Manufacturing method of powder-encapsulated container

Abstract

To provide a method for manufacturing a powder-encapsulated container, which can accurately determine the presence of foreign matter in powder in a transparent container and has a low defective product rate.SOLUTION: A manufacturing method of powder-encapsulated container includes: an encapsulation step of encapsulating powder 21 in a vial 20; an inspection step to inspect foreign matter in the powder 21; and a defective product sorting step in which the vial 20 determined to contain foreign matter is regarded as a defective product. In the inspection step, while the vial 20 is vibrated via a clamp 12 that supports the vial 20, the clamp 12 is reciprocally vibrated in a vertical direction 5 and a horizontal direction 7 to allow the powder 21 in the vial 20 to flow and the flowing powder 21 is optically photographed through the vial 20, and it is determined whether or not foreign matter is present in the powder 21 based on the photographed image.SELECTED DRAWING: Figure 2

Description

[Technical field]

[0001] The present invention relates to a foreign matter inspection method for inspecting whether or not foreign matter is present in powder contained in a transparent container, and a method for manufacturing a powder-sealed container. [Background technology]

[0002] Conventionally, powder medicines such as injections, powders, fine granules, and granules are packaged in transparent containers such as vials. Known methods for inspecting whether foreign objects are present in the powder in the transparent container include visual inspection and inspection by analyzing optically obtained image data (Patent Document 1). The foreign object detection method described in Patent Document 1 applies a composite vibration in the vertical and horizontal directions to a transparent container filled with powder, and optically detects foreign objects in the powder. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 5307459 Summary of the Invention [Problem to be solved by the invention]

[0004] However, powder with poor fluidity does not disperse and flow due to the composite vibration, but flows as clumps, so foreign matter contained in the flowing powder does not appear on the surface of the powder clumps, resulting in a problem of poor detection rate for foreign matter. As a result, there is a risk that the powder may be judged to be a non-defective product with no foreign matter present, even though foreign matter is actually present in the powder.

[0005] The present invention has been made in consideration of the above-mentioned circumstances, and its object is to provide a manufacturing method for a powder-filled container that can accurately determine the presence of foreign matter in the powder inside a transparent container and has a low defect rate. [Means for solving the problem]

[0006] (1) A method for manufacturing a powder-filled container according to the present invention includes a filling step of filling a transparent container with powder, an inspection step of inspecting the powder for foreign matter, and a defective product selection step of classifying the transparent container in which a foreign matter is determined to be present as a defective product. The inspection step includes applying vibrations to the transparent container via a support part that supports the transparent container, while applying reciprocating vibrations to the support part in a first direction and in a second direction intersecting the first direction to cause the powder in the transparent container to flow, optically photographing the flowing powder through the transparent container, and determining whether or not a foreign matter is present in the powder based on the photographed image.

[0007] In the inspection process, the vibration applied via the support part breaks up powder lumps in the transparent container, making the powder more likely to scatter. The reciprocating vibration in the first direction and the reciprocating vibration in the second direction cause the powder to flow so as to circulate in the transparent container. As a result, the powder flows while scattering in the transparent container, so that foreign matter in the powder is more likely to be exposed in the inspection process and the foreign matter is more likely to appear in the captured image. Then, in the defective product selection process, transparent containers determined to contain foreign matter are deemed defective, so the foreign matter contamination rate of the manufactured powder-filled containers is low.

[0008] (2) Preferably, the transparent container has a container body having a mouth, a side wall continuous with the mouth, and a bottom continuous with the side wall, and a lid that is fitted onto the mouth, and in the sealing process, the lid is fitted onto the container body that stores the powder.

[0009] Powder sealed in a transparent container is inspected with high accuracy for contamination with foreign matter, and a powder-sealed container with a low rate of contamination with foreign matter is manufactured.

[0010] (3) Preferably, in the inspection process, the first direction and the second direction are perpendicular to each other, and the support portion supports a third direction in which the mouth portion and the bottom portion face each other perpendicular to the first direction and the second direction, and the flowing powder is photographed through the side wall.

[0011] Since the powder that has accumulated on the bottom side of the transparent container flows along the side wall, foreign matter in the powder is easily exposed and tends to appear in the captured image.

[0012] (4) Preferably, the third direction is inclined with respect to the horizontal direction with the mouth portion being higher than the bottom portion.

[0013] Since the powder flowing along the side wall of the transparent container is located on the bottom side, it is easy to limit the range in which an image is captured.

[0014] (5) Preferably, in the inspecting step, the flowing powder is photographed from below the transparent container.

[0015] Since the image captures the state in which the powder, which is flowing inside the transparent container and falling due to gravity, collides with the transparent container which is vibrating back and forth, foreign matter is likely to appear in the captured image.

[0016] (6) Preferably, the powder has an angle of repose within a range of 30 degrees to 60 degrees. Effect of the Invention

[0017] According to the present invention, the presence of foreign matter in the powder inside a transparent container can be determined with high accuracy, so that a powder-sealed container with a low rate of foreign matter contamination can be obtained. [Brief description of the drawings]

[0018] [Figure 1] FIG. 1 is a perspective view of a vial 20. [Diagram 2] FIG. 2 is a schematic diagram of the foreign matter inspection device 10. As shown in FIG. [Diagram 3] FIG. 3 is a diagram showing the inclination of the vial 20 held by the clamp 12. As shown in FIG. [Figure 4] FIG. 4 is a diagram showing powder 21 undergoing elliptical motion within vial 20. As shown in FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0019] Hereinafter, an embodiment of the present invention will be described with reference to the drawings as appropriate. Note that the embodiment described below is merely one example of the present invention, and it goes without saying that the embodiment of the present invention can be modified as appropriate without changing the gist of the present invention. Note that in the following description, a vertical direction 5 is defined based on the top and bottom, a front-back direction 6 (a direction perpendicular to the paper surface of FIG. 2) is defined as a direction perpendicular to the vertical direction 5, and a left-right direction 7 is defined as a direction perpendicular to the vertical direction 5 and the front-back direction 6, respectively.

[0020] [Vial 20 and Powder 21] As shown in FIG. 1, an object to be inspected by a foreign matter inspection device 10 described later is a vial 20 (an example of a transparent container and a powder-enclosed container) containing a powder 21. Although not shown, the vial 20 is sealed by a known method, for example, by rolling up a lid 22 and a container body 23 with an aluminum cap. The powder 21 is a drug such as an injection, a powder, a fine granule, or a granule. The drug is not particularly limited, but is preferably, for example, a cell wall synthesis inhibitory antibiotic, a cell membrane inhibitory antibiotic, a nucleic acid synthesis inhibitory antibiotic, a protein synthesis inhibitory antibiotic, a folate metabolic pathway inhibitory antibiotic, a β-lactamase inhibitor, a sulfa drug, or an anti-infective drug. In addition, the drugs include ampicillin, bacampicillin, amoxicillin, pivmecillinam, amoxicillin, sultamicillin, piperacillin, aspoxilin, benzylpenicillin, cloxacillin, oxacillin, carbenicillin, cephalosporin, cefroxadine, cefadroxil, cefixime, cefteram pivoxil, cefuroxime axetil, cefpodoxime proxetil, and cefotiam. Hexetil, cefdinir, ceftibuten, cefditoren pivoxil, cefcapene pivoxil, cefazolin, cefozopran, cefmetazole, cefotiam, cefsulodin, cefoperazone, cefotaxime, cefmenoxime, ceftriaxone, ceftazisim, cefodisim, cefpirome, cefepime, faropenem, imipenem, panipenem, meropenem, biapenem, doripenem, aztreo Nam, vancomycin, teicoplanin, fosmicin, polymyxin B sulfate, colistin sulfate, gramicidin S, amphotericin B, levofloxacin, ofloxacin, norfloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, gatifloxacin, prulifloxacin, moxifloxacin, pazufloxacin, rifampicin, dibekacin, tobramycin, amikacin, isepamicin, micronomycin, streptomycin, kanamycin, gentamicin, erythromycin, rokitamycin, josamycin, roxromycin, clarithromycin, azithromycin, telithromycin, doxycycline, minocycline, chloramphenicol, lincomycin, clindamycin, trimethoprim, clavulanic acid,Sulbactam, tazobactam, sulfamethoxazole, salazopyrin, isoniazid, rifampicin, pyrazinamide, ethambutol, griseofulvin, amphotericin B, 5-fluorocytosine, fluconazole, miconazole, itraconazole, acyclovir, ganciclovir, foscavir, idoxuridine, amantadine, interferon gamma, ribavirin, lamipudine, metronidazole, tinidazole, fluconazole, meben dazole, pyrantel pamoate, diethylcarbamazine, praziquantel, albendazole, ivermectin, quinupristin, dalfopristin, linezolid, spectinomycin, netilmicin, sisomycin, lincosamin, ramoplanin, telithromycin, nystatin, fusidic acid, chlorhexidine, and polyhexanid.

[0021] The characteristics of the powder 21 include, for example, the angle of repose, the particle size, the filling amount, and the bulk density. The angle of repose of the powder 21 is specifically in the range of 30 degrees to 60 degrees, and preferably in the range of 33 degrees to 60 degrees. The particle size of the powder 21 is specifically in the range of 20 μm to 70 μm in terms of average particle diameter (median diameter: d50), and preferably in the range of 21.1 μm to 55.7 μm. The filling amount of the powder 21 contained in the vial 20 is at least 0.25 g or more, and even if the filling amount is large, it is possible to inspect it by the foreign matter inspection device 10. The bulk density of the powder 21 is specifically in the range of 0.300 g / mL to 0.700 g / mL, and preferably in the range of 0.340 g / mL to 0.670 g / mL.

[0022] As shown in Fig. 1, vial 20 (an example of a transparent container) has a lid 22 and a container body 23. The lid 22 is molded from a resin such as rubber or elastomer. The container body 23 is made of, for example, transparent glass. The container body 23 only needs to have a degree of translucency that allows the photographing device 15 (see Fig. 2) to optically photograph powder 21 in the internal space.

[0023] The container body 23 has a mouth 24, a side wall 25, and a bottom 26 that form an opening leading to the internal space. The container body 23 is generally cylindrical overall, and is a so-called narrow-mouth container in which the outer diameter of the mouth 24 is smaller than the outer diameter of the side wall 25. The mouth 24 and the bottom 26 face each other. The bottom 26 is disk-shaped, and the container body 23 stands with the opening of the mouth 24 facing upward when the bottom 26 is placed on a desk or the like. The side wall 25 is cylindrical. The mouth 24 is continuous with the side wall 25. The mouth 24 has a shape in which the outer diameter gradually expands toward the side wall 25. The side wall 25 and the bottom 26 are continuous. The outer diameter of the side wall 25 and the outer diameter of the bottom 26 are equal.

[0024] The lid 22 has a shape in which a convex portion protrudes from a disk that is in close contact with the mouth portion 24 and fits into the opening formed by the mouth portion 24. For example, the powder 21 is filled into the container body 23 by a filling machine, the lid 22 is plugged into the mouth portion 24, and an aluminum cap is rolled and tightened to seal the container body 23.

[0025] [Foreign substance inspection device 10] The foreign matter inspection device 10 inspects whether or not a foreign matter is present in the powder 21 sealed in the vial 20. As shown in FIG. 2, the foreign matter inspection device 10 includes a frame 11, a clamp 12 (an example of a support unit), a vibration generator 13, a composite vibration generator 14, an image capture device 15, an analysis device 16, and a lighting device 17. The support unit 12, the vibration generator 13, the composite vibration generator 14, and the image capture device 15 are supported by the frame 11. The frame 11 can change its posture so that the front-rear direction 6 is inclined from the horizontal direction while supporting the support unit 12, the vibration generator 13, the composite vibration generator 14, and the image capture device 15. The analysis device 16 is connected to the image capture device 15 so as to be able to communicate data with the image capture device 15.

[0026] Clamps 12 form a pair separated in the left-right direction 7, and each moves in the left-right direction 7 to change between a state in which vial 20 is clamped and a state in which vial 20 is not clamped. Clamps 12 clamp side wall 25 of vial 20 from the left-right direction 7. When clamps 12 are clamping vial 20, the direction in which mouth 24 and bottom 26 face each other (an example of a third direction), i.e., the axial direction of container body 23, is parallel to front-rear direction 6. In addition, when the clamp 12 is holding the vial 20 , a portion of the side wall 25 of the vial 20 is exposed in the up-down direction 5 .

[0027] The vibration generator 13 is fixed to each of the pair of clamps 12 at a position not in contact with the vial 20. The vibration generator 14 generates vibrations, for example, by rotation of an eccentric motor. The vibrations generated by the vibration generator 13 are transmitted to the vial 20 via the clamps 12.

[0028] The composite vibration generating device 14 applies reciprocating vibration in a vertical direction 5 (an example of a first direction) and a left-right direction 7 (an example of a second direction) to the clamp 12. The composite vibration generating device 14 has a motor 40, a vertical vibration generating mechanism 41, and a left-right vibration generating mechanism 42. The motor 40 generates a driving force that is transmitted to the vertical vibration generating mechanism 41 and the left-right vibration generating mechanism 42.

[0029] The vertical vibration generating mechanism 41 has an eccentric disk cam 43, a camshaft 44, a link arm 45, and a slider 46. The eccentric disk cam 43 is rotatably supported by a camshaft 44 that is supported by the frame 11 and extends along the front-rear direction 6. The camshaft 44 is provided with an eccentric disk cam 43. The eccentric disk cam 43 protrudes in the radial direction from the camshaft 44. The length by which the eccentric disk cam 43 protrudes from the camshaft 44 changes continuously in the circumferential direction of the camshaft 44.

[0030] Link arm 45 is slidably fitted with eccentric disk cam 43. When rotation of eccentric disk cam 43 is transmitted to link arm 45, link arm 45 rotates while its position is displaced in vertical direction 5. Link arm 45 is connected to slider 46 via shaft 47. Slider 46 is movable along vertical direction 5 by fitting with slide rail 54 provided on slider 51 of left-right vibration generating mechanism 42. Therefore, slider 46 reciprocates in vertical direction 5 according to the movement width in vertical direction 5 of the rotation of link arm 45.

[0031] The link arm 45 has a support arm 55 extending along the left-right direction 7. The support arm 55 supports the clamp 12 and the vibration generator 14.

[0032] The left-right vibration generating mechanism 42 has an eccentric disk cam 48, a camshaft 49, a link arm 50, and a slider 51. The eccentric disk cam 48 is rotatably supported by a camshaft 49 that is supported by the frame 11 and extends along the front-rear direction 6. The camshaft 49 is provided with the eccentric disk cam 48. The eccentric disk cam 48 protrudes radially from the camshaft 49. The length by which the eccentric disk cam 48 protrudes from the camshaft 49 changes continuously in the circumferential direction of the camshaft 49.

[0033] The link arm 50 is slidably fitted with the eccentric disk cam 48. When the rotation of the eccentric disk cam 48 is transmitted to the link arm 50, the link arm 50 rotates while its position is displaced in the left-right direction 7. The link arm 50 is connected to a slider 51 via a shaft 52. The slider 51 is movable along the left-right direction 7 by fitting into a slide rail 53 provided on the frame 11. Therefore, the slider 51 reciprocates in the left-right direction 7 depending on the movement width in the left-right direction 7 of the rotation of the link arm 50.

[0034] A slide rail 54 extending in the vertical direction 5 is formed on the left end of the slider 51. The slide rail 54 is fitted into the slider 46 of the vertical vibration generating mechanism 41. The reciprocating movement of the slider 51 in the left-right direction 7 is transmitted to the slider 46 via the slide rail 54. As a result, the slider 46 reciprocates in the vertical direction 5 while also reciprocating in the left-right direction 7. In other words, a composite vibration of the reciprocating movement in the left-right direction 7 and the reciprocating movement in the vertical direction 5 is transmitted to the support arm 55.

[0035] If the amplitude of the reciprocating movement in the up-down direction 5 by the up-down vibration generating mechanism 41 and the amplitude of the reciprocating movement in the left-right direction 7 by the left-right vibration generating mechanism 42 are the same, the composite vibration becomes any one of circular motion, linear motion, and elliptical motion by adjusting the phase difference of the eccentric disk cams 43, 48. For example, the phase difference of the eccentric disk cams 43, 48 is set so that the composite vibration becomes elliptical motion.

[0036] The photographing device 15 is installed below the clamp 12. The photographing device 15 is a camera that optically photographs the powder 21 in the vial 20 through a part of the side wall 25 exposed in the up-down direction 5 of the vial 20 held by the clamp 12. The photographing device 15 photographs multiple images of the vibrating vial 20 in a predetermined period of time, for example, at a frame rate of 30 or 60 frames per second.

[0037] The analysis device 16 is a computer in which judgment software is installed, which analyzes the image captured by the photographing device 15 and judges whether a foreign object is mixed in the powder 21. The analysis device 16 is connected to the photographing device 15 so as to be able to transmit and receive data. The analysis device 16 has, for example, input devices such as a keyboard and a mouse, and a display device such as a display. The image received from the photographing device 15 may be displayed on the display of the analysis device 16.

[0038] The judgment software judges whether a foreign object is mixed in the powder 21 of the vial 20 based on the image of the vial 20 photographed by the photographing device 15, that is, the image data. Specifically, the obtained one piece of image data is divided into a predetermined number of vertical and horizontal sub-areas, and the color density of each area is identified into multiple stages. If the powder 21 is white, the foreign object is recognized as black. Then, the judgment software judges whether a foreign object exists based on the peak value (color density of the foreign object) and the intensity area value (length x width of the foreign object) in the image data. For example, if both the peak value and the intensity area value are within a predetermined condition, for example, if each value is equal to or greater than a threshold value and there is a continuous predetermined range, the judgment software judges that a foreign object exists in the powder 21 of the vial 20. Note that there is no particular limitation on the detectable foreign object, and it is sufficient if it appears in the image with a brightness different from that of the powder 21.

[0039] Illumination devices 17 are installed above and below clamp 12. The two illumination devices 17 irradiate light from each of the upper and lower directions 5 onto vial 20 that is held in clamp 12 and vibrated. Illumination device 17 located below clamp 12 does not overlap with the area where image capturing device 15 and clamp 12 face each other, and is offset in the front-rear direction 6 from said area.

[0040] [Method of manufacturing vial 20 containing powder 21] A method for manufacturing the vial 20 containing the powder 21 will be described below. The method for manufacturing the vial 20 includes the following steps. (1) A process of sealing powder 21 in a vial 20. (2) An inspection step for inspecting the powder 21 for foreign matter (an example of an inspection method). (3) A defective product selection process in which a vial 20 determined to contain a foreign object in the powder 21 is deemed to be defective.

[0041] In the sealing process, powder 21 is filled into container body 23 by an auger type filling machine. Then, lid 22 is attached to container body 23 storing powder 21, and an aluminum cap is rolled and tightened to seal the boundary between lid 22 and container body 23. This results in vial 20 with powder 21 sealed in the internal space.

[0042] The inspection process is performed using a foreign matter inspection device 10. A vial 20 having powder 21 sealed in the internal space is clamped and held by a clamp 12 of the foreign matter inspection device 10. An axial direction C (see FIG. 3) of the vial 20 clamped and held by the clamp 12 is parallel to the front-rear direction 6.

[0043] When the foreign matter inspection device 10 is operated, the frame 11 is tilted. As shown in Fig. 3, when the frame 11 is tilted, the axial direction C of the vial 20 is tilted with respect to the front-rear direction 6 (horizontal direction) with the mouth 24 of the container body 23 being above the bottom 26. The tilt angle is within a range of 0 degrees to 15 degrees, and preferably within a range of 1 degree to 10 degrees. When the foreign matter inspection device 10 is operated, the lighting device 17 is turned on.

[0044] After the frame 11 is tilted, the vibration generator 13 is operated and the motor 40 is also operated. By operating the vibration generator 13, vibration is applied to the vial 20 held by the clamp 12. By applying vibration to the vial 20, even if the powder 21 is attached to the side wall 25 inside the vial 20, the powder 21 is separated from the side wall 25 by the vibration. Furthermore, clumps of the powder 21 are broken down. As a result, foreign matter mixed in the powder 21 is more likely to appear on the inner surface side of the side wall 25 of the vial 20.

[0045] When the motor 40 is operated, the composite vibration generator 14 applies a composite vibration to the vial 20 that forms an elliptical motion when viewed from the front-rear direction 6. This composite vibration causes the powder 21 to flow while circulating in an ellipse in the internal space of the vial 20, as shown in FIG. 4. In this flow of the powder 21, foreign matter that is different in size or weight from each particle of the powder 21 flows differently from the powder 21. For example, foreign matter that is heavier than each particle of the powder 21 tends to move to the outside of the circulation of the flowing powder 21, and is therefore likely to appear on the inner surface side of the side wall 25 of the vial 20.

[0046] In addition, since the axial direction C of the vial 20 is inclined with respect to the front-rear direction 6 with the mouth 24 of the container body 23 being higher than the bottom 26, the powder 21 tends to accumulate on the bottom 26 side. Furthermore, foreign matter that is heavier than each particle of the powder 21 tends to move toward the bottom 26 side from the powder 21, and therefore tends to appear on the inner surface side of the side wall 25 near the bottom 26 of the vial 20.

[0047] The analysis device 16 determines whether or not there is a foreign object in the powder 21 inside the vial 20 based on the image of the vial 20 captured by the image capture device 15 while the vibration and the combined vibration are being applied to the vial 20.

[0048] In the defective product screening process, vials 20 determined to contain foreign matter in powder 21 are excluded from shipping as defective products.

[0049] [Effects of the embodiment] According to the embodiment described above, in the inspection process, the vibration applied through the clamp 12 breaks up lumps of the powder 21 in the vial 20, and the powder 21 separates from the side wall 25, making the powder 21 more likely to scatter. In addition, the combined vibration in the vertical direction 5 and the horizontal direction 7 causes the powder 21 to flow in a circulating manner in the vial 20. As a result, the powder 21 flows while scattering in the vial 20, so that foreign matter in the powder 21 is more likely to be exposed in the inspection process, and the foreign matter is more likely to appear in a photographed image. In addition, in the defective product selection process, the vials 20 determined to contain foreign matter are deemed defective, so the rate of foreign matter contamination in the manufactured vials 20 is low.

[0050] In the inspection process, the axial direction C of the vial 20 is supported so as to be parallel to the front-rear direction 6, so that the flowing powder 21 is photographed through the side wall 25 of the vial 20.

[0051] In addition, in the inspection process, since the axial direction C of the vial 20 is inclined from the front-rear direction 6, the powder 21 accumulated on the bottom 26 side of the vial 20 flows along the side wall 25. This makes it easy for foreign matter in the powder 21 to be exposed, and the foreign matter is likely to appear in the captured image. In addition, since foreign matter is likely to appear near the bottom 26 of the side wall 25 of the vial 20, the range in which an image is captured for determining foreign matter is limited.

[0052] In addition, in the inspection process, the flowing powder 21 is photographed from below the vial 20, so the state in which the powder 21 that falls due to gravity while flowing inside the vial 20 collides with the side wall 25 of the vibrating container body 23 is photographed. This makes it easy for foreign matter to appear in the photographed image. [Explanation of symbols]

[0053] 10 Foreign body inspection device 11. Frame 12 Clamp (support part) 13. Vibration generator 14. Composite vibration generator 15. Imaging device 16...Analysis equipment 20 vials 21...Powder 22...lid 23... Container body 24...mouth 25...side wall 26...Bottom

Claims

1. An encapsulation step of encapsulating powder in a transparent container; an inspection step of inspecting the powder for foreign matter; a defective product sorting step for classifying the transparent container determined to contain a foreign matter as a defective product, The transparent container has a container body having a mouth, a side wall continuous with the mouth, and a bottom continuous with the side wall, and a lid that is fitted onto the mouth, In the sealing step, the lid is plugged onto the container body storing the powder, The above inspection process is as follows: a support part supporting the transparent container supports the transparent container so that a third direction in which the mouth part and the bottom part face each other is perpendicular to the first direction and a second direction perpendicular to the first direction, and intersects with the vertical direction; and a composite vibration of a reciprocating vibration in the first direction and a reciprocating vibration in the second direction is applied to the support part to cause the powder in the transparent container to flow, while a vibration different from the composite vibration is applied to the transparent container via the support part; The flowing powder is optically photographed from below the transparent container through a side wall of the transparent container while irradiating the transparent container with light from above and below; A method for manufacturing a powder-containing container in which a photographed image is divided into a predetermined number of vertical and horizontal regions, the black and white intensity in each of the regions is identified into multiple levels of intensity, and whether or not a foreign object is present in the powder is determined based on whether or not there is a predetermined range in which each of the regions, in which the identified black and white intensity is equal to or above a threshold value for recognition as black, is continuous vertically or horizontally.

2. The method for manufacturing a powder-containing container according to claim 1 , wherein the third direction is inclined with respect to the horizontal direction such that the mouth is above the bottom.

3. 3. The method for manufacturing a powder-containing container according to claim 1, wherein the powder has an angle of repose within a range of 30 degrees to 60 degrees.

4. A method for manufacturing a powder-filled container described in any of claims 1 to 3, wherein the average particle diameter of the powder is within the range of 20 μm to 70 μm.

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