Method for suppressing penetration of topical composition into knitted fabric

Abstract

To provide a topical composition that is difficult to penetrate into clothing, bedding, or the like and is easy to wash off.SOLUTION: When a topical composition contains macrogol, adhesion or penetration of the topical composition into a knitted fabric is suppressed or reduced. In addition, it becomes easier to remove the topical composition that has adhered to or penetrated into the knitted fabric. The macrogol can be one or more types of polyethylene glycols with an average molecular weight in the range of 190 to 1600 and one or more types of polyethylene glycols with an average molecular weight in the range of 2600 to 9300. The topical composition can further contain an oily base. The topical composition is preferably an ointment.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a method for inhibiting the adhesion or penetration of a topical composition into a knitted fabric, and a method for facilitating the removal of a topical composition from a knitted fabric. [Background technology]

[0002] In addition, it is important that topical agents for the skin and mucous membranes are comfortable to use, for example by being less sticky, so that the required amount can be applied to the affected area as many times as necessary to obtain the intended medicinal effect.

[0003] It is difficult for topical agents for skin and mucosa to adhere to moist surfaces such as inflamed or wounded areas, so it is important that they adhere well to the skin and mucosa. On the other hand, if the adhesiveness of the topical composition is good, it will come into contact with clothing, bedding, masks, etc. and will easily adhere to them. When the topical agent adheres to clothing, bedding, masks, etc., it will often soak in and not come off. In particular, delicate areas, feet, shoulders, and buttocks come into strong contact with clothing, and fingers, feet, face, and head are likely to come into contact with bedding, so the amount of application, number of applications, and application area tend to be reduced. Therefore, there is a demand for topical agents that are difficult to soak in even when attached to clothing, bedding, etc., and that are easy to wash off. Summary of the Invention [Problem to be solved by the invention]

[0004] An object of the present invention is to provide a composition for external use which is unlikely to soak into knitted fabric and is easy to wash off. [Means for solving the problem]

[0005] The present inventors conducted extensive research to solve the above problems and discovered that by incorporating macrogol into a topical composition, the topical composition is less likely to soak into knitted fabrics such as clothing, bedding, and masks, and is easier to wash off. The present invention has been completed based on the above findings, and provides the following [1] to

[15] . [1] A method for inhibiting or reducing adhesion or penetration of a topical composition into knitted fabrics by incorporating macrogols into the topical composition. [2] A method for improving the removability of a topical composition from knitted fabrics by incorporating macrogols into the topical composition. [3] The method according to [1] or [2], wherein the macrogol is one or more kinds of polyethylene glycol having an average molecular weight in the range of 190 to 9,300. [4] The method according to [3], wherein the macrogol is one or more kinds of polyethylene glycols having an average molecular weight in the range of 190 to 1,600 and one or more kinds of polyethylene glycols having an average molecular weight in the range of 2,600 to 9,300. [5] The method according to [4], wherein 0.01 to 2 parts by mass of polyethylene glycol having an average molecular weight in the range of 2600 to 9300 is contained per part by mass of polyethylene glycol having an average molecular weight in the range of 190 to 1600. [6] The method according to any one of [1] to [5], wherein the concentration of macrogol is 20% by mass or more based on the total amount of the composition for external use. [7] The method according to any one of [1] to [6], further comprising containing an oily base. [8] The method according to [7], wherein the total amount of the oily base is 30% by mass or less based on the total amount of the macrogol. [9] The method according to any one of [1] to [8], wherein the composition for external use is an ointment.

[10] An agent for suppressing or reducing adhesion or penetration of a topical composition into a knitted fabric, the agent comprising macrogol and being added to the topical composition for use.

[11] An agent for improving the removability of a topical composition from a knitted fabric, which comprises macrogol and is added to the topical composition.

[12] A method for producing a topical composition that is reduced in adhesion to or penetration into knitted fabrics, the method comprising the step of incorporating macrogols into the topical composition.

[13] A method for producing a topical composition having improved removability from knitted fabrics, comprising incorporating macrogols into the topical composition.

[14] An external composition for use on delicate areas, female delicate areas, the vulva, or femcare, comprising macrogol.

[15] A composition for external application containing macrogol for use on skin or mucous membrane sites that come into contact with a knitted fabric containing cotton and / or polyester. Effect of the Invention

[0006] Although topical compositions containing an oily ointment base such as Vaseline have good skin adhesion, when they adhere to clothing, bedding, masks, etc., they tend to soak in and are difficult to wash off, soaking in. In contrast, if macrogol is added to a topical composition, they have good skin adhesion, so they are difficult to adhere to clothing, bedding, masks, etc., and even if they do adhere, they are difficult to soak in and are easy to wash off. This makes it possible to avoid reducing the amount of application, number of applications, or area of ​​application for fear of stains (stains) on clothing, etc., due to the fear that the application of the topical composition will cause stains (stains) on clothing, etc. In addition, the topical composition has good skin adhesion, making it comfortable to use, and is difficult to adhere to or soak into clothing, etc. In addition, the composition is suitable as an external composition to be applied to areas that come into strong contact with clothing, such as delicate areas, the toes, shoulders, buttocks, neck, and back, and areas that are likely to come into contact with bedding, such as the fingers, toes, face, and head. [Brief description of the drawings]

[0007] [Figure 1] This is a photograph of the surface of a cloth made of cotton and polyester after the ointment was imprinted onto the cloth and then dried. The top photo shows the front side (the side where the preparation was applied) and the bottom photo shows the back side. [Diagram 2] The photographs show the surface of a cloth (coated surface) after an ointment or cream has been applied to a cotton and polyester cloth, the cloth has been dried, and the cloth has been washed with water containing detergent. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] The present invention will be described in detail below. (1) Uses of Macrogol The present invention provides a method for inhibiting or reducing adhesion or penetration (staining) of an external composition into a knitted fabric by containing (or causing) macrogols in the external composition. In other words, the present invention provides a method for inhibiting or reducing adhesion or penetration of an external composition into a knitted fabric by containing (or causing) macrogols in the external composition. "Adhesion" refers to a state in which an external composition is attached to the surface of a knitted fabric. In addition, in the present invention, "staining (staining)", "stained" or "stained" refers to a state in which an external composition penetrates into the inside of a knitted fabric and the color of the knitted fabric appears to change. "Adhesion" refers to the ease of adhesion, and "staining" refers to the ease of penetration into a knitted fabric. The present invention also provides a method for improving the removability of a topical composition from a knitted fabric by incorporating (or by incorporating) macrogols into the topical composition, particularly a method for improving the removability of a topical composition that has adhered to or soaked into the knitted fabric. "Removability" refers to the ease of removal. "Removal" refers to removal by washing with water. Washing with water includes the use of water containing additives such as surfactants. In the present invention, examples of knitted fabrics include clothing, bedding, masks, etc. The knitted fabrics include fabrics and knitted fabrics.

[0009] In this way, the inclusion of macrogols inhibits the topical composition from adhering to or penetrating into the knitted fabric, and even if the topical composition does adhere to or penetrate into the knitted fabric, it is easy to remove. Thus, the present invention provides an agent that contains macrogols and is used by adding to a topical composition to inhibit or reduce adhesion or penetration (stains) of a topical composition into a knitted fabric. In other words, the present invention provides an agent that contains macrogols and inhibits or reduces the adhesion or penetration of a topical composition into a knitted fabric. The present invention also provides an agent that contains macrogols and is used by adding to a topical composition to improve the removability of a topical composition from a knitted fabric, particularly an agent that improves the removability of a topical composition that has adhered to or penetrated into a knitted fabric.

[0010] The present invention also provides a method for producing an external composition for reduced adhesion or penetration into knitted fabrics by including macrogols in the external composition. The present invention also provides a method for producing an external composition for improved removability from knitted fabrics by including macrogols in the external composition.

[0011] As shown in the Examples section, topical compositions containing macrogol are less likely to penetrate into knitted fabrics when imprinted, compared with topical compositions containing oily ointment bases such as petrolatum, gelling hydrocarbons, microcrystalline wax, etc. Even if the composition adheres to or penetrates into knitted fabrics, it can be easily removed by rinsing with water. Delicate areas (particularly, women's delicate areas) are areas that are always in contact with underwear and are strongly pressed against the underwear. In addition, because they are prone to becoming humid, the environment is one in which the topical composition flows and easily adheres to or soaks into the underwear. Therefore, topical compositions containing macrogol can be suitably used as topical compositions for delicate areas (particularly, women's delicate areas, especially the vulva) or femcare. In addition, because delicate areas (particularly, women's delicate areas, especially the vulva) are more humid than dry skin areas, topical compositions are less likely to adhere to them. However, topical compositions containing macrogol have good skin adhesion, which prevents the composition from adhering to underwear and further prevents the composition from soaking into the underwear. Therefore, they can be suitably used as topical compositions for delicate areas (particularly, women's delicate areas, especially the vulva) or femcare.

[0012] In addition, since it has been confirmed in the Examples section that the topical composition containing macrogol does not easily penetrate into fabrics made of cotton and polyester, and is easy to remove after adhesion and slight penetration, the topical composition containing macrogol is suitable for use on skin or mucous membranes that come into contact with a knitted fabric containing cotton and / or polyester, or on skin or mucous membranes that wear a knitted fabric containing cotton and / or polyester. The knitted fabric containing cotton and / or polyester may be a knitted fabric made of cotton and / or polyester.

[0013] (2) Macrogol Macrogol is a polyethylene glycol that meets the standards set forth in the Japanese Pharmacopoeia or Pharmaceutical Excipients Standards. There are different average molecular weights, including Macrogol 200, Macrogol 300, Macrogol 600, Macrogol 1000, and Macrogol 1540 listed in the Pharmaceutical Excipients Standards 2018, and Macrogol 400, Macrogol 1500, Macrogol 4000, Macrogol 6000, and Macrogol 20000 listed in the 18th Revised Japanese Pharmacopoeia. The properties of these macrogols vary depending on the molecular weight, and can be liquid, paste, powder, or flake at room temperature, and can be combined to adjust the viscosity, feel, etc. One or more types of macrogols can be used.

[0014] The average molecular weight of the macrogol is as follows. The measurement method is as described in the corresponding item of the Pharmaceutical Excipients Standards 2018 or the 18th Edition of the Japanese Pharmacopoeia. Macrogol 200: 190-210 Macrogol 300: 285-315 Macrogol 400: 380-420 Macrogol 600: 570-630 Macrogol 1000: 950-1050 Macrogol 1540: 1300-1600 Macrogol 4000: 2600-3800 Macrogol 6000: 7300-9300 Macrogol 20000: 15000~25000

[0015] In the present invention, it is preferable to use one or more macrogols having an average molecular weight in the range of 190 to 9300, particularly 190 to 3800, particularly 380 to 3800 in combination. It is also preferable to use one or more macrogols having an average molecular weight in the range of 190 to 1600, particularly 285 to 1050, particularly 380 to 630, particularly 380 to 420 in combination with one or more macrogols having an average molecular weight in the range of 2600 to 9300, particularly 2600 to 3800 in combination. It is also preferred to use one or more types of macrogols having an average molecular weight in the range of 2600 to 9300 (especially 2600 to 3800) in a ratio of 0.01 part by mass or more, 0.1 part by mass or more, or 0.2 part by mass or more, and 2 parts by mass or less, 1 part by mass or less, or 0.5 parts by mass or less, per part by mass of macrogols having an average molecular weight in the range of 190 to 1600 (especially 285 to 1050, particularly 380 to 630, particularly 380 to 420). It is particularly preferred to use a combination of Macrogol 400 and Macrogol 4000, and it is particularly preferred to use Macrogol 4000 in a ratio of 0.01 part by mass or more, 0.1 part by mass or more, or 0.2 part by mass or more, and 2 parts by mass or less, 1 part by mass or less, or 0.5 part by mass or less, per part by mass of Macrogol 400. If the content falls within the above range, the composition for external use will be less likely to adhere to or soak into knitted fabrics and will be easier to wash off.

[0016] (3) External composition Macrogol is contained in a composition for external use. The composition for external use may be a pharmaceutical composition, a cosmetic composition, a quasi-drug composition, etc. Also, it may be a composition for external use on the skin, a composition for external use on the mucous membrane, etc. Dosage forms of compositions for external use include ointments.

[0017] Macrogols may be contained at a concentration of 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, or 65% by mass or more, and 100% by mass or less, 90% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, or 70% by mass or less, based on the total amount of the topical composition. Within this range, the topical composition is less likely to adhere to or penetrate into the knitted fabric and is easily washed off.

[0018] The composition for external use may contain a base other than macrogol as long as the effect of the present invention is not impaired. Oily bases include hydrocarbons such as petrolatum (white petrolatum, yellow petrolatum), gelling hydrocarbons (such as Plastibase), ozokerite, ceresin, microcrystalline wax, squalene, squalane, α-olefin oligomers, paraffin, liquid paraffin, and light liquid paraffin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, and behenyl alcohol; and cholesterol, phytosterol, and phytosteryl hydroxystearate. sterols; vegetable fats such as shea butter, carnauba wax, cocoa butter, and candelilla wax; vegetable oils such as avocado oil, olive oil, camellia oil, macadamia nut oil, evening primrose oil, jojoba oil, rapeseed oil, egg yolk oil, sesame oil, castor oil, safflower oil, cottonseed oil, soybean oil, tea seed oil, rice bran oil, rice germ oil, wheat germ oil, peanut oil, sunflower oil, almond oil, corn oil, coconut oil, orange oil, sage oil, palm oil, mink oil, meadowfoam oil, lavender oil, rosemary oil, and rosehip oil; lano animal fats and oils such as phosphorus, orange roughy oil, squalane, horse oil, spermaceti, and beeswax; hydrogenated oils; silicone oils such as methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra 2-ethylhexanoate, and caprylic / capric triglyceride.

[0019] Examples of the aqueous base include, in addition to water and buffer solutions, lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, and isoprene glycol; synthetic polymers such as polyvinylpyrrolidone, carboxyvinyl polymer, and acrylic acid / alkyl methacrylate copolymer; natural polymers such as carrageenan, alginic acid, cellulose, guar gum, quince seed, dextran, gellan gum, dextrin, and maltodextrin; natural polymer derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, and cationized guar gum; and glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether. When a base other than macrogol is contained, an oil base is preferable, among which a hydrocarbon base is preferable, and petrolatum is particularly preferable. In addition, a powder such as starch can also be blended as a base. One or more bases other than macrogol can be used.

[0020] In the case of a topical composition containing a base other than macrogol (particularly an oily base, particularly a hydrocarbon base, particularly petrolatum), the ratio of macrogol to the total amount of the base can be 10% by mass or more, 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, or 80% by mass or more, and 100% by mass or less, 95% by mass or less, 90% by mass or less, 80% by mass or less, 75% by mass or less, or 70% by mass or less. Within this range, the topical composition is less likely to soak into knitted fabrics and is easily washed off.

[0021] In the case of a topical composition containing an oily base (particularly a hydrocarbon base, especially petrolatum), the total amount of the oily base can be 0.01% by mass or more, 0.1% by mass or more, 1% by mass or more, 5% by mass or more, or 10% by mass or more, and 30% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, 5% by mass or less, or 1% by mass or less, based on the total amount of macrogols. If the amount is within this range, the topical composition is less likely to soak into the knitted fabric and is easily washed off.

[0022] The composition for external use may contain, in addition to macrogol and other bases, additives and physiologically or pharmacologically active ingredients used in medicines, cosmetics, and quasi-drugs. The additives and physiologically or pharmacologically active ingredients may be used alone or in combination. They may be used in a range that does not impair the effects of the present invention. Examples of additives include surfactants such as polyoxyethylene hydrogenated castor oil, preservatives such as parabens, and antioxidants such as sodium edetate. Examples of physiologically or pharmacologically active ingredients include analgesics / antipruritics such as ethyl aminobenzoate, local anesthetics such as lidocaine, anti-inflammatory agents such as hydrocortisone acetate, allantoin, and zinc oxide, cooling agents such as l-menthol, antibacterial ingredients such as isopropyl methylphenol, and vitamins such as tocopherol acetate.

[0023] The topical composition preferably contains macrogol and an oily component, such as an oily base (e.g., the oily bases exemplified above, especially hydrocarbon bases, especially petrolatum), paraben, ethyl aminobenzoate, lidocaine, hydrocortisone acetate, l-menthol, isopropyl methylphenol, tocopherol acetate, etc. EXAMPLES

[0024] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these. (1) Test preparation The compositions of the preparations used in the evaluation of penetration, skin adhesion, and removability are as follows. Example 1 (ointment) Ethyl aminobenzoate 2g Lidocaine 2.4g Hydrocortisone acetate 0.5g Zinc oxide 10g l-Menthol 0.2g Isopropyl methylphenol 0.1g Allantoin 0.5g Tocopherol acetate 1g Macrogol 400 50g Macrogol 4000 20g Vaseline - 10g Corn starch (as needed) Polyoxyethylene hydrogenated castor oil (appropriate amount) Paraben (moderate amount) Sodium edetate (appropriate amount) (The content of each ingredient is the amount per 100 g of the preparation.)

[0025] Example 2 (ointment) Macrogol 400 50g Macrogol 4000 50g (The content of each ingredient is the amount per 100 g of the preparation.)

[0026] Comparative Example 1 (Ointment) Vaseline 100g (The petrolatum content is the amount per 100 g of the preparation.)

[0027] Comparative Example 2 (Ointment) Prednisolone acetate 0.5g Lidocaine 3g Allantoin 1g Vitamin E acetate 2.5g White petrolatum (appropriate amount) Medium chain triglyceride (appropriate amount) Glycerin monostearate (appropriate amount) (The content of each ingredient is the amount per 100 g of the preparation.)

[0028] Comparative Example 3 (Ointment) Hydrocortisone acetate 0.5g Diphenhydramine hydrochloride 1g Lidocaine 3g Isopropyl methylphenol 0.1g Tocopherol acetate 3g Vaseline (appropriate amount) Gelling hydrocarbons (appropriate amount) Microcrystalline wax (appropriate amount) Behenyl alcohol (appropriate amount) Beeswax (appropriate amount) Lanolin alcohol (appropriate amount) Propylene glycol (appropriate amount) Isopropyl myristate (appropriate amount) BHT moderate amount Polysorbate 80 (appropriate amount) Sorbitan sesquioleate (appropriate amount) (The content of each ingredient is the amount per 100 g of the preparation.)

[0029] (2) Evaluation of seepage suppression effect 100 mg of the preparations of Examples 1 and 2 and Comparative Examples 1 to 3 were applied and spread onto a 2.5 cm square area of ​​a cloth made of 66% cotton and 34% polyester by pressing the preparation onto the cloth with a spatula, and then dried overnight at room temperature. For Example 1 and Comparative Example 1, photographs of the surface (the surface coated with the preparation) of the cloth after drying are shown in the upper part of FIG. 1, and photographs of the back side are shown in the lower part of FIG. On the surface of the cloth to which the preparation of Example 1, an ointment containing macrogol, was applied, only slight stains of the preparation were observed, indicating that the preparation had hardly penetrated into the cloth. In contrast, the preparation of Comparative Example 1, an ointment containing only petrolatum, caused dark stains of the preparation on the cloth. Furthermore, while almost no stains of the preparation were observed on the back side of the cloth to which the preparation of Example 1 was applied, stains of the preparation of Comparative Example 1 were observed on the back side of the cloth, indicating that the preparation of Comparative Example 1 had penetrated into the cloth.

[0030] In addition, the degree of stains on the preparation-coated surface and the back surface was visually evaluated according to the following criteria. [Table 1]

[0031] (3) Evaluation of removability improvement effect In the section "(2) Evaluation of soak suppression effect," the preparations of each example were spread on the cloth, which was then dried overnight. The cloth was then washed in a washing machine for 30 minutes (12 minutes of washing, 15 minutes of rinsing, and 3 minutes of spin-drying) with water containing laundry detergent (Attack High Activity Biopower (product name)). Photographs of the formulation-applied surfaces of the fabrics in Example 1 and Comparative Example 1 are shown in FIG. The cloth to which the formulation of Example 1 was applied had no traces of the formulation remaining. It can be seen that the ointment containing macrogol can be easily washed off even if it adheres to or penetrates the skin. In contrast, the formulation of Comparative Example 1, which is an ointment containing only petrolatum, left stains of the formulation, and it was difficult to remove the soaked formulation.

[0032] In addition, the degree of stains on the preparation-coated surface and the back surface was visually evaluated according to the following criteria. [Table 2]

[0033] (3) Evaluation of skin adhesion The degree of skin adhesion of the preparations of Examples 1 and 2 and Comparative Examples 1 to 3 was visually evaluated according to the following criteria. [Table 3]

[0034] (4) Results The results of visual inspection of stains and adhesion are shown in Table 4. [Table 4] The macrogol-containing ointments of Examples 1 and 2 had higher skin adhesion than the petrolatum-containing ointments of Comparative Examples 1 to 3. In addition, because of the high skin adhesion, it was difficult for the ointments to adhere to knitted fabrics, and the feeling of use was also good. Furthermore, the ointment containing macrogol soaked into the knitted fabric much less than the ointment containing petrolatum. Ointments containing macrogol could be almost completely washed off with water even when they adhered to or soaked into knitted fabrics, but ointments containing petrolatum could hardly be washed off with water and soaked into the fabric. [Industrial Applicability]

[0035] The topical composition containing macrogol has good skin adhesion and is difficult to adhere to the skin, but is difficult to soak into knitted fabrics, and even if it does adhere to or soak into the fabric, it can be easily washed off. Therefore, it is suitable for application to skin parts that come into strong contact with underwear, such as delicate areas.

Claims

1. A method for inhibiting or reducing adhesion or penetration of a topical composition into knitted fabric, comprising incorporating macrogols into the topical composition.

2. A method for improving the removability of a topical composition from knitted fabrics by incorporating macrogols into the topical composition.

3. An agent for suppressing or reducing adhesion or penetration of a topical composition into knitted fabric, comprising macrogols and added to the topical composition for use.

4. An agent for improving the removability of a topical composition from a knitted fabric, which comprises macrogols and is added to the topical composition for use.

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