External composition

Abstract

To provide an external composition excellent in suppression of heat sensation and suppression of dryness and having superior applicability.SOLUTION: An external composition contains (A) a UV protection agent, (B) hyaluronic acid with a weight average molecular weight of less than 20,000 or a salt thereof, (C) hyaluronic acid with a weight average molecular weight of 20,000 or more or a salt thereof, and (D) a hyaluronic acid derivative.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a topical composition. [Background technology]

[0002] In order to protect the human body from harmful rays such as ultraviolet rays in various situations in daily life, attempts have been made to incorporate ultraviolet protection agents into topical compositions. There have been many difficulties in realizing topical compositions that are excellent in terms of effectiveness in protecting the human body from the harmful effects of ultraviolet rays and in terms of usability. Topical compositions applied to the surface of the human body are easily lost from the surface of the human body due to sweat, rubbing with clothing, etc., and therefore there is a demand for topical compositions that can be used to protect against ultraviolet rays throughout the day.

[0003] Attempts have been made to achieve UV protection effects and a good feel when used by setting the total amount and blending ratio of higher alcohol and surfactant within a specific range (Patent Document 1), but if there is too much higher alcohol, the application becomes difficult and sticky, which is insufficient. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2010-189281 A Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide a composition for external use which is excellent in suppressing the sensation of heat and the sensation of dryness and has good applicability. [Means for solving the problem]

[0006] The present inventors have discovered that a composition for external use containing (A) an ultraviolet protection agent, (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative, can suppress the sensation of heat and dryness, and exhibit good application properties.

[0007] The present invention has been completed based on the above findings, and provides the following composition for external use.

[0008] That is, the present invention provides [1] A composition for external use comprising (A) an ultraviolet protection agent, (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative; [2] The composition for external use according to [1], wherein (A) the ultraviolet protection agent is at least one selected from the group consisting of an ultraviolet absorbing agent and an ultraviolet scattering agent; [3] (B) the composition for external use according to [1] or [2], in which the content of hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000 is 0.0001 to 0.8% by mass based on the total amount of the composition for external use; [4] (C) the composition for external use according to any one of [1] to [3], wherein the content of hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more is 0.001 to 1 mass% based on the total amount of the composition for external use; [5] (D) the composition for external use according to any one of [1] to [4], wherein the content of the hyaluronic acid derivative is 0.00001 to 0.3% by mass based on the total amount of the composition for external use; [6] (D) the composition for external use according to any one of [1] to [5], containing 1 to 30,000 parts by mass of an ultraviolet protection agent (A) per 1 part by mass of a hyaluronic acid derivative; [7] (D) The composition for external use according to any one of [1] to [6], wherein the hyaluronic acid derivative is one or more selected from the group consisting of acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, hydrolyzed alkyl hyaluronate (alkyl group having 12 to 13 carbon atoms) glyceryl, crosslinked hyaluronic acid, carboxymethyl hyaluronic acid, propylene glycol hyaluronate, dimethylsilanol hyaluronate, and salts thereof; [8] The composition for external use according to any one of [1] to [7], containing 0.0001 to 5,000 parts by mass of the (D) component per 1 part by mass of the total content of the (B) component and the (C) component; [9] (E) the composition for external use according to any one of [1] to [8], which contains a nonionic surfactant;

[10] (E) The composition for external use according to [9], wherein the nonionic surfactant is at least one selected from the group consisting of polyglycerin fatty acid esters, polyoxyethylene fatty acid esters, and polyether-modified silicones;

[11] (E) The composition for external use according to [9] to

[10] , wherein the content of the nonionic surfactant is 2% by mass or less;

[12] The composition for external use according to any one of [1] to

[11] , which is an oil-in-water type;

[13] A heat sensation suppressant comprising the topical composition according to any one of [1] to

[12] .

[14] An agent for suppressing dryness, comprising the topical composition according to any one of [1] to

[12] .

[15] A coatability improver comprising the topical composition according to any one of [1] to

[12] .

[16] A method for improving the applicability of a topical composition, comprising blending (A) a topical composition containing an ultraviolet protection agent with (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative; etc. Effect of the Invention

[0009] The topical composition of the present invention contains (A) an ultraviolet protection agent, (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative, and therefore reduces the sensation of heat and dryness and has excellent application properties. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] Hereinafter, the embodiments for carrying out the present invention will be described in detail. However, the present invention is not limited to the following embodiments. In this specification, the term "salt" is not particularly limited as long as it is medicamentarily, pharmacologically, or physiologically acceptable. Specifically, it includes basic salts such as salts with inorganic bases, such as alkali metal salts, alkaline earth metal salts, and typical metal salts, and salts with organic bases. "Salt" includes solvates and hydrates of salts.

[0011] [1. External composition] The topical composition according to this embodiment is a topical composition containing (A) an ultraviolet protection agent (also referred to simply as "component (A)"), (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000 (also referred to simply as "component (B)"), (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more (also referred to simply as "component (C)"), and (D) a hyaluronic acid derivative (also referred to simply as "component (D)").

[0012] <Component (A)> The ultraviolet protection agent may be used alone or in combination of two or more kinds. Examples of the component (A) include components with ultraviolet protection properties such as oil-soluble ultraviolet absorbers, water-soluble ultraviolet absorbers, and ultraviolet scattering agents. Specific examples include 2-ethylhexyl paramethoxycinnamate, dimethicodimethyi benzalmalonate, octocrylene, diethylamino hydroxybenzoyl benzoic acid hexyl ester, paraaminobenzoic acid, 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, 4-tert-butyl-4'-methoxydibenzoylmethane, homomenthyl salicylate, and ethylhexyl salicylate. , octyl salicylate, oxybenzone, and dihydroxydimethoxybenzophenone; one or more water-soluble UV absorbers selected from the group consisting of phenylbenzimidazole sulfonic acid, hydroxymethoxybenzophenone sulfonate, terephthalidenedicamphorsulfonic acid, 4-(2-β-glucopyranosyloxy)propoxy-2-hydroxybenzophenone, and phenylene-1,4-bis(2-benzimidazyl)-3,3'-5,5'-tetrasulfonic acid bis-sodium salt; one or more metal oxides selected from the group consisting of zinc oxide, titanium oxide, cerium oxide, and zirconium oxide; etc. The solubility of the oil-soluble UV absorber in water at 25°C is less than 0.01% by mass, and the solubility of the water-soluble UV absorber in water at 25°C is 0.01% by mass or more. The metal oxide is not particularly limited in terms of shape (e.g., spherical, plate-like, needle-like, etc.), particle size (e.g., mist-like, fine particles, pigment-grade, etc.), particle structure (e.g., porous, non-porous, etc.), etc., and may be surface-treated by a known surface treatment method. Component (A) can be a commercially available product.

[0013] The content of component (A) in the topical composition according to the present embodiment is not particularly limited, and is appropriately set depending on the type of component (A), the type and content of other blended components, the use of the topical composition, the formulation form, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content of component (A) may be, for example, 1 to 50% by mass, preferably 1 to 45% by mass, more preferably 1 to 40% by mass, even more preferably 1 to 35% by mass, even more preferably 2 to 35% by mass, particularly preferably 2 to 33% by mass, and most preferably 3 to 30% by mass, based on the total amount of the topical composition.

[0014] <(B) component> The hyaluronic acid or salt thereof having a weight-average molecular weight of less than 20,000 may be used alone or in combination of two or more kinds. Component (B) can be obtained by extraction, recovery, and purification from animal tissues such as chicken combs, shark skin, umbilical cords, eyeballs, skin, and cartilage, or from cultures of hyaluronic acid-producing microorganisms such as Streptococcus genus microorganisms, animal cells, and plant cells. Hyaluronic acid or its salts having a weight-average molecular weight of less than 10,000 can also be obtained by decomposing hyaluronic acid or fractionating and purifying it. Decomposition can be performed, for example, by hydrolysis in the presence of acid or alkali, enzyme treatment with hyaluronidase, physical cutting such as ultrasonic waves or shearing, or fermentation by microorganisms. Fractionation and purification can be performed by known methods such as filtration. In addition, commercially available products can be purchased, such as Hyalo Oligo (trade name) (Kewpie Corporation; weight-average molecular weight less than 10,000), Hyaluronic Acid (SL) (trade name) (FAP Japan Co., Ltd.; weight-average molecular weight less than 10,000), Micro Hyaluronic Acid FCH (trade name) (Kikkoman Biochemifa Corporation; weight-average molecular weight 5000 or less), and HAbooster (trade name) (Kewpie Corporation; weight-average molecular weight 2000). When hyaluronic acid oligosaccharide and / or its salt is used, about 2 to 16 sugars are preferable, and either saturated or unsaturated type may be used.

[0015] The weight average molecular weight of the (B) component is less than 20,000, but from the viewpoint of more significantly exhibiting the effects of the present invention, it is, for example, preferably 19,000 or less, more preferably 15,000 or less, even more preferably 12,000 or less, and particularly preferably 9,000 or less. It is also preferably 10 or more, more preferably 100 or more, even more preferably 300 or more, and particularly preferably 400 or more.

[0016] The content of the (B) component in the topical composition according to this embodiment is not particularly limited, and is appropriately set according to the type of the (B) component, the type and content of other blended components, the use of the topical composition, the formulation form, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content of the (B) component is, for example, preferably 0.0001% by mass or more, more preferably 0.0005% by mass or more, even more preferably 0.001% by mass or more, based on the total amount of the topical composition. In addition, the content of the (B) component is preferably 0.8% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, and even more preferably 0.1% by mass or less, based on the total amount of the topical composition.

[0017] <(C) component> The hyaluronic acid or salt thereof having a weight-average molecular weight of 20,000 or more may be used alone or in combination of two or more kinds. Component (C) can be obtained by extraction, recovery, and purification from animal tissues such as chicken combs, shark skin, umbilical cords, eyeballs, skin, and cartilage, and from cultures of hyaluronic acid-producing microorganisms such as Streptococcus microorganisms, animal cells, and plant cells. Hyaluronic acid or its salts having a weight-average molecular weight of 20,000 or more can also be obtained by decomposing hyaluronic acid or fractionating and purifying it. Decomposition can be performed, for example, by hydrolysis in the presence of acid or alkali, enzyme treatment with hyaluronidase, physical cutting such as ultrasonic waves or shearing, or fermentation by microorganisms. Fractionation and purification can be performed by known methods such as filtration. In addition, commercially available products can be purchased, such as sodium hyaluronate HA12N (trade name) (Shiseido Co., Ltd.; weight average molecular weight 1.1 to 1.6 million), hyaluronic acid FCH-150 (trade name) (Kikkoman Biochemifa Corporation; weight average molecular weight 1.4 to 1.8 million), bio sodium hyaluronate SZE (trade name) (Shiseido Co., Ltd.; weight average molecular weight 1.1 to 1.6 million), and hyaluronic acid FCH-120 (trade name) (Kikkoman Biochemifa Corporation; weight average molecular weight 100 to 1.4 million), Hyaluronic Acid HA-LQ (trade name) (Kewpie Corporation; weight-average molecular weight 850,000 to 1.6 million), Hyaluronic Acid FCH-80 (trade name) (Kikkoman Biochemifa Corporation; weight-average molecular weight 600,000 to 1 million), Hyaluronic Acid FCH-60 (trade name) (Kikkoman Biochemifa Corporation; weight-average molecular weight 500,000 to 700,000), and Hyaluronic Acid FCH-SU (trade name) (Kikkoman Biochemifa Corporation; weight-average molecular weight 500,000 to 110,000).

[0018] The weight average molecular weight of component (C) is 20,000 or more, but from the viewpoint of more significantly exhibiting the effects of the present invention, it is, for example, preferably 50,000 or more, more preferably 100,000 or more, even more preferably 300,000 or more, and particularly preferably 500,000 or more. It is also preferably 7 million or less, more preferably 6 million or less, even more preferably 4 million or less, even more preferably 3 million or less, and particularly preferably 2 million or less.

[0019] The content of the (C) component in the topical composition according to this embodiment is not particularly limited, and is appropriately set according to the type of the (C) component, the type and content of other blended components, the use of the topical composition, the formulation form, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content of the (C) component is, for example, preferably 0.001% by mass or more, more preferably 0.005% by mass or more, even more preferably 0.01% by mass or more, and even more preferably 0.02% by mass or more, based on the total amount of the topical composition. In addition, the content of the (C) component is preferably 1.0% by mass or less, more preferably 0.8% by mass or less, even more preferably 0.6% by mass or less, and even more preferably 0.3% by mass or less, based on the total amount of the topical composition.

[0020] <(D) component> The hyaluronic acid derivatives may be used alone or in combination of two or more. Among the (D) components, from the viewpoint of exhibiting the effects of the present invention more significantly, acetylated hyaluronic acid, sulfated hyaluronic acid, hydrophobized hydrolyzed hyaluronic acid (hydrolyzed alkyl hyaluronate, hydrolyzed glyceryl hyaluronate, etc.), crosslinked hyaluronic acid, carboxymethyl hyaluronic acid, alkylene glycol hyaluronate, silanol hyaluronate, cationized hyaluronic acid, and salts thereof can be mentioned.Preferably, acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, hydrolyzed alkyl hyaluronate (alkyl group having 12 to 13 carbon atoms) glyceryl, crosslinked hyaluronic acid, carboxymethyl hyaluronic acid, propylene glycol hyaluronate, dimethylsilanol hyaluronate, and salts thereof are preferred, and among them, acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, crosslinked hyaluronic acid, propylene glycol hyaluronate, dimethylsilanol hyaluronate, and salts thereof can be mentioned. More preferred are acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, and salts thereof. In addition, commercially available products can be purchased, such as acetylated sodium hyaluronate (trade name) (Shiseido Co., Ltd.; weight average molecular weight 10,000 to 100,000), Hyalobell (trade name) (Kewpie Corporation; weight average molecular weight 500,000 to 800,000), HyaloRepea (trade name) (Kewpie Corporation; weight average molecular weight 10,000 or less), Hyalocatch (trade name) (Kewpie Corporation; weight average molecular weight 800,000 to 1,200,000), Hyalujon (trade name) (Kikkoman Biochemifa Corporation; propylene glycol hyaluronate), Hyalucage System (trade name) (IRAsrl; cross-linked three-dimensional hyaluronic acid; weight average molecular weight 7 million), DSHCN6 (trade name) (EXSYMOL SAM; dimethylsilanol hyaluronate), and DSHCN (trade name) (EXSYMOL SAM; dimethylsilanol hyaluronate).

[0021] The content of the (D) component in the external composition according to this embodiment is not particularly limited, and is appropriately set according to the type of the (D) component, the type and content of other blended components, the use of the external composition, the formulation form, etc. From the viewpoint of more clearly demonstrating the effects of the present invention, the content of the (D) component is, for example, preferably 0.00001% by mass or more, more preferably 0.00004% by mass or more, even more preferably 0.00008% by mass or more, and even more preferably 0.0001% by mass or more, based on the total amount of the external composition. In addition, the content of the hyaluronic acid derivative is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, and even more preferably 0.025% by mass or less, based on the total amount of the external agent for skin.

[0022] In this embodiment, the weight average molecular weight is a value measured by size exclusion chromatography. The conditions are as follows: Column: TSKgel GMPWXL 7.8mm x 30cm (Tosoh Corporation) Column temperature: constant temperature around 40℃ Detector: Differential refractometer Mobile phase: 0.2mol / L NaCl Flow rate: 0.3mL / min Injection volume: 100μL Standard substance: Pullulan standard (STANDARD P-82, Showa Denko K.K.)

[0023] <(E) component> The topical composition according to this embodiment may further contain (E) a nonionic surfactant (also referred to simply as "component (E)"). When the topical composition further contains component (E), the effects of the present invention are more pronounced. There are no particular limitations on component (E) as long as it is one that is commonly used in topical compositions.

[0024] Examples of component (E) include polyglycerin fatty acid esters such as polyglyceryl monostearate, polyglyceryl monoisostearate, polyglyceryl diisostearate, and polyglyceryl pentaisostearate; polyoxyethylene fatty acid esters such as polyethylene glycol monostearate, polyethylene glycol stearate, and polyethylene glycol isostearate; polyoxyethylene hydrogenated castor oil; sucrose fatty acid esters; polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, and polyoxyethylene tristearate. Examples of surfactants include sorbitan fatty acid esters such as sorbitan, polyoxyethylene sorbitan oleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; polyoxyethylene phytosterol; surfactants having an organosiloxane structure in the molecular structure such as polyether-modified silicone, alkyl-modified polyether-modified silicone, and alkyl-chain-co-modified polyether-modified silicone. Examples of surfactants having an organosiloxane structure in the molecular structure include polyoxyethylene-methylpolysiloxane copolymer, polysilicone-13 (poly(oxyethylene-oxypropylene)-butylene-methylpolysiloxane copolymer), lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone.

[0025] The content of the (E) component in the topical composition according to the present embodiment is not particularly limited, and is appropriately set according to the type of the (E) component, the type and content of other blended components, the use of the topical composition, the formulation form, etc. With respect to the content of the (E) component, from the viewpoint of more prominently exhibiting the effects of the present invention, for example, based on the total amount of the topical composition, the total content of the (E) component is preferably 2% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1.2% by mass or less, and particularly preferably 1.0% by mass. Based on the total amount of the topical composition, the total content of the (E) component is preferably 0 to 2% by mass, more preferably 0.01 to 1.8% by mass, even more preferably 0.05 to 1.5% by mass, even more preferably 0.08 to 1.2% by mass, and particularly preferably 0.1 to 1.0% by mass.

[0026] In the topical composition of this embodiment, the content ratio of the UV protection agent (A) per 1 part by mass of the hyaluronic acid derivative (D) is not particularly limited; however, from the viewpoint of more prominently exhibiting the effects of the present invention, for example, the total content of the component (A) per 1 part by mass of the total content of the component (D) contained in the topical composition of this embodiment is preferably 1 to 30,000 parts by mass, more preferably 5 to 20,000 parts by mass, even more preferably 10 to 10,000 parts by mass, even more preferably 10 to 5,000 parts by mass, and particularly preferably 10 to 3,000 parts by mass.

[0027] In the topical composition of this embodiment, the content ratio of the hyaluronic acid derivative (D) per 1 part by mass of the total content of the components (B) and (C) is not particularly limited; however, from the viewpoint of more prominently exhibiting the effects of the present invention, for example, the total content of the component (D) per 1 part by mass of the total content of the components (B) and (C) contained in the topical composition of this embodiment is preferably 0.0001 to 5000 parts by mass, more preferably 0.0005 to 2500 parts by mass, even more preferably 0.001 to 1000 parts by mass, even more preferably 0.005 to 100 parts by mass, and particularly preferably 0.01 to 10 parts by mass.

[0028] The topical composition according to the present embodiment may contain known ingredients used in cosmetics, quasi-drugs and pharmaceuticals, so long as they do not impair the effects of the present invention. In addition to the above (A) to (E) ingredients, for example, antioxidants, functional brightening ingredients, moisturizing agents, anti-inflammatory ingredients, antibacterial agents, vitamins, amino acids, biological extracts, and various pharmacologically active ingredients and physiologically active ingredients may be combined and contained in appropriate amounts. In addition, additives such as surfactants (excluding the above (E)), preservatives, pH adjusters, chelating agents, stabilizers, buffers, thickeners (excluding the above (B), (C) and (D)), gelling agents, irritation reducing agents, preservatives, colorants, fragrances, minerals and the like may be added alone or in combination of two or more. When silica is contained, it may be porous, non-porous, solid or hollow, and the average particle size is preferably 1 to 20 μm, more preferably 2 to 7 μm. In addition, it may contain one or more bases or carriers. These can be appropriately selected from known materials and can be produced by conventional methods.

[0029] The topical composition according to this embodiment can be prepared by, for example, mixing and stirring the components in accordance with a conventional method.

[0030] The external use composition according to the present embodiment is not particularly limited in the form of the drug, and can take the form known as cosmetics, quasi-drugs, or pharmaceuticals. Among such known forms, for example, liquids, suspensions, emulsions, creams, gels, liniments, ointments, lotions, aerosols, powders, poultices, sheets in which a sheet such as a nonwoven fabric is impregnated with a drug solution, and sticks such as lipsticks can be mentioned. Among them, liquids, suspensions, emulsions, creams, gels, and lotions are preferred in terms of good usability. The external use composition according to the present embodiment may be an oil-in-water (O / W) composition or a water-in-oil (W / O) composition. From the viewpoint of more prominently exerting the effects of the present invention, an oil-in-water composition is preferred. The cosmetic composition may also be used in the form of basic cosmetics such as milky lotion, cream, body lotion, body cream, and sunscreen, or in the form of makeup cosmetics such as foundation, lipstick, blusher, eye makeup, face powder, manicure, pedicure, etc. Sunscreen cosmetics are preferred.

[0031] The area to which the topical composition of this embodiment is applied is not particularly limited, and it can be applied to any of the face, arms, hands, feet, neck, scalp, etc.

[0032] 2. Suppression of the Heat Sensation of Topical Compositions The topical composition containing (A) ultraviolet protection agent according to this embodiment is suppressed from feeling hot at the application site by coexisting with (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative.Therefore, as one embodiment of the present invention, a method for suppressing the feeling of heat at the application site of the topical composition containing (A) ultraviolet protection agent is provided, which comprises coexisting with (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative.

[0033] The topical composition according to this embodiment, which contains (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative, suppresses the heat sensation at the application site by making (A) ultraviolet protection agent coexist.Therefore, as one embodiment of the present invention, a method for suppressing the heat sensation at the application site of the topical composition is provided, which includes making (A) ultraviolet protection agent coexist with the topical composition containing (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative.

[0034] In this embodiment, the type and content etc. of the (A) component, the content etc. of the (B) component, the content etc. of the (C) component, the type and content etc. of the (D) component, the type and content etc. of other components, the formulation form and use etc. of the topical composition are as described in [1. Topical composition].

[0035] 3. Suppression of dryness caused by topical compositions The topical composition containing (A) ultraviolet protection agent according to this embodiment is suppressed from feeling dry at the application site by making (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative coexist.Therefore, as one embodiment of the present invention, a method for suppressing feeling dry at the application site of the topical composition containing (A) ultraviolet protection agent is provided, which comprises making (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative coexist in the topical composition.

[0036] The topical composition according to this embodiment, which contains (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative, suppresses dryness at the application site by making (A) ultraviolet protection agent coexist.Therefore, as one embodiment of the present invention, a method for suppressing dryness at the application site of the topical composition is provided, which includes making (A) ultraviolet protection agent coexist with the topical composition containing (B) hyaluronic acid or its salt with a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt with a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative.

[0037] In this embodiment, the type and content etc. of the (A) component, the content etc. of the (B) component, the content etc. of the (C) component, the type and content etc. of the (D) component, the type and content etc. of other components, the formulation form and use etc. of the topical composition are as described in [1. Topical composition].

[0038] 4. Improvement of the applicability of the topical composition The topical composition containing (A) an ultraviolet protection agent according to this embodiment has improved applicability at the application site by coexisting (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative.Therefore, as one embodiment of the present invention, a method for improving the applicability at the application site of the topical composition containing (A) an ultraviolet protection agent is provided, which includes coexisting (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative.

[0039] The topical composition containing (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative according to this embodiment has improved applicability at the application site by coexisting with (A) ultraviolet protection agent.Therefore, as one embodiment of the present invention, a method for improving the applicability at the application site of the topical composition containing (B) hyaluronic acid or its salt having a weight average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight average molecular weight of 20,000 or more, and (D) hyaluronic acid derivative is provided, which includes coexisting with (A) ultraviolet protection agent.

[0040] In this embodiment, the type and content etc. of the (A) component, the content etc. of the (B) component, the content etc. of the (C) component, the type and content etc. of the (D) component, the type and content etc. of other components, the formulation form and use etc. of the topical composition are as described in [1. Topical composition].

[0041] The applicability of a composition for external use refers to the fact that the application site after application is prevented from feeling sticky, the stress caused by application is reduced, the feeling is moist, and the squeaky feeling is reduced. EXAMPLES

[0042] The present invention will be specifically described below based on test examples, but the present invention is not limited to these. In the following examples, the blending amounts are indicated as mass %.

[0043] [Test Example 1] A topical composition having the composition shown in Table 1 below was prepared according to a conventional method. A panel of five experts evaluated the sensation of heat, sensation of dryness, and applicability according to the evaluation criteria. Each evaluation was performed by five experts on the same day. The evaluation results are shown in Tables 1 and 2.

[0044] (Evaluation of heat sensation) Four grams of the topical composition was applied to the right forearm, and the skin was exposed to sunlight for four hours or more, after which the sensation of heat on the skin was evaluated. The sensation of heat was evaluated as a feeling of higher body temperature on the skin surface, or a hot flash-like sensation, compared to a part of the body (upper arm) that was covered with clothing and not exposed to sunlight. "Evaluation Criteria" ◎: The application site on the right forearm does not feel hot or flushed. 〇: The area on my right forearm where the patch was applied feels a little hot and flushed, but not uncomfortable. ×: The application site on the right forearm felt very hot and flushed. "Evaluation Results" A: 5 people rated it as ◎ B: 3 to 4 people rated it as ◎ (if one or more people rated it as ×, the rating will be D) C: 1 to 2 people rated it as ◎ (if 1 or more people rated it as ×, it will be rated D) D: One or more people rated it as ×

[0045] (Evaluation of dryness) Four grams of the topical composition was applied to the right forearm and exposed to sunlight for four hours or more. After that, the applied area was washed and wiped to remove moisture, and the dryness of the skin was evaluated. "Evaluation Criteria" ◎: No dry feeling on the application area of ​​the right forearm 〇: The application area on the right forearm feels a little dry, but not uncomfortable. ×: The application area on the right forearm felt very dry. "Evaluation Results" A: 5 people rated it as ◎ B: 3 to 4 people rated it as ◎ (if one or more people rated it as ×, the rating will be D) C: 1 to 2 people rated it as ◎ (if 1 or more people rated it as ×, it will be rated D) D: One or more people rated it as ×

[0046] (Evaluation of Coatability) One gram of the composition for external use was applied to the back of the hand three times every two hours. After the third application, the applied area was touched to evaluate the applicability. The applicability was evaluated based on whether the composition felt sticky or moist to the touch, which was considered stressful when applied. "Evaluation Criteria" ◎: No stickiness, leaves skin feeling fresh 〇: No sticky feeling ×: Sticky feeling "Evaluation Results" A: 5 people rated it as ◎ B: 3 to 4 people rated it as ◎ (if one or more people rated it as ×, the rating will be D) C: 1 to 2 people rated it as ◎ (if 1 or more people rated it as ×, it will be rated D) D: One or more people rated it as ×

[0047] (comprehensive evaluation) The evaluation was made by comprehensively assessing the three items of heat sensation, dryness sensation, and applicability. "Evaluation Criteria" ◎: Three items were rated as ◎ (If one or more items were rated as ×, the rating will be ×) ○: Two items were rated as ◎ (If one or more items were rated as ×, the rating will be ×) △: One item was rated as ◎ (If one or more items were rated as ×, the rating will be ×) ×: 1 to 3 items were rated × "Evaluation Results" A: 5 people rated it as ◎ B: 3 to 4 people rated it as ◎ C: 1-2 people rated it as ◎ D: One or more people rated it as ×

[0048] [Table 1]

[0049] [Table 2]

[0050] As shown in Tables 1 and 2, the topical composition containing (A) an ultraviolet protection agent, (B) hyaluronic acid or a salt thereof having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or a salt thereof having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative suppresses the sensation of heat and dryness and improves the applicability.

[0051] Panelists who rated the sensation of heat as ◎ or ○ patted the applied area with cotton soaked in lotion 20 times immediately after the evaluation and touched the skin surface. The better the evaluation result of the sensation of heat, the colder the skin surface felt. In the area of ​​the forearm where the topical composition was not applied, the skin surface did not feel cold or felt weakly cold. Since the more the amount of lotion at room temperature that penetrates into the skin surface layer, the colder the skin felt, it was thought that the topical composition of the present invention improves the permeability of moisture into the stratum corneum. It was thought that the topical composition of the present invention maintains and improves the moisture retention of the skin surface and stratum corneum during the time that the topical composition of the present invention is exposed to sunlight for several hours after application, due to the (B), (C), and (D) components.

[0052] From the evaluation of applicability, the topical composition of the present invention did not feel sticky even when repeatedly applied, and provided a fresh feeling to the skin, exhibiting good applicability. The topical composition of the present invention can be applied repeatedly and comfortably several times a day, making it an excellent topical composition that can be used to protect against ultraviolet rays throughout the day. The expert panel commented that the freshness felt stronger the more times it was applied. In daily life, topical compositions are unevenly removed due to sweat and friction from clothing, and the more times they are applied, the more uneven the surface of the application site becomes. Therefore, it was thought that the topical composition of the present invention can make the surface uniform and has high adhesion to the skin, thereby providing a fresh feeling.

[0053] Although not limited thereto, it is considered that the (B), (C), and (D) components interact with the skin surface and the surface layer to make the uneven surface uniform and smooth, and also serve as a base for the (A) UV protection agent to spread evenly within the applied film of the topical composition, so that the topical composition of the present invention can suppress a feeling of heat and dryness and has excellent applicability. Although not limited thereto, it is considered that the topical composition of the present invention is even more effective on skin where the unevenness increases due to repeated application to areas where the application of the topical composition has become uneven due to sweat or friction.

Claims

1. A topical composition containing (A) an ultraviolet protection agent, (B) hyaluronic acid or its salt having a weight-average molecular weight of less than 20,000, (C) hyaluronic acid or its salt having a weight-average molecular weight of 20,000 or more, and (D) a hyaluronic acid derivative.

2. The topical composition according to claim 1, wherein the (D) hyaluronic acid derivative is one or more selected from the group consisting of acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, hydrolyzed alkyl hyaluronate (alkyl group having 12 to 13 carbon atoms) glyceryl, crosslinked hyaluronic acid, carboxymethyl hyaluronic acid, propylene glycol hyaluronate, dimethylsilanol hyaluronate, and salts thereof.

3. An external composition described in claim 1 or 2, containing 1 to 30,000 parts by mass of (A) an ultraviolet protection agent per 1 part by mass of (D) hyaluronic acid derivative.

4. The topical composition according to claim 1 or 2, containing 0.0001 to 5000 parts by mass of the (D) component per 1 part by mass of the total content of the (B) component and the (C) component.

5. The topical composition described in claim 1 further contains one or more (E) nonionic surfactants selected from the group consisting of polyglycerin fatty acid esters, polyoxyethylene fatty acid esters, and polyether-modified silicones, the content of which is 2 mass% or less.