External-use composition and method for enhancing fragrance of the same

Abstract

To provide an external-use composition capable of maintaining aroma for a long period of time after application to the skin, and also to provide, with respect to an external-use composition, a method that allows a sufficient fragrance to emerge after application to the skin and maintains that fragrance a long period of time.SOLUTION: An external-use composition contains (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4-position or 5-position, and (B) one or more components selected from the group consisting of (b-1) 1-6-valent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationized polymers.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for external use and a method for enhancing the fragrance thereof. [Background technology]

[0002] In recent years, people, regardless of gender, have become increasingly interested in odor etiquette. Research into various body odors has been conducted in earnest, and the main causes of odors such as sweat odor, armpit odor, foot odor, and aging odor have been identified. As countermeasures against such body odors, methods of masking with perfumes or cosmetics containing aromatic components, a method utilizing the odor-absorbing effect of charcoal (Patent Document 1), a method using an extract from the roots and rhizomes of Sanguinea japonica (Patent Document 2), a method using condensed persimmon tannin (Patent Document 3), and the like have been proposed. Furthermore, a technology for rejuvenating body odor using lactone, a component characteristic of the body odor of young women, is also known (Patent Document 4).

[0003] In fragrance products such as perfumes and cosmetics, the long-lasting fragrance during use is an important factor in providing consumers with a sense of satisfaction, a sense of refreshment, and a sense of elation, and in increasing the value of the product. For this reason, the use of sustained-release fragrances that are designed to hold the fragrance in a carrier is also progressing. However, increasing the amount of such sustained-release fragrances increases the product cost and there is a risk of problems with formulation stability such as coloring. Therefore, there is a strong demand for technology that enhances the fragrance release after application of sustained-release fragrances and efficiently releases fragrance. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2002-145747 A [Patent Document 2] JP 2011-183019 A [Patent Document 3] JP 2001-302483 A [Patent Document 4] International Publication No. 2019 / 059023 Summary of the Invention [Problem to be solved by the invention]

[0005] The present invention has been made in view of the above circumstances, and aims to provide a composition for external use such as a cosmetic product, which, after application to the skin, provides an excellent fragrance from a sustained-release fragrance and further enhances the release of the fragrance. It is also an object of the present invention to provide a method for providing a composition for external use, which, after application to the skin, can provide a sufficient fragrance and further enhance the release of the fragrance. [Means for solving the problem]

[0006] It is known that specific hydroxy fatty acids such as 4-hydroxyundecanoic acid and their salts are cyclized by lipase on the skin under heat or acidic conditions. This specific hydroxy fatty acid itself is unscented, but generates a scent by cyclizing to γ-undecalactone. Since the specific hydroxy fatty acid is thought to generate a scent for a long time by gradually causing the above reaction on the skin, it is expected to be a component that can improve the persistence of the scent after application to the skin. In developing a topical composition containing this specific hydroxy fatty acid, the inventors faced the problem that, depending on the composition and skin condition, the fragrance components generated by cyclization of the hydroxy fatty acid are weak in fragrance, and sufficient fragrance cannot be obtained as a fragrance product. In order to solve this problem, as a result of intensive research, it was found that the above problem is solved and the fragrance is enhanced after application to the skin when a topical composition containing a specific hydroxy fatty acid or a salt thereof is blended with a monohydric to hexahydric alkyl alcohol, an amphiphilic ester, a phenol derivative, or a cationic polymer, and the present invention was completed. That is, the gist of the present invention is as follows.

[0007] [1] (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4th or 5th position, and (B) one or more components selected from the group consisting of (b-1) monohydric to hexahydric alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. A topical composition comprising: [2] The topical composition described in [1], wherein component (A) contains 4-hydroxyundecanoic acid or a salt thereof. [3] In component (B), The component (b-1) is (b-1-1) Monohydric alcohol having 2 carbon atoms (b-1-2) Monohydric or dihydric alcohol with 3 carbon atoms (b-1-3) a trihydric alcohol having 3 carbon atoms, or (b-1-4) containing monohydric to hexahydric alcohols having 4 to 6 carbon atoms; An external composition according to [1] or [2]. [4] The topical composition according to [1] or [2], wherein the component (B) contains one or more components selected from the group consisting of ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol as components (b-1), bisethoxydiglycol cyclohexanedicarboxylate as components (b-2), phenoxyethanol and isopropylmethylphenol as components (b-3), and polyquaternium-10 as component (b-4). [5] (A) A composition for external use containing a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4- or 5-position, (B) A method for enhancing the fragrance of the above-mentioned topical composition after application to the skin, characterized by blending one or more components selected from the group consisting of (b-1) monohydric to hexahydric alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. [6] The method according to [5], wherein component (A) contains 4-hydroxyundecanoic acid or a salt thereof. [7] In the component (B), The component (b-1) is (b-1-1) Monohydric alcohol having 2 carbon atoms (b-1-2) Monohydric or dihydric alcohol with 3 carbon atoms (b-1-3) a trihydric alcohol having 3 carbon atoms, or (b-1-4) containing monohydric to hexahydric alcohols having 4 to 6 carbon atoms; The method according to [5] or [6]. Effect of the Invention

[0008] According to the present invention, it is possible to provide a composition for external use that maintains its fragrance for a long period of time after application to the skin. Furthermore, according to the composition for external use of the present invention, a sufficient fragrance is generated after application to the skin, and the fragrance can be maintained for a long period of time. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The present invention will now be described in detail. In addition, the terms used in this specification are to be interpreted as having the meanings usually used in the technical field unless otherwise specified.

[0010] [External composition] The topical composition of the present invention is characterized by containing (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4th or 5th position (also referred to as "component (A)"), and (B) one or more components selected from the group consisting of (b-1) monovalent to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers (also referred to as "component (B)"). The topical composition of the present invention, having the above composition, can maintain its fragrance for a long time after application to the skin. In addition, according to the topical composition of the present invention, a sufficient fragrance can be obtained after application to the skin, and the fragrance can be maintained for a long time. In addition to the essential components (A) and (B), the topical composition of the present invention may contain (C) a fragrance (excluding component (A)) and other components within the scope of not impairing the effects of the present invention. Each of these will be described in detail below.

[0011] <Component (A)> The topical composition of the present invention contains (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4th or 5th position. The hydroxy fatty acid of the present invention is a hydrocarbon having 10 or more carbon atoms and having a carboxyl group and a hydroxy group, the hydroxy group being at the 4th or 5th position, and is a compound that becomes aromatic when cyclized under heat, acidic conditions, etc. The hydroxy fatty acid of the present invention may have an unsaturated bond, and may be bonded with a substituent such as a methyl group.

[0012] The hydroxy fatty acid of the present invention is preferably one having 10 to 15 carbon atoms, more preferably one having 10 to 13 carbon atoms, and even more preferably one having 10 to 11 carbon atoms. The carbon chain of the hydroxy fatty acid is preferably linear. Examples of the hydroxy fatty acid of the present invention include 4-hydroxydecanoic acid, 4-hydroxyundecanoic acid, 4-hydroxydodecanoic acid, 4-hydroxytridecanoic acid, 4-hydroxytetradecanoic acid, 4-hydroxypentadecanoic acid, 4-hydroxyhexadecanoic acid, 5-hydroxydecanoic acid, 5-hydroxyundecanoic acid, 5-hydroxydodecanoic acid, 5-hydroxytridecanoic acid, 5-hydroxytetradecanoic acid, 5-hydroxypentadecanoic acid, and 5-hydroxyhexadecanoic acid. Among these, from the viewpoint of excellent aromatic properties after cyclization, those having a hydroxy group at the 4-position are preferred, and 4-hydroxydecanoic acid, 4-hydroxyundecanoic acid, and 4-hydroxydodecanoic acid are more preferred, and 4-hydroxyundecanoic acid is even more preferred.

[0013] Examples of the salts of hydroxy fatty acids in the present invention include alkali metal salts and alkaline earth metal salts of the above-mentioned hydroxy fatty acids. Examples of the alkali metal salts include sodium salts and potassium salts. Examples of the alkaline earth metal salts include magnesium salts and calcium salts. Among these, alkali metal salts of hydroxy fatty acids are preferred, and sodium salts of hydroxy fatty acids are more preferred. Specifically, sodium 4-hydroxydecanoate, sodium 4-hydroxyundecanoate, sodium 4-hydroxydodecanoate, sodium 4-hydroxytridecanoate, sodium 4-hydroxytetradecanoate, sodium 4-hydroxypentadecanoate, sodium 4-hydroxyhexadecanoate, sodium 5-hydroxydecanoate, sodium 5-hydroxyundecanoate, sodium 5-hydroxydodecanoate, sodium 5-hydroxytridecanoate, sodium 5-hydroxytetradecanoate, sodium 5-hydroxypentadecanoate, sodium 5-hydroxyhexadecanoate, potassium 4-hydroxydecanoate, potassium 4-hydroxyundecanoate, 4-hydroxypentadecanoate, potassium 5-hydroxyhexadecanoate, potassium 4-hydroxydecanoate, potassium 4-hydroxyundecanoate, potassium 4-hydroxypentadecano ... Examples of the hydroxypropyl 5-hydroxypropyl ester include potassium 4-hydroxydodecanoate, potassium 4-hydroxytridecanoate, potassium 4-hydroxytetradecanoate, potassium 4-hydroxypentadecanoate, potassium 4-hydroxyhexadecanoate, potassium 5-hydroxydecanoate, potassium 5-hydroxyundecanoate, potassium 5-hydroxydodecanoate, potassium 5-hydroxytridecanoate, potassium 5-hydroxytetradecanoate, potassium 5-hydroxypentadecanoate, and potassium 5-hydroxyhexadecanoate. Of these, sodium 4-hydroxydecanoate, sodium 4-hydroxyundecanoate, and sodium 4-hydroxydodecanoate are preferred, and sodium 4-hydroxyundecanoate is more preferred.

[0014] As the component (A) contained in the topical composition of the present invention, either the above-mentioned hydroxy fatty acids or their salts are sufficiently effective, but from the viewpoint of stability in the formulation, the above-mentioned salts of hydroxy fatty acids are preferred.

[0015] Examples of lactones that may be produced on the skin when the topical composition of the present invention is applied to the skin include γ-lactones such as γ-decalactone, γ-undecalactone, and γ-dodecalactone, and δ-lactones such as δ-decalactone, δ-undecalactone, and δ-dodecalactone.

[0016] The content of the component (A) in the topical composition of the present invention is 0.00001% by weight to 10% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.00005% by weight to 8% by weight, more preferably 0.0001% by weight to 5% by weight, even more preferably 0.0005% by weight to 3% by weight, particularly preferably 0.001% by weight to 2% by weight, and even more particularly preferably 0.01% by weight to 1% by weight. When two or more compounds are used in combination as the component (A), the total amount is within the above numerical range.

[0017] <(B) component> The topical composition of the present invention contains, in addition to the above-mentioned (A) component, (B) one or more components selected from the group consisting of (b-1) monovalent to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. The (A) component in the topical composition is a compound that becomes aromatic when cyclized by lipase, acidic conditions, etc., and is therefore expected to gradually cyclize under the influence of lipase, etc. in the skin by applying the topical composition to the skin, and to emit a long-lasting fragrance. However, the present inventors faced the problem that, in a topical composition containing the (A) component, depending on the composition and skin condition, the fragrance components generated by the cyclization of hydroxy fatty acids, etc., are weak in fragrance, and the fragrance of a fragrance product is insufficient. In order to solve this problem, the inventors investigated many blending components and found that the above-mentioned (B) component has a remarkable effect.

[0018] As the above-mentioned (b-1) component, (b-1-1) monohydric alcohols having 2 carbon atoms, (b-1-2) monohydric or dihydric alcohols having 3 carbon atoms, (b-1-3) trihydric alcohols having 3 carbon atoms, and (b-1-4) monohydric to hexahydric alcohols having 4 to 6 carbon atoms are preferred.

[0019] As the (b-1-1) monohydric alcohol having 2 carbon atoms, ethanol is preferable, as the (b-1-2) monohydric or dihydric alcohol having 3 carbon atoms, propylene glycol (PG) and 1,3-propanediol are preferable, as the (b-1-3) trihydric alcohol having 3 carbon atoms, glycerin is preferable, and as the (b-1-4) monohydric to hexahydric alcohol having 4 to 6 carbon atoms, butanol, 1,3-butylene glycol, 2,3-butylene glycol, pentyl alcohol, pentanediol, hexanol, hexanediol, dipropylene glycol, diglycerin and sorbitol are preferable, 1,3-butylene glycol, 2,3-butylene glycol, pentanediol, hexanediol and dipropylene glycol are more preferable, and 1,3-butylene glycol and dipropylene glycol are even more preferable.

[0020] As the (b-1) component, the (b-1-1) monohydric alcohol having 2 carbon atoms, the (b-1-3) trihydric alcohol having 3 carbon atoms, and the (b-1-4) monohydric to hexahydric alcohol having 4 to 6 carbon atoms are preferred, and among these, ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol are more preferred.

[0021] When the topical composition of the present invention contains the above-mentioned (b-1) component as the (B) component, the content of the (b-1) component in the topical composition of the present invention is 0.00001% by weight to 70% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.00005% by weight to 60% by weight, more preferably 0.0001% by weight to 40% by weight, even more preferably 0.0005% by weight to 20% by weight, and particularly preferably 0.001% by weight to 15% by weight. Note that two or more compounds may be used in combination as the (b-1) component, and in that case, the total amount may be within the above numerical range.

[0022] When the topical composition of the present invention contains the above-mentioned (b-1) component as the (B) component, the ratio of the content (by weight) of the (b-1) component to the (A) component (the value obtained by dividing the content (by weight) of the (b-1) component by the content (by weight) of the (A) component) is preferably 5 to 2,500, more preferably 25 to 1,500, even more preferably 50 to 500, and even more preferably 100 to 300.

[0023] Examples of the amphiphilic ester (b-2) include bisethoxydiglycol cyclohexanedicarboxylate, methylpentanediol dineopentanoate, diethylpentanediol dineopentanoate, diethylhexyl sebacate, bis(polyoxyalkylene alkyl ether) dicarboxylate, polyglyceryl-10 (eicosanediacid / tetradecanedioic acid), diethoxyethyl succinate, etc. Among these, bisethoxydiglycol cyclohexanedicarboxylate is preferred from the viewpoint of the above effects.

[0024] When the topical composition of the present invention contains the above-mentioned (b-2) component as the (B) component, the content of the (b-2) component in the topical composition of the present invention is 0.0001% by weight to 30% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.0005% by weight to 25% by weight, more preferably 0.001% by weight to 20% by weight, even more preferably 0.01% by weight to 20% by weight, and particularly preferably 0.1% by weight to 15% by weight. Two or more compounds may be used in combination as the (b-2) component, and in that case, the total amount may be within the above numerical range.

[0025] When the topical composition of the present invention contains the above-mentioned (b-2) component as the (B) component, the ratio of the content (by weight) of the (b-2) component to the (A) component (the value obtained by dividing the content (by weight) of the (b-2) component by the content (by weight) of the (A) component) is preferably 0.5 to 500, more preferably 5 to 300, and even more preferably 10 to 100.

[0026] The above (b-3) phenol derivative refers to a compound containing a phenol ring in the molecule, and the phenol ring in the molecule may have a substituent. Examples of the phenol derivative include phenoxyethanol, isopropylmethylphenol, salicylic acid, phenol, cresol, chlorocresol, xylenol, chloroxylenol, resorcin, orthophenylphenol, etc. Among these, phenoxyethanol and isopropylmethylphenol are preferred, and phenoxyethanol is more preferred.

[0027] When the topical composition of the present invention contains the above-mentioned (b-3) component as the (B) component, the content of the (b-3) component in the topical composition of the present invention is 0.0001% by weight to 10% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.0005% by weight to 8% by weight, more preferably 0.001% by weight to 6% by weight, even more preferably 0.01% by weight to 5% by weight, and particularly preferably 0.05% by weight to 2% by weight. Two or more compounds may be used in combination as the (b-3) component, and in that case, the total amount may be within the above numerical range.

[0028] When the topical composition of the present invention contains the above-mentioned (b-3) component as the (B) component, the ratio of the content (by weight) of the (b-3) component to the (A) component (the value obtained by dividing the content (by weight) of the (b-3) component by the content (by weight) of the (A) component) is preferably 0.1 to 100, more preferably 0.5 to 50, and even more preferably 1 to 25.

[0029] The above (b-4) cationic polymer includes, for example, cationic cellulose derivatives, diallyldimethylammonium chloride-acrylamide polymers, dimethylallylammonium chloride-acrylic acid copolymers, etc., and specifically includes polyquaternium-7, polyquaternium-10, polyquaternium-22, polyquaternium-39, etc. Among them, polyquaternium-10 is preferred.

[0030] When the topical composition of the present invention contains the above-mentioned (b-4) component as the (B) component, the content of the (b-4) component in the topical composition of the present invention is 0.0001% by weight to 50% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.0005% by weight to 30% by weight, more preferably 0.001% by weight to 20% by weight, even more preferably 0.005% by weight to 15% by weight, particularly preferably 0.01% by weight to 10% by weight, and more particularly preferably 0.1% by weight to 5% by weight. Note that two or more compounds may be used in combination as the (b-4) component, and in that case, the total amount may be within the above numerical range.

[0031] When the topical composition of the present invention contains the above-mentioned (b-4) component as the (B) component, the ratio of the content (by weight) of the (b-4) component to the (A) component (the value obtained by dividing the content (by weight) of the (b-4) component by the content (by weight) of the (A) component) is preferably 0.5 to 500, more preferably 5 to 300, and even more preferably 10 to 100.

[0032] The total content of the (B) component in the topical composition of the present invention is 0.000005% by weight to 80% by weight, and from the viewpoint of the fragrance after application to the skin, it is preferably 0.00001% by weight to 70% by weight, more preferably 0.00005% by weight to 60% by weight, even more preferably 0.0001% by weight to 50% by weight, even more preferably 0.0005% by weight to 40% by weight, particularly preferably 0.001% by weight to 30% by weight, and even more particularly preferably 0.01% by weight to 20% by weight. Note that, as the (B) component, any one of (b-1) to (b-4) or a combination of two or more compounds may be used, and the total amount of these may be within the above numerical range.

[0033] In the topical composition of the present invention, the component (B) is preferably a combination of two or more of the components (b-1) to (b-4), and more preferably three or more of them. When multiple components are selected from the components (b-1) to (b-4), it is preferable to combine components selected from the components (b-1) and (b-3).

[0034] In the topical composition of the present invention, the ratio of the total content (wt%) of component (B) to component (A) (the value obtained by dividing the total content (wt%) of component (B) by the content (wt%) of component (A)) is preferably 10 to 2,500, more preferably 50 to 2,000, and even more preferably 100 to 1,000.

[0035] <(C) component> The topical composition of the present invention preferably contains a fragrance (C) (excluding the component (A)) in addition to the above-mentioned components (A) and (B). The topical composition of the present invention can emit a fragrance for a long time from immediately after use by further containing the component (C). The component (C) is not particularly limited as long as it is used as a component of a skin topical agent in a pharmaceutical product, a quasi-drug product, or a cosmetic. The component (C) may be a natural fragrance or a synthetic fragrance, but it is preferable to use a fragrance containing an essential oil or an oil-soluble component. In addition, a plant-based fragrance that evokes plants is preferable, and among these, a fruit-based fragrance or a floral-based fragrance is more preferable, and a fruit-based fragrance is particularly preferable. Specific examples of the component (C) include γ-decalactone, γ-undecalactone, δ-decalactone, δ-undecalactone, and the like. Among them, γ-decalactone and γ-undecalactone are preferable from the viewpoint of achieving the effects of the invention, and γ-undecalactone is more preferable.

[0036] When component (C) is γ-undecalactone, the content of component (C) in the topical composition of the present invention is preferably 0.0001 to 10 mass%, more preferably 0.001 to 8%, even more preferably 0.01 to 5%, and particularly preferably 0.05 to 2%.

[0037] When the component (C) is γ-undecalactone, the ratio of the component (C) (weight %) to the component (A) (the value obtained by dividing the content (weight %) of the component (C) by the content (weight %) of the component (A)) is preferably 0.0025 to 200,000, more preferably 0.01 to 40,000, even more preferably 0.1 to 500, and particularly preferably 0.1 to 50.

[0038] <Optional ingredients> In addition to the above-mentioned components, the topical composition of the present invention may contain the following optional components as long as the effects of the present invention are not impaired.

[0039] The topical composition of the present invention may contain, as optional components, for example, anti-inflammatory agents, refreshing agents, germicides, preservatives, vitamins, organic acids, moisturizing components, scrubbing agents, UV-absorbing components, UV-scattering components, astringent components, peptides or derivatives thereof, amino acids or derivatives thereof, cleansing components, keratin softening components, cell activating components, anti-aging components, blood circulation promoting components, whitening components, powders, etc. In the topical composition of the present invention, each of these components may be used alone or in combination of two or more types.

[0040] Examples of anti-inflammatory agents include allantoin and its derivatives, glycyrrhetinic acid and its derivatives, glycyrrhizic acid and its derivatives, salicylic acid derivatives, aminocaproic acid, azulene and its derivatives, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone, and salts thereof.Specific examples include allantoin, allantoin chlorhydroxyaluminum, allantoin dihydroxyaluminum, glycyrrhetinic acid, glycyrrhetinic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilon aminocaproic acid, azulene, guaiazulene, and salts thereof.Note that the term "derivative" refers to the ester, ether, alkylation product, glycoside, etc. of the compound described.Note that the term "salt" refers to, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid, or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, etc.The same applies to the optional components described below.

[0041] Examples of the cooling agents include terpenes such as camphor, 1-menthol, borneol, geraniol, cineole, anethole, limonene, and eugenol (which may be in any of the d-, l-, or dl-forms); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine.

[0042] Examples of the disinfectants include chlorhexidine, acrinol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, alkyldiaminoglycine hydrochloride, piroctoolamine, and miconazole.

[0043] Examples of the preservatives include methyl benzoate, ethyl benzoate, propyl benzoate, sodium benzoate, chlorphenesin, and caprylhydroxamic acid.

[0044] The vitamins may be either water-soluble or oil-soluble, and examples thereof include vitamin B6 such as pyridoxine, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and salts thereof (e.g., pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxamine hydrochloride); pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, pantothenyl ethyl ether, and salts thereof; nicotinic acid, nicotinic nicotinic acids such as dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, nicotinamide, and salts thereof; gamma-oryzanol, thiamine, dibenzoylthiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine Vitamin B1 such as nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine diphosphate hydrochloride, and thiamine triphosphate monophosphate; Vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, and salts thereof; Vitamin B3 such as biotin, biocytin, and salts thereof. tins; folates such as folic acid, pteroylglutamic acid, and their salts; vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, and their salts; water-soluble vitamin C such as ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid-2-glucoside, 3-O-ethyl ascorbic acid, and their salts (e.g., sodium ascorbate, sodium ascorbyl phosphate, magnesium ascorbyl phosphate);Vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; oil-soluble vitamin C such as ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, and ascorbyl tetra-2-hexyldecanoate; vitamin D such as ergocalciferol and cholecalciferol; vitamin K such as phylloquinone and farnoquinone; and vitamin-like factors such as ferulic acid.

[0045] Examples of the organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, and salts thereof. Examples of the salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, and phosphoric acid, salts of organic acids such as maleic acid and methanesulfonic acid, salts of alkali metals such as sodium and potassium, alkaline earth metal salts, and ammonium salts.

[0046] Examples of the moisturizing components include diglycerin trehalose; polymeric compounds such as sodium hyaluronate, heparinoids, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and perilla extract.

[0047] Examples of the scrubbing agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, seawater dried granules, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder, hazel shell powder, polyethylene powder, and anhydrous silicic acid.

[0048] Examples of the ultraviolet absorbing component include cinnamic acid-based ultraviolet absorbers such as di-paramethoxycinnamate mono-2-ethylhexanoate glyceryl; paramethoxycinnamate 2-ethylhexyl; dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl; 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol]; 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, diethylhexylbutamidotriazon, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, diethylhexylbutamidotriazon ... benzalmalonate derivative ultraviolet absorbers such as dimethicodiethyl benzalmalonate; octocrylene ultraviolet absorbers such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; imidazole sulfonic acid derivative ultraviolet absorbers such as 2-phenylbenzimidazole-5-sulfonic acid and disodium phenyldibenzimidazole tetrasulfonate; and benzophenone derivative ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, and tetrahydroxybenzophenone.

[0049] Examples of the ultraviolet ray scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and silicic anhydride; these inorganic compounds are coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica, and talc; or are composited with resin powders such as polyamide, polyethylene, polyester, polystyrene, and nylon; and further treated with silicone oil, aluminum salt of a fatty acid, or the like.

[0050] Examples of the astringent ingredient include zinc sulfate, aluminum chloride, zinc sulfocarbonate, tannic acid, and the like.

[0051] Examples of the above peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.), and the like.

[0052] Examples of the above amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, and the like.

[0053] Examples of the cleaning components include soaps selected from alkali metal salts, alkanolamide salts, and amino acid salts, such as potassium laurate, potassium myristate, potassium palmitate, and potassium stearate; amino acid surfactants, such as sodium cocoyl glutamate and sodium cocoyl methyl taurate; ether sulfate salts, such as sodium laureth sulfate; ether carboxylates, such as sodium lauryl ether acetate; sulfosuccinate salts, such as sodium alkyl sulfosuccinate; fatty acid alkanolamides, such as coconut oil fatty acid monoethanolamide and coconut oil fatty acid diethanolamide; monoalkyl phosphate salts, such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate; betaine-type amphoteric surfactants, such as coconut oil fatty acid amidopropyl dimethylaminoacetate betaine, lauryl dimethylaminoacetate betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine, and sodium lauroyl amidoethyl hydroxyethyl carboxymethyl betaine hydroxypropyl phosphate; and amino acid amphoteric surfactants, such as sodium lauryl aminopropionate.

[0054] Examples of the keratin softening ingredient include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, glycolic acid, and sulfur.

[0055] Examples of the cell activation components include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids, etc.; α-hydroxy acids such as glycolic acid, lactic acid, etc.; tannins, flavonoids, saponin, photosensitizer No. 301, etc.

[0056] Examples of the anti-aging ingredients include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

[0057] Examples of the blood circulation promoting component include components derived from plants (e.g., ginseng, angelica, arnica, ginkgo, fennel, Japanese oak, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, ginger, European hawthorn, European juniper, Cnidium rhizome, Swertia japonica, thyme, clove, tangerine peel, chili pepper, angelica tree, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, ryokucha, rosemary, rose hip, tangerine peel, angelica tree, spruce, peach, apricot, walnut, corn, etc.); acetylcholine, ichthammol, cantharides tincture, gamma oryzanol, cepharanthine, tolazoline, tocopherol nicotinate, glucosyl hesperidin, etc.).

[0058] Examples of the whitening ingredient include tocopherol, tranexamic acid, nicotinamide, ascorbic acid or a salt thereof, and an ascorbic acid derivative or a salt thereof.

[0059] Examples of the powder components include aluminum starch octenylsuccinate, talc, corn starch, magnesium hydroxide, anhydrous silicic acid, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium oxide, nylon powder, charcoal, kaolin, and calamine.

[0060] <ph> The pH of the composition for external use of the present invention is usually 3.0 or more and 11.0 or less, preferably 3.0 or more, 4.5 or more, 5.0 or more, and preferably 11.0 or less, 10.0 or less, 9.0 or less, 8.0 or less, 7.0 or less. The pH of the composition for external use of the present invention is preferably 3.0 or more and 10.0 or less, 3.0 or more and 9.0 or less, 3.0 or more and 8.0 or less, 3.0 or more and 7.0 or less, 4.5 or more and 11.0 or less, 4.5 or more and 10.0 or less, 4.5 or more and 9.0 or less, 4.5 or more and 8.0 or less, 4.5 or more and 7.0 or less, 5.0 or more and 11.0 or less, 5.0 or more and 10.0 or less, 5.0 or more and 9.0 or less, 5.0 or more and 8.0 or less, 5.0 or more and 7.0 or less. This pH can be adjusted, for example, by using a pH adjuster described later.

[0061] <Method of manufacturing the topical composition> The method for producing the topical composition of the present invention is not particularly limited, and the composition can be produced by a conventional method by appropriately selecting and mixing the essential components (A) and (B), the component (C) that is mixed as necessary, and other components (the above-mentioned optional components, the base or carrier, additives, etc. described below). The topical composition of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.

[0062] <Uses of topical compositions> The topical composition of the present invention is used in products that are applied directly to the skin by coating, spraying, or other methods, or in products that are applied to articles that come into direct contact with the skin, and can be used in cosmetics for the purpose of masking various odors generated on the skin or imparting a pleasant fragrance. The topical composition of the present invention used for such purposes can be suitably used as, for example, skin care products such as lotions, milky lotions, and beauty essences, cleansing agents such as body soaps and face washes, hair care agents such as shampoos, treatments, and dry shampoos, cleansing agents, deodorants, antiperspirants, ointments, sticks, liquids, suspensions, emulsions (milky lotions and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, granules, etc.

[0063] <Preparation> The topical composition of the present invention can be prepared in various formulations by mixing the essential components and the other components described above with a base or carrier commonly used in cosmetics, medicines, and quasi-drugs, and, if necessary, with additives described below, according to a conventional method, and emulsifying or solubilizing as necessary. The formulation form of the topical composition of the present invention is not particularly limited, and examples thereof include ointments, liquids, suspensions, emulsions (milks and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, and granules. Among these, liquid to semi-solid formulations are preferred, and are particularly useful when applied to solutions, lotions, ointments, gels, and emulsions. These formulations can be prepared according to conventional methods, such as the methods described in the General Provisions of Preparations in the 18th Revised Japanese Pharmacopoeia.

[0064] Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; silicone oils such as methyl polysiloxane, highly polymerized methyl polysiloxane, cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; oils and fats such as coconut oil, jojoba oil, olive oil, rice bran oil, and shea butter; waxes such as beeswax, candelilla wax, sunflower wax, and lanolin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, and cholesterol; ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, and the like. Examples of the polysaccharides include dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether; and water.

[0065] The composition for external use of the present invention may contain water as a base, and the amount of water in the preparation is preferably 1 to 99% by mass, more preferably 5 to 85% by mass, and even more preferably 10 to 80% by mass. From the viewpoint of achieving the effects of the present invention, the amount of water may be 30 to 80% by mass, 40 to 75% by mass, or 50 to 70% by mass.

[0066] When the composition for external use of the present invention contains a base or carrier other than water, the base or carrier is preferably, for example, higher alcohol, hydrocarbon, oil, ester, silicone oil, wax, vinyl polymer, and more preferably higher alcohol, ester oil, silicone oil, vinyl polymer.Of these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl triethylhexanoate, dimethicone, cyclomethicone, polyether modified silicone, polyglycerin modified silicone, carboxyvinyl polymer are more preferred.

[0067] The bases or carriers described above may be used alone or in combination of two or more. The amounts of the bases or carriers used are appropriately selected from the ranges known to those skilled in the art.

[0068] <Additives> The topical composition of the present invention may contain known additives added to cosmetics, pharmaceuticals, and quasi-drugs, such as surfactants, stabilizers, antioxidants, colorants, pearlescent agents, dispersants, chelating agents, pH adjusters, thickeners, irritation reducers, etc., within the scope of not impairing the effects of the present invention. These additives may be used alone or in combination of two or more.

[0069] The surfactant may be any of nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, and the like, and examples thereof include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene monolaurate, Examples of suitable surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococoate glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; silicone surfactants such as polyoxyethylene-methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone. Of these, nonionic surfactants are preferred, and hydrogenated castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyalkylene alkyl ethers are more preferred.

[0070] Examples of the stabilizer include sucrose fatty acid esters, hydrogenated castor oil isostearate, hydrogenated castor oil isostearate, mannitol, cyclodextrin, sodium stearoyl methyl taurate, and the like.

[0071] Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine ​​hydrochloride, sodium pyrosulfite, polyphenols, and fullerene.

[0072] Examples of the colorant include inorganic pigments and natural dyes.

[0073] Examples of the pearly luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

[0074] Examples of the dispersing agent include di(phytosteryl-2-octyldodecyl) N-lauroyl-L-glutamate, di(phytosteryl-behenyl-2-octyldodecyl) N-lauroyl-L-glutamate, diethylhexyl sodium sulfosuccinate, polyglyceryl polyricinoleate, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), lecithin, acrylic acid / alkyl methacrylate copolymer, (acrylates / ethylhexyl acrylate / dimethicone methacrylate) copolymer, and the like.

[0075] Examples of the chelating agent include EDTA disodium salt, EDTA calcium disodium salt, and the like.

[0076] Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), etc. Among these, inorganic bases and / or organic bases are preferred, and potassium hydroxide and triethanolamine are more preferred.

[0077] Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, (acrylates / alkyl acrylate (C10-30)) crosspolymer, (hydroxyethyl acrylate / Na acryloyldimethyl taurate) copolymer, and (ammonium acryloyldimethyl taurate / vinylpyrrolidone) copolymer; cellulose thickeners such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose; guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, acrylate / alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, and sodium hyaluronate. Of these, vinyl-based thickeners and cellulose-based thickeners are preferred, and carboxyvinyl polymers, (acrylates / C10-30 alkyl acrylate) crosspolymers, polyvinylpyrrolidone, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose are more preferred.

[0078] Examples of the irritation reducer include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, and the like.

[0079] [Method for enhancing the fragrance of a composition for external use] The present invention also includes a method for enhancing the fragrance of an external use composition after application to the skin, which comprises blending in an external use composition containing (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and having a hydroxy group at position 4 or 5 (also referred to as "component (A)"), (B) one or more components (also referred to as "component (B)") selected from the group consisting of (b-1) mono- to hexavalent alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers.

[0080] Since component (A) in the topical composition is a compound that becomes aromatic when cyclized by lipase, acidic conditions, etc., it is expected that by applying the topical composition to the skin, cyclization will proceed gradually due to the influence of lipase in the skin, and the fragrance will be emitted for a long period of time. However, as mentioned above, the present inventor faced the problem that the topical composition has a weak fragrance depending on the composition, and is not effective enough as a fragrance product. As a result of examining many ingredients to solve this problem, the inventor found that component (B) has a remarkable effect, and completed the method of the present invention.

[0081] The method of the present invention is to further blend component (B) into the topical composition containing component (A) to obtain the topical composition of the present invention described above, which has the effect of enabling the lactone fragrance to be fully released when applied to the skin, and further enabling the fragrance to be maintained on the skin for a long period of time. Therefore, the explanation of each component that can be used in the method of the present invention, such as component (A), component (B), optional component (C), and other components, can be directly applied to the explanation in the section on the topical composition of the present invention described above. EXAMPLES

[0082] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0083] The compositions for external use of Reference Example, Comparative Example 1, and Examples 1 to 8 were prepared according to the usual method, according to the formulations shown in Table 1 below. 900 μl of each solution of the composition for external use was soaked in cotton, placed in a 100 ml glass screw-top bottle, capped, and left to stand for 5 minutes, after which 1800 μl of artificial sweat (acidic) JIS L0848:2004 was poured over it. The cap of the screw-top bottle was closed, and the bottle was left to stand for one week at room temperature under indoor light, after which the scent of each test product was evaluated based on the average of the scores given by three expert evaluation panelists. The evaluation criteria (scores) were based on the strength of the lactone odor when Comparative Example 1 was taken as 0, and were evaluated on a 6-point scale as follows:

[0084] (Score) 5: Compared to Comparative Example 1, the lactone odor is very strong. 4: Compared to Comparative Example 1, the lactone odor is stronger. 3: Compared to Comparative Example 1, lactone odor is felt 2: The lactone odor is slightly stronger than in Comparative Example 1. 1: The lactone odor is slightly stronger than in Comparative Example 1. 0: Lactone odor equivalent to that of Comparative Example 1

[0085] [Table 1]

[0086] As shown in Table 1, the reference example, in which artificial sweat was not added to the topical composition containing sodium 4-hydroxyundecanoate, was rated as having a stronger lactone odor (score 5) than comparison example 1, in which artificial sweat was added.

[0087] In Examples 1 to 8, the results showed that the fragrance was stronger than that of Comparative Example 1 by blending ethanol, glycerin, BG (1,3-butylene glycol), DPG (dipropylene glycol), phenoxyethanol, menthol, bisethoxydiglycol cyclohexanedicarboxylate, polyquaternium-10, and IPMP (isopropylmethylphenol) into the topical composition containing sodium 4-hydroxyundecanoate. In particular, the topical composition blended with glycerin, BG (1,3-butylene glycol), and phenoxyethanol was evaluated as having a much stronger lactone odor than that of Comparative Example 1 after storage at RT (room temperature) for one week. In addition, sufficient effects were obtained by blending ethanol and bisethoxydiglycol cyclohexanedicarboxylate, and excellent effects were obtained by blending DPG (dipropylene glycol), polyquaternium-10, and IPMP. The effects such as fragrance obtained by the topical compositions of these Examples were more remarkable than those of conventional fragrance ingredients. In addition, in a formulation (Example 1') in which 0.1% γ-undecalactone was added to the composition of Example 1 and the amount was adjusted by the water content, the amount of fragrance derived from sodium 4-hydroxyundecanoate increased when the amount of fragrance from γ-undecalactone decreased, demonstrating that the fragrance effect can be maintained for a long time. Furthermore, all of the compositions of the examples were formulations that had a long-lasting fragrance and were also excellent in usability.

[0088] Examples of formulations for the topical composition of the present invention are given below.

[0089] <Formulation Example 1: Body Cream (O / W) 1> Sodium 4-hydroxyundecanoate 0.5% by weight γ-Undecalactone 0.1% by weight Ethanol 1% by weight Glycerin 6% by weight 1,3-butylene glycol 8% by weight Diethoxyethyl succinate 0.5% by weight Carboxyvinyl polymer 0.05% by weight Xanthan gum 0.1% by weight Polyoxyethylene hydrogenated castor oil (60E.O.) 0.5% by weight PPG-6 decyltetradecene-30 0.4% by weight Sorbitan stearate 1.0% by weight Caprylic / capric triglyceride 3% by weight Sugar squalane 10% by weight Liquid paraffin 2% by weight Dimethicone 1% by weight Macadamia nut oil fatty acid phytosteryl 1% by weight Beeswax 0.5% by weight Behenyl alcohol 1% by weight Stearyl alcohol 1% by weight Myristic acid 0.18% by weight Stearic acid 2.82% by weight Retinol palmitate 0.1% by weight Trehalose 1% by weight Methylparaben 0.15% by weight Water remaining Total 100% by weight

[0090] <Formulation Example 2: Body Cream (O / W) 2> Sodium 4-hydroxyundecanoate 0.1% by weight Propylene glycol 3% by weight 1,3-propanediol 3% by weight Pentanediol 3% by weight Dipropylene glycol 1% by weight Diglycerin 1% by weight Cyclohexanedicarboxylic acid bisethoxydiglycol 1% by weight Phenoxyethanol 0.3% by weight Acrylic acid / alkyl methacrylate copolymer 0.1% by weight Hydroxyethyl cellulose 0.05% by weight Sodium dilauroyl glutamate lysine 0.1% by weight Glyceryl stearate 0.8% by weight Polyoxyethylene sorbitan isostearate (20E.O.) 1.2% by weight Cetyl ethylhexanoate 2% by weight Jojoba oil 3% by weight Vaseline 1% by weight N-Lauroyl-L-Glutamine Sanshiji (Phytosteryl 2 -Octyldodecyl) 0.5% by weight Shea butter 0.7% by weight Cetanol 0.8% by weight Glycyrrhizic acid 2K 0.05% by weight Triethanolamine 0.05% by weight Sodium benzoate 0.2% by weight Water remaining Total 100% by weight

[0091] <Formulation Example 3: Body Cream (O / W) 3> Sodium 4-hydroxydecanoate 0.8% by weight γ-Decalactone 0.05% by weight Glycerin 5% by weight 2,3-butylene glycol 7% by weight Hexanediol 1% by weight Sorbitol 1% by weight Polyglyceryl-10 (eicosane diacid / tetradecanedioic acid) 1% by weight Isopropylmethylphenol 0.1% by weight Carboxyvinyl polymer 0.2% by weight Xanthan gum 0.2% by weight Hydrogenated lecithin 0.2% by weight Sorbitan stearate 0.5% by weight Ceteth-20 1% by weight Olive oil 8% by weight Dimethicone 0.4% by weight Dilinoleic acid di(phytosteryl / isostearyl / cetyl / Stearyl / Behenyl) 1% by weight Shea butter 0.2% by weight Stearyl alcohol 0.5% by weight Glycyrrhizic acid 2K 0.1% by weight Ascorbic acid glucoside 2% by weight Methyl gluceth-10 0.5% by weight Arginine 0.01% by weight Citric acid 0.05% by weight Sodium citrate 0.07% by weight Chlorphenesin 0.1% by weight Water remaining Total 100% by weight

[0092] <Formulation example 4: Body lotion> Sodium 4-hydroxyundecanoate 2% by weight 1,3-propanediol 2% by weight 1,3-butylene glycol 3% by weight Sorbitol 2% by weight Polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) 0.5% by weight Phenoxyethanol 0.2% by weight Xanthan gum 0.5% by weight Sodium dilauroyl glutamate lysine 1% by weight Cetyl ethylhexanoate 8% by weight Sugar squalane 8% by weight Cetearyl alcohol 3% by weight Water remaining Total 100% by weight

[0093] <Formulation example 5: Body lotion> Sodium 5-hydroxydecanoate 1% by weight Glycerin 5% by weight 1,3-butylene glycol 10% by weight Hexanediol 2% by weight Hydroxyethylcellulose dimethyldiallylammonium chloride 0.1% by weight Acrylic acid / alkyl methacrylate copolymer 0.3% by weight Sorbitan stearate 0.3% by weight Polyoxyethylene sorbitan isostearate (20E.O.) 0.5% by weight Caprylic / capric triglyceride 8% by weight Liquid paraffin 3% by weight N-Lauroyl-L-Glutamine Sanshiji (Phytosteryl 2 -Octyldodecyl) 1% by weight Behenyl alcohol 0.2% by weight Stearyl alcohol 2% by weight Trehalose 0.5% by weight Sodium hydroxide 0.01% by weight Methylparaben 0.1% by weight Ethylparaben 0.1% by weight Water remaining Total 100% by weight

[0094] <Formulation Example 6: Body Sheet 1> Sodium 4-hydroxyundecanoate 1.5% by weight Ethanol 5% by weight 1,3-butylene glycol 8% by weight Pentanediol 2% by weight Hexanediol 1% by weight Diglycerin 3% by weight Dimethyldiallylammonium chloride-acrylamide copolymer 0.1% by weight Xanthan gum 0.01% by weight Arginine 0.2% by weight Sodium benzoate 0.1% by weight Water remaining Total 100% by weight

[0095] <Formulation Example 7: Body Sheet 2> Sodium 5-hydroxyundecanoate 1% by weight Propylene glycol 6% by weight Glycerin 9% by weight Dipropylene glycol 9% by weight Sorbitol 3% by weight Cyclohexanedicarboxylic acid bisethoxydiglycol 3% by weight Isopropylmethylphenol 0.05% by weight O-[2-hydroxy-3-(trimethylammonio) chloride Propyl]hydroxyethyl cellulose 0.3% by weight Hydroxyethyl cellulose 0.1% by weight Sodium benzoate 0.05% by weight Water remaining Total 100% by weight

[0096] <Formulation example 8: Hair mist> Sodium 4-hydroxyundecanoate 2.5% by weight Ethanol 20% by weight Sorbitol 5% by weight Cyclohexanedicarboxylic acid bisethoxydiglycol 5% by weight Dimethyldiallylammonium chloride-acrylamide copolymer 0.2% by weight Acrylamide, acrylic acid, dimethyl diallyl chloride Ammonium copolymer liquid 0.2% by weight Hydrogenated lecithin 0.05% by weight Chlorphenesin 0.05% by weight Water remaining Total 100% by weight

[0097] <Formulation example 9: Gel for delicate areas> Sodium 4-hydroxydecanoate 1% by weight Diethoxyethyl succinate 1% by weight Polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) 1.5% by weight Phenoxyethanol 0.1% by weight Isopropylmethylphenol 0.05% by weight (Acryloyldimethyltaurate ammonium / VP) copolymer 0.1% by weight (Acrylates / Stearic Acid 20) Copolymer 0.05% by weight Sodium dilauroyl glutamate lysine 0.05% by weight Hydrogenated lecithin 0.1% by weight Glyceryl stearate 0.05% by weight Jojoba oil 0.1% by weight Glycyrrhizic acid 2K 0.5% by weight Methyl gluceth-10 1% by weight Trehalose 2% by weight Sodium hydroxide 0.1% by weight Chlorphenesin 0.2% by weight Water remaining Total 100% by weight

[0098] <Formulation example 10: Mist for delicate areas> Sodium 4-hydroxyundecanoate 1.2% by weight Glycerin 10% by weight 1,3-butylene glycol 5% by weight Diglycerin 5% by weight Phenoxyethanol 0.2% by weight Isopropylmethylphenol 0.1% by weight Hydroxyethyl cellulose 0.2% by weight Sodium dilauroyl glutamate lysine 0.5% by weight Citric acid 0.1% by weight Sodium citrate 0.2% by weight Water remaining Total 100% by weight

[0099] <Formulation Example 11: Fabric Mist> Sodium 4-hydroxyundecanoate 3% by weight Ethanol 70% by weight Water remaining Total 100% by weight

[0100] <Formulation Example 12: Antiperspirant Cream (W / O)> Sodium 4-hydroxydecanoate 0.5% by weight 1,3-butylene glycol 5% by weight Hexanediol 1% by weight Phenoxyethanol 0.3% by weight Isopropylmethylphenol 0.1% by weight Sorbitan stearate 2% by weight Polyoxyethylene sorbitan isostearate (20E.O.) 2% by weight Caprylic / capric triglyceride 10% by weight Cetyl ethylhexanoate 5% by weight Liquid paraffin 10% by weight Dimethicone 20% by weight Macadamia nut oil fatty acid phytosteryl 1% by weight Beeswax 1% by weight Behenyl alcohol 3% by weight Aluminum chlorohydrate 1% by weight Silica 3% by weight Talc 5% by weight Water remaining Total 100% by weight

[0101] <Formulation Example 13: Antiperspirant Gel> Sodium 5-hydroxydecanoate 0.3% by weight Ethanol 10% by weight Pentanediol 1% by weight Diglycerin 5% by weight Isopropylmethylphenol 0.3% by weight Carboxyvinyl polymer 0.5% by weight Xanthan gum 0.3% by weight Polyoxyethylene hydrogenated castor oil (60E.O.) 3% by weight Cetyl ethylhexanoate 1% by weight Sodium hydroxide 0.1% by weight Water remaining Total 100% by weight

[0102] <Formulation example 14: Antiperspirant mist> Sodium 4-hydroxyundecanoate 0.1% by weight Ethanol 60% by weight Glycerin 3% by weight 1,3-butylene glycol 3% by weight Diethoxyethyl succinate 1% by weight Isopropylmethylphenol 0.1% by weight Acrylamide, acrylic acid, dimethyl diallyl chloride Ammonium copolymer liquid 0.1% by weight Hydroxyethyl cellulose 0.1% by weight Aluminum chlorohydrate 1% by weight Silica 10% by weight Water remaining Total 100% by weight

[0103] <Formulation example 15: Sunscreen gel> Sodium 4-hydroxyundecanoate 0.3% by weight Ethanol 5% by weight Glycerin 3% by weight 1,3-butylene glycol 5% by weight Pentanediol 1% by weight Diethoxyethyl succinate 1% by weight Phenoxyethanol 0.3% by weight Acrylamide, acrylic acid, dimethyl diallyl chloride Ammonium copolymer liquid 0.1% by weight Carboxyvinyl polymer 0.8% by weight (Acryloyldimethyltaurate ammonium / VP) copolymer 0.5% by weight Polyoxyethylene hydrogenated castor oil (60E.O.) 1% by weight Sorbitan stearate 1% by weight Caprylic / capric triglyceride 3% by weight Cetyl ethylhexanoate 3% by weight Sugar squalane 2% by weight Dimethicone 5% by weight Ethylhexyl paramethoxycinnamate 9% by weight Polysilicone-15 3% by weight Ethylhexyl triazone 0.5% by weight Diethylamino hydroxybenzoyl hexyl benzoate 1% by weight Bisethylhexyloxyphenol methoxyphenyl triazine 1.5% by weight Cetanol 1% by weight Stearyl alcohol 1% by weight Glycyrrhizic acid 2K 0.1% by weight Triethanolamine 0.5% by weight Water remaining Total 100% by weight

[0104] <Formulation Example 16: Body Powder> Glycerin 1% by weight Polyglyceryl-10 (eicosane diacid / tetradecanedioic acid) 0.3% by weight Phenoxyethanol 0.5% by weight Dimethicone 2% by weight Silica 81.2% by weight Zinc myristate 15% by weight Total 100% by weight

[0105] <Formulation example 17: Body soap> Sodium 4-hydroxyundecanoate 0.1% by weight Propylene glycol 3% by weight Glycerin 1% by weight Dipropylene glycol 1% by weight Phenoxyethanol 0.3% by weight Isopropylmethylphenol 0.1% by weight O-[2-hydroxy-3-(trimethylammonio) chloride Propyl]hydroxyethyl cellulose 0.1% by weight Hydroxyethyl cellulose 0.5% by weight Sodium dilauroyl glutamate lysine 0.1% by weight POE lauryl ether acetate sodium 3% by weight Coconut oil fatty acid aminopropyl betaine 4% by weight Lauric acid 6% by weight Myristic acid 6% by weight K hydroxide 3.4% by weight Methylparaben 0.1% by weight Water remaining Total 100% by weight

[0106] <Formulation example 18: Shampoo> Sodium 5-hydroxydecanoate 0.05% by weight Sodium 5-hydroxyundecanoate 0.1% by weight 1,3-propanediol 1% by weight Glycerin 2% by weight Diglycerin 1% by weight Sorbitol 3% by weight Cyclohexanedicarboxylic acid bisethoxydiglycol 0.5% by weight Phenoxyethanol 0.4% by weight O-[2-hydroxy-3-(trimethylammonio) chloride Propyl]hydroxyethyl cellulose 0.4% by weight Xanthan gum 0.3% by weight Sodium cocoyl glutamate 6% by weight Coconut oil fatty acid aminopropyl betaine 7% by weight Cocamide MEA 1% by weight Decyl glucoside 3% by weight Jojoba oil 0.1% by weight Arginine 0.1% by weight Citric acid 0.3% by weight Sodium citrate 0.1% by weight Sodium benzoate 0.2% by weight Water remaining Total 100% by weight

[0107] <Formulation example 19: Treatment> Sodium 4-hydroxyundecanoate 0.2% by weight Propylene glycol 2% by weight Glycerin 2% by weight Diglycerin 2% by weight Guar hydroxypropyltrimonium chloride 0.5% by weight Hydroxyethyl cellulose 0.2% by weight Behentrimonium chloride 1.5% by weight Cetyl ethylhexanoate 1% by weight Liquid paraffin 3% by weight Dimethicone 2.5% by weight Shea butter 3% by weight Beeswax 0.5% by weight Behenyl alcohol 1% by weight Cetanol 1.5% by weight Stearyl alcohol 1% by weight Sodium benzoate 0.4% by weight Water remaining Total 100% by weight

[0108] <Formulation example 20: After-bath treatment> Sodium 4-hydroxydecanoate 0.7% by weight Ethanol 1% by weight Propylene glycol 0.5% by weight 1,3-butylene glycol 1% by weight Dipropylene glycol 0.5% by weight Cyclohexanedicarboxylic acid bisethoxydiglycol 0.2% by weight Phenoxyethanol 0.2% by weight Guar hydroxypropyltrimonium chloride 0.1% by weight Xanthan gum 0.2% by weight Sodium dilauroyl glutamate lysine 0.8% by weight Laureth-9 2% by weight Steartrimonium chloride 0.2% by weight Phenyl trimethicone 8% by weight Behenyl alcohol 0.5% by weight Water remaining Total 100% by weight

[0109] <Formulation Example 21: Femcare Cleanser> Sodium 4-hydroxyundecanoate 0.5% by weight Glycerin 1% by weight Sorbitol 1% by weight Isopropylmethylphenol 0.05% by weight O-[2-hydroxy-3-(trimethylammonio) chloride Propyl]hydroxyethyl cellulose 0.1% by weight Carboxyvinyl polymer 0.5% by weight Sodium cocoyl glutamate 5% by weight TEA-Cocoylalanine 2% by weight Coconut oil fatty acid aminopropyl betaine 3% by weight Cocamide DEA 0.5% by weight Decyl glucoside 2% by weight Sugar squalane 0.1% by weight Citric acid 0.2% by weight Sodium benzoate 0.1% by weight Water remaining Total 100% by weight [Industrial Applicability]

[0110] According to the present invention, it is possible to provide a composition for external use that maintains its fragrance for a long period of time after application to the skin. Furthermore, according to the composition for external use of the present invention, it is possible to obtain a sufficient fragrance after application to the skin, and further to maintain the fragrance for a long period of time.< / ph>

Claims

1. (A) a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4- or 5-position, and (B) One or more components selected from the group consisting of (b-1) monohydric to hexahydric alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers. A topical composition comprising:

2. The composition for external use according to claim 1, wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof.

3. In the component (B), the component (b-1) is (b-1-1) Monohydric alcohol having 2 carbon atoms (b-1-2) Monohydric or dihydric alcohol having 3 carbon atoms (b-1-3) a trihydric alcohol having 3 carbon atoms, or (b-1-4) containing monohydric to hexahydric alcohols having 4 to 6 carbon atoms; The composition for external use according to claim 1 or 2.

4. The topical composition according to claim 1 or 2, wherein the component (B) comprises one or more components selected from the group consisting of ethanol, glycerin, 1,3-butylene glycol, and dipropylene glycol as the component (b-1), bisethoxydiglycol cyclohexanedicarboxylate as the component (b-2), phenoxyethanol and isopropylmethylphenol as the component (b-3), and polyquaternium-10 as the component (b-4).

5. (A) A composition for external use containing a hydroxy fatty acid or a salt thereof having 10 or more carbon atoms and a hydroxy group at the 4- or 5-position, (B) A method for enhancing the fragrance of the above-mentioned topical composition after application to the skin, characterized by blending one or more components selected from the group consisting of (b-1) monohydric to hexahydric alkyl alcohols, (b-2) amphiphilic esters, (b-3) phenol derivatives, and (b-4) cationic polymers.

6. The method of claim 5 , wherein component (A) comprises 4-hydroxyundecanoic acid or a salt thereof.

7. In the component (B), the component (b-1) is (b-1-1) Monohydric alcohol having 2 carbon atoms (b-1-2) Monohydric or dihydric alcohol having 3 carbon atoms (b-1-3) a trihydric alcohol having 3 carbon atoms, or (b-1-4) a monohydric to hexahydric alcohol having 4 to 6 carbon atoms, The method according to claim 5 or 6.

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