and the texture of the oral food supplement after dilution in water. Too low a molecular weight prevents the formation of a sufficiently robust and stable complex, while too high a molecular weight makes the oral solution too viscous, and therefore less pleasant to drink because it is more pasty and leaves excessive traces of the product on the mixing container (for example, a glass), thus inducing a loss of material that is contrary to the purpose of the composition according to the invention; which is to deliver the maximum amount of ingredients to the intestine for absorption, in order to generate maximum performance at the level of the skin tissue.

[0025] In a particular embodiment of the invention, it has been observed that the presence of mannitol with a mass between 100 mg and 1,000 mg results in a more robust complex. It is assumed that this polyol strengthens the hydrogen bond network of the complex. Thus, the composition according to the invention may contain this mass between 100 mg and 1,000 mg in its formulation.

[0026] The composition may contain any other ingredient of interest in the formulation, while maintaining the primary objective of achieving a high level of safety and performance for the food supplement. Thus, in a particular embodiment of the invention, ingredients such as an anti-caking agent, a food flavoring, or a sweetener may be added to improve the organoleptic properties of the oral product and thereby make it as attractive as possible to all consumers.

[0027] The viscosity of the composition according to the invention must not be too high. Advantageously, a viscosity of less than 10 mPa·s, even more advantageously less than 1 mPa.s., is desirable for the food supplement after dilution in water.

[0028] The composition according to the invention is packaged in bottles or containers that maintain it in a dry powder form throughout its shelf life, while remaining easy for the consumer to use. Advantageously, the composition according to the invention is packaged in individual sachets, for example, sticks. Each sachet is then used to ensure a daily intake of the food supplement by pouring its contents into a container filled with water or any other beverage containing water, for example, a glass of water, before stirring and drinking it.

[0029] The composition according to the invention is advantageously diluted in a container filled with water or any water-containing beverage, and the mixing is carried out directly by the consumer with a suitable utensil, for example a teaspoon, for a few seconds, for example 5 to 10 seconds. The quantity of water to be used to dilute the composition is approximately 200 mL, and it is recommended not to use a quantity of water that is too large, exceeding 350 mL, as too much water may weaken the complex and make the drinkable food supplement slightly less effective.

[0030] The food supplement is advantageously taken as a course of treatment for approximately 3 months, with a single daily dose. The beneficial effects on the skin begin to appear by the end of the first month and intensify over time during the course of treatment.

[0031] The composition according to the invention as a drinkable food supplement is therefore used as part of an aesthetic treatment to improve the health and beauty of the skin, but also of the scalp, hair and nails.

[0032] The use of said composition as an oral food supplement is intended to improve the quality of the skin, scalp, hair and nails.

[0033] The use of said composition as an oral food supplement is ideally combined with the use of one or more cosmetic products administered topically to the skin, scalp, or hair. Advantageously, these topical products themselves comprise hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its derivatives, vitamin E or one of its derivatives, a zinc salt, and a copper salt. This combined use of an oral food supplement according to the invention and one or more topical cosmetic products can lead to synergistic results in improving the quality of the skin, scalp, or hair, and thus significantly enhanced performance. superior combined treatment for even greater consumer satisfaction. EXAMPLES

[0034] The invention will now be illustrated, in a non-limiting manner, by the following examples.

[0035] Hydrolyzed collagen of marine origin (fish), sodium hyaluronate of bacterial fermentation origin, ascorbic acid, alpha-tocopheryl, zinc gluconate, copper gluconate and organic selenium derivatives used in the following examples have a high level of purity.

[0036] UV-visible spectrophotometric measurements are carried out with a LAMBDA 365 Perkin Elmer spectrophotometer.

[0037] Example 1: Preparation of the oral food supplement from the composition according to the invention

[0038] In a glass of water containing 200 mL of water at room temperature, the composition according to the invention (see exact composition below) is introduced / added and then mixed for 10 seconds using a teaspoon. The oral solution contains no visible fragments / particles and is ready for use. Let SI be the solution thus obtained.

[0039] Exact composition: • Hydrolyzed collagen: 5,200 mg • Sodium hyaluronate (molecular weight = 1,200,000 Da): 50 mg • Ascorbic acid: 80 mg • Alpha-tocopheryl: 12 mg • Zinc gluconate: 2 mg • Copper gluconate: 0.9 mg • Selenomethionine / Selenocysteine: 0.02 mg

[0040] Example 2: Evaluation of the concentration of ascorbic acid under different conditions for the composition according to the invention and other compositions

[0041] In a 1-liter glass beaker divided into two compartments A and B of equal volume separated by a porous partition, a cellulose-based membrane (retention threshold = 10,000 Da) is placed on the porous partition so that particles smaller than 10,000 Da can pass through the partition, i.e., distribute themselves from one compartment to the other. Each compartment is equipped with a magnetic stirrer rotating at the same speed of 120 rpm. 500 mL of purified water is placed in the 1-liter beaker.

[0042] Test 1:

[0043] In compartment A, the solution SI from example 1 is placed. After 15 minutes, a sample of the liquid is taken from compartment B. Let S-El be this sample.

[0044] Test 2:

[0045] In compartment A, solution S2 is placed, prepared in the same way as solution SI of example 1 but without the hydrolyzed collagen.

[0046] After 15 minutes, a sample of the liquid is taken from compartment B. Let S-E2 be this sample.

[0047] Test 3:

[0048] In compartment A, the S3 solution is placed, prepared in the same way as the SI solution of example 1 but in which sodium hyaluronate has not been added.

[0049] After 15 minutes, a sample of the liquid is taken from compartment B. Let S-E3 be this sample.

[0050] Test 4:

[0051] In compartment A, the solution S4 is placed, prepared in the same way as the solution SI of example 1 but in which the zinc salt, copper salt and organic selenium derivatives have not been added.

[0052] After 15 minutes, a sample of the liquid is taken from compartment B. Let S-E4 be this sample.

[0053] Test 5:

[0054] In compartment A, solution S5 is placed, prepared in the same way as solution SI of example 1, but in which sodium hyaluronate with a molecular weight of 1,200,000 Da is substituted by sodium hyaluronate with a molecular weight of 30,000 Da.

[0055] After 15 minutes, a sample of the liquid is taken from compartment B. Let S-E5 be this sample.

[0056] Test 6:

[0057] The concentration of ascorbic acid is estimated by measuring the absorbance in UV-visible spectrophotometry at the wavelength of 254 nm for samples S-E1, S-E2, S-E3, S-E4 and S-E5.

[0058] The higher the measured absorbance value, the greater the concentration of ascorbic acid in compartment B, which implies that the composition tested in compartment A retained less ascorbic acid in that compartment A.

[0059] The absorbance values ​​measured for each sample are as follows: • S-El: Absorbance = 0.031 • S-E2: Absorbance = 0.234 • S-E3: Absorbance = 0.363 • S-E4: Absorbance = 0.198 • S-E5: Absorbance = 0.211

[0060] It is observed that the absorbance value is maximum in compartment B for the S-E3 sample showing that the absence of sodium hyaluronate in the composition does not allow the formation of the complex which retains the constituent ingredients, and in particular vitamin C.

[0061] On the contrary, the absorbance value is minimal in compartment B for the S-El sample showing that the composition according to the invention allows the complex to retain the constituent ingredients, and in particular vitamin C, to aim for maximum performance of the oral food supplement.

[0062] For samples S-E2, S-E4 and S-E5, it is observed that the absence of certain ingredients or a lower molecular weight of sodium hyaluronate makes it possible to obtain a complex that is significantly less robust than that relating to the composition according to the invention, and therefore a lower expected performance.

Claims

Demands

1. A food supplement composition in the form of a dry powder comprising at least hydrolyzed collagen, hyaluronic acid or one of its salts, vitamin C or one of its salts or derivatives, vitamin E or one of its derivatives, a zinc salt, a copper salt, and one or more organic selenium derivatives, characterized in that it contains: • hydrolyzed collagen with a mass of between 4,000 mg and 6,000 mg; • hyaluronic acid or one of its salts, with a mass of between 10 mg and 300 mg; • vitamin C or one of its salts or derivatives, with a mass of between 2 mg and 200 mg; • vitamin E or one of its derivatives, with a mass of between 0.5 mg and 50 mg. • a zinc salt, with a mass between 0.05 mg and 50 mg. • a copper salt, with a mass between 0.01 mg and 10 mg.• one or more organic selenium derivatives, with a mass between 0.005 mg and 0.5 mg.

2. Composition according to claim 1, characterized in that the hyaluronic acid, or one of its salts, is sodium hyaluronate.

3. Composition according to any one of claims 1 to 2, characterized in that the hyaluronic acid, or one of its salts, has a molecular weight between 0.9 and 2 million Daltons.

4. Composition according to any one of claims 1 to 3, characterized in that the hyaluronic acid, or one of its salts, is of bacterial fermentation origin and the hydrolyzed collagen is of marine origin.

5. Composition according to any one of claims 1 to 4, characterized in that vitamin C or one of its salts or one of its derivatives is ascorbic acid, sodium ascorbate, potassium ascorbate, calcium ascorbate, sodium ascorbyl phosphate, ascorbyl glucoside, ascorbyl palmitate or ascorbyl stearate.

6. Composition according to any one of claims 1 to 5, characterized in that vitamin E or one of its derivatives is alpha-tocopheryl, alpha-tocopherol acetate or alpha-tocopherol succinate.

7. Composition according to any one of claims 1 to 6, characterized in that the zinc salt is zinc gluconate, zinc citrate or zinc pidolate.

8. Composition according to any one of claims 1 to 7, characterized in that the copper salt is copper gluconate or copper bisglycinate.

9. Composition according to any one of claims 1 to 8, characterized in that the selenium derivative(s) is selenomethionine or selenocysteine.

10. Composition according to any one of claims 1 to 9, characterized in that the composition comprises mannitol with a mass between 100 mg and 1,000 mg.

11. Composition according to any one of claims 1 to 10, characterized in that only a fraction of the hyaluronic acid, or one of its salts, is cross-linked.

12. Composition according to any one of claims 1 to 11, characterized in that less than 5% of the mass of hyaluronic acid, or one of its salts, is cross-linked.

13. Composition according to any one of claims 1 to 12, characterized in that the viscosity of the food supplement, after dilution in water, is less than 10 mPa.s.

14. Composition according to any one of claims 1 to 13, for use in a skin, scalp and hair beauty enhancement treatment.

15. Composition according to any one of claims 1 to 14, for use by dilution with a volume of water not exceeding 350 mL.

16. Use of the composition according to any one of claims 1 to 15 for aesthetic applications.

17. Use of the composition according to any one of claims 1 to 15 for aesthetic applications relating to the improvement of the quality of the skin or scalp or hair.

18. Use of the composition according to any one of claims 1 to 15 for aesthetic applications as a food supplement combined with the use of one or more cosmetic products administered topically to the skin or scalp or hair.