Tablet-form cleanser for oral appliances

Abstract

To provide a tablet-form cleanser for oral appliances containing cyclodextrin, with resistance to hardness reduction.SOLUTION: A tablet-form cleanser for oral appliances disclosed herein comprises (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) cyclodextrin, and (D) an α-olefin sulfonate.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present disclosure relates to a tablet-shaped oral instrument cleanser that contains cyclodextrin but exhibits reduced hardness reduction. [Background technology]

[0002] Dentures and other oral appliances are prone to bacteria, biofilms, and other deposits, and if left uncleaned, they can cause bad breath and may even contribute to oral diseases such as periodontal disease. Therefore, as part of oral care, it is essential to clean and keep oral appliances clean. Since bacteria and dirt adhering to oral appliances cannot be sufficiently removed by cleaning with a brush, cleaning with a detergent is important.

[0003] Cleaning of intraoral instruments with a detergent is generally performed by immersing the intraoral instruments in cleaning water prepared by adding the detergent to water. Conventionally, detergents for intraoral instruments have been formulated with surfactants and foaming agents (carbonic acid and acid), and are designed to enhance the cleaning effect by exerting chemical cleaning power due to surface activation and physical cleaning power due to foaming action when added to water.

[0004] In addition, in order to impart a bleaching effect and improve cleaning and deodorizing power, a bleaching agent is generally blended in an intraoral instrument cleaner. For example, Patent Document 1 proposes a denture cleaner containing an oxygen-based bleaching agent. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2005-272365 A Summary of the Invention [Problem to be solved by the invention]

[0006] However, the formulation technology of blending a bleaching agent into an intraoral instrument cleanser has limitations in terms of improving the deodorizing power of the intraoral instrument cleanser. Also, from the viewpoint of expanding the variety of intraoral instrument cleansers, the development of a new formulation technology for improving the deodorizing power of intraoral instrument cleansers has been required.

[0007] The present inventors have investigated new formulation technologies for improving the deodorizing power of intraoral instrument cleansers and have found that the deodorizing power of the intraoral instrument cleansers can be improved by adding cyclodextrin to the intraoral instrument cleansers.

[0008] However, when cyclodextrin was added to an intraoral instrument cleanser containing a foaming agent (carbonate and acid), a new problem was encountered in that when the intraoral instrument cleanser was molded into tablets, sufficient hardness was not obtained, making the tablets prone to chipping or cracking even with a slight impact.

[0009] An object of the present disclosure is to provide a tablet-shaped oral instrument cleanser that contains cyclodextrin but exhibits reduced hardness reduction. [Means for solving the problem]

[0010] The present inventors have conducted extensive research to solve the above problems, and have unexpectedly found that by incorporating α-olefin sulfonate together with cyclodextrin into an intraoral instrument cleaner containing a foaming agent (carbonic acid and acid), the decrease in tablet hardness is suppressed when the intraoral instrument cleaner is molded into a tablet. The present disclosure has been completed based on this finding and through further research.

[0011] That is, the present disclosure provides the inventions of the following aspects. Item 1. A tablet-shaped intraoral instrument cleanser comprising: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) a cyclodextrin; and (D) an α-olefin sulfonate. Item 2. The tablet-shaped intraoral instrument cleaner according to Item 1, further comprising (E) an oxygen bleaching agent. Item 3. The tablet-form intraoral instrument cleanser according to Item 2, wherein the oxygen bleaching agent is at least one selected from the group consisting of monopersulfate and perborate. Item 4. The tablet-shaped intraoral instrument cleanser according to Item 2, further comprising (F) a bleaching activator. Item 5. The tablet-form intraoral instrument cleanser according to Item 4, wherein the bleaching activator is tetraacetylethylenediamine. Item 6. The tablet-form intraoral instrument cleanser according to any one of Items 1 to 5, which is a denture cleanser. Item 7. A method for producing a tablet-form intraoral instrument cleanser, comprising subjecting a raw material mixture containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) a cyclodextrin, and (D) an α-olefin sulfonate to a tableting step. Item 8. Use of a composition comprising (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) a cyclodextrin, and (D) an α-olefin sulfonate, for cleaning an intraoral appliance. Item 9. Use of a composition comprising (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) a cyclodextrin, and (D) an α-olefin sulfonate, as a tablet-shaped intraoral instrument cleanser. Item 10. A method for cleaning an intraoral instrument, comprising immersing an intraoral instrument in water containing a tablet-shaped intraoral instrument cleaner comprising: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) a cyclodextrin; and (D) an α-olefin sulfonate. Effect of the Invention

[0012] The tablet-shaped intraoral instrument cleanser of the present disclosure contains cyclodextrin, but also contains α-olefin sulfonate, which suppresses the decrease in tablet hardness, and therefore can effectively prevent the tablet from being chipped or cracked due to a slight impact during transportation, etc. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] In this specification, the notation X to Y regarding a numerical range means that the range is from X to Y.

[0014] In this specification, the term "oral appliance" refers to a dental appliance that needs to be worn and removed in the oral cavity, such as a complete denture, a partial denture, an orthodontic appliance, a retainer, and a mouthpiece.

[0015] 1. Mouth instrument cleaner The tablet-shaped intraoral instrument cleaner of the present disclosure (hereinafter, also simply referred to as "intraoral instrument cleaner") is characterized by containing (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates (hereinafter, sometimes referred to as component (A)), (B) acid (hereinafter, sometimes referred to as component (B)), (C) cyclodextrin (hereinafter, sometimes referred to as component (C)), and (D) α-olefin sulfonate (hereinafter, sometimes referred to as component (D)). The intraoral instrument cleaner of the present disclosure will be described in detail below.

[0016] [Carbonate compounds] The intraoral instrument cleanser of the present disclosure contains, as component (A), at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates. The carbonate compound is a known component constituting a foaming agent for intraoral instrument cleansers.

[0017] The carbonate salt is not particularly limited, but may be, for example, an alkali metal salt of carbonic acid such as sodium carbonate or potassium carbonate, preferably sodium carbonate. The hydrogen carbonate salt is not particularly limited, but may be, for example, an alkali metal salt of hydrogen carbonate such as sodium hydrogen carbonate or potassium hydrogen carbonate, preferably sodium hydrogen carbonate. The double salt of carbonate and hydrogen carbonate is not particularly limited, but may be, for example, sodium sesquicarbonate. The above-mentioned carbonate compounds may be used alone or in combination of two or more.

[0018] In the intra-oral instrument cleanser of the present disclosure, the content of component (A) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intra-oral instruments, and can be, for example, 1 to 50% by weight, preferably 3 to 45% by weight, and more preferably 5 to 40% by weight.

[0019] [acid] The intraoral instrument cleanser of the present disclosure contains an acid as component (B). The acid is a component known to be a component constituting a foaming agent for intraoral instrument cleansers.

[0020] The acid may be an organic acid or an inorganic acid, preferably an organic acid. The organic acid may be, but is not particularly limited to, citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, etc., preferably citric acid. The inorganic acid may be, but is not particularly limited to, phosphoric acid, sulfamic acid, etc. The above-mentioned exemplified acids may be used alone or in combination of two or more.

[0021] In the intra-oral instrument cleanser of the present disclosure, the content of component (B) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intra-oral instruments, and can be, for example, 1 to 60% by weight, preferably 3 to 40% by weight, and more preferably 5 to 20% by weight.

[0022] In the intra-oral instrument cleanser of the present disclosure, the content of component (B) is not particularly limited, provided that it can react with component (A) in water to generate carbon dioxide. The content of component (B) per 100 parts by weight of component (A) is, for example, 10 to 300 parts by weight, preferably 20 to 200 parts by weight, and more preferably 30 to 100 parts by weight.

[0023] [Cyclodextrin] The intraoral instrument cleaner of the present disclosure contains cyclodextrin as component (C). In the intraoral instrument cleaner of the present disclosure, cyclodextrin is a component for imparting excellent deodorizing power. Since cyclodextrin has an encapsulating function, it is considered that the deodorizing power is improved by encapsulating malodorous components in the intraoral instrument cleaner water prepared by adding the intraoral instrument cleaner of the present disclosure to water.

[0024] The cyclodextrin is not particularly limited, and examples thereof include those having 5 or more glucose atoms bound thereto, specifically, α-cyclodextrin having 6 glucose atoms bound thereto, β-cyclodextrin having 7 glucose atoms bound thereto, and γ-cyclodextrin having 8 glucose atoms bound thereto, etc. The cyclodextrins exemplified above may be used alone or in combination of two or more kinds.

[0025] In one embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use α-, β-, or γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. In another embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use any two kinds selected from the group consisting of α-, β-, and γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. In another embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use three kinds of α-, β-, and γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. When α-, β-, and γ-cyclodextrin are used, the weight ratios of α-, β-, and γ-cyclodextrin are not particularly limited, but from the viewpoint of further improving the deodorizing power, when the total amount of α-, β-, and γ-cyclodextrin is taken as 100 parts by weight, the content of α-cyclodextrin is preferably 20 to 40 parts by weight, and more preferably 25 to 35 parts by weight, the content of β-cyclodextrin is preferably 35 to 70 parts by weight, and more preferably 45 to 60 parts by weight, and the content of γ-cyclodextrin is preferably 10 to 25 parts by weight, and more preferably 15 to 20 parts by weight.

[0026] In the intraoral instrument cleanser of the present disclosure, the content of component (C) may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.01 to 20% by weight, and from the viewpoint of further improving the deodorizing power, the content is preferably 0.1 to 15% by weight, more preferably 0.5 to 10% by weight, and even more preferably 0.8 to 8% by weight.

[0027] [α-Olefin sulfonate] The intraoral instrument cleaner of the present disclosure contains an α-olefin sulfonate as component (D). In the intraoral instrument cleaner of the present disclosure, the α-olefin sulfonate is a component for suppressing a decrease in tablet hardness when the intraoral instrument cleaner for tablets containing cyclodextrin is formed into a tablet. The α-olefin sulfonate also serves as an anionic surfactant and as a component for exerting a chemical cleaning effect.

[0028] The α-olefin sulfonate may be any salt commonly used in intraoral instrument cleaners, and may be, but is not limited to, an α-olefin sulfonate having an average of 8 to 22 carbon atoms, preferably an average of 10 to 20 carbon atoms, more preferably an average of 12 to 18 carbon atoms, and even more preferably an average of 14 to 16 carbon atoms in one molecule. Examples of the salt form include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochloride, and are preferably alkali metal salts, and more preferably sodium salts.

[0029] In the intra-oral instrument cleanser of the present disclosure, the content of component (D) may be appropriately set within a range that provides the desired effect of inhibiting a decrease in hardness, for example, 0.1 to 20% by weight, and from the viewpoint of more effectively inhibiting a decrease in tablet hardness, the content is preferably 0.5 to 15% by weight, more preferably 1 to 10% by weight, and even more preferably 1 to 6% by weight.

[0030] In the intra-oral instrument cleanser of the present disclosure, the content ratio of component (D) to component (C) is not particularly limited, and the content of component (D) per 1 part by weight of component (C) is, for example, 0.1 to 20 parts by weight. From the viewpoint of more effectively suppressing a decrease in tablet hardness, the content is preferably 0.5 to 15 parts by weight, more preferably 1 to 10 parts by weight, and even more preferably 1 to 6 parts by weight.

[0031] [Other ingredients] In addition to the components described above, the intra-oral instrument cleanser of the present disclosure may contain other components as necessary to the extent that the effects of the present disclosure are not impaired.

[0032] (Oxygen bleach) The intraoral instrument cleaner of the present disclosure preferably contains (E) an oxygen bleaching agent (hereinafter, sometimes referred to as component (E)). The oxygen bleaching agent is a bleaching agent that converts HO2 -By incorporating an oxygen bleaching agent together with cyclodextrin into the intraoral instrument cleanser, the intraoral instrument cleanser can be endowed with superior deodorizing power.

[0033] The oxygen bleaching agent is not particularly limited as long as it is non-toxic and physiologically acceptable, and can be widely used as a cleaning agent for an oral instrument. Examples of the oxygen bleaching agent include monopersulfate, perborate, percarbonate, and persulfate. The oxygen bleaching agents exemplified above may be used alone or in combination of two or more.

[0034] Specific examples of the monopersulfate include alkali metal salts of monopersulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. Specific examples of the perborate include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of the percarbonate include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of the persulfate include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. The oxygen bleaches exemplified above may be used alone or in combination of two or more. Of the oxygen bleaches exemplified above, from the viewpoint of imparting superior deodorizing power to the intraoral instrument cleanser, preferably at least one selected from the group consisting of monopersulfate and perborate, more preferably at least one selected from the group consisting of alkali metal monopersulfate and alkali metal perborate, and even more preferably at least one selected from the group consisting of potassium monopersulfate and sodium perborate.

[0035] In the intraoral instrument cleanser of the present disclosure, the content of component (E) may be appropriately set within a range in which the desired deodorizing power can be exhibited, for example, 1 to 40% by weight, and from the viewpoint of further enhancing the deodorizing power, the content is preferably 2 to 30% by weight, and more preferably 3 to 20% by weight.

[0036] (bleach activator) The intraoral instrument cleaner of the present disclosure preferably contains (F) a bleaching activator (hereinafter, sometimes referred to as component (F)). The bleaching activator is HO2 generated from an oxygen-based bleach in water. - It reacts with and produces organic peracids with a more effective bleaching effect.

[0037] The bleaching activator may be any known one without any particular limitation, and examples thereof include tetraacetylethylenediamine; alkanoyloxybenzenesulfonic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms; alkanoyloxybenzoic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms. Examples of the salt include alkali metal salts and ammonium salts. The bleaching activators exemplified above may be used alone or in combination of two or more. Among the bleaching activators exemplified above, tetraacetylethylenediamine is preferred from the viewpoint of excellent efficiency in generating an organic peracid.

[0038] In the intra-oral instrument cleanser of the present disclosure, the content of component (F) may be adjusted as appropriate according to the content of the oxygen bleach, and is, for example, 0.01 to 5% by weight. From the viewpoint of further enhancing the deodorizing power, the content is preferably 0.1 to 3% by weight, and more preferably 0.5 to 2% by weight.

[0039] (Surfactant) The intra-oral instrument cleanser of the present disclosure may contain a surfactant other than the α-olefin sulfonate. The surfactant plays a role as a component that exerts a chemical cleaning effect, etc.

[0040] The type of surfactant to be incorporated in the intraoral appliance cleaner of the present disclosure is not particularly limited as long as it is usable as a component of a cleaner, and any of anionic surfactants (other than α-olefin sulfonate), cationic surfactants, nonionic surfactants, and amphoteric surfactants may be used. Among these surfactants, anionic surfactants are preferable.

[0041] Examples of anionic surfactants include alkyl sulfates, alkylbenzenesulfonates, alkylsulfoacetates, and alkanesulfonates. Examples of salt forms of anionic surfactants include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochlorides. Among the above-listed anionic surfactants, alkyl sulfates are preferred, and sodium lauryl sulfate is more preferred.

[0042] In the intraoral instrument cleanser of the present disclosure, one type of surfactant may be blended alone, or two or more types of surfactants may be blended in combination.

[0043] In the intra-oral instrument cleanser of the present disclosure, the surfactant content (including the α-olefin sulfonate content) is not particularly limited as long as it is capable of exerting a foaming effect when cleaning intra-oral instruments, and may be set appropriately depending on the type of surfactant used, the cleaning power to be provided, etc., and can be, for example, 0.1 to 10 wt %, preferably 0.5 to 7 wt %, and more preferably 1 to 5 wt % in terms of the total amount of surfactant.

[0044] (Sugar alcohol) The oral appliance cleanser of the present disclosure may contain a sugar alcohol. The sugar alcohol is a component that acts as a binder.

[0045] The type of sugar alcohol is not particularly limited, and examples thereof include sorbitol, mannitol, xylitol, erythritol, etc. The sugar alcohols listed above may be used alone or in combination of two or more. Among the sugar alcohols listed above, sorbitol is preferred.

[0046] In the intraoral instrument cleanser of the present disclosure, the sugar alcohol content is, for example, 1 to 30 wt %, preferably 3 to 20 wt %, and more preferably 4 to 15 wt %, in terms of the total amount of sugar alcohol.

[0047] (Polyalkylene glycol) The intra-oral instrument cleanser of the present disclosure may contain a polyalkylene glycol. The polyalkylene glycol is a component that functions as a binder.

[0048] Specific examples of the polyalkylene glycol include polyethylene glycol, polypropylene glycol, and polybutylene glycol.

[0049] The polyalkylene glycol may be used alone or in combination of two or more. Among the polyalkylene glycols exemplified above, polyethylene glycol is preferable.

[0050] In the intra-oral instrument cleanser of the present disclosure, the content of polyalkylene glycol is, for example, 0.1 to 5 wt %, preferably 0.5 to 2 wt %, and more preferably 0.5 to 1.5 wt %.

[0051] (lubricant) The oral appliance cleanser of the present disclosure may contain a lubricant to facilitate the molding process into tablets.

[0052] The type of lubricant is not particularly limited, but examples thereof include magnesium stearate, calcium stearate, sodium stearyl fumarate, sucrose fatty acid esters, sodium lauryl sulfate, talc, light anhydrous silicic acid, and hydrated silicon dioxide.

[0053] The lubricant may be used alone or in combination of two or more. Among the lubricants exemplified above, magnesium stearate is preferred.

[0054] In the intraoral instrument cleanser of the present disclosure, the content of the lubricant is, for example, 0.01 to 2 wt %, preferably 0.02 to 1 wt %, and more preferably 0.02 to 0.5 wt %.

[0055] Other additives that can be incorporated into the intraoral instrument cleanser of the present disclosure include base materials (sodium sulfate, etc.), magnesium oxide, flavorings, colorants, deodorants, tartar inhibitors, rust inhibitors, chelating agents, pH adjusters, enzymes (proteases, etc.), sweeteners, cooling agents, foam stabilizers, preservatives, antibacterial agents, bactericides, preservatives, bulking agents, excipients, disintegrants, and fluidizing agents. The other components exemplified above may be incorporated alone or in any combination of two or more.

[0056] 2. Formulation and manufacturing method of oral instrument cleaner The intraoral instrument cleaner of the present disclosure is in tablet form. The tablet formulation can be carried out by a commonly used tableting method. For example, a raw material mixture obtained by mixing the components (A) to (D) and other additives that are blended as necessary may be subjected to a tableting process. In addition, the mixture may be granulated into granules as necessary prior to the tableting process. In addition, the tablet-shaped intraoral instrument cleaner of the present disclosure contains cyclodextrin, but further contains an α-olefin sulfonate, thereby suppressing a decrease in tablet hardness. Therefore, it is possible to effectively prevent the tablet from chipping or cracking due to a slight impact during transportation, etc.

[0057] In addition, in the tablet-shaped intraoral instrument cleanser of the present disclosure, the weight per tablet is not particularly limited and may be appropriately set based on ease of use, but it is desirable to set the weight per tablet to the amount required for one intraoral instrument cleansing. Specifically, the weight per tablet of the tablet-shaped intraoral instrument cleanser of the present disclosure is 1 to 4 g, preferably 2 to 3 g.

[0058] 3. Uses of oral instrument cleaners The intra-oral instrument cleanser of the present disclosure is used as a cleaner for various intra-oral instruments, but is particularly suitable for use as a denture cleanser.

[0059] 4. How to use the oral instrument cleaner When the tablet-shaped intraoral instrument cleaner of the present disclosure is put into water, heated if necessary, and an intraoral instrument (preferably a denture) to be cleaned is placed in the water, the tablet-shaped intraoral instrument cleaner of the present disclosure dissolves, and the intraoral instrument is cleaned by the foaming action caused by the reaction of the components (A) and (B). In addition, the intraoral instrument cleaner of the present disclosure exhibits excellent deodorizing power because it contains the component (C).

[0060] The water used when cleaning intraoral instruments using the tablet-form intraoral instrument cleanser of the present disclosure is not particularly limited, but examples thereof include tap water, purified water, distilled water, and physiological saline.

[0061] When cleaning an intra-oral instrument using the tablet-form intra-oral instrument cleanser of the present disclosure, the intra-oral instrument may be immersed in water and then the tablet-form intra-oral instrument cleanser of the present disclosure may be added, or the intra-oral instrument may be immersed in water after the tablet-form intra-oral instrument cleanser of the present disclosure has been added.

[0062] In addition, in cleaning intraoral instruments, the ratio of the tablet-type intraoral instrument cleaner of the present disclosure to water is appropriately set depending on the composition of the tablet-type intraoral instrument cleaner of the present disclosure, the degree of dirt on the intraoral instrument to be cleaned, etc., but for example, the tablet-type intraoral instrument cleaner may be usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight, per 100 parts by weight of water. More specifically, in one cleaning of an intraoral instrument, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g, more preferably 1 to 5 g of the tablet-type intraoral instrument cleaner of the present disclosure is added thereto.

[0063] The temperature during cleaning of intraoral instruments may be about room temperature. The time for immersing intraoral instruments in the cleaning solution is usually about 5 minutes to 24 hours, preferably about 10 minutes to 12 hours, and more preferably about 30 minutes to 8 hours.

[0064] In addition, while cleaning the intra-oral appliances, it is not necessary to stir the water to which the intra-oral appliance cleanser has been added. However, in order to more effectively remove dirt and the like from the intra-oral appliances, the water may be stirred as necessary, and the intra-oral appliances may be scrubbed with a cleaning tool such as a brush. EXAMPLES

[0065] The present invention will be described in more detail below with reference to examples, but the present disclosure is not limited to these examples.

[0066] Details of the following components used in the following test examples and formulation examples are as follows: Cyclodextrin: a mixture of 13 parts by weight of α-cyclodextrin, 20 parts by weight of β-cyclodextrin, 7 parts by weight of γ-cyclodextrin, and 60 parts by weight of powdered sugar Sodium α-olefin sulfonate: Contains an average of 14 to 16 carbon atoms per molecule Dextrin: Average degree of polymerization of 11

[0067] Test Example The components shown in Table 1 were thoroughly mixed in a vinyl bag, and the composition was compressed into tablets at a normal compression pressure of 6t using a 25φ die and a tableting machine (Riken Kikai, hydraulic pump, model number: SMP-3012SK) to prepare tablet-shaped intraoral instrument cleaners weighing 2.6 g per tablet. In Table 1, the amount in the cyclodextrin column indicates the total amount of α-, β-, and γ-cyclodextrin.

[0068] Each tablet-shaped intraoral instrument cleaner prepared was set in a hardness tester (Okada Seiko Co., Ltd., tablet hardness tester DC-50). The breaking terminal test speed was set to 0.5 mm / sec, and the load at which the load sensor (load cell) broke the tablet was recorded as hardness (kgf). This operation was performed for three tablets, and the average hardness was calculated. The results are shown in Table 1. If the tablet hardness is less than 4 kgf, the tablet will be chipped or cracked very frequently due to impact during transportation, etc., so the tablet hardness is preferably 4.0 kgf or more.

[0069] [Table 1]

[0070] As shown in Table 1, when sodium α-olefin sulfonate was added to the intraoral instrument cleaner containing cyclodextrin, the tablet hardness was 5.0 kgf or more, which was sufficient (Examples 1 to 3). On the other hand, when sodium α-olefin sulfonate was not added to the intraoral instrument cleaner containing cyclodextrin, the tablet hardness was less than 4.0 kgf, which was insufficient (Comparative Examples 1 and 2). In addition, when sodium lauryl sulfate was added to the intraoral instrument cleaner containing cyclodextrin instead of sodium α-olefin sulfonate, the tablet hardness was less than 4.0 kgf, which was insufficient (Comparative Example 3). In addition, the intraoral instrument cleaner not containing cyclodextrin had a tablet hardness of 5.0 kgf, which was sufficient (Reference Example 1). In addition, the oral instrument cleanser containing dextrin instead of cyclodextrin had a tablet hardness of 5.3 kgf, which was sufficient even without the incorporation of sodium α-olefin sulfonate (Reference Example 2). From the results shown in Table 1, it was confirmed that the decrease in tablet hardness could be effectively suppressed by incorporating sodium α-olefin sulfonate into the oral instrument cleanser containing cyclodextrin.

[0071] Prescription Examples Tablet-shaped intraoral instrument cleaners having the compositions shown in Table 2 were prepared in the same manner as in the above test examples, and the hardness of the tablets was measured. In Table 2, the amount of cyclodextrin in the column indicates the total amount of α-, β-, and γ-cyclodextrin. All of the intraoral instrument cleaners had a tablet hardness of 4.0 kgf or more, which was sufficient.

[0072] [Table 2]

Claims

1. A tablet-shaped intra-oral instrument cleanser comprising: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) a cyclodextrin; and (D) an α-olefin sulfonate.

2. The tablet-form intraoral instrument cleanser according to claim 1 , further comprising (E) an oxygen bleaching agent.

3. 3. The tablet-form intraoral instrument cleanser according to claim 2, wherein the oxygen bleaching agent is at least one selected from the group consisting of monopersulfate and perborate.

4. The tablet-form intraoral instrument cleanser according to claim 2 , further comprising (F) a bleaching activator.

5. 5. The tablet-form intraoral instrument cleanser according to claim 4, wherein the bleaching activator is tetraacetylethylenediamine.

6. 6. The tablet-form intraoral instrument cleanser according to claim 1, which is a denture cleanser.

7. A method for producing a tablet-form intraoral instrument cleanser, comprising subjecting a raw material mixture containing: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) a cyclodextrin; and (D) an α-olefin sulfonate to a tableting step.

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