Dithiol chelators for metal conjugation to antibodies
The formation of mercury-chelated triazole-containing antibody complexes addresses the limitations of existing methods, enhancing the stability and versatility of metal-protein conjugates for mass spectrometry and flow cytometry applications.
HK40134650APending Publication Date: 2026-07-10STANDARD BIOTOOLS CANADA INC
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- STANDARD BIOTOOLS CANADA INC
- Filing Date
- 2026-03-06
- Publication Date
- 2026-07-10
AI Technical Summary
Technical Problem
Existing methods for forming metal-protein conjugates for mass spectrometry and flow cytometry are limited in their efficiency and versatility, particularly in the use of mercury-chelated triazole-containing antibody complexes.
Method used
The formation of metal-protein conjugates is facilitated through the use of mercury-chelated triazole-containing antibody complexes, where mercury binds directly to the protein or is attached via a linker portion, enabling stable and versatile complexes for mass spectrometry and flow cytometry applications.
Benefits of technology
The proposed method enhances the stability and versatility of metal-protein conjugates, improving their performance in mass spectrometry and flow cytometry by forming robust and effective complexes.
✦ Generated by Eureka AI based on patent content.
Abstract
Metal-protein conjugates for use in mass cytometry and methods of making the same are provided. The metal-protein conjugates may have a metal directly bound to the protein, or have a metal attached to the protein through a linking moiety. The metal-protein conjugates include mercury-chelated triazole-containing antibody complexes and methods of their formation from derivatized antibodies and sulfonyl azides.
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