Anthelmintic compounds containing a thienopyridine structure.

Abstract

The present invention relates to novel anthelmintic compounds that can be used, for example, in the treatment of helminthic diseases caused by helminths such as Dirofilaria, especially Dirofilaria immitis.

Description

Technical field

[0001] The present invention relates to novel anthelmintic compounds. These compounds can be used, for example, in the treatment of insect diseases of the type caused by helminths such as Dirofilaria, especially Dirofilaria immitis. [Background technology]

[0002] Several serious animal diseases are caused by helminths, which can be classified into the following groups: a) Cestodes: for example Anaplocephala spp; Dipylidium spp; Diphyllobothrium spp; Echinococcus spp; Beneden tapeworm (Moniezia spp); Taenia spp; (b) Flukes: for example, Dicrocoelium spp; Fasciola spp; Paramphistomum spp; Schistosoma spp ); or c) nematodes: for example, Acanthocheilonema spp; Ancylostoma spp; Anecator spp; Ascaridia spp; Ascaris spp; Brugia spp; Bunostomum spp; Capillaria spp; Chabertia spp; Cooperia spp; Cyathostomum spp; Genus (Cylicocyclus spp);Cylicodontophorus spp;Cylicostephanus spp;Craterostomum spp;Dictyocaulus spp;Dipetalonema spp; Dirofilaria spp; Dracunculus spp; Enterobius spp; Filaroides spp; Habronema spp; Haemonchus spp; Heterakis spp; Chios Hyostrongylus spp; Metastrongylus spp; Meullerius spp; Necator spp; Nematodirus spp; Nippostrongylus spp; Oesophagostomum Onchocerca spp; Onchocercidae spp; Ostertagia spp; Oxyuris spp; Parascaris spp; Stephanurus spp; Strongylus (Strongylus spp); Syngamus spp; Toxocara spp; Strongyloides spp; Teladorsagia spp; Toxascaris spp; Trichinella spp; Trichlis Trichostrongylus spp; Triodontophorous spp; Uncinaria spp and / or Wuchereria spp.

[0003] The helminths mentioned above cause helminth diseases, also known as worm infections. These helminths often live in the gastrointestinal tract of their host, but can also burrow into other organs and induce physiological damage. For example, Ascaridia spp has been reported to cause partial or even complete obstruction of the gastrointestinal tract in affected animals, especially feathered animals such as birds, from infection of the small intestine. Additionally, another helminth, Haemonchus spp., is known to affect animals such as sheep and goats, and such parasitisms often involve quaternary parasites to suck blood from the host. Adheres to the gastric mucosa. Therefore, affected animals can develop anemia and shortness of breath. Furthermore, Oesophagostomum spp is known to cause nodule formation in the intestines of its infected hosts, which can lead to dysentery.

[0004] Additionally, heartworm disease, also known as cardiovascular dirofilariasis, is a serious and often fatal disease that can affect internal organs such as the lungs and heart in pets and certain mammals. The disease is caused by the nematode Dirofilaria immitis, which in its adult state can have a length of up to about 30 centimeters and a thickness of about 1 millimeter. These worms live in the heart, lungs and associated blood vessels, causing severe lung disease, heart failure, and damage to other internal organs such as the liver and kidneys. Heartworm infections can therefore result in host complications and typically death of the host.

[0005] Heartworm disease is known to affect pets, particularly dogs, which are considered the definitive host. However, cats, ferrets, wolves, coyotes, jackals, foxes, bears, sea lions, and in very rare cases even humans (zoonosis) can be affected by heartworm.

[0006] Heartworms must go through different stages before becoming adults that live in a host animal. Mosquitoes play an essential role in the heartworm life cycle as they are required as intermediate hosts. Adult female heartworms living in infected hosts produce larvae called microfilaria, which can circulate in the bloodstream for up to two years and are ingested by blood-sucking mosquitoes. When a mosquito bites into such an infected host and takes in the blood, the microfilariae are picked up and begin to develop in the mosquito, thereby leading to the first and second larval stage (L) of heartworm development. 1 ) and (L 2 ) occurs inside the mosquito's body. The larva is in the third larval stage (L 3 ) and become the infective larval stage, and when the mosquito finds and bites a host, these infective larvae are deposited on the surface of the host's skin and enter the new host through the mosquito's bite, where they remain at the site of the bite. It's under the skin. After a short period of about two weeks for further growth, they reach the fourth larval stage (L 4 ) and migrates to the muscles of the chest and abdomen. After 45-60 days of infection, the larvae become immature adults (fifth larval stage; L 5 ), 75 to 120 days after infection (mosquito bite), these immature heartworms enter the bloodstream and are transported to the heart and pulmonary system, where they increase significantly in size over the next approximately three months. . By 7 months after infection (mosquito bite), the adults mate and the females begin to give birth to the microfilariae described above. Adult heartworms can survive for up to about 7 years in dogs and up to about 3 years in cats. Because of the lifespan of these worms, each mosquito season can increase the number of heartworms in infected pets.

[0007] It has been reported that the widespread use of anthelmintic compounds has resulted in the development of highly resistant insect populations. The development of this resistance to known anthelmintics is believed to pose problems for the successful treatment of the disease(s) mentioned above.

[0008] WO 2018 / 087036 and WO 2019 / 025341 both describe compounds considered to be anthelmintics, namely the following structures: [ka] discloses quinoline 3-carboxamide derivatives of, where the residue R 1 ,R 2 ,R 3 ,R 4 ,R 5 ,R 6 , A and Q are defined correspondingly.

[0009] Furthermore, WO 2017 / 178416 describes a compound considered to be an anthelmintic, namely the following structure: [ka] discloses pyrazolopyrimidine derivatives of the formula, in which the residue R 0 ,R 1 ,R 2 ,R 3 ,R 4 , Q, X and Y and the variable n are correspondingly defined.

[0010] The molecule is considered a modulator of the Caenorhabditis elegans calcium-activated potassium channel slo-1, which is a helminth ortholog of the human KCa1.1 channel encoded by the KCNMA1 gene (potassium-calcium activated channel subfamily M alpha 1). ) (KCa1.1 and KCNMA1 are often used interchangeably). Slo-1 exhibits calcium-activated potassium channel activity and voltage-gated potassium channel activity. Slo-1 channels play an important role in the neuromuscular system and especially in secretory cells. Accordingly, slo-1 modulators have been reported to be involved in several processes including behavioral responses to ethanol, locomotion and pharyngeal pumping. More specifically, they interfere with neuromuscular transmission, cause flaccid paralysis, and also affect feeding and egg production. Furthermore, they retard the development of larvae and adults of the corresponding helminths.

[0011] Nevertheless, new active pharmaceutical ingredients capable of combating infections by helminths are still urgently needed, especially in view of the development of resistance to known anthelmintic compounds. [Prior art documents] [Patent document]

[0012] [Patent Document 1] International Publication No. 2018 / 087036 [Patent Document 2] International Publication No. 2019 / 025341 [Patent Document 3] International Publication No. 2017 / 178416 [Summary of the invention] [Problem to be solved by the invention]

[0013] It is therefore an object of the invention to overcome one or more of the disadvantages of the prior art.

[0014] It is an object to provide novel anthelmintic compounds that can be used to combat infectious diseases in mammals, especially pets such as cats and dogs, especially dogs. In particular, Ostertagia ostertagi, Cooperia oncophora, Cooperia punctata, Trichostrongylus axei, Haemonchus placei, Haemonchus contortus contortus), Nematodirus helvetianus, Nematodirus spathiger, Trichostrongylus colubriformis, Trichostrongylus circumcincta, Oesophagostomum venulosum , Chabertia ovina, Dictyocaulus viviparous, Dictyocaulus filaria, Dirofilaria immitis, Dirofilaria repens;b) Flukes: Fasciola hepatica, Fascioloides magna, Dicrocoelium dentriticum, Paramphistomum cervi, (c) Cestode: Monesia expanda The aim is to provide new anthelmintic compounds that can be used to combat infections in mammals by parasitic helminths such as Monezia expansa, in particular Dirofilaria immitis (dog heartworm). .

[0015] Another objective is to provide novel anthelmintic compounds that can be used to combat infectious diseases in mammals, and that these compounds can be used to combat infectious diseases in mammals, particularly cats and dogs, especially dogs. Compatible with anti-parasitic treatment. In particular, it is an object to provide novel anthelmintic compounds that can be used to combat infectious diseases in pets such as cats and dogs and can be administered orally or topically.

[0016] More specifically, it can be used to combat infections in mammals caused by parasitic helminths, in particular infections caused by Dirofilaria immitis (heartworm), but it can also be used to combat infections in mammals due to undesirable side effects. The aim is to provide new anthelmintic compounds that do not have an adverse effect on the human body.

[0017] Furthermore, it is an object that the new anthelmintic compounds can be used with different treatment schedules, especially monthly or longer treatment schedules. [Means to solve the problem]

[0018] Surprisingly, a compound according to formula (I) [ka] During the ceremony, R 1 is independently, Hydrogen, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy, C 1-6 -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR 2 R 3 , COOH, C(=O)OR 4 , S.R. 4 ,SOR 4 , S.O. 2 R 4 , S.O. 2 NR 5 R 6 and C(=O)NR 5 R 6 , Each C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy or C 1-6 -Alkyl mercapto is C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy, C 1-6 -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR 2’ R 3’ ,C(=O)OR 4’ , S.R. 4’ ,SOR 4’ , S.O. 2 R 4’ , S.O. 2 NR 5’ R 6’ and C(=O)NR 5’ R 6’ optionally substituted with one or more substitutions independently selected from the group consisting of R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy-C 1 - 6- Alkyl, C 3-10 -C substituted with cycloalkyl 1 - 6 -C substituted with alkyl, 5-10 membered heterocyclyl 1 - 6 -Alkyl, C 6-10 -C substituted with aryl 1 - 6 -C substituted with alkyl and 5-10 membered heteroaryl 1 - 6 -Alkyl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms being N, selected from S and O, Each C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy-C 1 - 6-Alkyl, C 3-10 -C substituted with cycloalkyl 1 - 6 -C substituted with alkyl, 5-10 membered heterocyclyl 1 - 6 -Alkyl, C 6-10 -C substituted with aryl 1 - 6 -C substituted with alkyl or 5-10 membered heteroaryl 1 - 6 -alkyl or R 2 and R 3 The heterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -Alkoxy, carbonyl, halogen, cyano, hydroxy, mercapto, NR 2’’ R 3’’ ,C(=O)OR 4’’ , S.R. 4’’ ,SOR 4 , S.O. 2 R 4’’ , S.O. 2 NR 5’’ R 6’’ and C(=O)NR 5’’ R 6’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 - independently selected from alkyl, R 2’ ,R 3’ ,R 4’ ,R 5’ and R 6’ is hydrogen and C 1-6 - independently selected from alkyl, R 2’’ ,R 3’’ ,R 4’’ ,R 5’’ and R 6’’ is hydrogen and C 1-6 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy, C 1-6 -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR 8 R 9 , COOH, C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 , S.O. 2 NR 11 R 12 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy or C 1-6 -Alkyl mercapto is C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy, C 1-6 -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , S.R. 10’ ,SOR 10’ , S.O. 2 R 10’ , S.O. 2 NR 11’ R 12’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy-C 1 - 6- Alkyl, C 3-10 -C substituted with cycloalkyl 1 - 6 -C substituted with alkyl, 5-10 membered heterocyclyl 1 - 6 -Alkyl, C 6-10 -C substituted with aryl 1 - 6 -C substituted with alkyl and 5-10 membered heteroaryl 1 - 6 -Alkyl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy-C 1 - 6- Alkyl, C 3-10 -C substituted with cycloalkyl 1 - 6 -C substituted with alkyl, 5-10 membered heterocyclyl 1 - 6 -Alkyl, C 6-10 -C substituted with aryl 1 - 6 -C substituted with alkyl or 5-10 membered heteroaryl 1 - 6 -alkyl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -Alkoxy, carbonyl, halogen, cyano, hydroxy, mercapto, NR 8’’ R 9’’ ,C(=O)OR 10’’ , S.R. 10’’ ,SOR 10’’ , S.O. 2 R 10’’ , S.O. 2 NR 11’’ R 12’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 Hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 is hydrogen or C 1 - 3 is alkyl, R 14 is hydrogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy, NR 14’ R 14’’ and R 14’ and R 14’’ is independently C 1-3 -alkyl, or R 13 and R 14 together with the atoms to which they are attached form 5- or 6-carbon atoms containing saturated rings, where saturated rings contain one or more C 1-3Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 May be replaced with - or -S-, or R 13 and R 14 Together with the atoms to which they are attached, they form 5- or 6-carbon atoms containing unsaturated rings, where the unsaturated rings contain one or more C 1-3 -alkyl and / or one or more of the ring-forming carbon atoms may be replaced by -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 is C 6-10 -aryl and 5-10 membered heteroaryl, Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 2-6 -alkenyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy, C 1-6 -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR 20 R 21 ,C(=O)OR 22 , S.R. 22 ,SOR 22 ,S.O. 2 R 22 ,S.O. 2 NR 23 R 24 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy-C 1 - 6- Alkyl, C 6-10 -C substituted with aryl 1 -C 6 -C substituted with alkyl, 5-10 membered heteroaryl 1 - 6 -Alkyl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heteroheterocycle having from 3 to 12 ring atoms, with 0, 1, 2 or 3 further ring atoms selected from N, S and O, Each C 1-6 -Alkyl, C 2-6 -alkenyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -alkoxy or C 1-6 -Alkylmercapto or R 20 and R 21 The heteroheterocycles formed by together with the N atoms to which they are attached, C 1-6 -Alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -Alkoxy, carbonyl, halogen, cyano, hydroxy, mercapto, NR 20’ R 21’ ,C(=O)OR 22’ , S.R. 22’ ,SOR 22’ ,S.O. 2 R 22’ ,S.O. 2 NR 23’ R 24’ , and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl, R 25 is hydrogen and C 1-6 - independently selected from alkyl, At least one of the objectives can be met by providing compounds of formula (I) or stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures thereof. discovered.

[0019] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R 6 is hydrogen and C 1-6 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6- independently selected from alkyl.

[0020] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy and halogen independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2’ and R 3 ’ is hydrogen and C 1-3 - independently selected from alkyl.

[0021] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride, especially hydrogen and methyl independently selected from the group consisting of.

[0022] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, and 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl.

[0023] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or 3 one further ring atom is selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl and 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen or C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-6 - independently selected from alkyl.

[0024] R 8’’ is R 9’’ and hydrogen or C 1-6 - independently selected from alkyl.

[0025] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0026] In one embodiment of the invention and / or its embodiments, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, hydroxyethylamino, 2 -Hydroxyethylmethylaminomethoxyethylamino, cyclopropylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3, 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl and 4,4-difluoropiperidin-1yl independently selected from the group consisting of.

[0027] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 May be replaced with - or -S-, or R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -Alkyl.

[0028] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- May be replaced or R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is CR 17 and R 17 is hydrogen; A4 is CR 18 and R 18 is hydrogen.

[0029] In one embodiment of the invention and / or its embodiments, 0, 1 or 2 of the residues A1, A2, A3 and A4 are N.

[0030] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 1-6 -alkoxy, C 3-10 -cycloalkyl or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atom to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 6-10 -aryl, 5-10 membered heteroaryl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 are independently hydrogen and C 1-6 - selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’is hydrogen and C 1-6 - independently selected from alkyl.

[0031] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of; Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0032] In one embodiment of the invention and / or its embodiments, R 19 is C 6-10 - is an aryl; Here, C 6-10 -aryl is C 1-6 - optionally substituted with one or more substituents independently selected from the group consisting of alkyl, halogen, cyano and nitro, each C 1-6 -Alkyl may be optionally substituted with one or more halogens.

[0033] In one embodiment of the invention and / or its embodiments, R 19 is C 6-10 - is an aryl; Here, C 6-10 -aryl is Fluoride, Bromide Chloride, Trifluoromethoxy and Trifluoromethyl phenyl substituted with 1, 2 or 3 substituents independently selected from the group consisting of

[0034] In one embodiment of the invention and / or its embodiments, R 25 is hydrogen.

[0035] In one embodiment of the invention and / or its embodiments, the compound according to formula (I) is present in the form of the (S)-enantiomer.

[0036] Furthermore, the present invention relates to a method for preparing compounds according to formula (I), To obtain a compound according to the compound of formula (I), Compound of formula (A) [ka] , a compound of formula (B) [ka] including a step of reacting with In the formula, R 1 ,R 7 ,R 13 ,R 14 ,A1,A2,A3,A4,R 19 and R 25 is defined as in any one of the embodiments described herein.

[0037] Furthermore, the present invention - a compound according to formula (I) as defined in any one of the embodiments described herein; - one or more physiologically acceptable excipients; Provided is a veterinary composition comprising:

[0038] In one embodiment of the invention and / or its embodiments, the one or more physiologically acceptable excipients are carriers, fillers, flavoring agents, binders, antioxidants, buffers, sugar components, lubricants. agents, surfactants, stabilizers, flow agents, disintegrants and preservatives and mixtures thereof.

[0039] Furthermore, the invention provides a compound according to formula (I) as defined in any one of the embodiments herein or a veterinary composition according to the invention for use as a medicament.

[0040] Furthermore, the invention provides compounds according to formula (I) or veterinary compositions according to the invention for use in the treatment of disorders / diseases caused by helminths.

[0041] In one embodiment of the invention and / or its embodiments, the disease is heartworm disease.

[0042] In one embodiment of the invention and / or embodiments thereof, the helminth is Dirofilaria immitis. [Details for carrying out the invention]

[0043] Compounds according to formula (I) or stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures thereof may be used in the production of Ascaridia galli, Haemonchus contortus, Esophagostomum. It has been found useful in the treatment of helminth diseases such as helminths such as Oesophagostomum dentatum and disorders / diseases caused by Dirofilaria immitis. In particular, the compounds according to the invention and / or any embodiments thereof are useful in the treatment of heartworm disease. Optionally, the compounds according to the invention and / or any embodiment thereof are useful for the treatment of disorders / diseases caused by nematodes, in particular Dirofilaria immitis, The disorder / disease caused by canine heartworm disease is heartworm disease.

[0044] Advantageously, the compounds according to the invention and / or any embodiment thereof are effective against helminths such as Dirofilaria immitis, but not against helminths such as Acinetobacter baumannii or Staphylococcus spp. It is not effective against bacteria that are particularly relevant to the health of mammals, especially dogs, such as Streptococcus spp) or Streptococcus spp.

[0045] The inventors have found that the compounds of the present invention meet such needs and are therefore very useful in the treatment (and prevention) of diseases caused by helminths, such as heartworm disease.

[0046] The following abbreviations and definitions are used throughout this application.

[0047] Generally, reference to a particular element is meant to include all isotopes of that element. For example, if a group is defined to contain hydrogen or a residue is hydrogen, it also includes deuterium and tritium.

[0048] "C 1-6 The term "-alkyl" refers to an alkyl group having 1 to 6 carbon atoms without heteroatoms. The term therefore includes straight chain alkyl groups such as methyl, ethyl, propyl, butyl, pentyl and hexyl. The term also includes branched isomers of straight-chain alkyl groups, including, but not limited to, the following, provided by way of example: -CH(CH 3 ) 2 , -CH(CH 3 )(CH 2 CH 3 ), -CH(CH 2 CH 3 ) 2 , -C(CH 3 ) 3 ,-CH 2 CH(CH 3 ) 2 ,-CH 2 CH(CH 2 CH 3 ) 2 ,-CH 2 C(CH 3 ) 3 , -CH(CH 3 )CH(CH 3 )(CH 2 CH 3 ), -CH 2 CH 2 CH(CH 3 ) 2 ,-CH 2 CH 2 CH(CH 3 )(CH 2 CH 3 ), -CH 2 CH 2 C(CH 3 ) 3 etc. Therefore, “C 1-6 The term "alkyl" refers to primary alkyl groups having 1 to 6 carbon atoms, secondary alkyl groups having 3 to 6 carbon atoms, and tertiary alkyl groups having 4 to 6 carbon atoms. Contains alkyl groups.

[0049] Correspondingly, “C 1-3 The term "-alkyl" refers to an alkyl group having 1 to 3 carbon atoms without heteroatoms. The term therefore includes straight chain alkyl groups such as methyl, ethyl and propyl. The term also refers to branched chain isomers of straight chain alkyl groups, i.e. CH(CH3 ) 2 including. Therefore, “C 1-3 The term "-alkyl" includes primary alkyl groups having 1 to 3 carbon atoms, and secondary alkyl groups having 3 carbon atoms.

[0050] "C 2-6 The term "-alkenyl" means "C-alkenyl" as defined above except that at least one double bond is present between two carbon atoms. 2-6 -alkyl" refers to straight-chain and branched alkenyl groups such as those described for "alkyl". Examples include, but are not limited to, -CH=CH 2 , -C(CH 3 )=CH 2 , -CH=CH(CH 3 ), -CH=C(CH 3 ) 2 , -CH=CH(CH 3 ), -C(CH3)=CH(CH 3 ), -C(CH 2 CH 3 )H=CH 2 ,-CH 2 =CH(CH 2 CH 3 ), -CH 2 CH 2 -CH=CH 2 ,C.H. 2 CH 2 -C(CH 3 )=CH 2 ,C.H. 2 CH 2 -CH=C(CH 3 )H, -CH=CH-(CH 2 ) 2 CH 3 , -CH=C(CH 3 )-CH 2 CH 3 ,-(CH 2 ) 3 -CH=CH 2 ,-(CH 2 ) 4 -CH=CH 2 ,-(CH 2 ) 2 -CH=C(CH 3 ) 2 , butadienyl, pentadienyl, and hexadienyl.

[0051] "C 2-6 The term "-alkynyl" means "C-alkynyl" as defined above except that at least one triple bond is present between two carbon atoms. 2-6 -alkyl" refers to straight-chain and branched alkynyl groups such as those described for "alkyl". Examples include, but are not limited to, -C≡CH, -C≡CCH, among others 3 , -C≡C-CH 2 CH 3 ,-CH 2 -C≡CH, -CH(CH 3 )-C≡CH, -C(CH 3 ) 2 -C≡CH, -CH 2 -C≡CCH 3 , -CH(CH 3 )-C≡CCH 3 , -C(CH 3 ) 2 -C≡CCH 3、 -CH 2 -C≡C-CH 2 CH 3 , -CH(CH 3 )-C≡C-CH 2 CH 3 , -C(CH 3 ) 2 -C≡C-CH 2 CH 3 ,-(CH 2 ) 2 -C≡C-CH 2 CH 3 ,-(CH 2 ) 3 -C≡C-CH 3 can be mentioned.

[0052] "C 3-10 The term "cycloalkyl" refers to a non-aromatic monocyclic alkyl group having 3 to 10 carbon atoms or a non-aromatic polycyclic alkyl group having 3 to 10 carbon atoms; and consists only of hydrogen atoms. Cycloalkyl can contain fused or bridged ring systems having 3 to 10 carbon atoms. Non-aromatic monocyclic alkyl groups having 3 to 10 carbon atoms include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and the like. Non-aromatic polycyclic alkyl groups having 3 to 10 carbon atoms include, but are not limited to, adamantine, norbornane, decalinyl, 7,7-dimethyl-bicyclo[2.2.1]heptanyl, and the like.

[0053] The term "5-10 membered heterocyclyl" refers to a cyclic group in which 5-10 members (atoms) form a backbone and the backbone of the cyclic compound contains at least one carbon atom and at least one heteroatom. Point. Examples of heteroatoms include, but are not limited to, N, O and S. Unless otherwise specified herein, "5-10 membered heterocyclyl" can be a monocyclic, bicyclic, or polycyclic group that can contain fused or bridged ring systems, some of the fused ring systems being aromatic. It can be a family. The nitrogen, carbon or sulfur atom in the "5- to 10-membered heterocyclyl" may optionally be oxidized; the nitrogen atom may optionally be quaternized, and the heterocyclyl residue radical may be partially saturated. You can leave it there.

[0054] Examples of heterocyclyl groups include, but are not limited to, pyrrolinyl, 3H-pyrazolyl, 4H-pyrazolyl dihydropyridyl, pyrrolidinyl, imidazolidinyl, piperidinyl, piperazinyl, homopiperazinyl, indolinyl, quinuclidinyl, morpholinyl, thiomorpholinylthiazolodinyl, dihydrodi Thiinyl, dihydrodithionyl, tetrahydrothiophene, tetrahydrothiopyran, benzothiazinyl, e.g. 2H-1,4-benzothiazinyl, dihydrobenzothiazinyl, dihydrobenzothiazinyl, e.g. 2H-3,4-dihydrobenzothiazinyl, benzodioxolyl , for example, 1,3-benzodioxoyl, dihydroxathinyl, 1,4-oxathinyl. Further examples of heterocyclyl groups include those mentioned above in which one or more S atoms in the ring are double-bonded to one or two oxygen atoms (sulfoxides and sulfones), such as tetrahydrothiophene, tetrahydrothiophene oxide and tetrahydrothiophene-1,1-dioxide, as well as thiomorpholine, thiomorpholine oxide and thiomorpholine-1,1 dioxide.

[0055] "C 6-10 The term "aryl" refers to a group having an aromatic backbone structure in which the ring atoms are carbon atoms. In other words, “C 6-10 "Aryl" does not contain heteroatoms such as N, S, or O in the aromatic skeleton structure.

[0056] Examples of aryl groups include, but are not limited to, phenyl, biphenyl, and naphthyl.

[0057] The term "5-10 membered heteroaryl" refers to an aromatic compound in which 5-10 members (atoms) form a backbone, and the backbone of the cyclic compound contains at least one carbon atom and at least one heteroatom. Refers to a family group. Examples of heteroatoms include, but are not limited to, N, O and S. Unless otherwise specified herein, "5-10 membered heterocyclyl" may be a monocyclic or bicyclic or polycyclic group and may include fused ring systems.

[0058] Examples of 5- to 10-membered heteroaryl groups include pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidyl, pyridinyl, pyridazinyl, triazolyl, such as 1H-1, 2,3-triazolyl, 2H-1, 2,3-triazolyl, 1H-1,2,4-triazolyl and 4H-1,2,4-triazolyl, tetrazolyl, such as 1H-tetrazolyl, 2H tetrazolyl and 5H-tetrazoyl, indolyl, isoindolyl, indolinyl, indolizinyl, benzimidazolyl, quinolyl, isoquinolyl, Indazolyl, naphthyridinyl, benzotriazolyl, oxazolyl, isoxazolyl, oxadiazolyl, such as 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,5-oxadiazolyl, benzoxazolyl, benzoxadiazolyl , benzoxazinyl, e.g. 2H-1,4-benzoxazinylthiazolyl, isothiazolyl, thiadiazolyl, e.g. 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl , 1,2,5-thiadiazolyl, thienyl, benzothiazolyl, benzothiadiazolyl, benzothiazinyl, benzofuranyl, quinolinyl, isoquinoline, cinolinyl, quinasolinylquinoxalinyl, triazinyl, tetrazinyl, purinyl, pteridinyl, furyl, benzodioxolyl , including, but not limited to, 1,3-benzodioxoyl, benzothienyl, benzodithiinyl, and benzoxathiinyl.

[0059] "C 1-6 The term "-alkoxy" refers to a group based on an alkyl group having 1 to 6 carbon atoms bonded to oxygen. The alkyl group having 1 to 6 carbon atoms refers to the above “C 1-6 -Alkyl" refers to straight and branched chains such as those described for "alkyl".

[0060] Correspondingly, “C 1-3 The term "-alkoxy" refers to a group based on an alkyl group having 1 to 3 carbon atoms attached to oxygen. The alkyl group having 1 to 3 carbon atoms refers to the above “C 1-3- Refers to straight and branched chains such as those described for "alkyl".

[0061] "C 1-6 The term "-alkylmercapto" refers to a group based on an alkyl group having 1 to 6 carbon atoms attached to sulfur. Alkyl groups having 1 to 6 carbon atoms are defined above as “C 1-6 - Refers to straight and branched chains such as those described for "alkyl".

[0062] "Optionally substituted" refers to any substitution of one or more hydrogens of a group substituted with one or more of the defined substituents.

[0063] Additional amine, hydroxyl and mercapto groups can be protected. The term "protected" with respect to these groups refers to a form of these functional groups that has a protecting group to prevent the group from undesired reactions. Such protecting groups are described, for example, in Protective Groups in Organic Synthesis; Wuts, P.G.M. John Wiley&Sons, New York, NY, (53 th Edition, 2014). Protecting groups can be added or removed using the procedures described therein.

[0064] Examples of protected hydroxyl groups include, but are not limited to, silyl ethers, such as those obtained by reaction of a hydroxyl group with reagents such as, but not limited to, t-butyldimethyl-chlorosilane, trimethylchlorosilane, triisopropylchlorosilane, triethylchlorosilane, etc. silyl ethers, substituted methyl and ethyl ethers such as, but not limited to, methoxymethyl ether, methylthiomethyl ether, benzyloxymethyl ether, t-butoxymethyl ether, 2-methoxyethoxymethyl ether, tetrahydropyranyl ether, 1-ethoxyethyl ether , allyl ether, benzyl ether; and esters such as, but not limited to, benzoyl formate, formate, acetate, trichloroacetate, and trifluoroacetate.

[0065] Examples of protected amine groups include amides such as formamide, acetamide, trifluoroacetamide and benzamide; imides such as phthalimide and dithiosuccinimide; carbamates such as tert-butyloxycarbonyl (Boc); Not limited.

[0066] Examples of protected mercapto groups include, but are not limited to, thioethers such as S-benzylthioether, and substituted S-methyl derivatives such as S-4-picolylthioether, hemitio, dithio, and aminothio acetals. .

[0067] Stereoisomers include compounds that consist of the same atoms linked in the same arrangement, but the atoms are in different spatial positions. Stereoisomers include diastereoisomers and enantiomers.

[0068] "Physiologically acceptable salts" refer to salts with inorganic bases, organic bases, inorganic acids, organic acids or basic or acidic amino acids.

[0069] Examples of inorganic acids suitable for preparing (physiologically acceptable) salts include, but are not limited to, hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric and phosphoric acids. Not limited.

[0070] Examples of organic acids suitable for preparing (pharmaceutically acceptable) salts include, but are not limited to, cholic acid, sorbic acid, lauric acid, acetic acid, trifluoroacetic acid, formic acid, propionic acid, succinic acid, Glycolic acid, gluconic acid, digluconic acid, lactic acid, malic acid, tartaric acid, citric acid, ascorbic acid, glucuronic acid, maleic acid, fumaric acid, pyruvic acid, aspartic acid, glutamic acid, benzoic acid, anthranilic acid, mesylic acid, stearic acid , salicylic acid, p-hydroxybenzoic acid, phenylacetic acid, mandelic acid, embonic acid, ethanesulfonic acid, benzenesulfonic acid, toluenesulfonic acid, pantothenic acid, 2-hydroxyethanesulfonic acid, sulfanilic acid, cyclohexylaminosulfonic acid, β- Hydroxybutyric acid, galactaric acid, galacturonic acid, adipic acid, alginic acid, butyric acid, camphoric acid, camphorsulfonic acid, cyclopentanepropionic acid, dodecylsulfonic acid, glycoheptanoic acid, glycerophosphoric acid, heptanoic acid, hexanoic acid, nicotinic acid, 2- Acidic amino acids such as naphthalesulfonic acid, oxalic acid, palmoic acid, pectic acid, 3-phenylpropionic acid, picric acid, pivalic acid, thiocyanic acid, tosylic acid, undecanoic acid, aspartic acid, and glutamic acid are mentioned.

[0071] Examples of base addition salts include metal salts and organic salts.

[0072] Metal salts include, but are not limited to, alkali metal (Group Ia) salts, alkaline earth metal (Group IIa) salts, and other physiologically acceptable metal salts. Examples of such salts may be made from aluminum, calcium, lithium, magnesium, potassium, sodium, and zinc. For example, the free acid compound can be mixed with sodium hydroxide to form such a base addition salt.

[0073] Organic salts include amines such as trimethylamine, diethylamine, N,N'-dibenzyl-ethylene-diamine, chloroprocaine, ethanolamine, diethanolamine, ethylenediamine, N-methyl-glucamine, procaine, and basic amino acids such as arginine, lysine and ornithine. It can be made from.

[0074] As used herein, the term "pharmaceutically acceptable ester" refers to esters that hydrolyze in vivo, including those that readily decompose in the human body leaving behind the parent compound or a salt thereof. Suitable ester groups include, for example, pharmaceutically acceptable aliphatic carboxylic acids, especially alkanoic acids, alkenoic acids, cycloalkanoic acids and alkanes in which each alkyl or alkenyl moiety advantageously has up to 6 carbon atoms. Includes those derived from diacids. Representative examples of specific esters include, but are not limited to, formate, acetate, propionate, butyrate, acrylate, and ethyl succinate.

[0075] A solvate of a compound can be considered a compound in which an organic solvent or water is attached to the compound. Organic solvents refer to those known to those skilled in the art. When water attaches to a compound, the corresponding compound is known as a hydrate.

[0076] As used herein and commonly understood by those skilled in the art, the term "polymorph" refers to different crystalline forms of the same molecular entity. Therefore, because of their different chemical composition, the above-mentioned solvates and hydrates are not included in the definition of polymorphs and are instead referred to as "pseudopolymorphs."

[0077] The term "prodrug" refers to a compound that is rapidly transformed in vivo to yield the parent compound of formula (I) above, eg, by hydrolysis in blood. A complete discussion can be found in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the A.C.S. Symposium Series, and in Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, Listed in 1987.

[0078] As used herein, the term "pharmaceutically acceptable prodrug" means a drug that, within the scope of sound medical judgment, can be used in human and lower animal tissues without undue toxicity, irritation, allergic reactions, etc. Prodrugs of the compounds of the invention which are suitable for use in contact, commensurate with a reasonable benefit / risk ratio and are effective for their intended use, as well as possible prodrugs of the compounds of the invention. Refers to the zwitterionic form.

[0079] The present invention is based on R 1 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0080] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10-Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl.

[0081] Optionally, in one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl.

[0082] Optionally, in one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy and halogen independently selected from the group consisting of; C 1 - 6 -Alkyl and C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 -alkyl, more preferably independently selected from hydrogen and methyl.

[0083] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride, especially hydrogen and methyl independently selected from the group consisting of.

[0084] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iai), (Iaii), (Iaiii) or (Iaiv) [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 ,R 13 ,R 14 ,A1,A2,A3,A4,R 19 and R 25 is defined as in any of the embodiments described herein.

[0085] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iai), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iaii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iaiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iaiv), preferably in the form of the (S)-enantiomer.

[0086] The present invention is based on R 7 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0087] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl.

[0088] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or 3 one further ring atom is selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 Hydrogen or C 1-6 -alkyl, preferably hydrogen or C 1-3 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-6 -alkyl, preferably hydrogen or C 1-3 - independently selected from alkyl, R 8’’ and R 9’’ Hydrogen or C 1-6 -alkyl, preferably hydrogen or C 1-3 - independently selected from alkyl.

[0089] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having from 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or 3 one further ring atom is selected from N, S and O; C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 -alkyl, preferably selected from hydrogen, methyl or ethyl, R 8’’ and R 9’’ is hydrogen or C 1-3 -alkyl, preferably independently selected from hydrogen, methyl or ethyl.

[0090] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0091] In one embodiment of the invention and / or its embodiments, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, hydroxyethylamino, 2 -Hydroxyethylmethylaminomethoxyethylamino, cyclopropylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3, 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl and 4,4-difluoropiperidin-1yl, especially dimethylamino and morphilin-4-yl independently selected from the group consisting of.

[0092] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ibi), (Ibii), (Ibiii), (Ibiv), (Ibv) or (Ibvi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 13 ,R 14 ,A1,A2,A3,A4,R 19 and R 25 is defined as in any of the embodiments described herein.

[0093] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibiv) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ibvi), preferably in the (S)-enantiomeric form.

[0094] The present invention is based on R 13 and R 14 and wherein A1, A2, A3 and A4 are defined as follows:

[0095] In one embodiment of the invention and / or its embodiments, R 13 is hydrogen or C 1 - 3 is alkyl, R 14 is hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A1 is N or CR 15 and R 15 is hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ independently selected from R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0096] More suitably, in one embodiment of the invention and / or its embodiments: R 13 is hydrogen or C 1 - 3 It is an alkyl.

[0097] R 14 is hydrogen or C 1 - 3 is alkyl, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl, C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl, C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl, C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl, C 1 - 3 is alkoxy, 0, 1 or 2 of residues A1, A2, A3 and A4 are N.

[0098] More suitably, in one embodiment of the invention and / or its embodiments: R 13 is hydrogen, methyl or ethyl, preferably hydrogen or methyl; R 14 is hydrogen or methyl, preferably hydrogen, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkyl, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkyl, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkyl, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkyl, 0, 1 or 2 of residues A1, A2, A3 and A4 are N.

[0099] In one embodiment of the invention and / or embodiments thereof, the compound is according to formula (Ici). [ka] or stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures thereof, where R 1 ,R 7 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0100] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ici), preferably in the (S)-enantiomeric form.

[0101] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 May be replaced with - or -S-, or R 13 and R 14 Together with the atoms to which they are attached, they form 5- or 6-carbon atoms containing unsaturated rings, where the unsaturated rings contain one or more C 1-3 It may be substituted with -alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-.

[0102] 5 or 6 carbon atoms containing saturated or unsaturated rings (5 or 6 carbon atoms containing saturated rings are 5 or 6 carbon atoms containing saturated or unsaturated rings) 1-3 Optionally substituted with -alkyl or =O, one or more of the saturated ring carbon atoms is -NH-, -N=, N-, -O-, -S(O)-, -S(O) 2 - or -S-), as well as 5- or 6-carbon atoms containing unsaturated or unsaturated heterocycles (5- or 6-carbon atoms containing saturated rings may be substituted with one or more C 1-3 (may be substituted with -alkyl, one or more of the unsaturated ring carbon atoms may be replaced with -NH-, -N=, N-, -O-, - or -S-) An example of the structure below: [ka] including, but not limited to, residues represented by During the ceremony, [ka] indicates a bond to an amide group, [ka] represents a bond in which the abovementioned ring system is fused with an aromatic ring, including inter alia A1, A2, A3 and A4.

[0103] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0104] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- May be replaced, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0105] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0106] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Icii), (Iciii), (Iciv) or (Icv) [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0107] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Icii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iciii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iciv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Icv) and is preferably in the (S)-enantiomeric form.

[0108] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0109] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- , -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0110] R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0111] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Icvi), (Icvii) or (Icviii) [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0112] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Icvi), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Icvii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Icviii), preferably in the form of the (S)-enantiomer.

[0113] The present invention is based on R 19 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0114] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0115] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, C(=O)OR 22 ,S.O. 2 R 22 ,S.O. 2 NR 23 R 24 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -alkoxy may be substituted with one or more halogens, R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl.

[0116] In one embodiment of the invention and / or its embodiments, R 19 is C 6-10 - independently selected from aryls and 5-10 membered heteroaryls, Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -alkoxy may be substituted with one or more halogens, R 22 ,R 23 and R 24 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl.

[0117] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0118] In one embodiment of the invention and / or its embodiments, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano and nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0119] In one embodiment of the invention and / or its embodiments, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C optionally substituted with one or more halogens 1-6 -alkyl and halogen, preferably halogen may be substituted with one or more substituents independently selected from the group consisting of

[0120] Examples of 5- to 10-membered heteroaryl groups include pyrrolyl, imidazolyl, pyrazolyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-3-yl, pyrimidin- 4-yl, pyrazinyl, pyridazinyl, triazolyl, e.g. 1H-tetrazolyl, 2H tetrazolyl and 5H-tetrazoyl, indolyl, isoindolyl, indolinyl, indolizinyl, benzimidazolyl, quinolin-4-yl, quinolin-8-yl, isoquinolyl, indazolyl, naphthyridinyl, naphthyridinyl, benzotriazolyl, oxazolyl, isoxazolyl, Oxadiazolyl, such as 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl and 1,2,5-oxadiazolyl, benzoxazolyl, benzoxadiazolyl, benzoxazinyl, such as 2H-1,4-benzo Oxazinyl, thiazolyl, isothiazolyl, thiadiazolyl, such as 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl and 1,2,5-thiadiazolyl, thien-2-yl, thiene -3-ylbenzothiazolyl, benzothiadiazolyl, benzothiazinyl, benzofuranyl, quinolinyl, isoquinolinyl, cinnolinyl, quinoxalinyl, triazinyl, purinyl, pteridinyl, furyl, benzodioxolyl, such as 1,3-benzodioxoyl, Examples include, but are not limited to, benzothienyl, benzodithienyl and benzoxathienyl. Preferred are pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-3-yl, pyrimidin-4-yl, quinolin-8-yl, thien-2-yl. and thien-3-yl.

[0121] In one embodiment of the invention and / or its embodiments, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C optionally substituted with one or more halogens 1-6 -alkyl and halogen, preferably halogen substituted with one or more substituents independently selected from the group consisting of:

[0122] In one embodiment of the invention and / or its embodiments, R 19 teeth, 2,5-dichloropyridin-4-yl, 2,6-dichloropyridon-4-yl, 5-chlorothien-2-yl, 5-chlorothien-3-yl and 2,6-difluoropyridin-yl selected from the group consisting of.

[0123] In one embodiment of the invention and / or its embodiments, R 19 teeth, 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluoromethoxy Phenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoromethylphenyl , naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl selected from the group consisting of.

[0124] In one embodiment of the invention and / or its embodiments, R 19 is C 6-10 - is an aryl; C 6-10 Aryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano and nitro optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0125] In one embodiment of the invention and / or its embodiments, R 19 is C 6-10 - is an aryl; C 6-10 Aryl is Fluoride, chloride, bromide, trifluoromethyl and trifluoromethoxy phenyl substituted with 1, 2 or 3 substituents independently selected from the group consisting of

[0126] Fluoride, chloride, bromide, methyl, methoxy, dimethylamine, trifluoromethyl and trifluoromethoxy Examples of phenyl substituted with 1, 2 or 3 substituents independently selected from the group consisting of: 2-fluoro-phenyl, 3-fluorophenyl, 4-fluorophenyl, 2-chlorophenyl, 3 -Chlorophenyl, 4-chlorophenyl, 2-bromo-phenyl, 3-bromophenyl, 4-bromophenyl, 2,3-difluorophenyl, 2,4-difluorophenyl, 2,5-di-fluoro-phenyl, 3,4 -difluorophenyl, 3,5-difluorophenyl, 2,6-difluorophenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2,5-dichlorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 2, 3-dibromophenyl, 2,4-dibromo-phenyl, 2,5-dibromophenyl, 3,4-dibromophenyl, 3,5-dibromophenyl, 2,3,4-trifluorophenyl, 2,3,5- Tri-fluoro-phenyl, 3,4,5-trifluorophenyl, 2,3,4-trichlorophenyl, 2,3,5-trichlorophenyl, 3,4,5-tri-chloro-phenyl, 2,3, 4-Tribromophenyl, 2,3,5-tribromophenyl, 3,4,5-tribromophenyl, 2-chloro-3-fluorophenyl, 2-chloro-4-fluorophenyl, 2-chloro-5- Fluorophenyl, 3-chloro--2-fluorophenyl, 3-chloro-4-fluorophenyl, 3-chloro-5-fluorophenyl, 3-chloro-6-fluorophenyl, 4-chloro-2-fluorophenyl, 4 -chloro-3-fluorophenyl, 4-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-4-fluorophenyl, 3-bromo-2- Fluorophenyl, 3-bromo-5-fluorophenyl, 3-bromo-6-fluorophenyl, 4-bromo-2-chlorophenyl, 4-bromo-3-chlorophenyl, 3,4-dichloro-2-fluoro-phenyl, 3 ,5-dichloro-2-fluorophenyl, 3,5-dichloro-4-fluorophenyl, 4,5-dichloro-3-fluorophenyl, 3,4-dibromo-2-fluoro-phenyl, 3,5-dibromo -2-fluorophenyl, 4,5-dibromo-3-fluorophenyl, 2-chloro-3,4-difluorophenyl, 2-chloro-3,5-difluorophenyl, 3-chloro-4,5-difluorophenyl, 3 -chloro-5-6-difluorophenyl, 3,4-dibromo-2-chlorophenyl, 3,5-dibromo-2-chlorophenyl, 4,5-dibromo-3-chlorophenyl, 2-bromo-3,4-difluorophenyl , 2-bromo-3,5-difluorophenyl, 3-bromo-4,5-difluorophenyl, 2-bromo-3,4-dichlorophenyl, 2-bromo-3,5-dichlorophenyl, 3-bromo-4,5 -dichlorophenyl, 4-bromo-3-chloro-2-fluorophenyl, 4-bromo-2-chloro-3-fluorophenyl, 2-bromo-3-chloro-4-fluorophenyl, 5-bromo-3-chloro- 2-Fluorophenyl, 5-bromo-2-chloro-3-fluorophenyl, 2-bromo-3-chloro-5-fluorophenyl, 5-bromo-4-chloro-3-fluorophenyl, 5-bromo-3 -chloro-4-fluorophenyl, 3-bromo-4-chloro-5-fluoro-phenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoromethylphenyl, 2-trifluoromethylphenyl, 3- Trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 2-fluoro-5-chlorophenyl, 2-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 3-dimethylaminophenyl, 3-fluoro-5 -Trifluoromethylphenyl, 2-chloro-5-trifluoromethylphenyl, 2-chloro-3-trifluoromethylphenyl, 3-chloro-5-trifluoromethylphenyl, 3-fluoro-5-trifluoromethylphenyl These include, but are not limited to:

[0127] In one embodiment of the invention and / or its embodiments, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro Methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2 ,3-Difluororophenyl3,5-difluorophenyl, 2,6-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluoro Phenyl, 3-chloro-5-fluorophenyl, 3-chloro-6-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4-fluor Phenyl, 2-fluoro-3-chlorophenyl, and 2,3,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,6- Difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 3-chloro-5-fluorophenyl, 2-fluoro-3-chlorophenyl, 2 ,3,5-trichlorophenyl, and 3,5-dichloro-4-fluorophenyl, especially 2,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0128] In one embodiment of the invention and / or its embodiments, the compound has the formula (Idi), (Idii), (Idiii), (Idv), (Idvi), (Idvii) or [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 ,R 13 ,R 14 , A1, A2, A3, A4 & R 25 is defined as in any of the embodiments described herein.

[0129] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Idviii) and is preferably in the form of the (S)-enantiomer.

[0130] The present invention is based on R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0131] In one embodiment of the invention and / or its embodiments, R 25 is hydrogen or methyl, more preferably hydrogen.

[0132] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Iei) or (Ieii) [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 ,R 13 ,R 14 , A1, A2, A3, A4 & R 19 is defined as in any of the embodiments described herein.

[0133] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iei) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ieii) and is preferably in the (S)-enantiomeric form.

[0134] The present invention is based on R 1 and R 7 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0135] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl.

[0136] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 -alkyl preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 -alkyl, preferably independently selected from hydrogen, methyl or ethyl.

[0137] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0138] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, hydroxy ethylamino, 2-hydroxyethylmethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of.

[0139] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ifi), (Ifii), (Ifiii), (Ifiv), (Ifv) or (Ifvi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 13 ,R 14 ,A1,A2,A3,A4,R 19 and R 25 is defined as in any of the embodiments described herein.

[0140] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ifvi) and is preferably in the (S)-enantiomeric form.

[0141] The present invention is based on R 1 and R 13 ,R 14 , A1, A2, A3, A4 are defined as follows.

[0142] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atoms to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 1 ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from the group consisting of alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 -Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0143] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0144] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1- 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0145] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Igi), (Igii) (Igiii), (Igiv), (Igv) or (Igvi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0146] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igvi) and is preferably in the (S)-enantiomeric form.

[0147] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atoms to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 1 ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from the group consisting of alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 -alkyl and / or one or more of the ring carbon atoms may be replaced by -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0148] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0149] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0150] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Igvii), (Igiii) (Igix) or (Igx) [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0151] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Igx) and is preferably in the (S)-enantiomeric form.

[0152] The present invention is based on R 1 and R 19 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0153] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl preferably hydrogen and C 1-3 - independently selected from alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0154] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 - optionally substituted with one or more substituents independently selected from the group consisting of alkoxy, halogen, cyano, nitro and hydroxy, each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0155] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro Methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl , 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro -3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro- 4-fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl , 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially independently selected from 2,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0156] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ihi), (Ihii), (Ihiii), (Ihiv), (Ihv) or (Ihvi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 ,R 13 ,R 14 , A1, A2, A3, A4 & R 25 is defined as in any of the embodiments described herein.

[0157] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ihvi) and is preferably in the (S)-enantiomeric form.

[0158] The present invention is based on R 1 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0159] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R6 is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 25 is hydrogen or methyl.

[0160] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 25 is hydrogen or methyl.

[0161] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 25 is hydrogen or methyl, more preferably hydrogen.

[0162] In one embodiment of the invention and / or embodiments thereof, the compound has formula (Iii), (Iiii), (Iiiii) or (Iiiv) [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 ,R 13 ,R 14 , A1, A2, A3, A4 & R 19 is defined as in any of the embodiments described herein.

[0163] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iiiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iiiiv), preferably in the form of the (S)-enantiomer.

[0164] The present invention is based on R 1 provides compounds according to the invention and / or embodiments thereof, wherein is hydrogen.

[0165] The present invention is based on R 7 and R 13 ,R 14 , A1, A2, A3 and A4 are defined as follows.

[0166] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0167] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 -alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 -alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 -alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0168] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -Cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of:

[0169] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0170] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iji), (Ijii), (Ijiii), (Ijiv), (Ijv), (Ijvi), (Ijvi), (Ijviii) or (Ijix) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 19 and R 25 is defined as in any of the embodiments described herein.

[0171] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iji) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijkiii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijiv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijviii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijix) and is preferably in the form of the (S)-enantiomer.

[0172] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0173] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0174] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0175] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0176] In one embodiment of the invention and / or its embodiments, the compound has the formula (Ijx), (Ijxi), (Ijxii), (Ijxiii), (Ijxiv) or (Ijxv) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R19 and R 25 is defined as in any of the embodiments described herein.

[0177] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijx) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijxii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijxiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijxiv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ijxv), preferably in the form of the (S)-enantiomer.

[0178] The present invention is based on R 7 and R 19 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0179] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0180] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of; Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0181] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0182] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro Methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl , 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro -3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro- 4-fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl , 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially independently selected from 2,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0183] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iki), (Ikii), (Ikiii), (Ikiv), (Ikv), (Ikvi), (Ikvii), (klviii) or (Ikix) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 13 R 14 , A1, A2, A3; A4 & R 25 is defined as in any of the embodiments described herein.

[0184] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iki) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikviii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ikix) and is preferably in the form of the (S)-enantiomer.

[0185] The present invention is based on R 7 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0186] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 25 is hydrogen or methyl.

[0187] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having from 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or 3 one further ring atom is selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 -alkyl, preferably selected from hydrogen, methyl or ethyl, R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 25 is hydrogen or methyl.

[0188] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0189] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, Hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3,3-difluoroazetidine -1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1yl independently selected from the group consisting of; R 25 is hydrogen or methyl, more preferably hydrogen.

[0190] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ili), (Ilii), (Iliiii), (Iliv), (Ilv) or (Ilvi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 13 R 14 , A1, A2, A3, A4 & R 19 is defined as in any of the embodiments described herein.

[0191] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ili), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ilii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iliiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iliv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ilv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ilvi) and is preferably in the (S)-enantiomeric form.

[0192] The present invention is based on R 13 ,R 14 , A1, A2, A3 and A4 and R 19 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0193] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0194] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0195] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form 5- or 6-carbon atoms containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O-. It's okay, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0196] In one embodiment of the invention and / or its embodiments, the compound has the formula (Imi), (Imii), (Imiii), (Imiv), (Imv), (Imvi), (Imvii), (Imviii) or (Imix) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 and R 25 is defined as in any of the embodiments described herein.

[0197] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imvii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imviii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imix) and is preferably in the form of the (S)-enantiomer.

[0198] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0199] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N May be replaced with -, -O- or -S- A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0200] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N - or -S- may be substituted, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0201] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Imx), (Imxi), (Imxii), (Imxiii), (Imxiv) or (Imxv) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 and R 25 is defined as in any of the embodiments described herein.

[0202] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imx) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imxi) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imxii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imxiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imxiv) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Imxv) and is preferably in the form of the (S)-enantiomer.

[0203] The present invention is based on R 13 ,R 14 , A1, A2, A3 and A4 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0204] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 25 is hydrogen or methyl.

[0205] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- May be replaced, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl.

[0206] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl, more preferably hydrogen.

[0207] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ini), (Inii), (Iniii), (Iniv), (Inv) or (Invi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 and R 19 is defined as in any of the embodiments described herein.

[0208] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ini) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Inii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iniii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iniv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Inv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Invi) and is preferably in the (S)-enantiomeric form.

[0209] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 25 is hydrogen or methyl.

[0210] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- , -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl.

[0211] In one embodiment of the invention and / or its embodiments, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl, more preferably hydrogen.

[0212] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Invii), (Inviii), (Inix) or (Inx) [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 and R 19 is defined as in any of the embodiments described herein.

[0213] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Invii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Inviii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Inix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Inx) and is preferably in the (S)-enantiomeric form.

[0214] The present invention is based on R 19 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0215] In one embodiment of the invention and / or its embodiments, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl, R 25 is hydrogen or methyl.

[0216] In one embodiment of the invention and / or its embodiments, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -alkoxy may be substituted with one or more halogens, R 25 is hydrogen or methyl.

[0217] In one embodiment of the invention and / or its embodiments, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl; R 25 is hydrogen or methyl, more preferably hydrogen.

[0218] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ioi), (Ioii), (Ioiii), (Ioiv), (Iov) or (Iovi) [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 ,R 7 and R 13 ,R 14 , A1, A2, A3 and A4 are defined as in any of the embodiments described herein.

[0219] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ioi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ioii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ioiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ioiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iov), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iovi), preferably in the form of the (S)-enantiomer.

[0220] The present invention is based on R 1 ,R 7 and R 13 ,R 14 , A1, A2, A3 and A4 are defined as follows.

[0221] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 -or -S may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0222] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0223] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0224] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0225] In one embodiment of the invention and / or its embodiments, the compound has the formula (Ipi), (Ipii), (Ipiii), (Ipiv), (Ipv), (Ipvi), (Ipvii), (Ipviii), (Ipix), (Ipx), (Ipxi) or (Ipxii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 19 and R 25 is defined as in any of the embodiments described herein.

[0226] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipviii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipx) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxii) and is preferably in the form of the (S)-enantiomer.

[0227] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl preferably hydrogen and C 1-3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -Cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -Alkyl.

[0228] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0229] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6-alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0230] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N.

[0231] In one embodiment of the invention and / or its embodiments, the compound has the formula (Ipxiii), (Ipxiv), (Ipxv), (Ipxvi), (Ipxvii), (Ipxviii), (Ipxix) or (Ipxx) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 19 and R 25 is defined as in any of the embodiments described herein.

[0232] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxvii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxviii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxix) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ipxx) and is preferably in the (S)-enantiomeric form.

[0233] The present invention is based on R 1 ,R 7 and R 19 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0234] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atom to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0235] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0236] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0237] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, and 3,3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidine- 1il independently selected from the group consisting of; R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro Methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl , 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro -3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro- 4-fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl , 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially independently selected from 2,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0238] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iqi), (Iqii), (Iqiii), (Iqiv), (Iqv), (Iqvi), (Iqvii) or (Iqviii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 13 ,R 14 , A1, A2, A3, A4 & R 25 is defined as in any of the embodiments described herein.

[0239] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqiv), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqvi), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqvii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iqviii), preferably in the form of the (S)-enantiomer.

[0240] The present invention is based on R 1 ,R 7 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0241] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6-Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles selected from, together with the N atom to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, as well as R 25 is hydrogen or methyl.

[0242] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 25 is hydrogen or methyl.

[0243] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -Cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0244] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 Ile independently selected from the group consisting of; R 25 is hydrogen or methyl, more preferably hydrogen.

[0245] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Iri), (Irii), (Iriii), (Iriv), (Irv), (Irvi), (Irvii) or (Irviii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 13 ,R 14 , A1, A2, A3, A4 & R 19 is defined as in any of the embodiments described herein.

[0246] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iri) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Irii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iriii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iriv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Irv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Irvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Irvii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Irviii) and is preferably in the form of the (S)-enantiomer.

[0247] The present invention is based on R 1 ,R 13 ,R 14 , A1, A2, A3 and A4 are defined as follows.

[0248] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6-Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0249] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from halogen, cyano, hydroxy, preferably each C 1-6-Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0250] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form 5- or 6-carbon atoms containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O-. It's okay, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0251] In one embodiment of the invention and / or its embodiments, the compound has the formula (Isi), (Isii), (Isiii), (Isiv), (Isv), (Isvi), (Isvii), (Isviii), (Isix), (Isx), (Isxi) or (Isxii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 and R 25 is defined as in any of the embodiments described herein.

[0252] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isviii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxii) and is preferably in the (S)-enantiomeric form.

[0253] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from R 4 ,R 5 and R 6 is hydrogen and C 1-6-alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably halogen and C 1-3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 - may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0254] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0255] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N - or -S- may be substituted, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0256] In one embodiment of the invention and / or its embodiments, the compound has the formula (Isxiii), (Ixiv), (Isxv), (Isxvi), (Isxvii), (Isxviii), (Isxix) or (Isxx) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 and R 25 is defined as in any of the embodiments described herein.

[0257] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxiii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxvii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxviii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Isxx) and is preferably in the form of the (S)-enantiomer.

[0258] The present invention is based on R 1 ,R 13 ,R 14 , A1, A2, A3, A4 & R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0259] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atoms to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 1 ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from the group consisting of alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 -Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 25 is hydrogen or methyl.

[0260] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 is N, R 25 is hydrogen or methyl.

[0261] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl, more preferably hydrogen.

[0262] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iti), (Itii), (Itiii), (Itiv), (Itv), (Itvi), (Itvii), (Itviii), (Itix), (Itx), (Itxi) or (Itxii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 and R 19 is defined as in any of the embodiments described herein.

[0263] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iti) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itiii), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itiv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itvi), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itx) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxii) and is preferably in the (S)-enantiomeric form.

[0264] Optionally, in one embodiment of the invention and / or its embodiments: R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atoms to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 1 ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from the group consisting of alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3 -alkyl and / or one or more of the ring carbon atoms may be replaced by -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 25 is hydrogen or methyl.

[0265] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl.

[0266] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N- or may be replaced with -S-, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl, more preferably hydrogen.

[0267] In one embodiment of the invention and / or its embodiments, the compound has the formula (Itxiii), (Itxiiii), (Itxv), (Itxvi), (Itxvii), (Itxviii), (Itxix) or (Itxx) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 and R 19 is defined as in any of the embodiments described herein.

[0268] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxiv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxv), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxvi), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxvii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Itxx), preferably in the form of the (S)-enantiomer.

[0269] The present invention is based on R 1 ,R 19 and R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0270] R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy, NR 2 R 3 ,C(=O)OR 4 and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1-6 -alkyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2’ R 3’ optionally substituted with one or more substituents independently selected from the group consisting of; R 2 and R 3 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 2 and R 3 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms of are selected from N, S and O; Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl or 5-10 membered heteroaryl or R 2 and R 3 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 1-6 -alkoxy optionally substituted with one or more substituents independently selected from the group consisting of; R 4 ,R 5 and R 6 is hydrogen and C 1-6 -alkyl, preferably hydrogen and C 1-3 - independently selected from alkyl, R 2’ and R 3’ is hydrogen and C 1-6 -alkyl preferably hydrogen and C 1-3 - independently selected from alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’は、 Hydrogen and C 1-6 - independently selected from alkyl, R 25 is hydrogen or methyl.

[0271] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and C(=O)NR 5 R 6 independently selected from the group consisting of; Each C 1 - 6 -alkyl or C 1 - 6 -Alkoxy is C 1 - 6 -Alkyl, C 1 - 6 -Alkoxy, halogen, cyano, nitro, hydroxy and NR 2 'R 3 ’ optionally substituted with one or more substituents independently selected from the group consisting of; R 5 and R 6 is hydrogen and C 1 - 3 - independently selected from alkyl, R 2 ’ and R 3 ’ is hydrogen and C 1 - 3 - independently selected from alkyl, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -alkoxy may be substituted with one or more halogens, R 25 is hydrogen or methyl.

[0272] In one embodiment of the invention and / or its embodiments, R 1 teeth, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride independently selected from the group consisting of; R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro Methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl , 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro -3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro- 4-fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl , 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially independently selected from 2,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl; R 25 is hydrogen or methyl, more preferably hydrogen.

[0273] In one embodiment of the invention and / or its embodiments, the compound has the formula (Iui), (Iuii), (Iuiii), (Iuiv), (Iuv), (Iuvi), (Iuvii), (Iuviii), (Iuix), (Iux), (Iuxi) or (Iuxii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 7 and R 13 ,R 14 , A1, A2, A3, and A4 are defined as in any of the embodiments described herein.

[0274] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iui), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuiv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuv) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuvii) and is preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iux) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iuxii) and is preferably in the (S)-enantiomeric form.

[0275] The present invention is based on R 7 ,R 13 ,R 14, A1, A2, A3 and A4 are defined as follows.

[0276] Optionally, in one embodiment of the invention and / or its embodiments: R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, and 0, 1, 2, or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0277] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of; Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0278] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0279] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form 5- or 6-carbon atoms containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O-. It's okay, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0280] In one embodiment of the invention and / or its embodiments, the compound has the formula (Ivi), (Ivii), (Iviii), (Iviv), (Ivv), (Ivvi), (Ivvii), (Ivviii), (Ivix), (Ivx), (Ivxi) or (Ivxii) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 and R 25 is defined as in any of the embodiments described herein.

[0281] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivi), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Iviv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivv), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivvi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivviii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivix) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivx), preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxi) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxii), preferably in the form of the (S)-enantiomer.

[0282] Optionally, in one embodiment of the invention and / or its embodiments: R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 ,S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ , and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N, 0, 1, 2, or the three further ring atoms are selected from N, S and O, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10- Aryl, 5-10 membered heterocyclyl, or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)-OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, an unsaturated ring containing one or more C 1-3- may be substituted with alkyl and / or one or more of the ring-forming carbon atoms may be replaced with -NH-, -N=, =N-, -O- or -S-, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 19 teeth, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of; Each C 6-10 -Aryl or 5-10 membered heteroaryl is C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, nitro, hydroxy, NR 20 R 21 ,C(=O)OR 22 and C(=O)NR 23 R 24 optionally substituted with one or more substituents independently selected from the group consisting of; R 20 and R 21 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl and C 6-10 -Aryl independently selected from the group consisting of, or R 20 and R 21 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, 0, 1, 2 or 3 further ring atoms are N , S and O, Each C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, or C 6-10 -aryl or R 20 and R 21 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 1-6 -alkoxy, 5-10 membered heterocyclyl, C 6-10 -Aryl, 5-10 membered heteroaryl, halogen, cyano, hydroxy, NR 20’ R 21’ ,C(=O)OR 22’ and C(=O)NR 23’ R 24’ optionally substituted with one or more substituents independently selected from the group consisting of; R 22 ,R 23 and R 24 is hydrogen and C 1-6 - independently selected from alkyl, R 20’ ,R 21’ ,R 22’ ,R 23’ and R 24’ is hydrogen and C 1-6 - independently selected from alkyl.

[0283] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle with 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N -, -O- or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 -3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is a 5-10 membered heteroaryl, 5-10 membered heteroaryl is C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, nitro and hydroxy optionally substituted with one or more substituents independently selected from the group consisting of; Each C 1-6 -Alkyl, C 1-6 -Alkoxy may be substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, preferably each C 1-6 -Alkyl, C 1-6 -Alkoxy may be optionally substituted with one or more halogens.

[0284] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0285] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing an unsaturated ring, one or more of the ring-forming carbon atoms being -NH-, -N=, =N - or -S- may be substituted, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 19 is 3,5-dichlorophenyl, 2,3-dichlorophenyl, 2,3,5-trifluorophenyl, 3-trifluoromethylphenyl, 3-methoxyphenyl, 2,3-dimethylphenyl, 3-chlorophenyl, 3-trifluorophenyl Fluoromethoxyphenyl, 3-dimethylaminophenyl, 3,5-difluorophenyl, 2,3-difluorophenyl, 3,4,5-trifluorophenyl, 2-fluoro-3-chlorophenyl, 2-fluoro-5-trifluoro methylphenyl, naphth-1-yl, 2-fluoro-5-chlorophenyl, 3-fluoro-5-trifluoromethylphenyl, and 2,3,5-trichlorophenyl, preferably 3-fluororophenyl, 3-chlorophenyl, 2,3-difluorophenyl 3,5-difluorophenyl, 2,3-di-chlorophenyl, 3,5-dichlorophenyl, 2-chloro-3-fluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro- 3-fluorophenyl, 3-chloro-5-fluorophenyl, 5-chloro-2-fluorophenyl, 3,4,5-trifluorophenyl, 2,3,5-trifluorophenyl, 3,5-dichloro-4 -fluorophenyl and 3,4,5-trichlorophenyl, more preferably 3-chlorophenyl, 2,3-dichlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 2,3,5-trifluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-2-fluorophenyl, 5-chloro-3-fluorophenyl, 5-chloro-3-fluorophenyl, 3,5-dichloro-4-fluorophenyl, especially 2 ,3,5-trifluorophenyl, 2,3-dichlorophenyl and 3,5-dichlorophenyl.

[0286] In one embodiment of the invention and / or embodiments thereof, the compound has the formula (Ivxiii), (Ivxiv), (Ivxv), (Ivxvi), (Ivxvii), (Ivxviii), (Ivxix) or (Ivxx) [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] or in its stereoisomers, physiologically acceptable salts, esters, solvates, polymorphs, prodrugs and mixtures, in which R 1 and R 25 is defined as in any of the embodiments described herein.

[0287] In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxiii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxiv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxv), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxvi), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxvii) and is preferably in the (S)-enantiomeric form. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxviii), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxix), preferably in the form of the (S)-enantiomer. In one embodiment of the invention and / or its embodiments, the compound is according to formula (Ivxx) and is preferably in the (S)-enantiomeric form.

[0288] The present invention is based on R 7 ,R 13 ,R 14 , A1, A2, A3, A4 & R 25 We provide compounds according to the invention and / or embodiments thereof, in which: is defined as follows.

[0289] Optionally, in one embodiment of the invention and / or its embodiments: R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8 R 9 ,C(=O)OR 10 , S.R. 10 ,SOR 10 , S.O. 2 R 10 and C(=O)NR 11 R 12 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, C 3-10 -cycloalkyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 3-10 -cycloalkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -Aryl, 5-10 membered heterocyclyl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5-10 membered heterocyclyl or 5-10 membered heteroaryl or R 8 and R 9 The heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, NR 8’’ R 9’’ ,C(=O)OR 10’’ and C(=O)NR 11’’ R 12’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 ,R 11 and R 12 is hydrogen and C 1-6 - independently selected from alkyl, R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen and C 1-6 - independently selected from alkyl, R 8’’ ,R 9’’ ,R 10’’ ,R 11’’ and R 12’’ is hydrogen and C 1-6 - independently selected from alkyl, R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, a saturated ring containing one or more C 1-3 Optionally substituted with -alkyl or =O and / or one or more of the ring-forming carbon atoms is -NH-, -O-, -S(O)-, -S(O) 2 - or -S- may be substituted, A1 is N or CR 15 and R 15 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 15’ R 15’’ and R 15’ and R 15’’ is independently C 1-3 -alkyl, A2 is N or CR 16 and R 16 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 16’ R 16’’ and R 16’ and R 16’’ is independently C 1-3 -alkyl, A3 is N or CR 17 and R 17 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 17’ R 17’’ and R 17’ and R 17’’ is independently C 1-3 -alkyl, A4 is N or CR 18 and R 18 are independently hydrogen, halogen, C 1 - 3 Alkyl, C 1 - 3 Alkoxy or NR 18’ R 18’’ and R 18’ and R 18’’ is independently C 1-3 -alkyl, R 25 is hydrogen or methyl.

[0290] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-3 -Alkoxy, hydroxy, NR 8 R 9 , S.R. 10 ,SOR 10 and S.O. 2 R 10 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-3 -Alkoxy is C 1-3 -Alkyl, 5-10 membered heterocyclyl, C 1-6 -Alkoxy, halogen, cyano, hydroxy, oxo, NR 8’ R 9’ ,C(=O)OR 10’ and C(=O)NR 11’ R 12’ optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl, C 6-10 -Aryl and 5-10 membered heteroaryl independently selected from the group consisting of, or R 8 and R 9 together with the N atom to which they are attached form a saturated or unsaturated heterocycle having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or three further ring atoms are selected from N, S and O; C 1-6 -Alkyl, C 6-10 -aryl or 5-10 membered heteroaryl or R 8 and R 9 Heteroheterocycles formed from, together with the N atoms to which they are attached, C 1-6 -Alkyl, C 1-6 -Alkoxy, hydroxy and NR 8’’ R 9’’ optionally substituted with one or more substituents independently selected from the group consisting of; R 10 is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’ ,R 9’ ,R 10’ ,R 11’ and R 12’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 8’’ and R 9’’ is hydrogen or C 1-3 - alkyl, preferably independently selected from hydrogen, methyl or ethyl; R 13 and R 14together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being -NH-, -O- or -S- may be replaced with A1 is N or CR 15 and R 15 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 are independently hydrogen, C 1 - 3 Alkyl or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl.

[0291] In one embodiment of the invention and / or its embodiments, R 7 teeth, Hydrogen, C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl, C 1-6 -Alkoxy, NR 8 R 9 independently selected from the group consisting of; Each C 1-6 -Alkyl, C 2 - 6 -alkenyl, 4-10 membered heterocyclyl or C 1-6 -Alkoxy is C 1-6 -Alkyl, C 1-6 -alkoxy and halogen optionally substituted with one or more substituents independently selected from the group consisting of; R 8 and R 9 teeth, Hydrogen, C 1-6 -Alkyl, C 3-6 -cycloalkyl independently selected from the group consisting of; C 1-6 -alkyl, or C 3-6 -cycloalkyl is C 1-6 -Alkyl, C 1-6 -alkoxy and hydroxy may be substituted with one or more substituents independently selected from the group consisting of

[0292] Appropriately, R 7 teeth, Methyl, ethyl, isopropyl, isopropenyl, methoxy, ethoxy, isopropoxy, hydroxy, methylsulfoxyl, methylsulfonyl, methylthio, amino, methylamino, ethylamino, isopropylamino, dimethylamino, isopropylmethylamino, cyclopropylamino, 2 -Hydroxyethylmethylamino, hydroxyethylamino, methoxyethylamino, morpholin-4-yl, 4-methylpiperazin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 3-fluoroazetidin-1-yl, 3 , 3-difluoroazetidin-1-yl, 4-oxo-1-piperidyl, azetidin-1-yl, tetrahydro-2H-pyran-4-yl, piperidin-1-yl, and 4,4-difluoropiperidin-1 IL independently selected from the group consisting of; R 13 and R 14 together with the atoms to which they are attached form a 5- or 6-carbon atom containing a saturated ring, one or more of the ring-forming carbon atoms being replaced by -NH- or -O- Good too, A1 is N or CR 15 and R 15 is independently hydrogen or C 1 - 3 is alkoxy, A2 is N or CR 16 and R 16 is independently hydrogen or C 1 - 3 is alkoxy, A3 is N or CR 17 and R 17 is independently hydrogen or C 1 - 3 is alkoxy, A4 is N or CR 18 and R 18 is independently hydrogen or C 1 - 3 is alkoxy, 0, 1 or 2 of A1, A2, A3 and A4 are N, R 25 is hydrogen or methyl, more preferably hydrogen.

[0293] In one embodiment of the invention and / or i...

Claims

1. A compound of formula (I) 【Chemistry 1】 During the ceremony, R １ teeth, Hydrogen, C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１ ０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, C １－６ -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR ２ R ３ , COOH, C(=O)OR ４ , S.R. ４ , SOR ４ , S.O. ２ R ４ , S.O. ２ NR ５ R ６ and C(=O)NR ５ R ６ are independently selected from the group consisting of Each C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ - Cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy and C １－６ -Alkylmercapto is C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, C １－６ -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR ２’ R ３’ , C(=O)OR ４’ , S.R. ４’ , SOR ４’ , S.O. ２ R ４’ , S.O. ２ NR ５’ R ６’ and C(=O)NR ５’ R ６’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２ and R ３ teeth, Hydrogen, C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy-C １ - ６－ Alkyl, C ３－１０ -C substituted with cycloalkyl １ - ６ -C substituted with alkyl, 5- to 10-membered heterocyclyl １ - ６ -Alkyl, C ６－１０ -aryl-substituted C １ - ６ -C substituted with alkyl and 5-10 membered heteroaryl １ - ６ -Alkyl or independently selected from the group consisting of R ２ and R ３ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, in which 0, 1, 2, or 3 further ring atoms are selected from N, S, and O; Each C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy-C １ - ６－ Alkyl, C ３－１０ -C substituted with cycloalkyl １ - ６ -C substituted with alkyl, 5- to 10-membered heterocyclyl １ - ６ -Alkyl, C ６－１０ -aryl-substituted C １ - ６ -C substituted with alkyl and 5-10 membered heteroaryl １ - ６ The heteroheterocycle formed by alkyl and R 2 and R 3 together with the N atom to which they are attached is C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, halogen, cyano, hydroxy, mercapto, NR ２’’ R ３’’ , C(=O)OR ４’’ , S.R. ４’’ , SOR ４ , S.O. ２ R ４’’ , S.O. ２ NR ５’’ R ６’’ and C(=O)NR ５’’ R ６’’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ４ , R ５ and R ６ is hydrogen and C １－６ -alkyl; R ２’ , R ３’ , R ４’ , R ５’ and R ６’ is hydrogen and C １－６ -alkyl; R ２’’ , R ３’’ , R ４’’ , R ５’’ and R ６’’ is hydrogen and C １－６ -alkyl; R ７ teeth, Hydrogen, C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 4- to 10-membered heterocyclyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, C １－６ -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR ８ R ９ , COOH, C(=O)OR １０ , S.R. １０ , SOR １０ , S.O. ２ R １０ , S.O. ２ NR １１ R １２ and C(=O)NR １１ R １２ are independently selected from the group consisting of Each C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 4- to 10-membered heterocyclyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy and C １－６ -Alkylmercapto is C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, C １－６ -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, oxo, NR ８’ R ９’ , C(=O)OR １０’ , S.R. １０’ , SOR １０’ , S.O. ２ R １０’ , S.O. ２ NR １１’ R １２’ and C(=O)NR １１’ R １２’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ８ and R ９ teeth, Hydrogen, C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy-C １ - ６－ Alkyl, C ３－１０ -C substituted with cycloalkyl １ - ６ -C substituted with alkyl, 5- to 10-membered heterocyclyl １ - ６ -Alkyl, C ６－１０ -aryl-substituted C １ - ６ -C substituted with alkyl and 5-10 membered heteroaryl １ - ６ -Alkyl or independently selected from the group consisting of R ８ and R ９ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, in which 0, 1, 2, or 3 further ring atoms are selected from N, S, and O; Each C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy-C １ - ６－ Alkyl, C ３－１０ -C substituted with cycloalkyl １ - ６ -C substituted with alkyl, 5- to 10-membered heterocyclyl １ - ６ -Alkyl, C ６－１０ -aryl-substituted C １ - ６ -C substituted with alkyl and 5-10 membered heteroaryl １ - ６ The heteroheterocycle formed by alkyl and R 8 and R 9 together with the N atom to which they are attached is C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, halogen, cyano, hydroxy, mercapto, NR ８’’ R ９’’ , C(=O)OR １０’’ , S.R. １０’’ , SOR １０’’ , S.O. ２ R １０’’ , S.O. ２ NR １１’’ R １２’’ and C(=O)NR １１’’ R １２’’ and optionally substituted with one or more substituents independently selected from the group consisting of: R １０ , R １１ and R １２ is hydrogen and C １－６ -alkyl; R ８’ , R ９’ , R １０’ , R １１’ and R １２’ is hydrogen and C １－６ -alkyl; R ８’’ , R ９’’ , R １０’’ , R １１’’ and R １２’’ is hydrogen and C １－６ -alkyl; R １３ is hydrogen or C １ - ３ is alkyl, R １４ is hydrogen, C １ - ３ Alkyl, C １ - ３ Alkoxy, NR １４’ R １４’’ and R １４’ and R １４’’ is independent, C １－３ - alkyl, or R 13 and R 14 together with the atoms to which they are attached form a ring containing 5 or 6 carbon atoms that is saturated except for the bond between the carbon atoms shared by the adjacent rings, and the ring contains one or more C １－３ and / or one or more of the ring-forming carbon atoms may be substituted with -alkyl or ═O, and / or one or more of the ring-forming carbon atoms may be substituted with -NH-, -O-, -S(O)-, -S(O) ２ may be replaced by - or -S-, or R １３ and R １４ together with the atoms to which they are attached form an unsaturated ring containing 5 or 6 carbon atoms, and the unsaturated ring may contain one or more C １－３ -alkyl and / or one or more of the ring-forming carbon atoms may be replaced by -NH-, -N=, -N-, -O- or -S-; A1 is N or CR １５ and R １５ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １５’ R １５’’ and R １５’ and R １５’’ teeth Independently, C １－３ - alkyl, A2 is N or CR １６ and R １６ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １６’ R １６’’ and R １６’ and R １６’’ teeth Independently, C １－３ - alkyl, A3 is N or CR １７ and R １７ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １７’ R １７’’ and R １７’ and R １７’’ teeth Independently, C １－３ - alkyl, A4 is N or CR １８ and R １８ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １８’ R １８’’ and R １８’ and R １８’’ is independent, C １－３ - alkyl, R １９ is C ６－１０ - independently selected from the group consisting of aryl and 5- to 10-membered heteroaryl; Each C ６－１０ -aryl and 5- to 10-membered heteroaryl are C １－６ -Alkyl, C ２－６ -alkenyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, C １－６ -Alkylmercapto, halogen, cyano, nitro, hydroxy, mercapto, NR ２０ R ２１ , C(=O)OR ２２ , S.R. ２２ , SOR ２２ , S.O. ２ R ２２ , S.O. ２ NR ２３ R ２４ and C(=O)NR ２３ R ２４ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２０ and R ２１ teeth, Hydrogen, C １－６ -Alkyl, C ３－１０ -cycloalkyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy-C １ - ６－ Alkyl, C ６－１０ -aryl-substituted C １ -C ６ -C substituted with alkyl, 5-10 membered heteroaryl １ - ６ -Alkyl or independently selected from the group consisting of R ２０ and R ２１ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, in which 0, 1, 2, or 3 further ring atoms are selected from N, S, and O; Each C １－６ -alkyl, C 3-10 -cycloalkyl, C 6-10 -aryl, 5- to 10-membered heteroaryl and the heteroheterocycle formed by R 20 and R 21 together with the N atom to which they are attached are C １－６ -Alkyl, C ２－６ -alkenyl, C ２－６ -alkynyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, halogen, cyano, hydroxy, mercapto, NR ２０’ R ２１’ , C(=O)OR ２２’ , S.R. ２２’ , SOR ２２’ , S.O. ２ R ２２’ , S.O. ２ NR ２３’ R ２４’ , and C(═O)NR ２３’ R ２４’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２２ , R ２３ and R ２４ is hydrogen and C １－６ -alkyl; R ２０’ , R ２１’ , R ２２’ , R ２３’ and R ２４’ is hydrogen and C １－６ -alkyl; R ２５ is hydrogen and C １－６ - independently selected from alkyl, A compound of formula (I), or a stereoisomer, physiologically acceptable salt, solvate or mixture thereof.

2. R １ but, Hydrogen, C １－６ -Alkyl, C １－６ -alkoxy, halogen, cyano, nitro, hydroxy, NR ２ R ３ , C(=O)OR ４ and C(=O)NR ５ R ６ are independently selected from the group consisting of Each C １－６ -Alkyl and C １－６ -alkoxy is C １－６ -Alkyl, C １－６ -alkoxy, halogen, cyano, nitro, hydroxy and NR ２’ R ３’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２ and R ３ but, Hydrogen, C １－６ -Alkyl, C ３－１０ -cycloalkyl, C ６－１０－ Aryl and 5- to 10-membered heteroaryl or independently selected from the group consisting of R ２ and R ３ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, in which one ring atom is N and 0, 1, 2 or 3 further ring atoms are selected from N, S and O; Each C １－６ -Alkyl, C ３－１０ -cycloalkyl, C ６－１０－ Aryl and 5- to 10-membered heteroaryl and the heteroheterocycle formed by R 2 and R 3 taken together with the N atom to which they are attached are C １－６ -Alkyl, C ３－１０ -cycloalkyl and C １－６ -alkoxy and optionally substituted with one or more substituents independently selected from the group consisting of: R ４ , R ５ and R ６ is hydrogen and C １－６ -alkyl; R ２’ and R ３’ is hydrogen and C １－６ - independently selected from alkyl, The compound of claim 1.

3. R １ but, Hydrogen, C １－６ -Alkyl, C １－６ -alkoxy and halogen are independently selected from the group consisting of Each C １－６ -Alkyl and C １－６ -alkoxy is C １－６ -Alkyl, C １－６ -alkoxy, halogen, cyano, hydroxy and NR ２’ R ３’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２’ and R ３ ' is hydrogen and C １－３ - independently selected from alkyl, 3. The compound according to claim 1 or 2.

4. R １ but, Hydrogen, methyl, trifluoromethyl, ethyl, methoxy, ethoxy, fluoride and chloride Independently selected from the group consisting of: The compound according to any one of claims 1 to 3.

5. R ７ but, Hydrogen, C １－６ -Alkyl, C ２ - ６ -alkenyl, C ３－１０ -cycloalkyl, 4 10-membered heterocyclyl, C １－６ -alkoxy, halogen, cyano, hydroxy, NR ８ R ９ , C(=O)OR １０ , S.R. １０ , SOR １０ , S.O. ２ R １０ and C(=O)NR １１ R １２ are independently selected from the group consisting of Each C １－６ -Alkyl, C ２ - ６ -alkenyl, C ３－１０ -cycloalkyl, 4- to 10-membered heterocyclyl and C １－６ -alkoxy is C １－６ -Alkyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C １－６ -alkoxy, halogen, cyano, hydroxy, oxo, NR ８’ R ９’ , C(=O)OR １０’ , and C(═O)NR １１’ R １２’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ８ and R ９ but, Hydrogen, C １－６ -Alkyl, C ３－１０ -cycloalkyl, C ６－１０ -aryl, 5- to 10-membered heterocyclyl and 5- to 10-membered heteroaryl or independently selected from the group consisting of R ８ and R ９ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2 or 3 further ring atoms being selected from N, S and O; Each C １－６ -Alkyl, C ３－１０ -cycloalkyl, C ６－１０－ Aryl, 5- to 10-membered heterocyclyl, and 5- to 10-membered heteroaryl, as well as the heteroheterocycle formed by R 8 and R 9 taken together with the N atom to which they are attached, are C １－６ -Alkyl, C １－６ -alkoxy, halogen, cyano, hydroxy, NR ８’’ R ９’’ , C(═O)—OR １０’’ and C(=O)NR １１’’ R １２’’ and optionally substituted with one or more substituents independently selected from the group consisting of: R １０ , R １１ and R １２ is hydrogen and C １－６ -alkyl; R ８’ , R ９’ , R １０’ , R １１’ and R １２’ is hydrogen and C １－６ -alkyl; R ８’’ , R ９’’ , R １０’’ , R １１’’ and R １２’’ is hydrogen and C １－６ - independently selected from alkyl, The compound according to any one of claims 1 to 4.

6. R ７ but, Hydrogen, C １－６ -Alkyl, C ２ - ６ -alkenyl, 4- to 10-membered heterocyclyl, C １－６ -alkoxy, hydroxy, NR ８ R ９ , C(=O)OR １０ , S.R. １０ , SOR １０ , S.O. ２ R １０ and C(=O)NR １１ R １２ are independently selected from the group consisting of Each C １－６ -Alkyl, C ２ - ６ -alkenyl, 4- to 10-membered heterocyclyl and C １－６ -alkoxy is C １－６ -alkyl, 5- to 10-membered heterocyclyl, C １－６ -alkoxy, halogen, cyano, hydroxy, oxo, NR ８’ R ９’ , C(=O)OR １０’ and C(=O)NR １１’ R １２’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ８ and R ９ but, Hydrogen, C １－６ -Alkyl, C ３－６ -cycloalkyl, C ６－１０ -aryl and 5- to 10-membered heteroaryl or independently selected from the group consisting of R ８ and R ９ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, one ring atom being N and 0, 1, 2, or 3 further ring atoms being selected from N, S, and O; C １－６ -Alkyl, C ６－１０ aryl, and 5- to 10-membered heteroaryl and the heteroheterocycle formed by R 8 and R 9 together with the N atom to which they are attached are C １－６ -Alkyl, C １－６ -alkoxy, hydroxy and NR ８’’ R ９’’ and optionally substituted with one or more substituents independently selected from the group consisting of: R １０ , R １１ and R １２ is hydrogen or C １－６ -alkyl; R ８’ , R ９’ , R １０’ , R １１’ and R １２’ is hydrogen or C １－６ -alkyl; R ８’’ and R ９’’ is hydrogen or C １－６ - independently selected from alkyl, The compound according to any one of claims 1 to 5.

7. R ７ but, Hydrogen, C １－６ -Alkyl, C ２ - ６ -alkenyl, 4- to 10-membered heterocyclyl, C １－６ -alkoxy, NR ８ R ９ are independently selected from the group consisting of Each C １－６ -Alkyl, C ２ - ６ -alkenyl, 4- to 10-membered heterocyclyl and C １－６ -alkoxy is C １－６ -Alkyl, C １－６ -alkoxy and halogen and optionally substituted with one or more substituents independently selected from the group consisting of: R ８ and R ９ but, Hydrogen, C １－６ -Alkyl, C ３－６ -cycloalkyl are independently selected from the group consisting of Said C １－６ - alkyl, or C ３－６ -cycloalkyl is C １－６ -Alkyl, C １－６ -alkoxy and hydroxy and optionally substituted with one or more substituents independently selected from the group consisting of: The compound according to any one of claims 1 to 6.

8. R １３ and R １４ together with the atoms to which they are attached form a ring containing 5 or 6 carbon atoms that is saturated except for bonds between carbon atoms shared by adjacent rings, and this ring contains one or more C １－３ and / or one or more of the ring-forming carbon atoms may be substituted with -alkyl or ═O, and / or one or more of the ring-forming carbon atoms may be substituted with -NH-, -O-, -S(O)-, -S(O) ２ may be replaced by - or -S-, or R １３ and R １４ together with the atoms to which they are attached form an unsaturated ring containing 5 or 6 carbon atoms, said unsaturated ring containing one or more C １－３ -alkyl, and / or one or more of the ring-forming carbon atoms may be replaced by -NH-, -N=, ═N-, -O-, or -S-; A1 is N or CR １５ and R １５ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １５’ R １５’’ and R １５’ and R １５’’ is independent, C １－３ - alkyl, A2 is N or CR １６ and R １６ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １６’ R １６’’ and R １６’ and R １６’’ is independently C １－３ - alkyl, A3 is N or CR １７ and R １７ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １７’ R １７’’ and R １７’ and R １７’’ is independent, C １－３ - alkyl, A4 is N or CR １８ and R １８ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １８’ R １８’’ and R １８’ and R １８’’ is independent, C １－３ - is alkyl, The compound according to any one of claims 1 to 7.

9. R １３ and R １４ together with the atoms to which they are attached form a ring containing 5 or 6 carbon atoms that is saturated except for bonds between carbon atoms shared by adjacent rings, one or more of said ring-forming carbon atoms being optionally replaced by -NH-, -O- or -S-; or R １３ and R １４ together with the atoms to which they are attached form an unsaturated ring containing 5 or 6 carbon atoms, one or more of the ring-forming carbon atoms being optionally replaced by -NH-, -N=, =N-, -O- or -S-; A1 is CR １５ and R １５ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １５’ R １５’’ and R １５’ and R １５’’ is independent, C １－３ - alkyl, A2 is CR １６ and R １６ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １６’ R １６’’ and R １６’ and R １６’’ is independent, C １－３ - alkyl, A3 is CR １７ and R １７ is hydrogen, A4 is CR １８ and R １８ is hydrogen, The compound according to any one of claims 1 to 8.

10. R １３ and R １４ together with the atoms to which they are attached form a ring containing 5 or 6 carbon atoms which is saturated except for the bond between the carbon atoms shared by the adjacent rings, and one or more of said ring-forming carbon atoms is optionally replaced by -NH-, -O- or -S-; A1 is CR １５ and R １５ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １５’ R １５’’ and R １５’ and R １５’’ is independent, C １－３ - alkyl, A2 is CR １６ and R １６ are independently hydrogen, halogen, C １ - ３ Alkyl, C １ - ３ Alkoxy or NR １６’ R １６’’ and R １６’ and R １６’’ is independent, C １－３ - alkyl, A3 is CR １７ and R １７ is hydrogen, A4 is CR １８ and R １８ is hydrogen, The compound according to any one of claims 1 to 9.

11. The compound according to any one of claims 1 to 10, wherein 0, 1 or 2 of residues A1, A2, A3 and A4 are N.

12. R 19 is C ６－１０ -aryl and 5- to 10-membered heteroaryl are independently selected from the group consisting of Each C ６－１０ aryl and 5- to 10-membered heteroaryl are C １－６ -Alkyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, halogen, cyano, nitro, hydroxy, NR ２０ R ２１ , C(=O)OR ２２ and C(=O)NR ２３ R ２４ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２０ and R ２１ but, Hydrogen, C １－６ -Alkyl, C ３－１０ -cycloalkyl and C ６－１０ -aryl or independently selected from the group consisting of R ２０ and R ２１ together with the N atom to which they are attached form a saturated or unsaturated heterocyclic ring having 3 to 12 ring atoms, in which 0, 1, 2, or 3 further ring atoms are selected from N, S, and O; Each C １－６ -Alkyl, C ３－１０ -cycloalkyl, and C 6-10 -aryl and the heteroheterocycle formed by R 20 and R 21 together with the N atom to which they are attached are C １－６ -Alkyl, C ３－１０ -cycloalkyl, 5- to 10-membered heterocyclyl, C ６－１０ -aryl, 5- to 10-membered heteroaryl, C １－６ -alkoxy, halogen, cyano, hydroxy, NR ２０’ R ２１’ , C(=O)OR ２２’ and C(=O)NR ２３’ R ２４’ and optionally substituted with one or more substituents independently selected from the group consisting of: R ２２ , R ２３ and R ２４ are independently hydrogen and C １－６ - alkyl, R ２０’ , R ２１’ , R ２２’ , R ２３’ and R ２４’ is hydrogen and C １－６ - independently selected from alkyl, The compound according to any one of claims 1 to 11.

13. R １９ but, C ６－１０ -aryl and 5- to 10-membered heteroaryl are independently selected from the group consisting of Each C ６－１０ aryl and 5- to 10-membered heteroaryl are C １－６ -Alkyl, C １－６ -alkoxy, halogen, cyano, nitro and hydroxy and optionally substituted with one or more substituents independently selected from the group consisting of: The compound according to any one of claims 1 to 12.

14. R １９ is C ６－１０ -aryl, Said C ６－１０ -aryl is C １－６ -alkyl, halogen, C 1-6 -alkoxy, cyano and nitro and optionally substituted with one or more substituents independently selected from the group consisting of: A compound according to any one of claims 1 to 13.

15. R ２５ The compound of any one of claims 1 to 14, wherein is hydrogen.

16. Formula (I) 【change】 1. A method for preparing a compound according to claim 1, To obtain a compound according to formula (I), a compound of formula (A) 【Chemistry 2】 with a compound of formula (B) 【Transformation 3】 and reacting the compound with In the formula, R １ , R ７ , R １３ , R １４ , A1, A2, A3, A4, R １９ and R ２５ but, As defined in any one of claims 1 to 15 A method for preparing a compound according to formula (I).

17. a compound according to formula (I) according to any one of claims 1 to 15, - one or more physiologically acceptable excipients; 10. A veterinary composition comprising:

18. 18. A veterinary composition according to claim 17 for use as a pharmaceutical.

19. 18. A veterinary composition according to claim 17 for use in the treatment of disorders / diseases caused by helminths.

20. 20. The veterinary composition of claim 17, for use as claimed in claim 19, wherein the disease is canine heartworm disease.

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