Composition for improving skin compatibility

Abstract

To provide a novel composition for improving skin compatibility.SOLUTION: The present invention provides a composition for improving skin compatibility, comprising honey, wherein the contact angle of water on skin after application of the composition is 30 degrees or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for improving skin compatibility. [Background technology]

[0002] Since the stratum corneum of the skin acts as a barrier against water evaporation from within the body and against the intrusion of viruses, substances, etc. from the outside, it is difficult to deliver a sufficient amount of a compound, such as a medicine or a cosmetic, from outside the skin into the skin. On the other hand, cosmetics (also called booster serums or introduction liquids (introduction serums), etc.) that aim to promote the penetration of ingredients in a formulation to be applied next into the skin are also available on the market, and such cosmetics contain, for example, surfactants, polyols, lactic acid, etc.

[0003] For example, Patent Document 1 discloses a skin care pretreatment method, as a method for improving the compatibility and penetration of a subsequent skin care cosmetic, which comprises the steps of: (1) washing the skin with a skin cleanser, and then rinsing the cleanser with water; (2) shaking and applying to the skin while the skin is still wet a skin rinse composition having an oil phase that is liquid at room temperature and an aqueous phase in which the oil phase and the aqueous phase are separated into two layers, the oil phase accounting for 3 to 30% by mass of the composition and containing 1% by mass or more of a higher fatty acid that is liquid at room temperature; and (3) rinsing the skin rinse composition with water.

[0004] In addition, in relation to compositions to be applied to the skin, for example, Patent Document 2 discloses a fermented product obtained by fermenting honey and chamomile or a processed product thereof with Lactobacillus kunkeii, and describes that the fermented product can be used to improve skin barrier function, moisturize skin, improve skin elasticity, improve skin dullness, improve skin wrinkles, improve skin roughness, prevent skin aging, improve skin texture, and improve sensitive skin. Furthermore, Non-Patent Document 1 describes that a cream containing bioengineered medicinal honey, which has been proven to kill multidrug-resistant strains of bacteria by delivering reactive oxygen species, shows a low contact angle on pig skin while maintaining its bactericidal action, and the cream spreads well on the skin surface. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent No. 5022583 [Patent Document 2] Patent No. 6888835 [Non-patent literature]

[0006] [Non-Patent Document 1] O'Farrell C, et al., “Formulationof an antibacterial topical cream containing bioengineered honey that generatesreactive oxygen species.” Biomater Adv. 2022 Feb;133:112664. doi:10.1016 / j.msec.2022.112664. Epub 2022 Jan 20. Summary of the Invention [Problem to be solved by the invention]

[0007] An object of the present invention is to provide a novel composition for improving skin compatibility. [Means for solving the problem]

[0008] As a result of intensive research conducted by the inventors to achieve the above-mentioned object, they discovered that after honey is applied to an artificial skin model, the contact angle of water with the artificial skin model to which honey has been applied is 30 degrees or less, which led to the completion of the present invention.

[0009] That is, the present invention relates to, for example, the following inventions. [1] A composition for improving skin compatibility, comprising honey, wherein the contact angle of water with the skin to which the composition is applied is 30 degrees or less. [2] The composition described in [1], further containing royal jelly, butylene glycol and pentylene glycol. [3] The composition described in [1] or [2], further containing a lactobacillus fermentation extract of honey. [4] The composition described in [3], wherein the honey fermentation extract is obtained by fermenting honey and chamomile flowers using Lactobacillus kunkii. [5] The composition according to any one of [1] to [4], wherein the honey is manuka honey and / or acacia honey. Effect of the Invention

[0010] According to the present invention, a novel composition for improving skin compatibility can be provided. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] Hereinafter, an embodiment of the present invention will be described in detail. However, the present invention is not limited to the following embodiment.

[0012] [Composition] The composition for improving skin compatibility according to this embodiment (hereinafter also referred to as "composition") contains honey, and the contact angle of water with the skin to which the composition is applied is 30 degrees or less.

[0013] The composition according to the present embodiment has a contact angle of water on the skin to which the composition is applied of 30 degrees or less, and has the effect of improving skin compatibility. Here, in this specification, "improving skin compatibility" means improving the compatibility of hydrophobic or hydrophilic liquid with the skin, and can be evaluated by whether the contact angle of water on the skin when water is dropped on the skin to which the composition is applied is smaller than the contact angle of the skin to which the composition is not applied. If the contact angle of water is smaller before and after application of the composition, it can be determined that the skin compatibility has been improved. In addition, the contact angle of water is generally used as an index for wettability evaluation. Therefore, the composition according to the present embodiment can also be rephrased as a composition for improving the wettability of the skin.

[0014] In the measurement of the contact angle of water, the skin to which the composition according to the present embodiment is applied may be natural skin or artificial skin. The natural skin may be the skin of a human or other animal, and is preferably human skin. In the case of human skin, it may be the skin of the cheek, forearm, etc., and is preferably hairless (hair removed). In the case of artificial skin, it may be, for example, a skin that imitates human skin, and may be an artificial skin differentiated by iPS cells or an artificial skin model made of urethane. When determining whether the contact angle of water on the skin to which the composition is applied is 30 degrees or less, the skin is the skin of the forearm or an artificial skin model made of urethane, 0.1 g of the composition is uniformly applied within 5 cm x 5 cm on the skin, and 2 μl of water is dropped one hour later, and the contact angle is measured immediately (1000 milliseconds later) after dropping water (pure water such as distilled water).

[0015] The contact angle of water can be measured using, for example, an automatic contact angle meter DMo-602 (manufactured by Kyowa Interface Science Co., Ltd.). The contact angle of water can be measured, for example, by a sessile drop method. The contact angle of water can be analyzed (calculated), for example, by the θ / 2 method, the tangent method, or the like.

[0016] Although it varies depending on the part, human skin has a contact angle of about 60 degrees to 102 degrees. In addition, the contact angle of water on the human forearm is generally about 90 degrees, and artificial skin also has a contact angle of water close to that of the human forearm. It is preferable to use skin of animals other than humans with a contact angle of water of about 90 degrees. It is preferable that the composition according to the present embodiment has a contact angle of water with the skin when water is dropped onto the skin to which the composition is applied, which is smaller by 50 degrees or more, 55 degrees or more, 60 degrees or more, or 65 degrees or more than the contact angle of water with the skin to which the composition is not applied.

[0017] The composition of this embodiment may have a water contact angle with the skin to which the composition is applied of 30 degrees or less, and may be, for example, 28 degrees or less, 26 degrees or less, 24 degrees or less, 22 degrees or less, 20 degrees or less, 18 degrees or less, 16 degrees or less, 14 degrees or less, or 13 degrees or less, or may be 0 degrees or more, 1 degree or more, 3 degrees or more, or 5 degrees or more.

[0018] The composition according to the present embodiment is applied to the skin, and can be applied to any part of the skin. In this specification, "applying" may mean spreading or spraying.

[0019] Honey is produced by bees using nectar collected from plant flowers, tree sap, and the secretions of insects that parasitize plants as the main ingredient.

[0020] The type of honey contained in the composition according to the present embodiment is not particularly limited, and examples that can be used include honeydew honey, urumo honey, manuka honey, acacia honey, linden honey, rewarewa honey, flower honey, clover honey, orange honey, astragalus honey, rosemary honey, sunflower honey, rapeseed honey, coffee honey, linden honey, coriander (coriander) honey, horse chestnut honey, buckwheat honey, horse mackerel honey, soyogo honey, black nemochi honey, and karasusansho honey. The honey is preferably manuka honey and / or acacia honey.

[0021] Manuka honey is honey collected from the flowers of the manuka (Leptospermum scoparium) plant, which belongs to the Myrtaceae family. Acacia honey is honey collected from the flowers of the Robinia pseudoacacia plant, which belongs to the Leguminosae family.

[0022] The type of bee used to collect honey is not particularly limited. Honey can be obtained, for example, as a beekeeping product in a conventional manner.

[0023] While honey is stored in a beehive, it is generally kept at around 35°C by the body temperature of the bees. Honey collected from the beehive is generally heated as needed to reduce the viscosity to facilitate transportation, packing, and other operations, and to melt crystals.

[0024] After harvesting, the honey may be left as it is, or may be subjected to processes such as removal of proteins, wax, debris, beehive residues, filtration, extraction with organic solvents, purification processes such as fractionation, sterilization, concentration, etc., before or after heating.

[0025] Honey has been known to have moisturizing properties, but it has not been known to have the effect of improving skin compatibility.

[0026] The honey content in the composition according to this embodiment may be, for example, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, or 30% by mass or more, relative to the total amount of the composition, and may be 100% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, or 60% by mass or less.

[0027] The composition according to the present embodiment may further contain royal jelly, butylene glycol, and pentylene glycol, which reduces the contact angle of water with the skin to which the composition according to the present embodiment is applied, thereby improving skin compatibility.

[0028] The royal jelly in the present invention includes fresh royal jelly, dried royal jelly, dried royal jelly powder, enzyme-treated royal jelly, royal jelly extract, royal jelly fermentation product, etc. Furthermore, royal jelly may be produced in any of European countries, Oceanian countries, America, Brazil, Japan, China, other Asian countries, etc.

[0029] Dried royal jelly powder is obtained by drying fresh royal jelly to powder. As a drying method, any known method adopted in general food processing can be used, such as natural drying such as ventilation drying or sun drying, forced drying by heating with electricity or the like, freeze drying, etc. Freeze drying is preferred.

[0030] The enzyme-treated royal jelly is royal jelly treated with a proteolytic enzyme (protease). Preferably, the enzyme-treated royal jelly is hypoallergenic, in which allergic reactions caused by proteins contained in royal jelly are suppressed by protease treatment. Therefore, the enzyme-treated royal jelly may contain organic acids such as the above-mentioned saturated fatty acids and unsaturated fatty acids, lipids, sugars, vitamins, and various minerals, in addition to the protease decomposition products of proteins contained in royal jelly.

[0031] The royal jelly used to produce the enzyme-treated royal jelly is not particularly limited, and examples thereof include raw royal jelly, royal jelly powder obtained by drying and powdering raw royal jelly, and raw royal jelly extracted with water or aqueous ethanol, etc.

[0032] Enzyme-treated royal jelly can be produced by treating royal jelly raw material with an enzyme having at least endopeptidase activity, an enzyme having at least exopeptidase activity, and / or an enzyme having both endopeptidase activity and exopeptidase activity.

[0033] Examples of proteolytic enzymes having at least endopeptidase activity include endopeptidases derived from animals (e.g., trypsin, chymotrypsin, etc.), plants (e.g., papain, etc.), and microorganisms (e.g., lactic acid bacteria, yeast, mold, Bacillus subtilis, actinomycetes, etc.).

[0034] Examples of proteolytic enzymes having at least exopeptidase activity include carboxypeptidase, aminopeptidase, exopeptidases derived from microorganisms (e.g., lactic acid bacteria, Aspergillus bacteria, Rhizopus bacteria, etc.), and pancreatin and pepsin which also have endopeptidase activity.

[0035] Among these various enzymes, preferred examples of enzymes having both exopeptidase activity and endopeptidase activity include peptidase produced by Streptomyces griseus (trade name: Actinase AS), peptidase produced by Aspergillus oryzae (trade name: Protease A, Flavorzyme, Proteax), and peptidase produced by Aspergillus melleus (trade name: Protease P). Preferred examples of enzymes having exoprotease activity include peptidase produced by Aspergillus oryzae (trade name: Umamizyme G, Promod 192P, Promod 194P, Sumizyme FLAP), peptidase produced by Aspergillus sojae (trade name: Sternzyme B15024), peptidase produced by the genus Aspergillus (trade name: Coclase P), and peptidase produced by Rhizopus oryzae (trade name: Peptidase R). Further preferred examples of enzymes having endoprotease activity include peptidase produced by Bacillus subtilis (trade name: Orientase 22BF, Nucleisin), peptidase produced by Bacillus licheniformis (trade name: Alcalase), peptidase produced by Bacillus stearothermophilus (trade name: Protease S), peptidase produced by Bacillus amyloliquefaciens (trade name: Neutrase), and peptidase produced by the genus Bacillus (trade name: Protamex).

[0036] Enzyme treatment to reduce the allergenicity of royal jelly can be carried out, for example, according to the description in JP-A-2007-295919 and JP-A-2007-295920.

[0037] Royal jelly extract is obtained by extracting royal jelly (including raw, dried and crushed royal jelly) with water or aqueous ethanol or the like.

[0038] The royal jelly fermented product can be produced by a conventional method using microorganisms such as yeast and lactic acid bacteria.

[0039] The content of royal jelly in the composition of this embodiment may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, or 0.2% by mass or more, relative to the total amount of the composition, and may be 10% by mass or less, 5% by mass or less, 1% by mass or less, or 0.5% by mass or less.

[0040] Butylene glycol is a compound also called butanediol, and is a substance that is often used as a moisturizing agent.In this specification, butylene glycol refers to 1,3-butylene glycol.The content of butylene glycol in the composition according to this embodiment may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, 6% by mass or more, 7% by mass or more, or 8% by mass or more, and may be 30% by mass or less, 25% by mass or less, 20% by mass or less, 15% by mass or less, or 10% by mass or less.

[0041] Pentylene glycol is a compound also called 1,2-pentanediol, and is often used as a moisturizing agent.The content of pentylene glycol in the composition according to this embodiment can be, for example, 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, or 2% by mass or more, and can be 10% by mass or less, 8% by mass or less, 6% by mass or less, 4% by mass or less, or 2.5% by mass or less.

[0042] The composition according to the present embodiment may further contain a lactobacillus fermentation extract of honey, which reduces the contact angle of water with the skin to which the composition according to the present embodiment is applied, thereby improving skin compatibility.

[0043] The honey lactobacillus fermentation extract is obtained by fermenting honey with lactobacillus, and is preferably obtained by fermenting honey and chamomile flowers with lactobacillus.

[0044] Chamomile is a plant of the Asteraceae family (Compositae or Asteraceae) and its scientific name is Matricaria chamomilla L. or Matricaria recutita L.

[0045] The chamomile flowers to be fermented may be the ones obtained by harvesting the chamomile flowers themselves, or may be processed products of the chamomile flowers. Examples of processed products of the chamomile flowers include processed products obtained by subjecting the chamomile flowers to treatments such as drying, crushing, extraction, etc. These treatments may be performed alone or in combination of two or more.

[0046] The processed chamomile flower may be, for example, a dried product, a crushed product, a powder, an extract, etc. of chamomile flower. The drying of chamomile flower can be carried out, for example, by sun drying, hot air drying, freeze drying, spray drying, etc. The crushing and crushing can be carried out, for example, by using a crusher, a crusher, etc. The chamomile flower is preferably a dried powder of chamomile flower. The dried powder of chamomile flower can be obtained, for example, by drying and further crushing the chamomile flower. The chamomile flower is preferably dried and crushed immediately after harvesting. As the processed chamomile flower, a commercially available product can be used.

[0047] The chamomile flower extract can be obtained by extracting chamomile flowers using a method generally used for plant extraction. For example, an extract can be obtained by putting the chamomile flowers, which are the extraction raw material, into a treatment tank filled with an extraction solvent, stirring appropriately as necessary to elute the soluble components, and then filtering to remove the extraction residue.

[0048] As the chamomile flower extract, the extract obtained by extracting chamomile flowers may be used as it is, or it may be used after further treatment such as dilution, concentration, drying, filtration, purification, etc.

[0049] The extraction solvent may be, for example, an aqueous solvent or a hydrophilic organic solvent. Examples of the aqueous solvent include pure water, purified water, tap water, well water, mineral water, hot spring water, spring water, fresh water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered physiological saline, etc. Examples of the hydrophilic organic solvent include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; and polyhydric alcohols having 2 to 5 carbon atoms such as 1,3-butylene glycol, propylene glycol, and glycerin. The extraction solvent may be used alone or in combination of two or more of these.

[0050] The fermentation of honey or the fermentation of honey and chamomile flowers is carried out using lactobacillus bacteria, such as bacteria belonging to the genus Lactobacillus, more specifically, Lactobacillus kunkeii.

[0051] Lactobacillus kunkeii is preferably one that can utilize glucose and fructose, and more preferably one that can utilize glucose, fructose, sucrose, trehalose, and gluconate. Lactobacillus kunkeii may be Lactobacillus kunkeii BPS402. Lactobacillus kunkeii BPS402 has been deposited on October 3, 2011 at the National Institute of Advanced Industrial Science and Technology (6 Chuo, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan (postal code 305-8566)) under the accession number FERM P-22177 and is available. The strain has also been transferred to an international depository, and is currently under the accession number FERM BP-11439.

[0052] The lactobacillus used for fermentation can be cultured according to a conventional method. There is no particular limitation on the medium as long as the bacteria can be cultured in the medium, and a natural medium, a synthetic medium, a semi-synthetic medium, etc. can be used. The medium can contain a nitrogen source and a carbon source. Examples of the nitrogen source include meat extract, peptone, casein, yeast extract, gluten, soybean flour, soybean hydrolysate, amino acids, etc., and examples of the carbon source include glucose, lactose, fructose, inositol, sorbitol, water, starch, koji soup, bran, bagasse, molasses, etc. In addition, inorganic substances (e.g., ammonium sulfate, potassium phosphate, magnesium chloride, salt, calcium carbonate, iron, manganese, molybdenum), various vitamins, etc. can be added.

[0053] The culture temperature may be, for example, 4 to 45°C, preferably 25 to 40°C, and more preferably 28 to 33°C. The culture time may be, for example, 8 to 72 hours. The culture may be performed by aeration shaking or aeration stirring. The pH of the medium may be, for example, 4.0 to 9.0, and preferably 6.0 to 8.0. As a culture method, for example, the cells are inoculated into MRS medium and cultured at 30°C for 48 hours.

[0054] The culture solution obtained by culturing lactobacillus may be used for fermentation as it is by seeding it on a fermentation medium containing honey or a fermentation medium containing honey and chamomile flowers, or it may be used after diluting it with a medium or the like.

[0055] Fermentation of honey with lactobacillus or fermentation of honey and chamomile flowers can be carried out, for example, at 4 to 45° C., preferably at 25 to 40° C. The fermentation time may be, for example, 12 to 60 hours, preferably 24 to 48 hours. The pH of the honey content at the start of fermentation may be, for example, 3 to 8, preferably 4 to 6. Fermentation may be carried out by aeration shaking or aeration stirring.

[0056] The fermentation of honey or honey and chamomile flowers can be carried out by culturing lactobacillus bacteria in a fermentation medium containing honey or in a fermentation medium containing honey and chamomile flowers. The fermentation medium containing honey or honey and chamomile flowers may be in any form that allows lactobacillus bacteria to ferment, for example, in the form of a liquid, paste, gel, etc. The fermentation medium may be, for example, a solvent such as water in which honey or honey and chamomile flowers are dissolved or suspended.

[0057] The honey concentration in the fermentation medium at the start of fermentation may be, for example, 0.1 to 40%, 1 to 30%, or 8 to 13% based on the total volume of the fermentation medium. The honey concentration in the fermentation medium at the start of fermentation may be, for example, 0.08 to 32%, 0.8 to 24%, or 6.4 to 10.4% based on the total volume of the fermentation medium, as a solid content.

[0058] The concentration of chamomile flowers in the fermentation medium at the start of fermentation may be, for example, 0.01 to 20%, 0.1 to 5%, or 0.5 to 2% as a solid content relative to the total amount of the fermentation medium. The mass ratio of honey (total amount) to chamomile flowers (dry mass) in the fermentation medium at the start of fermentation may be, for example, 4000:1 to 1:200, or 26:1 to 4:1. The fermentation medium may further contain known nutrients required for the culture of lactic acid bacteria, such as vitamins, amino acids, minerals, salts, surfactants, fatty acids, and metals. The honey used for fermentation may be sterilized by heating or the like.

[0059] The honey Lactobacillus fermentation extract or the honey and chamomile flower Lactobacillus fermentation extract may be directly obtained by fermentation, or may be subjected to treatment such as heating, filtration, purification, concentration, evaporation to dryness, freeze-drying, spray-drying, etc. The honey Lactobacillus fermentation extract or the honey and chamomile flower fermentation extract may contain live and / or dead Lactobacillus cells, or the cells may have been separated and removed by filtration or the like.

[0060] The composition according to this embodiment may be, for example, a cosmetic product or a cosmetic raw material.

[0061] The cosmetic raw material may be in any form, such as a solid, liquid, or paste. The cosmetic may be a medicated cosmetic (i.e., a quasi-drug). The cosmetic includes any cosmetic that can be applied to the skin of an animal (especially a human).

[0062] The cosmetic product may contain honey, royal jelly, butylene glycol, pentylene glycol, lactobacillus fermentation extract of honey, or lactobacillus fermentation extract of honey and chamomile flower, as well as other cosmetically acceptable ingredients, such as whitening agents, moisturizing agents, antioxidants, oily ingredients, ultraviolet absorbing agents, surfactants, thickeners, alcohols, powdery ingredients, coloring materials, aqueous ingredients, water, and various skin nutrients.

[0063] The dosage form of the cosmetic product may be, for example, a solubilized system, an emulsion system, a powder system, an oil system, a gel system, an ointment system, an aerosol system, a water-oil two-layer system, a water-oil-powder three-layer system, etc. The cosmetic product may be, for example, a face wash, a lotion, a milky lotion, a cream, a gel, an essence, a beauty serum, a pack, a mask, a mist, a UV protection cosmetic, or other basic cosmetic product, a foundation, a lipstick, a blusher, an eye shadow, an eyeliner, a mascara, or other make-up cosmetic product, a face wash, a massage agent, a cleansing agent, an aftershave lotion, a preshave lotion, a shaving cream, a body soap, a soap, a hand cream, a hand soap, etc.

[0064] The composition according to the present embodiment is particularly suitable for use as a booster beauty serum (introduction liquid (introduction beauty serum)) or as a raw material thereof. A booster beauty serum improves the skin compatibility of cosmetics such as lotion and emulsion that are applied after the application of the beauty serum. Since the composition according to the present embodiment improves skin compatibility, it can be suitably used in cosmetics for such purposes.

[0065] The dosage of the composition according to this embodiment when administered parenterally may be once a day, or may be divided into multiple doses, such as twice or three times a day. The dosage may vary depending on the health condition of the subject, the combination with other compositions, or the site and range of application, and can be arbitrarily set by those skilled in the art as necessary. For example, the dosage when administered once to the skin is 0.001 to 10 mg / cm. 2 and may be 0.001 to 8 mg / cm 2 is preferable, and 0.001 to 6 mg / cm 2 is more preferred.

[0066] The method for producing the composition according to the present embodiment is not particularly limited, and can be any known method. For example, the composition for the above purpose can be obtained by mixing honey, or, if necessary, royal jelly, butylene glycol, pentylene glycol, or honey fermentation extract with an intermediate product or final product in the manufacturing process of cosmetics.

[0067] [How to improve skin compatibility] A method for improving skin compatibility according to one embodiment includes applying the honey to skin. By applying the honey, skin compatibility is improved compared to when the honey is not applied to the skin. The method for improving skin compatibility may further include applying the royal jelly, the butylene glycol, and the pentylene glycol to the skin. The method for improving skin compatibility may also include further applying a lactobacillus fermentation extract of the honey. EXAMPLES

[0068] The present invention will be described in more detail below with reference to examples, although the present invention is not limited to the following examples.

[0069] [Test example: Evaluation of skin compatibility improvement effect by measuring water contact angle] According to the following procedure, the contact angle of water on the skin to which each sample shown in Table 1 was applied was measured, and the effect of improving skin compatibility was evaluated.

[0070] 0.1 g of samples 1 to 5 shown in Table 1 was applied to a 5 cm x 5 cm area on a Bioskin plate (manufactured by Viewlux), and then each sample was dried for at least 1 hour. Next, 2 μl of water was dropped onto the area where each sample was applied, and the contact angle of water after 1000 milliseconds was measured by the sessile drop method. The contact angle of water was measured using an automatic contact angle meter DMo-602 (manufactured by Kyowa Interface Science Co., Ltd.) and analyzed by the θ / 2 method. The results are shown in Table 2.

[0071] [Table 1]

[0072] [Table 2]

[0073] When no application was made, the contact angle of water on the skin was 92 degrees. On the other hand, the contact angle of water on the skin after application of samples 1 and 2 was 30 degrees or less. This suggests that applying honey to the skin improves subsequent skin compatibility. In addition, the contact angle of water on the skin after application of sample 5 was smaller than the contact angle of water on the skin after application of samples 1 and 2. This suggests that applying royal jelly, butylene glycol, pentylene glycol, and honey and lactobacillus fermentation extract of chamomile flowers in addition to honey to the skin improves skin compatibility.

Claims

1. A composition for improving skin compatibility, comprising honey, wherein the contact angle of water with the skin to which the composition is applied is 30 degrees or less.

2. 10. The composition of claim 1 further comprising royal jelly, butylene glycol and pentylene glycol.

3. The composition of claim 2 further comprising a lactobacillus fermentation extract of honey.

4. The composition according to claim 3, wherein the honey lactobacillus fermentation extract is obtained by fermenting honey and chamomile flowers with Lactobacillus kunkii.

5. A composition according to any one of claims 1 to 4, wherein the honey is manuka honey and / or acacia honey.

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