Topical skin preparation

Abstract

To provide a topical skin preparation that not only improves texture, transparency and moisturizing feeling of a skin and exhibits preventative and improvement effects on aging but also keeps the skin in a youthful and healthy state, with reduced irritation to the skin as well as an excellent feeling of use.SOLUTION: Provided is a topical skin preparation that contains, as an active ingredient, a composition containing a niacinamide, a bamboo shoot extract and a perilla leaf extract.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an external skin preparation that exhibits higher effectiveness by combining a plurality of ingredients. [Background technology]

[0002] Conventionally, the use of various compounds has been proposed as ingredients that can be incorporated into skin external preparations, and skin external preparations (external medicines, quasi-drugs, cosmetics, etc.) containing these compounds have been marketed. For example, antioxidants such as vitamin C and vitamin E; anti-inflammatory agents such as glycyrrhizic acid; various ultraviolet absorbers; cell activating ingredients such as α-hydroxycarboxylic acid, placental extract, and γ-amino-β-hydroxybutyric acid; extracellular matrix ingredients such as collagen, elastin, and hyaluronic acid; and moisturizing agents such as urea have been proposed. On the other hand, in consideration of safety, skin external preparations containing various plant-derived ingredients have been proposed. However, the effectiveness of these compounds and plant-derived ingredients alone is not sufficient, and a combination of ingredients that exhibit high effectiveness is required. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 2022-138725 Summary of the Invention [Problem to be solved by the invention]

[0004] In view of the problems of the above-mentioned conventional techniques, the present inventors have conducted extensive research into combinations of highly effective compounds and plant-derived ingredients as active ingredients for skin external preparations. As a result, they have found that a combination of niacinamide (also known as nicotinamide), bamboo shoot extract, and perilla extract is highly effective as an ingredient in skin external preparations. Conventionally, a technique for blending niacinamide and bamboo shoot extract into skin external preparations is known from Patent Document 1, but it has not been known that a more effective skin external preparation can be provided by combining niacinamide, bamboo shoot extract, and perilla extract. [Means for solving the problem]

[0005] The present invention is a skin external preparation containing a composition containing niacinamide, bamboo shoot extract, and perilla extract as active ingredients. Furthermore, the skin topical preparation of the present invention may further contain one or more of glycyrrhizinic acid or a derivative thereof, tranexamic acid or a derivative thereof, ascorbic acid or a derivative thereof, pantothenyl alcohol, and tocopherol or a derivative thereof. Effect of the Invention

[0006] The present invention provides an external skin preparation that exhibits effects such as improved skin texture and transparency, moisturizing effect, and wrinkle reduction by combining niacinamide, bamboo shoot extract, and perilla extract as active ingredients. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] Next, the "bamboo shoots" used in the present invention will be described. "Bamboo shoots" are young shoots of bamboo belonging to the Poaceae family, Bambusoideae subfamily. The parts of bamboo shoots used in the present invention may be edible parts, the skin of the inedible parts, or bamboo water.

[0008] Examples of bamboos of the Poaceae subfamily Bambusoideae that can be used in the present invention include Phyllostachys pubescens, Phyllostachys bambusoides, Phyllostachys nigra, Phyllostachys aurea, Phyllostachys heterocycla, Bambusa multiplex, Semiarundinaria fastuosa, Sasa kurilensis, Sinobambusa tootsik, Chimonobambusa quadrangularis, Chimonobambusa marmorea, Pseudosasa japonica, Pleioblastus simonii), but the present invention is not limited thereto.

[0009] In the present invention, bamboo shoots refer to young shoots of bamboos of the Poaceae subfamily. The bamboo shoots preferred for use in the present invention vary depending on the bamboo species. For example, in the case of Moso bamboo, those harvested from early March to late June before the young shoots appear above ground are preferred. In the case of Madake, those harvested from June to September with an aboveground part of 10 to 500 cm are preferred, and those 30 to 200 cm above ground are more preferred. In addition, when the bamboo shoots grow beyond the above-mentioned range, the edible part and skin of the young shoots become hard, and the amount of tyrosine, which is undesirable as a cosmetic ingredient, increases, making them unsuitable for the present invention.

[0010] The extract can be prepared by first washing the skin or edible parts of the bamboo shoots with water if necessary to remove foreign matter, then either as is or dried, and then shredded or crushed as necessary, and contacting them with an extraction solvent according to a conventional method such as the soaking method.

[0011] In the present invention, "perilla" refers to perilla of the genus Perilla in the family Lamiaceae, and generally includes those represented by the scientific name Perilla frutescens var. crispa or Perilla frutescens var. Britton, such as Perilla aorticulatus, Perilla chirimen shiso, Perilla akasan, Perilla madara, Perilla katamen shiso, Perilla chirimen aorticulatus, or their variants, subspecies, or hybrids, but the present invention is not limited thereto. The part to be used may be the whole plant, leaves, inflorescences, stems, seeds, fruits, roots, etc., but it is preferable to use leaves or the whole plant including leaves. In addition, the harvest time and size of the part of perilla to be used are not particularly limited, and any size or harvest time may be used.

[0012] Examples of extraction solvents used in preparing bamboo shoot and perilla extracts include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; esters such as ethyl acetate, butyl acetate, and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene, and chloroform, and these may be used alone or in combination of two or more.

[0013] Among these extraction solvents, the use of water or a mixed solvent of water and a lower alcohol or water and a polyhydric alcohol is preferred in the present invention, since it can be widely applied to external preparations for skin.

[0014] In preparing the extract, the pH of the extract is not particularly limited, but is preferably in the range of pH 2 to 8. In preparing the bamboo shoot extract, the pH is more preferably in the range of pH 2 to 4 in order to suppress the elution of "tyrosine" contained in the bamboo shoot. Therefore, in preparing the bamboo shoot extract, examples of the pH adjustment agents include acidity adjusters such as lactic acid, citric acid, hydrochloric acid, phosphoric acid, and sulfuric acid.

[0015] The extraction conditions such as extraction temperature and extraction time vary depending on the type and pH of the solvent used. For example, in the case of a immersion method using water as the extraction solvent, the extraction temperature is generally 1 to 90°C, preferably in the range of 5°C to 80°C, and the extraction time is generally 0.5 to 7 days, preferably in the range of 1 to 24 hours.

[0016] The extract obtained under the above conditions may generally be adjusted to a pH of 4 to 8 and used as is as an ingredient of an external skin preparation, or may be concentrated under reduced pressure or the like to a desired concentration.

[0017] When the composition containing niacinamide, bamboo shoot extract and perilla extract according to the present invention is incorporated into an external preparation for skin, in addition to the composition which is the essential component, components usually used in external preparations for skin (cosmetics, quasi-drugs or external medicines) can be appropriately incorporated as necessary, such as oily components, surfactants (synthetic or natural), moisturizers, thickeners, emulsifiers or emulsifier assistants, preservatives / bactericides, powder components, ultraviolet absorbers, antioxidants, sequestering agents, pigments, fragrances, anti-wrinkle agents, pigmentation prevention agents and other physiologically active components.

[0018] Examples of oily components include plant-derived oils such as olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cocoa oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, bergamot oil, lavender oil, rose oil, bergamot oil, chamomile oil, lemon peel oil, camphor bark oil, mandarin orange oil, cardamom oil, and orange oil; vitamin A oil; animal-derived oils such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, and lanolin; liquid paraffin, Examples of the fatty acids include petrolatum, paraffin wax, squalane, etc.; myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid, etc.; higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, stearyl alcohol, etc.; synthetic esters and synthetic triglycerides such as isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexyl glyceride, and higher fatty acid octyldodecyl (e.g., octyldodecyl stearate), etc.

[0019] Examples of the surfactant include nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene Examples of usable surfactants include anionic surfactants such as ethylene alkyl phenyl ether phosphates; cationic surfactants such as quaternary ammonium salts, primary to tertiary fatty amine salts, trialkyl benzyl ammonium salts, alkyl pyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethyl imidazolinium salts, N,N-dialkyl morpholinium salts, and polyethylene polyamine fatty acid amide salts; and amphoteric surfactants such as N,N-dimethyl-N-alkyl-N-carboxymethyl ammonio betaine, N,N,N-trialkyl-N-alkylene ammonio carboxybetaine, N-acylamidopropyl-N', N'-dimethyl-N'-β-hydroxypropyl ammonio sulfobetaine, and the like.

[0020] Examples of emulsifiers or emulsification aids that can be blended include stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), sugar and protein complexes, sucrose or its esters, lactose, soy-derived water-soluble polysaccharides, soy-derived protein and polysaccharide complexes, lanolin or its derivatives, cholesterol, stevia derivatives (enzyme-treated stevia, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponin and its derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, millet, etc.), etc.

[0021] Examples of moisturizing agents include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and the like, as well as sugars such as trehalose and raffinose, mucopolysaccharides (e.g., hyaluronic acid and its derivatives, hyaluronic acid fermentation liquid, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea, higher fatty acids octyldodecyl, seaweed extracts, estradiol, various amino acids and their derivatives.

[0022] Examples of thickening agents include components derived from brown algae, green algae, or red algae, such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin, pullulan, and aloe polysaccharides; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum; cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl cellulose; synthetic polymers such as carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid-methacrylic acid copolymers; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives, and polyacrylic acid.

[0023] Anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, and riboflavin or a derivative thereof.

[0024] Examples of preservatives and disinfectants include urea; benzoic acid or its salts, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, and alkane bromide. These include kilisoquinolinium, resorcinol, jamal (imidazolidinyl urea), isopropyl methylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil and eucalyptus oil, bark distillate, fermented radish liquid, ethanol derived from plants such as sugar cane and corn, or 1,3-butylene glycol.

[0025] Examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol.

[0026] Anti-acne agents include, for example, sulfur, salicylic acid or its salts, photosensitizer No. 201, pyridoxine dicaprylate, isopropyl methylphenol, and the like.

[0027] Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, cellulose-based powder, powder of grains (rice, wheat, corn, millet, etc.), powder of beans (soybeans, adzuki beans, etc.), and the like.

[0028] Examples of ultraviolet absorbers include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, and aloe extract.

[0029] Examples of antioxidants include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, carotenoids such as astaxanthin, vitamin E and its derivatives (e.g., tocopherol acetate, tocopherol nicotinate), vitamin A and its derivatives (retinol palmitate, etc.), and the like.

[0030] Examples of sequestering agents include disodium edetate, trisodium edetate, tetrasodium edetate, etidronic acid or a salt thereof (e.g., tetrasodium etidronic acid), gluconic acid or a salt thereof (e.g., sodium gluconate), diethylenetriaminepentaacetic acid or a salt thereof (e.g., pentasodium diethylenetriaminepentaacetic acid), hydroxyethanediphosphonic acid or a salt thereof (e.g., tetrasodium hydroxyethanediphosphonic acid), and phytic acid or a salt thereof (e.g., sodium phytate).

[0031] Examples of pigmentation prevention agents include one or more selected from kojic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, resorcinol derivatives, 4-methoxysalicylic acid potassium salt, vitamin E or its derivatives, nicotinic acid or its derivatives, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine monophosphate, adenosine monophosphate), placenta extract, and linoleic acid.

[0032] Examples of the kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, kojic acid ethers, and kojic acid sugar derivatives such as kojic acid glucoside. Examples of the ascorbic acid derivatives include sodium L-ascorbic acid 2-phosphate, magnesium L-ascorbic acid 2-phosphate, sodium L-ascorbic acid 2-sulfate, and L-ascorbic acid 2-sulfate. Ascorbic acid ester salts such as magnesium, ascorbic acid sugar derivatives such as L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O-α-D-glucopyranosyl-L-ascorbic acid), 6-acylated derivatives of these ascorbic acid sugar derivatives (the acyl group is a hexanoyl group, an octanoyl group, a decanoyl group, etc.), L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, etc. Examples of the hydroquinone derivatives include arbutin (hydroquinone-β-D-glucopyranoside) and α-arbutin (hydroquinone-α-D-glucopyranoside). Examples of the resorcinol derivatives include, for example, 4-n-butylresorcinol and 4-isoamylresorcinol. Examples of 2,5-dihydroxybenzoic acid derivatives include 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, etc.; examples of nicotinic acid derivatives include nicotinamide and benzyl nicotinate; examples of vitamin E derivatives include vitamin E nicotinate and vitamin E linoleate; and examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctanoic acid.

[0033] Anti-wrinkle agents include vitamin A or its derivatives, vitamin E or its derivatives (tocopherol acetate, etc.), ascorbic acid or its derivatives (ascorbic acid glucoside, 3-O-ethyl ascorbic acid, ascorbic acid phosphate magnesium salt, etc.), D-pantothenyl alcohol, tranexamic acid, etc.

[0034] In the present invention, it is also suggested that synergistic effects such as wrinkle improvement and whitening effects can be exhibited by using niacinamide, bamboo shoot extract, and perilla extract in combination with dipotassium glycyrrhizinate, ascorbic acid or a derivative thereof, kojic acid or a derivative thereof, tranexamic acid or a derivative thereof, arbutin, tocopherol or a derivative thereof, D-pantothenyl alcohol, etc.

[0035] The application site of the skin external preparation (including cosmetics, quasi-drugs, and external medicines) containing the composition containing niacinamide, bamboo shoot extract, and perilla extract according to the present invention includes the whole skin including the scalp, and is not particularly limited.Therefore, the dosage form includes, for example, milky lotion, cream, lotion, essence, pack, lipstick, foundation, liquid foundation, makeup press powder, blusher, face powder, face wash, body shampoo, soap, preparation for mask, and bath agent, but the present invention is not limited thereto.

[0036] The present invention will now be described in more detail with reference to Production Examples, Formulation Examples, Examples and Test Examples, but the present invention is not limited thereto. In the following, all parts are by weight and all % are by weight.

[0037] Production Example 1. Bamboo shoot extract (1) 100 g of dried and ground bamboo shoot skin was added with 1000 g of purified water and 0.92 g of lactic acid, and extraction was carried out at 40°C for 4 hours. The extract was then filtered to obtain 533 g of a light brown bamboo shoot skin extract solution (solid content concentration 0.61%).

[0038] Production Example 2. Bamboo shoot extract (2) 1000g of purified water was added to 100g of dried and ground bamboo shoot skin, and extraction was carried out at 40°C for 4 hours. The extract was then filtered to obtain 520g of a light brown bamboo shoot skin extract solution (solid content concentration 0.49%).

[0039] Production Example 3. Bamboo shoot extract (3) In Production Example 1, 639 g of a light brown transparent madake extract (solid content concentration 0.58%) was obtained by the same process as in Production Example 2, except that 100 g of dried and ground madake (Phyllostachys bambusoides) bamboo shoot bark was used instead of moso bamboo.

[0040] Production Example 4. Preparation of perilla extract (1) 400 g of purified water was added to 40 g of dried perilla leaves and extracted for 18 hours at 10° C. This was filtered to obtain 336 g of a brown extract (solid content 2.35%).

[0041] Production Example 5. Preparation of perilla extract (2) 400 g of 30% 1,3-butylene glycol aqueous solution was added to 40 g of dried perilla leaves, and extraction was carried out for 18 hours at 10° C. This was filtered to obtain 342 g of a brown extract (solid content 2.40%).

[0042] Production Example 6. Preparation of perilla extract (3) 400 g of 20% ethanol aqueous solution was added to 40 g of dried perilla leaves and extracted for 18 hours at 10° C. This was filtered to obtain 348 g of a brown extract (solid content 2.45%).

[0043] Test Example 1. Evaluation test of epidermal cell proliferation promoting effect Normal human epidermal cells (NHEK) (purchased from Kurabo) were cultured at 8 × 10 in a 96-well microplate containing HuMedia-KG2 (Kurabo). 3 The cells were seeded at 10 cells / well and incubated at 37°C, 5.0% CO 2After pre-cultivation for 1 day under the above conditions, the culture medium was replaced with 150 μL of HuMedia-KB2 (Kurabo). 50 μL of PBS(-) containing the extract of Production Example 4 or Production Example 5 as a sample solution was added, and the culture was continued for another 2 days under the same conditions. The concentration of the sample solution was adjusted so that the final concentration as a solution in the medium was 0.5%, 1.0%. After the culture was completed, the supernatant was discarded and the cells were washed once with PBS(-), and then 100 μL / well of Hoechst 33342 reagent diluted 500 times with PBS(-) was added and incubated at 37° C. for 30 minutes to fluorescently stain the DNA. Thereafter, the fluorescence intensity [excitation wavelength: 355 nm, fluorescence wavelength: 460 nm: fluorescence microplate reader (Fluoroscan Ascent, Thermo Fisher Scientific)] was measured to determine the amount of DNA. The same procedure was performed on a control group to which 30% 1,3-butylene glycol was added at 1.0% instead of the above sample solution, and the relative fluorescence intensity (DNA amount) of each sample-added group was calculated to obtain the cell proliferation rate (%).

[0044] [Table 1] JPEG2025037673000001.jpg50104

[0045] As shown in Table 1, the extracts of Production Examples 4 and 5 were confirmed to have the effect of promoting the proliferation of epidermal cells. The epidermal cells that proliferate when cultured are the basal cells in the lowest layer of the epidermis, and it is suggested that the proliferation of these basal cells pushes the basal cells up to the upper layers of spinous cells, granular cells, and keratinocytes, normalizing or improving the turnover of the epidermis until the keratin peels off. It is also suggested that the normalization or improvement of this turnover has the effect of improving the texture of the epidermis and improving its transparency, as well as the effect of promoting the discharge of melanin from skin cells and promoting the prevention or improvement of pigmentation such as age spots, freckles, and melasma.

[0046] Test example 2: Monitor test It was confirmed that the extracts of Production Examples 4 and 5 above have the effect of proliferating epidermal cells, and furthermore, the following test confirmed that the combination of niacinamide with the extract of Production Example 1 or Production Example 3 and the extract of Production Example 4 or Production Example 5 exerts the effect of improving skin texture, transparency and moisturizing feeling.

[0047] [Sample preparation] First, inventive samples 1 and 2 and comparative samples 1 to 4 were prepared as follows. Note that % indicates weight % in the sample solution. 1. Sample 1 of the present invention (1) Extract of Production Example 1 (1.0%) (2) Extract of Production Example 4 (1.0%) (3) Niacinamide (5.0% (4) 1,3-butylene glycol (5.0%) (5) Purified water (88.0%) 2. Comparative sample 1 (1) Extract of Production Example 1 (1.0%) (2) Niacinamide (5.0%) (3) 1,3-butylene glycol (5.0%) (4) Purified water (89.0%) 3. Comparative sample 2 (1) Extract of Production Example 4 (1.0%) (2) Niacinamide (5.0%) (3) 1,3-butylene glycol (5.0%) (4) Purified water (89.0%) 4. Sample 1 of the present invention (1) Extract of Production Example 3 (1.0%) (2) Extract of Production Example 5 (1.0%) (3) Niacinamide (5.0% (4) 1,3-butylene glycol (5.0%) (5) Purified water (88.0%) 5. Comparative sample 3 (1) Extract of Production Example 3 (1.0%) (2) Niacinamide (5.0%) (3) 1,3-butylene glycol (5.0%) (4) Purified water (89.0%) 6. Comparative sample 4 (1) Extract of Production Example 5 (1.0%) (2) Niacinamide (5.0%) (3) 1,3-butylene glycol (5.0%) (4) Purified water (89.0%)

[0048] [Test Method] Ten randomly selected male and female subjects aged 25 to 60 years were divided into two groups. In group A, two test areas were applied to the forearm of each subject, and two comparison areas were applied to comparative samples 1 and 2. In addition, one control area (5% 1,3-butylene glycol aqueous solution) was set. Each test area was applied twice a day (morning and evening) for 14 days, and the subjects were asked to evaluate (a) texture, (b) transparency, and (c) moisturizing sensation on a four-point scale: A: very good, B: good, C: no change, D: slightly bad. In group B, two test areas were applied to the forearm of each subject, and two comparison areas were applied to comparative samples 3 and 4. In addition, one control area (5% 1,3-butylene glycol aqueous solution) was set. Each test area was applied twice a day (morning and evening) for 21 days, and the same evaluation was performed.

[0049] The results of Test Example 2 are shown in Table 2. [Table 2] JPEG2025037673000002.jpg8696

[0050] [Table 3] JPEG2025037673000003.jpg8796

[0051] As shown in Tables 2 and 3, it was confirmed that the samples of the present invention containing niacinamide, the extract of Production Example 1 or Production Example 2, and the extract of Production Example 4 or Production Example 5 exhibit the effect of improving skin texture, transparency, and moisturizing feeling. From this result, it was confirmed that wrinkles caused by dryness of the epidermis can also be improved. Furthermore, since niacinamide is known to have the effect of improving wrinkles and sagging of the dermis, it is suggested that the composition of the present invention also has the effect of preventing and improving aging of both the epidermis and dermis.

[0052] The following are examples of formulations of skin external preparations (cosmetics, quasi-drugs, etc.) containing the composition according to the present invention, but the present invention is not limited thereto. In addition to the composition according to the present invention, as shown in the following formulation examples, it is more preferable to use in combination with one or more of "glycyrrhizinic acid or its derivatives," "tranexamic acid or its derivatives," "ascorbic acid or its derivatives," "pantothenyl alcohol," and "tocopherol or its derivatives," which are known to have effects of preventing or improving rough skin and preventing or improving pigmentation.

[0053] Formulation example 1. Lotion [Ingredients] Part Squalane 0.1 Niacinamide 5.0 Extract of Preparation Example 1 0.5 Extract of Preparation Example 4 0.5 Dipotassium glycyrrhizinate 0.5 Sodium citrate 0.2 Phenoxyethanol 0.05 Pentanediol 0.05 1,3-butylene glycol 0.3 Purified water (enough to make the total amount 100 parts)

[0054] Formulation example 2: Lotion [Ingredients] Part Squalane 0.1 Niacinamide 5.0 Extract of Preparation Example 3 0.5 Extract of Preparation Example 5 0.5 Dipotassium glycyrrhizinate 0.5 Sodium citrate 0.2 Phenoxyethanol 0.05 Pentanediol 0.05 1,3-butylene glycol 0.3 Purified water (enough to make the total amount 100 parts)

[0055] Formulation example 3. Lotion [Ingredients] Part Jojoba oil 1.0 Polyoxyethylene (5.5) Cetyl Alcohol 5.0 Niacinamide 3.0 Tranexamic acid 2.0 Extract of Preparation Example 1 0.5 Extract of Preparation Example 4 0.5 Glycerin 5.0 1,3-Butylene glycol 5.0 Sodium citrate 0.2 Sodium pyrosulfite 0.05 Methylparaben 0.1 Purified water (enough to make the total amount 100 parts)

[0056] Formulation example 4. Emulsion [Ingredients] Part Squalane 5.0 Hexalan 3.0 Hexyldecyl Isostearate 1.0 Caprylic / Capric Triglyceride 1.0 Polyglyceryl-10 Laurate 5.0 Polyglyceryl-10 Isostearate 5.0 Ascorbyl Dipalmitate 15.0 Hydrogenated soy lecithin 1.5 Niacinamide 5.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 Ascorbic Acid-2 Glucoside 2.0 D-Pantothenyl alcohol 0.3 Glycerin 3.0 1,3-Butylene glycol 2.0 Carboxymethylcellulose 0.3 Xanthan gum 0.2 Tremella polysaccharide 0.2 Sodium hyaluronate 0.01 Tocopherol acetate 0.3 Tocopherol nicotinate 0.1 Dipotassium glycyrrhizinate 0.1 Isopropyl methylphenol 0.1 Water-soluble collagen 0.1 Hydrolyzed Collagen 0.1 Sodium hyaluronate 0.01 Purified water (enough to make the total amount 100 parts)

[0057] Formulation example 5. Emulsion A milky lotion was obtained in the same manner as in Formulation Example 4, except that 2.0 parts of L-ascorbyl magnesium phosphate was used in place of 2.0 parts of ascorbic acid glucoside.

[0058] Formulation example 5. Emulsion An emulsion was obtained in the same manner as in Formulation Example 4, except that 2.0 parts of 3-O-ethyl ascorbic acid was used in place of 2.0 parts of ascorbic acid glucoside.

[0059] Formulation example 6. Cream [Ingredients] Part Olive oil 5.0 Jojoba oil 5.0 Squalane 5.0 Hexyldecyl Isostearate 5.0 Di(octyldodecyl / phytosteryl / behenyl) lauroyl glutamate 5.0 Glyceryl Caprylate 1.0 Glyceryl stearate 1.0 Isostearyl glyceryl 3.0 Niacinamide 5.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 γ-Oryzanol 0.1 Behenyl Alcohol 2.0 Palmitic acid 2.5 D-Pantothenyl Alcohol 3.0 Allantoin 0.1 Riboflavin 0.01 Resorcinol 0.1 Benzalkonium chloride 0.05 Urea 3.0 β-Glycyrrhetinic acid 0.1 Stearyl Glycyrrhetinate 0.1 Ammonium glycyrrhizinate 0.1 Lactic acid fermented rice 2.0 Hydrogenated lecithin 0.5 Hydrogenated lysolecithin 0.5 Oil-soluble ginseng extract 2.0 Xanthan gum 1.0 Zinc oxide 0.5 1,3-Butylene glycol 3.0 Pentanediol 0.1 Purified water (enough to make the total amount 100 parts)

[0060] Prescription example 7. Pack [Ingredients] Part Dipropylene glycol 5.0 Polyoxyethylene (60) hydrogenated castor oil 5.0 Cetanol 3.0 Behenyl Alcohol 3.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Ammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.1 Stearyl Glycyrrhetinate 0.1 Salicylic acid 0.1 Tocopherol acetate 0.1 Tocopherol nicotinate 0.1 D-Pantothenyl alcohol 0.3 Resorcinol 0.1 Sulfur 2.0 Estradiol 0.002 Niacinamide 5.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 Xanthan gum 2.0 Polyglyceryl-6 Myristate 1.0 Potassium cocoyl glutamate 1.0 Hydrogenated Lecithin 3.0 Hydroxylated Lecithin 3.0 Purified water (enough to make the total amount 100 parts)

[0061] Formulation example 8. Hair shampoo [Ingredients] Part Sodium Laureth Sulfate 10.0 Glyceryl Monostearate 1.0 Coconut oil fatty acid diethanolamide 2.0 Polyoxyethylene (40) hydrogenated castor oil 0.5 Benzalkonium chloride 1.0 Stearyl Alcohol 2.0 Behenyl Alcohol 2.0 Dimethicone 3.0 Niacinamide 1.0 Extract of Preparation Example 2 1.0 Extract of Preparation Example 6 1.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sodium Salicylate 0.1 Tocopherol acetate 0.1 Pyrithione Zinc 0.3 Benzoic acid 0.2 Triclosan 0.2 Citric acid 0.1 Propylene glycol 2.0 Purified water (enough to make the total amount 100 parts)

[0062] Formulation example 9. Hair conditioner [Ingredients] Part Polyoxyethylene (10) hydrogenated castor oil 1.0 Distearyldimethylammonium chloride 1.5 Stearyltrimethylammonium chloride 2.0 Glyceryl 2-ethylhexanoate 1.0 Benzalkonium chloride 1.0 Cetanol 3.0 Stearyl alcohol 1.0 Niacinamide 1.0 Extract of Preparation Example 3 1.0 Extract of Preparation Example 4 1.0 Allantoin 0.1 Isopropyl methylphenol 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sulfur 0.5 Alkylisoquinolinium bromide solution (75%) 0.06 Pyrithione Zinc 0.3 Methylparaben 0.1 Triclosan 0.2 Resorcinol 0.1 Purified water (enough to make the total amount 100 parts)

[0063] Formulation example 10. Cleansing cosmetics [Ingredients] Part Potassium cocoyl glycine 5.0 Glycerin 10.0 Glyceryl Caprylate 1.0 Sodium lauroyl aspartate 10.0 Niacinamide 5.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 Cetanol 3.0 Myristyl Alcohol 3.0 Isopropyl methyl alcohol 0.1 Allantoin 0.1 Sulfur 0.5 Glycyrrhizic acid 0.1 Dipotassium glycyrrhizinate 0.1 Monoammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.05 Stearyl Glycyrrhetinate 0.1 Salicylic acid 0.2 Tocopherol acetate 0.1 Triclosan 0.1 Trichlorocarbanide 0.5 Trichlorohydroxydiphenyl ether 0.2 Concentrated benzalkonium chloride solution 50 0.2 Benzalkonium chloride 0.1 Purified water (enough to make the total amount 100 parts)

[0064] Formulation example 11. Sheet mask A sheet mask is obtained by impregnating a nonwoven fabric with the following components. [Ingredients] Part Glycerin 3.0 L-Ascorbic Acid 2-Glucoside 2.0 Methylparaben 0.2 Citric acid 0.1 Sodium citrate 0.3 Xanthan gum 1.0 Water-soluble collagen 1.0 Sodium hyaluronate 1.0 Eelgrass extract 1.0 Niacinamide 5.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 0.5 1,3-Butylene glycol 2.0 Hexanediol 0.1 Potassium hydroxide (appropriate amount) Purified water (enough to make the total amount 100 parts)

[0065] Formulation example 12. Beauty serum [Ingredients] Part Ethanol 2.0 Glycerin 5.0 1,3-Butylene glycol 5.0 Methylparaben 0.1 Hyaluronic acid hydrolysate 0.1 Water-soluble collagen 0.1 Ceramide 0.1 Niacinamide 3.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 Citric acid 0.3 Sodium citrate 0.3 Purified water (enough to make the total amount 100 parts)

[0066] Formulation example 13. Wrinkle improvement cream [Ingredients] Part Olive oil 5.0 Squalane 5.0 Jojoba oil 5.0 Jojoba Wax 1.0 Shea Butter 2.0 Behenyl Alcohol 1.0 Stearyl alcohol 1.5 Candelilla Wax 0.5 Niacinamide 5.0 Lactic acid fermented rice 3.0 Extract of Preparation Example 1 1.0 Extract of Preparation Example 4 1.0 Hydrogenated Lecithin 2.0 Eucheuma muscaria extract 2.0 Carboxyvinyl polymer 0.3 Sodium alginate 0.2 Glycerin 4.0 Pentanediol 0.1 Potassium hydroxide (appropriate amount) Purified water (enough to make the total amount 100 parts)

[0067] Formulation example 14. Wrinkle improvement cream A wrinkle-improving cream was obtained in the same manner as in Formulation Example 13, except that, among the ingredients of Formulation Example 13, 1.0 part of the extract of Production Example 3 was used instead of 1.0 part of the extract of Production Example 1, and the extract of Production Example 5 was used instead of the extract of Production Example 4.

Claims

1. A skin topical preparation containing a composition containing niacinamide, bamboo shoot extract, and perilla extract as active ingredients.

2. 2. The skin topical preparation according to claim 1, further comprising one or more of glycyrrhizic acid or a derivative thereof, tranexamic acid or a derivative thereof, ascorbic acid or a derivative thereof, pantothenyl alcohol, and tocopherol or a derivative thereof.

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