Alcohol disinfectant composition for skin

Abstract

To provide an alcohol disinfectant composition for skin characterized by superior antibacterial durability, reduced skin irritation, and effective prevention of hand roughness.SOLUTION: An alcohol disinfectant composition for skin contains component (A): ethanol and / or isopropanol, component (B): a polyol satisfying (OH group count / C atom count)<1, and component (C): at least one acid selected from the group consisting of lactic acid, pyruvic acid and urocanic acid or a salt thereof, where the content of component (A) is 40 mass% or more and 95 mass% or less, the content of component (B) is 2.5 mass% or more and 10 mass% or less, the content of component (C) is 0.10 mass% or more and 2.0 mass% or less, and the pH at 25°C is 4.0 or more and 6.5 or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an alcohol-based disinfectant composition for skin. [Background technology]

[0002] According to recent surveys, it is now known that contact infection is the most common route of bacterial or viral infection in people's daily lives, public facilities, and medical and nursing care facilities. Contact infection occurs mainly when hands come into contact with infected people, doorknobs, handles, tableware, toys, other daily necessities, interior items, etc.

[0003] As a method for preventing contact infection of bacteria or viruses through hands, a method of applying an alcohol-based disinfectant or the like to hands to sterilize and disinfect them is known.

[0004] For example, Patent Document 1 describes the following components (A), (B) and (C): (A): 40 to 95% by mass of ethanol and / or isopropanol (B): Water-soluble polyhydric alcohol 0.2 to 3% by mass (C): Fatty acid triglyceride 0.01 to 0.15% by mass A hand sanitizer composition comprising: Patent Document 2 discloses a leave-on skin topical preparation composition that contains (A) one or more acids or salts thereof selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid, and (B) a nonionic surfactant having a lipophilic group with 12 carbon atoms and an HLB of 8.0 or more and 17.0 or less, in which the content of component (A) is 0.02% by mass or more and 20.0% by mass or less, the content of component (B) is 0.006% by mass or more and 5.0% by mass or less, and the pH is 3.5 or more and 5.0 or less. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2011-219410 A [Patent Document 2] Patent Publication No. 2022-33040 Summary of the Invention [Problem to be solved by the invention]

[0006] However, alcohol-based disinfectants are highly volatile and do not provide sufficient durability in terms of providing bactericidal and virucidal effects to hands and fingers. In addition, there is a problem in that the protein denaturing effect of alcohol can cause rough hands. In Patent Document 1, the effect of suppressing rough hands of a composition containing alcohol such as ethanol is examined, but there is room for improvement in terms of achieving both antibacterial durability and the effect of suppressing rough hands. In addition, in Patent Document 2, the bactericidal or virucidal activity of a composition that does not actively contain alcohol such as ethanol is examined, but there is room for improvement in terms of achieving both antibacterial durability and the effect of suppressing rough hands of a composition that contains alcohol such as ethanol as an essential component.

[0007] Therefore, an object of the present invention is to provide an alcohol disinfectant composition for skin which has excellent antibacterial durability, is less irritating to the skin, and has an excellent effect of suppressing rough hands. [Means for solving the problem]

[0008] The present inventors have discovered that an alcohol-based disinfectant composition for skin containing specific amounts of a specific polyol and a specific acid or its salt and having a specific pH range can solve the above problems. That is, the present invention provides Component (A): ethanol and / or isopropanol, Component (B): A polyol satisfying the formula (number of OH groups / number of C atoms) < 1, and Component (C): one or more acids or salts thereof selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid An alcohol-based disinfectant composition for skin comprising: The content of component (A) is 40% by mass or more and 95% by mass or less, The content of component (B) is 2.5% by mass or more and 10% by mass or less, The content of component (C) is 0.10% by mass or more and 2.0% by mass or less, The present invention relates to an alcohol disinfectant composition for skin, which has a pH of 4.0 or more and 6.5 or less at 25°C. Effect of the Invention

[0009] According to the present invention, it is possible to provide an alcohol disinfectant composition for skin which has excellent antibacterial durability, is less irritating to the skin, and is also effective in inhibiting rough hands. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] [Definition] In this specification, "antibacterial" includes both the meaning of an action to kill bacteria and the meaning of an action to suppress the growth of bacteria without killing them. In addition, "antibacterial sustained" means that the composition shows antibacterial activity even after a certain period of time has elapsed after application to the skin.

[0011] [Alcohol-based disinfectant composition for skin] The alcohol disinfectant composition for skin of the present invention (hereinafter also simply referred to as the "composition of the present invention") is Component (A): ethanol and / or isopropanol, Component (B): A polyol satisfying the formula (number of OH groups / number of C atoms) < 1, and Component (C): one or more acids or salts thereof selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid An alcohol-based disinfectant composition for skin comprising: The content of the component (A) is 40% by mass or more and 95% by mass or less, The content of the component (B) is 2.5% by mass or more and 10% by mass or less, The content of the component (C) is 0.10% by mass or more and 2.0% by mass or less, The pH at 25°C is 4.0 or higher and 6.5 or lower.

[0012] The present invention has the effect of providing an alcohol disinfectant composition for skin that has excellent antibacterial durability, is less irritating to the skin, and is also effective in inhibiting rough hands. The reason for this is not entirely clear, but is thought to be as follows. Although component (A) has antibacterial activity, it is known that it is highly volatile when used alone and highly irritating to the skin. Component (B) is a polyol that satisfies (number of OH groups / number of C atoms) < 1, and has a hydrophilic part containing a hydroxyl group and a hydrophobic part containing a C atom. It is believed that the hydrophobic part of the polyol exerts antibacterial activity by distorting or destroying the three-dimensional hydrogen bond network of water. On the other hand, it is believed that the hydrophilic part of the polyol has high affinity with water molecules and can reduce irritation to the skin. Furthermore, component (B) has the property of being less volatile than component (A). Component (C) is one or more acids selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid, or salts thereof. Component (C) has antibacterial activity, but is also a component that is naturally present on human skin, for example, by being supplied from sweat glands, and is therefore thought to be able to reduce irritation to the skin. It is believed that when the composition contains a specific combination of components (A), (B), and (C) in specific amounts and the pH is adjusted to a specific range, the above-mentioned mechanism of action improves the durability of the antibacterial effect and the effect of inhibiting rough hands.

[0013] The bacteria against which the composition of the present invention exerts its antibacterial properties are not particularly limited, so long as they are inactivated or killed by contact with the composition. For example, microorganisms listed in the Ministry of Health, Labor and Welfare's guidelines for infectious disease control in daycare centers can be applied. Specific examples of bacteria include gram-positive bacteria such as Bacillus anthracis, Mycobacterium tuberculosis, Streptococcus pyogenes, Staphylococcus aureus, and Streptococcus pneumoniae, and gram-negative bacteria such as Serratia marcescens, Francisella tularensis, Yersinia pestis, Brucella, Bacillus mallei, Vibrio cholerae, Salmonella, Shigella, Escherichia coli, and Bordetella pertussis. In this example, the antibacterial properties are evaluated using Serratia marcescens as an example, but the bacteria that can be disinfected by the composition of the present invention are not limited to this.

[0014] The composition of the present invention can be used not only against bacteria but also against viruses, such as enveloped viruses, arenaviruses, Ebola viruses, smallpox viruses, Nairo viruses, Marburg viruses, coronaviruses, monkeypox viruses, betacoronaviruses, influenza viruses, RS viruses, herpes viruses, mumps viruses, varicella-zoster viruses, rubella viruses, and measles viruses, and non-enveloped viruses, such as enteroviruses, adenoviruses, coxsackie viruses, noroviruses, and rotaviruses.

[0015] <Component (A)> The composition of the present invention contains ethanol and / or isopropanol as component (A), which acts as an antibacterial component.

[0016] The content of the component (A) in the composition of the present invention is, from the viewpoint of bactericidal and antibacterial activity, 40 mass% or more, preferably 45 mass% or more, more preferably 50 mass% or more, even more preferably 52 mass% or more, and is 95 mass% or less, preferably 90 mass% or less, more preferably 85 mass% or less, even more preferably 80 mass% or less, still more preferably 70 mass% or less, still more preferably 65 mass% or less, and even more preferably 60 mass% or less. When ethanol and isopropanol are used in combination, the mixing ratio of ethanol / isopropanol (mass ratio) is preferably 50 / 50 to 99 / 1, and more preferably 80 / 20 to 99 / 1.

[0017] <Ingredient (B)> The composition of the present invention contains, as component (B), a polyol that satisfies the ratio (number of OH groups / number of C atoms) < 1. From the viewpoints of reducing irritation to the skin and suppressing rough hands, and improving antibacterial activity and its sustained effect, component (B) preferably contains a polyol (b-1) having a ratio (number of OH groups / number of C atoms) of more than 0.45 and a polyol (b-2) having a ratio (number of OH groups / number of C atoms) of 0.45 or less. Polyol (b-1) not only reduces irritation to the skin and helps prevent rough hands, but also, when present together with polyol (b-2), suppresses the volatilization of polyol (b-2), which is an antibacterial component, and can contribute to improving the antibacterial activity of polyol (b-2) and its sustained effect.

[0018] (Polyol (b-1)) The (number of OH groups / number of C atoms) of the polyol (b-1) is more than 0.45, preferably 0.46 or more, more preferably 0.47 or more, even more preferably 0.48 or more, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of the polyol (b-2), which is an antibacterial component, and is less than 1, more preferably 0.9 or less, even more preferably 0.8 or less, and still more preferably 0.7 or less.

[0019] The polyol (b-1) is preferably a low molecular weight compound from the viewpoint of reducing skin irritation and suppressing rough hands, and from the viewpoint of suppressing volatilization of the antibacterial component polyol (b-2). The molecular weight of the polyol (b-1) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 200 or less, even more preferably 150 or less, and also preferably 50 or more, more preferably 60 or more, even more preferably 70 or more, even more preferably 80 or more.

[0020] The number of C atoms of polyol (b-1) is preferably 3 or more, more preferably 4 or more, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (b-2), which is an antibacterial component, and is preferably 24 or less, more preferably 18 or less, even more preferably 12 or less, still more preferably 8 or less, and even more preferably 6 or less. In addition, the number of OH groups in polyol (b-1) is preferably 2 or more and 6 or less, more preferably 2 or more and 5 or less, even more preferably 2 or more and 4 or less, and still more preferably 2, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (b-2), which is an antibacterial component.

[0021] The polyol (b-1) may be a chain polyol or a polyol having a cyclic structure, and any of these may be used, but from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing the volatilization of the polyol (b-2) which is an antibacterial component, the chain polyol is preferred, the chain diol or chain triol is more preferred, and the chain diol is even more preferred. In the chain polyol, the bonding position of the OH group is not particularly limited.

[0022] Examples of the linear polyol used as the polyol (b-1) include linear diols such as propylene glycol (1,2-propanediol) (0.67), 1,3-propanediol (0.67), 1,2-butylene glycol (0.5), 1,3-butylene glycol (0.5), 1,4-butylene glycol (0.5), and 2,3-butanediol (0.5); Linear triols such as 1,2,3-butanetriol (0.75), 1,2,4-butanetriol (0.75), 1,2,5-pentanetriol (0.6), 1,2,6-hexanetriol (0.5); Branched diols or triols such as 2-methyl-1,3-propanediol (0.5); Sugar alcohols with a ratio (number of OH groups / number of C atoms) of more than 0.45 and less than 1, such as maltitol (0.75), lactitol (0.75), and isomaltose (0.66); Polymers such as polyglycerin having a ratio (number of OH groups / number of C atoms) of more than 0.45 and less than 1; and the like, and one or more of these may be contained. The numbers in parentheses indicate the value of (number of OH groups / number of C atoms).

[0023] Among the above, from the viewpoints of reducing irritation to the skin and suppressing rough hands, and suppressing volatilization of the antibacterial component polyol (b-2), the polyol (b-1) is preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol), 1,3-butylene glycol, 1,2,6-hexanetriol, and 1,4-butylene glycol, more preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol) and 1,3-butylene glycol, and even more preferably 1,3-butylene glycol.

[0024] (Polyol (b-2)) From the viewpoint of improving antibacterial activity and its sustained effect, the (number of OH groups / number of C atoms) of the polyol (b-2) is 0.45 or less, preferably 0.40 or less, more preferably 0.35 or less, and also preferably 0.10 or more, more preferably 0.15 or more, and even more preferably 0.17 or more.

[0025] From the viewpoint of improving antibacterial activity and its sustained effect, the polyol (b-2) is preferably a low molecular weight compound. Specifically, the molecular weight of the polyol (b-2) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 200 or less, even more preferably 150 or less, and also preferably 70 or more, more preferably 80 or more, even more preferably 90 or more, even more preferably 100 or more.

[0026] The number of C atoms in the polyol (b-2) is preferably 5 or more, more preferably 6 or more, from the viewpoint that the hydrophobic portion containing a C atom distorts or destroys the three-dimensional hydrogen bond network of water, and is preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, still more preferably 12 or less, and even more preferably 11 or less. In addition, the number of OH groups in the polyol (b-2) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, even more preferably 2 or more and 3 or less, and still more preferably 2, from the viewpoint of improving antibacterial activity and its sustained effect.

[0027] The polyol (b-2) may be a chain polyol or a polyol having a cyclic structure, any of which may be used, but from the viewpoint that the hydrophobic part containing a C atom distorts or destroys the three-dimensional hydrogen bond network of water, the chain polyol is preferred, the chain diol or chain triol is more preferred, and the chain diol is even more preferred. In the chain polyol, the bonding position of the OH group is not particularly limited.

[0028] Examples of the chain polyol used as the polyol (b-2) include dipropylene glycol (0.33), tripropylene glycol (0.22), 1,2-pentanediol (0.44), 1,5-pentanediol (0.44), 1,2-hexanediol (0.33), 2,5-hexanediol (0.33), 1,6-hexanediol (0.33), 1,2-heptanediol (0.29), 1,7-heptanediol (0.29), 1,2-octanediol (0.29), and the like. linear diols such as diol (0.25), 1,8-octanediol (0.25), 1,2-nonanediol (0.22), 1,9-nonanediol (0.22), 1,2-decanediol (0.2), 1,10-decanediol (0.2), 1,2-dodecanediol (0.17), 1,12-dodecanediol (0.17), 1,2-tetradecanediol (0.14), 1,2-hexadecanediol (0.13), and 1,16-hexadecanediol (0.13); Linear triols such as 1,2,7-heptanetriol (0.43), 1,2,8-octanetriol (0.38), 1,2,9-nonanetriol (0.33), and 1,2,10-decanetriol (0.3); Branched diols or triols such as 2,2-dimethyl-1,3-propanediol (0.4), 3-methyl-1,3-butanediol (0.4), 2-methylpentane-2,4-diol (0.33), 2-ethyl-1,3-hexanediol (0.25), 2-butyl-2-ethyl-1,3-propanediol (0.22), 3-(2-ethylhexyloxy)-1,2-propanediol (0.18), (lauryl / myristyl) glycol hydroxypropyl ether (0.12-0.13), and 3,7,11,15-tetramethylhexadecane-1,2,3-triol (0.15); and and polymers such as polyethylene glycol having a ratio (number of OH groups / number of C atoms) of 0.45 or less. One or more of these may be contained. The numbers in parentheses indicate the value of (number of OH groups / number of C atoms).

[0029] Among the above, from the viewpoint of improving antibacterial activity and its sustained effect, the polyol (b-2) is preferably one or more selected from the group consisting of dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, and polyethylene glycol, and more preferably dipropylene glycol, 1, The alkyl group is at least one selected from the group consisting of 2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably at least one selected from the group consisting of dipropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, even more preferably at least one selected from the group consisting of dipropylene glycol and 3-(2-ethylhexyloxy)-1,2-propanediol, and even more preferably dipropylene glycol.

[0030] From the viewpoints of antibacterial durability and hand roughness inhibition effect, the content of the component (B) in the composition of the present invention is 2.5 mass% or more, preferably 2.7 mass% or more, more preferably 2.8 mass% or more, even more preferably 2.9 mass% or more, even more preferably 3.0 mass% or more, even more preferably 3.1 mass% or more, and is 10 mass% or less, preferably 9 mass% or less, more preferably 8 mass% or less, and even more preferably 7 mass% or less.

[0031] The composition of the present invention may contain a polyol other than the component (B), that is, a component (B') having a (number of OH groups / number of C atoms) of 1 or more (for example, glycerol). The content of component (B') having an (number of OH groups / number of C atoms) of 1 or more is, from the viewpoint of improving antibacterial activity and its sustained effect, preferably 30 parts by mass or less, more preferably 25 parts by mass or less, even more preferably 20 parts by mass or less, and even more preferably 16 parts by mass or less, per 100 parts by mass of component (B).

[0032] The mass ratio of polyol (b-1) to polyol (b-2) [(b-1) / (b-2)] is, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (b-2), which is an antibacterial component, preferably 0.01 or more, more preferably 0.03 or more, even more preferably 0.05 or more, still more preferably 0.08 or more, and is preferably 3.0 or less, more preferably 2.5 or less, even more preferably 2.0 or less, and still more preferably 1.5 or less.

[0033] <Ingredient (C)> The composition of the present invention contains, as component (C), one or more acids selected from the group consisting of lactic acid, pyruvic acid and urocanic acid or salts thereof.

[0034] Examples of salts of lactic acid, pyruvic acid, and urocanic acid include alkali metal salts such as potassium salts and sodium salts of lactic acid, pyruvic acid, and urocanic acid, alkaline earth metal salts such as calcium salts and magnesium salts, amine salts, ammonium salts, etc. Among these, from the viewpoint of improving antibacterial activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, one or more selected from the group consisting of alkali metal salts and alkaline earth metal salts of lactic acid, pyruvic acid, and urocanic acid are preferred, one or more selected from the group consisting of potassium salts, sodium salts, and calcium salts of lactic acid, pyruvic acid, and urocanic acid are more preferred, and one or more selected from the group consisting of potassium lactate, sodium lactate, and calcium lactate are even more preferred.

[0035] As component (C), from the viewpoint of improving antibacterial activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, one or more selected from the group consisting of lactic acid and its salts are preferred, one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate are more preferred, one or more selected from lactic acid and sodium lactate are even more preferred, and lactic acid and sodium lactate are even more preferred.

[0036] The content of the component (C) in the composition of the present invention is, from the viewpoints of antibacterial durability and hand roughness inhibition effect, 0.10 mass% or more, preferably 0.3 mass% or more, more preferably 0.5 mass% or more, even more preferably 0.7 mass% or more, still more preferably 0.9 mass% or more, and is 2.0 mass% or less, preferably 1.9 mass% or less, more preferably 1.8 mass% or less, even more preferably 1.7 mass% or less, still more preferably 1.6 mass% or less, and still more preferably 1.5 mass% or less.

[0037] When lactic acid and a salt thereof are used in combination, the lactic acid / salt thereof (mass ratio) is preferably 0.1 or more, more preferably 2.5 or more, even more preferably 0.4 or more, still more preferably 0.6 or more, still more preferably 0.8 or more, still more preferably 1.5 or more, and is preferably 20 or less, more preferably 15 or less, still more preferably 10 or less, still more preferably 8 or less, and still more preferably 6 or less, from the viewpoints of improving antibacterial activity and its sustained effect, and of reducing irritation to the skin and suppressing rough hands.

[0038] The total content of lactic acid and its salts in the total amount of component (C) is preferably 80% by mass or more, more preferably 90% by mass or more, even more preferably 95% by mass or more, and even more preferably 100% by mass, from the viewpoints of improving antibacterial activity and its sustained effect, and of reducing irritation to the skin and suppressing rough hands.

[0039] The mass ratio of component (B) to component (C) [component (B) / component (C)] is, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing evaporation of the antibacterial component polyol (b-2), preferably 1 or more, more preferably 1.5 or more, even more preferably 2.0 or more, still more preferably 2.5 or more, still more preferably 3.0 or more, and is preferably 7.5 or less, more preferably 7.0 or less, even more preferably 6.5 or less, and still more preferably 6.0 or less.

[0040] <Ingredient (D)> It is preferred that the composition of the present invention further contains, as component (D), a nonionic surfactant having a lipophilic group having 12 carbon atoms and an HLB (hydrophilic-lipophilic balance) of 8.9 or more and 17.0 or less.

[0041] In component (D), the lipophilic group having 12 carbon atoms can be a monohydric alcohol residue having 12 carbon atoms or a fatty acid residue having 12 carbon atoms. From the viewpoint of improving antibacterial activity and its sustained effect, the lipophilic group having 12 carbon atoms is preferably a group having a linear aliphatic group, and the linear aliphatic group is more preferably a linear saturated aliphatic group. More specifically, as the lipophilic group having 12 carbon atoms in component (D), from the viewpoint of improving antibacterial activity and its sustained effect, R 11 -O-, R 12 -COO- and R 12 Preferably, R is one or more selected from the group consisting of groups represented by -CONH-. 11 -O- and R 12 More preferably, R is one or more selected from the group consisting of groups represented by -COO-. 11 More preferably, R is a group represented by -O-. 11 is an aliphatic group having 12 carbon atoms, and R 12 is an aliphatic group having 11 carbon atoms. R 11 and R 12From the viewpoint of improving antibacterial activity and its sustained effect, the aliphatic group in is preferably a straight-chain aliphatic group, and more preferably a straight-chain saturated aliphatic group.

[0042] Component (D) may have only one lipophilic group having 12 carbon atoms, or may have two or more. From the viewpoint of improving antibacterial activity and its sustained effect, it is preferable that component (D) is mainly composed of a nonionic surfactant having only one lipophilic group having 12 carbon atoms. The term "main component" as used herein means that the main component occupies preferably 50% by mass or more, more preferably 70% by mass or more, and even more preferably 80% by mass or more of component (D), and may be 100% by mass.

[0043] Specific examples of component (D) include polyoxyethylene lauryl ether, sucrose laurate, polyoxyethylene laurate, polyglyceryl lauryl ether, polyglyceryl laurate, lauryl glucoside, polyoxyethylene laurylamine, polyoxyethylene sorbitan laurate, polyoxyethylene sorbit laurate, etc., and one or more of these can be used. Among these, from the viewpoint of improving antibacterial activity and its sustained effect, component (D) is preferably one or more selected from the group consisting of polyoxyethylene lauryl ether, sucrose laurate, polyoxyethylene laurate, polyglyceryl lauryl ether, polyglyceryl laurate, lauryl glucoside, and polyoxyethylene laurylamine.

[0044] Among the above, one or more selected from the group consisting of polyoxyethylene lauryl ether, polyoxyethylene laurate, polyoxyethylene laurylamine, polyoxyethylene sorbitan laurate, and polyoxyethylene sorbit laurate are preferred, and one or more selected from the group consisting of polyoxyethylene lauryl ether, polyoxyethylene laurate, and polyoxyethylene laurylamine are more preferred. The average number of moles of these oxyethylene groups added (hereinafter referred to as "average number of moles of EO added") is preferably 2 or more, more preferably 3 or more, even more preferably 5 or more, and even more preferably 7 or more from the viewpoint of improving the solubility and stability of the composition, and is preferably 25 or less, more preferably 24 or less, even more preferably 23 or less, and even more preferably 22 or less from the viewpoint of improving the antibacterial activity and its sustained effect, and obtaining a desired HLB value. The average number of moles of EO added is a number average value.

[0045] From the viewpoint of improving the solubility and stability of the composition, component (D) has an HLB of preferably 8.9 or more, more preferably 9.0 or more, more preferably 10.0 or more, even more preferably 11.0 or more, still more preferably 12.0 or more, and preferably 18.0 or less, more preferably 17.5 or less, even more preferably 17.0 or less, and still more preferably 16.8 or less. HLB (hydrophilic-lipophilic balance) indicates the ratio of the molecular weight of the hydrophilic group to the total molecular weight of a nonionic surfactant, and is calculated by the following Griffin formula. HLB = 20 x (molecular weight of hydrophilic group in nonionic surfactant molecular weight / molecular weight of nonionic surfactant)

[0046] From the viewpoints of antibacterial durability and hand roughness inhibitory effect, the content of the component (D) in the composition of the present invention is preferably 0.01 mass% or more, more preferably 0.03 mass% or more, even more preferably 0.05 mass% or more, even more preferably 0.08 mass% or more, even more preferably 0.15 mass% or more, and is preferably 2.0 mass% or less, more preferably 1.8 mass% or less, even more preferably 1.5 mass% or less, even more preferably 1.2 mass% or less, even more preferably 1.0 mass% or less, and even more preferably 0.8 mass% or less.

[0047] The mass ratio of component (B) to component (D) [component (B) / component (D)], from the viewpoint of improving antibacterial activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, is preferably 3.0 or more, more preferably 5.0 or more, even more preferably 8.5 or more, even more preferably 10.0 or more, even more preferably 15.0 or more, and is preferably 90 or less, more preferably 80 or less, even more preferably 70 or less, even more preferably 50 or less, even more preferably 40 or less, and even more preferably 35 or less.

[0048] <Ingredient (E)> The composition of the present invention preferably further contains a non-alcohol based disinfectant as component (E).

[0049] Examples of component (E) include one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, biguanide-based bactericides, terpenoid-based bactericides, chlorine-based bactericides, and amphoteric surfactant-based bactericides.

[0050] Examples of cationic disinfectants include quaternary ammonium salt compounds such as alkylpyridinium salts having an alkyl group with 8 to 18 carbon atoms, such as cetylpyridinium chloride, benzethonium salts such as benzethonium chloride, alkylbenzyldimethylammonium salts (benzalkonium chloride) having an alkyl group with 8 to 18 carbon atoms, and dialkyldimethylammonium salts having an alkyl group with 8 to 12 carbon atoms, such as didecyldimethylammonium chloride. Examples of the salts include chloride salts, methyl sulfates, and ethyl sulfates, with chloride salts being preferred. Examples of iodine-based disinfectants include povidone iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Phenol-based disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Biguanide disinfectants include chlorhexidine gluconate. Terpenoid fungicides include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based bactericides include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0051] The component (E) can be used alone or in combination of two or more. Among the above, from the viewpoint of improving antibacterial activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, component (E) is preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, and biguanide-based bactericides, and more preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, and biguanide-based bactericides. Among these, more preferred is one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone iodine, and chlorhexidine gluconate, and even more preferred is benzalkonium chloride having an alkyl group with 8 to 16 carbon atoms.

[0052] From the viewpoints of antibacterial durability and hand roughness inhibitory effect, the content of the component (E) in the composition of the present invention is preferably 0.01 mass% or more, more preferably 0.02 mass% or more, even more preferably 0.03 mass% or more, still more preferably 0.04 mass% or more, and is preferably 2.0 mass% or less, more preferably 1.5 mass% or less, even more preferably 1.0 mass% or less, still more preferably 0.5 mass% or less, still more preferably 0.3 mass% or less, and still more preferably 0.1 mass% or less.

[0053] <Other ingredients> The composition of the present invention may contain the following components (F), (G) and (H) in addition to the above components (A) to (E). Component (F) is a feel improver, and examples thereof include ester-based oils such as medium-chain fatty acid triglycerides and isopropyl myristate, hydrocarbon-based oils such as isododecane, hydrogenated polyisobutene, squalane, squalene, and liquid paraffin, and silicone-based oils such as cyclopentasiloxane, methylpolysiloxane, and dimethicone. Component (G) is a skin protective agent, and examples thereof include glycyrrhetinic acid, nicotinamide, ceramide, pseudoceramide, allantoin, hyaluronate, urea, tocopherol acetate, and dipotassium glycyrrhizinate. Component (H) is a thickener, examples of which include cellulose-based thickeners such as hydroxypropyl cellulose and hydroxyethyl cellulose, vinyl-based thickeners such as carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, polydiallyldimethylammonium chloride (polyquaternium), starch, agar, gelatin, guar gum, xanthan gum, carrageenan, etc.

[0054] The content of the component (F) in the composition of the present invention is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, even more preferably 1 mass% or less. The content of the component (G) in the composition of the present invention is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, even more preferably 1 mass% or less. The content of the component (H) in the composition of the present invention is preferably 0.01 mass% or more, more preferably 0.08 mass% or more, even more preferably 0.1 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, even more preferably 1 mass% or less.

[0055] The composition of the present invention may further contain other components, such as a pH adjuster (hydrochloric acid, sodium hydroxide, etc.), an ultraviolet absorber, an antioxidant, a preservative, an antiperspirant, a fragrance, a moisturizer (excluding components (B) and (G)), an anti-inflammatory agent, etc.

[0056] <Water> The composition of the present invention preferably further contains water from the viewpoint of dissolving or dispersing the components (A) to (C) and from the viewpoint of facilitating application to a target object such as the skin surface. When the composition of the present invention contains water, the content of water in the composition varies depending on the formulation, but from the viewpoint of dissolving or dispersing components (A) to (C) and facilitating application to the target object, it is preferably 10% by mass or more, more preferably 20% by mass or more, even more preferably 25% by mass or more, still more preferably 30% by mass or more, and is preferably 57% by mass or less, still more preferably 50% by mass or less, and still more preferably 45% by mass or less. The content of water in the composition of the present invention may be the balance of the components (A) to (C).

[0057] <ph> The pH of the composition of the present invention at 25°C is 4.0 or more, preferably 4.1 or more, and more preferably 4.2 or more, from the viewpoint of antibacterial durability, and is 6.5 or less, more preferably 6.0 or less, and even more preferably 5.5 or less, from the viewpoint of preventing rough hands. The pH of the composition of the present invention at 25° C. can be specifically measured by the method described in the Examples.

[0058] [How to disinfect the skin] The present invention can also provide a method for disinfecting skin, comprising the step of applying a composition of the present invention to the skin. The method for applying the composition of the present invention to the skin can be appropriately selected depending on the application site, etc. For example, the composition of the present invention can be applied by painting or spraying it onto the skin surface.

[0059] In the above-mentioned method, after applying the composition of the present invention to the skin, it is preferable to leave the composition on the skin surface without removing the composition by washing with water, etc. By using the composition as a leave-on disinfectant composition and leaving the components (A) to (C) on the skin surface, the composition exerts a sustained antibacterial effect and an inhibitory effect on rough hands.

[0060] In the step of applying the composition of the present invention to the skin, the amount of the composition to be applied is not particularly limited. From the viewpoint of exhibiting excellent antibacterial durability and hand roughness suppression effects, the composition is usually applied in an amount of preferably 0.1 mL to 5 mL per palm.

[0061] The composition of the present invention may be applied to the skin after washing in advance with water, soap, body soap, hand soap, etc., or may be applied to unwashed skin. Since the naturally occurring protective components of the skin are washed away after washing, and the defense power against bacteria and viruses present in the external environment is reduced after washing, it is more preferable to apply the composition to the skin after washing. EXAMPLES

[0062] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of the examples. In the examples, various measurements and evaluations were carried out by the following methods.

[0063] (pH) The pH of the composition was measured at 25° C. using an electrode 6367-10D (manufactured by Horiba, Ltd.). The calibration and measurement methods were as follows. A 100 ml beaker was filled with a pH 4.01 standard solution (phthalate standard solution), a pH 6.86 standard solution (neutral phosphate standard solution), and a pH 9.18 standard solution (borate standard solution), and the solution was left to stand in a thermostatic chamber at 25°C for 30 minutes. Of the standard solutions adjusted to a constant temperature of 25°C, a calibration operation was first performed by immersing a pH measurement electrode in the neutral phosphate standard solution for 3 minutes, and then a similar calibration operation was performed on the borate standard solution and then the phthalate standard solution. A 100 ml beaker was filled with the sample composition and left to stand in a thermostatic bath at 25° C. for 60 minutes or more. A pH measurement electrode was immersed in the sample adjusted to a constant temperature of 25° C. for 3 minutes to measure the pH.

[0064] [Evaluation of antibacterial durability] (Preparation of bacterial solution) To evaluate the antibacterial durability, a bacterial liquid of Serratia marcescens (NBRC12648 strain) prepared by the following method was used. Serratia marcescens (NBRC12648 strain) was inoculated into 4 mL of LB liquid medium (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., LB medium "Daigo") in a sterilized culture tube (Watson, 2332-012S), and cultured with shaking at 37 ° C. for 16 hours. After the culture was completed, the culture solution was dispensed into two sterilized microtubes (Watson, Hyper Microtube 132-620CS) at 1.6 mL each, and centrifuged at 8000 G for 3 minutes in a centrifuge (Tomy Seiko, MX-307). Next, after removing the LB liquid medium, 1.6 mL of pure water was added, mixed with a vortex mixer (Kenis, "Vortex-Genie2") for 30 seconds, centrifuged with a centrifuge at 8000 G for 3 minutes, and a washing operation to remove pure water was performed twice. Next, the Serratia bacteria were collected, and the solution in which the Serratia bacteria were suspended in pure water was measured for turbidity (OD) at a wavelength of 600 nm using a spectrophotometer (Eppendorf BioSpectrometer basic). 600 The concentration was adjusted to 10 to obtain a bacterial solution.

[0065] [a. Antibacterial activity (log reduction value) of alcohol-based disinfectant composition for skin] The subject's inner forearm was wetted with tap water at 20°C for 10 seconds, one push of "Biore u Rg" (Kao Corporation) was applied, the forearm was scrubbed for 30 seconds, and then rinsed with tap water at 20°C for 30 seconds. After waiting for 10 minutes in an environment of 25°C and 60% RH, an alcoholic disinfectant composition for skin described in Tables 1 and 2 was applied to the skin surface (2.0 cm) of the inner forearm. 2 range) to a certain amount (6.0 μL / cm 2 ) and applied evenly. After leaving it to stand for 2 hours and drying, a fixed amount (1.0 μL / cm ) of the bacterial liquid prepared by the above method was applied to the skin surface after applying an alcohol disinfectant for skin. 2 ), and evenly applied. After leaving it to stand for 10 minutes in this state, the applied bacterial liquid was collected using two culture swabs and 1.5 mL of neutralizing solution (3 g / L lecithin (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., lecithin, soybean-derived), 20 g / L Tween 80 (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., polyoxyethylene (20) sorbitan monooleate), 0.02 M disodium hydrogen phosphate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., disodium hydrogen phosphate dodecahydrate), 0.01 M sodium dihydrogen phosphate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., sodium dihydrogen phosphate dihydrate), 9 g / L sodium chloride (manufactured by Sigma-Aldrich, sodium chloride, biochemical grade) aqueous solution). Next, the number of viable bacteria was measured using an incubation reader "HiTS" (manufactured by Synix Corporation) by the method described below, and the reduction in the number of bacteria (number of viable bacteria / initial number of viable bacteria) was confirmed. The cells were cultured in a liquid culture reader "HiTS" at 37°C, and the absorbance (turbidity) OD at a wavelength of 600 nm was measured. 600 The number of viable bacteria in the bacterial solution was measured over time, and a growth curve of the number of viable bacteria in the bacterial solution was created. At the same time, a bacterial solution with a known number of viable bacteria was serially diluted, and similarly cultured and a growth curve was created, and a calibration curve of the time to reach a certain turbidity and the number of viable bacteria was created. From the relationship between the time to reach a certain turbidity for each sample and the calibration curve, the number of viable bacteria in the collected bacterial solution was estimated, and the reduction in the number of bacteria was confirmed. The degree of reduction in the number of bacteria (log reduction value) was calculated by taking the -log value of the reduction in the number of bacteria, and is shown as "Evaluation result a" in Tables 1 and 2. A larger value indicates a higher antibacterial activity.

[0066] [b. Antibacterial activity of pure water (log reduction value)] Pure water was used in place of the alcoholic disinfectant compositions for skin shown in Tables 1 and 2, and antibacterial activity was evaluated in the same manner as in a. above (evaluation result b).

[0067] Furthermore, the difference (ab) between the evaluation results a and b was calculated and is shown in Tables 1 and 2. The larger the value of this difference (ab), the higher the sustained antibacterial effect of the alcoholic disinfectant composition for skin.

[0068] Furthermore, the antibacterial properties were evaluated according to the following criteria. A: When the difference (ab) was 2.5 or more, it was evaluated as having excellent antibacterial durability. B: When the difference (ab) was 1.8 or more and less than 2.5, the antibacterial durability was evaluated as being at a level that poses no practical problem. C: When the difference (ab) was less than 1.8, the antibacterial durability was evaluated as low.

[0069] [Skin irritation evaluation] A three-dimensional skin model, which is known to be capable of predicting skin irritation in in vitro tests, was used to calculate the cell viability and evaluate skin irritation (Reference 1: Kato et al., 22nd Japanese Society for Alternatives to Animal Experiments (2009), Reference 2: LabCyte Epi-Model Instruction Manual). The three-dimensional skin model used was the LabCyte EPI-MODEL 24 (Labsite Epi-Model 24 Well) (hereafter referred to as Epi-Model) manufactured by Japan Tissue Engineering Co., Ltd. (abbreviated as J-TEC). This evaluation was performed under sterile conditions. The assay medium (hereafter referred to as assay medium) included with the Epimodel was preheated to 37°C and 0.5 mL was dispensed into each of the 24 wells. The Epimodel was transferred to the 24 wells into which the assay medium had been dispensed, and cultured under anaerobic conditions at 37°C and 5% CO2 for at least 1 hour. Then, 50 (μL) of each sample solution (undiluted solution of alcohol disinfectant composition for skin) was added to the surface of the epimodel and left for 7 minutes. At this time, the negative control was treated with saline. The solution was then discarded and washed 5 times with 0.5 (mL) of saline. The assay medium was replaced and cultured for 42 hours under anaerobic conditions at 37°C and 5% CO2. After discarding the assay medium, it was replaced with 0.5 (mg / mL) MTT (3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide, Kanto Chemical Co., Ltd.) / DMEM medium (Gibco BRL) pre-warmed to 37°C, and cultured for 3 hours under anaerobic conditions at 37°C and 5% CO2. After confirming that the negative control wells were stained blue-purple, human epidermal tissue was collected. The epidermal tissue was added to a microtube, 0.5 (mL) of isopropyl alcohol (hereinafter abbreviated as IPA) (manufactured by Wako Pure Chemical Industries, Ltd.) was added, and the mixture was left to stand at 4 ° C. in a dark place for more than one night. 0.2 (mL) of the extraction solution was taken and added to 96 wells (the same amount of IPA was added to the blank). The absorbance at 570 (nm) and 650 (nm) was measured for each of the sample, negative control (saline), and blank, and the absorbance value at 650 (nm) was subtracted from the absorbance value at 570 (nm) and used as the absorbance value (Bs, Bn, Bb) used in the following calculation formula. The viability was calculated using the following formula. The higher this value, the higher the effect of the alcohol disinfectant composition for skin in inhibiting rough hands. Viable cell rate (%)=100×(Bs-Bb) / (Bn-Bb)

[0070] During the ceremony, Bs: Sample absorbance Bn: negative control (saline) absorbance Bb: Blank (IPA only) absorbance

[0071] Furthermore, skin irritation was evaluated according to the following criteria. A: When the viable cell rate is 75% or higher, it is evaluated as having less irritation to the skin and being particularly effective in preventing rough hands. B: When the viable cell rate is 55% or more and less than 75%, it is evaluated that the skin irritation is minimal and the effect of inhibiting rough hands is at a level that does not pose a problem in practical use. C: When the viable cell rate was less than 55%, it was evaluated as causing a lot of skin irritation and having a low effect in inhibiting rough hands.

[0072] Examples 1 to 13, Comparative Examples 1 to 6 The components shown in Tables 1 and 2 were mixed in the amounts shown in Tables 1 and 2 at room temperature, and then the pH was adjusted to the values ​​shown in the tables using a 1 mol / L aqueous hydrochloric acid solution and / or a 1 mol / L aqueous sodium hydroxide solution as a pH adjuster to prepare alcoholic skin disinfectant compositions. The amounts shown in Tables 1 and 2 are the amounts of active ingredients (% by mass) of each component. The obtained alcohol-based disinfectant composition for skin was evaluated by the above-mentioned method, and the results are shown in Tables 1 and 2.

[0073] [Table 1]

[0074] [Table 2]

[0075] The ingredients listed in Tables 1 and 2 are as follows. The amounts listed in the tables are the active ingredients. <Component (A)> a-1 Ethanol: "Fermented alcohol 95% Grade 1" manufactured by Godo Shusei Co., Ltd. <Ingredient (B)> b-1 1,3-Butylene glycol: "1,3-Butylene glycol-P" manufactured by KH Neochem Co., Ltd. b-2 Dipropylene glycol: ADEKA Corporation "DPG-RF" <Component (B')> b'-1 Glycerol: "Japanese Pharmacopoeia Glycerin" manufactured by Kao Corporation <Ingredient (C)> c-1 Lactic acid: Musashino Chemical Laboratory Co., Ltd. "Musashino Lactic Acid 90" c-2 Sodium lactate: Musashino Chemical Laboratory Co., Ltd. "Sodium lactate solution 50%" <Ingredient (D)> d-1 Polyoxyethylene (9) lauryl ether: Kao Corporation's "Emulgen 109P", HLB 13.6, average EO molar addition number 9 d-2 Polyoxyethylene (21) lauryl ether: Kao Corporation's "Emulgen 121-G", HLB 16.6, average EO molar addition number 21 <Ingredient (E)> e-1 Benzalkonium chloride: "Sanisol C" manufactured by Kao Corporation, linear alkylbenzyldimethylammonium chloride with an alkyl group having 8 to 16 carbon atoms <Component (F)> f-1 Medium-chain fatty acid triglyceride: Kao Corporation's "Coconard MT", a triester of fatty acids with 8 to 10 carbon atoms and glycerin <Ingredients (G)> g-1 Glycyrrhetinic acid: "Glycyrrhetinic acid" manufactured by Alps Pharmaceutical Co., Ltd. <Ingredients (H)> h-1 Hydroxypropyl cellulose: "HPC-H" manufactured by Nippon Soda Co., Ltd., weight average molecular weight 1 million, viscosity 1000-4000 mPa·s [20℃ / 2% aqueous solution] <Other ingredients> Nicotinamide: "Nicotinamide" manufactured by Yuki Gosei Yakuhin Kogyo Co., Ltd.

[0076] From the results shown in Tables 1 and 2, the following was confirmed. In Examples 1 to 13, both the antibacterial durability and the effect of inhibiting rough hands were rated as "B" or higher, confirming that an alcohol-based disinfectant composition for skin was obtained that had excellent antibacterial durability, was less irritating to the skin, and was also effective in inhibiting rough hands. On the other hand, in Comparative Examples 1 to 6, either the antibacterial durability or the effect of inhibiting rough hands was rated as "C," confirming that the antibacterial durability or effect of inhibiting rough hands was inferior to that of Examples 1 to 13. [Industrial Applicability]

[0077] According to the present invention, it is possible to provide an alcohol disinfectant composition for skin which has excellent antibacterial durability, is less irritating to the skin, and has an excellent effect of inhibiting rough hands.< / ph>

Claims

1. Component (A): ethanol and / or isopropanol, Component (B): a polyol satisfying the formula (number of OH groups / number of carbon atoms) < 1, and Component (C): One or more acids or salts thereof selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid An alcohol-based disinfectant composition for skin comprising: The content of the component (A) is 40% by mass or more and 95% by mass or less, The content of the component (B) is 2.5% by mass or more and 10% by mass or less, The content of the component (C) is 0.10% by mass or more and 2.0% by mass or less, An alcohol-based disinfectant composition for skin, having a pH of 4.0 or more and 6.5 or less at 25°C.

2. The component (B) contains a polyol (b-1) having a (number of OH groups / number of C atoms) of more than 0.45 and a polyol (b-2) having a (number of OH groups / number of C atoms) of 0.45 or less. The alcoholic disinfectant composition for skin according to claim 1.

3. The mass ratio of the polyol (b-1) to the polyol (b-2) [(b-1) / (b-2)] is 0.05 or more and 3.0 or less. The alcohol disinfectant composition for skin according to claim 2.

4. The alcohol disinfectant composition for skin according to any one of claims 1 to 3, wherein the mass ratio [(B) / (C)] of the component (B) to the component (C) is 1.5 or more and 7.5 or less.

5. Furthermore, component (D): a nonionic surfactant having a lipophilic group having 12 carbon atoms and an HLB of 8.9 or more and 17.0 or less. Contains The alcoholic disinfectant composition for skin according to any one of claims 1 to 4, wherein the content of component (D) is 0.03% by mass or more and 2.0% by mass or less.

6. The alcohol disinfectant composition for skin according to claim 5, wherein the mass ratio [(B) / (D)] of the component (B) to the component (D) is 3.0 or more and 90 or less.

7. Further, component (E): one or more selected from the group consisting of cationic bactericides, iodine bactericides, phenol bactericides, biguanide bactericides, terpenoid bactericides, chlorine bactericides, and amphoteric surfactant bactericides. Contains The alcohol disinfectant composition for skin according to any one of claims 1 to 6, wherein the content of component (E) is 0.01% by mass or more and 0.5% by mass or less.

8. A method for disinfecting skin, comprising a step of applying an alcohol-based disinfectant composition for skin according to any one of claims 1 to 7 to the skin.

Images