Composition containing polyphosphate and used for bleaching teeth or alleviating dentinal hypersensitivity

Abstract

To provide an oral composition containing potassium ions, phosphate ions, an organic zinc salt, and polyphosphate.SOLUTION: The present invention relates to an oral composition containing potassium ions, phosphate ions, an organic zinc salt, and polyphosphate. The composition of the present invention exhibits superior effects in bleaching teeth, strengthening teeth, and alleviating dentinal hypersensitivity, so that it can be effectively applied for the purposes of bleaching teeth, strengthening teeth, and alleviating, preventing or treating dentinal hypersensitivity.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a composition containing a polyphosphate for tooth bleaching or improving dentin hypersensitivity, and more specifically to a composition having an excellent whitening effect and a remarkable effect of improving dentin hypersensitivity. [Background technology]

[0002] A bright, white smile goes a long way in inspiring self-confidence in interpersonal relationships, and a confident smile also makes a better first impression.

[0003] In recent years, as interest in not only oral health but also tooth bleaching has increased, toothpaste compositions that exhibit tooth bleaching effects have become available on the market.

[0004] Tooth bleaching refers to a dental treatment procedure that whitens and brightens teeth that have become discolored due to various causes without damaging them, and in recent years, tooth bleaching products that can be used at home have been developed.

[0005] There are many types and methods of tooth bleaching, but most of them use high-concentration hydrogen peroxide to oxidize the staining factors of teeth, and have been used in dentistry for over 100 years, with their whitening effects proven. Peroxide acts as an oxidizing agent that oxidizes staining substances in teeth, and achieves whitening of teeth by transforming or decomposing the staining substances and removing them, but there are limitations to storage due to its high reactivity. In addition, the oxidation reaction using hydrogen peroxide is a very irritating reaction, and it causes strong irritation when it comes into contact with the lips, gums, tongue, etc.

[0006] Dentin hypersensitivity refers to a condition where the alveolar bone dissolves due to an inflammatory reaction caused by aging or disease, lowering the height of the alveolar bone, exposing the dentin that should be below the gum line, or where the teeth become temporarily weak or thin due to whitening toothpaste or dental whitening that contains hydrogen peroxide, causing the teeth to become sensitive to external stimuli. One method of alleviating dentin hypersensitivity is to change the balance of sodium ions and potassium ions in the oral cavity, which are the core of the neurotransmission system.

[0007] One method for changing the balance of ions in the oral cavity is to add an excess amount of potassium ions to increase the concentration of potassium ions in the oral cavity. Typical substances used are potassium nitrate, potassium chloride, potassium oxalate, or potassium phosphate.

[0008] Meanwhile, whitening or whitening toothpastes using hydrogen peroxide are designed to have a low pH formulation to stabilize hydrogen peroxide and improve its efficacy, which causes the hydroxyapatite on the tooth surface to dissolve in the acid, resulting in demineralization and weakening the teeth. One method for strengthening teeth is remineralization using the fluorine component contained in the toothpaste. The fluorine component remineralizes the hydroxyapatite on the tooth surface to fluoride apatite through an ion exchange reaction between the hydroxyl group and fluoride ion, strengthening the teeth. However, despite this remineralization process, there is a problem in that weakened teeth cannot be sufficiently strengthened.

[0009] Therefore, research has been actively conducted on pyrophosphate and polyphosphate as an alternative to hydrogen peroxide that is excellent for removing discoloration and inhibiting and preventing re-discoloration, but low molecular weight polyphosphate can form a chelate with dissolved calcium on the tooth surface or with supersaturated calcium in saliva, causing demineralization of the teeth and reducing their strength. On the other hand, pyrophosphate also removes calcium from the tooth surface, reducing the hardness of the teeth.

[0010] In addition, simply adding a remineralization agent such as calcium ions or phosphate ions, which are components of teeth, to solve the problem of reduced tooth strength has the problem that the stability of hydrogen peroxide decreases due to ionic activity, reducing the whitening effect due to chelate formation.

[0011] Under these circumstances, the inventors have conducted extensive research to solve the above problems, and as a result have developed a toothpaste composition containing potassium ions, a zinc compound, and a polyphosphate, which has excellent whitening effects. The inventors have confirmed that this composition can provide effects of strengthening teeth and improving dentin hypersensitivity, thereby eliminating consumer concerns about reduced tooth strength or dentin hypersensitivity caused by tooth bleaching, and have thus completed the present invention. [Prior art documents] [Non-patent literature]

[0012] [Non-Patent Document 1] KIM, Young-Sung, Journal of Periodontal and Implant Science, Volume 32 Issue 2, 371-378, 2002 Summary of the Invention [Problem to be solved by the invention]

[0013] An object of the present invention is to provide an oral composition comprising a potassium ion source, a phosphate ion source, an organo zinc compound, and a polyphosphate.

[0014] Another object of the present invention is to provide a pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising a potassium ion source, a phosphate ion source, an organo zinc compound, and a polyphosphate.

[0015] Another object of the present invention is to provide a use of a composition comprising a potassium ion source, a phosphate ion source, an organo zinc compound, and a polyphosphate for tooth bleaching, strengthening tooth strength, or improving dentin hypersensitivity. [Means for solving the problem]

[0016] These will be described in detail below. Note that each description and embodiment disclosed in the present invention is also applicable to other descriptions and embodiments. In other words, all combinations of various elements disclosed in the present invention are included in the present invention. In addition, the present invention is not limited to the following specific description.

[0017] The present invention relates to a composition for tooth bleaching, strengthening tooth strength, or improving dentin hypersensitivity, and the composition comprises potassium ions capable of improving dentin hypersensitivity, an organic zinc salt capable of filling vacant spaces in weakened teeth, and a polyphosphate salt having a whitening effect. It has been specifically confirmed that the composition of the present invention maintains an excellent whitening effect while exerting the effects of strengthening tooth strength and improving dentin hypersensitivity.

[0018] Hydroxyapatite, a component of teeth, is produced by the reaction of calcium ions and phosphate ions contained in saliva and / or toothpaste. Phosphate ions react with saliva and penetrate the tooth surface, strengthening the tooth.

[0019] Potassium phosphate and zinc stearate help to increase the hardness of tooth surfaces. Zinc ions harden tooth surfaces by replacing calcium to form zinc phosphate, which plays an important role in the remineralization of tooth surfaces, and zinc, which has antibacterial properties, is known to prevent bacterial contamination and enamel loss on tooth surfaces (Figure 1).

[0020] As shown in Figure 1, polyphosphates come into strong electrostatic contact with the tooth surface, forming a film carrying an excessive negative charge. When a divalent cation capable of binding two ions is introduced into the film, the cation and phosphate ion (PO4 3- ) serves to strengthen teeth by electrostatic bonding.

[0021] The present invention relates to a composition for simultaneously achieving tooth whitening and teeth enamel strengthening, and may contain potassium ions that easily penetrate into microcracks between teeth (Fig. 2). On the other hand, toothpaste containing potassium chloride or potassium oxalate to supply potassium ions increases the potassium ions in the microcracks of teeth without affecting the whitening effect, thereby inhibiting external stimuli such as hot and cold sensations from reaching the nerve transmission system of the dentin, and preventing oral irritation, but does not play a role in strengthening teeth.

[0022] The source of phosphate ions is determined by Le Châtelier's principle, as can be seen in the following remineralization mechanism: 3-), it increases the production of hydroxyapatite and fills gaps in teeth. However, in the mechanism by which phosphate ions remineralize teeth, polyphosphates compete with calcium ions to form chelates, and thus inhibiting the adhesion of polyphosphates to teeth can inhibit the whitening effect. Therefore, there is a demand for a method that contains phosphate ions, maintains the whitening effect, and strengthens teeth.

[0023] [ka]

[0024] In addition, when polyphosphate and zinc salt are included, the negative charge portion of polyphosphate binds to the zinc cation to form a chelate, so that the charge density of the anion of polyphosphate decreases, and the strength of binding to calcium ions on the tooth surface weakens, thereby reducing the whitening effect of pushing out and removing dental contaminants. Therefore, it is very important to maintain the zinc salt stably in the dosage form. For example, zinc chloride, which is quickly ionized in water, reacts with water to dissociate into zinc ions and chloride ions, and the zinc ions form a chelate with polyphosphate, so that the binding strength of polyphosphate to the tooth surface decreases. In contrast, organic zinc salts such as zinc citrate, zinc stearate, and zinc gluconate are formed by binding organic acids and zinc ions, and do not immediately dissociate even when in contact with water, but maintain stability due to electronic stabilization of the carboxyl group of the organic acid. Therefore, in the present invention, the stability of zinc salt is maintained in the dosage form by using zinc salts, particularly organic zinc salts.

[0025] In the present invention, potassium ions and phosphate ions are supplied separately or simultaneously as potassium phosphate and are allowed to coexist with an organic zinc salt. This allows the zinc ions partially dissociated in the composition to react with phosphate ions rather than with polyphosphate, thereby maintaining the whitening effect of the polyphosphate and binding to zinc phosphate to be delivered to the teeth to strengthen the tooth strength. It has been confirmed that all of the following effects can be obtained: whitening effect, strengthening of tooth strength, and improvement of dentin hypersensitivity, and this has led to the completion of the present invention.

[0026] One aspect of the present invention is an oral composition that includes a potassium ion source, a phosphate ion source, an organic zinc salt, and a polyphosphate salt.

[0027] In the present invention, the composition may be used for at least one purpose selected from the group consisting of tooth bleaching, strengthening tooth strength, and improving dentin hypersensitivity.

[0028] As used herein, "tooth bleaching" refers to removing substances that adhere to or penetrate into the tooth surface and enamel and cause a staining effect, or to modifying the chemical structure of the substances to remove the staining effect.

[0029] In this specification, "dentin hypersensitivity" means an independent disease in which temporary or persistent sharp pain occurs in response to external stimuli, separate from caries or other pathological causes. Dentin hypersensitivity is a condition where the exposed dentin of a tooth feels sensitive when it comes into contact with cold air or spicy foods, and occurs when the gum side of the tooth is eroded due to incorrect tooth brushing habits, excessive biting force, or dissolution by acid, when oral hygiene is poor, after periodontal treatment, after restorative treatment, or when the tooth is dissolved by acidification. The root cause of dentin hypersensitivity is the exposure of many dentinal tubules in the dentin of the tooth to the outside, which transmits all stimuli directly to the nerves in the dental pulp, causing pain by reacting more sensitively than usual to the same stimuli. Dentin hypersensitivity can present with a variety of symptoms, ranging from mild symptoms to intense and persistent pain, and because teeth do not regenerate due to their nature, taking painkillers or anti-inflammatory drugs is not a fundamental solution to dentin hypersensitivity. Dentin hypersensitivity can occur generally over the entire tooth, or it can be limited to specific areas such as the upper or lower jaw, right or left side. The areas where it most commonly occurs vary depending on the cause, but are mainly the canines and premolars, and it is known that the area where the most severe pain occurs is the gums, which are the border between the gums and the teeth, in more than 90% of cases.

[0030] In this specification, the term "improvement" means that the above-mentioned dentin hypersensitivity is reduced or eliminated, and is understood to be a broad concept including alleviation, prevention, treatment, and the like.

[0031] In the present invention, the potassium ion source is at least one selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), potassium nitrate (KNO3), potassium chloride (KCl) and potassium oxalate (K2C2O4), but is not limited thereto.

[0032] As used herein, a "potassium ion source" refers to a source of potassium ions (K +For example, potassium dihydrogen phosphate (KH2PO4) provides potassium ions (K + ) and phosphate ions (PO4 3- ), it may be called a potassium ion source or a phosphate ion source.

[0033] In the present invention, the phosphate ion source is at least one selected from the group consisting of potassium dihydrogen phosphate (KH2PO4), dipotassium hydrogen phosphate (K2HPO4), tripotassium phosphate (K3PO4), sodium dihydrogen phosphate (NaH2PO4), disodium hydrogen phosphate (Na2HPO4) and trisodium phosphate (Na3PO4), but is not limited thereto.

[0034] As used herein, a "phosphate ion source" refers to a source of phosphate ions (PO4 3- For example, dipotassium hydrogen phosphate (K2HPO4) provides potassium ions (K + ) and phosphate ions (PO4 3- ), it may be called a potassium ion source or a phosphate ion source.

[0035] In the present invention, the composition contains 0.10 to 10.00% by weight of a potassium ion source relative to the total weight of the composition, so that the composition has a stable dosage form and exhibits an excellent effect of improving dentin hypersensitivity.

[0036] Therefore, the composition contains the potassium ion source in the composition at 0.10 to 10.00% by weight, 0.10 to 9.00% by weight, 0.10 to 8.00% by weight, 0.10 to 7.00% by weight, 0.10 to 6.00% by weight, 0.10 to 5.00% by weight, 0.10 to 4.00% by weight, 0.10 to 3.00% by weight, 0.20 to 10.00% by weight, 0.20 to 9.00% by weight, 0.20 to 8.00% by weight, 0.20 to 7.00% by weight, The content may be 0.20 to 6.00% by weight, 0.20 to 5.00% by weight, 0.20 to 4.00% by weight, 0.20 to 3.00% by weight, 0.30 to 10.00% by weight, 0.30 to 9.00% by weight, 0.30 to 8.00% by weight, 0.30 to 7.00% by weight, 0.30 to 6.00% by weight, 0.30 to 5.00% by weight, or 0.30 to 4.00% by weight, and more specifically, the content may be 0.10 to 3.00% by weight.

[0037] In the present invention, the composition contains 0.10 to 10.00% by weight of a phosphate ion source relative to the total weight of the composition, so that the composition has a stable dosage form and exhibits an excellent effect of improving dentin hypersensitivity.

[0038] Therefore, the composition contains the phosphate ion source in the composition at 0.10 to 10.00% by weight, 0.10 to 9.00% by weight, 0.10 to 8.00% by weight, 0.10 to 7.00% by weight, 0.10 to 6.00% by weight, 0.10 to 5.00% by weight, 0.10 to 4.00% by weight, 0.10 to 3.00% by weight, 0.20 to 10.00% by weight, 0.20 to 9.00% by weight, 0.20 to 8.00% by weight, 0.20 to 7.00% by weight, The content may be 0.20 to 6.00% by weight, 0.20 to 5.00% by weight, 0.20 to 4.00% by weight, 0.20 to 3.00% by weight, 0.30 to 10.00% by weight, 0.30 to 9.00% by weight, 0.30 to 8.00% by weight, 0.30 to 7.00% by weight, 0.30 to 6.00% by weight, 0.30 to 5.00% by weight, or 0.30 to 4.00% by weight, and more specifically, the content may be 0.10 to 3.00% by weight.

[0039] In the present invention, the organic zinc salt is at least one selected from the group consisting of zinc citrate, zinc stearate, zinc gluconate, and zinc carbonate hydroxide, but is not limited thereto.

[0040] In the present invention, the organic zinc salt may not contain zinc chloride.

[0041] In the present invention, the organic zinc salt that fills the voids in teeth is contained in an amount of 0.10 to 3.00% by weight based on the total weight of the composition, so that excellent whitening effect is maintained and at the same time, tooth strength strengthening effect is exerted.

[0042] Thus, the composition may contain the organic zinc salt in an amount of 0.10 to 3.00% by weight, 0.10 to 2.80% by weight, 0.10 to 2.60% by weight, 0.10 to 2.40% by weight, 0.10 to 2.20% by weight, or 0.10 to 2.00% by weight, or more specifically, 0.10 to 1.80% by weight.

[0043] In the present invention, the polyphosphate is at least one selected from the group consisting of linear polyphosphate, cyclic polyphosphate, and branched polyphosphate, but is not limited thereto.

[0044] In the present invention, the polyphosphate is at least one selected from the group consisting of sodium tripolyphosphate, sodium metaphosphate, and sodium polyphosphate, but is not limited thereto.

[0045] In the present invention, the sodium metaphosphate is sodium hexametaphosphate, but is not limited thereto.

[0046] In this specification, the term "polyphosphate" generally refers to a salt of a polymeric oxyanion composed of a tetrahedral PO4 structural unit in which oxygen atoms are bonded together by sharing. The polyphosphate in the present invention has at least three repeating phosphate units, and in this specification, "phosphate ion" and "polyphosphate" should be clearly distinguished. For example, sodium hexametaphosphate has the structure of chemical formula 2.

[0047] [ka]

[0048] In the present invention, the polyphosphate exhibiting a tooth-whitening effect is contained in an amount of 1.50 to 10.00% by weight based on the total weight of the composition, so that it causes less oral cavity irritation and exhibits an excellent whitening effect.

[0049] Thus, the composition may contain the polyphosphate in the composition at 1.50 to 10.00 wt%, 1.50 to 9.00 wt%, 1.50 to 8.00 wt%, 3.00 to 10.00 wt%, 3.00 to 9.00 wt%, 3.00 to 8.00 wt%, 5.00 to 10.00 wt%, 5.00 to 9.00 wt%, or 5.00 to 8.00 wt%, and more specifically may contain 7.50 wt%.

[0050] In the present invention, the composition contains 0.1 to 3.0% by weight of the potassium ion source, 0.1 to 3.0% by weight of the phosphate ion source, 0.1 to 3.0% by weight of the organic zinc salt, and 1.5 to 10.0% by weight of the polyphosphate, but is not limited thereto.

[0051] The composition can be applied to any oral product used for tooth bleaching, tooth strength strengthening, or dentin hypersensitivity in the oral cavity, such as toothpaste, oral spray, oral cleanser, oral ointment, oral cleaner, gum, candy, oral patch, etc. The oral product can be in the form of a liquid phase, solid phase, suspension, gel, film, or patch, but is not limited thereto. When the composition of the present invention is provided in the form of a patch, the patch can be of any type, such as a type that dissolves in the oral cavity or a type that is attached to the oral cavity and then peeled off.

[0052] The products made from the compositions of the present invention can be manufactured by methods commonly used in the art.

[0053] In order to apply the composition of the present invention to oral products, the composition may further contain suitable additives, carriers, etc., which can be appropriately selected and combined by a person having ordinary knowledge in the technical field to which the present invention pertains.

[0054] Oral products using the composition of the present invention may contain, in addition to the composition containing potassium ions, phosphate ions, an organic zinc salt, and a polyphosphate, ingredients that are commonly used in oral products, such as abrasives, humectants, binders, foaming agents, sweeteners, preservatives, medicinal ingredients, flavorings, pigments, solvents, whitening agents, solubilizing agents, or pH adjusters.

[0055] Another aspect of the present invention is a pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising a composition comprising a potassium ion source, a phosphate ion source, an organic zinc salt, and a polyphosphate.

[0056] As used herein, "prevention" refers to any action that inhibits or delays the onset of dentin hypersensitivity by administering the composition.

[0057] As used herein, "treatment" refers to any action that improves or beneficially alters the symptoms of dentin hypersensitivity by administering the composition.

[0058] The pharmaceutical composition of the present invention may further comprise a pharma- ceutically acceptable carrier.

[0059] As used herein, "pharmaceutical acceptable" means something that does not irritate a subject when administered, does not impair the biological activity and properties of the compound being administered, and is commonly used in the pharmaceutical field.

[0060] As used herein, a "subject" refers to a mammal, including a human, such as, but not limited to, a human, monkey, cow, horse, sheep, pig, cat, dog, mouse, rat, rabbit, or guinea pig.

[0061] As used herein, "administration" means providing a given substance to a subject by any suitable method, and the route of administration of the pharmaceutical composition of the present invention can be any common route that can deliver the substance to the target tissue.

[0062] In the present invention, the carrier may be any carrier commonly used in the art, including, but not limited to, saline, sterile water, Ringer's solution, buffered saline, albumin injection, lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, maltodextrin, glycerin, ethanol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate, mineral oil, and combinations thereof.

[0063] In the present invention, the pharmaceutical composition may be used by adding other pharma- ceutically acceptable additives such as excipients, diluents, antioxidants, buffers, bacteriostatic agents, etc., as necessary, and may further include fillers, extenders, wetting agents, disintegrants, dispersants, surfactants, binders, lubricants, etc. Effect of the Invention

[0064] The present invention relates to an oral composition containing potassium ions, phosphate ions, an organic zinc salt, and a polyphosphate, and the composition of the present invention has a whitening effect as well as the effects of strengthening tooth strength and improving dentin hypersensitivity. [Brief description of the drawings]

[0065] [Figure 1] FIG. 2 is a schematic diagram showing the tooth surface remineralization process of a composition according to an embodiment of the present invention. [Diagram 2] FIG. 1 is a schematic diagram showing the process by which potassium ions penetrate into microcracks between teeth to improve dentin hypersensitivity. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0066] The present invention will be described in more detail below with reference to examples. However, these examples are merely preferred embodiments of the present invention, and the present invention is not limited thereto. Note that technical matters not described in this specification are fully understood and easily implemented by skilled engineers in the technical field of the present invention or a similar technical field.

[0067] Preparation Example: Preparation of compositions of Examples and Comparative Examples In order to confirm the effect of a composition depending on the constituent components and the content thereof, compositions of Examples 1 to 10 and Comparative Examples 1 to 6 were prepared.

[0068] Specifically, carrageenan and xanthan gum were mixed with glycerin and polyethylene glycol, purified water was added, a small amount of raw materials were added and dissolved, and then inorganic solids, surfactants and flavorings were added to prepare the oral composition. Specific ingredients and contents are shown in Tables 1 and 2.

[0069] [Table 1]

[0070] [Table 2]

[0071] Experimental example 1: Confirmation of in vitro tooth bleaching effect (confirmation of stain removal power) The tooth bleaching effect of the compositions of the Examples and Comparative Examples was confirmed using hydroxyapatite disks. Hydroxyapatite is a substance used as a material for artificial teeth and tissue repair, and the ability of the compositions of the Examples and Comparative Examples to remove contaminants from hydroxyapatite disks was measured as follows.

[0072] Specifically, hydroxyapatite powder was made into a paste with a polyvinyl alcohol aqueous solution, compressed with a pressure of more than 10 tons using a compressor, and then sintered at 1,000°C to create a hydroxyapatite disc. Stain was applied to the disc using coffee, tea, and mucin solutions to prepare samples, and the disc was brushed 5,400 times using a toothbrushing device that can apply a load of 250g. The stain removal ability was then evaluated by measuring the color change using a Minolta CR-321 color difference meter. The results are shown in Tables 3 and 4.

[0073] [Table 3]

[0074] [Table 4]

[0075] As a result of the evaluation, as shown in Tables 3 and 4, the compositions of Examples 1 to 10, which contain potassium ions, phosphate ions, and an organic zinc salt together with polyphosphate exhibiting a tooth bleaching effect, were found to have excellent whitening effects, with measured stain removal powers ranging from a minimum of 24.10 (Example 1) to a maximum of 27.78 (Example 2).

[0076] In particular, it was confirmed that the compositions of Examples 1 to 10 exhibited equal or superior whitening effects to the composition of Comparative Example 4 (25.10), which did not contain potassium ions, phosphate ions, or organic zinc salts, but contained only polyphosphates.

[0077] Furthermore, it was confirmed that the compositions of Examples 1 to 10 exhibited superior whitening effects compared to those that did not contain potassium ions (Comparative Examples 1, 3, and 5), those that did not contain phosphate ions (Comparative Examples 3 and 5), and those that did not contain an organic zinc salt (Comparative Examples 1, 2, and 6).

[0078] Therefore, it was confirmed that an appropriate combination of the constituent components of potassium ions, phosphate ions, organic zinc salts and polyphosphate salts exhibits a superior whitening effect, whereas the use of potassium ions, phosphate ions or zinc salts alone significantly reduces the tooth whitening effect.

[0079] Experimental example 2: Confirmation of tooth strength strengthening effect The composition prepared in the above Preparation Example was used to evaluate the change in tooth hardness.

[0080] Specifically, the evaluation method consisted of preparing dental specimens by drilling bovine teeth, fitting them with appropriate tools, and then polishing them. The specimens were etched with 0.1 M lactic acid, and then the initial hardness was measured with a Vickers hardness tester. Eight specimens were grouped into groups and subjected to pH cycling (5 times) as follows to measure the final hardness:

[0081] [Table 5]

[0082] Microhardness analysis was performed after caries formation (T1) and after remineralization treatment (T2), and the results are shown in Tables 6 and 7.

[0083] [Table 6]

[0084] [Table 7]

[0085] As a result of the evaluation, as shown in Tables 6 and 7, it was confirmed that the tooth hardness in Examples 1 to 10 is significantly increased compared to Comparative Example 4, which does not contain potassium ions, phosphate ions, and organic zinc salt. In addition, it was confirmed that the tooth strengthening effect is relatively high when a zinc salt stabilized as an organic acid is used, compared to Comparative Example 6, which contains zinc chloride, in which zinc is not stable. This suggests that in Comparative Example 6, zinc reacts first in the dosage form, so that it does not affect the tooth strengthening effect.

[0086] Therefore, it was confirmed that the composition of the present invention exhibits an excellent tooth bleaching effect as well as an effect of strengthening tooth hardness.

[0087] Experimental example 3: Confirmation of the effect of improving dentin hypersensitivity Volunteers were tested using an electric pulp test (EPT).

[0088] The electrical pulp testing method for measuring dentin hypersensitivity was evaluated by referring to a published paper (Non-Patent Document 1), and a higher value than the previous measurement was evaluated as an improvement in dentin hypersensitivity.

[0089] In each experiment, a baseline electrical pulp test was performed before using the composition, and then again two weeks after using the composition. The results are shown in Tables 8 and 9.

[0090] [Table 8]

[0091] [Table 9]

[0092] As a result of the evaluation, as shown in Tables 8 and 9, it was confirmed that the compositions of Examples 1, 3, 6 and 7 containing potassium ions, phosphate ions, an organic zinc salt and a polyphosphate salt had increased resistance to stimuli and were relatively excellent in improving dentin hypersensitivity, compared to the compositions of Comparative Examples 1 and 4 not containing these. In contrast, it was confirmed that the composition not containing potassium ions, phosphate ions and a zinc salt (Comparative Example 4) had increased sensitivity to stimuli and rather worsened dentin hypersensitivity to some extent.

[0093] To summarize the results of these experimental examples, the whitening effect, tooth strengthening effect, and dentin hypersensitivity improving effect were confirmed, and it was confirmed that the composition of the present invention containing potassium ions, phosphate ions, an organic zinc salt, and a polyphosphate salt can maintain an excellent tooth whitening effect, effectively increase tooth strength, and improve dentin hypersensitivity. Therefore, it is suggested that the composition of the present invention is useful for tooth bleaching, tooth strength strengthening, and dentin hypersensitivity improving applications.

[0094] From the above description, a person skilled in the art to which the present invention pertains will understand that the present invention can be implemented in other specific forms without changing its technical ideas or essential features. It should be understood that the above examples are merely illustrative and not limiting. The present invention should be interpreted as including all modifications or alterations derived from the meaning and scope of the claims and their equivalent concepts, rather than the specification.

Claims

1. An oral composition comprising a potassium ion source, a phosphate ion source, an organic zinc salt, and a polyphosphate.

2. The potassium ion source is potassium dihydrogen phosphate (KH ２ P.O. ４ ), dipotassium hydrogen phosphate (K ２ H.P.O. ４ ), tripotassium phosphate (K ３ P.O. ４ ), potassium nitrate (KNO ３ ), potassium chloride (KCl) and potassium oxalate (K ２ C ２ O ４ The composition according to claim 1, wherein the at least one selected from the group consisting of

3. The phosphate ion source is potassium dihydrogen phosphate (KH ２ P.O. ４ ), dipotassium hydrogen phosphate (K ２ H.P.O. ４ ), tripotassium phosphate (K ３ P.O. ４ ), sodium dihydrogen phosphate (NaH ２ P.O. ４ ), disodium hydrogen phosphate (Na ２ H.P.O. ４ ) and trisodium phosphate (Na ３ P.O. ４ The composition according to claim 1, wherein the at least one selected from the group consisting of

4. 2. The composition of claim 1, wherein the organic zinc salt is at least one selected from the group consisting of zinc citrate, zinc stearate, zinc gluconate, and zinc carbonate hydroxide.

5. The composition according to claim 1 , wherein the polyphosphate is at least one selected from the group consisting of linear polyphosphates, cyclic polyphosphates, and branched polyphosphates.

6. 2. The composition according to claim 1, wherein the polyphosphate is at least one selected from the group consisting of sodium tripolyphosphate, sodium metaphosphate, and sodium polyphosphate.

7. 7. The composition of claim 6, wherein the sodium metaphosphate is sodium hexametaphosphate.

8. 2. The composition of claim 1, wherein the composition comprises 0.1 to 3.0% by weight of the potassium ion source, 0.1 to 3.0% by weight of the phosphate ion source, 0.1 to 3.0% by weight of the organic zinc salt, and 1.5 to 10.0% by weight of the polyphosphate salt.

9. The composition according to any one of claims 1 to 8, wherein the composition is intended for at least one use selected from the group consisting of tooth bleaching, strengthening tooth strength, and improving dentin hypersensitivity.

10. An oral product comprising a composition according to any one of claims 1 to 8.

11. 11. The oral product of claim 10, wherein the oral product is at least one selected from the group consisting of toothpaste, mouth spray, mouthwash, mouth ointment, mouth freshener, gum, candy, and oral patch.

12. A pharmaceutical composition for preventing or treating dentin hypersensitivity, comprising the composition according to any one of claims 1 to 8.

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