X-ray irradiation system and method for x-ray irradiation

Abstract

To provide an X-ray irradiation system which can irradiate fluid with an X-ray continuously and uniformly with a relatively simple configuration.SOLUTION: The X-ray irradiation system for irradiating fluid with an X-ray includes: an X-ray device for emitting an X-ray; a placement board having a flat placement unit and a holding unit for holding the X-ray device in the upper part of the placement unit in a vertical direction so that the placement unit is irradiated with the X-ray; and a columnar flow passage having a predetermined length in a uniform and predetermined hollow cross section. The columnar flow passage is placed on a predetermined area of the placement unit and the amount of irradiating a liquid medium flowing in the columnar flow passage with an X-ray can be controlled according to the predetermined size.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a configuration of an X-ray irradiation system that irradiates a fluid with X-rays and an irradiation method thereof, and more particularly to a technique that is effective when applied to an X-ray irradiation system that is required to irradiate a fluid with X-rays continuously and uniformly. [Background technology]

[0002] One of the uses of X-ray devices is as an X-ray irradiation device for experimental and research purposes that targets animals and plants. In such X-ray irradiation devices, X-rays are irradiated onto cultured cells, microorganisms, plants, etc. For example, they are used for the purpose of inactivating biological materials such as cells by irradiating them with X-rays.

[0003] Background art in this technical field includes, for example, technology such as that described in Patent Document 1. Patent Document 1 discloses "a blood bag radiation irradiation device capable of uniformly irradiating the blood in the blood bags by placing multiple blood bags on a turntable and irradiating them with X-rays." [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 10-274699 Summary of the Invention [Problem to be solved by the invention]

[0005] Incidentally, in order to irradiate a biological material such as a cell with X-rays and totally inactivate the biological material, it is necessary to irradiate the biological material with X-rays continuously and uniformly.

[0006] One possible method for continuously and uniformly irradiating biological material with X-rays is to mix the biological material in a liquid medium, flow the liquid medium at a predetermined speed through a cylindrical flow passage consisting of a cylindrical tube having a uniform, predetermined cross-sectional area, and irradiate the liquid medium with X-rays.

[0007] However, simply making the columnar flow passages straight and flowing a liquid medium through them is not practical because it would require a long distance to inactivate the biological material.

[0008] By using the turntable described in the above Patent Document 1, the first group of blood placed on the turntable can be uniformly irradiated with radiation by rotating the turntable a predetermined number of times.

[0009] However, when the second group of blood bags is to be treated, the rotation of the turntable must be stopped, the first group of blood bags must be removed from the turntable, and the second group of blood bags must be placed on the turntable, which is not appropriate when treating a large amount of blood with radiation.

[0010] SUMMARY OF THE PRESENT DISCLOSURE An object of the present invention is to provide an X-ray irradiation system and an X-ray irradiation method that can irradiate a fluid with X-rays continuously and uniformly with a relatively simple configuration. [Means for solving the problem]

[0011] In order to solve the above problems, the present invention provides an X-ray irradiation system for irradiating X-rays to a fluid, the system comprising: an X-ray device for emitting X-rays; a mounting table including a planar mounting section and a holding section for holding the X-ray device vertically above the mounting section so as to irradiate the X-rays to the mounting section; and a columnar flow passage having a predetermined length and a uniform predetermined hollow cross-section, the columnar flow passage being mounted on the mounting section in a planar manner with a predetermined area, and the amount of X-ray irradiation to a liquid medium flowing through the columnar flow passage being controlled by the size of the predetermined area.

[0012] The present invention also provides an X-ray irradiation method for irradiating a fluid with X-rays, comprising: (a) an X-ray irradiation step of placing a spiral flow path formed by spirally rotating a columnar flow passage having a predetermined length and a uniform predetermined cross-section a predetermined number of times on a flat surface, and continuously irradiating the X-rays over an entire flow area indicating a section starting from a starting end set at a predetermined position of the spiral flow path and ending at a terminal end; (b) a fluid supply step of connecting an outlet of a supply pump connected to an accumulation device that accumulates the fluid to an intake port at one end of the spiral flow path for sucking in the fluid, thereby continuously supplying the fluid to the spiral flow path without creating any gaps in the cross section; (c) a fluid recovery step of connecting a recovery device to an outlet at the other end of the spiral flow path different from the intake port, and recovering the fluid that flows through and is discharged through the spiral flow path; and (d) a stopping step of stopping the irradiation of the X-rays to the flow area after the rear end, indicating the rearmost part of the fluid, has passed the terminal end. Effect of the Invention

[0013] According to the present invention, it is possible to realize an X-ray irradiation system and an X-ray irradiation method that can irradiate a fluid with X-rays continuously and uniformly with a relatively simple configuration.

[0014] This makes it possible to uniformize the energy of the X-rays irradiated onto the fluid, and, for example, makes it possible to uniformly inactivate biological material, such as cells, that is mixed into the fluid.

[0015] Problems, configurations and effects other than those described above will become apparent from the following description of the embodiments. [Brief description of the drawings]

[0016] [Figure 1] 1 is a diagram showing a schematic configuration of an X-ray irradiation system according to a first embodiment of the present invention. [Diagram 2] 2 is a diagram showing the X-ray device 1 of FIG. 1 and an X-ray irradiation range. [Diagram 3] FIG. 2 is a plan view showing the spiral channel 3 of FIG. [Figure 4A]1 is a diagram showing a state in which a sample fluid 23 passes through a spiral channel 3. FIG. [Figure 4B] 1 is a diagram showing a state in which a sample fluid 23 passes through a spiral channel 3. FIG. [Diagram 5] 3 is a flowchart showing an X-ray irradiation method according to the first embodiment of the present invention. [Figure 6] FIG. 6 is a plan view showing a spiral passage 3 according to a second embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In the drawings, the same components are designated by the same reference numerals, and detailed description of overlapping parts will be omitted.

[0018] In addition, in this specification, the emission of X-rays from an X-ray device (X-ray source) is called "emission," as opposed to "irradiation," which refers to the application of X-rays to an object. EXAMPLES

[0019] First Embodiment An X-ray irradiation system and an X-ray irradiation method according to a first embodiment of the present invention will be described with reference to FIGS.

[0020] FIG. 1 is a diagram showing a schematic configuration of an X-ray irradiation system according to this embodiment.

[0021] The X-ray irradiation system of the present invention aims to irradiate a fluid with X-rays continuously and uninterruptedly, thereby making the X-ray energy imparted to the fluid uniform.

[0022] As shown in FIG. 1, the X-ray irradiation system of this embodiment mainly comprises an X-ray device 1 that emits X-rays, a mounting table 2, a spiral flow path 3, a supply device 4 that supplies a fluid, a recovery device 5 that recovers the fluid, and a control unit 6.

[0023] The mounting table 2 includes a planar mounting portion 7 and a holder 9 that holds the X-ray device 1 vertically above the mounting portion 7 so as to irradiate the mounting portion 7 with X-rays 8.

[0024] The spiral flow path 3 is formed by winding a columnar flow passage having a predetermined length with a uniform predetermined hollow cross section a predetermined number of times in a spiral shape, and is placed on the placement part 7. The columnar shape may be a cylinder or a prism, but a cylinder is easier to process.

[0025] The supply device 4 includes an accumulation device 10 that accumulates the fluid, and a supply pump 11 that supplies the fluid from the accumulation device 10 to the spiral flow path 3 at a predetermined protruding pressure, and accumulates and supplies the fluid. The protruding pressure of the supply pump 11 is set so as to supply the fluid without creating any gaps in the hollow cross section of the spiral flow path 3.

[0026] The control unit 6 controls the ON / OFF of the X-ray device 1 and the emission amount of the X-rays 8 , and also controls the ON / OFF of the supply pump 11 .

[0027] One end of the spiral passage 3 is connected as a suction port 12 to a supply pump 11 , and fluid is supplied from the accumulation device 10 to the spiral passage 3 via the supply pump 11 .

[0028] The other end of the spiral channel 3 is connected to a recovery device 5 as a discharge port 13 , and the fluid is recovered from the spiral channel 3 to the recovery device 5 .

[0029] FIG. 2 is a diagram showing the X-ray device 1 of FIG. 1 and its X-ray irradiation range.

[0030] As shown in FIG. 2, in the X-ray device 1 of this embodiment, the shape and size of the X-ray irradiation range of the X-rays 8 emitted from the anode 20 can be set by the shape and area of ​​the irradiation port 21 provided in a part of the shielding cover 14.

[0031] In the structure of this system, the size of the X-ray irradiation range can be adjusted by the height of the holding part 9 and the size of the irradiation port 21. However, increasing the height of the holding part 9 affects the energy of the irradiated X-rays 8, so the holding part 9 is fixed in a certain position and the size of the X-ray irradiation range is set by adjusting the shape and area of ​​the irradiation port 21.

[0032] Fig. 3 is a plan view showing the spiral channel 3 in Fig. 1. As an example of the X-ray irradiation range, the start end and end end are set inside the intake port 12 and exhaust port 13.

[0033] 3, a start end and a terminal end are set in the spiral flow path 3, and the range of flow from the start end to the terminal end is set as the flow region. The start end is set at the same position as the suction port 12, or is set behind (downstream) the flow direction indicating the direction in which the fluid 22 flows relative to the suction port 12 and ahead (upstream) of the terminal end in the flow direction, and the terminal end is set at the same position as the discharge port 13, or is set ahead (upstream) of the discharge port 13 in the flow direction.

[0034] That is, the columnar flow passages are arranged in a planar manner within a predetermined range. A liquid medium is caused to flow through the planarly arranged columnar flow passages at a predetermined speed and is irradiated with X-rays, and the biological material is inactivated while a predetermined amount of the liquid medium flows through the planarly arranged columnar flow passages. The size of the planar range is set so that the entire amount of the predetermined amount of biological material within that range is inactivated.

[0035] The planar shape is a circle or a spiral shape such as an ellipse in which the ratio of the major axis to the minor axis is not extremely large. In other words, a spiral flow passage is formed from columnar flow passages having a uniform, predetermined cross-sectional area. When arranging the columnar flow passages in a planar shape, it is possible to make them sawtooth-shaped, but in this case, it is not practical because it is not easy to process the columnar flow passages and there are problems with the durability of the bent parts. Therefore, in the present invention, a spiral flow passage is arranged in a planar shape.

[0036] The number of revolutions of the spiral flow passage is set as follows: The number of revolutions of the spiral flow passage is set so that the entire amount of biological material is inactivated while the liquid medium containing a predetermined amount of biological material is circulating through the spiral flow passage. If the predetermined amount of biological material is large, the number of revolutions of the spiral flow passage is increased, and if the predetermined amount of biological material is small, the number of revolutions of the spiral flow passage is decreased.

[0037] Another method is to adjust the cross-sectional area of ​​the vortex flow passage. However, care must be taken not to increase the cross-sectional area of ​​the vortex flow passage to significantly affect the amount of X-ray transmission. If the cross-sectional area of ​​the vortex flow passage is increased, the attenuation of X-rays increases, resulting in a smaller amount of transmission.

[0038] In this way, the present invention makes it possible to control the amount of X-ray irradiation to the liquid medium and contaminants by the number of revolutions of the vortex flow passage, i.e., the X-ray irradiation range indicating the planar size of the arrangement of the vortex flow passage, and the cross-sectional area of ​​the vortex flow passage.

[0039] With the above-mentioned configuration, in the X-ray irradiation system of this embodiment, the fluid 22 flowing through the flow area in the spiral flow channel 3 is irradiated with X-rays 8 as follows.

[0040] The desired amount of the desired fluid 22 is stored in the storage device 10 within the supply device 4 .

[0041] Next, the X-ray device 1 is turned on in response to a command from the control unit 6 to emit X-rays 8 at a predetermined energy, and the flow area of ​​the spiral flow path 3 is irradiated with the X-rays 8 .

[0042] Next, the supply pump 11 in the supply device 4 is turned on in response to a command from the control unit 6, and the fluid 22 is supplied to the spiral flow path 3 at a predetermined protruding pressure.

[0043] X-rays 8 emitted from the X-ray device 1 are irradiated continuously and uninterruptedly into the flow area until the rear end portion, which indicates the rearmost portion of the fluid 22, passes through the terminal end portion.

[0044] By the above operations, the fluid 22 flowing through the flow area is uniformly irradiated with X-rays 8. Note that "uniform" means that the entire fluid is irradiated with the same amount of X-rays as much as possible, with some tolerance for error. After the fluid 22 passes through the end portion, the X-ray irradiated fluid 22 is collected in the collection device 5.

[0045] In order to irradiate the entire fluid with X-rays 8 uniformly, it is necessary to start irradiating the flow area with X-rays 8 before the leading end, which indicates the most forward part of the fluid 22, passes through the starting end. In the X-ray irradiation system of this embodiment, the flow area is irradiated with X-rays 8 before the supply of the fluid 22 from the supply device 4 starts, because this is advantageous in terms of cost. As another method, a sensor may be disposed between the intake port 12 and the starting end, the supply of the fluid 22 is detected by the sensor, and the irradiation of the X-rays 8 is started using the signal as a trigger, but this requires the cost of disposing the sensor and the cost of creating software that acquires the sensor signal and turns on the X-ray device 1, which is disadvantageous in terms of cost.

[0046] 4A and 4B are diagrams showing the passage of the sample fluid 23 through the spiral channel 3. FIG.

[0047] The setting of irradiation conditions for the X-rays 8 will be described with reference to FIGS. 4A and 4B.

[0048] In the X-ray irradiation system of this embodiment, in a test operation prior to the actual operation, a sample fluid 23 is prepared by mixing a biological material such as cells to be used in the actual operation with an arbitrarily set amount of fluid. The entire amount of this sample fluid 23 is continuously supplied from the supply device 4 to the spiral channel 3.

[0049] The X-ray emission output of the X-ray device 1, the length of the columnar flow passage of the spiral flow channel 3, the number of revolutions of the spiral flow channel 3, the size of the hollow cross-section of the spiral flow channel 3, and the protruding pressure of the supply pump 11 are set so that the biological material contained in the sample fluid 23 is uniformly inactivated between the time when the leading end 24 of the sample fluid 23 passes the starting end and the time when the trailing end 25 of the sample fluid 23 passes the ending end.

[0050] Specifically, the values ​​of the respective irradiation conditions are set according to the following procedure.

[0051] (1) A total amount of sample fluid 23, Q, is prepared by storing it in storage device 10 in supply device 4.

[0052] (2) Based on past experience, a columnar flow passage having a cavity cross-sectional size and length deemed appropriate for the biological material to be used is spirally wound a predetermined number of times to prepare a spiral flow passage 3, and then set on the mounting section 7.

[0053] (3) Set the X-ray emission output of the X-ray device 1.

[0054] (4) The protruding pressure of the supply pump 11 is set so that no gaps are generated in the cross section of the cavity when the sample fluid 23 is circulated through the spiral flow path 3.

[0055] (5) In response to a command from the control unit 6, the X-ray device 1 is turned on to start irradiating the circulation area with X-rays 8.

[0056] (6) In response to a command from the control unit 6, the supply pump 11 in the supply device 4 is turned on to continuously supply the entire amount Q of the sample fluid 23 from the supply device 4 to the spiral channel 3.

[0057] (7) X-rays 8 are irradiated continuously and uninterruptedly into the flow area until the rear end 25 of the sample fluid 23 passes through the terminal end of the spiral channel 3 .

[0058] (8) When the entire amount Q of the sample fluid 23 has been collected by the collection device 5, it is confirmed whether the biological material contained in the sample fluid 23 has been uniformly inactivated. The confirmation method is appropriately selected according to the type of biological material contained in the sample fluid 23.

[0059] When it is confirmed that the biological material has been uniformly inactivated, the X-ray emission output of the X-ray device 1, the length of the columnar flow passage, the number of revolutions of the spiral flow passage 3, the size of the cavity cross section, and the protruding pressure of the supply pump 11, which were set in the above steps (1) to (8), are used in this operation.

[0060] If the biological material is not uniformly inactivated, change all or some of the values ​​of the X-ray emission power of the X-ray device 1, the length of the columnar flow passage, the number of revolutions of the spiral flow passage 3, the size of the cavity cross section, and the protruding pressure of the supply pump 11, and repeat steps (1) to (8) above to find values ​​that uniformly inactivate the biological material.

[0061] The height of the holder 9 may be set according to conditions such as the environment of the place where the X-ray irradiation system is installed and the size of a shielding device (not shown) that shields the X-ray device 1.

[0062] FIG. 5 is a flowchart showing an X-ray irradiation method of this embodiment using the X-ray irradiation system of FIG.

[0063] First, in the X-ray irradiation step S1, a spiral flow path 3, which is formed by winding a columnar flow passage having a predetermined length and a uniform hollow cross-section in a spiral pattern a predetermined number of times, is placed on a flat surface (mounting portion 7), and X-rays 8 are continuously irradiated over the entire flow area indicating the section starting from the starting end set at a predetermined position of the spiral flow path 3 and ending at the ending end.

[0064] Next, in the fluid supply step S2, the outlet of a supply pump 11 connected to an accumulation device 10 that accumulates the fluid 22 is connected to an intake port 12 that sucks in the fluid 22 at one end of the spiral flow path 3, so that the fluid 22 is continuously supplied to the spiral flow path 3 without creating any gaps in the hollow cross section of the spiral flow path 3.

[0065] By carrying out the steps up to this point, it becomes possible to uniformly irradiate the fluid 22 flowing through the flow area in the spiral flow path 3 with the X-rays 8.

[0066] Next, in the fluid recovery step S3, a recovery device 5 is connected to the discharge port 13 that discharges the fluid 22 at the other end of the spiral channel 3 different from the intake port 12, and the fluid 22 that flows through the spiral channel 3 and is discharged is recovered.

[0067] In this step, the fluid 22 irradiated with the X-rays 8 is collected.

[0068] Finally, in the stopping (termination) step, after the rear end portion indicating the rearmost portion of the fluid 22 passes through the terminal end portion of the spiral channel 3, the irradiation of the X-rays 8 to the flow area is stopped.

[0069] The X-ray emission power, the length of the columnar flow passage, the number of revolutions of the spiral flow passage 3, the size of the cavity cross section, and the specified protruding pressure of the supply pump 11 are set in the flow area setting step S0, which is a step prior to the X-ray irradiation step S1.

[0070] Specifically, the entire amount of sample fluid 23, which is an arbitrarily set amount of fluid 22 mixed with biological materials such as cells to be used in this operation, is continuously supplied from supply device 4 to spiral channel 3, and the X-ray emission output of X-ray device 1, the length of the columnar flow passage, the number of revolutions of spiral channel 3, the size of the cavity cross-section, and the protruding pressure of supply pump 11 are set so that the biological materials contained in sample fluid 23 are uniformly inactivated between the time when the leading end 24 in the flow direction of sample fluid 23 passes the starting end of spiral channel 3 and the time when the rear end 25 of sample fluid 23 passes the terminal end of spiral channel 3.

[0071] The start end and the end end of the spiral flow passage 3 are set in the flow area setting step S0 as follows: The start end is set at the same position as the suction port 12, or is set behind (downstream) the flow direction indicating the direction in which the fluid 22 flows relative to the suction port 12 and ahead (upstream) of the end end in the flow direction; the end end is set at the same position as the discharge port 13, or is set ahead (upstream) of the discharge port 13 in the flow direction.

[0072] As described above, the X-ray irradiation system of this embodiment includes the X-ray device 1 that emits X-rays 8, the planar mounting section 7, and the mounting table 2 that includes the holder 9 that holds the X-ray device 1 vertically above the mounting section 7 so as to irradiate the mounting section 7 with X-rays 8, and a columnar flow passage having a predetermined length and a uniform, predetermined hollow cross-section. The columnar flow passage is placed on the mounting section 7 in a planar manner with a predetermined area, and the amount of X-ray irradiation to the liquid medium flowing through the columnar flow passage is controlled based on the predetermined area.

[0073] Then, the columnar flow passage is wound in a spiral shape a predetermined number of times so that there is a gap (space) between adjacent columnar flow passages, or so that adjacent columnar flow passages come into contact with each other, as will be described later in Example 2 (FIG. 6), to form a spiral flow passage 3, and the spiral flow passage 3 is arranged so that its center is located below the X-ray irradiation unit of the X-ray device 1. X-rays 8 are irradiated to a flow area indicating a section starting from a starting end set at a predetermined position of the spiral flow passage 3 and ending at an ending end.

[0074] This allows the fluid 22 to be irradiated with the X-rays 8 continuously and uniformly.

[0075] In addition, a sensor for measuring the amount of X-rays transmitted through the spiral flow path 3 may be provided on the mounting table 2, and the amount of transmitted X-rays may be measured using this sensor. If a deviation of a predetermined amount or more occurs between the reference value and the measured value, the output of the X-ray device 1 may be adjusted so that the deviation is reduced to zero. EXAMPLES

[0076] Second Embodiment With reference to FIG. 6, an X-ray irradiation system according to a second embodiment of the present invention will be described.

[0077] FIG. 6 is a plan view showing the spiral passage 3 of the present embodiment.

[0078] In Example 1 (FIG. 3), the columnar flow passages constituting the spiral flow passage 3 are arranged with a gap (space) between adjacent columnar flow passages, whereas in this Example (FIG. 6), adjacent columnar flow passages are arranged in close contact with each other without any gaps, which is different from Example 1 (FIG. 3). The other configurations are the same as those of Example 1 (FIG. 3).

[0079] As in the present embodiment (FIG. 6), by making adjacent columnar flow passages close to each other with no gaps between them, the number of times the columnar flow passages make turns within the same surface area can be increased, and the fluid 22 can be irradiated with X-rays 8 for a longer period of time than in the first embodiment (FIG. 3).

[0080] As a result, biological materials such as cells that are mixed into the fluid 22 can be inactivated more reliably.

[0081] Furthermore, the present invention is not limited to the above-mentioned embodiment, and various modifications are included. For example, the above-mentioned embodiment has been described in detail to clearly explain the present invention, and is not necessarily limited to those having all of the configurations described. Furthermore, it is possible to replace a part of the configuration of one embodiment with the configuration of another embodiment, and it is also possible to add the configuration of another embodiment to the configuration of one embodiment. Furthermore, it is possible to add, delete, or replace a part of the configuration of each embodiment with another configuration. [Explanation of symbols]

[0082] 1...X-ray device, 2...mounting table, 3...swirl flow path, 4...supply device, 5...recovery device, 6...control unit, 7...mounting unit, 8...X-ray, 9...holding unit, 10...storage device, 11...supply pump, 12...inlet, 13...outlet, 14...shielding cover, 15...X-ray tube, 16...filament, 17...cathode, 18...thermoelectrons, 19...target (tungsten), 20...anode, 21...irradiation port, 22...fluid, 23...sample fluid, 24...tip, 25...rear end.

Claims

1. An X-ray irradiation system for irradiating a fluid with X-rays, comprising: An X-ray device that emits X-rays; a mounting table including a planar mounting portion and a holder that holds the X-ray device vertically above the mounting portion so as to irradiate the X-rays onto the mounting portion; a columnar flow passage having a predetermined length and a uniform predetermined cavity cross-section; an X-ray irradiation system comprising: the columnar flow passage is placed on the placement portion in a planar manner with a predetermined area; and an amount of X-ray irradiation to a liquid medium flowing through the columnar flow passage is controlled based on the size of the predetermined area.

2. 2. The X-ray irradiation system according to claim 1, The columnar flow passage is wound in a spiral shape a predetermined number of times so that adjacent columnar flow passages come into contact with each other to form a spiral flow passage; a center portion of the spiral flow passage is disposed below an X-ray irradiation portion of the X-ray device; An X-ray irradiation system characterized in that the X-rays are irradiated to a flow area indicating a section starting from a starting end set at a predetermined position of the spiral flow path and ending at a terminal end.

3. 3. The X-ray irradiation system according to claim 2, a supply device connected to an intake port at one end of the spiral flow path for sucking in the fluid and supplying the fluid to the spiral flow path; a control device for controlling the X-ray device and the supply device, The control device starts irradiating the X-rays from the X-ray device to the flow area before starting to supply the fluid from the supply device to the spiral flow path, and continuously irradiates the X-rays to the flow area until the supply of the fluid from the supply device to the spiral flow path is completed and all of the fluid present in the flow area is discharged.

4. 4. The X-ray irradiation system according to claim 3, The supply device includes an accumulation device for accumulating the fluid; a supply pump having an outlet connected to the inlet for supplying the fluid from the accumulator to the spiral flow passage at a predetermined outlet pressure; An X-ray irradiation system, comprising: a first passage for supplying said fluid to said spiral passage continuously without creating any gaps in said cross section of said cavity.

5. 5. The X-ray irradiation system according to claim 4, an X-ray irradiation system characterized in that, in a test operation prior to actual operation of the X-ray irradiation system, a total amount of sample fluid, in which an arbitrarily set amount of the fluid is mixed with a biological material to be used in actual operation, is continuously supplied from the supply device to the spiral channel, and the X-ray emission output of the X-ray device, the length of the columnar flow passage, the number of revolutions of the spiral channel, the size of the hollow cross-section, and the specified protruding pressure of the supply pump are set so that the biological material present in the sample fluid is uniformly inactivated during the period from when the leading end of the sample fluid in the flow direction passes through the starting end to when the trailing end of the sample fluid in the flow direction passes through the terminal end.

6. 4. The X-ray irradiation system according to claim 3, An X-ray irradiation system comprising: a recovery device connected to an outlet that discharges the fluid at the other end of the spiral flow path different from the intake port, and recovering the fluid that flows through the spiral flow path and is discharged.

7. 7. The X-ray irradiation system according to claim 6, an X-ray irradiation system characterized in that the starting end is set at the same position as the intake port, or at a rear side of the flow direction indicating the direction in which the fluid flows relative to the intake port and forward of the terminal end in the flow direction, and the terminal end is set at the same position as the exhaust port, or at a forward side of the exhaust port in the flow direction.

8. 2. The X-ray irradiation system according to claim 1, The columnar flow passage is wound in a spiral shape a predetermined number of times with a gap between adjacent columnar flow passages to form a spiral flow passage; a center portion of the spiral flow passage is disposed below an X-ray irradiation portion of the X-ray device; An X-ray irradiation system characterized in that the X-rays are irradiated to a flow area indicating a section starting from a starting end set at a predetermined position of the spiral flow path and ending at a terminal end.

9. 2. The X-ray irradiation system according to claim 1, An X-ray irradiation system characterized in that the amount of transmitted X-rays is measured using a sensor arranged on the mounting table for measuring the amount of transmitted X-rays, and when a deviation of a predetermined amount or more occurs between a reference value and a measured value, the output of the X-ray device is adjusted so that the deviation is set to zero.

10. 1. An X-ray irradiation method for irradiating a fluid with X-rays, comprising: (a) an X-ray irradiation step of placing a spiral flow path formed by winding a columnar flow path having a uniform, predetermined hollow cross section and a predetermined length in a spiral pattern a predetermined number of times on a flat surface, and continuously irradiating the X-rays over an entire flow area indicating a section starting from a starting end and ending at a terminal end set at a predetermined position of the spiral flow path; (b) a fluid supply step of continuously supplying the fluid to the spiral passage without creating any gap in the cross section of the cavity by connecting an outlet of a supply pump connected to an accumulating device for accumulating the fluid to an intake port at one end of the spiral passage for sucking the fluid; (c) a fluid recovery step of connecting a recovery device to an outlet that discharges the fluid at the other end of the spiral flow path different from the suction port, and recovering the fluid that flows through the spiral flow path and is discharged; (d) a stopping step of stopping the irradiation of the X-rays to the flow area after a rear end portion indicating a rearmost portion of the fluid has passed through the terminal portion; 1. An X-ray irradiation method comprising the steps of:

11. The X-ray irradiation method according to claim 10, an X-ray irradiation method characterized by including, prior to the step (a), a test operation step (e) of continuously supplying from a supply device to the spiral flow path a total amount of sample fluid in which an arbitrarily set amount of the fluid has been mixed with a biological material to be used in this operation, and setting the X-ray emission output of the X-ray device, the length of the columnar flow path, the number of revolutions of the spiral flow path, the size of the cross section of the cavity, and a predetermined protruding pressure of the supply pump so that the biological material present in the sample fluid is uniformly inactivated during the period from when the leading end of the sample fluid in the flow direction passes through the starting end to when the trailing end of the sample fluid in the flow direction passes through the ending end.

12. The X-ray irradiation method according to claim 10, an X-ray irradiation method characterized by including, prior to step (a), a flow area setting step of setting the starting end at the same position as the intake port, or at a position behind the intake port in a flow direction indicating the direction in which the fluid flows and forward of the terminal end in the flow direction, and setting the terminal end at the same position as the exhaust port, or at a position forward of the exhaust port in the flow direction.

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