Method for producing emulsion

Abstract

To provide an emulsion of a lipid-soluble substance containing cannabinoids, and a method for easily producing the emulsion.SOLUTION: An emulsion comprises: an oil in which a lipid-soluble substance composed of cannabinoids including at least one selected from CBD, CBG, CBN, CBC, and CBDV is dissolved; and an aqueous dispersion of CNF, and is produced without using a surfactant. The CNF is cellulose isolated by purification through chemical treatment or biosynthesis, with a fiber diameter of 3 to 10 nm.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to emulsions and the like. [Background technology]

[0002] Conventionally, cannabinoid-added preparations have been proposed, such as those disclosed in Patent Document 1. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2023-109849 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, the use of surfactants and stabilizers was necessary, making the formulation complicated.

[0005] It is therefore an object of the present invention to provide an emulsion of fat-soluble substances including cannabinoids in a simple manner, and a method for producing said emulsion. [Means for solving the problem]

[0006] The emulsion of the present invention comprises an oil dissolving a fat-soluble substance composed of cannabinoids including at least one of CBD, CBG, CBN, CBC, and CBDV, and an aqueous dispersion of CNF, and is produced without the use of a surfactant.

[0007] It becomes possible to produce emulsions containing cannabinoids. Compared to oil before emulsification, the emulsion makes it easier for the cannabinoids contained in the fat-soluble substance to penetrate into the body via the aqueous dispersion.

[0008] CNF can adsorb onto the surface of oil droplets, creating a Pickering emulsion effect that generates stable oil droplets. Therefore, an emulsion containing a fat-soluble substance can be easily produced without using a surfactant. In addition, among the CNFs, those that are not used to produce Pickering emulsions do not require stabilizers because their network structure contributes to the stabilization of oil droplets in water. In addition, CNF does not penetrate into the body but remains on the applied surface, but it is so tiny that it cannot be seen with the naked eye.

[0009] It is less volatile than normal water, has high moisturizing properties, and allows the cannabinoids contained in the fat-soluble substances to penetrate the body easily. Therefore, the water-retaining effect of CNF makes it easy to obtain a moisturizing effect while allowing the cannabinoids contained in the fat-soluble substances to penetrate the body.

[0010] Preferably, the CNF is isolated by subjecting cellulose to a purification treatment by chemical treatment or biological synthesis, and has a fiber diameter of 3 to 10 nm.

[0011] Compared to mechanical defibration, this method makes it possible to produce CNFs with smaller fiber diameters and a more uniform network structure.

[0012] More preferably, the concentration of the CNF in the aqueous dispersion is 0.8 to 1.6 percent by weight.

[0013] Also, preferably, the oil is at least one of a vegetable oil and a hydrocarbon oil.

[0014] It is unlikely to have any adverse effects on human skin or other parts of the body when it comes into contact with them.

[0015] More preferably, the emulsion is used as a lotion to be applied to the skin of the human body.

[0016] Compared to oil before emulsification, the amount of oil added to the emulsion can be set to any value. Therefore, when used as a lotion, it is possible to reduce discomfort such as stickiness after application while maintaining the skin-penetrating effect of the cannabinoids contained in the fat-soluble substance.

[0017] The surfactant-free emulsion production method of the present invention includes a dispersion production step of producing an aqueous dispersion of CNF, a dissolving step of dissolving a fat-soluble substance in oil, and an emulsion production step of adding the oil in which the fat-soluble substance has been dissolved in the dissolving step to the aqueous dispersion produced in the dispersion production step, and stirring the mixture.

[0018] Preferably, the method further comprises a water-soluble component addition step of adding a water-soluble component after the emulsion production step.

[0019] By adding the water-soluble component after the formation of the emulsion, the interaction between the water-soluble component and the emulsion can be reduced, making it easier to obtain a stable emulsion. Effect of the Invention

[0020] As described above, according to the present invention, it is possible to simply provide an emulsion of a fat-soluble substance containing cannabinoids, and a method for producing said emulsion. [Brief description of the drawings]

[0021] [Figure 1] FIG. 2 is a diagram showing the configuration of oil and water dispersion in the present embodiment. [Diagram 2] FIG. 2 is a diagram showing the composition of an emulsion according to the present embodiment. [Diagram 3] 1 is a flowchart showing the procedure of a generation method according to the present embodiment. [Figure 4] This is a graph comparing the change over time in the remaining liquid rate due to evaporation between an aqueous dispersion of CNF and water. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0022] Hereinafter, this embodiment will be described with reference to the drawings (see FIGS. 1 to 3). The embodiments are not limited to the following embodiments. In principle, the contents described in one embodiment are also applicable to other embodiments. The embodiments and modifications can be combined as appropriate.

[0023] In addition, in Figs. 1 and 2, in order to explain the substances that make up the emulsion 1, components that are not actually visible (fat-soluble substance 11, CNF 21) are indicated by circles or the like.

[0024] (Emulsion 1) The emulsion 1 in this embodiment is produced by mixing and stirring an oil 13 in which a fat-soluble substance 11 is dissolved and an aqueous dispersion 23 of CNF (cellulose nanofibers) 21.

[0025] (fat-soluble substances 11) The fat-soluble substance 11 is composed of cannabinoids, mainly CBD (cannabidiol). The fat-soluble substance 11 is not limited to CBD, but may be composed of other cannabinoids such as CBG (cannabigerol), CBN (cannabinol), CBC (cannabichromene), and CBDV (cannabidivarin).

[0026] (Oil 13) The oil 13 is composed of at least one of oils that dissolve the fat-soluble substance 11 composed of cannabinoids, for example, vegetable oils such as jojoba oil, argan oil, olive oil, avocado oil, camellia oil, grape seed oil, rice germ oil, pomegranate oil, almond oil, castor oil, broccoli oil, macadamia nut oil, rosehip oil, raspberry oil, and young oil, and hydrocarbon oils such as squalene oil and mineral oil. The concentration of the fat-soluble substance 11 in the oil 13 is preferably adjusted to within 60%.

[0027] (CNF21, water dispersion 23) CNF21 is cellulose that has been isolated through purification processes, either chemically or biologically synthesized. The chemical treatment referred to here includes any one of the TEMPO oxidation method, phosphate esterification method, phosphite esterification method, carboxyl methylation method, xandation method, sulfonation method, enzyme hydrolysis method, acid hydrolysis method, and ionic liquid selective dissolution method. The biological synthesis referred to here includes biological synthesis methods using bacteria and the like. By this purification treatment, the fiber diameter of the CNF21 in this embodiment is desirably adjusted to 3 to 10 nm. The aqueous dispersion 23 contains CNFs 21 in a dispersed state. The concentration of the CNF 21 in the aqueous dispersion 23 is desirably adjusted to 0.8 to 1.6 percent by weight.

[0028] The concentration of CNF21 is desirably adjusted depending on the type of oil, the amount of the oil added, the texture desired for the resulting emulsion 1, and the like. For example, for 60% jojoba oil, a uniform and elastic emulsion 1 can be produced by using an aqueous dispersion 23 with a CNF 21 concentration of 1.6 weight percent. In addition, for 5% jojoba oil, an aqueous dispersion 23 with a CNF 21 concentration of 0.8 weight percent can be used to produce an emulsion 1 with a smooth feel.

[0029] (Procedure for producing emulsion 1) The emulsion 1 is produced by adding oil 13 in which a fat-soluble substance 11 is dissolved to an aqueous dispersion 23 of CNF 21 and mechanically stirring the mixture. That is, the method for producing emulsion 1 includes a dispersion production step S1 for producing an aqueous dispersion 23 of CNF 21, a dissolution step S2 for dissolving fat-soluble substance 11 in oil 13, and an emulsion production step S3 for adding oil 13 having fat-soluble substance 11 dissolved therein to aqueous dispersion 23 and stirring the mixture. The stirring is performed by a stirring device 30 such as a stirrer with stirring blades. In order to advance the fineness of the oil droplets, it is desirable to increase the rotation speed of the stirrer. However, the stirring device 30 may be configured as an ultrasonic device, a high-pressure homogenizer, or a combination of these.

[0030] The addition of the water-soluble component (water-soluble component addition step S4) is desirably carried out after the emulsion 1 is produced. In addition, when adding ionic ingredients such as dipotassium glycylate, vitamin C derivatives, and citric acid as active ingredients other than cannabinoids, the CNF21 structure is preferably one having a pure cellulose structure. The "pure cellulose structure" referred to here is a cellulose structure that has no charge on the side chain and has not been chemically modified, such as carboxymethylated CNF21.

[0031] (Effects of using fat-soluble substances 11 composed of cannabinoids) It becomes possible to produce an emulsion 1 containing cannabinoids. Compared to the oil 13 before emulsification, the amount of oil 13 added to the emulsion 1 can be set to any value. Therefore, when used as a cosmetic, it is possible to reduce discomfort such as stickiness after application while maintaining the skin-penetrating effect of the cannabinoids contained in the fat-soluble substance 11.

[0032] (Effects of using CNF21) CNF21 can adsorb to the surface of oil droplets, creating a Pickering emulsion effect that produces stable oil droplets. Therefore, the emulsion 1 containing the fat-soluble substance 11 can be easily produced without using a surfactant. In addition, the CNF21 that is not used to produce Pickering emulsions does not require a stabilizer because its network structure contributes to the stabilization of oil droplets in water. In addition, CNF21 does not penetrate into the body but remains on the applied surface, but it is so tiny that it cannot be seen with the naked eye.

[0033] (Effect of using aqueous dispersion 23 of CNF21) CNF21 is less likely to volatilize than normal water, has high moisturizing properties, and allows the cannabinoids contained in the fat-soluble substance 11 to penetrate into the body. Therefore, while the cannabinoids contained in the fat-soluble substance 11 penetrate into the body, the water-retaining effect of CNF21 makes it easier to obtain a moisturizing effect (see FIG. 4). FIG. 4 compares the time change in the residual rate of the liquid that is reduced by evaporation due to heating, between an aqueous dispersion 23 of CNF21 and water. Specifically, the residual rate was obtained by filling a 50 mL beaker with about 50 g of water and an aqueous dispersion 23 of CNF21, heating them simultaneously on a hot plate at 85° C., and measuring the weight change. It is shown that the residual rate of the liquid of the aqueous dispersion 23 of CNF21 is higher than that of water.

[0034] (The effect of generating CNF21 through chemical treatment, etc.) Compared to mechanical defibration, this method makes it possible to produce CNF21 with a smaller fiber diameter and a more uniform network structure.

[0035] (The effect of using olive oil as oil 13) It is unlikely to have any adverse effects on human skin or other parts of the body when it comes into contact with them.

[0036] (Effect of performing the water-soluble component addition step S4 after the emulsion production step S3) By adding the water-soluble component after the production of emulsion 1, the interaction between the water-soluble component and emulsion 1 can be reduced, making it easier to obtain a stable emulsion 1.

[0037] Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, substitutions, and modifications can be made without departing from the spirit of the invention. These embodiments and their modifications are within the scope of the invention and its equivalents as described in the claims, as well as the scope and spirit of the invention. [Explanation of symbols]

[0038] 1 emulsion 11 Fat-soluble substances 13. Oil 21 CNF (Cellulose Nanofiber) 23 Aqueous dispersion 30 Stirring device

Claims

1. An oil in which a fat-soluble substance composed of cannabinoids including at least one of CBD, CBG, CBN, CBC, and CBDV is dissolved; and an aqueous dispersion of CNF, the emulsion being produced without the use of a surfactant.

2. The emulsion according to claim 1, wherein the CNF is isolated by subjecting cellulose to a purification treatment by chemical treatment or biological synthesis, and has a fiber diameter of 3 to 10 nm.

3. The emulsion according to claim 2, wherein the concentration of the CNF in the aqueous dispersion is 0.8 to 1.6 weight percent.

4. The emulsion according to claim 1 , wherein the oil is at least one of a vegetable oil and a hydrocarbon oil.

5. 5. The emulsion according to claim 4, which is used as a lotion to be applied to human skin.

6. A dispersion generating step of generating an aqueous dispersion of CNF; A dissolving step of dissolving a fat-soluble substance in oil; A method for producing an emulsion without using a surfactant, comprising: an emulsion production step of adding the oil in which the fat-soluble substance has been dissolved in the dissolving step to the aqueous dispersion produced in the dispersion production step, and stirring the oil.

7. The method of claim 6, further comprising a water-soluble component addition step of adding a water-soluble component after the emulsion formation step.

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