Bicarbonate bath agent and method for producing the same

Abstract

To provide a bicarbonate bath agent and a method for producing the same.SOLUTION: A material is employed that contains a bicarbonate (sodium hydrogen carbonate), an organic acid (citric acid, succinic acid, fumaric acid, and malic acid), a chlorine-neutralizing compound (L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate), and a lubricant (alkanesulfonate having 6 to 18 carbon atoms, olefinsulfonate, and sucrose fatty acid ester). The material is subjected to compression molding such that: the weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7; the weight ratio of the chlorine-neutralizing compound to the tablet is 1 / 1500 to 1 / 30; and the tablet hardness is 20 kgf or more.SELECTED DRAWING: Figure 2

Description

[Technical field]

[0001] The present invention relates to a bicarbonate bath additive and a method for producing the same. [Background technology]

[0002] Prewar diseases were caused by bacteria, such as pneumonia, tuberculosis, dysentery, and malaria, and what was needed for immunity was granulocytes, which are controlled by the sympathetic nervous system and work at low body temperature. However, with the invention of penicillin and the emergence of antibiotics, these prewar bacterial diseases were eradicated, and after the war, diseases were mainly caused by lifestyle-related diseases and viruses. The immunity against such lifestyle-related diseases and viruses is lymphocytes, which are controlled by the parasympathetic nervous system and work at high body temperature. If the patient's normal body temperature is high (around 36.5°C), the natural immunity of NK cells (natural killer cells) can attack small foreign substances such as cancer cells and virus-infected cells. However, if the patient's normal body temperature is low, the natural immunity does not function properly, so the patient must develop a high fever and attack foreign substances using acquired immunity such as T cells and B cells, which work at 38°C or higher. In other words, a low body temperature weakens the immunity.

[0003] Here, after the war, the Water Supply Act set an unlimited chlorine addition standard of 0.1 ppm or more, which left chlorine in tap water, and the sebum ceramide of the skin barrier that protects the body was taken away by resident bacteria every night, destroying the barrier structure. As a result, the residual chlorine in tap water was absorbed through the skin and accumulated in subcutaneous fat, causing the adrenal cortex to constantly secrete stress hormones such as cortisol and adrenaline, causing the autonomic nervous system to constantly tense the sympathetic nervous system, constricting blood vessels to reduce blood flow, and lowering body temperature. Currently, the average body temperature of the nation's citizens has dropped by 1°C, and as the immune system weakens with the drop in body temperature, cancer, diabetes, heart disease, and coronavirus become more severe.

[0004] In Europe and other countries, the period of hot spring therapy is set for health insurance, where hot spring therapy is applied, but the period is usually four weeks, and it is said that it takes about four months for a person's body to change for the better. The human body is a chemical protein synthesis factory where almost everything except the bones is replaced, but people with low body temperature do not receive enough nutrient oxygen or hormone enzymes when repairing and re-synthesizing organs, and waste is not excreted sufficiently. In addition, low body temperature causes all kinds of allergies and lifestyle-related diseases due to reduced immunity and reduced enzyme reactions. Also, since we fall asleep by lowering our body temperature, with low body temperature we cannot fall asleep deeply, so the first 90 minutes of non-REM sleep, when growth hormone is fully produced, becomes shallow, and organs cannot be repaired sufficiently, which causes illness.

[0005] In this way, lifestyle-related diseases are caused by a cold body and low blood flow, and in order to improve the symptoms, it is important to increase blood flow and raise body temperature. One method for this is to use bicarbonate bath therapy, in which bathers bathe in water containing dissolved bath additives that generate bicarbonate ions (so-called bicarbonate bath therapy). This bicarbonate bath therapy uses the homeostatic function of the body, which causes the body to take in oxygen quickly from the lungs by disrupting the gas balance between oxygen and bicarbonate ions due to the penetration of bicarbonate ions into the blood vessels in the bath.

[0006] As a bicarbonate bath additive suitable for this bicarbonate hot bath therapy, the inventors of the present application have proposed a method for producing tablets and tablets having a certain degree of hardness by compression molding using an organic acid as a compound that neutralizes with a compound as a carbon dioxide gas generating source, i.e., bicarbonate salt (sodium bicarbonate, potassium bicarbonate), in the presence of polyethylene glycol (Patent Documents 1 to 3). Inside the tablets produced by these methods, a vigorous and efficient neutralization reaction occurs, and by continuously releasing carbon dioxide gas bubbles of the smallest possible size for a certain period of time, most of the generated carbon dioxide gas can be dissolved in water without escaping into the air. In addition, by designing the pH to be neutral immediately after dissolution, the bicarbonate ions in the water can be concentrated, and the carbon dioxide gas that comes into contact with the skin due to the pH of the aqueous solution can easily become bicarbonate ions and become highly concentrated when combined with the bicarbonate ions that are originally present, which can increase the absorption of bicarbonate ions from the skin into the blood vessels. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Patent No. 5588490 [Patent Document 2] Patent No. 5877778 [Patent Document 3] Patent No. 6525945 [Non-patent literature]

[0008] [Non-Patent Document 1] Nobuhiro Maruyama and Shigeji Koboshi, "No. 29 Development of bicarbonate ion-citric acid bath additives and measures to prevent illness", Journal of the Japanese Society of Balneology, Climatology, and Physical Medicine, Vol. 78, No. 1 Summary of the Invention [Problem to be solved by the invention]

[0009] All bodily reactions, including the reactions of all organs, blood flow, and hormone secretion, are unconscious reactions commanded by the autonomic nervous system. Since both increased blood flow and hormone secretion occur under conditions of parasympathetic dominance, even taking a bicarbonate bath will not increase blood flow sufficiently when the sympathetic nervous system is dominant under stress. In other words, if you use bath additives that do not increase the bicarbonate ion concentration in the water sufficiently, or if you take a bath in tap water with residual chlorine, you will not be able to efficiently cause the vascular endothelium to secrete nitric oxide (NO) and increase blood flow.

[0010] Therefore, when taking a bicarbonate bath, it is important to bathe in a way that switches on the parasympathetic nervous system in the presence of a sufficient concentration of bicarbonate ions. By doing so, the homeostatic function of the body is switched on, and NO, a sphincter relaxing hormone, is secreted into the capillary endothelium, which expands the blood vessels and increases blood flow, thereby warming the body and raising body temperature. By maintaining a high body temperature and a parasympathetic dominant state, the natural immunity of lymphocytes is activated, improving immunity, and the self-healing ability is increased, improving symptoms of illness and disorders.

[0011] In this way, it is possible to improve the symptoms of various diseases caused by chills by raising body temperature through a bicarbonate bath, but in order to do so, it is important to use a bicarbonate bath agent that has a high bicarbonate ion concentration in the bath and the ability to remove residual chlorine in tap water. Here, by using the tablets of Patent Documents 1 to 3, it is possible to increase the bicarbonate ion concentration in the bath and the ability to remove residual chlorine in tap water compared to other bath agents available on the market, but in order to sufficiently increase the bicarbonate ion concentration in the bath, maintain this state for a long time, and effectively remove residual chlorine in tap water to expand capillaries to double size and instantly increase blood flow, it is necessary to appropriately set the materials constituting the bicarbonate bath agent, appropriately set the weight ratio of those materials, and further, to make the hardness of the tablet compressed and molded from those materials to a predetermined value or more.

[0012] The present invention has been made in consideration of the above-mentioned problems, and its main object is to provide a bicarbonate bath additive and a manufacturing method thereof that can sufficiently increase the bicarbonate ion concentration in water, maintain that state for a long time, and effectively remove residual chlorine in tap water. [Means for solving the problem]

[0013] One aspect of the present invention is a bicarbonate bath additive comprising a tablet formed by compression molding a material containing a bicarbonate, an organic acid, a chlorine neutralizing compound, and a lubricant, wherein the bicarbonate is sodium hydrogen carbonate, the organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid, the chlorine neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate, the lubricant is at least one selected from alkanesulfonates having 6 to 18 carbon atoms, olefin sulfonates, and sucrose fatty acid esters, the weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7, the weight ratio of the chlorine neutralizing compound to the tablet is 1 / 1500 to 1 / 30, and the hardness of the tablet is 20 kgf or more.

[0014] One aspect of the present invention is a method for producing a bicarbonate bath additive comprising a tablet containing a bicarbonate, an organic acid, a chlorine-neutralizing compound, and a lubricant, the bicarbonate being sodium hydrogen carbonate, the organic acid being at least one selected from citric acid, succinic acid, fumaric acid, and malic acid, the chlorine-neutralizing compound being at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate, and the lubricant being an alkane sulfonic acid having 6 to 18 carbon atoms. the weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7, the weight ratio of the chlorine neutralizing compound to the tablet is 1 / 1500 to 1 / 30, a granulated product of the bicarbonate is prepared, a mixture of the organic acid, the chlorine neutralizing compound, and the lubricant is mixed with the granulated product, and the mixture is compressed and molded to prepare the tablet having a hardness of 20 kgf or more. Effect of the Invention

[0015] According to the bicarbonate bath additive and its manufacturing method of the present invention, the bicarbonate ion concentration in the bath water can be sufficiently increased and maintained for a long period of time, while residual chlorine in tap water can be effectively removed.

[0016] The reason is that the bicarbonate bath agent is manufactured by using materials containing bicarbonate (sodium hydrogen carbonate), organic acids (citric acid, succinic acid, fumaric acid, malic acid), chlorine neutralizing compounds (L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate), and lubricants (alkanesulfonates with 6 to 18 carbon atoms, olefinsulfonates, sucrose fatty acid esters), with a weight ratio of organic acid to bicarbonate of 1 / 8 to 2 / 7, a weight ratio of chlorine neutralizing compounds to tablets of 1 / 1500 to 1 / 30, and compression molding the materials so that the tablet hardness is 20 kgf or more. By using a bicarbonate bath agent with this composition, the capillaries can be expanded to double size, and blood flow can be increased in one go. [Brief description of the drawings]

[0017] [Figure 1] FIG. 1 is a schematic diagram illustrating the mechanism by which blood flow increases due to transdermal absorption of bicarbonate ions. [Diagram 2] This is a graph showing the relationship between the weight ratio of citric acid to sodium bicarbonate in a bicarbonate bath additive according to one embodiment of the present invention and blood flow volume when bathing in water containing the bicarbonate bath additive. [Diagram 3] FIG. 1 is a graph showing the relationship between the weight ratio of sodium L-ascorbate to a bicarbonate bath agent according to one embodiment of the present invention and the amount of blood flow when bathing in water containing the bicarbonate bath agent dissolved therein. [Figure 4] This is a graph showing the relationship between the weight ratio of PEG6000 to sodium bicarbonate in a bicarbonate bath additive according to one embodiment of the present invention and the blood flow rate when bathing in water containing the bicarbonate bath additive. [Diagram 5] FIG. 1 is a graph showing the relationship between tablet hardness of a bicarbonate bath additive according to one embodiment of the present invention and blood flow rate when bathing in water containing the bicarbonate bath additive. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0018] As shown in the prior art, various lifestyle-related diseases are caused by a cold body. A cold body is the result of a prolonged stressful state in which the sympathetic nervous system is dominant. When the body is warmed up, the state changes to a parasympathetic nervous system dominant state, the balance of the autonomic nervous system improves, digestive symptoms, allergy symptoms such as atopy, and mental disorders improve, and the self-healing ability and autoimmunity are enhanced, leading to recovery from disorders and illnesses. A bicarbonate bath is known as a method for improving a cold body. In a bicarbonate bath, carbon dioxide is generated by a neutralization reaction between bicarbonate salts (sodium bicarbonate, potassium bicarbonate) that constitute bicarbonate bath additives and organic acids, and NO is produced in the vascular endothelium through transdermal absorption of bicarbonate ions, which promotes blood flow and raises body temperature.

[0019] This section explains the percutaneous absorption of bicarbonate ions. Generally, carbon dioxide dissolved in water exists as dissolved inorganic carbon, but this dissolved inorganic carbon exists in three forms due to bicarbonate equilibrium, and it is said that the form changes depending on the pH of the solution. It is known that the ratio of the three types of dissolved inorganic carbon depending on the pH is such that in the region where the pH of the solution is weakly acidic or lower, the proportion of bicarbonate ions is low and the proportion of carbonic acid is high, in the neutral to weakly alkaline region, the proportion of bicarbonate ions is highest, and in the alkaline region, the bicarbonate ions are low and the carbonate ions are high, symmetrically.

[0020] In addition, carbon dioxide is said to migrate from the skin surface to the capillaries via an accessory organ pathway that passes through the pores and sweat glands of the skin. Since the pH range of blood coincides with the pH range in which bicarbonate ions are present at their highest concentration, the inventors of the present application focused on the possibility that much of the carbon dioxide that migrates from the skin into the blood may exert physiological activity as bicarbonate ions and have beneficial effects on the living body, and investigated the effects of bicarbonate ions on the living body (see non-patent document 1).

[0021] As a result, in vivo tests showed a significant increase in blood flow in mice compared to the control group, and a tendency for an increase in the amount of bicarbonate ions in the blood and NO production via phosphorylation of endothelial nitric oxide synthase in peripheral blood vessels was observed. Furthermore, in in vitro tests using human umbilical artery endothelial cells, the presence of neutral bicarbonate ion water promoted phosphorylation of endothelial nitric oxide synthase and increased NO production, and the reactive oxygen species scavenging activity of neutral bicarbonate ion water was significantly higher than that of the control. In addition, a double-blind randomized controlled study conducted on middle-aged men and women with subjective symptoms of chilliness showed that neutral bicarbonate ion water had the effect of increasing body temperature and improving chilliness symptoms and sleep quality.

[0022] These findings demonstrate that bicarbonate ions, when absorbed percutaneously, phosphorylate endothelial nitric oxide synthase through their direct action on the vascular endothelium, thereby promoting blood flow by increasing NO production, suggesting their usefulness in improving various clinical symptoms in the cardiovascular field associated with poor circulation.

[0023] In order to efficiently absorb bicarbonate ions percutaneously, it is important that the pH of the aqueous solution after the bath additive has dissolved is neutral and that the bicarbonate ions in the bath water are highly concentrated. Therefore, the inventors of the present application have invented a method of manufacturing tablets that have a certain degree of hardness and a certain size by compression molding in the presence of polyethylene glycol using an organic acid as a compound that undergoes a neutralizing reaction with bicarbonate (sodium bicarbonate, potassium bicarbonate) (Patent Documents 1 to 3).

[0024] In bicarbonate bath additives produced by these methods, a neutralization reaction occurs vigorously and efficiently, and by continuously releasing the smallest possible carbon dioxide bubbles for a certain period of time, most of the generated carbon dioxide can be dissolved in the water without escaping into the air. In addition, by designing the pH to be neutral immediately after dissolution, the bicarbonate ions in the water become highly concentrated, and by making the pH neutral, the carbon dioxide that comes into contact with the skin easily becomes bicarbonate ions, which combine with the bicarbonate ions that are naturally present to form a high concentration of bicarbonate ions, allowing more bicarbonate ions to be absorbed into the blood vessels from the skin.

[0025] A bicarbonate bath using such bicarbonate bath additives can increase blood flow and raise body temperature, but in order to sufficiently increase the bicarbonate ion concentration in the water and maintain that state for a long time, as well as effectively remove residual chlorine in tap water, expand the capillaries to twice their size, and instantly increase blood flow (especially to more than five times the level needed to raise body temperature and improve chilliness), it is necessary to appropriately select the materials that make up the bicarbonate bath additive, appropriately set the weight ratio of those materials, and furthermore, make the hardness of the tablets compressed from those materials above a specified value.

[0026] Therefore, in the present application, the materials of the bicarbonate bath agent are set to bicarbonate (sodium hydrogen carbonate), organic acid (citric acid, succinic acid, fumaric acid, malic acid), chlorine remover (L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate), and lubricant (alkanesulfonate having 6 to 18 carbon atoms, olefinsulfonate, sucrose fatty acid ester). Based on the experimental results described below, the weight ratio of the organic acid to the bicarbonate is set to 1 / 8 to 2 / 7, the weight ratio of the chlorine remover to the bicarbonate bath agent is set to 1 / 1500 to 1 / 30, and the material is compression molded so that the hardness of the bicarbonate bath agent is 20 kgf or more. Furthermore, a granulation promoter (polyethylene glycol, etc.) is added to the above materials, and the weight ratio of the granulation promoter to the bicarbonate is set to 1 / 50 to 1 / 8.

[0027] By using these materials, weight ratios, and hardness settings, the water with the bicarbonate bath additives dissolved in it becomes neutral, generating a high concentration of bicarbonate ions, which in turn secretes nitric oxide (NO) into the endothelium of the blood vessels, causing the capillaries to expand to twice their size and instantly increasing blood flow by more than five times. This raises body temperature and improves the chilliness of the body that is the cause of lifestyle-related diseases. EXAMPLES

[0028] In order to explain the above-mentioned embodiment of the present invention in more detail, bicarbonate bath additives and a manufacturing method thereof according to an embodiment of the present invention will be described with reference to Figs. 1 to 5. Fig. 1 is a schematic diagram for explaining the mechanism of increase in blood flow rate due to percutaneous absorption of bicarbonate ions. Fig. 2 is a diagram showing the relationship between the weight ratio of citric acid to sodium bicarbonate in the bicarbonate bath additive and the blood flow rate when taking a bath in water containing the bicarbonate bath additive. Fig. 3 is a diagram showing the relationship between the weight ratio of L-sodium ascorbate to the bicarbonate bath additive and the blood flow rate when taking a bath in water containing the bicarbonate bath additive. Fig. 4 is a diagram showing the relationship between the weight ratio of PEG6000 to sodium bicarbonate in the bicarbonate bath additive and the blood flow rate when taking a bath in water containing the bicarbonate bath additive. Fig. 5 is a diagram showing the relationship between the tablet hardness of the bicarbonate bath additive and the blood flow rate when taking a bath in water containing the bicarbonate bath additive.

[0029] FIG. 1 shows a schematic diagram of the structure of a human blood vessel, in which the dermis / subcutaneous adipose tissue 2 is located inside the epidermis 1, and the blood vessel 5 is located inside the dermis / subcutaneous adipose tissue 2. The blood vessel 5 is composed of a blood vessel wall 6 having smooth muscle 7 and vascular endothelial cells 8 on the inside of the blood vessel wall 6, and the inside of the vascular endothelial cells 8 is the inside of the blood vessel 9. When a person bathes in hot water containing dissolved bicarbonate ions, as shown in FIG. 1, the bicarbonate ions penetrate into the blood vessel 9 through sweat pores 4 and the like, phosphorylating endothelial nitric oxide synthase (eNOS) present in the vascular endothelial cells 8 (P-eNOS), which acts on L-arginine (L-Al) to generate nitric oxide (NO). The generated NO is converted to cyclic guainosine monophosphate (cGMP) by guanosine triphosphate (GTP) via guanylate cyclase enzyme (sGC). The cyclic guainosine monophosphate (cGMP) relaxes the smooth muscle 7 in the blood vessel wall 6, which results in the expansion of the blood vessel 5 and an increase in blood flow.

[0030] Therefore, by increasing the concentration of bicarbonate ions in the bath water using bicarbonate bath additives that dissolve the bicarbonate ions in the bath water to a neutral pH level, the secretion of nitric oxide into the vascular endothelium becomes more active due to the effects of the bicarbonate ions described above, and blood flow can be dramatically improved. Below, we will explain the bicarbonate bath additives that provide the effects of bicarbonate ions.

[0031] The bicarbonate bath additive of this embodiment is made by mixing bicarbonate, organic acid, chlorine neutralizing compound, and lubricant, and compressing the mixture. If necessary, materials such as water-soluble polymers (hereinafter referred to as granulation promoters) are added to improve tablet formability and solubility in hot water, and the mixture is compressed.

[0032] As the bicarbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, etc. can be used, but sodium hydrogen carbonate is particularly preferred. This sodium hydrogen carbonate (sodium bicarbonate or baking soda) plays a role as a foaming agent, and when it dissolves in hot water together with an organic acid, it foams carbon dioxide through a neutralization reaction, dissociates into bicarbonate ions and hydrogen ions depending on the pH of the dissolution water, and dissolves in the water. This bicarbonate ion exerts the ability to clean mineral sebum dirt in pores, which is the source of so-called odor. The content of bicarbonate in bicarbonate bath additives is specified in relation to other components. If the content is less than the specified amount, the pH when dissolved in hot water will not reach the specified value, and the amount of bicarbonate ions dissolved in hot water will be significantly reduced. On the other hand, if the content exceeds the specified amount, the foaming of carbon dioxide gas will be significantly reduced.

[0033] The organic acid neutralizes bicarbonate and produces carbon dioxide gas effervescence, and when dissolved in hot water, it also has a skin cleansing effect and a skin softening effect. Citric acid, succinic acid, fumaric acid, malic acid, etc. can be used as the organic acid, but citric acid is particularly preferred. When citric acid is used, the neutralization reaction occurs more effectively than when other organic acids are used. The content of the organic acid is specified in relation to the other components as described above. If the content is less than the specified amount, the amount of carbon dioxide gas effervescence during the dissolution of the tablet decreases, the amount of bicarbonate ions dissolved decreases, and the blood flow enhancement effect decreases. On the other hand, if the content exceeds the specified amount, the amount of carbon dioxide gas effervescence increases, but the diameter of the bubbles increases, making it difficult to neutralize the gas, and the amount of bicarbonate ions dissolved decreases.

[0034] As the chlorine neutralizing compound, L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate, etc. can be used, with L-ascorbate being particularly preferred. As L-ascorbic acid, any known compound can be used without any particular restrictions. As the salt, sodium salt and calcium salt can be mentioned, with sodium salt (sodium L-ascorbate) being particularly preferred. L-ascorbic acid is widely known as vitamin C, and when added to tap water, it can remove chlorine contained in tap water through the reactions shown in the following reaction formulas 1 and 2. In addition, reducing agents such as sodium thiosulfate, thiosulfate, sulfite, and tea catechin can also neutralize and detoxify chlorine through a similar reaction.

[0035] [Reaction 1] C6H8O6 + NaClO → C6H6O6 + H2O + NaCl (Reaction in which vitamin C reduces and removes sodium hypochlorite, which is added for primary sterilization)

[0036] [Reaction 2] C6H8O6 + Cl2 → C6H6O6 + 2HCl (Reaction in which chlorine added to maintain chlorine is removed by vitamin C)

[0037] When ascorbic acid dissolves in tap water through the reactions of reaction formulas 1 and 2, the chlorine contained in the tap water is removed. This prevents the occurrence of problems such as "oxidation, aging, and dandruff" that residual chlorine causes to the skin. In addition, ascorbic acid itself has the effects of increasing skin firmness, preventing fine wrinkles, beautifying the skin, whitening, and anti-aging. As shown in reaction formula 2, a small amount of hydrochloric acid is generated when chlorine is removed, but the pH of the dissolved water is buffered by the buffer effect of bicarbonate ions and organic acids, so the pH of shower water and bath water does not become acidic, and the pH of tap water is stable. The content of this chlorine neutralizing compound is specified in relation to the amount of hot water per tablet of bicarbonate bath additive. If the content is less than the specified amount, the chlorine contained in tap water cannot be sufficiently removed. On the other hand, even if the content is added to a level greater than the specified amount, there is no chlorine to be removed, and the chlorine neutralizing compound is wasted.

[0038] The lubricant is a substance that improves the flowability, compressibility, etc. of a powder. As the lubricant, at least one selected from an alkane sulfonate having 6 to 18 carbon atoms, an olefin sulfonate, and a sucrose fatty acid ester can be used, and in particular, the alkane sulfonate having 6 to 18 carbon atoms and / or the olefin sulfonate is preferably at least one selected from sodium alkane sulfonate having 14 to 18 carbon atoms, sodium tetradecene sulfonate, and sodium normal octane sulfonate.

[0039] The granulation promoter plays the role of compressing and molding materials such as bicarbonate, organic acid, and chlorine neutralizing compound to produce tablets, of making tablets more soluble in hot water, and of dissolving carbon dioxide gas components as bicarbonate ions to the maximum extent when the tablets are dissolved in hot water. Polyethylene glycol (PEG) can be used as the granulation promoter, and PEG6000 is particularly preferred. In the manufacturing process, polyethylene glycol is used with solvents such as ethylene oxide, which is a carcinogenic substance, and 1,4-dioxane, which is suspected to be carcinogenic, and there is concern that it may be contaminated by these solvents. In addition, polyethylene glycol is concerned about causing allergies because it remains in the body for a long time. As an alternative to polyethylene glycol, for example, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, magnesium sulfate, sodium sulfate, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, dextran, etc. can be used. The content of the granulation promoter is specified in relation to the other components as described above. If the content is less than the specified amount, the diameter of the carbon dioxide bubbles will be large and the foaming time will be short, and the amount of carbon dioxide that dissolves in the hot water will not be increased. On the other hand, if the content exceeds the specified amount, the amount of bubbles generated will be suppressed, and similarly, the amount of carbon dioxide that dissolves in the hot water will be reduced.

[0040] Next, a method for producing a bicarbonate bath additive using these materials will be described.

[0041] Methods for producing bicarbonate bath additives include: (1) preparing a granulated product of bicarbonate (coating the bicarbonate with a granulation aid, if necessary, to prepare granulated product) and mixing the granulated product with a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant; (2) preparing a granulated product of an organic acid (coating the organic acid with a granulation aid, if necessary, to prepare granulated product) and mixing the granulated product with a mixture of bicarbonate, a chlorine neutralizing compound, and a lubricant; and (3) preparing a granulated product of bicarbonate (coating the bicarbonate with a granulation aid, if necessary, to prepare granulated product) and a granulated product of an organic acid (coating the organic acid with a granulation aid, if necessary, to prepare granulated product) and mixing the chlorine neutralizing compound and a lubricant with the granulated product.

[0042] Either method can be used to produce a bicarbonate bath additive that exerts the effects of bicarbonate ions, but method (1) can maximize the amount of carbon dioxide gas dissolved in the hot water by foaming micro-sized bubbles for a long period of time, and can also greatly reduce the number of steps, so the method for producing the bicarbonate bath additive in this embodiment is preferably method (1), that is, a method in which a granulated product of bicarbonate is produced (here, the granulated product is produced by coating the bicarbonate with a granulation promoter) and a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant is mixed with the granulated product. The following explanation will be based on this method.

[0043] First, the bicarbonate is coated with a granulation promoter to prepare a granule. In this example, sodium hydrogen carbonate is used as the bicarbonate and PEG6000 is used as the granulation promoter.

[0044] When bicarbonate is granulated in a fluidized bed to obtain a granulated product, the hardness of the tablet can be significantly increased by using a mechanical fluidized bed granulator that does not substantially use air for stirring. In a mechanical fluidized bed granulator, air is not used for stirring, and the powder is fluidized using mechanical blades such as a propeller, so that moisture brought in from humid air during granulation is not absorbed during granulation, and it is also possible to create a vacuum with a vacuum pump during granulation. As a result, granulation can be performed with a reduced amount of granulation promoter, which has the effect of making the diameter of the foaming bubbles smaller while making the neutralization reaction more active, and is preferably used because it can produce tablets with high hardness.

[0045] A mechanical fluidized bed granulator that does not substantially use air for agitation is a mixer that has a plough-like shovel inside a horizontal drum to generate centrifugal diffusion and vortex flow effects, resulting in three-dimensional fluidization. For example, models manufactured by Deutsche Loedige AG or Matsuzaka Giken Co., Ltd. are sold on the market.

[0046] It is more preferable that the present granulator is equipped with a vacuum pump for reducing the pressure. That is, by reducing the pressure during cooling and operating so as to remove as much moisture as possible, the effect of the present invention can be improved. Furthermore, it is preferable that the present granulator is equipped with a chopper for preventing the granulated granules from becoming coarse particles during cooling. That is, by operating the chopper during cooling to regulate the size, the effect of reducing the diameter of the carbon dioxide gas bubbles of the present invention to micro-size can be achieved.

[0047] Next, a mixture of organic acid, chlorine neutralizing compound, and lubricant is prepared. In this embodiment, citric acid is used as the organic acid, sodium L-ascorbate is used as the chlorine neutralizing compound, and sodium tetradecene sulfonate and sodium octanesulfonate are used as the lubricants. If the mixture of organic acid, chlorine neutralizing compound, and lubricant is not granulated, it is not necessary to add a granulation promoter, but a granulation promoter may be added to improve tableting properties.

[0048] Next, the mixture (organic acid, chlorine neutralizing compound, and lubricant) is mixed with the granulated material (bicarbonate and granulation promoter) and compressed to produce tablets. A known compression molding machine can be used for the compression molding to produce tablets, but for example, a hydraulic press, a single punch tablet press, a rotary tablet press, a briquetting machine, etc. can also be used.

[0049] The size of the punch used in the tablet press or the like is preferably 10 mm or more in diameter if the punch is circular, and preferably 10 mm or more in diameter if the punch is triangular or rectangular, when converted into a circular punch. The same applies to the thickness of the punch. When making a circular tablet, the diameter of the tablet is preferably 10 mm or more, and the thickness is also preferably 10 mm or more. When making a triangular or rectangular tablet, the diameter and thickness are each preferably 10 mm or more when converted into a circular tablet. The tablet does not necessarily have to be circular with a flat surface, and there is no restriction on the shape as long as it is a solid object of 10 mm or more, whether it is elliptical, tablet, or spherical.

[0050] In addition, during compression molding, the tablet hardness (breaking strength and Vickers hardness) must be at or above a specified value. The higher the hardness, the more effectively carbon dioxide gas is generated in the tablet, and the more efficiently the carbon dioxide gas dissolves in the water, resulting in finer bubbles and more favorable results. The diametric breaking strength (kgf) can be measured using the New Speed ​​Checker TS75NL digital tablet hardness tester manufactured by Okada Seiko Co., Ltd. The Vickers hardness (Hv, kgf / mm 2 ) can be measured using a micro Vickers hardness tester, Mitutoyo HM-221, which is a type of hardness tester.

[0051] The above is the basic composition and manufacturing method of the bicarbonate bath agent, but anhydrides such as anhydrous sodium carbonate, anhydrous potassium carbonate, anhydrous calcium carbonate, and anhydrous magnesium carbonate may be added to the bicarbonate bath agent. By adding an anhydride, the bubble size of the carbon dioxide gas can be made optimally small while the foaming amount can be made larger and last for a long time, and the above effect can be particularly notable when anhydrous sodium carbonate is added as the anhydride. The anhydride can be added at any step before compression molding, such as the step of preparing a granulated product or the step of mixing the granulated product with a mixture, but it is preferable to add the anhydride at the stage of mixing the mixture of an organic acid, a chlorine neutralizing compound, and a lubricant with the granulated product of bicarbonate. In particular, it is most preferable to add the organic acid, the chlorine neutralizing compound, the lubricant, and the anhydride simultaneously after cooling the granulated product, mix them, and immediately tablet them. If the amount of the anhydride is too large, the amount of foaming bubbles will be reduced, while if the amount is too small, carbon dioxide gas will be generated in the hot water intensively, which is not preferable.

[0052] In addition, bicarbonate bath additives can use a release agent for tablet molding. As this release agent, sucrose, magnesium stearate, etc. are generally used, and magnesium stearate is the most preferable because it can stably and continuously compress and mold tablets at high speed. Furthermore, bicarbonate bath additives can be mixed with other ingredients as necessary. As other ingredients, health ingredients such as hyaluronic acid, fragrances, colorants, surfactants, etc. can be mentioned.

[0053] Next, the following experiment was conducted to determine the optimal weight ratio of each material of the bicarbonate bath additive and tablet hardness. As described above, when bicarbonate ions are absorbed percutaneously, nitric oxide (NO) is generated in blood vessels, which expand blood vessels at once to increase blood flow. Therefore, by measuring the blood flow rate of the subject while bathing, the optimal values ​​of the weight ratio of organic acid (citric acid) to bicarbonate (sodium bicarbonate), the weight ratio of chlorine neutralizing compound (sodium L-ascorbate) to bicarbonate bath additive, the weight ratio of granulation promoter (PEG6000) to bicarbonate (sodium bicarbonate), and tablet hardness were investigated.

[0054] This blood flow was measured using a non-contact laser Doppler blood flow meter (ALF21N manufactured by Advance Co., Ltd.) by converting the reflected light from the tissue when irradiating the living tissue with laser light into an electrical signal and processing it. The measurement was performed at the dorsal part of the hand, which corresponds to the so-called "Hegu" point, and a measurement glove was attached to the skin. The unit of blood flow is mL / min / 100g-tissue, but here it is expressed as a multiple of the value before bathing, and the average value of the data collected by the subject over 5 days was used.

[0055] In addition, the bicarbonate bath additives used in the experiments had a basic composition per tablet (15g) of bicarbonate bath additive: 11.10g sodium bicarbonate as bicarbonate, 2.3g citric acid as an organic acid, 0.10g sodium L-ascorbate as a chlorine neutralizing compound, 0.01g sodium tetradecenesulfonate and 0.07g sodium octanesulfonate as lubricants, 0.82g PEG6000 as a granulation promoter, and 0.6g sodium carbonate as anhydrous. In experiment 1, the weight ratio of citric acid to sodium bicarbonate was changed, in experiment 2 the weight ratio of sodium L-ascorbate to sodium bicarbonate was changed, in experiment 3 the weight ratio of PEG6000 to sodium bicarbonate was changed, and in experiment 4 the tablet hardness was changed by adjusting the tableting pressure and moisture content.

[0056] [Experiment 1] First, 180 L of water was poured into the bathtub and the bathing temperature was adjusted to 38°C, and three tablets of bicarbonate bath additives (15 g) with varying weight ratios of citric acid to sodium bicarbonate were added into the bath, and the blood flow rate was measured after 10 subjects (healthy men and women aged 20 to 60 years) bathed for 30 minutes. The results are shown in Table 1 and Figure 2. Note that the blood flow rate is shown as a ratio (multiple) of the blood flow rate before bathing.

[0057] [Table 1]

[0058] FIG. 2 shows the correlation between the citric acid weight ratio (citric acid weight / sodium bicarbonate weight) and blood flow rate. By bathing in hot water in which the bicarbonate bath additive of this embodiment is added and bicarbonate ion concentration is generated, the bicarbonate ions are absorbed transdermally and nitric oxide is generated, and cyclic guainosine phosphate generated from nitric oxide relaxes smooth muscles and expands blood vessels, thereby increasing blood flow rate. However, as shown in FIG. 2, when the weight ratio of citric acid to sodium bicarbonate is changed, the concentration of bicarbonate ions generated in the hot water changes and the degree of increase in blood flow rate changes. Specifically, as the weight ratio of citric acid increases, the bicarbonate ion concentration increases and the increase in blood flow rate increases, but when the weight ratio of citric acid exceeds a certain value, the bicarbonate ion concentration does not increase and the increase in blood flow rate decreases. In this experiment, when the weight ratio of citric acid was 0.131, the blood flow rate was about 5.9 times that before bathing, when the weight ratio of citric acid was 0.207, the blood flow rate was about 6.2 times that before bathing, when the weight ratio of citric acid was 0.272, the blood flow rate increased to about 6.1 times that before bathing, and then when the weight ratio of citric acid was 0.305, the blood flow rate increased to about 5.3 times that before bathing. If the blood flow rate increases by 5 times or more, the body temperature can be raised to a level that can improve the chill of the body, so it can be said that the weight ratio of citric acid to sodium bicarbonate is in the preferable range of 1 / 8 to 2 / 7, where the blood flow rate increases by 5 times or more.

[0059] [Experiment 2] Next, 180 L of hot water was poured into the bathtub and the bath temperature was adjusted to 38°C, and three tablets of bicarbonate bath additives (15 g) with varying amounts of sodium L-ascorbate added per tablet were added, and 10 subjects (healthy men and women aged 20 to 60 years) were allowed to bathe for 30 minutes, after which the blood flow was measured. The results are shown in Table 2 and Figure 3. The blood flow rate is shown as a ratio (multiple) of the blood flow rate before bathing.

[0060] [Table 2]

[0061] FIG. 3 shows the correlation between the weight ratio of sodium L-ascorbate (weight of sodium L-ascorbate / weight of tablet) and blood flow rate, and the weight ratio of sodium L-ascorbate is shown on a logarithmic scale. By adding the bicarbonate bath additive of this embodiment, the residual chlorine in the bath water containing dissolved bicarbonate ions is removed, resulting in a state of parasympathetic dominance, which in turn switches on the homeostatic function of the body, secretes nitric oxide into the capillary endothelium, and expands the blood vessels, thereby increasing the blood flow rate. Specifically, as the weight ratio of sodium L-ascorbate increases, the residual chlorine is removed and the increase in blood flow rate increases, but when the weight ratio of sodium L-ascorbate exceeds a certain value, the residual chlorine in the bath water disappears, and the increase in blood flow rate decreases. In this experiment, when the weight ratio of sodium L-ascorbate was 0.0008 and 0.0033, the blood flow increased to about 6.0 times that before bathing, when the weight ratio of sodium L-ascorbate was 0.0066 and 0.0303, the blood flow increased to about 6.2 times that before bathing, and then when the weight ratio of sodium L-ascorbate was 0.047, the blood flow increased to about 5.3 times that before bathing. If the blood flow increases by 5 times or more, the body temperature can be raised to a level that can improve chilliness, so it can be said that the weight ratio of sodium L-ascorbate is in the preferable range of 1 / 1500 to 1 / 30, where the blood flow increases by 5 times or more.

[0062] [Experiment 3] Next, 180 L of water was poured into the bathtub, the bath temperature was adjusted to 38°C, and three tablets of bicarbonate bath additives (15 g) with varying weight ratios of PEG6000 to sodium bicarbonate were added, and 10 subjects (healthy men and women aged 20 to 60 years) were allowed to bathe for 30 minutes, at which point their blood flow was measured. The results are shown in Table 3 and Figure 4. The blood flow rate is shown as a ratio (multiple) of the blood flow rate before bathing.

[0063] [Table 3]

[0064] Figure 4 shows the correlation between the weight ratio of PEG6000 (PEG6000 weight / sodium bicarbonate weight) and blood flow. As shown in Figure 4, when the weight ratio of PEG6000 to sodium bicarbonate is changed, the form of the carbon dioxide gas bubbles changes and the degree of increase in blood flow changes. Specifically, as the weight ratio of PEG6000 increases, the carbon dioxide gas bubbles become smaller, the bicarbonate ion concentration increases, and the increase in blood flow becomes larger. However, if the weight ratio of PEG6000 becomes too large, the amount of carbon dioxide gas bubbles is suppressed and the bicarbonate ion concentration decreases, so the increase in blood flow becomes smaller. In this experiment, when the weight ratio of PEG6000 was 0.028, the blood flow was about 6.0 times that before bathing; when the weight ratio of PEG6000 was 0.073, the blood flow was about 6.2 times that before bathing; when the weight ratio of PEG6000 was 0.118, the blood flow increased to about 6.0 times that before bathing. Subsequently, when the weight ratio of PEG6000 was 0.135, the blood flow was about 5.1 times that before bathing. Since the body temperature can be raised to a level that can improve the body's coldness if the blood flow increases by 5 times or more, it can be said that the weight ratio of PEG6000 is preferably in the range of 1 / 50 to 1 / 8 when the blood flow increases by 5 times or more.

[0065] [Experiment 4] Next, 180 L of hot water was put into the bathtub and the bathing temperature was adjusted to 38°C. Three tablets (15 g) of a sodium bicarbonate bath agent with the tablet hardness changed by adjusting the tableting pressure and / or water content were put into it, and the blood flow of 10 subjects (healthy men and women aged 20 or above and 60 or below) during a 30-minute bath was measured. The results are shown in Table 4 and Figure 5. The blood flow indicates the ratio (multiple) to the blood flow before bathing. Also, the tablet strength (kgf) was measured using a digital tablet hardness tester New Speed Checker TS75NL manufactured by Okada Seiko Co., Ltd.

[0066]

Table 4

[0067] FIG. 5 shows the correlation between tablet hardness and blood flow rate. As shown in FIG. 5, when the tablet hardness is changed by adjusting the tableting pressure or water content, the shape of the carbon dioxide bubbles changes and the degree of increase in blood flow rate changes. Specifically, as the tablet hardness increases, the carbon dioxide bubbles become smaller, the bicarbonate ion concentration increases, and the increase in blood flow rate increases. In this experiment, when the tablet hardness was 20 kgf, the blood flow rate was about 5.8 times that before bathing, and when the tablet hardness was 40 kgf or more, the blood flow rate was about 6.2 times that before bathing. If the blood flow rate increases by 5 times or more, the body temperature can be raised to a level that can improve the chill of the body, so it can be said that the tablet hardness of 20 kgf or more, where the blood flow rate increases by 5 times or more, is the preferable range.

[0068] As explained above, by using a bicarbonate bath additive containing bicarbonate (sodium hydrogen carbonate), organic acid (citric acid, succinic acid, fumaric acid, malic acid), chlorine neutralizing compound (L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate), and lubricant (alkanesulfonate having 6 to 18 carbon atoms, olefin sulfonate, sucrose fatty acid ester), and with the weight ratio of organic acid and chlorine neutralizing compound and the tablet hardness specified within a predetermined range, it is possible to expand capillaries to twice their size and increase blood flow by more than five times in one go.

[0069] In particular, by setting the weight ratio of the organic acid to the bicarbonate to 1 / 8 to 2 / 7, the weight ratio of the chlorine neutralizing compound to the tablet to 1 / 1500 to 1 / 30, and the tablet hardness to 20 kgf or more, using citric acid as the organic acid, using sodium L-ascorbate as the chlorine neutralizing compound, using at least one selected from sodium alkanesulfonate having 14 to 18 carbon atoms, sodium tetradecenesulfonate, and sodium normal octanesulfonate as the lubricant instead of alkanesulfonate having 6 to 18 carbon atoms, sodium tetradecenesulfonate, and sodium normal octanesulfonate, and adding a granulation promoter (PEG6000) and setting the weight ratio of the granulation promoter to sodium bicarbonate to 1 / 50 to 1 / 8, the concentration of bicarbonate ions generated in the bath water in which the bicarbonate bath additive has been dissolved can be maximized, and blood flow can be maximized, and as a result, body temperature can be raised to a level that can improve the chill in the body that is the cause of lifestyle-related diseases.

[0070] The present invention is not limited to the above-described embodiment, and the configuration can be modified as appropriate without departing from the spirit of the present invention.

[0071] For example, in the above examples, a method was described in which a bicarbonate was coated with a granulation promoter to produce a granulated product, and then a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant was mixed. However, the manufacturing method can be modified as appropriate, and for example, a method in which an organic acid is coated with a granulation promoter to produce a granulated product, and then a mixture of a bicarbonate, a chlorine neutralizing compound, and a lubricant was mixed with the granulated product, can also be used. [Industrial Applicability]

[0072] INDUSTRIAL APPLICABILITY The present invention can be used for bicarbonate bath additives and methods for producing the same. [Explanation of symbols]

[0073] 1 epidermis 2 Dermis / subcutaneous adipose tissue 3 Pores 4. Sweat pores 5 blood vessels 6 Blood vessel wall 7 Smooth Muscle 8 Vascular endothelial cells 9 Intravascular

Claims

1. A bicarbonate bath agent comprising a tablet compressed from a material containing a bicarbonate, an organic acid, a chlorine neutralizing compound, and a lubricant, The bicarbonate is sodium hydrogen carbonate, The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; The lubricant is at least one selected from the group consisting of alkanesulfonates having 6 to 18 carbon atoms, olefinsulfonates, and sucrose fatty acid esters; the weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7; The weight ratio of the chlorine neutralizing compound to the tablet is 1 / 1500 to 1 / 30; The hardness of the tablet is 20 kgf or more. A bicarbonate bath additive characterized by:

2. The organic acid is citric acid.

2. The bicarbonate bath additive according to claim 1.

3. The chlorine neutralizing compound is sodium L-ascorbate.

2. The bicarbonate bath additive according to claim 1.

4. The alkane sulfonate having 6 to 18 carbon atoms and / or the olefin sulfonate of the lubricant is at least one selected from sodium alkane sulfonate having 14 to 18 carbon atoms, sodium tetradecene sulfonate, and sodium normal octane sulfonate.

2. The bicarbonate bath additive according to claim 1.

5. The material comprises a granulation enhancer; the granulation promoter is at least one selected from polyethylene glycol, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, magnesium sulfate, sodium sulfate, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; The weight ratio of the granulation enhancer to the bicarbonate is 1 / 50 to 1 / 8.

5. The bicarbonate bath additive according to claim 1 .

6. The granulation enhancer is PEG 6000.

6. The bicarbonate bath additive according to claim 5.

7. A method for producing a bicarbonate bath agent comprising a tablet containing a bicarbonate salt, an organic acid, a chlorine neutralizing compound, and a lubricant, comprising: The bicarbonate is sodium hydrogen carbonate, The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; The lubricant is at least one selected from the group consisting of alkanesulfonates having 6 to 18 carbon atoms, olefinsulfonates, and sucrose fatty acid esters; The weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7; The weight ratio of the chlorine neutralizing compound to the tablet is 1 / 1500 to 1 / 30, A granulated product of the bicarbonate is prepared, and the mixture of the organic acid, the chlorine neutralizing compound, and the lubricant is mixed with the granulated product, and then the mixture is compressed and molded to prepare the tablet having a hardness of 20 kgf or more. A method for producing a bicarbonate bath additive, comprising the steps of:

8. The organic acid is citric acid. A method for producing the bicarbonate bath additive according to claim 7.

9. The chlorine neutralizing compound is sodium L-ascorbate. A method for producing the bicarbonate bath additive according to claim 7.

10. The alkane sulfonate having 6 to 18 carbon atoms and / or the olefin sulfonate of the lubricant is at least one selected from sodium alkane sulfonate having 14 to 18 carbon atoms, sodium tetradecene sulfonate, and sodium normal octane sulfonate. A method for producing the bicarbonate bath additive according to claim 7.

11. The tablet comprises a granulation enhancer, the granulation promoter is at least one selected from polyethylene glycol, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, magnesium sulfate, sodium sulfate, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; The weight ratio of the granulation promoter to the bicarbonate is 1 / 50 to 1 / 8, coating the bicarbonate with the granulation aid to produce the granulation. A method for producing a bicarbonate bath additive according to any one of claims 7 to 10.

12. The granulation enhancer is PEG 6000. A method for producing a bicarbonate bath additive according to claim 11.

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