Cleanser for oral appliances

Abstract

To provide a cleanser for oral appliances with excellent deodorizing performance using a novel formulation technology.SOLUTION: A cleanser for oral appliances disclosed herein comprises (A) cyclodextrin, and (B) at least one selected from the group consisting of alkyl sulfates with C8-20 alkyl groups, and hydrogen carbonates.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present disclosure relates to an oral instrument cleanser that has excellent deodorizing effects. [Background technology]

[0002] Dentures and other oral appliances are prone to bacteria, biofilms, and other deposits, and if left uncleaned, they can cause bad breath and may even contribute to oral diseases such as periodontal disease. Therefore, as part of oral care, it is essential to clean and keep oral appliances clean. Since bacteria and dirt adhering to oral appliances cannot be sufficiently removed by cleaning with a brush, cleaning with a detergent is important.

[0003] Cleaning of intraoral instruments with a detergent is generally performed by immersing the intraoral instruments in cleaning water prepared by adding the detergent to water. Conventionally, detergents for intraoral instruments have been formulated with surfactants and foaming agents (carbonic acid and acid), and are designed to enhance the cleaning effect by exerting chemical cleaning power due to surface activation and physical cleaning power due to foaming action when added to water.

[0004] In addition, in order to impart a bleaching effect and improve cleaning and deodorizing power, bleaching agents are generally blended in intraoral instrument cleaners. For example, Patent Document 1 proposes a denture cleaner containing an oxygen-based bleaching agent. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2005-272365 A Summary of the Invention [Problem to be solved by the invention]

[0006] However, formulation techniques that incorporate surfactants and foaming agents (carbonic acid and acid) or that incorporate bleaching agents into intraoral instrument cleansers have limitations in terms of improving the deodorizing power of intraoral instrument cleansers. In addition, from the perspective of expanding the variety of intraoral instrument cleansers, there has been a demand for the development of new formulation techniques to improve the deodorizing power of intraoral instrument cleansers.

[0007] The object of the present disclosure is to provide an oral instrument cleanser having excellent deodorizing effect through the use of new formulation technology. [Means for solving the problem]

[0008] The present inventors have conducted extensive research to solve the above problems, and have unexpectedly found that an intraoral instrument cleanser having excellent deodorizing effect can be obtained by blending at least one selected from the group consisting of alkyl sulfates having an alkyl group with 8 to 20 carbon atoms and hydrogen carbonates together with cyclodextrin. The present disclosure has been completed based on such findings and through further research.

[0009] That is, the present disclosure provides the inventions of the following aspects. Item 1. An intra-oral instrument cleanser comprising: (A) a cyclodextrin; and (B) at least one member selected from the group consisting of alkyl sulfates having an alkyl group having 8 to 20 carbon atoms and hydrogen carbonates. Item 2. The oral instrument cleanser according to Item 1, wherein the alkyl sulfate is lauryl sulfate. Item 3. The oral instrument cleanser according to Item 1, wherein the bicarbonate is sodium bicarbonate. Item 4. The intraoral instrument cleanser according to any one of Items 1 to 3, which is a denture cleanser. Item 5. Use of a composition comprising (A) a cyclodextrin and (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group having 8 to 20 carbon atoms and hydrogen carbonates, for cleaning an intraoral appliance. Item 6. Use of a composition comprising (A) cyclodextrin and (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group having 8 to 20 carbon atoms and hydrogen carbonates as an intraoral instrument cleanser. Item 7. A method for cleaning an intraoral instrument, comprising immersing an intraoral instrument in water containing an intraoral instrument cleanser that contains (A) cyclodextrin and (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group having 8 to 20 carbon atoms and hydrogen carbonates. Effect of the Invention

[0010] The intraoral instrument cleaner of the present disclosure exhibits an excellent deodorizing effect by containing a combination of cyclodextrin and at least one selected from the group consisting of alkyl sulfates having an alkyl group with 8 to 20 carbon atoms and hydrogen carbonates. In addition, the intraoral instrument cleaner of the present disclosure has an excellent deodorizing effect due to the adoption of a new formulation technology in which cyclodextrin is combined with at least one selected from the group consisting of alkyl sulfates having an alkyl group with 8 to 20 carbon atoms and hydrogen carbonates, and has the advantage of being able to expand the variety of intraoral instrument cleaners having a deodorizing effect. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] In this specification, the notation X to Y regarding a numerical range means that the range is from X to Y.

[0012] In this specification, the term "oral appliance" refers to a dental appliance that needs to be worn and removed in the oral cavity, such as a complete denture, a partial denture, an orthodontic appliance, a retainer, and a mouthpiece.

[0013] 1. Mouth instrument cleaner The intraoral instrument cleaner of the present disclosure is characterized by containing (A) cyclodextrin (hereinafter, may be referred to as component (A)) and (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group with 8 to 20 carbon atoms and hydrogen carbonates (hereinafter, may be referred to as component (B)). The intraoral instrument cleaner of the present disclosure will be described in detail below.

[0014] [Cyclodextrin] The intraoral instrument cleanser of the present disclosure contains cyclodextrin as component (A). In the intraoral instrument cleanser of the present disclosure, cyclodextrin is a component that is blended in combination with component (B) to impart excellent deodorizing power to the intraoral instrument cleanser.

[0015] The cyclodextrin is not particularly limited, and examples thereof include those having 5 or more glucose atoms bound thereto, specifically, α-cyclodextrin having 6 glucose atoms bound thereto, β-cyclodextrin having 7 glucose atoms bound thereto, and γ-cyclodextrin having 8 glucose atoms bound thereto, etc. The cyclodextrins exemplified above may be used alone or in combination of two or more kinds.

[0016] In one embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use α-, β-, or γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. In another embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use any two kinds selected from the group consisting of α-, β-, and γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. In another embodiment of the intraoral instrument cleaner of the present disclosure, it is preferable to use three kinds of α-, β-, and γ-cyclodextrin as the cyclodextrin from the viewpoint of further improving the deodorizing power. When α-, β-, and γ-cyclodextrin are used, the weight ratios of α-, β-, and γ-cyclodextrin are not particularly limited, but from the viewpoint of further improving the deodorizing power, when the total amount of α-, β-, and γ-cyclodextrin is taken as 100 parts by weight, the content of α-cyclodextrin is preferably 20 to 40 parts by weight, and more preferably 25 to 35 parts by weight, the content of β-cyclodextrin is preferably 35 to 70 parts by weight, and more preferably 45 to 60 parts by weight, and the content of γ-cyclodextrin is preferably 10 to 25 parts by weight, and more preferably 15 to 20 parts by weight.

[0017] In the intra-oral instrument cleanser of the present disclosure, the content of component (A) may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.01 to 20% by weight, and from the viewpoint of further improving the deodorizing power, the content is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight, and even more preferably 0.5 to 3% by weight.

[0018] [Alkyl sulfates and hydrogen carbonates having alkyl groups with 8 to 20 carbon atoms] The intraoral instrument cleanser of the present disclosure contains, as component (B), at least one selected from the group consisting of alkyl sulfates having an alkyl group with 8 to 20 carbon atoms and hydrogen carbonates. Component (B) is a component that can significantly improve the deodorizing power of the intraoral instrument cleanser by being contained in combination with cyclodextrin. The alkyl sulfate also serves as an anionic surfactant and as a component that exerts a chemical cleaning action. In addition, when the intraoral instrument cleanser contains an acid described below, the hydrogen carbonate serves as a constituent component of a foaming agent and plays a role of reacting with the acid to generate carbon dioxide gas during cleaning of the intraoral instrument.

[0019] The number of carbon atoms of the alkyl group constituting the alkyl sulfate is required to be 8 to 20, preferably 10 to 18, and more preferably 12 to 18, from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser. The alkyl group constituting the alkyl sulfate may be either linear or branched, but is preferably linear. Examples of salts constituting the alkyl sulfate include alkali metal salts such as sodium salts and potassium salts. The alkyl sulfate may be used alone or in combination of two or more.

[0020] Among the alkyl sulfates, from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, preferred is lauryl sulfate, more preferred is alkali metal lauryl sulfate, and even more preferred is sodium lauryl sulfate.

[0021] In the intraoral instrument cleanser of the present disclosure, the content of the alkyl sulfate may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.01 to 20% by weight, and from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight, and even more preferably 0.5 to 3% by weight.

[0022] In the intraoral instrument cleanser of the present disclosure, the content ratio of the alkyl sulfate relative to component (A) is not particularly limited, and the content of the alkyl sulfate per 1 part by weight of component (A) is, for example, 0.1 to 15 parts by weight. From the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.3 to 10 parts by weight, more preferably 0.5 to 8 parts by weight, and even more preferably 1 to 5 parts by weight.

[0023] The hydrogen carbonate salt is not particularly limited, but examples thereof include alkali metal hydrogen carbonate salts such as sodium hydrogen carbonate and potassium hydrogen carbonate, and preferably sodium hydrogen carbonate. The hydrogen carbonate salts may be used alone or in combination of two or more.

[0024] In the intraoral instrument cleanser of the present disclosure, the content of bicarbonate may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.1 to 30% by weight, and from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.5 to 20% by weight, more preferably 1 to 18% by weight, and even more preferably 3 to 15% by weight.

[0025] In the intraoral instrument cleanser of the present disclosure, the content ratio of bicarbonate relative to component (A) is not particularly limited, and the content of bicarbonate per 1 part by weight of component (A) is, for example, 0.1 to 50 parts by weight. From the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.5 to 45 parts by weight, more preferably 1 to 40 parts by weight, and even more preferably 3 to 30 parts by weight.

[0026] [Other ingredients] In addition to the components described above, the intra-oral instrument cleanser of the present disclosure may contain other components as necessary to the extent that the effects of the present disclosure are not impaired.

[0027] (foaming agent) The intra-oral instrument cleaner of the present disclosure may contain a foaming agent. When the intra-oral instrument cleaner of the present disclosure contains a foaming agent, carbon dioxide bubbles can be generated in the cleaning water, and physical cleaning power can be exerted by the foaming action.

[0028] There are no particular limitations on the type of foaming agent, so long as it is non-toxic and physiologically acceptable, and a wide range of foaming agents commonly used in intraoral instrument cleaners (i.e., those capable of generating carbon dioxide in water) can be used.

[0029] Examples of the foaming agent include a combination of at least one of carbonates and a double salt of hydrogencarbonate and carbonate (hereinafter, sometimes referred to as a carbonate compound) and an acid. Examples of carbonates include, but are not limited to, alkali metal salts of carbonic acid such as sodium carbonate and potassium carbonate. Examples of double salts of carbonate and hydrogencarbonate include, but are not limited to, sodium sesquicarbonate. The carbonate compounds may be used alone or in combination of two or more. Examples of acids include, but are not limited to, organic acids such as citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, and the like; inorganic acids such as phosphoric acid and sulfamic acid, and the like. The acids may be used alone or in combination of two or more.

[0030] The carbonate compound constituting the foaming agent is preferably an alkali metal salt of carbonate, more preferably sodium carbonate, and the acid constituting the foaming agent is preferably an organic acid, more preferably citric acid and malic acid.

[0031] In the foaming agent, the ratio of the carbonate compound to the acid is not particularly limited as long as the two can react in water to generate carbon dioxide. The content of the acid per 100 parts by weight of the carbonate compound is, for example, 10 to 200 parts by weight, preferably 15 to 150 parts by weight, and more preferably 20 to 100 parts by weight.

[0032] When the intra-oral instrument cleansing agent of the present disclosure contains a foaming agent, the content of the foaming agent (total amount of carbonate compound and acid) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intra-oral instruments, and can be, for example, 10 to 75% by weight, preferably 20 to 70% by weight, and more preferably 30 to 65% by weight.

[0033] (Bleach) The intra-oral instrument cleanser of the present disclosure may contain a bleaching agent. By including a bleaching agent, cleaning power can be improved.

[0034] The type of bleach used in the intraoral instrument cleanser of the present disclosure is not particularly limited as long as it is non-toxic and physiologically acceptable, and any bleach commonly used in intraoral instrument cleansers can be used.

[0035] Bleaching agents include, for example, oxygen-based bleaching agents such as monopersulfates, perborates, percarbonates, and persulfates.

[0036] Specific examples of the monopersulfate include alkali metal salts of monopersulfate such as sodium monopersulfate and potassium monopersulfate (bis(peroxymonosulfate)·bis(sulfate)·pentapotassium, etc.), ammonium monopersulfate, and hydrates thereof. Specific examples of the perborate include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of the percarbonate include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of the persulfate include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. The bleaching agents exemplified above may be used alone or in combination of two or more. Among the bleaching agents exemplified above, preferred are hydrogen monopersulfates, perborates, and percarbonates, more preferred are alkali metal salts of hydrogen monopersulfates, alkali metal salts of perboric acid, and alkali metal salts of percarbonate, and even more preferred are potassium hydrogen monopersulfate, sodium perborate, and sodium percarbonate.

[0037] In the intra-oral instrument cleanser of the present disclosure, the content of the bleaching agent may be appropriately set within a range that can exert the desired bleaching effect, and may be, for example, 1 to 40% by weight, preferably 5 to 35% by weight, and more preferably 10 to 30% by weight.

[0038] (bleach activator) When the intraoral instrument cleaner of the present disclosure contains an oxygen bleaching agent, it may contain a bleaching activator. The bleaching activator is HO generated from the oxygen bleaching agent in water. 2 - It reacts with and produces organic peracids with a more effective bleaching effect.

[0039] The bleaching activator may be any known one without any particular limitation, and examples thereof include tetraacetylethylenediamine; alkanoyloxybenzenesulfonic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms; alkanoyloxybenzoic acid or its salt having an alkanoyl group having 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms. Examples of the salt include alkali metal salts and ammonium salts. The bleaching activators exemplified above may be used alone or in combination of two or more. Among the bleaching activators exemplified above, tetraacetylethylenediamine is preferred from the viewpoint of excellent efficiency in generating an organic peracid.

[0040] In the intra-oral instrument cleanser of the present disclosure, the content of the bleach activator may be appropriately adjusted according to the content of the oxygen bleach, and may be, for example, 0.01 to 5 wt %, preferably 0.1 to 3 wt %, and more preferably 0.5 to 2 wt %.

[0041] (Surfactant) The intra-oral instrument cleanser of the present disclosure may contain a surfactant other than the alkyl sulfate. The surfactant plays a role as a component that exerts a chemical cleansing effect.

[0042] The type of surfactant to be incorporated in the intra-oral appliance cleaner of the present disclosure is not particularly limited as long as it is usable as a component of a cleaner, and any of anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants may be used. Among these surfactants, anionic surfactants are preferable.

[0043] Examples of anionic surfactants include α-olefin sulfonate, alkylbenzene sulfonate, alkylsulfoacetate, alkane sulfonate, etc. Examples of salt forms of anionic surfactants include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochloride.

[0044] In the intraoral instrument cleanser of the present disclosure, one type of surfactant may be blended alone, or two or more types of surfactants may be blended in combination.

[0045] In the intra-oral instrument cleanser of the present disclosure, the surfactant content (including the alkyl sulfate content) is not particularly limited as long as it is capable of exerting a foaming effect when cleaning intra-oral instruments, and may be set appropriately depending on the type of surfactant used, the cleaning power to be provided, etc., and may be, for example, 0.1 to 10 wt %, preferably 0.5 to 7 wt %, and more preferably 1 to 5 wt % in terms of the total amount of surfactant.

[0046] (Sugar alcohol) The oral appliance cleanser of the present disclosure may contain a sugar alcohol. The sugar alcohol is a component that acts as a binder.

[0047] The type of sugar alcohol is not particularly limited, and examples thereof include sorbitol, mannitol, xylitol, erythritol, etc. The sugar alcohols listed above may be used alone or in combination of two or more. Among the sugar alcohols listed above, sorbitol is preferred.

[0048] In the intraoral instrument cleanser of the present disclosure, the sugar alcohol content is, for example, 1 to 30 wt %, preferably 3 to 20 wt %, and more preferably 4 to 15 wt %, in terms of the total amount of sugar alcohol.

[0049] (Polyalkylene glycol) The intra-oral instrument cleanser of the present disclosure may contain a polyalkylene glycol. The polyalkylene glycol is a component that functions as a binder.

[0050] Specific examples of the polyalkylene glycol include polyethylene glycol, polypropylene glycol, and polybutylene glycol.

[0051] The polyalkylene glycol may be used alone or in combination of two or more. Among the polyalkylene glycols exemplified above, polyethylene glycol is preferable.

[0052] In the intra-oral instrument cleanser of the present disclosure, the content of polyalkylene glycol is, for example, 0.1 to 5 wt %, preferably 0.5 to 2 wt %, and more preferably 0.5 to 1.5 wt %.

[0053] (lubricant) The oral appliance cleanser of the present disclosure may contain a lubricant to facilitate the molding process into tablets.

[0054] The type of lubricant is not particularly limited, but examples thereof include magnesium stearate, calcium stearate, sodium stearyl fumarate, sucrose fatty acid esters, sodium lauryl sulfate, talc, light anhydrous silicic acid, and hydrated silicon dioxide.

[0055] The lubricant may be used alone or in combination of two or more. Among the lubricants exemplified above, magnesium stearate is preferred.

[0056] In the intra-oral instrument cleanser of the present disclosure, the content of the lubricant is, for example, 0.01 to 1 wt %, preferably 0.015 to 0.5 wt %, and more preferably 0.02 to 0.3 wt %.

[0057] Other additives that can be incorporated into the intraoral instrument cleanser of the present disclosure include base materials (sodium sulfate, etc.), magnesium oxide, flavorings, colorants, deodorants, tartar inhibitors, rust inhibitors, chelating agents, pH adjusters, enzymes (proteases, etc.), sweeteners, cooling agents, foam stabilizers, preservatives, antibacterial agents, bactericides, preservatives, bulking agents, excipients, disintegrants, and fluidizing agents. The other components exemplified above may be incorporated alone or in any combination of two or more.

[0058] 2. Formulation of oral instrument cleanser The intraoral instrument cleaner of the present disclosure is solid, specifically, molded into a powder, granule, or tablet, preferably molded into a granule or tablet, and most preferably molded into a tablet. When molded into a tablet, the weight of each tablet is not particularly limited and may be appropriately set based on ease of use, but it is desirable to set the weight of each tablet to the amount required for one intraoral instrument cleaner. Specifically, the weight of each tablet is 1 to 4 g, preferably 2 to 3 g.

[0059] The tablet-shaped intraoral instrument cleanser may be produced according to a known method, for example, by subjecting a mixture of component (A) and component (B) and other components added as necessary to a granule forming process such as granulation or a tablet forming process such as tableting to produce the intraoral instrument cleanser of the present disclosure.

[0060] 3. Uses of oral instrument cleaners The intra-oral instrument cleanser of the present disclosure is used as a cleaner for various intra-oral instruments, but is particularly suitable for use as a denture cleanser.

[0061] 4. How to use the oral instrument cleaner When the intraoral instrument cleaner of the present disclosure is put into water, heated if necessary, and the intraoral instrument (preferably a denture) to be cleaned is placed in the water, the intraoral instrument cleaner of the present disclosure dissolves and cleans the intraoral instrument. In addition, since the intraoral instrument cleaner of the present disclosure contains components (A) and (B), the odor of the intraoral instrument after cleaning can be effectively reduced by immersing the intraoral instrument in the cleaning solution.

[0062] The water used when cleaning intra-oral instruments with the intra-oral instrument cleanser of the present disclosure is not particularly limited, but examples thereof include tap water, purified water, distilled water, and physiological saline water.

[0063] When cleaning an intraoral appliance using the intraoral appliance cleanser of the present disclosure, the intraoral appliance may be immersed in water and then the intraoral appliance cleanser of the present disclosure may be added, or the intraoral appliance may be immersed in water and then the intraoral appliance may be added.

[0064] In addition, in cleaning intraoral instruments, the ratio of the intraoral instrument cleaner of the present disclosure to water is appropriately set depending on the composition of the intraoral instrument cleaner of the present disclosure, the degree of dirt on the intraoral instrument to be cleaned, etc., but for example, the intraoral instrument cleaner may be usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight, per 100 parts by weight of water. More specifically, in one cleaning of intraoral instruments, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g, more preferably 1 to 5 g of the intraoral instrument cleaner of the present disclosure is added to this.

[0065] The temperature during cleaning of intraoral instruments may be about room temperature. The time for immersing intraoral instruments in the cleaning solution is usually about 5 minutes to 24 hours, preferably about 10 minutes to 12 hours, and more preferably about 30 minutes to 8 hours.

[0066] In addition, while cleaning the intra-oral appliances, it is not necessary to stir the water to which the intra-oral appliance cleanser has been added. However, in order to more effectively remove dirt, odors, and the like from the intra-oral appliances, the water may be stirred as necessary, and the intra-oral appliances may be scrubbed with a cleaning tool such as a brush. EXAMPLES

[0067] The present invention will be described in more detail below with reference to examples, but the present disclosure is not limited to these examples.

[0068] Details of the cyclodextrins used in the following test examples and formulation examples are as follows: Cyclodextrin: a mixture of 13 parts by weight of α-cyclodextrin, 20 parts by weight of β-cyclodextrin, 7 parts by weight of γ-cyclodextrin, and 60 parts by weight of powdered sugar Sodium α-olefin sulfonate: Contains an average of 14 to 16 carbon atoms per molecule

[0069] Test Example A tablet-shaped intraoral instrument cleaner was prepared with the composition shown in Table 1. Specifically, the composition obtained by mixing the components shown in Table 1 was tableted at 40 MPa using a 22φ diameter die and a tableting machine (SMP-3012SK, small electric hydraulic pump, manufactured by Rikenki Co., Ltd.) to prepare tablet-shaped intraoral instrument cleaners weighing 2 g each. In Table 1, the amount in the cyclodextrin column indicates the total amount of α-, β-, and γ-cyclodextrin.

[0070] The prepared intraoral instrument cleansers were subjected to a deodorizing test in the following manner.

[0071] <Deodorization test A> 200μl of a malodorous aqueous solution containing methyl mercaptan (methyl mercaptan concentration: 3000ppm) was placed in a glass container. Also, one tablet of each of the intraoral instrument cleaners prepared in Examples 1-6 and Comparative Examples 1-7 was put into 180ml of water at 25°C to prepare a cleaning solution. Then, 400μl of each of the prepared cleaning solutions was added to the glass container, and the mouth of the glass container was sealed with paraffin film. Then, the glass container was left to stand at 25°C for 30 minutes. Thereafter, the concentration (ppm) of methyl mercaptan contained in the gas in the glass container was measured using a detector tube gas measuring instrument and a detector tube 71H·71 (manufactured by Gastec Corporation). The results are shown in Table 1. It is considered that the lower the concentration of methyl mercaptan contained in the gas in the glass container, the higher the ability of the components contained in the intraoral instrument cleaner to retain (encapsulate) methyl mercaptan.

[0072] <Deodorization test B> A resin chip (20mm x 20mm x 1.5mm) of a denture material was immersed in the malodorous aqueous solution used in deodorization test A. The resin chip removed from the malodorous aqueous solution was immersed in a glass container containing 180ml of water at 25°C, and one tablet of each of the intraoral instrument cleaners prepared in Examples 1 to 6 and Comparative Examples 1 to 7 was added and dissolved. The resin chip was then left to stand at 25°C for 3 hours to clean the resin chip. After cleaning, the resin chip was removed and placed in a 10L airbag, which was filled with 1.5L of odorless air per 5 resin chips. After leaving to stand at 25°C for 10 minutes, the gas in the airbag was subjected to a sensory evaluation of the deodorizing properties. A 6-stage odor intensity method was adopted for the sensory evaluation of the deodorizing properties.

[0073] [6-level odor intensity method] The odor intensity of the gas inside the airbag was scored using a six-point odor intensity method (0: no odor, 1: barely detectable odor, 2: weak odor that is identifiable, 3: easily detectable odor, 4: strong odor, 5: awful odor). The odor intensity was scored by eight trained sensory evaluation monitors who had passed an olfactory blindness test, and the average of the scores from the six monitors was used, excluding one monitor who scored the highest and one who scored the lowest. The results are shown in Table 1. The lower the average odor intensity, the better the deodorizing effect of the intraoral instrument cleaner.

[0074] [Table 1]

[0075] As shown in Table 1, the intraoral instrument cleansers containing both cyclodextrin and sodium lauryl sulfate (Examples 1 to 3) and the intraoral instrument cleansers containing both cyclodextrin and sodium bicarbonate (Examples 4 to 6) had a very low methyl mercaptan concentration and a low average odor intensity compared to the intraoral instrument cleansers not containing either cyclodextrin or sodium lauryl sulfate or sodium bicarbonate (Comparative Examples 1 to 7), demonstrating very excellent deodorizing effects.

[0076] Prescription Examples Tablet-shaped intraoral instrument cleaners having the compositions shown in Tables 2 and 3 were prepared in the same manner as in the above-mentioned Test Example, and deodorization tests were carried out in the same manner as in the above-mentioned Test Example. In Tables 2 and 3, the amount in the cyclodextrin column indicates the total amount of α-, β-, and γ-cyclodextrin. As a result of the deodorization tests, it was confirmed that all of the intraoral instrument cleaners had an excellent deodorizing effect.

[0077] [Table 2]

[0078] [Table 3]

Claims

1. An intra-oral instrument cleanser comprising: (A) a cyclodextrin; and (B) at least one member selected from the group consisting of alkyl sulfates having an alkyl group having 8 to 20 carbon atoms, and hydrogen carbonates.

2. The oral instrument cleanser according to claim 1 , wherein the alkyl sulfate is lauryl sulfate.

3. The oral instrument cleaner of claim 1 , wherein the bicarbonate is sodium bicarbonate.

4. The intraoral instrument cleanser according to any one of claims 1 to 3, which is a denture cleanser.

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