Compositions for cleansing removable dental prosthetics

Abstract

To provide an aqueous cleansing composition for dental prosthetics and orthodontic devices, and a method for removing microorganisms and stains from dental prosthetics and other orthodontic devices.SOLUTION: There is provided an aqueous cleansing composition, containing: hydrogen peroxide in an amount ranging from about 125 ppm to about 25% by weight; one or more carboxylic acids in an amount ranging from about 150 ppm to about 30% by weight; and one or more peracids in an amount ranging from about 100 ppm to about 20% by weight, wherein at least one of the peracids has the same number of carbons as one of the carboxylic acids.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present disclosure relates to cleaning compositions for eliminating microorganisms and removing stains from dental prostheses and orthodontic appliances. [Background technology]

[0002] Removable dental prostheses (dentures) and other oral dental appliances require regular and frequent cleaning to prevent diseases such as stomatitis and pneumonia. The acrylic and other polymer denture bases used in retainers and other removable orthodontic appliances are easily colonized by oral bacteria in the mucous membranes underneath and on the dentures. This microbial buildup can lead to denture-associated stomatitis and aspiration pneumonia, a life-threatening infection, especially for the elderly.

[0003] There is a need for better products for cleaning dental prostheses. Summary of the Invention

[0004] This patent document discloses cleaning compositions for eliminating microorganisms from dental prostheses, including, for example, dentures, caps, inlays, onlays, and bridges, as well as retainers and other removable orthodontic appliances. Compared to conventional products, the compositions described herein can eliminate microorganisms such as bacteria, viruses, and fungi, and can also remove biofilms, stains, and other contaminants. The cleaning process can be completed in a short time and leaves no obvious damage to the dental prostheses.

[0005] A first aspect of the present disclosure provides an aqueous cleaning composition containing hydrogen peroxide in an amount ranging from about 125 ppm to about 25% by weight, one or more carboxylic acids in an amount ranging from about 150 ppm to about 30% by weight, and one or more peracids in an amount ranging from about 100 ppm to about 20% by weight, at least one of the peracids having the same number of carbons as one of the carboxylic acids.

[0006] In one embodiment, the composition further comprises one or more C in the range of about 1.25 ppm to about 5% by weight. 1~5 Contains an alkyl hydroperoxide. In another embodiment, the carboxylic acid is acetic acid. In one embodiment, the amount of acetic acid is in the range of about 15% to about 20% by weight. In another embodiment, the amount of acetic acid is in the range of about 150 ppm to about 20% by weight.

[0007] In another embodiment, the amount of hydrogen peroxide ranges from about 125 ppm to about 20% by weight.In another embodiment, the amount of hydrogen peroxide ranges from about 5% to about 20% by weight.

[0008] In a further embodiment, the amount of the one or more carboxylic acids is in the range of about 150 ppm to 20% by weight. In a further embodiment, the amount of the one or more carboxylic acids is in the range of about 5% to 20% by weight. In yet a further embodiment, the one or more carboxylic acids are selected from C2-10 monocarboxylic acids, dicarboxylic acids, tricarboxylic acids, α-ketocarboxylic acids, β-ketocarboxylic acids, and mixtures thereof. In yet a further embodiment, the one or more carboxylic acids is acetic acid in an amount in the range of about 7% to about 20% by weight of the total weight of the composition.

[0009] In a different embodiment, the one or more carboxylic acids further include citric acid, succinic acid, glutathione, The oleic acid may contain one or more additional acids selected from the group consisting of lactic acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures of any of these.

[0010] In one embodiment, the peracid is peracetic acid. In another embodiment, the one or more peracids are in an amount of about 100 ppm to about 12% by total weight of the composition. In another embodiment, the one or more peracids are in an amount of about 6% to about 12% by total weight of the composition.

[0011] In another embodiment, the composition contains hydrogen peroxide in an amount ranging from about 5% to about 25% by weight, one or more carboxylic acids in an amount ranging from about 10% to about 30% by weight, and one or more peracids in an amount ranging from about 4% to about 20% by weight.

[0012] In yet another embodiment, the composition contains hydrogen peroxide in an amount in the range of about 5% to about 25% by weight, acetic acid in an amount in the range of about 5% to about 22% by weight, and peracetic acid in an amount in the range of about 0.25% to about 14% by weight.

[0013] In another embodiment, the aqueous cleaning composition contains hydrogen peroxide in an amount ranging from about 125 ppm to about 625 ppm, one or more carboxylic acids in an amount ranging from about 150 ppm to about 750 ppm, and one or more peracids in an amount ranging from about 100 ppm to about 500 ppm.

[0014] In another embodiment, the one or more carboxylic acids is acetic acid in an amount of about 375 ppm to about 500 ppm.In a further embodiment, the one or more peracids in the composition is peracetic acid in an amount of about 150 ppm to about 350 ppm.

[0015] In yet a further embodiment, the composition has a peracid concentration of about 125 ppm to 400 ppm. In yet a further embodiment, the composition is diluted with water to a peracid concentration of from about 100 ppm to about 25000 ppm.

[0016] In a further embodiment, the composition contains hydrogen peroxide in an amount in the range of about 125 to about 3 weight percent, one or more carboxylic acids in an amount in the range of about 150 to about 3 weight percent, and one or more peracids in an amount in the range of about 100 ppm to about 500 ppm, at least one of the peracids having the same number of carbons as one of the carboxylic acids.

[0017] In one embodiment, the composition contains hydrogen peroxide in an amount ranging from about 55,000 ppm to about 120,000 ppm, one or more carboxylic acids in an amount ranging from about 70,000 ppm to about 120,000 ppm, and one or more peracids in an amount ranging from about 6,500 ppm to about 22,000 ppm, at least one of the peracids having the same number of carbons as one of the carboxylic acids.

[0018] In another embodiment, the peracid concentration is from about 100 ppm to about 25000 ppm.In a further embodiment, the composition contains hydrogen peroxide in an amount ranging from about 5000 ppm to about 20000 ppm, one or more carboxylic acids in an amount ranging from about 5000 ppm to about 20000 ppm, and one or more peracids in an amount ranging from about 100 ppm to about 300 ppm, at least one of the peracids having the same number of carbons as one of the carboxylic acids.

[0019] Any of the compositions of the present invention have a microbial kill time of less than 5 minutes. In another embodiment, the composition of any of the aspects of the invention contains one or more carboxylic acids selected from the group consisting of C2-10 monocarboxylic acids, dicarboxylic acids, tricarboxylic acids, α-ketocarboxylic acids, β-ketocarboxylic acids, and mixtures thereof. In some embodiments, the compositions of any aspect of the invention contain one or more carboxylic acids and one or more additional acids selected from citric acid, succinic acid, glutaric acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures of any of these.

[0020] In a further embodiment, the composition is in a form selected from a solution, a gel, or a foam. In yet a further embodiment, the composition of any aspect of the present invention further comprises a stabilizer. In yet a further embodiment, the stabilizer is selected from etidronic acid, dipicolinic acid, and dipicolinic acid N-oxide. In a different embodiment, the composition of any aspect of the present invention further comprises a grinding aid. In one embodiment, the grinding aid is selected from calcium carbonate, silica gel, precipitated silica, silicate, alumina, phosphate, phosphate salt, hydrated aluminum oxide, magnesium carbonate, and combinations thereof.

[0021] A second aspect of the present invention provides a method for cleaning dental prostheses and removable orthodontic appliances by contacting the dental prosthesis or removable orthodontic appliance with any of the compositions described herein. In one embodiment, a diluted composition described herein is contacted with the dental prosthesis or removable orthodontic appliance by applying a pressurized solution of the composition to the surface of the dental prosthesis or removable orthodontic appliance. In another embodiment, the composition is contacted with the dental prosthesis or removable orthodontic appliance by immersing the surface of the dental prosthesis or removable orthodontic appliance in a solution of one of the compositions described herein.

[0022] In further embodiments of the methods disclosed herein, the composition contains hydrogen peroxide in an amount ranging from about 7% to about 25% by weight, acetic acid in an amount ranging from about 7% to about 22% by weight, and peracetic acid in an amount ranging from about 0.1% to about 14% by weight.

[0023] In a further embodiment of the disclosed method, the composition has a peracid concentration of from about 100 ppm to about 25,000 ppm. In yet a further embodiment, the diluted composition used in the described methods has a hydrogen peroxide concentration in the range of about 5000 ppm to about 20000 ppm, a carboxylic acid concentration in the range of about 5000 ppm to about 20000 ppm, and a peracid concentration in the range of about 100 ppm to about 300 ppm.

[0024] In yet further embodiments, the diluted compositions used in the described methods have a hydrogen peroxide concentration in the range of about 125 ppm to about 20,000 ppm, a carboxylic acid concentration in the range of about 150 ppm to about 20,000 ppm, and a peracid concentration in the range of about 100 ppm to about 300 ppm. In still further embodiments, the dental prosthesis or removable orthodontic appliance is soiled by contact with food or beverages.

[0025] The fifth aspect of the present invention provides a solid product for cleaning dental prostheses or removable orthodontic appliances, which is produced by removing water from the aqueous composition of the present invention. According to one embodiment, the composition is a solid powder that is essentially the same relative ratio after removing water. In another embodiment, the solid powder contains a magnesium salt of a carboxylic acid. [Brief description of the drawings]

[0026] [Figure 1] FIG. 1 is a photograph of wine-stained dentures and an unstained control prior to cleaning with a composition according to the invention. [Diagram 2] FIG. 2 is a photograph of the same wine-stained dentures and controls after cleaning. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0027] Various embodiments of the present document provide an aqueous cleaning composition for eliminating bacteria, fungi, mycobacteria, and spores from dental prostheses. The composition has been shown to prevent and / or destroy biofilms, thereby killing all microorganisms present in the biofilm on the surface in a short time. An additional advantage compared to conventional methods is the minimal impact on the appearance and durability of the dental prosthesis.

[0028] Some examples of the present disclosure are described in more detail below with reference to exemplary embodiments. Indeed, various aspects of the present disclosure can be embodied in many different forms and should not be construed as being limited to the examples set forth herein. Rather, these examples are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

[0029] The articles "a" and "an" are used herein, unless otherwise indicated, to mean "one or more" or "at least one." That is, the reference of any element or component of an embodiment by the indefinite article "a" or "an" does not exclude the possibility that more than one of the element or component is present.

[0030] The term "about" as used herein means a reference numerical designation, plus or minus 10% of the reference numerical designation. "C 1~5 The term "alkyl" as used herein means a straight or branched chain alkyl group having 1, 2, 3, 4, or 5 carbons. 1~10 The term "alkyl" as used herein means a straight or branched chain alkyl group having a number ranging from 1 to 10 carbons.

[0031] The term "peracid" as used herein means an oxidized form of a base organic acid, typically a carboxylic acid. Specifically, a peracid has a -(C=O)OOH group that is derived from the -(C=O)OH of the carboxylic acid.

[0032] The term "alkyl hydroperoxide" refers to a structure based on the structure of the corresponding alkane in which a hydrogen has been replaced with OOH. An embodiment of this patent document provides an aqueous composition for cleaning dental prostheses. The composition includes hydrogen peroxide in the range of about 125 ppm to about 25% by weight, one or more carboxylic acids in the range of about 150 ppm to about 30% by weight, and one or more peracids in the range of about 100 ppm to about 20% by weight. The composition also includes one or more C 1~5 The composition may contain an alkyl hydroperoxide. The composition may be in any suitable form, including, for example, a solution, a foam, or a gel. In some embodiments, the composition is an aqueous solution. Additional organic solvents may be added to improve the solubility of the components, the stability, and / or the effectiveness of the composition.

[0033] Compositions according to the invention may be prepared by conventional methods known to those skilled in the art. For example, 30% by weight hydrogen peroxide may be reacted and equilibrated with the desired carboxylic acid or its salt or anhydride. Group II carboxylate salts, particularly magnesium salts, may be used to produce compositions that can be recovered as solid powders by conventional means. The solid products contain essentially the same ratios of ingredients as contained in the liquid products, with the water removed, except that the magnesium-based solids have higher levels of organic acids, lower levels of peracids, and significantly lower levels of hydrogen peroxide.

[0034] As previously mentioned, the composition contains hydrogen peroxide. The amount of hydrogen peroxide disclosed herein is expressed as a pure substance value, not the amount of hydrogen peroxide in solution. It is understood that the water in the aqueous composition includes water obtained from the aqueous hydrogen peroxide solution used to prepare the composition. It should be noted that any suitable aqueous hydrogen peroxide solution may be used in the composition, such as an aqueous solution containing up to 30% or up to 50% hydrogen peroxide by weight. Depending on the desired end product, higher or lower hydrogen peroxide concentrations in the composition may be used. With an acid anhydride, lower hydrogen peroxide concentrations may be used. The ratio of starting materials is selected to provide the desired ratio of hydrogen peroxide, carboxylic acid, and peracid in the end product. Tetraacetylethylenediamine (TAED) may be reacted with hydrogen peroxide to produce the peracetic acid composition of the present invention.

[0035] According to one embodiment, the composition contains hydrogen peroxide in the range of about 5% to about 25% by weight, acetic acid in the range of about 5% to about 22% by weight, and peracetic acid in the range of about 0.5% to about 14% by weight.

[0036] The individual components in the composition are adjusted to ensure effectiveness in eliminating undesirable microorganisms and maintaining the quality of dental prostheses. In some embodiments, the hydrogen peroxide is in the range of about 5% to about 25%, about 7% to about 20%, about 7% to about 18%, or about 7% to about 12%, all by weight.

[0037] Carboxylic acids are C 2~10 The carboxylic acid may be a monocarboxylic acid, a dicarboxylic acid, a tricarboxylic acid, an α-keto carboxylic acid, a β-keto carboxylic acid, or a mixture thereof. Non-limiting examples of carboxylic acids include acetic acid, propionic acid, citric acid, succinic acid, glutaric acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures thereof.

[0038] In some embodiments, the one or more carboxylic acids, individually or collectively, are in the range of about 5% to about 30%, about 5% to about 25%, about 5% to about 22%, about 5% to about 20%, about 7% to about 18%, or about 10% to 30%, all by weight of the composition.

[0039] In some embodiments, the composition contains acetic acid in the range of about 5% to about 25%, about 5% to about 22%, about 5% to about 20%, about 4% to about 20%, or about 7% to about 19% by weight of the total composition. In some embodiments, the composition further contains one or more additional acids selected from citric acid, succinic acid, glutaric acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures of any of these.

[0040] In some embodiments, the one or more additional acids, when present, are individually and independently from about 0.001% to about 0.2% by weight, from about 0.001% to about 0.15% by weight, from about 0.002% to about 0.15% by weight, from about 0.02% to about 0.15% by weight, from about 0.02% to about 0.10% by weight, from about 0.05% to about 0.1% by weight, from about 0.06% to about 0.08% by weight, from about 0.07% to about 0.08% by weight, from about 0.002% to about 0.02% by weight, The range is about 0.003% by weight to about 0.015% by weight, about 0.004% by weight to about 0.015% by weight, about 0.010% by weight to about 0.02% by weight, about 0.010% by weight to about 0.015% by weight, about 0.010% by weight to about 0.013% by weight, about 0.011% by weight to about 0.013% by weight, about 0.003% by weight to about 0.02% by weight, about 0.003% by weight to about 0.01% by weight, about 0.003% by weight to about 0.008% by weight, or about 0.004% by weight to about 0.006% by weight.

[0041] The amount of peracid is adjusted to a suitable range to achieve the desired effect in combination with the carboxylic acid, in some embodiments, the peracid ranges from about 0.1% to about 20%, from about 0.25% to about 14%, from about 0.5% to about 12%, from about 0.75% to about 10%, or from about 1% to about 10%, all by weight of the composition.

[0042] In some embodiments, the peracid has the same number of carbons as one of the carboxylic acids. In some embodiments, the peracid is peracetic acid. In some embodiments, the composition comprises acetic acid and peracetic acid.

[0043] The composition also comprises C 1~5 It also contains an alkyl hydroperoxide, which may be, for example, methyl hydroperoxide, ethyl hydroperoxide, propyl hydroperoxide, or any combination thereof. 1~5 The alkyl hydroperoxide is in the range of about 1.25 ppm by weight to about 5% by weight, about 0.05% by weight to about 5% by weight, about 0.1% by weight to about 5% by weight, about 0.1% by weight to about 2% by weight, about 0.1% by weight to about 1% by weight, about 0.2% by weight to about 2% by weight, about 0.2% by weight to about 1% by weight, about 0.3% by weight to about 1% by weight, about 0.2% by weight to about 0.8% by weight, about 0.3% by weight to about 0.6% by weight, or about 0.4% by weight to about 0.6% by weight.

[0044] In some embodiments, the composition also comprises in the range of about 0.05% to about 2% by weight of a geminal dihydroperoxy-substituted C 3~10 Carboxylic acids are also included. Geminal dihydroperoxy substituted C 3~10 Non-limiting examples of carboxylic acids include 3,3-bis(hydroperoxybutanoic acid, and 3,3-bis(hydroperoxy)pentanoic acid. Further exemplary ranges of acids include about 0.05% to about 1% by weight, about 0.05% to about 0.5% by weight, about 0.05% to about 0.8% by weight, about 0.05% to about 0.5% by weight, about 0.1% to about 0.3% by weight, or about 0.1% to about 0.2% by weight. In some embodiments, the composition also contains geminal dihydroperoxy substituted C 3~10 Also includes alkyl. Geminal dihydroperoxy substituted C 3~10 Non-limiting examples of alkyl include 2,2-bis(hydroperoxy)propane, 2,2-bis(hydroperoxy)butane, and 2,2-bis(hydroperoxy)pentane. In some embodiments, geminal dihydroperoxy-substituted C 3~10The alkyl is in the range of about 0.005% to about 0.2% by weight, about 0.005% to about 0.1% by weight, about 0.01% to about 0.2% by weight, about 0.01% to about 0.1% by weight, about 0.01% to about 0.05% by weight, about 0.01% to about 0.03% by weight, or about 0.02% to about 0.03% by weight.

[0045] In some embodiments, the composition includes a stabilizer. Any suitable stabilizer may be used, such as an acid such as etidronic acid, dipicolinic acid, or dipicolinic acid N-oxide. The stabilizer may be present in an amount ranging from about 0.003% to about 0.05% by weight, from about 0.003% to about 0.03% by weight, from about 0.005% to about 0.05% by weight, from about 0.008% to about 0.05% by weight, from about 0.008% to about 0.02% by weight, from about 0.008% to about 0.01% by weight, or from about 0.008% to about 0.015% by weight.

[0046] In some embodiments, the composition includes a grinding aid that can contribute to the cleaning ability of the composition without causing damage to dental prostheses.Any suitable grinding aid may be used, such as calcium carbonate, silica gel, precipitated silica, silicate, alumina, phosphate, phosphate salt, hydrated aluminum oxide, magnesium carbonate, or a combination thereof.Specific examples include dicalcium orthophosphate dihydrate, calcium pyrophosphate, calcium phosphate, hydrated alumina, beta calcium pyrophosphate, and resin-based abrasives.

[0047] Another aspect of this document includes a method for cleaning a dental prosthesis. The method is effective for removing or destroying sludge, biofilm, bacteria, stains, and other contaminants from the dental prosthesis. The method generally includes contacting the dental prosthesis with a cleaning composition. When used as a solution, the peracid concentration of the composition is adjusted depending on the pathogen or contaminant to be removed. Typical peracid concentrations in the water-diluted solution are in the range of about 50 to about 25,000 ppm. According to one embodiment, the peracid concentration is about 100 ppm to about 23,000 ppm.

[0048] According to one embodiment, the peracid concentration is about 6500 ppm to about 23000 ppm. According to one embodiment, the peracid concentration is about 6500 ppm to about 11500 ppm. According to one embodiment, the peracid concentration is about 13000 ppm to about 22000 ppm.

[0049] According to one embodiment, the peracid concentration is about 1500 ppm to about 15000 ppm. According to one embodiment, the peracid concentration is about 2500 ppm to about 10000 ppm. According to another embodiment, the peracid concentration is about 3000 to about 8000 ppm.

[0050] According to one embodiment, the peracid concentration is about 50 ppm to about 3000 ppm. According to one embodiment, the peracid concentration is about 70 ppm to about 2500 ppm. According to one embodiment, the peracid concentration is about 90 ppm to about 1500 ppm. According to one embodiment, the peracid concentration is about 100 ppm to about 1000 ppm.

[0051] According to one embodiment, the peracid concentration is less than 5000 ppm. According to one embodiment, the peracid concentration is less than 2500 ppm. According to one embodiment, the peracid concentration is less than 1000 ppm. According to one embodiment, the peracid concentration is less than 750 ppm.

[0052] The composition may be highly diluted such that the diluted composition has a peracid concentration of less than 500 ppm. According to one embodiment, the peracid concentration is from about 100 ppm to about 500 ppm. According to one embodiment, the peracid concentration is from about 100 ppm to about 300 ppm. According to one embodiment, the peracid concentration is from about 125 ppm to about 400 ppm. According to one embodiment, the peracid concentration is from about 150 ppm to about 300 ppm. According to one embodiment, the peracid concentration is from about 150 ppm to about 350 ppm.

[0053] According to one embodiment, the peracid concentration is less than 500 ppm. According to one embodiment, the peracid concentration is less than 250 ppm. According to one embodiment, the peracid concentration is less than 100 ppm.

[0054] In one embodiment, the highly diluted composition may contain from about 5,000 ppm to about 20,000 ppm of hydrogen peroxide. In one embodiment, the highly diluted composition may contain from about 5,000 ppm to about 20,000 ppm of carboxylic acid.

[0055] In one embodiment, the diluted cleaning composition may contain hydrogen peroxide in an amount ranging from about 5,000 ppm to about 20,000 ppm, one or more carboxylic acids in an amount ranging from about 5,000 ppm to about 20,000 ppm, and one or more peracids in an amount ranging from about 100 ppm to about 300 ppm.

[0056] In another embodiment, the aqueous cleaning composition contains hydrogen peroxide in an amount ranging from about 125 ppm to about 625 ppm, one or more carboxylic acids in an amount ranging from about 150 ppm to about 750 ppm, and one or more peracids in an amount ranging from about 100 ppm to about 500 ppm.

[0057] In one embodiment, the concentration of the carboxylic acid in the diluted composition may be less than 20000 ppm. According to one embodiment, the concentration of the carboxylic acid may be less than 15000 ppm. According to one embodiment, the concentration of the carboxylic acid may be less than 1000 ppm. According to one embodiment, the carboxylic acid concentration is from about 5000 ppm to about 20000 ppm.

[0058] According to one embodiment, the carboxylic acid concentration is about 250 ppm to about 750 ppm. According to one embodiment, the carboxylic acid concentration is about 300 ppm to about 650 ppm. According to one embodiment, the carboxylic acid concentration is about 350 ppm to about 600 ppm.

[0059] According to one embodiment, the carboxylic acid concentration is about 300 ppm to about 550 ppm. According to one embodiment, the carboxylic acid concentration is less than 750 ppm. According to one embodiment, the carboxylic acid concentration is less than 650 ppm. According to one embodiment, the carboxylic acid concentration is less than 500 ppm.

[0060] In one embodiment, the concentration of hydrogen peroxide may be less than 700 ppm. According to one embodiment, the hydrogen peroxide concentration is about 125 ppm to about 625 ppm. According to one embodiment, the hydrogen peroxide concentration is about 135 ppm to about 550 ppm. According to one embodiment, the hydrogen peroxide concentration is about 145 ppm to about 450 ppm. According to one embodiment, the hydrogen peroxide concentration is about 150 ppm to about 350 ppm.

[0061] According to one embodiment, the hydrogen peroxide concentration is less than 625 ppm. According to one embodiment, the hydrogen peroxide concentration is less than 550 ppm. According to one embodiment, the hydrogen peroxide concentration is less than 400 ppm.

[0062] The diluted composition may have a microbial kill time of less than about 5 minutes. In one embodiment, the diluted composition contains one or more carboxylic acids selected from C2-10 monocarboxylic acids, dicarboxylic acids, tricarboxylic acids, α-ketocarboxylic acids, β-ketocarboxylic acids, and mixtures thereof. In another embodiment, the diluted composition further contains one or more additional acids selected from propionic acid, citric acid, succinic acid, glutaric acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures of any of these. In one embodiment, the carboxylic acid may include acetic acid in an amount of about 375 ppm to about 500 ppm.

[0063] In one embodiment, the peracid in the composition is peracetic acid in an amount of about 150 ppm to about 350 ppm. In another embodiment, the diluted composition further contains one or more C1-5 alkyl hydroperoxides in an amount ranging from about 1.25 ppm to about 125 ppm.

[0064] Another aspect of the invention includes a method for cleaning dental prostheses and removable orthodontic appliances comprising contacting the dental prosthesis or removable orthodontic appliance with a diluted composition. In some embodiments, the contact time is less than about 45 minutes, less than about 30 minutes, less than about 20 minutes, less than about 15 minutes, less than about 10 minutes, less than about 5 minutes, or less than about 1 minute. The contact time can be a length of time that is effective for removing biofilm and / or killing microorganisms. Contact may be accomplished by spraying a solution of the composition onto the dental prosthesis, for example, using a water pick that applies the solution at high pressure. Alternatively, the dental prosthesis may be immersed in the solution. If desired, a step of brushing or scrubbing the surface of the dental prosthesis may be added. Sonication is also a step that may be performed as desired to facilitate the cleaning process. Thus, the ability of the compositions described herein to disinfect dental prostheses by removing biofilm and by killing microorganisms such as yeast, viruses, and bacteria may be useful in treating diseases and conditions including, for example, gingivitis, stomatitis, and cheilitis. This effectively reduces the user's risk of exposure to the situation.

[0065] Working Example Example 1 An experiment was conducted in which contaminated dentures were treated with a composition of the present invention, identified as Formula I, using a water flosser. Formula I was an aqueous solution containing 19.6% by weight hydrogen peroxide, 16.8% by weight acetic acid, 10.3% by weight peracetic acid, and less than 0.3% by weight other carboxylic acids. All extracted microorganisms were identified (Table 1), and the average kill rate for the four dentures was 99.9992 percent after 15 minutes of treatment (Table 2A (control) and Table 2B (treated with Formula I)).

[0066] [Table 1]

[0067] [Table 2]

[0068] Additionally, when denture treatment with the composition of the present invention was compared to treatment with a commercially available cleaner, it was clearly demonstrated that the current commercially available cleaner had a lower bacterial kill rate compared to the present invention (Tables 3 and 4).

[0069] [Table 3]

[0070] [Table 4]

[0071] To test for any adverse effects of the composition on the denture, one denture was cut in half. One half was exposed to a water control and the other half was exposed to a solution of 8000 ppm of Formulation I for 32 periods of 15 minutes. No visible differences were observed between the two halves after treatment.

[0072] A bleaching experiment was initiated to determine whether the composition would remove wine stains from dentures. A clean denture was cut in half and one half was stained with wine. The wine-stained half was exposed to a solution of Formula I 10 times for 15 minutes, which removed all stains without any obvious damage to the denture. The results are shown in Figures 1 and 2.

[0073] Example 2 The compositions set forth in Table 5 were used to study the time to kill pathogens. The time to kill selected microorganisms was determined and recorded in Table 6.

[0074] [Table 5]

[0075] [Table 6]

[0076] Many modifications and other examples of the disclosure set forth herein will come to mind to one skilled in the art to which this disclosure pertains having the benefit of the teachings presented in the foregoing descriptions and the associated drawings. It is to be understood, therefore, that the disclosure is not to be limited to the specific examples disclosed, and that modifications and other embodiments are intended to be included within the scope of the appended claims.

[0077] Moreover, while the above description and related embodiments describe aspects of the disclosure with respect to certain example combinations of structural elements and / or functions, it should be understood that different combinations of elements and / or functions may be provided by alternative embodiments without departing from the scope of the appended claims. In this regard, for example, it is contemplated that combinations of elements and / or functions other than those expressly described above may be set forth in any of the appended claims. Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. Hydrogen peroxide in an amount ranging from about 125 ppm by weight to about 25% by weight; one or more carboxylic acids in an amount ranging from about 150 ppm by weight to about 30% by weight, and One or more peracids in an amount ranging from about 100 ppm by weight to about 20% by weight; wherein at least one of the peracids has the same number of carbons as one of the carboxylic acids.

2. One or more C in the range of about 1.25 ppm by weight to about 5% by weight １～５ The cleaning composition of claim 1 further comprising an alkyl hydroperoxide.

3. 2. The composition of claim 1, wherein the hydrogen peroxide is in the range of about 125 ppm to about 20% by weight.

4. The composition of claim 1, wherein the hydrogen peroxide is in the range of about 10% to about 20% by weight.

5. 2. The composition of claim 1, wherein the one or more carboxylic acids is in the range of about 150 ppm to 20% by weight.

6. The composition of claim 1, wherein the one or more carboxylic acids is in the range of about 12% to 20% by weight.

7. The one or more carboxylic acids are ２～１０ 2. The composition of claim 1, wherein the fatty acid is selected from the group consisting of fatty acids, dicarboxylic acids, tricarboxylic acids, α-ketocarboxylic acids, β-ketocarboxylic acids, and mixtures thereof.

8. 2. The composition of claim 1, wherein the one or more carboxylic acids comprises acetic acid in the range of about 150 ppm to 20% of the total weight of the composition.

9. The composition of claim 1 , wherein the one or more carboxylic acids comprises acetic acid in the range of about 15% to about 20% of the total weight of the composition.

10. 9. The composition of claim 8, wherein the one or more carboxylic acids further comprise one or more additional acids selected from the group consisting of propionic acid, citric acid, succinic acid, glutaric acid, adipic acid, suberic acid, malonic acid, lactic acid, glycolic acid, oxalic acid, pyruvic acid, citramalic acid, acetoacetic acid, citraconic acid, maleic acid, and mixtures of any thereof.

11. 10. The composition of claim 1, wherein the one or more peracids are in the range of about 100 ppm to about 12% of the total weight of the composition.

12. 10. The composition of claim 1, wherein the one or more peracids are in the range of about 6% to about 12% of the total weight of the composition.

13. 10. The composition of claim 1, wherein the peracid is peracetic acid in an amount ranging from about 100 ppm to about 12% of the total weight of the composition.

14. The composition of claim 1, wherein the peracid is peracetic acid in an amount ranging from about 6% to about 12% by total weight of the composition.

15. the hydrogen peroxide is in the range of about 5% to about 25% by weight; the one or more carboxylic acids are in the range of about 10% to about 30% by weight; and the one or more peracids are in the range of about 4% to about 20% by weight; 2. The composition of claim 1, wherein at least one of the peracids has the same number of carbons as one of the carboxylic acids.

16. the hydrogen peroxide is in the range of about 5% to about 25% by weight; the carboxylic acid comprises acetic acid in an amount ranging from about 5% to about 22% by weight; and the peracid comprising peracetic acid in an amount ranging from about 0.25% to about 14% by weight; The composition of claim 1.

17. the hydrogen peroxide is in the range of about 125 ppm to about 625 ppm; the one or more carboxylic acids are in the range of about 150 ppm to about 750 ppm, and the one or more peracids are in the range of about 100 ppm to about 500 ppm; The composition of claim 1.

18. 10. The composition of claim 1, wherein the one or more carboxylic acids comprises acetic acid in an amount from about 375 ppm to about 500 ppm.

19. 10. The composition of claim 1, wherein the one or more peracids is peracetic acid in an amount from about 150 ppm to about 350 ppm.

20. 10. The composition of claim 1, wherein the composition has a peracid concentration of about 125 ppm to 400 ppm.

21. the hydrogen peroxide is in the range of about 125% to about 3% by weight; the one or more carboxylic acids are in the range of about 150% to about 3% by weight; and the one or more peracids are in the range of about 100 ppm to about 500 ppm; 2. The composition of claim 1, wherein at least one of the peracids has the same number of carbons as one of the carboxylic acids.

22. the hydrogen peroxide is in the range of about 55,000 ppm to about 120,000 ppm; the one or more carboxylic acids are in the range of about 70,000 ppm to about 120,000 ppm; and the one or more peracids are in the range of about 6500 ppm to about 22000 ppm; The composition of claim 1.

23. 2. The composition of claim 1, wherein the peracid concentration is from about 100 ppm to about 25,000 ppm.

24. the hydrogen peroxide is in the range of about 5,000 ppm to about 20,000 ppm; the one or more carboxylic acids are in the range of about 5,000 ppm to about 20,000 ppm; and the one or more peracids are in the range of about 100 ppm to about 300 ppm; 2. The composition of claim 1, wherein at least one of the peracids has the same number of carbons as one of the carboxylic acids.

25. 10. The composition of claim 1, in a form selected from the group consisting of a solution, a gel, or a foam.

26. The composition of claim 1 further comprising a stabilizer.

27. 27. The composition of claim 26, wherein the stabilizer is selected from the group consisting of etidronic acid, dipicolinic acid, and dipicolinic acid N-oxide.

28. The composition of claim 1 further comprising a grinding aid.

29. 30. The composition of claim 28, wherein the grinding aid is selected from the group consisting of calcium carbonate, silica gel, precipitated silica, silicates, aluminas, phosphates, phosphoric acid salts, hydrated aluminum oxide, magnesium carbonate, and combinations thereof.

30. 13. A method for cleaning dental prostheses and removable orthodontic appliances comprising contacting the dental prosthesis or removable orthodontic appliance with the composition of claim 1.

31. 31. The method of claim 30, wherein the composition is contacted with the dental prosthesis or removable orthodontic appliance by applying a pressurized solution of the composition to a surface of the dental prosthesis or removable orthodontic appliance.

32. 31. The method of claim 30, wherein the composition is contacted with the dental prosthesis or removable orthodontic appliance by immersing a surface of the dental prosthesis or removable orthodontic appliance in a solution of the composition.

33. 31. The method of claim 30, wherein the composition has a peracid concentration of about 100 ppm to 25,000 ppm.

34. The composition, a hydrogen peroxide concentration in the range of about 5000 ppm to about 20000 ppm; a carboxylic acid concentration in the range of about 5000 ppm to about 20000 ppm; and a peracid concentration in the range of about 100 ppm to about 300 ppm; 31. The method of claim 30, having the following structure:

35. The composition, a hydrogen peroxide concentration in the range of about 125 ppm to about 20,000 ppm; a carboxylic acid concentration in the range of about 150 ppm to about 20,000 ppm; and a peracid concentration in the range of about 100 ppm to about 300 ppm; 31. The method of claim 30, having the following structure:

36. 31. The method of claim 30, wherein the dental prosthesis or removable orthodontic appliance is soiled by contact with food or beverage items.

37. 13. A solid product for cleaning a dental prosthesis or removable orthodontic appliance, said solid product being formed by removing water from the aqueous composition of claim 1.

38. 38. The solid product of claim 37, further comprising a magnesium salt of the carboxylic acid.

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