Cleaning system for diaphragm pump

Abstract

To provide a system for cleaning a single-port diaphragm pump.SOLUTION: The system cleans a single-port fluidic device (100), such as a cardiac pump, with a continuous stream of fresh cleaning fluid (700) while simultaneously draining soiled fluid (702) via a single input-output port (108). A coupler (304) releasably mates with the input-output port and includes an injector nozzle (610) and a return port (612). The injector nozzle is oriented to direct a stream of cleaning fluid toward an interior chamber (110) of the single-port fluidic device. The return port simultaneously removes soiled cleaning fluid from the interior chamber. A circulation pump delivers the pressurized cleaning fluid from a tank to the injector nozzle and returns soiled cleaning fluid from the return port to the tank, via a cleaning fluid circulation circuit.SELECTED DRAWING: Figure 7

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application No. 62 / 910,078, "Cleaning System for Diaphragm Pump," filed October 3, 2019, the entire contents of which are incorporated herein by reference for all purposes.

[0002] Technical Field The present invention relates to a cleaning system for a pump, and more particularly to a cleaning system for a single port diaphragm pump. [Background technology]

[0003] Related Technology Heart pumps and other medical devices implanted in or otherwise connected to a patient must be clean and sometimes sterile before use. Pumps and other "plumbing" equipment used to process food, drugs, and other products have similar requirements. Multi-ported fluidic devices are relatively easy to clean, for example by flushing. A continuous stream of fresh cleaning fluid may be introduced through one port while dirty fluid is drained through another port.

[0004] However, single-port fluidic devices, such as the Symphony cardiac assist device introduced by Abiomed, Inc., Danvers, MA, are known to be difficult to clean. Each such device has only one port therein. As a result, the pump interior cannot be simply flushed by continuously introducing cleaning fluid into a first port and simultaneously withdrawing dirty cleaning fluid through a second port. Conventional cleaning devices and protocols do not allow for the continuous and simultaneous replacement of dirty cleaning fluid with fresh cleaning fluid.

[0005] Instead, single-port fluidic devices must either be disassembled for cleaning or alternate between filling and emptying steps through the single port. For example, single-port fluidic devices may be cleaned by introducing cleaning fluid through the single port, shaking the device, draining the used cleaning fluid, and then repeating these steps. However, testing has shown that this method does not adequately clean devices intended for critical use, such as pumping human blood. For example, alternating between filling and emptying a single-port fluidic device inevitably contaminates the device with dirty fluids that were recently in the device. Either method is time consuming and often produces unsatisfactory results. Summary of the Invention

[0006] Overview of Aspects One aspect of the invention provides a cleaning system for a diaphragm pump. The diaphragm pump includes a housing, a diaphragm disposed within the housing, and an input / output port. The diaphragm and at least a portion of the housing collectively define a pump chamber interior. The input / output port is in fluid communication with the pump chamber interior.

[0007] The cleaning system includes a tank configured to store a cleaning fluid.

[0008] A first coupler is configured to releasably mate with the input / output port, thereby creating a fluid-tight connection with the input / output port. The first coupler includes an injector nozzle. The injector nozzle has an input end and an output end. The injector nozzle is configured to be in fluid communication with and oriented to direct a fluid stream toward the interior of the pump chamber while the first coupler is mated with the input / output port.

[0009] The first coupler also includes a return port adjacent to and separate from the output end of the injector nozzle such that the return port is in fluid communication with the interior of the pump chamber while the first coupler is mated with the input / output port.

[0010] The injector nozzle is configured to direct a stream into the interior of the pump chamber while the return port drains the interior of the pump chamber.

[0011] The cleaning system of the present invention also includes a circulation pump. The circulation pump has an input and an output. A cleaning fluid circulation circuit is in fluid communication with the tank, the input and output of the circulation pump, the input end of the injector nozzle, and the output port. The cleaning fluid circulation circuit is configured to deliver pressurized cleaning fluid from the tank to the injector nozzle and to return used cleaning fluid from the output port to the tank.

[0012] In any embodiment, the cleaning system may further include a first two-way valve in the circulation circuit of the cleaning fluid. The first two-way valve has an input, a first output, and a second output. The first two-way valve is user-configurable to one of two states. The first two-way valve is configured to fluidly communicate the input with either the first output or the second output depending on the state of the first two-way valve. The input is coupled to an output of the circulation pump. The first output is coupled to an input end of the injector nozzle and the second output is coupled to a tank, thereby bypassing the first coupler.

[0013] In any embodiment including a first two-way valve, the cleaning system may further include a purge port and a second two-way valve in the cleaning fluid circulation circuit. The second two-way valve has an input, a first output, and a second output. The second two-way valve is user-configurable to one of two states. The second two-way valve is configured to fluidly communicate the input of the second two-way valve with either the first output of the second two-way valve or the second output of the second two-way valve depending on the state of the second two-way valve. The input of the second two-way valve is coupled to the output of the circulation pump. The first output of the second two-way valve is coupled to the input of the first two-way valve, and the second output of the second two-way valve is coupled to the purge port.

[0014] In any embodiment, the circulation pump may be pneumatically driven. In any embodiment, the circulation pump may be electrically driven.

[0015] In any embodiment usable with a diaphragm pump including a pneumatic diaphragm actuation port, the cleaning system may further include a second coupler. The second coupler may be configured to releasably mate with the pneumatic diaphragm actuation port, thereby creating a gas-tight connection with the pneumatic diaphragm actuation port. The cleaning system may also include a gas source. The gas source may be configured to supply gas to the second coupler at a pressure that alternates at a frequency of about 0.1 Hz to about 10 Hz. The gas source may be configured to supply gas to the second coupler between a first pressure and a second pressure. The second pressure may be at least about 1.45 PSI (9,997 Pa) greater than the first pressure.

[0016] Optionally, in embodiments that are usable with a diaphragm pump that includes a pneumatic diaphragm actuation port, the gas source may include a pneumatically actuated venturi configured to provide gas at approximately 2-3 inHg (6,772.78-10,159.2 Pa).

[0017] Optionally, in embodiments usable with a diaphragm pump that includes a pneumatic diaphragm actuation port, the first pressure may be less than ambient atmospheric pressure and the second pressure may be greater than ambient atmospheric pressure. [Brief description of the drawings]

[0018] The present invention will be more fully understood from the following detailed description of illustrative embodiments taken in conjunction with the drawings, in which:

[0019] [Figure 1] 1A and 1B are perspective and side views, respectively, of an exemplary prior art single port diaphragm pump that may be cleaned using aspects of the present invention; [Diagram 2] 1A and 1B are perspective and side views, respectively, of an exemplary prior art single port diaphragm pump that may be cleaned using aspects of the present invention; [Diagram 3] FIG. 3 is a perspective view of a cleaning system for a diaphragm pump, such as the exemplary single port diaphragm pump of FIGS. 1 and 2, according to one embodiment of the present invention. [Figure 4] FIG. 4 is a perspective view of the inside of the control box / console of the cleaning system of FIG. 3. [Diagram 5] FIG. 4 is a schematic piping diagram of the cleaning system of FIG. 3. [Figure 6] FIG. 4 is a front perspective view of a business end of a first coupler of the cleaning system of FIG. 3 according to one embodiment of the present invention, configured to releasably mate with, and thereby create a fluid-tight connection with, an input / output port of a diaphragm pump, such as the exemplary single-port diaphragm pump of FIGS. 1 and 2. [Figure 7] FIG. 7 is a cross-sectional view of a portion of the first coupler of FIG. 6 with the exemplary single-port diaphragm pump of FIGS. 1 and 2 attached thereto according to one embodiment of the present invention, illustrating an exemplary flow pattern of cleaning fluid being injected into and simultaneously removed from the single-port diaphragm pump by the first coupler. [Figure 8]FIG. 7 is a front view of the functional end of the first coupler of FIG. 6 with a protective plug installed to prevent contamination of the first coupler when not in use, according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0020] DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS Aspects of the present invention provide an apparatus and method for cleaning a single port fluidic device, such as the previously described Symphony cardiac assist device, with a continuous stream of fresh cleaning fluid through a single port while simultaneously draining dirty fluid. Although aspects of the present invention can be used with other single port fluidic devices, and even multi-port fluidic devices, they are described herein in the context of cleaning the Symphony single port cardiac assist device.

[0021] 1 and 2 are perspective and side views, respectively, of a Symphony cardiac assist device 100. The Symphony device 100 serves as an exemplary single-port diaphragm pump 100 that may be cleaned using embodiments of the present invention. The Symphony cardiac assist device 100 is also referred to herein as a single-port diaphragm pump 100.

[0022] The Symphony device 100 is a valveless counterpulsation cardiac assist device designed for superficial implantation within a patient's "pacemaker pocket." The Symphony device 100 includes a housing 102 and a pneumatically actuated sac that includes a flexible diaphragm 104 (not visible but shown in phantom). The diaphragm 104 is actuated by a small, wearable pneumatic driver (not shown) that is connected to the sac by a percutaneous airline 106. The Symphony device 100 has a single input / output port 108 that is connected to the patient's subclavian artery via a conduit. The inset of FIG. 1 shows a portion of the Symphony device 100 with a conduit 109 coupled to the single input / output port 108.

[0023] The pneumatic driver is synchronized to the patient's heartbeat based on an electrocardiogram (ECG) signal from the patient's heart. The Symphony device 100 fills with blood from the arteries during the heart's natural expansion, reducing the workload of the heart muscle. The Symphony device 100 ejects blood back into the arteries during the heart's natural contractions, increasing systemic blood flow, thereby improving the patient's overall health.

[0024] The diaphragm 104 is disposed within the housing 102. The diaphragm 104 and at least a portion of the housing 102 collectively define a fluid-tight interior volume (pump chamber interior) 110 in fluid communication with a single input / output port 108. One side of the diaphragm 104 faces the interior volume 110. The single input / output port 108 is mechanically attached to the housing 102 and may include a threaded or other type of releasable mating feature 111 configured to releasably mate with a conduit 109.

[0025] In use, the input / output port 108 is coupled in fluid communication with the patient's cardiovascular (blood circulatory) system via conduit 109. No other ports are in fluid communication with the interior volume 110, and therefore the device of the present invention is referred to as a "single-port" fluidic device.

[0026] The other side of the diaphragm 104 and at least a portion of the housing 102 define a second interior volume 112. A pneumatic activation port 114 is in fluid communication with the second interior volume 112. In use, the pneumatic activation port 114 is connected in fluid communication by an airline 106 to a small, wearable pneumatic driver (not shown) or another suitable source of alternating pressure and suction, which causes the diaphragm 104 to reciprocate. The reciprocating diaphragm 104 pumps a fluid, such as blood, alternately into and out of the first interior chamber 110 via the input / output port 108.

[0027] 3 is a perspective view of a cleaning system 300 for a diaphragm pump, such as the exemplary Symphony device 100. The exemplary single port diaphragm pump 100 is shown attached to the cleaning system 300 for cleaning by the system 300. The system 300 may be mounted on a mobile cart 302. However, in other embodiments, the system 300 may be bench mounted, cabinet mounted, etc. The system 300 may be mobile, portable, stationary, or fixed in place.

[0028] The system 300 includes a first coupler 304 configured to releasably mate with the input / output port 108 of the single port diaphragm pump 100. The system 300 also includes a tank 306 configured to store a suitable cleaning fluid, a circulation pump 308, and a cleaning fluid circulation circuit (shown generally at 310).

[0029] The cleaning fluid circuit 310 may include various valves, pressure / vacuum gauges, etc., some or all of which may be located in or on a control box / console 312 that provides a user interface to the system 300. Figure 4 is a perspective view of the inside of the control box / console 312.

[0030] The control box / console 312 may also house a controller 400 that automatically measures pressure, vacuum, flow rate, user input via switches or dials, etc. The controller 400 may also monitor other parameters of the cleaning fluid circuit 310, control the operation of some or all of the valves, etc., and / or display information via a suitable display screen, panel lights, annunciators, etc. The controller 400 may include a processor that executes instructions stored in memory to perform these and other operations described herein.

[0031] Figure 5 is a schematic plumbing diagram 500 of cleaning system 300. As previously described, cleaning system 300 includes a first coupler 304 configured to releasably mate with input / output port 108 of diaphragm pump 100. When mated with input / output port 108, first coupler 304 forms a fluid-tight connection with input / output port 108. Figure 6 is a front perspective view of a functional end of first coupler 304.

[0032] The first coupler 304 may include a latch 600 configured to releasably lock the input / output port 108 to the first coupler 304. As previously mentioned, the input / output port 108 may include flanges, threads, or other connecting features 111 for firmly or rigidly connecting the conduit 109 to the input / output port 108.

[0033] In the embodiment shown in Figure 6, the latch 600 is in the form of a yoke 602 slidably attached to the first coupler 304 by two screws 604. A slot 606 in the latch 600 allows the yoke 602 to translate vertically between two positions defined by the vertically separated ends of the slot 606. In one position, shown in solid lines in Figure 6, the yoke 602 allows the input / output port 108 to enter the latch 600 and mate with the first coupler 304.

[0034] A portion 607 of the opening defined by the yoke 602 is narrower than the remainder of the opening defined by the yoke 602. In a second position 608, as shown in Figure 3 and shown in dashed lines in Figure 6, the portion 607 of the yoke 602 mechanically captures the feature 111 of the input / output port 108 and presses it against the first coupler 304 to form a fluid-tight connection between the input / output port 108 and the first coupler 304. After the diaphragm pump 100 has been cleaned, the yoke 602 may be returned to the first position, thereby freeing the feature 111 and allowing the input / output port 108 to be pulled out of the latch 600, thereby disengaging from the first coupler 304.

[0035] 6 and 7, the first coupler 304 includes an injector nozzle 610 that is configured to inject and target the cleaning fluid 700 into the interior 110 of the diaphragm pump 100. The first coupler 304 also includes a return port 612 that is also in fluid communication with the interior 110 of the diaphragm pump 100 when the first connector 304 is mated with the input / output port 108. In the embodiment shown in FIG. 6, the return port 612 includes a plurality of apertures arranged in a circular configuration.

[0036] 6 and 7, two such apertures 612 are numbered. However, any number of apertures 612 may be used, and when multiple apertures 612 are used, the apertures 612 may be arranged in any arrangement. The arrangement may, but need not, surround the injector nozzle 610. The injector nozzle 610 may, but need not, be coaxial with the arrangement of return ports 612. The collective cross-sectional area of ​​the apertures 612 (measured perpendicular to the longitudinal axis 312 of the first coupler 304) may, but need not, be equal to or exceed the cross-sectional area of ​​the injector nozzle 610.

[0037] As shown in FIG. 7, fresh cleaning fluid 700 may be injected into the interior 108 of the diaphragm pump 100 by the injector nozzle 610, and contaminated fluid may be simultaneously removed from the interior 108 by the return port 612.

[0038] FIG. 8 is a front view of the functional end of the first coupler 304 fitted with a protective plug 800 to prevent contamination of the first coupler 304 when not in use.

[0039] Returning to the plumbing schematic 500 (FIG. 5) of the cleaning system 300, a tank 306 stores cleaning fluid. A circulation pump 308 draws cleaning fluid from the tank 306 and delivers the cleaning fluid under pressure to an injector nozzle 610, which directs a high-pressure stream of cleaning fluid 700 (FIG. 7) into the interior 110 of the diaphragm pump 100. Spent cleaning fluid 702 exits the diaphragm pump 100 via an outlet port 612 and returns to the tank 306; this completes the cleaning fluid circuit as generally indicated by the series of solid arrows 502 (FIG. 5). Suitable filters, valves, pressure regulators, and access ports / vents are located along the cleaning fluid circuit 502.

[0040] During cleaning, the diaphragm 104 (FIG. 1) may be alternately actuated between two positions in the same manner that the diaphragm 104 is actuated during normal operation of the diaphragm pump 100. This action by the diaphragm 104 agitates the cleaning fluid 700 to increase cleaning efficiency. As previously mentioned, the diaphragm pump 100 includes a pneumatic actuation port 114. During cleaning, the pneumatic diaphragm actuation port 114 may be coupled to an alternating gas pressure source 505 via a second releasable coupler 504 (FIG. 5).

[0041] Alternating gas pressure source 505 may include a venturi vacuum generator 506 (referred to herein as a "venturi" for simplicity) configured to generate a relative partial vacuum (referred to herein as a "relative vacuum"), and a compressed gas source 508. A toggle valve 510 couples the relative vacuum and compressed gas to pneumatic diaphragm actuation port 114 of diaphragm pump 100. Toggle valve 510 alternately supplies the relative vacuum and compressed gas to pneumatic diaphragm actuation port 114 at a frequency between about 0.1 Hz and about 10 Hz.

[0042] Toggle valve 510 may be controlled by controller 400 (FIG. 4), for example, in coordination with the supply of cleaning fluid. The relative vacuum and compressed gas should be sufficiently different in pressure to drive diaphragm 104 over most or all of the design course. In some embodiments, the relative vacuum has a pressure less than ambient atmospheric pressure, and the compressed gas has a pressure greater than ambient atmospheric pressure.

[0043] Depending on the type of circulation pump 308 used, the cleaning fluid circuit 502 may include a two-way valve 511 and a purge port 512 downstream of the circulation pump 308. A syringe (not shown) may be inserted into the purge port 512 to purge air from the circulation pump 308 and may be used to create a partial vacuum to draw cleaning fluid from the tank 306 into the circulation pump 308.

[0044] The cleaning fluid circuit 502 may include a two-way valve 514. As described above, in one position, the two-way valve 514 directs the cleaning fluid from the circulation pump 308 to the injector nozzle 610. In the other position, the two-way valve 514 directs the cleaning solution back to the tank 306, bypassing the first coupler 304, as indicated by dashed arrow 516, to flush air and contaminants from at least a portion of the cleaning fluid circuit 502.

[0045] An external source 518 of compressed gas, such as air, may be used to drive the circulation pump 308 and venturi 506 and to feed the compressed gas source 508. However, to prevent compressor or motor oil fumes from contaminating the diaphragm 104, the gas source 518 should be isolated, such as by an isolation pressure regulator 520 and 522. Alternatively, the circulation pump 308 may be electrically operated.

[0046] The air pressure in the compressed gas source 508 should be within the range of approximately 6-8 PSI (41,368.5-55,158.1 Pa) to adequately reciprocate the diaphragm 104 in the Symphony device 100. For other single-port fluidic devices 100, the appropriate air pressure range for the compressed gas source 508 may be determined empirically or theoretically, such as based on the mechanical properties of the single-port fluidic device 100.

[0047] To adequately reciprocate the diaphragm 104 in the Symphony device 100, the relative partial vacuum created by the venturi 506 should be set within the range of about 2-3 inHg (6,772.78-10,159.2 Pa). For other single-port fluidic devices 100, the appropriate partial vacuum may be determined empirically or theoretically, such as based on the mechanical properties of the single-port fluidic device 100.

[0048] The cleaning system 300 is suitable for any single port pump 100. Whereas the manual method for cleaning the single port pump 100 does not drive the diaphragm 104, the cleaning system 300 can automatically drive the diaphragm 104, thereby agitating the cleaning fluid 700. The cleaning system 300 simultaneously (a) injects the cleaning fluid 700 under pressure into the interior 110 of the diaphragm pump 100, and (b) withdraws the used cleaning fluid 702 from the interior 110. Thus, the cleaning fluid 702 inside the diaphragm pump 100 is continuously replaced with the clean fluid 7-2. Because the used cleaning fluid 702 is almost immediately drained from the interior 110 of the diaphragm pump 100, it cannot redeposit contaminants on the interior of the diaphragm pump. Any contaminants left behind by the used cleaning fluid 702 are washed out by the fresh cleaning fluid 700 .

[0049] Although the present invention has been described through the above exemplary embodiments, modifications and variations to the illustrated embodiments are possible without departing from the inventive concept disclosed herein. For example, specific parameter values ​​such as dimensions and materials may be stated in the context of the disclosed embodiments, but within the scope of the present invention, the values ​​of all parameters may vary over a wide range to suit different applications. Unless otherwise indicated in the context or understood by those skilled in the art, terms such as "about" mean within ±20%.

[0050] In this specification and in the claims, the term "and / or" when used in connection with a list of items means one or more of the items in the list, i.e., at least one of the items in the list, but not necessarily every item in the list. In this specification and in the claims, the term "or" when used in connection with a list of items means one or more of the items in the list, i.e., at least one of the items in the list, but not necessarily every item in the list. "Or" does not mean "exclusive or."

[0051] Aspects of the embodiments may be described with reference to flowcharts and / or block diagrams, although the functions, operations, decisions, etc. of all or a portion of each block or combination of blocks may be combined, separated into separate operations, or performed in other orders. References to "modules" are for convenience and are not intended to limit the embodiment. All or a portion of each block, module, or combination thereof may be implemented as computer program instructions (e.g., software), hardware (e.g., combinatorial logic, application specific integrated circuit (ASIC), field programmable gate array (FPGA), processor, or other hardware), firmware, or a combination thereof.

[0052] The controller 400, or portions thereof, may be implemented by one or more processors that execute or are controlled by instructions stored in a memory. Each processor may be a general-purpose processor such as a central processing unit (CPU), a graphics processing unit (GPU), a digital signal processor (DSP), a special-purpose processor, or the like, or a combination thereof, as appropriate.

[0053] The memory may be a random access memory (RAM), a read only memory (ROM), a flash memory, or any other memory, or combination thereof, suitable for storing control software or other instructions and data. The instructions that define the functionality of the present invention may be delivered to the processor in many forms, including, but not limited to, information permanently stored on a non-transitory, non-writable tangible storage medium (e.g., a read only memory device within the computer, such as a ROM, or a device readable by the I / O accessories of the computer, such as a CD-ROM or DVD disk), information alterably stored on a non-transitory, writable tangible storage medium (e.g., a floppy disk, a removable flash memory, and a hard drive), or information communicated to the computer over a communication medium, including a wired or wireless computer network. Additionally, although aspects may be described in conjunction with various exemplary data structures, the system may be embodied using a variety of data structures.

[0054] The aspects of the present disclosure, or portions thereof, may be combined in ways not recited above and / or not expressly claimed.In addition, the embodiments disclosed herein may be suitably implemented in the absence of any element not specifically disclosed herein.Therefore, the present invention should not be viewed as being limited to the disclosed embodiments.

[0055] As used herein, numerical terms such as "first," "second," and "third" are used, etc., to distinguish respective couplers, switch positions, internal volumes, valves, outputs, etc. from one another, and are not intended to indicate a particular order or total number of couplers, switch positions, internal volumes, valves, outputs, etc. in any particular embodiment. Thus, for example, a given embodiment may include only a second valve and a third valve.

Claims

1. A cleaning system (300) for a diaphragm pump (100), the diaphragm pump comprising a housing (102), a diaphragm (104) disposed within the housing, and an input / output port (108), the diaphragm and at least a portion of the housing collectively defining a pump chamber interior (110), the input / output port being in fluid communication with the pump chamber interior; The cleaning system comprises: A tank (306) configured to store a cleaning fluid; a first coupler (304) configured to releasably mate with the input / output port, thereby creating a fluid-tight connection with the input / output port; an injector nozzle (610) having an input end and an output end, the injector nozzle (610) being configured to be in fluid communication with and oriented to direct a fluid stream (700) toward an interior of the pump chamber while the first coupler is mated with the input / output port; and a return port (612) adjacent to and separate from the output end of the injector nozzle, the return port (612) configured to be in fluid communication with the interior of the pump chamber while the first coupler is mated with the input / output port; Equipped with a first coupler (304), the injector nozzle configured to direct the stream into the interior of the pump chamber at the same time that the return port drains the interior of the pump chamber (702); a circulation pump (308) having an input and an output; a cleaning fluid circulation circuit (310) in fluid communication with the tank, the input and the output of the circulation pump, the input end of the injector nozzle, and the output port, and configured to deliver pressurized cleaning fluid from the tank to the injector nozzle and return used cleaning fluid from the output port to the tank; A cleaning system (300).

2. The cleaning system further comprises a first two-way valve (514) in the cleaning fluid circulation circuit, the first two-way valve having an input, a first output, and a second output; the first two-way valve is user-settable to one of two states and configured to fluidly connect the input to either the first output or the second output depending on the state of the first two-way valve, where the input is coupled to an output of a circulation pump, the first output is coupled to an input end of an injector nozzle, and the second output is coupled to a tank, thereby bypassing a first coupler; 2. The cleaning system of claim 1.

3. The cleaning system further comprises a purge port (512) and a second two-way valve (511) in the cleaning fluid circulation circuit, the second two-way valve having an input, a first output, and a second output; the second two-way valve is user-settable to one of two states and configured to place the input of the second two-way valve in fluid communication with either the first output of the second two-way valve or the second output of the second two-way valve depending on the state of the second two-way valve, where the input of the second two-way valve is coupled to an output of a circulation pump, the first output of the second two-way valve is coupled to an input of the first two-way valve, and the second output of the second two-way valve is coupled to the purge port; 3. The cleaning system of claim 2.

4. 10. The cleaning system of claim 1, wherein the circulation pump is pneumatically driven.

5. 10. The cleaning system of claim 1, wherein the circulation pump is electrically driven.

6. the diaphragm pump further comprising a pneumatic diaphragm actuation port (114); The cleaning system comprises: a second coupler (504) configured to releasably mate with the pneumatic diaphragm actuation port, thereby creating a gas-tight connection with the pneumatic diaphragm actuation port; a gas source (505) configured to supply gas to the second coupler at a pressure that alternates between a first pressure and a second pressure that is at least about 1.45 PSI (9,997 Pa) greater than the first pressure at a frequency of about 0.1 Hz to about 10 Hz; 10. The cleaning system of claim 1, further comprising:

7. The gas source is a pneumatically driven venturi (506) configured to deliver gas at approximately 2-3 inHg (6,772.78-10,159.2 Pa); 7. The cleaning system of claim 6, comprising:

8. 7. The purification system of claim 6, wherein the first pressure is less than ambient atmospheric pressure and the second pressure is greater than ambient atmospheric pressure.

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