Compositions comprising natural polymers and one or more (BIO)-alkanediols
By adding 1,2-heptanediol or 2,3-heptanediol to natural polymer-based cosmetics and pharmaceuticals, the microbial load is reduced, improving storage stability and potentially eliminating the need for additional antimicrobial agents.
Patent Information
- Application Number
- JP2025034858
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2020-12-09
- Filing Date
- 2025-03-05
- Publication Date
- 2025-06-03
AI Technical Summary
Natural polymers used in cosmetics and pharmaceuticals often have high microbial loads, making it challenging to store these products and requiring additional antimicrobial agents or sterilization steps, which are costly and undesirable.
Incorporating an effective amount of 1,2-heptanediol or 2,3-heptanediol, or a mixture of specific alkanediols into cosmetic or pharmaceutical compositions containing natural polymers to reduce the microbial load and achieve preservable microbial stability.
The use of these alkanediols synergistically reduces the microbial load in natural polymer-based products, enhancing their storage stability and shelf life while potentially reducing the need for antimicrobial agents.
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Figure 2025084990000001_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to cosmetics, pharmaceuticals, preferably dermatological compositions or home care products, or personal care cosmetics, comprising or consisting of a natural polymer and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol, or a specific alkanediol, or a mixture of two or more different specific alkanediols, and their use as pharmaceuticals for animal rearing or home care. Further, the present invention relates to the use of 1 ,2-heptanediol and / or 2,3-heptanediol, or a specific alkanediol, or a mixture of two or more different specific alkanediols, in an effective amount to reduce the antimicrobial load of a natural polymer and / or as an antimicrobial substitute. Finally, the present invention relates to a method for reducing the antimicrobial load of a cosmetic or pharmaceutical composition or home care product comprising a natural polymer.
Background Art
[0002] Cosmetics, personal care, dermatological pharmaceuticals or home care products are complex mixtures intended to be applied to the outer parts of the human body or for washing, cleaning and laundering purposes. The long list of ingredients includes polymers, either natural or synthetic. A wide range of natural and synthetic polymers are widely used in a broad spectrum of cosmetics and personal care products to achieve diverse functions such as thickening, emulsification (holding of mixed ingredients together), formation of a protective film or barrier, and overall production of a product with a "smoother" or more moisturized, smoother or more pleasant feel.
[0003] Natural polymers or biopolymers have attracted great interest due to their biocompatibility, non-toxicity, renewability, and mild processing conditions. These polymers are enzymatically or non-enzymatically degradable in vivo and can be metabolized and excreted via normal physiological pathways. Furthermore, natural polymers or biopolymers are becoming more popular due to the discussion of microplastics (e.g.,
[0004] see carbomer, a sustainable polyacrylic acid polymer), as well as the increasing consumer demand for natural and biodegradable components.
[0005] A drawback of these natural polymers or biopolymers is the higher natural contamination of bacteria compared to synthetic polymers. Usually, a bacterial load of up to 1000 colony-forming units per gram of raw material is acceptable for cosmetics, but 100 colony-forming units per gram of raw material is most preferred. The natural contamination of bacteria makes it difficult to store polymer solutions or polymer-containing formulations. Especially in the preparation of cosmetic or pharmaceutical dispersions, when the surface and moisture content increase, bacterial growth is promoted. Therefore, using natural polymers challenges the above limits.
[0006] To reduce the microbial load of the formulation, antimicrobial agents or sterilization are applied. The addition of antimicrobial agents is becoming increasingly undesirable, especially for natural cosmetics, and the sterilization step causes additional production costs. Sterilization of the formulation is not very desirable because it may decompose the formulation components during heat treatment and due to the associated additional processing
[0007] Therefore, there is still a need to develop novel compositions that are safe with respect to microorganisms. The cosmetics or pharmaceutical industry is constantly investigating ingredients that can improve this negative aspect.
[0008] When investigating agents with antimicrobial activity, substances used in the cosmetics or pharmaceutical sector must be toxicologically acceptable, well tolerated by the skin, and in particular stable in commonly used cosmetics and / or pharmaceutical formulations or home care products, substantially and preferably odorless, and also inexpensive, i.e., possible to prepare using standard methods and / or starting from standard precursors. This must be taken into account.
[0009] However, on the one hand, there is no clear dependence between the chemical structures of substances and, on the other hand, their biological activity against specific microorganisms and their stability, which makes the investigation of suitable substances more difficult. Furthermore, there is no predictable relationship between antimicrobial activity, toxicological acceptability, tolerance, and the stability of substances.
[0010] Therefore, an object of the present invention is to provide cosmetics or pharmaceuticals, in particular dermatological compositions or home care products, containing or consisting of natural polymers that have a reduced microbial load and are stable, i.e., can be stored.
[0011] Another object of the present invention is a substance that can reduce the microbial load of natural polymers, i.e., in particular in cosmetics, pharmaceutical compositions, or home care products, and / or the amount of antimicrobial agents in cosmetics or pharmaceutical compositions can be reduced. To provide a substance suitable as an antimicrobial agent substitute.
[0012] Furthermore, an object of the present invention is to provide a method for reducing the microbial load in a cosmetic, pharmaceutical composition, or home care product containing a natural polymer.
[0013] Surprisingly, adding an effective amount of 1,2 - heptanediol or 2,3 - heptanediol, or a mixture containing 1,2 - heptanediol and 2,3 - heptanediol, or a specific alkanediol, or a mixture of two or more defined specific alkanediols to a cosmetic, pharmaceutical composition, or home care product containing a natural polymer synergistically reduces the microbial load therein, thereby obtaining a formulation with preservable microbial stability.
[0014] In particular, it has been found that the defined specific alkanediol mixture is particularly suitable for reducing the microbial load in a cosmetic, pharmaceutical composition, or home care product containing a natural polymer, thereby obtaining a formulation with preservable microbial stability. SUMMARY OF THE INVENTION
[0015] To address the above problems, in a first aspect, the present invention provides (a1) 1,2 - heptanediol; (b1) at least one natural polymer; and (c1) optionally, at least one active agent and / or additive for a cosmetic, pharmaceutical composition, or home care product; or (a2) 2,3 - heptanediol; (b2) at least one natural polymer; and (c2) optionally, at least one active substance and / or additive for a cosmetic, pharmaceutical composition or home care product; or (a3) a mixture comprising 1,2 - heptanediol and 2,3 - heptanediol, (b3) at least one natural polymer; and (c3) optionally, at least one active substance and / or additive for a cosmetic, pharmaceutical composition or home care product, or a cosmetic, pharmaceutical composition or home care product comprising or consisting of these is provided.
[0016] In a second aspect, the present invention (a) at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms , or a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms different from the first linear alkanediol, (b) at least one natural polymer; and (c) optionally, at least one active substance and / or additive for a cosmetic, pharmaceutical composition or home care product, or a cosmetic, pharmaceutical composition or home care product comprising or consisting of these is provided. (c) optionally, at least one active substance and / or additive for a cosmetic, pharmaceutical composition or home care product, or a cosmetic,
[0017] In a further aspect, the present invention provides the use of a cosmetic or pharmaceutical composition as a cosmetic for animal husbandry or a pharmaceutical for home care, especially for personal care of skin, hair, scalp and nails. (c) optionally, at least one active substance and / or additive for a cosmetic, pharmaceutical composition or home care product, or a cosmetic,
[0018] In a further aspect, the present invention is for reducing the antimicrobial agent loading of natural polymers and / or for use as an antimicrobial agent alternative, 1,2-heptanediol or 2,3-heptanediol, or a mixture comprising 1,2-heptanediol and 2,3-heptanediol, or at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols is provided. or 2,3-heptanediol, or a mixture comprising 1,2-heptanediol and 2,3-heptanediol, or at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols is provided. In a final aspect, the present invention provides a method for reducing the antimicrobial agent loading in a cosmetic or pharmaceutical composition or a home care product comprising a natural polymer.
Brief Description of the Drawings
[0019] FIG. is a diagram showing representative results of the microbial load in water of Polycos-N75 (0.5%) in water (A), or water added with 0.5% 1,2-pentanediol (B), 1,2-hexanediol (C) or 1,2-heptanediol (D) after storage at 40° C. for 7 days.
[0020]
Figure 1
[0021]
Figure 2
[0022]
Figure 3
[0023]
Figure 4
[0024] The present invention is set forth in the appended claims. However, the invention itself, as well as its preferred modifications, other objects and advantages will become apparent from the following detailed description in conjunction with the accompanying examples and figures.
[0025] In a first aspect, the invention relates to: (a1) 1,2-heptanediol; (b2) at least one natural polymer; and (c3) optionally, a cosmetic, or a pharmaceutical composition, or a home care product containing or consisting of at least one active substance and / or additive, or a cosmetic, or a pharmaceutical composition, or a home care product.
[0026] Alternatively, in a first aspect, the invention relates to: (a2) 2,3-heptanediol; (b2) at least one natural polymer; and (c2) optionally, a cosmetic, or a pharmaceutical composition, or a home care product containing or consisting of at least one active substance and / or additive, or a cosmetic or pharmaceutical composition relating thereto.
[0027] In a further alternative, in a first aspect, the present invention is: (a3) A mixture comprising 1,2-heptanediol and 2,3-heptanediol, (b3) At least one natural polymer; and (c3) Optionally, at least one active substance and / or additive for a cosmetic, or a pharmaceutical composition, or a home care product, or a cosmetic or pharmaceutical composition comprising or consisting of them. It relates to a composition.
[0028] In a second aspect, the present invention is: (a) At least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms , or a mixture comprising at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms different from the first linear alkanediol, wherein the carbon chain of the first and second linear alkanediols has 5 to 14 carbon atoms ; (b) At least one natural polymer; and (c) Optionally, at least one active substance and / or additive for a cosmetic, or a pharmaceutical composition, or a home care product, or a cosmetic or pharmaceutical composition comprising or consisting of them, or a home care product. It relates to a composition.
[0029] In a preferred variant of the second aspect, the present invention is: (a’) At least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of 5 to 14 carbon atoms, wherein the number of carbon atoms of the first and second alkanediols is the same or different; a mixture; (b’) At least one natural polymer; and (c’) Optionally, for cosmetics, pharmaceutical compositions, or home care products, at least one active substance and / or additive, or consisting of the same, related to cosmetics, pharmaceuticals compositions, or home care products.
[0030] The term "comprising" means that the specified component is essential, but other components may be added and is further included in the present invention.
[0031] The term "consisting of" used in accordance with the present invention means that the total amount of components (a) to (c) amounts to 100% by weight of the total weight of the cosmetic or pharmaceutical composition, and the subject is a closed end and may only include the expressly listed limitations. means.
[0032] When referring to "comprising", the meaning is always, unless the context otherwise indicates, "comprising" or "consisting of", and is intended to cover both meanings as options. means.
[0033] The term "at least one..." means that the cosmetic or pharmaceutical composition according to the present invention may contain one, or two, three, four, five, six, or even more different mixtures of each of the components following said term. means.
[0034] The term "optionally" means that the subsequently described component may be present in the composition, but need not be present, and the description includes variations in which the compound is included or in which the compound is absent. means.
[0035] Alkanediol is a glycol, i.e., a classification of organic compounds belonging to the alcohol family is any of; in the molecule of the glycol, two hydroxyl (-OH) groups are attached to different carbon atoms of the carbon chain.
[0036] In the cosmetic or pharmaceutical composition according to the first aspect of the present invention, or in a home care product Component (a) is 1,2 - heptanediol (a1) or 2,3 - heptanediol (a2), or both heptanediols, that is, a mixture (a3) containing 2,3 - heptanediol in addition to 1,2 - heptanediol. 1,2 - heptandediol (1,2 - heptandediol) belongs to the class of alkanediols and has the general formula:
Chem.
[0037] It is a linear alkanediol having. It has a carbon chain having 7 carbon atoms, and the two functional OH groups of the alkanediol are in the alpha, beta positions and are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain.
Chem.
[0038] 2,3 - heptanediol belongs to the class of alkanediols and has the general formula:
Chem.
[0039] Linear 1,2 - alkanediol has been used for over 15 years as a multifunctional active substance. Short 1,2 -alkanediols are amphiphilic compounds and are thus soluble in both water and cosmetic oils, such as 1,2 -pentanediol and 1,2 -hexanediol. In contrast, 1,2 -octanediol is a solid and tends to precipitate or recrystallize at ≥0.5% in oily solutions as well as in water. On the other hand, 1,2 -decanediol is a solid and is soluble only in cosmetic oils. Apart from moisturization, some 1,2 -alkanediols are used as viscosity modifiers. As such, like 1,2 -pentanediol and 1,2 -hexanediol, they are soluble in both water and cosmetic oils. In contrast, 1,2 -octanediol is a solid and tends to precipitate or recrystallize at ≥0.5% in oily solutions as well as in water. On the other hand, 1,2 -decanediol is a solid and is soluble only in cosmetic oils. Apart from moisturization, some 1,2 -alkanediols are used as viscosity modifiers.
[0040] Component (a) in the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention is, in a first option, at least one linear alkanediol having a carbon chain of 5 to 14 carbon atoms.
[0041] The linear alkanediol of this second aspect is preferably a 2,3 -alkanediol. In such a case, for compositions containing 2,3 -alkanediol and having a chain length of C8 to C10, and thus particularly C8, C9, and C10, although C11 and C12 are also conceivable, a most suitable balance between the antimicrobial effect and compatibility is achieved for compositions preferably also showing C8 to C12. This is advantageous for the use of these 2,3 -alkanediols in cosmetics and pharmaceutical compositions, or cosmetic or pharmaceutical formulations, or home care products. Furthermore, the higher -order 2,3 -alkanediols show good skin feel parameters, and this advantage is combined with the advantage of strong solubility, with the result that 2,3 -alkanediols become extremely useful for cosmetic formulations on their own, but also as a combination partner with other alkanediols, while improving compatibility, as shown below. It is useful for maintaining or even enhancing additional properties, such as antimicrobial effects, as if present. It will become.
[0042] Furthermore, in the second option of this second aspect, component (a) is a first linear alkane diol combined with a second linear alkane diol, preferably at least one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, and 5 to 14 It may include at least one second linear alkane diol having a carbon chain of carbon atoms. Accordingly, the present invention also encompasses mixtures containing the first and second alkane diols described herein. It may contain. The first linear alkane diol of the present invention can be selected from the same list and types of compounds as the linear alkane diol according to the first option of the second aspect hereinafter, so it is generally referred to as a linear alkane diol, which can also be the first linear alkane diol. In a mixture of the first and second linear alkane diols, when they are specifically different, the specific terms "first" and "second" are used to distinguish the two alkane diol components.
[0043] The phrase "at least one linear alkane diol" or "at least one first linear alkane diol" as used in this document means that the composition can contain one linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or more than one linear alkane diol, or having a carbon chain of 5 to 14 carbon atoms. As such, it can be selected from the same list and types of compounds as the linear alkane diol according to the first option of the second aspect hereinafter, So it is generally referred to as a linear alkane diol, which can also be the first linear alkane diol. In a mixture of the first and second linear alkane diols, when they are specifically different, the specific terms "first" and "second" are used to distinguish the two alkane diol components. It can also be. In the case where they are specifically different, the specific terms "first" and "second" are used to distinguish the two alkane diol components. It is used.
[0044] The phrase "at least one linear alkane diol" or "at least one first linear alkane diol" as used in this document means that the composition can contain one linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or more than one linear alkane diol, or having a carbon chain of 5 to 14 carbon atoms. The carbon chain of carbon atoms, the composition can contain one linear alkane diol, or one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or can contain more than one linear alkane diol, or having a carbon chain of 5 to 14 carbon atoms. The carbon chain of carbon atoms, the composition can contain one linear alkane diol, or one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or can contain more than one linear alkane diol, or having a carbon chain of 5 to 14 carbon atoms. The carbon chain of carbon atoms, the composition can contain one linear alkane diol, or one first linear alkane diol having a carbon chain of 5 to 14 carbon atoms, or can contain more than one linear alkane diol, or having a carbon chain of 5 to 14 carbon atoms. It may have a carbon chain of carbon atoms. or more than one first linear alkanediol, i.e., two, three, four or more different linear alkanediols, or a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms may be included.
[0045] The linear alkanediol or the first linear alkanediol preferably consists of a chain of 5 to 14 carbon atoms with two OH functional groups attached to two different carbon atoms in the chain and connected to each other by a single covalent bond.
[0046] In a cosmetic, pharmaceutical composition or home care product according to a second aspect of the present invention, at least one linear alkanediol, or at least one first linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol and tetradecanediol selected from the group consisting of.
[0047] In a preferred variant, at least one linear alkanediol, or at least one first linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol and tridecanediol.
[0048] In a more preferred variant, at least one linear alkanediol, or at least one first linear alkanediol has an alkanediol having 5 to 13 odd carbon atoms All, namely pentanediol, heptanediol, nonanediol, undecanedi is selected from the group consisting of all, tridecanediol, and mixtures thereof.
[0049] In a further more preferred variant, at least one linear alkanediol, or at least one first linear alkanediol is an alkanediol having 7, 9, 11, and 13 odd carbon atoms namely heptanediol, nonanediol, undecanedi ol and tridecanediol, selected from the group consisting of, or 9 and 11 odd number of carbon atoms alkanediol, namely nonanediol and undecanediol selected from the group consisting of, or 9 and 13 odd number of carbon atoms alka nediol, namely nonanediol and tridecanediol selected from the group consisting of , or 11 and 13 odd number of carbon atoms alkanediol, namely undecanediol and tridecanediol selected from the group consisting of.
[0050] In a further more preferred variant, at least one linear alkanediol, or at least one first linear alkanediol is pentanediol, hexanediol, hept anediol or octanediol.
[0051] In the most preferred variant, at least one linear alkanediol, or at least the first one linear alkanediol is heptanediol.
[0052] In an alternative, the cosmetic, or pharmaceutical composition, or home care product according to the second aspect of the invention has at least one first linear a having a carbon chain of 5 to 14 carbon atoms Lukan diol, and one or more having a carbon chain of 5 to 14 carbon atoms, a mixture containing a second linear alkane diol different from the first linear alkane diol .
[0053] This means that the alkane diol mixture has a carbon chain of 5 to 14 carbon atoms, at least one first linear alkane diol, and one or more, i.e., 2, 3, 4 or more, having a carbon chain of 5 to 14 carbon atoms second linear alkane diols. In this option, the first linear alkane diol can generally be any of the alkane diols described herein for linear alkane diols, and particularly for the first option of the second aspect. For example, the mixture may contain one first linear alkane diol and 1, 2, 3 or more second linear alkane diols; or the mixture may contain two first linear alkane diols and 1, 2, 3 or more
[0054] second linear alkane diols, etc., provided that in each mixture, the first linear alkane diol and the second linear alkane diol are different from each other. The term "different from each other" means that the first linear alkane diol and the second linear alkane diol in the mixture are different with respect to the length of the carbon chain, i.e., the number of carbon atoms, and / or with respect to its structural isomerism, or with respect to its stereoisomerism. Similarly, the first linear alkane diol and the second linear alkane diol in the mixture
[0055] The first linear alkane diol and the second linear alkane diol in the mixture are different with respect to the length of the carbon chain, i.e., the number of carbon atoms, and / or with respect to its structural isomerism, or with respect to its stereoisomerism.
[0056] Similarly, the first linear alkane diol and the second linear alkane diol in the mixture The number of carbon atoms in the loop may be the same. For example, the first linear alkanediol and the second linear alkanediol have a carbon chain of 7 carbon atoms, but the first linear alkanediol and the second linear alkanediol are different with respect to their structural isomers or their stereoisomers.
[0057] The second linear alkanediol preferably consists of 2 OH functional groups attached to 2 different carbon atoms in the chain and a chain of 5 to 14 carbon atoms connected to each other by a single covalent bond.
[0058] In the cosmetics, pharmaceutical composition, or home care product according to the second aspect of the present invention, at least one second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol and tetradecanediol.
[0059] In a preferred variant, at least one second linear alkanediol is selected from the group consisting of pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, undecanediol, dodecanediol and tridecanediol. If both the first and second alkanediols are, for example, heptanediol then the heptanediol of the second linear alkanediol is a different structural isomer or stereoisomer from the first linear al kanediol.
[0060] In a more preferred variant, at least one second linear alkanediol is pentanediol ol, hexanediol, heptanediol, octanediol and nonanediol , most preferably selected from the group consisting of heptanediol, octanediol and nonanediol .
[0061] The term "alkanediol" within the context of the present invention also includes its structural isomers or positional isomers. Structural isomers are compounds having the same molecular formula and different connectivity . Positional isomers, a specific form of structural isomerism, are structural isomers that can be seen as differing only in the position of the functional groups in the parent structure, and in this case the position is the position of the two alcohol functional groups.
[0062] Depending on the number of carbon atoms in the carbon chain of the alkanediol, various positional isomers of the alkanediol: (x,x + 1) structural isomers; (x,x + 2) structural isomers; (x,x + 3) structural isomers; etc., and when the alcohol functional groups are at the ends of the carbon chain, alpha,omega structural isomers are present, where x means the number of carbon atoms in the alkanediol chain to which the OH groups of the alkanediol are chemically bonded. For example, when x is 1, the two OH groups of the alkanediol are chemically bonded to the C1 and C2 carbon atoms in the alkanediol chain; when x is 2, the two OH groups of the alkanediol are chemically bonded to the C 2 and C3 carbon atoms in the alkanediol chain.
[0063] In the (x,x + 1) structural isomer, the two OH functional groups are vicinal, attached to two different adjacent carbon atoms in the chain. In the (x,x + 2) structural isomer, the two OH functional groups When two carbon atoms are separated by one C atom, they are attached to two different carbon atoms in the chain. In the (x,x+3) structural isomer, when two carbon atoms are separated by two C atoms, the two OH functional groups are attached to two different carbon atoms in the chain. In the alpha,omega structural isomer, the two functional groups are attached to the first C atom and the terminal C atom. In the alpha,omega structural isomer, the two functional groups are attached to the first C atom and the terminal C atom. In the alpha,omega structural isomer, the two functional groups are attached to the first C atom and the terminal C atom.
[0064] In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer.
[0065] In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer. In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal (x,x+1) diol selected from the group consisting of 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols and mixtures thereof, preferably the alpha,beta 1,2 structural isomer.
[0066] In a further preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms In a further preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol having a carbon chain of 5 to 14 carbon atoms , preferably, a non - vicinal (x, x + 2) diol selected from the group consisting of 1,3 - diol, 2,4 - diol, 3,5 - diol, further (x, x + 2) diols and mixtures thereof, preferably an alpha, gamma 1,3 structural isomer. , x + 2) diol and is preferably an alpha, gamma 1,3 structural isomer. ) diol and is preferably an alpha, gamma 1,3 structural isomer.
[0067] A preferred variant of the cosmetic or pharmaceutical composition or home care according to the second aspect of the present invention is that the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a non - vicinal (x, x + 2) diol selected from the group consisting of 1,3 - diol, 2,4 - diol, 3,5 - di ol, 4,6 - diol, further (x, x + 2) diols and mixtures thereof, and is preferably an alpha, gan ma 1,3 - structural isomer. ma 1,3 - structural isomer.
[0068] A further preferred variant of the cosmetic, or pharmaceutical composition, or home care product according to the second aspect of the present invention is that the linear alkanediol having a carbon chain of 5 to 14 carbon atoms is preferably a non - vicinal (x, x + 3) diol selected from the group consisting of 1,4 - diol, 2,5 - diol, further (x, x + 3) diols and their mixtures, and is preferably an alpha, delta 1,4 structural isomer. their mixtures, and is preferably an alpha, delta 1,4 structural isomer.
[0069] A preferred variant of the cosmetic, or pharmaceutical composition, or home care product according to the second aspect of the present invention is that the first linear alkanediol, and / or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms is a non - vicinal (x, x + 3) diol selected from the group consisting of 1,4 - diol, 2,5 - diol, further (x, x + 3) diols and mixtures thereof, and is preferably an alpha, It is a (x,x + 3) diol, preferably an alpha, delta 1,4 structural isomer.
[0070] In a preferred variant of the cosmetic or pharmaceutical composition or home care product according to the second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, and / or the second linear alkanediol is preferably an alpha, omega alkanediol, more preferably 1,7 - heptanediol or 1,8 - octanediol.
[0071] The proximity (x,x + 1) diol according to the present invention is most preferred, for example alpha, beta or beta, gamma or gamma, delta.
[0072] In a more preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the present invention, the linear al kanediol, especially the first linear alkanediol, and / or the second linear alkan diol is 1,2 - alkanediol, 2,3 - alkanediol, 3,4 - alkan diol, or a mixture thereof, with 2,3 - alkanediol being more preferred.
[0073] The linear alkanediol, especially the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and / or the second linear al kanediol having a carbon chain of 5 to 14 carbon atoms, the 1,2 - alkanediol can preferably be represented by the following formula: can be: 1,2 - pentanediol [Chem.] 1,2 - hexanediol [Chem.] 1,2-Heptanediol
Chem.
Chem.
Chem.
Chem.
Chem.
Chem.
Chem.
Chem.
[0074] The linear alkanediols of the present invention, in particular a first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, and / or a second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, the 2,3-alkanediol may preferably be represented by the following formula: as follows: 2,3-Pentanediol [Chemistry] 2,3 - Hexanediol [Chemistry] 2,3 - Heptanediol [Chemistry] 2,3 - Octanediol [Chemistry] 2,3 - Nonanediol [Chemistry] 2,3 - Decanediol [Chemistry] 2,3 - Undecanediol [Chemistry] 2,3 - Dodecanediol [Chemistry] 2,3 - Tridecanediol [Chemistry] 2,3 - Tetradecanediol [Chemistry]
[0075] Linear alkanediol, preferably a first linear Linear alkanediol, and / or a second straight chain having a carbon chain of 5 to 14 carbon atoms The 3,4-alkanediol of the linear alkanediol is preferably represented by the following formula and can be: 3,4-hexanediol
Chemical formula
Chemical formula
Chemical formula
Chemical formula
Chemical formula
Chemical formula
Chemical formula
Chemical formula
Chemical formula
[0076] In a preferred variant, the cosmetic or pharmaceutical composition according to the second aspect of the invention has from 5 to 14 at least one first linear alkanediol having a carbon chain of from 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of from 5 to 14 carbon atoms, and includes a mixture in which the number of carbon atoms of the first and second alkanediols is the same or different.
[0077] When both the first and second alkanediols have the same number of carbon atoms, such a combination of alkanediols is herein also referred to as a "homoalkanediol mixture" or a "homo combination". For example, the first linear alkanediol and the second linear alkanediol have a carbon chain of 7 carbon atoms, but the first linear alkanediol and the second linear alkanediol differ with respect to their structural isomerism or their stereoisomerism.
[0078] When the first and second alkanediols have different numbers of carbon atoms, such a combination of alkanediols is herein also referred to as a "heteroalkanediol mixture" or a "hetero combination". For example, the first linear alkanediol has a carbon chain of 7 carbon atoms and the second linear alkanediol has a carbon chain of 8 carbon atoms. However, in addition thereto, the first linear alkanediol and the second linear alkanediol may differ with respect to their structural isomerism or their stereoisomerism.
[0079] In a preferred variant of the cosmetic or pharmaceutical composition according to the second aspect of the invention, the linear alkanediol or the first linear alkanediol is: 1,2 - Pentanediol, 2,3 - Pentanediol, 3,4 - Pentanediol, 1,2 - Hexanediol, 2,3 - Hexanediol, 3,4 - Hexanediol, 1,2 - Heptanediol, 2,3 - Heptanediol, 3,4 - Heptanediol, 1,2 - Octanediol, 2,3 - Octanediol, 3,4 - Octanediol, 1,2 - Nonanediol, 2,3 - Nonanediol, 3,4 - Nonanediol, 1,2 - Decanediol, 2,3 - Decanediol, 3,4 - Decanediol, 1,2 - Undecanediol, 2,3 - Undecanediol, 3,4 - Undecanediol and 1,2 - Dodecanediol, 2,3 - Dodecanediol, 3,4 - Dodecanediol, 1,2 - Tridecanediol, 2,3 - Tridecanediol, 3,4 - Tridecanediol is selected from the group consisting of and mixtures thereof.
[0080] Among the aforementioned linear alkanediols, or among the first linear alkanediols, the following (x , x + 1) structural isomers are preferred: 1,2 - Pentanediol, 2,3 - Pentanediol , 1,2 - Hexanediol, 2,3 - Hexanediol, 1,2 - Heptanediol , 2,3 - Heptanediol, 2,3 - Octanediol, 2,3 - Nonanediol, 2 , 3 - Decanediol, 2,3 - Undecanediol, 2,3 - Dodecanediol, 2, 3 - Tridecanediol or mixtures thereof. The alkanediol is liquid at a purity of 90 to 99 %.
[0081] Among the aforementioned liquid alkanediols, 1,2 - Pentanediol, 2,3 - Pentanedi All, 1,2 - hexanediol, 2,3 - hexanediol, 1,2 - heptanediol 1, 2 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol Or a mixture of said liquid alkanediols is particularly preferred. Said alkanediol can be more easily incorporated into semi - finished or finished products containing natural polymers.
[0082] In a more preferred variant, at least one linear alkanediol, or at least one first linear alkanediol, is a 1,2 - alkanediol having 5 to 13 odd - numbered carbon atoms, i.e., 1,2 - pentanediol, 1,2 - heptanediol, 1, 2 - nonanediol, 1,2 - undecanediol, 1,2 - tridecanediol, and mixtures thereof, selected from the group consisting of
[0083] In a more preferred variant, the linear alkanediol or the first linear alkanediol is a 1,2 - alkanediol having 7, 9, 11, and 13 odd - numbered carbon atoms, i.e., 1,2 - heptanediol, 1,2 - nonanediol, 1,2 - undecanediol or 1,2 - tridecanediol, selected from the group consisting of Or a 1,2 - alkanediol having 9 and 11 odd - numbered carbon atoms, i.e., 1,2 - nonanediol and 1,2 - undecanediol, selected from the group consisting of Or a 1,2 - alkanediol having 9 and 13 odd - numbered carbon atoms, i.e., 1,2 - nonanediol and 1,2 - tridecanediol, selected from the group consisting of It is selected from the group consisting of 1,2-tridecanediol.
[0084] In a more preferred variant, at least one linear alkanediol, or at least one The first linear alkanediol has 5 to 13 odd carbon atoms and is 2,3-alkanediol, i.e., 2,3-pentanediol, 2,3-heptanediol, 2, 3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol, and is selected from the group consisting of mixtures thereof.
[0085] In an even more preferred variant, the linear alkanediol or the first linear alkanediol is 2,3-alkanediol having 7, 9, 11, and 13 odd carbon atoms, i.e., 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol or 2,3-tridecanediol, and is selected from the group consisting of; or 2,3-alkanediol having 9 and 11 odd carbon atoms, i.e., 2,3-nonanediol and 2,3-undecanediol, and is selected from the group consisting of; or 2,3-alkanediol having 9 and 13 odd carbon atoms, i.e., 2,3-nonanediol and 2,3-tridecanediol, and is selected from the group consisting of; or 2,3-alkanediol having 11 and 13 odd carbon atoms, i.e., 2,3-undecanediol and 2,3-tridecanediol, and is selected from the group consisting of.
[0086] In a further preferred variant of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the linear alkanediol or the first linear alkanediol is: 1,2 - Pentanediol, 2,3 - Pentanediol, 3,4 - Pentanediol, 1,2 - Hexanediol, 2,3 - Hexanediol, 3,4 - Hexanediol, 1,2 - Heptanediol, 2,3 - Heptanediol, 3,4 - Heptanediol, 1,2 - Octanediol, 2,3 - Octanediol, 3,4 - Octanediol, 1,2 - Nonanediol, 2,3 - Nonanediol, 3,4 - Nonanediol, and is selected from the group consisting of these mixtures.
[0087] More preferably, in the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the linear alkanediol or the first linear alkanediol is 1,2 - Pentanediol, 2,3 - Pentanediol, 3,4 - Pentanediol and mixtures thereof selected from the group consisting of, or 1,2 - Heptanediol, 2,3 - Hepta nediol, 3,4 - Heptanediol, and mixtures thereof selected from the group consisting of However, the linear alkanediol or the first linear alkanediol is preferably 1,2 - Octanediol, 2,3 - Octanediol, 3,4 - Octanediol, and can also be selected from the group consisting of mixtures thereof.
[0088] Even more preferably, in the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the linear alkanediol or the first linear alkanediol is 1, 2 - Heptanediol, 2,3 - Heptanediol, or the alpha,beta or beta,gamma diol as a mixture thereof However, the linear alkanediol or The first linear alkanediol is preferably 1,2-octanediol, 2,3-octanediol, or an alpha,beta or beta,gamma diol such as a mixture thereof. Mixtures containing 1,2-heptanediol and 2,3-octanediol, or mixtures containing 1,2-octanediol and 2,3-heptanediol are also conceivable. The most preferred linear alkanediol or first linear alkanediol is 1,2-pentanediol, or 2,3-pentanediol, or 1,2-hexanediol, or 2,3-hexanediol, or 1,2-heptanediol, or 2,3-heptanediol, or 1,2-octanediol, or 2,3-octanediol, or 1,2-nonanediol, or 2,3-nonanediol. Similarly, in a further preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the linear alkanediol or first linear alkanediol is: Selected from the group consisting of 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, and mixtures thereof. Even more preferred, the linear alkanediol or first linear alkanediol in the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention is 1,2-
[0089] pentanediol, or 2,3-pentanediol, or 1,2-hexanediol, or 2,3-hexanediol, or 1,2-heptanediol, or 2,3-heptanediol, or 1,2-octanediol, or 2,3-octanediol, or 1,2-nonanediol, or 2,3-nonanediol.
[0090]
[0091] Nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures thereof, or preferably 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, and mixtures thereof, or preferably 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, and mixtures thereof. It is selected from the group consisting of, or may also be preferably selected from the group consisting of 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, and mixtures thereof. Or may also be preferably selected from the group consisting of 1,2-undecanediol, 2,3-undecanediol, 3 ,4-undecanediol, and mixtures thereof.
[0092] Even more preferably, in the cosmetics, pharmaceutical composition, or household care product according to the second aspect of the present invention, the linear alkanediol or the first linear alkanediol is 1, 2-nonanediol, 2,3-nonanediol, or alpha, beta or beta, gamma diol as a mixture thereof. However, the linear alkanediol or the first linear alkanediol may also preferably be 1,2-decanediol, 2,3-decanediol, or a mixture thereof. Furthermore, the linear alkanediol or the first linear alkanediol may also preferably be 1, 2-undecanediol, 2,3-undecanediol, or a mixture thereof. A mixture containing 1,2-nonanediol and / or 2,3-decanediol and / or 2,3-undecanediol, or a mixture containing 1,2-decanediol and / or
[0093] 2,3-nonanediol and / or 2,3-undecanediol, or a mixture containing 1,2-undecanediol and / or 2,3-nonanediol and 2,3-decanediol is also conceivable. 1,2-Nonanediol and / or 2,3-decanediol and / or 2,3-undecanediol, or a mixture containing 1,2-decanediol and / or 2,3-nonanediol and / or 2,3-undecanediol, or a mixture containing 1,2-undecanediol and / or 2,3-nonanediol and 2,3-decanediol is also conceivable. Mixtures containing 1,2-undecanediol and / or 2,3-nonanediol and 2,3-decanediol are also conceivable.
[0094] In a preferred variant of the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention, the second linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, 1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol , 1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol and is selected from the group consisting of mixtures thereof.
[0095] Among the aforementioned second linear alkanediols, the following (x,x+1) structural isomers: 1,2 -pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3- hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-o ctanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undeca nediol, 2,3-dodecanediol, or 2,3-tridecanediol are preferred . The alkanediol is liquid at a purity of 90 to 99%.
[0096] Among the aforementioned liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol or a mixture of the aforementioned liquid alkanediols is particularly preferred. The alkanediol can be more easily incorporated into semi-finished or finished products containing natural polymers.
[0097] In a more preferred variant, the second linear alkanediol is a 1,2-alkanediol having 5 to 13 odd carbon atoms, i.e., 1,2-pentanediol, 1,2-hexanediol, 1,2-nonanediol, 1,2-undecanediol, 1,2-tridecanediol, and mixtures thereof.
[0098] In a more preferred variant, the second linear alkanediol is a 1,2-alkanediol having 7, 9, 11 and 13 odd carbon atoms, i.e., 1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol and 1,2-tridecanediol, selected from the group consisting of, or a 1,2-alkanediol having 9 and 11 odd carbon atoms, i.e., 1,2-nonanediol and 1,2-undecanediol, selected from the group consisting of, or a 1,2-alkanediol having 9 and 13 odd carbon atoms, i.e., 1,2-nonanediol and 1,2-tridecanediol, selected from the group consisting of, or a 1,2-alkanediol having 11 and 13 odd carbon atoms, i.e., 1,2-undecanediol and 1,2-tridecanediol, Selected from the group consisting of all.
[0099] In a more preferred variant, the second linear alkanediol is a 2,3-alkanediol having 5 to 13 odd carbon atoms, i.e., 2,3-pentanediol, 2,3-hexanediol, 2,3-nonanediol, 2,3-undecanediol, 2,3-tridecanediol, and mixtures thereof, selected from the group consisting of. In an even more preferred variant, the second linear alkanediol is a 2,3-alkanediol having 7, 9, 11, and 13
[0100] odd carbon atoms, i.e., 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol, and 2,3-tridecanediol, selected from the group consisting of, or a 2,3-alkanediol having 9 and 11 odd carbon atoms, i.e., 2,3-nonanediol and 2,3-undecanediol, selected from the group consisting of, or a 2,3-alkanediol having 9 and 13 odd carbon atoms, i.e., 2,3-nonanediol and 2,3-tridecanediol, selected from the group consisting of, or a 2,3-alkanediol having 11 and 13 odd carbon atoms, i.e., 2,3-undecanediol and 2,3-tridecanediol, selected from the group consisting of. In a more preferred variant of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the second linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol,
[0101] In a preferred variant of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the second linear alkanediol is: 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,2 - heptanediol, 2,3 - heptanediol, 3,4 - heptanediol, 1,2 - octanediol, 2,3 - octanediol, 3,4 - octanediol, 1,2 - nonanediol, 2,3 - nonanediol, 3,4 - nonanediol, and is selected from the group consisting of these mixtures.
[0102] More preferably, in the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the second linear alkanediol is 1,2 - pentanediol, 2,3 - pentanediol, 3,4 - pentanediol, and is selected from the group consisting of mixtures thereof. However, the second linear alkanediol is preferably 1,2 - hexanediol, 2,3 - hexanediol, 3,4 - hexanediol, and can also be selected from the group consisting of mixtures thereof, or is preferably 1,2 - heptanediol, 2,3 - heptanediol, 3,4 - heptanediol, and can also be selected from the group consisting of mixtures thereof.
[0103] Even more preferably, in the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention, the second linear alkanediol is 1,2 - pentanediol, 2, 3 - pentanediol or alpha, beta or beta, gamma diol as a mixture thereof. However, the second linear alkanediol can preferably also be 1,2 - hexanediol, or 2,3 - hexanediol, or a mixture thereof. Mixtures containing 1,2 - pentanediol and 2,3 - hexanediol, or 2,3 - pentanediol and 1,2 - hexanediol are also conceivable.
[0104] Most preferably, the second linear alkanediol is 1,2-pentanediol or 2 ,3-pentanediol, or 1,2-hexanediol or 2,3-hexanedi ol, or 1,2-heptanediol or 2,3-heptanediol, or 2 ,3-octanediol, or 2,3-nonanediol.
[0105] In a particularly preferred variant, the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols, a cosmetic, or a pharmaceutical composition, or a home care product, comprises any one of the following mixtures / combinations: · A mixture comprising 1,2-pentanediol and 2,3-pentanediol, or · A mixture comprising 1,2-hexanediol and 2,3-hexanediol, or · A mixture comprising 1,2-heptanediol and 2,3-heptanediol, or · A mixture comprising 1,2-octanediol and 2,3-octanediol, or · A mixture comprising 1,2-nonanediol and 2,3-nonanediol, or · A mixture comprising 1,2-decanediol and 2,3-decanediol, or · A mixture comprising 1,2-undecanediol and 2,3-undecanediol, or · A mixture comprising 1,2-dodecanediol and 2,3-dodecanediol, or · A mixture comprising 1,2-tridecanediol in combination with 2,3-tridecanediol .
[0106] In the homoalkanediol mixture, the first linear alkanediol and the second linear The alkanediols have the same number of carbon atoms.
[0107] Particularly advantageous is a mixture containing 1,2-pentanediol in combination with 2,3-pentanediol, or a mixture containing 1,2-heptanediol in combination with 2,3-heptanediol and / or 3,4-heptanediol, or a mixture containing 1,2-octanediol in combination with 2,3-octanediol and / or 3,4-octanediol.
[0108] Due to their excellent antimicrobial effect, a homoalkanediol mixture containing 1,2-octanediol and 2,3-octanediol, or a homoalkanediol mixture containing 1,2-nonanediol and 2,3-nonanediol, or a homoalkanediol mixture containing 1,2-decanediol and 2,3-decanediol is most preferred.
[0109] The above-mentioned homoalkanediol mixture according to the second aspect of the present invention, containing 1,2-alkanediol and 2,3-alkanediol, is characterized by a synergistically enhanced action, i.e., the alkanediol mixture reduces the microbial load caused by Gram(+) bacteria, Gram(-) bacteria, yeast, and molds in cosmetic or pharmaceutical preparations containing natural polymers, or home care products, by synergistic means, as demonstrated in the following examples, compared to each single 1,2-alkanediol or 2,3-alkanediol substance.
[0110] The said synergistic effect or action in reducing the microbial load is for 1,2-pentanediol and It is found in a homogeneous mixture containing 2,3 - pentanediol.
[0111] The synergistic effect in reducing the microbial load is also observed in a homogeneous mixture containing 1,2 - hexanediol and 2,3 - hexanediol.
[0112] A homogeneous mixture containing 1,2 - heptanediol and 2,3 - heptanediol is particularly beneficial because it has a specific and significant synergistic effect on reducing the microbial load in cosmetic or pharmaceutical preparations containing natural polymers, or home care products. load reduction.
[0113] An alkandiol mixture containing 1,2 - octanediol and 2,3 - octanediol, or an alkandiol mixture containing 1,2 - nonanediol and 2,3 - nonanediol is particularly advantageous because the mixture is effective in the synergistic reduction of the microbial load in cosmetic or pharmaceutical preparations containing natural polymers, or home care products. load reduction.
[0114] Also, an alkandiol mixture containing 1,2 - decanediol and 2,3 - decanediol, or an alkandiol mixture containing 1,2 - undecanediol and 2,3 - undecanediol synergistically reduces the microbial load in cosmetics or pharmaceuticals containing natural polymers, or home care products. load reduction.
[0115] The synergistic effect also applies to an alkandiol mixture containing 1,2 - dodecanediol and 2,3 - dodecanediol, or an alkandiol mixture containing 1,2 - tridecanediol and 2,3 - tridecanediol. load reduction.
[0116] The aforementioned homomalkanediol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol can synergistically lower the concentration of colony-forming units (CFU). In the case of the aforementioned homomalkanediol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol, the concentration of colony-forming units (CFU) can be synergistically reduced. It is possible to reduce it.
[0117] The synergistically enhanced effect on the microbial load of natural polymers mentioned above is particularly remarkable in a homomixture containing 1,2-heptanediol and 2,3-heptanediol, or a homomixture containing 1,2-octanediol and 2,3-octanediol, or a homomixture containing 1,2-nonanediol and 2,3-nonanediol, compared to the corresponding individual 1,2-alkanediol or 2,3-alkanediol substances. In a homomixture containing 1,2-heptanediol and 2,3-heptanediol, or a homomixture containing 1,2-octanediol and 2,3-octanediol, or a homomixture containing 1,2-nonanediol and 2,3-nonanediol, compared to the corresponding individual 1,2-alkanediol or 2,3-alkanediol substances, it is particularly remarkable. -octanediol and 2,3-octanediol, or a homomixture containing 1,2 -nonanediol and 2,3-nonanediol, compared to the corresponding individual 1, 2-alkanediol or 2,3-alkanediol substance, it is particularly remarkable. .
[0118] The reduction of the microbial load of natural polymers can significantly improve the storage stability and thus the shelf life of cosmetic or pharmaceutical preparations, or home care products.
[0119] Furthermore, by mixing the corresponding liquid 2,3-alkanediol with solid 1,2-alkanediol, solid 1,2-alkanediol, such as 1,2-octanediol , 1,2-nonanediol can be dissolved to obtain a liquid alkanediol mixture. 2,3 -alkanediol functions as a solvent for solid 1,2-alkanediol. Such a liquid mixture has the advantage that, firstly, the availability of solid 1,2-alkanediol in the mixture is improved, and secondly, the incorporation of solid 1,2-alkanediol into semi-finished or final products is promoted. This effect is that lipophilic 1,2-alkanediol having a carbon chain of 8 or more carbon atoms tends to migrate into the oil phase when used alone In such a liquid mixture, firstly, the availability of solid 1,2-alkanediol in the mixture is improved, and secondly, the incorporation of solid 1,2-alkanediol into semi-finished or final products is promoted. This effect is that lipophilic 1,2-alkanediol having a carbon chain of 8 or more carbon atoms tends to migrate into the oil phase when used alone In such a liquid mixture, firstly, the availability of solid 1,2-alkanediol in the mixture is improved, and secondly, the incorporation of solid 1,2-alkanediol into semi-finished or final products is promoted. This effect is that lipophilic 1,2-alkanediol having a carbon chain of 8 or more carbon atoms tends to migrate into the oil phase when used alone In such a liquid mixture, firstly, the availability of solid 1,2-alkanediol in the mixture is improved, and secondly, the incorporation of solid 1,2-alkanediol into semi-finished or final products is promoted. This effect is that lipophilic 1,2-alkanediol having a carbon chain of 8 or more carbon atoms tends to migrate into the oil phase when used alone In the case where lipophilic 1,2-alkanediol having a carbon chain of 8 or more carbon atoms is used alone, it tends to migrate into the oil phase It is particularly advantageous for lotions. By mixing with the corresponding liquid 2,3 - alkanediol, 1 ,2 - alkanediol remains in the aqueous phase where microbial contamination usually occurs. This is particularly beneficial for the expression of the antimicrobial effect of 1,2 - alkanediol in the aqueous phase.
[0120] The availability of 1,2 - octanediol or 1,2 - nonanediol can also be improved in the final use by a solution of solid 1,2 - octanediol in liquid 2,3 - octanediol or solid 1,2 - nonanediol in liquid 2,3 - nonanediol.
[0121] Furthermore, the above - mentioned alkanediol mixture containing 1,2 - alkanediol and the corresponding 2,3 - alkanediol enables cold preparation of cosmetics or pharmaceutical formulations, or home care products, i.e., heating during preparation is no longer essential. Furthermore, the above - mentioned alkanediol mixture containing 1,2 - alkanediol and the corresponding 2,3 - alkanediol improves the wettability of natural polymers. Without adding such an alkanediol mixture, natural polymer formulations may separate. Furthermore, the above - mentioned alkanediol mixture containing 1,2 - alkanediol and the corresponding 2,3 - alkanediol prevents polymer aggregation of natural polymers.
[0122] Therefore, due to the above - mentioned properties of the described alkanediol mixture containing 1,2 - alkanediol and each 2,3 - alkanediol, the processability in formulations can be improved.
[0123] Therefore, an active antimicrobial agent mixture can maintain the antimicrobial effect while improving the processing in formulations. When combined to improve workability, a good balance can be achieved. The above-mentioned 1 ,2-alkanediol and the combination of the corresponding 2,3-alkanediol are 1,2- alkanediol substance or 2,3-alkanediol substance alone, and solve this balance problem. This is, for example, 1,2-pentanediol and 2,3-pentane diol, and also includes 1,2-hexanediol and 2,3-hexanediol, and is fully achieved by the combination. For example, combinations including 1,2-heptanediol and 2,3-heptanediol, and also 1,2-octanediol and 2,3-octanediol, also show this effect. The same is true for 1,2-nona diol combined with 2,3-nonanediol, and also for 1,2-decanediol combined with 2,3-decanediol.
[0124] The above-mentioned homoalkanediol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol exhibits remarkable synergistic activity and is clearly superior to the corresponding 1,2-alkanediol or 2,3-alkanediol having the same concentration individually.
[0125] In a particularly preferred variant, the cosmetic, pharmaceutical composition or home care product according to the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols thus comprises any one of the following mixtures / combinations: · 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-Nonanediol, 1,2-decanediol, 1,2-undecanediol, 1, 2-dodecanediol, or 1,2-tridecanediol in combination with one of 1, 2-pentanediol; ·1,2-Pentanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1, 2-doedecanediol, or 1,2-tridecanediol in combination with one of 1, 2-hexanediol; ·1,2-Pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1, 2-doedecanediol, or 1,2-tridecanediol in combination with one of 1 ,2-heptanediol; ·1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1, 2-doedecanediol, or 1,2-tridecanediol in combination with one of 1 ,2-octanediol; ·1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, 1,2-undecanediol, 1 ,2-doedecanediol, or 1,2-tridecanediol in combination with one of 1,2-nonanediol; ·1,2-Pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-undecanediol, 1 , 2 - decanediol, or in combination with one of 1,2 - tridecanediol 1,2 - decanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - dodecanediol, or in combination with one of 1,2 - tridecanediol - undecanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, or in combination with one of 1,2 - tridecanediol 2 - dodecanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, or in combination with one of 1,2 - dodecanediol 2 - tridecanediol; · 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, 1, 2 - dodecanediol, or in combination with one of 1,2 - tridecanediol , 3 - pentanediol; · 1,2 - pentanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, 1, 2 - dodecanediol, or in combination with one of 1,2 - tridecanediol , 3 - hexanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, 1, 2 - dodecanediol, or 1,2 - tridecanediol, in combination with one of 2 ,3 - heptanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, 1, 2 - dodecanediol, or 1,2 - tridecanediol, in combination with one of 2 ,3 - octanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - decanediol, 1,2 - undecanediol, 1 ,2 - dodecanediol, or 1,2 - tridecanediol, in combination with one of 2,3 - nonanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - undecanediol, 1 ,2 - dodecanediol, or 1,2 - tridecanediol, in combination with one of 2,3 - decanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - dodecanediol, or 1,2 - tridecanediol, in combination with one of 2,3 - undecanediol; · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, or 2, 3 - dodecanediol in combination with one of 1,2 - tridecanediol; or · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, or 2,3 - tridecanediol in combination with one of 1,2 - dodecanediol; · 2,3 - hexanediol, 2,3 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2, 3 - dodecanediol, or 2, 3 - pentanediol in combination with one of 2,3 - tridecanediol; · 2,3 - pentanediol, 2,3 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2, 3 - dodecanediol, or 2, 3 - hexanediol in combination with one of 2,3 - tridecanediol; · 2,3 - pentanediol, 2,3 - hexanediol, 2,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2, 3 - dodecanediol, or 2, 3 - heptanediol in combination with one of 2,3 - tridecanediol; · 2,3 - pentanediol, 2,3 - hexanediol, 2,3 - heptanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2, 3-Dodecanediol, or 2,3-tridecanediol, in combination with one of 2,3-octanediol; · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-decanediol, 2,3-undecanediol, 2 ,3-dodecanediol, or 2,3-tridecanediol, in combination with one of 2 ,3-nonanediol; · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-undecanediol, 2 ,3-dodecanediol, or 2,3-tridecanediol, in combination with one of 2 ,3-decanediol; · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -dodecanediol, or 2,3-tridecanediol, in combination with one of 2,3 -undecanediol; · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -undecanediol, or 2,3-tridecanediol, in combination with one of 2, 3-dodecanediol; or · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -undecanediol, or 2,3-dodecanediol, in combination with one of 2,3 -tridecanediol.
[0126] In a detailed preferred variant, the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols, thus, the cosmetic, pharmaceutical composition or home care product according to the invention may comprise any of the following mixtures / combinations: · A mixture comprising 1,2 - heptanediol and 1,2 - pentanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - hexanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - octanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - nonanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - decanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - undecanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - dodecanediol, or · A mixture comprising 1,2 - heptanediol and 1,2 - tridecanediol.
[0127] In a detailed preferred variant, the second aspect of the invention comprising a mixture or combination comprising at least one first linear alkanediol and one or more second linear alkanediols, thus, the cosmetic, pharmaceutical composition or home care product according to the invention may comprise any of the following mixtures / combinations: · A mixture comprising 1,2 - heptanediol and 2,3 - pentanediol, or · A mixture comprising 1,2 - heptanediol and 2,3 - hexanediol, or · A mixture comprising 1,2 - heptanediol and 2,3 - octanediol, or · A mixture comprising 1,2 - heptanediol and 2,3 - nonanediol, or · A mixture comprising 1,2 - heptanediol and 2,3 - decanediol, or · A mixture containing 1,2-heptanediol and 2,3-nonanediol, or · A mixture containing 1,2-heptanediol and 2,3-decanediol, or · A mixture containing 1,2-heptanediol and 2,3-undecanediol, or · A mixture containing 1,2-heptanediol and 2,3-dodecanediol, or · A mixture containing 1,2-heptanediol and 2,3-tridecanediol.
[0128] In a detailed preferred variant, the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention, which contains at least one first linear alkanediol and one or a mixture or combination of a plurality of second linear alkanediols, may thus contain any of the following mixtures / combinations: · A mixture containing 1,2-pentanediol and 2,3-pentanediol, · A mixture containing 1,2-pentanediol and 2,3-hexanediol, · A mixture containing 1,2-pentanediol and 2,3-heptanediol, · A mixture containing 1,2-pentanediol and 2,3-octanediol, · A mixture containing 1,2-pentanediol and 2,3-nonanediol, · A mixture containing 1,2-pentanediol and 2,3-decanediol, · A mixture containing 1,2-pentanediol and 2,3-undecanediol, · A mixture containing 1,2-pentanediol and 2,3-dodecanediol, · A mixture containing 1,2-pentanediol and 2,3-tridecanediol, · A mixture containing 1,2-hexanediol and 2,3-pentanediol, · A mixture containing 1,2-hexanediol and 2,3-hexanediol, · A mixture containing 1,2-hexanediol and 2,3-heptanediol, · A mixture containing 1,2-hexanediol and 2,3-octanediol, · A mixture containing 1,2 - hexanediol and 2,3 - heptanediol, · A mixture containing 1,2 - hexanediol and 2,3 - octanediol, · A mixture containing 1,2 - hexanediol and 2,3 - nonanediol, · A mixture containing 1,2 - hexanediol and 2,3 - decanediol, · A mixture containing 1,2 - hexanediol and 2,3 - undecanediol, · A mixture containing 1,2 - hexanediol and 2,3 - dodecanediol, · A mixture containing 1,2 - hexanediol and 2,3 - tridecanediol, · A mixture containing 1,2 - heptanediol and 2,3 - pentanediol, · A mixture containing 1,2 - heptanediol and 2,3 - hexanediol, · A mixture containing 1,2 - heptanediol and 2,3 - heptanediol, · A mixture containing 1,2 - heptanediol and 2,3 - octanediol, · A mixture containing 1,2 - heptanediol and 2,3 - nonanediol, · A mixture containing 1,2 - heptanediol and 2,3 - decanediol, · A mixture containing 1,2 - heptanediol and 2,3 - undecanediol, · A mixture containing 1,2 - heptanediol and 2,3 - dodecanediol, · A mixture containing 1,2 - heptanediol and 2,3 - tridecanediol, · A mixture containing 1,2 - octanediol and 2,3 - pentanediol, · A mixture containing 1,2 - octanediol and 2,3 - hexanediol, · A mixture containing 1,2 - octanediol and 2,3 - heptanediol, · A mixture containing 1,2 - octanediol and 2,3 - octanediol, · A mixture containing 1,2 - octanediol and 2,3 - nonanediol, · A mixture containing 1,2-octanediol and 2,3-decanediol, · A mixture containing 1,2-octanediol and 2,3-undecanediol, · A mixture containing 1,2-octanediol and 2,3-dodecanediol, · A mixture containing 1,2-octanediol and 2,3-tridecanediol, · A mixture containing 1,2-nonanediol and 2,3-pentanediol, · A mixture containing 1,2-nonanediol and 2,3-hexanediol, · A mixture containing 1,2-nonanediol and 2,3-heptanediol, · A mixture containing 1,2-nonanediol and 2,3-octanediol, · A mixture containing 1,2-nonanediol and 2,3-nonanediol, · A mixture containing 1,2-nonanediol and 2,3-decanediol, · A mixture containing 1,2-nonanediol and 2,3-undecanediol, · A mixture containing 1,2-nonanediol and 2,3-dodecanediol, · A mixture containing 1,2-nonanediol and 2,3-tridecanediol, · A mixture containing 1,2-decanediol and 2,3-pentanediol, · A mixture containing 1,2-decanediol and 2,3-hexanediol, · A mixture containing 1,2-decanediol and 2,3-heptanediol, · A mixture containing 1,2-decanediol and 2,3-octanediol, · A mixture containing 1,2-decanediol and 2,3-nonanediol, · A mixture containing 1,2-decanediol and 2,3-decanediol, · A mixture containing 1,2-decanediol and 2,3-undecanediol, · A mixture containing 1,2-decanediol and 2,3-dodecanediol, · A mixture containing 1,2-decanediol and 2,3-tridecanediol, · A mixture containing 1,2-undecanediol and 2,3-pentanediol, · A mixture containing 1,2-undecanediol and 2,3-hexanediol, · A mixture containing 1,2-undecanediol and 2,3-heptanediol, · A mixture containing 1,2-undecanediol and 2,3-octanediol, · A mixture containing 1,2-undecanediol and 2,3-nonanediol, · A mixture containing 1,2-undecanediol and 2,3-decanediol, · A mixture containing 1,2-undecanediol and 2,3-undecanediol, · A mixture containing 1,2-undecanediol and r 2,3-dodecanediol, · A mixture containing 1,2-undecanediol and 2,3-tridecanediol; or · A mixture containing 1,2-dodecanediol and 2,3-pentanediol, · A mixture containing 1,2-dodecanediol and 2,3-hexanediol, · A mixture containing 1,2-dodecanediol and 2,3-heptanediol, · A mixture containing 1,2-dodecanediol and 2,3-octanediol, · A mixture containing 1,2-dodecanediol and 2,3-nonanediol, · A mixture containing 1,2-dodecanediol and 2,3-decanediol, · A mixture containing 1,2-dodecanediol and 2,3-undecanediol, · A mixture containing 1,2-dodecanediol and 2,3-dodecanediol, or · A mixture containing 1,2-dodecanediol and 2,3-tridecanediol.
[0129] In a detailed preferred variation, at least one first linear alkanediol, and one The second aspect of the present invention comprising a mixture or combination comprising one or more second linear alkanediols Cosmetics, pharmaceutical compositions, or home care products according to the aspect, therefore, may contain any of the following mixtures / combinations: · A mixture containing 2,3 - pentanediol and 2,3 - hexanediol, · A mixture containing 2,3 - pentanediol and 2,3 - heptanediol, · A mixture containing 2,3 - pentanediol and 2,3 - octanediol, · A mixture containing 2,3 - pentanediol and 2,3 - nonanediol, · A mixture containing 2,3 - pentanediol and 2,3 - decanediol, · A mixture containing 2,3 - pentanediol and 2,3 - undecanediol, · A mixture containing 2,3 - pentanediol and 2,3 - dodecanediol, · A mixture containing 2,3 - pentanediol and 2,3 - tridecanediol, · A mixture containing 2,3 - hexanediol and 2,3 - pentanediol, · A mixture containing 2,3 - hexanediol and 2,3 - heptanediol, · A mixture containing 2,3 - hexanediol and 2,3 - octanediol, · A mixture containing 2,3 - hexanediol and 2,3 - nonanediol, · A mixture containing 2,3 - hexanediol and 2,3 - decanediol, · A mixture containing 2,3 - hexanediol and 2,3 - undecanediol, · A mixture containing 2,3 - hexanediol and 2,3 - dodecanediol, · A mixture containing 2,3 - hexanediol and 2,3 - tridecanediol, · A mixture containing 2,3 - heptanediol and 2,3 - pentanediol, · A mixture containing 2,3 - heptanediol and 2,3 - hexanediol, · A mixture containing 2,3 - heptanediol and 2,3 - octanediol, · A mixture containing 2,3 - heptanediol and 2,3 - octanediol, · A mixture containing 2,3 - heptanediol and 2,3 - nonanediol, · A mixture containing 2,3 - heptanediol and 2,3 - decanediol, · A mixture containing 2,3 - heptanediol and 2,3 - undecanediol, · A mixture containing 2,3 - heptanediol and 2,3 - dodecanediol, · A mixture containing 2,3 - heptanediol and 2,3 - tridecanediol, · A mixture containing 2,3 - octanediol and 2,3 - pentanediol, · A mixture containing 2,3 - octanediol and 2,3 - hexanediol, · A mixture containing 2,3 - octanediol and 2,3 - heptanediol, · A mixture containing 2,3 - octanediol and 2,3 - nonanediol, · A mixture containing 2,3 - octanediol and 2,3 - decanediol, · A mixture containing 2,3 - octanediol and 2,3 - undecanediol, · A mixture containing 2,3 - octanediol and 2,3 - dodecanediol, · A mixture containing 2,3 - octanediol and 2,3 - tridecanediol, · A mixture containing 2,3 - nonanediol and 2,3 - pentanediol, · A mixture containing 2,3 - nonanediol and 2,3 - hexanediol, · A mixture containing 2,3 - nonanediol and 2,3 - heptanediol, · A mixture containing 2,3 - nonanediol and 2,3 - octanediol, · A mixture containing 2,3 - nonanediol and 2,3 - decanediol, · A mixture containing 2,3 - nonanediol and 2,3 - undecanediol, · A mixture containing 2,3 - nonanediol and 2,3 - dodecanediol, · A mixture containing 2,3-nonanediol and 2,3-tridecanediol, · A mixture containing 2,3-decanediol and 2,3-pentanediol, · A mixture containing 2,3-decanediol and 2,3-hexanediol, · A mixture containing 2,3-decanediol and 2,3-heptanediol, · A mixture containing 2,3-decanediol and 2,3-octanediol, · A mixture containing 2,3-decanediol and 2,3-nonanediol, · A mixture containing 2,3-decanediol and 2,3-undecanediol, · A mixture containing 2,3-decanediol and 2,3-dodecanediol, · A mixture containing 2,3-decanediol and 2,3-tridecanediol, · A mixture containing 2,3-undecanediol and 2,3-pentanediol, · A mixture containing 2,3-undecanediol and 2,3-hexanediol, · A mixture containing 2,3-undecanediol and 2,3-heptanediol, · A mixture containing 2,3-undecanediol and 2,3-octanediol, · A mixture containing 2,3-undecanediol and 2,3-nonanediol, · A mixture containing 2,3-undecanediol and 2,3-decanediol, · A mixture containing 2,3-undecanediol and 2,3-dodecanediol, · A mixture containing 2,3-undecanediol and 2,3-tridecanediol, · A mixture containing 2,3-dodecanediol and 2,3-pentanediol, · A mixture containing 2,3-dodecanediol and 2,3-hexanediol, · A mixture containing 2,3-dodecanediol and 2,3-heptanediol, · A mixture containing 2,3-dodecanediol and 2,3-octanediol, · A mixture containing 2,3-dodecanediol and 2,3-nonanediol, · A mixture containing 2,3-dodecanediol and 2,3-decanediol, · A mixture containing 2,3-dodecanediol and 2,3-dodecanediol, · A mixture containing 2,3-dodecanediol and 2,3-tridecanediol.
[0130] Particularly advantageous is a mixture containing 2,3-hexanediol and 2,3-heptanediol, or a mixture containing 2,3-hexanediol and 2,3-octanediol or a mixture containing 2,3-heptanediol and 2,3-octanediol.
[0131] In the previously described heteroalkanediol mixtures, the first linear alkanediol and the second linear alkanediol have different numbers of carbon atoms.
[0132] The above-described alkanediol mixture according to the second aspect of the invention, containing the first linear alkanediol and the second linear alkanediol, is characterized by a synergistically enhanced action, i.e., the alkanediol mixture reduces the microbial load caused by Gram(+) bacteria, Gram(-) bacteria, yeast, and mold in cosmetic or pharmaceutical preparations containing natural polymers, or in home care products, by a synergistic means as compared to the corresponding individual 1,2-alkanediol or 2,3-alkanediol substances.
[0133] Among the above-described alkanediol mixtures or combinations, particularly advantageous is 1,2-hex Hetero mixtures containing 2,3-octanediol and 1,2-octanediol Hetero mixtures containing hexanediol and 2,3-hexanediol, or 1,2-octanediol It is a heterogeneous mixture containing hexanediol and 2,3-heptanediol.
[0134] These mentioned heteroalkanediol mixtures according to the second aspect of the invention are These mixtures show a synergistically enhanced effect, i.e., they are also effective in cosmetics containing natural polymers. or pharmaceutical preparations, or home care products, to their corresponding single 1,2-alkanediol or 2,3-alkanediol substances, i.e. 1,2-hexyl Sandiol, or 1,2-octanediol, or 2,3-octanediol, or 2,3-Hexanediol or 2,3-Heptanediol showed synergistic effects. Decrease in stages.
[0135] Alkanediol blend containing 1,2-hexanediol and 2,3-octanediol The compound is useful in cosmetic or pharmaceutical preparations containing natural polymers or in home care products. These compounds synergistically reduce the microbial load associated with
[0136] Also, alkanediols including 1,2-octanediol and 2,3-hexanediol The mixture is suitable for use in cosmetics or pharmaceuticals containing natural polymers or in home care products. These compounds synergistically reduce the microbial load associated with
[0137] Synergistic reduction of inherent microbial load in natural polymers was observed with 1,2-octanediol and 2,3-heptanediol in mixtures of alkanediols.
[0138] In the mixture described above, it is possible to reduce the concentration of colony forming units (CFU). It is possible.
[0139] By reducing the pathogen load of the natural polymer, the shelf life of cosmetic or pharmaceutical preparations, or home care products can be significantly extended. The shelf life can be significantly extended.
[0140] Furthermore, by mixing 2,3 - hexanediol or 2,3 - heptanediol with solid 1,2 - octanediol, the solid 1,2 - octanediol can be dissolved to obtain a liquid alkane diol mixture. 2,3 - hexanediol or 2,3 - heptanediol functions as a solvent for solid 1,2 - octanediol. Such a liquid mixture has the advantages that, firstly, the availability of 1,2 - octanediol in the mixture is improved, and secondly, the incorporation of 1,2 - octanediol in semi - finished or final products is promoted. This effect is particularly advantageous for emulsions in which fat - soluble 1,2 - alkanediols having a carbon chain of 8 or more carbon atoms tend to migrate into the oil phase when used alone. By mixing with the corresponding liquid 2,3 - hexanediol or 2,3 - heptanediol, 1,2 - octanediol remains in the aqueous phase where microbial contamination usually occurs. This is particularly beneficial for the expression of the antimicrobial effect of 1,2 - octanediol in the aqueous phase. The solid 1,2 - octanediol can be dissolved to obtain a liquid alkane diol mixture. Furthermore, by mixing 2,3 - hexanediol or 2,3 - heptanediol with solid 1,2 - octanediol, the solid 1,2 - octanediol can be dissolved to obtain a liquid alkane diol mixture. 2,3 - hexanediol or 2,3 - heptanediol functions as a solvent for solid 1,2 - octanediol. Such a liquid mixture has the advantages that, firstly, the availability of 1,2 - octanediol in the mixture is improved, and secondly, the incorporation of 1,2 - octanediol in semi - finished or final products is promoted. This effect is particularly advantageous for emulsions in which fat - soluble 1,2 - alkanediols having a carbon chain of 8 or more carbon atoms tend to migrate into the oil phase when used alone. By mixing with the corresponding liquid 2,3 - hexanediol or 2,3 - heptanediol, 1,2 - octanediol remains in the aqueous phase where microbial contamination usually occurs. This is particularly beneficial for the expression of the antimicrobial effect of 1,2 - octanediol in the aqueous phase. This effect is particularly advantageous for emulsions in which fat - soluble 1,2 - alkanediols having a carbon chain of 8 or more carbon atoms tend to migrate into the oil phase when used alone. By mixing with the corresponding liquid 2,3 - hexanediol or 2,3 - heptanediol, 1,2 - octanediol remains in the aqueous phase where microbial contamination usually occurs. This is particularly beneficial for the expression of the antimicrobial effect of 1,2 - octanediol in the aqueous phase. This is particularly beneficial for the expression of the antimicrobial effect of 1,2 - octanediol in the aqueous phase.
[0141] Furthermore, according to a second aspect of the present invention, the alkane diol mixture described below, namely a hetero - alkane diol mixture containing 1,2 - pentanediol and 2,3 - hexanediol; or a hetero - alkane diol mixture containing 1,2 - pentanediol and 1,2 - heptanediol That is, a hetero - alkane diol mixture containing 1,2 - pentanediol and 2,3 - hexanediol; or a hetero - alkane diol mixture containing 1,2 - pentanediol and 1,2 - heptanediol That is, a hetero - alkane diol mixture containing 1,2 - pentanediol and 2,3 - hexanediol; or a hetero - alkane diol mixture containing 1,2 - pentanediol and 1,2 - heptanediol Heteroalkanediol mixture; or a heteroalkanediol mixture containing 1,2-pentanediol and 2,3-hepta ne-diol; or a heteroalkanediol mixture containing 1,2-pentanediol and 2,3-octanediol; or a heteroalkanediol mixture containing 1,2-pentanediol and 1,2-nonanediol; or a heteroalkanediol mixture containing 1,2-pentanediol and 2,3-nonanediol in which a unique decrease in the pathogen count of natural polymers can be observed compared to the corresponding single 1,2-alkanediol or 2,3-alkanediol compound. The heteroalkanediol mixtures described above exhibit a synergistic activity of reducing the microbial load of cosmetics or pharmaceutical preparations containing natural polymers, or home care products. The enhanced
[0142] action is clearly superior to the corresponding individual 1,2-alkanediol or 2,3-alkanediol against Gram(+) and Gram(-) bacteria, such as E. coli or Salmonella, yeasts and molds, and also. The alkanediol mixture containing 1,2-pentanediol and 2,3-hexanediol synergistically reduces the microbial load in cosmetics or pharmaceutical preparations containing natural polymers, or home care products. Also, the alkanediol mixture containing 1,2-pentanediol and 1,2-heptanediol synergistically reduces the microbial load in cosmetics or pharmaceuticals containing natural polymers, or home care products.
[0143] The alkanediol mixture containing 1,2-pentanediol and 2,3-hexanediol synergistically reduces the microbial load in cosmetics or pharmaceutical preparations containing natural polymers, or home care products.
[0144] Also, the alkanediol mixture containing 1,2-pentanediol and 1,2-heptanediol synergistically reduces the microbial load in cosmetics or pharmaceuticals containing natural polymers, or home care products.
[0145] Synergy in reducing the number of pathogenic bacteria in a mixture containing a natural polymer as a nutrient according to the present invention A synergistic effect can also be observed with an alkane diol mixture containing 1,2 - pentanediol and 2,3 - heptanediol.
[0146] A synergistic reduction in the microbial load in a natural polymer dispersion can also be observed with an alkane diol mixture containing 1,2 - pentanediol and 2,3 - octanediol.
[0147] A synergistic effect in reducing the number of pathogenic bacteria in a mixture containing a natural polymer as a nutrient can also be observed with an alkane diol mixture containing 1,2 - pentanediol and 1,2 - nonanediol.
[0148] Also, an alkane diol mixture containing 1,2 - pentanediol and 2,3 - nonanediol is effective in synergistically reducing the bacterial load in a polymer dispersion containing a natural polymer according to the present invention.
[0149] With all of the mixtures described above, it is possible to reduce the concentration of colony - forming units and the CFU value (CFU = number of colony - forming units).
[0150] Due to the reduction of the pathogenic bacteria load of the natural polymer, the shelf - life of a cosmetic or pharmaceutical preparation, or a home care product can be significantly extended.
[0151] Furthermore, a significant effect of reducing the bioburden is also shown by a heteroalkane diol mixture according to the second aspect of the present invention, namely a heteroalkane diol mixture containing 1,2 - heptanediol and 1,2 - octanediol, or a heteroalkane diol mixture containing 1,2 - heptanediol and 2,3 - A heteroalkanediol mixture containing octanediol, or 1,2-heptanediol and a heteroalkanediol mixture containing 1,2-nonanediol, or 1,2- A mixture of alkanediols containing heptanediol and 2,3-nonanediol or a combination may be observed compared to the corresponding single 1,2-alkanediol or 2,3-alkanediol compound.
[0152] In particular, an alkanediol mixture containing 1,2-heptanediol and 1,2-octanediol significantly reduces the microbial load in a nutrient solution containing natural polymers.
[0153] An alkanediol mixture containing 1,2-heptanediol and 2,3-octanediol shows a synergistically enhanced microbial effect against bacteria such as E.coli or Salmonella, yeast and mold in a polymer dispersion containing the natural polymer according to the present invention.
[0154] Also, an alkanediol mixture containing 1,2-heptanediol and 2,3-nonanediol is effective in synergistically reducing the bacterial load in a polymer dispersion containing the natural polymer according to the present invention as a medium.
[0155] These mixtures can significantly reduce the concentration of colony-forming units (CFU).
[0156] As a result, the reduction of the pathogen load of the natural polymer can significantly extend the shelf life of cosmetics or pharmaceutical preparations, or home care products.
[0157] In particular, an alkandiol mixture containing 1,2-heptanediol and 1,2-nonanediol shows a distinct decrease in the pathogen count in a solution containing a natural polymer, i.e., a synergistic enhancement of activity.
[0158] As a result, due to the reduction of the microbial load of the natural polymer, the storage stability and shelf life of a cosmetic or pharmaceutical preparation, or a home care product can be considerably improved.
[0159] In a preferred variant according to the second aspect of the invention in a cosmetic or pharmaceutical composition or a home care product, the linear alkandiol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol, and mixtures thereof.
[0160] In a more preferred variant of a cosmetic or pharmaceutical composition or a home care product according to the second aspect of the invention, the linear alkandiol is selected from the group consisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures thereof.
[0161] Surprisingly, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, as well as other 2,3-alkandiols such as 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2, 3-dodecanediol and 2,3-tridecanediol, in cosmetics containing natural polymers Or, by addition to pharmaceutical preparations or home care products, the corresponding 1,2-alkanediols, such as 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, showed a marked reduction in microbial load compared thereto.
[0162] Due to the reduction in the microbial load of the natural polymer, the shelf life of cosmetics or pharmaceutical preparations or home care products can be considerably improved using the aforementioned 2,3-alkanediols.
[0163] Furthermore, the aforementioned 2,3-alkanediols are liquids, which can thereby facilitate their incorporation into semi-finished or final products, with the benefit of increased availability in said products. Furthermore, in an emulsion, the 2,3-alkanediols remain in the aqueous phase and, in the event of contamination by microorganisms, can directly exhibit antimicrobial activity and do not tend to migrate into the oil phase.
[0164] Thus, a good balance can be achieved when an active antimicrobial agent mixture is combined to improve the processability in the formulation while maintaining the antimicrobial effect. The aforementioned 2,3-alkanediols solve this balance problem better than the solid 1,2-alkanediol substances.
[0165] In a particularly advantageous variant according to the second aspect of the invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol is a liquid alkanediol.
[0166] The term "liquid alkanediol" within the context of the present invention refers to an alkanediol that is liquid at room temperature or ambient temperature and, under normal pressure, i.e., under standard RTP conditions. It means a constituent component.
[0167] In a highly preferred variant according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol is , 1,2 - pentanediol, 2,3 - pentanediol, 1,2 - hexanediol, 2,3 - hexanediol, 1,2 - heptanediol, 2,3 - heptanediol, 2 ,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, and a liquid alkanediol selected from the group consisting of mixtures thereof. It is.
[0168] Among the aforementioned liquid alkanediols, 1,2 - pentanediol, 2,3 - pentanedi ol, 1,2 - hexanediol, 2,3 - hexanediol, 1,2 - heptanediol ol, 2,3 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol or mixtures thereof are most preferred.
[0169] In a further particularly advantageous variant according to a second aspect of the present invention, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol is characterized by a maximum water solubility of 10 wt% or less. In a preferred variant, the linear alkanediol, or the first linear alkanediol, or the second linear alkanediol has a maximum water solubility of 1 0 wt% or less and 1.2 wt% or more. A more preferred linear alkanediol, or The maximum water solubility of the first linear alkanediol or the second linear alkanediol is 5 wt% or less and 1.4 wt% or more.
[0170] Preferably, the alkanediol having the above water solubility is 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol, and mixtures thereof selected from the group consisting of.
[0171] The water solubility of a substance is the saturated mass concentration of the substance in water at a given temperature. In water The determination of solubility concerns a substantially pure substance that is stable in water and not a volatile substance. The determination of the water solubility of alkanediol is further described in Example 2 below .
[0172] In the context of the present invention, the term "alkanediol" includes its stereoisomers. Stereoisomers are molecules that have the same molecular formula and differ only in the way the atoms are arranged in three-dimensional space . According to the above definition, the linear alkanediol of the present invention, or the first linear alkanediol having a carbon chain of 5 to 14 carbon atoms, or the second linear alkanediol having a carbon chain of 5 to 14 carbon atoms, specifically includes the following stereoisomers as described above : including:
[0173] 1,2-alkanediol stereoisomers: (2S)-pentane-1,2-diol, (2S)-hexane-1,2-diol, (2S)-heptane-1,2-diol, (2S)-octane-1,2-diol, (2S)-nonane-1,2-diol, (2S)-decane-1,2-diol, (2S)-Undecane-1,2-diol (2S)-Dodecane-1,2-diol, (2S)-Tridecane-1,2-diol, (2S)-Tetradecane-1,2-diol, (2R)-Pentane-1,2-diol, (2R)-Hexane-1,2-diol, (2R)-Heptane-1,2-diol, (2R)-Octane-1,2-diol, (2R)-Nonane-1,2-diol, (2R)-Decane-1,2-diol, (2R)-Undecane-1,2-diol, (2R)-Dodecane-1,2-diol, (2R)-Tridecane-1,2-diol, (2R)-Tetradecane-1,2-diol,
[0174] 2,3-Alkane diol stereoisomers: (2S,3S)-Pentane-2,3-diol, (2S,3S)-Hexane-2,3-diol, (2S,3S)-Heptane-2,3-diol, (2S,3S)-Octane-2,3-diol, (2S,3S)-Nonane-2,3-diol, (2S,3S)-Decane-2,3-diol, (2S,3S)-Undecane-2,3-diol (2S,3S)-Dodecane-2,3-diol, (2S,3S)-Tridecane-2,3-diol, (2S,3S)-Tetradecane-2,3-diol, (2R,3R)-Pentane-2,3-diol, (2R,3R)-Hexane-2,3-diol, (2R,3R)-Heptane-2,3-diol, (2R,3R)-Octane-2,3-diol, (2R,3R)-Nonane-2,3-diol, (2R,3R)-Decane-2,3-diol, (2R,3R)-Undecane-2,3-diol, (2R,3R)-Dodecane-2,3-diol, (2R,3R)-Tridecane-2,3-diol, (2R,3R)-Tetradecane-2,3-diol, (2S,3R)-Pentane-2,3-diol, (2S,3R)-Hexane-2,3-diol, (2S,3R)-Heptane-2,3-diol, (2S,3R)-Octane-2,3-diol, (2S,3R)-Nonane-2,3-diol, (2S,3R)-Decane-2,3-diol, (2S,3R)-Undecane-2,3-diol, (2S,3R)-Dodecane-2,3-diol, (2S,3R)-Tridecane-2,3-diol, (2S,3R)-Tetradecane-2,3-diol, (2R,3S)-Pentane-2,3-diol, (2R,3S)-Hexane-2,3-diol, (2R,3S)-Heptane-2,3-diol, (2R,3S)-Octane-2,3-diol, (2R,3S)-Nonane-2,3-diol, (2R,3S)-Decane-2,3-diol, (2R,3S)-Undecane-2,3-diol, (2R,3S)-Dodecane-2,3-diol, (2R,3S)-Tridecane-2,3-diol, and (2R,3S)-Tetradecane-2,3-diol.
[0175] 3,4-Alkane diol stereoisomers: (3R,4R)-Hexane-3,4-diol, (3R,4R)-Heptane-3,4-diol, (3R,4R)-Octane-3,4-diol, (3R,4R)-Nonane-3,4-diol, (3R,4R)-Decane-3,4-diol, (3R,4R)-Undecane-3,4-diol, (3R,4R)-Dodecane-3,4-diol, (3R,4R)-Tridecane-3,4-diol, (3R,4R)-Tetradecane-3,4-diol, (3S,4S)-Hexane-3,4-diol, (3S,4S)-Heptane-3,4-diol, (3S,4S)-Octane-3,4-diol, (3S,4S)-Nonane-3,4-diol, (3S,4S)-Decane-3,4-diol, (3S,4S)-Undecane-3,4-diol, (3S,4S)-Dodecane-3,4-diol, (3S,4S)-Tridecane-3,4-diol, (3S,4S)-Tetradecane-3,4-diol, (3R,4S)-Hexane-3,4-diol, (3R,4S)-Heptane-3,4-diol, (3R,4S)-Octane-3,4-diol, (3R,4S)-Nonane-3,4-diol, (3R,4S)-Decane-3,4-diol, (3R,4S)-Undecane-3,4-diol, (3R,4S)-Dodecane-3,4-diol, (3R,4S)-Tridecane-3,4-diol, (3R,4S)-Tetradecane-3,4-diol, (3S,4R)-Hexane-3,4-diol, (3S,4R)-Heptane-3,4-diol, (3S,4R)-Octane-3,4-diol, (3S,4R)-Nonane-3,4-diol, (3S,4R)-Decane-3,4-diol, (3S,4R)-Undecane-3,4-diol, (3S,4R)-Dodecane-3,4-diol, (3S,4R)-Tridecane-3,4-diol, and (3S,4R)-Tetradecane-3,4-diol.
[0176] In connection with the present text, the term "1,2-diol", "2,3-diol" or "3,4-diol" includes both the corresponding S-configured enantiomers, as well as the R-enantiomers, and any mixtures (mixuters) of these S- and R-configured enantiomers, i.e., mixtures of the racemic compounds of each diol.
[0177] The alkane diol mixture of a cosmetic, or a pharmaceutical composition, or a home care product according to a first aspect of the present invention comprises 1,2-heptanediol and 2,3-heptanediol in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 80:20 to 98:2, or even more preferably in a ratio in the range of 90:10 to 95:5.
[0178] In a cosmetic or pharmaceutical composition according to a first aspect of the present invention, 1,2-heptanediol and 2,3-heptanediol are preferably comprised in the mixture in a ratio in the range of 98:2 to 99.9:0.1.
[0179] In a home care product according to a first aspect of the present invention, 1,2-heptanediol and 2, 3-Heptanediol is contained in the alkanediol mixture preferably in a ratio in the range of 95:5 to 99.9 :0.1.
[0180] Preferably, 1,2-heptanediol and 2,3-heptanediol are contained in the mixture of the cosmetics, or pharmaceutical composition, or home care product according to the first aspect of the present invention in a ratio of ≧95: ≦5, more preferably in a ratio of ≧96:≦4, even more preferably in a ratio of ≧97:≦3 and most preferably in a ratio of ≧98:≦2.
[0181] The mixture of the cosmetics, or pharmaceutical composition, or home care product according to the first aspect of the present invention mostly contains 1,2-heptanediol and 2,3-heptanediol in a ratio of ≧9 5:≦5, including ratios of ≧95.5:≦4.5;≧96:≦4;≧96.5:≦3.5;≧ 97:≦3;≧97.5:2.5 and ≧98.0:≦2.0.
[0182] Even more preferably, the alkanediol mixture of the cosmetics, or pharmaceutical composition, or home care product according to the first aspect of the present invention contains 1,2-heptanediol and 2,3-heptanediol in a ratio of ≧98:≦2, including ratios of ≧98.1:≦1.9;≧98.2:≦1.8; ≧98.3:≦1.7;≧98.4:≦1.6;≧98.5:≦1.5;≧98.6:≦ 1.4;≧98.7:≦1.3;≧98.8:≦1.2;≧98.9:≦1.1;≧99 :≦1.0;≧99.1:≦0.9;≧99.2:≦0.8;≧99.3:≦0.7;≧ 99.4:≦0.6;≧99.5:≦0.5;≧99.6:≦0.4;≧99.7:≦0 .3;≧99.8:≦0.2 and ≧99.9:≦0.1.
[0183] The first linear alkanediol and the second linear alkanediol, as defined in detail above, are present in the alkanediol mixture according to the second aspect of the invention in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, more preferably in a ratio ranging from 80:20 to 98:2, and even more preferably in a ratio ranging from 90:10 to 95:5. In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably included in the mixture in a ratio ranging from 98:2 to 99.9:0.1. In the home care product according to the second aspect of the invention, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture in a ratio preferably ranging from 95:5 to 99.9:0.1. Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2. Most of all the mixtures of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention contain the first linear alkanediol and the second linear alkanediol in a ratio of ≥95:≤5, including ratios of ≥95.5:≤4.5; ≥96:≤4; ≥96.5:≤3.5; ≥97:≤3; ≥97.5:2.5 and ≥98.0:≤2.0.
[0184] In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably included in the mixture in a ratio ranging from 98:2 to 99.9:0.1. In the home care product according to the second aspect of the invention, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture in a ratio preferably ranging from 95:5 to 99.9:0.1. Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2.
[0185] In the home care product according to the second aspect of the invention, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture in a ratio preferably ranging from 95:5 to 99.9:0.1. In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably included in the mixture in a ratio ranging from 98:2 to 99.9:0.1. Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2.
[0186] Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2. In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably included in the mixture in a ratio ranging from 98:2 to 99.9:0.1. In the home care product according to the second aspect of the invention, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture in a ratio preferably ranging from 95:5 to 99.9:0.1. Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2.
[0187] In the cosmetic or pharmaceutical preparation according to the second aspect of the invention, the first linear alkanediol and the second linear alkanediol are preferably included in the mixture in a ratio ranging from 98:2 to 99.9:0.1. Most of all the mixtures of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention contain the first linear alkanediol and the second linear alkanediol in a ratio of ≥95:≤5, including ratios of ≥95.5:≤4.5; ≥96:≤4; ≥96.5:≤3.5; ≥97:≤3; ≥97.5:2.5 and ≥98.0:≤2.0. In the home care product according to the second aspect of the invention, the first linear alkanediol and the second alkanediol are included in the alkanediol mixture in a ratio preferably ranging from 95:5 to 99.9:0.1. Preferably, the first linear alkanediol and the second alkanediol are included in the mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the invention in a ratio of ≥95:≤5, more preferably in a ratio of ≥96:≤4; even more preferably in a ratio of ≥97:≤3, and most preferably in a ratio of ≥98:≤2.
[0188] Even more preferred, the alkanediol mixture of the cosmetic, pharmaceutical composition, or home care product according to the second aspect of the present invention comprises a first linear alkanediol and a second alkanediol in a ratio of ≧98:≦2, ≧98.1:≦1.9, ≧98.2:≦1.8, ≧98.3:≦1.7, ≧98.4:≦1.6, ≧98.5:≦1.5, ≧98.6:≦ 1.4, ≧98.7:≦1.3, ≧98.8:≦1.2, ≧98.9:≦1.1, ≧99 :≦1.0, ≧99.1:≦0.9, ≧99.2:≦0.8, ≧99.3:≦0.7, ≧ 99.4:≦0.6, ≧99.5:≦0.5, ≧99.6:≦0.4, ≧99.7:≦0 .3, ≧99.8:≦0.2, and ≧99.9:≦0.1. Alternatively, the ratio range of the first and second alkanediols is switched such that the second alkanediol is the main component and the first alkanediol is the minor component.
[0189] In an advantageous variant according to the second aspect of the present invention, the mixture comprises, as the first linear alkanediol, a 1,2-alkanediol, such as 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol, and, as the second linear alkanediol, the corresponding 2,3-alkanediol, such as 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol,
[0190] -ol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol, in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, and more preferably in a range of ratio of 80:20 to 98:2, and even more preferably in a range of ratio of
[0191] For the said mixture as well, the ratio of the first linear alkanediol:the second alkanediol, or the range of the said ratio applies.
[0192] In a further modification, according to the second aspect of the present invention, the mixture comprises, as the first linear alkanediol, a 2,3-alkanediol, such as 2,3-pentanediol, 2,3- hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3- nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dode canediol, or 2,3-tridecanediol, and, as the second linear alkanediol, the corresponding 1,2-alkanediol, such as 1,2-pentanediol, 1,2- hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2- nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dode canediol, or 1,2-tridecanediol, in a ratio in the range of 50:50 to 99.9:0.1 preferably in a ratio in the range of 75:25 to 99:1, and more preferably in a range of ratio of 80:20 to 98:2, and even more preferably in a range of ratio of 90:10 to 95:5.
[0193] Similarly, in the said mixture, the ratio of the first linear alkanediol to the second alkanediol, or the range of the said ratio, applies.
[0194] In a more advantageous variant according to the second aspect of the invention, a mixture comprising 1,2-alkanediol as the first linear alkanediol and the corresponding 2,3-alkanediol as the second linear alkanediol, for example 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or 1,2-heptanediol and 2,3-heptanediol, or 1,2-octanediol and 2,3-octanediol, or 1,2-nonanediol and 2,3-nonanediol, or 1,2-decanediol and 2,2-decanediol, or 1,2-undecanediol and 2,3-undecanediol, or 1,2-dodecanediol and 2,3-dodecanediol, or 1,2-tridecanediol and 2,3-tridecanediol, wherein the first linear alkanediol and the second linear alkanediol are present in a ratio in the range of 50:50 to 99 .9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 8 0:20 to 98:2, or even more preferably in a ratio in the range of 90:10 to 95:5. Similarly, in the said mixture, the ratio of the first linear alkanediol to the second alkanediol
[0195] or the range of the said ratio, applies.
[0196] With these mixing ratios, the mixture mentioned above is described and demonstrated in the experimental part, and as shown, exhibits synergistically enhanced activity when directly compared to the corresponding individual substances, and can significantly reduce the concentration of colony -forming units.
[0197] In a more advantageous variant according to the second aspect of the invention, as the first linear alkanediol, 2,3-alkanediol, and as the second linear alkanediol, a mixture containing the corresponding 1,2 -alkanediol, for example 2,3-pentanediol and 1,2-pentanediol, or 2,3-hexanediol and 1,2-hexanediol, or 2,3-heptanediol and 1,2-heptanediol, or 2,3-octanediol and 1,2-octanediol, or 2,3-nonanediol and 1,2-nonanediol, or 2,3-decanediol and 1,2-decanediol, or 2,3-undecanediol and 1,2-undecenaediol, or 2,3-dodecanediol and 1,2-dodecanediol, or In a mixture containing 2,3-tridecanediol and 1,2-tridecanediol, the first linear alkanediol and the second linear alkanediol are present in a ratio in the range of 50:50 to 99 .9:0.1, preferably in a ratio in the range of 75:25 to 99:1, and a ratio in the range of 8 0:20 to 98:2 is more preferred, or a ratio in the range of 90:10 to 95:5 is even more preferred.
[0198] Similarly, for the said mixture, the ratio of the first linear alkanediol: the second alkanediol or the range of the above ratios applies.
[0199] With these mixing ratios, the mixture mentioned above exhibits a synergistically enhanced activity as described and demonstrated in the experimental part, and can significantly reduce the concentration of colony-forming units when directly compared to the corresponding individual substances. -forming unit concentration can be significantly reduced.
[0200] A preferred variant according to the second aspect of the invention is a mixture comprising 1, 2 - hexanediol as the first linear alkanediol and 2,3 - octanediol as the second linear alkanediol, or a mixture comprising 1,2 - octanediol as the first linear alkanediol and 2,3 - hexanediol as the second linear alkanediol, or a mixture comprising 1,2 - octanediol as the first linear alkanediol and 2,3 - heptanediol as the second linear alkanediol, also in a ratio ranging from 50:50 to 99.9:0.1, preferably from 75:25 to 99:1, more preferably from 80:20 to 98:2, or even more preferably from 90:10 to 95: ol, and 2,3 - hexanediol as the second linear alkanediol, or a mixture comprising 1,2 - octanediol as the first linear alkanediol and 2,3 - heptanediol as the second linear alkanediol, also in a ratio ranging from 50:50 to 99.9:0.1, preferably from 75:25 to 99:1, more preferably from 80:20 to 98:2, or even more preferably from 90:10 to 95: 5. enclosing, preferably in a ratio ranging from 75:25 to 99:1, more preferably from 80:20 to 98:2, or even more preferably from 90:10 to 95: 5 is even more preferred.
[0201] Similarly, for said mixture, the ratio of the first linear alkanediol:the second alkanediol or the range of said ratios applies.
[0202] With these mixing ratios, the mixture mentioned above exhibits a synergistically enhanced activity as described and demonstrated in the experimental part, and can significantly reduce the concentration of colony-forming units when directly compared to the corresponding individual substances. -forming unit concentration can be significantly reduced.
[0203] In a further advantageous modification according to the second aspect of the present invention, the mixture comprises a first linear alkanediol and a second linear alkanediol, for example 1,2-pentanediol and 2,3-hexanediol, or 1,2-pentanediol and 1,2-heptanediol, or 1,2-pentanediol and 2,3-heptanediol, or 1,2-pentanediol and 2,3-octanediol, or 1,2-pentanediol and 1,2-nonanediol, or 1,2-pentanediol and 2,3-nonanediol, and the mixture the first linear alkanediol and the second linear alkanediol are present in a ratio in the range of 50:50 to 9 9.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, a ratio in the range of 80:20 to 98:2 is more preferred, or a ratio in the range of 90:10 to 95:5 is even more preferred.
[0204] Similarly, for the said mixture, the ratio of the first linear alkanediol:the second alkanediol or the range of the said ratio applies.
[0205] Due to these mixing ratios, the mixture mentioned above shows a synergistically enhanced activity when directly compared with the corresponding individual substances, as described and demonstrated in the experimental part, and can significantly reduce the concentration of colony forming units.
[0206] A particularly preferred modification according to the second aspect of the present invention is, as the first linear alkanediol, 1,2-heptanediol, and as the second linear alkanediol, a mixture comprising 2,3-octane diol, or as the first linear alkanediol, 1,2-heptane As the diol and the second linear alkanediol, a mixture containing 1,2-nonanediol, or as the first linear alkanediol, 1,2-heptanediol and as the second linear alkanediol, a mixture containing 2,3-nonanediol are also included. The first linear alkanediol and the second linear alkanediol are present in a ratio in the range of 50:50 to 99.9:0.1, preferably in a ratio in the range of 75:25 to 99:1, more preferably in a ratio in the range of 80:20 to 98:2, or even more preferably in a ratio in the range of 90:10 to 95:5. Similarly, for the said mixture, the ratio of the first linear alkanediol to the second alkanediol or the range of the said ratio applies. Due to these mixing ratios, the mixtures mentioned above exhibit synergistically enhanced activity when directly compared to the corresponding individual substances, as described and demonstrated in the experimental part, and it is possible to significantly reduce the concentration of colony-forming units. Alkanediols can be obtained synthetically from petrochemical or other fossil fuel sources by known methods, such as the bis-hydroxylation of olefins, hydrolysis from epoxides, or various chemical conversions, or from bio-based raw materials by fermentation, or by catalytic synthesis from bio-based natural and renewable raw materials, such as biomass, as described in US2019 / 0241491A1 and US2020 / 0189995A1. The alkanediols used according to the present invention are of petrochemical origin as well as bio-based natural
[0207]
[0208]
[0209] It contains alkanediols derived from natural and renewable raw materials. Preferably, the alkanediol is from a bio-based source and is thus a bio-alkanediol .
[0210] The compound (b) of the cosmetic or pharmaceutical composition according to the first or second aspect of the present invention is used in a wide range of cosmetics, personal care products or pharmaceuticals to perform various functions, such as increasing viscosity, emulsification (retention of mixed components), generation of a protective film or barrier, and overall resulting in a product with a "smoother" or more moisturized, smoother or more comfortable feel touch:
[0211] Thickening agents: - Aqueous formulations are inherently dilute, and polymers are used to thicken them or turn them into gels . When used to increase the concentration of products such as shampoos, conditioners, creams and lotions, for example, the formulation becomes more luxurious, smooth and creamy to the touch . - Natural polymers such as starch, xanthan or guar gum, carrageenan, alginate, polysaccharide, pectin, gelatin, agar, and cellulose derivatives can be used for this purpose. For example, corn starch is often used as a thickening agent in personal care products along with similar starches and gums . - On the synthetic side, polyacrylate derivatives and polyacrylamide polymers are the most widespread for this purpose. These polymers, for example, enable alcohol hand gels to remain "gelled" so that they can be carried around without leaking They make the hair color product thick so that the color stays in place where it is applied and does not drip down. . - More recent developments include combining hydrophobic (water-resistant) and hydrophilic (hydrophilic) polymers in a "copolymer" that stabilizes the product, like sunscreen, so that it does not thin out under high heat. Structuring agents: .
[0212] Structuring agents: - Structuring agents add rigidity; these include natural and synthetic waxes, lanolin, long-chain aliphatic alcohols, and triglycerides. The popular component poly-α-olefin adds structure without a sticky feel and is used in products such as eyeshadow and lip products. Glycol stearate opacifies the product and adds a pearlescent effect. - One of the latest innovations in cosmetics with polymers is the concept of "3D makeup printing", which allows consumers to create their own custom color makeup. - Water resistance / sweat resistance / long-lasting - Film-forming polymers are important for imparting water resistance and sweat resistance benefits to sunscreens so that families can enjoy a day at the beach. - Polyurethane forms a strong film and is used in nail products and waterproof mascaras to make them long-lasting.
[0213] Hair styling products: - Polymers in hair products include natural substances such as polysaccharides, which include starch and cellulose derivatives, natural gums, and hydrolyzed proteins. Hair-friendly synthetic polymers include polyvinylpyrrolidone and acetate, polyvinylamide , polyacrylate and polymethacrylate, polyurethane and silicone. - The polymers assist in controlling hairstyles under strong winds or humid conditions, minimizing frizz and fly-aways, and providing consumers with options for the finish, such as a crisp hold or a soft natural feel. These are available in sprays, lotions, gels and foams.
[0214] Delivery system: - The polymers can serve as delivery systems for active ingredients in cosmetics, such as antioxidants and antimicrobial agents. The polymer "carrier" can physically trap the active ingredient and preserve its biological stability, or the components can be chemically incorporated into the polymer when reacted with water (these are the same techniques used in pharmaceuticals to enable controlled release of drugs). - Salicylic acid, used in over-the-counter anti-acne products, is an example of a personal care product component that can be delivered this way. Another use is the encapsulation of components, such as vitamins and peptides, that can be made to work when applied to hair and skin during use.
[0215] Humectants & conditioners: - In cosmetics, hyaluronic acid is used as a humectant mainly for its property of retaining water on the skin surface. This is to modify the viscosity of the formulation and when applied to the skin It is also used to create a good sensory feeling when administered subcutaneously for aesthetic medicine. - Conditioning polymers deposit on, adhere to, or are absorbed by the proteins of the skin and hair. These improve the feel of the skin and the manageability of the hair, reduce static electricity, and make the skin and hair softer and smoother. Examples include polyquaternium-6, polyquaternium-7, and polyquaternium-11.
[0216] Each biopolymer, which is a natural polymer, is defined in the context of the present invention as a polymer that is non-petrochemical-derived, i.e., of natural origin or from natural raw materials, or produced by fermentation, while synthetic polymers are derived from petroleum. Proteins, sugars, starches, and carbohydrates are some examples of natural polymers. Natural polymers or biopolymers are attracting great interest due to their biocompatibility, non-toxicity, renewability, and mild processing conditions. These polymers are enzymatically or non-enzymatically degradable in vivo and can be metabolized and excreted via normal physiological pathways.
[0217] The natural polymer constituents according to the first and second aspects of the present invention are a diverse group of compounds covering, for example, gums, polysaccharides, proteins, and the like.
[0218] The natural polymer constituents in the cosmetic or pharmaceutical compositions according to the first and second aspects of the present invention are preferably natural gums, starches, celluloses, and their derivatives, hyaluronic acid, etc.
[0219] acid, etc. phosphoric acid, pectin, collagen, gelatin, chitosan, keratin, hectorite, and selected from the group consisting of mixtures of two or more of the foregoing natural polymers.
[0220] Natural gums are also; - preferably natural gums obtained from seaweeds, especially agar, algin (algic acid) or carrageenan (cara geenan); - preferably natural gums obtained from non - marine plant resources, especially gum arabic (Acacia senegal gum), ghatti gum, tragacanth gum, karaya gum, guar gum, locust bean gum, beta - glucan, damar gum, galactomannan, glucomannan, psyllium seed coat or tara gum; - preferably natural gums produced by bacterial fermentation, especially gellan gum, xanthan gum or sclerotium gum; and selected from the group consisting of mixtures of two or more of the foregoing natural gums.
[0221] Starch is also wheat starch, rice starch, maize starch, zea may s (corn) starch, tapioca starch, potato starch, cassava starch, chestnut starch, arrowroot starch, aracacha starch, banana starch , barley starch, panoko starch, buckwheat starch, kannad starch, taro starch, katakuri starch, kudzu starch, malanga starch, awad starch, rye starch , okra starch, Polynesian arrowroot starch, sago starch, sorghum starch, sweet potato starch, lime starch, taro starch, kuri starch, shirogwa starch, yam starch, bean starch, pea starch, physically , consisting of chemically or enzymatically modified starch, and a mixture of two or more of the aforementioned starches selected from the group consisting of
[0222] Cellulose or its derivatives include microcrystalline cellulose, cellulose gum, hydroxyethyl cellulose, carboxymethyl-cellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, and a mixture of two or more of the aforementioned cellulose or derivatives selected from the group consisting of
[0223] The natural polymers described above can be used as a single component or in a mixture with two or more different natural polymers described above.
[0224] In a preferred variant, the natural polymer of the cosmetic or pharmaceutical composition of the present invention is agar, algin (alginic acid), carrageenan, gum arabic (Acacia senegal gum), guar gum , xanthan gum, sclerotium gum, microcrystalline cellulose, cellulose gum, zea mays (corn) starch, tapioca starch, pectin, hectorite, and a natural polymer selected from the group consisting of a mixture of two or more of the aforementioned natural polymers .
[0225] In a more preferred variant, the natural polymer of the cosmetic or pharmaceutical composition of the present invention is agar, car rageenan, gum arabic (Acacia senegal gum), guar gum, sclerotium gum , microcrystalline cellulose, cellulose gum, zea mays (corn) starch, ta pioca starch, pectin, hectorite, and a natural polymer selected from the group consisting of a mixture of two or more of the aforementioned natural polymers .
[0226] In a particularly preferred variant, the natural polymer of the cosmetic or pharmaceutical composition of the invention is carrageenan nan, guar gum, xanthan gum, microcrystalline cellulose, cellulose gum, zea ma ys (corn) starch, and a natural polymer selected from the group consisting of two or more of the aforementioned natural polymers .
[0227] In a particularly advantageous variant, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises one of the following combinations of constituents (a) and (b): · 1,2-pentanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerothium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-hexanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerothium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · · 1,2 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - octanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - nonanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or Pectin and / or hectorite; or · 1,2 - Decanediol and one or more of the following natural polymers: Agar and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2 - Undecanediol and one or more of the following natural polymers: Agar and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2 - Dodecanediol and one or more of the following natural polymers: Agar and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-tridecanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite. · 2,3-pentanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3-hexanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - heptanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - octanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - nonanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or Pullulan and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - decanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - undecanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - dodecanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3-tridecanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-heptanediol in combination with 2,3-heptanediol and one or more of the following natural po lymers: agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - octanediol, 1,2 - nonanediol, 1,2 - decanediol, 1,2 - undecanediol, 1, 2 - dodecanediol or 1,2 - tridecanediol, in combination with one or more of 1,2 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - pentanediol, 2,3 - hexanediol, 2,3 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2,3 - dodecanediol, or 2,3 - tridecanediol in combination with one or more of 1,2 - heptanediol and one or more of the following natural polymers: one or more of agar, and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2-pentanediol in combination with 2,3-pentanediol and one or more of the following natural polymers: agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or pectin and / or hectorite; or · 1,2-hexanediol in combination with 2,3-hexanediol and one or more of the following natural polymers: agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or pectin and / or hectorite; or · 1,2-octanediol in combination with 2,3-octanediol and one or more of the following natural polymers: agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or agar and / or algin (alginate) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea mays (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or Pullulan and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-Nonanediol combined with 2,3-nonanediol and one or more of the following natural polymers : agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-Decanediol combined with 2,3-decanediol and one or more of the following natural polymers : agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-Undecanediol combined with 2,3-undecanediol and one or more of the following natural One or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-dodecanediol in combination with 2,3-dodecanediol and one or more of the following natural po lymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-tridecanediol in combination with 2,3-tridecanediol and one or more of the following na tural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - hexanediol and 2,3 - octanediol with one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - octanediol and 2,3 - hexanediol with one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - octanediol and 2,3 - heptanediol with one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - hexanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 1,2 - heptanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - heptanediol with one or more of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - octanediol with one or more of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 1,2 - nonanediol with one or more of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-pentanediol and 2,3-nonanediol with one of the following natural polymers or more than one: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-heptanediol and 1,2-octanediol with one or more than one of the following: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-heptanediol and 2,3-octanediol with one or more than one of the following: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 1,2 - nonanediol and one or more of the following natural polymers : Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 2,3 - nonanediol and one or more of the following natural polymers : Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite.
[0228] In the cosmetic or pharmaceutical composition according to the first or second aspect of the present invention, the more preferred combinations of the constituent components (a) and (b) are: · 1,2 - heptanediol and one or more of the following natural polymers: · 1,2 - heptanediol and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - pentanediol and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - hexanediol and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or agar and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea may (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or Pullulan and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - octanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - nonanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - decanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - undecanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - dodecanediol and one or more of the following natural polymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·2,3-tridecanediol and one or more of the following natural polymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·1,2-heptanediol combined with 2,3-heptanediol and one or more of the following natural po lymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1, 2-dodecanediol or 1,2-tridecanediol, in combination with one or more of 1,2-heptanediol, and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3 -undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol in combination with one or more of 1,2-heptanediol, and one or more of the following natural polymers: one agar and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-pentanediol combined with 2,3-pentanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-hexanediol combined with 2,3-hexanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-octanediol combined with 2,3-octanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-nonanediol combined with 2,3-nonanediol, and one or more of the following natural polymers : agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-decanediol combined with 2,3-decanediol, and one or more of the following natural polymers : agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-undecanediol in combination with 2,3-undecanediol and one or more of the following natural polymers: agar and / or algin (algic acid) and / or carrageenan and / or arabic gum (Acacia Senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or · 1,2-dodecanediol in combination with 2,3-dodecanediol and one or more of the following natural polymers: agar and / or algin (algic acid) and / or carrageenan and / or arabic gum (Acacia Senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or · 1,2-tridecanediol in combination with 2,3-tridecanediol and one or more of the following natural polymers: agar and / or algin (algic acid) and / or carrageenan and / or arabic gum (Acacia Senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - hexanediol and 2,3 - octanediol with one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - octanediol and 2,3 - hexanediol with one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - octanediol and 2,3 - heptanediol with one or more of the following natural polymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - hexanediol and one or more of the following natural polymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 1,2 - heptanediol and one or more of the following natural polymers: Agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2 - pentanediol and 2,3 - heptanediol and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2 - pentanediol and 2,3 - octanediol and one or more of the following natural polymers: agar and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin and / or hectorite; or · 1,2 - pentanediol and 1,2 - nonanediol and one of the following natural polymers or more: agar and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or pullulan and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - nonanediol and one of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 1,2 - octanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (maize) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 2,3 - octanediol and one or more of the following natural polymers: · 1,2 - heptanediol and 2,3 - octanediol and one Or a plurality: agar, and / or algin (algic acid), and / or carrageenan, and / or gum arabic (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·1,2 - heptanediol and 1,2 - nonanediol and one of the following natural polymers or a plurality: agar, and / or algin (algic acid), and / or carrageenan, and / or gum arabic (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·1,2 - heptanediol and 2,3 - nonanediol and one of the following natural polymers or a plurality: agar, and / or algin (algic acid), and / or carrageenan, and / or gum arabic (Acacia Senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite.
[0229] Components in the cosmetic or pharmaceutical composition according to the first or second aspect of the present invention (a) and (b) The most preferred combinations are: · 1,2 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 2,3 - octanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or · 2,3-nonanediol and one or more of the following natural polymers: agar and / or algin (algic acid) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or · 2,3-undecanediol and one or more of the following natural polymers: agar and / or algin (algic acid) and / or carrageenan and / or gum arabic (Acacia senegal gum) and / or guar gum and / or xanthan gum and / or sclerotium gum and / or microcrystalline cellulose and / or cellulose gum and / or zea ma ys (corn) starch and / or tapioca starch and / or pectin and / or hectorite; or · 1,2-pentanediol in combination with 2,3-pentanediol and the following natural po One or more remmers: Agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·1,2 - hexanediol combined with 2,3 - hexanediol, and one or more of the following natural polymers: One or more remmers: Agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or ·1,2 - octanediol combined with 2,3 - octanediol, and one or more of the following natural polymers: One or more remmers: Agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-nonanediol combined with 2,3-nonanediol and one or more of the following natural polymers : agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-decanediol combined with 2,3-decanediol and one or more of the following natural polymers : agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-hexanediol and 2,3-octanediol and one or more of the following natural polymers : agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-octanediol and 2,3-hexanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2-octanediol and 2,3-heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - Pentanediol and 2,3 - hexanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - Pentanediol and 1,2 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - Pentanediol and 2,3 - heptanediol and one or more of the following natural polymers: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - octanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 1,2 - nonanediol and one or more of the following: agar, and / or algin (algic acid), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or is microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - pentanediol and 2,3 - nonanediol and one or more of the following: agar, and / or algin (algic acid), and / or carrageenan, and / or agar and / or gum arabic (Acacia senegal gum), and / or guar gum, and and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 1,2 - octanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 2,3 - octanediol and one or more of the following natural polymers: agar, and / or algin (algic acid), and / or carrageenan, and / or gum arabic (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 1,2 - nonanediol and one of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite; or · 1,2 - heptanediol and 2,3 - nonanediol and one of the following natural polymers or more: agar, and / or algin (alginate), and / or carrageenan, and / or arabic gum (Acacia senegal gum), and / or guar gum, and / or xanthan gum, and / or sclerotium gum, and / or microcrystalline cellulose, and / or cellulose gum, and / or zea ma ys (corn) starch, and / or tapioca starch, and / or pectin, and / or hectorite.
[0230] The addition of 1,2 - heptanediol or 2,3 - alkanediol, especially 2,3 - heptanediol, 2,3 - octanediol, 2,3 - nonanediol and 2,3 - undecanediol results in excellent activity in stabilizing the natural polymer solution for preservation by reducing the microbial load. This effect is demonstrated by the following examples: This effect is demonstrated by the following examples:
[0231] When 1,2 - heptanediol is added to a cosmetic or pharmaceutical preparation containing a natural polymer, or to a home care product, a greater reduction in the microbial load can be obtained compared to 1,2 - pentanediol and 1,2 - hexanediol.
[0232] This effect is also achieved by the addition of 2,3 - heptanediol and other 2,3 - alkanediols, such as 2,3 - pentanediol, 2,3 - hexanediol, 2,3 - octanediol, 2,3 - nonanediol, 2,3 - decanediol, 2,3 - undecanediol, 2,3 - dodecanediol and 2,3 - tridecanediol to a cosmetic or pharmaceutical preparation containing a natural polymer, or to a home care product.
[0233] Compared to the use of pure 1,2 - alkanediols, such as 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, the above - mentioned mixture containing the first linear alkanediol and the second linear alkanediol according to the second aspect of the present invention has a synergistically enhanced effect, that is, the mixture significantly reduces the microbial load in a cosmetic or pharmaceutical preparation containing a natural polymer, or in a home care product, by synergistic means as compared to each single alkanediol substance. This effect or action is achieved by 1,2 - pentanediol and 2,3 - pentanediol, 1,2 - hexanediol and 2,3 - hexanediol, preferably 1,2 - heptanediol and 2,3 - heptanediol, preferably 1,2 - octanediol and 2,3 - octanediol, preferably 1,2 - nonanediol and 2,3 - nonanediol, 1,2 - decanediol and and 2,3-decanediol, 1,2-undecanediol and 2,3-decanediol l, 1,2-dodecanediol and 2,3-dodecanediol and 1,2-trideca ol and 2,3-tridecanediol, which is particularly remarkable in the homogeneous mixture.
[0234] Furthermore, when the corresponding 2,3-alkanediol is miscible, for example, a solid 1,2-alkanediol having a carbon chain of 8 or more carbon atoms can be dissolved, and thus these mixtures become liquid mixtures, thereby facilitating the incorporation of such solid 1,2-alkanediols into semi-finished or final products, and increasing the availability of the product has benefits. Furthermore, in the emulsion, the dissolved 1,2-alkanediol remains in the aqueous phase and can directly exhibit antimicrobial activity at the location where microbial contamination occurs, and does not tend to migrate into the oil phase.
[0235] Also, a hetero mixture containing, for example, 1,2-hexanediol and 2,3-octanediol, or a mixture containing 1,2-octanediol and 2,3-hexanediol , or a mixture containing 1,2-octanediol and 2,3-heptanediol , an alkanediol mixture containing different first linear alkanediols and second linear alkanediols (secon d linear) shows a synergistically enhanced effect of reducing the microbial load in cosmetic or pharmaceutical preparations containing natural polymers, or in home care products. d linear) shows a synergistically enhanced effect of reducing the microbial load in cosmetic or pharmaceutical preparations containing natural polymers, or in home care products, as described in detail above. The stabilization of microorganisms is achieved without decomposition and deterioration of the microorganisms, in cosmetic or pharmaceutical compositions, or also
[0236] in home care products. It enables the storage of home care products, thereby extending the storage period.
[0237] Furthermore, the alkandiol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol enables the low-temperature preparation of home care products as described above, i.e., heating during preparation is no longer essential. Furthermore, the above alkandiol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol improves the wettability of natural polymers. Without adding such an alkandiol mixture, natural polymer formulations may separate. Furthermore, the above alkandiol mixture containing 1,2-alkanediol and the corresponding 2,3-alkanediol prevents the polymer aggregation of natural polymers.
[0238] Therefore, due to the above properties of the alkandiol mixture containing 1,2-alkanediol and each of the above-mentioned 2,3-alkanediols, the processability in the formulation is improved.
[0239] Therefore, when an active antimicrobial agent mixture is combined to improve the processability in the formulation while maintaining the antimicrobial effect, a good balance can be achieved.
[0240] From the perspective of a comprehensive research on the activity of individual alkandiols, especially mixtures of alkandiols, such as 1,2-pentanediol and 2,3-pentanediol, or 1,2-hexanediol and 2,3-hexanediol, or preferably 1,2-heptanediol and 2,3-heptanediol, or preferably 1,2-octanediol and 2,3-octanediol, 2,3-octanediol and 2,3-octanediol, or preferably 1,2-nonanediol. and that 2,3-nonanediol and 2,3-nonanediol exhibit synergistic activity, and that the mixture over the corresponding 1,2-alkanediols or 2,3-alkanediols, It was surprising that all the proposed solutions according to the invention had a CFU value of A reduction (CFU=colony forming unit number) can be achieved.
[0241] At least one alkanediol or a mixture of an alkanediol and a natural polymer The particular combinations defined above may be combined with one or more further It can be combined with component (c).
[0242] In order to further reduce the microbial load, a cosmetic or pharmaceutical composition as defined herein may be used. The composition, or home care product, is advantageously combined with at least one antimicrobial agent. can be done.
[0243] An antimicrobial agent is a substance that kills or slows the growth of microorganisms. Among these are antibacterial, antiviral, antifungal, and antiparasitic agents. This combination provides protection against microbial degradation and deterioration of cosmetic or pharmaceutical compositions, especially during storage. This provides highly reliable protection.
[0244] Antimicrobial agents relevant to the present invention include caprylhydroxamic acid, o-cymen-5-ol, Isopropylparaben, Capryloylglycine, Phenylpropanol, Tropolone, Co Coil arginine ethyl PCA, 2-methyl 5-cyclohexyl pentanol, phenoxy Cetyl alcohol, disodium EDTA, methylparaben and its salts, sodium benzoate M, benzyl alcohol, potassium sorbate, benzyl salicylate, propyl paraben , methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin , butyl paraben, ethyl paraben, sodium propyl paraben, DMDM hydantoin ne, hydroxyethoxyphenyl butanone, hydroxyethoxyphenyl butanol, i taconic acid and its salts, octopirox, caprylic acid propanediol, climazole , 4-hydroxyacetophenone, dehydroacetic acid, propiolyl butylcarbamate iodide , salicylic acid, chlorphenesin, isobutyl paraben, sodium ethyl paraben, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic acid glyceryl, sodium phytate or phytic acid, sodium levulinate or levu linic acid and its esters, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, ca pryl phosphate glyceryl, sorbitan caprylate, tetrasodium glutamate diacetate, ethy lenediamine disuccinate trisodium, sodium lactate, undecylenoyl glycine, thym ol, 1,3-propanediol, 4-hydroxybenzoic acid and its salts and esters , N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 2,4, 4'-trichloro-2'-hydroxy-diphenyl ether (triclosan), 4-chlo ro-3,5-dimethyl-phenol, 2,2'-methylenebis(6-bromo-4-chloro phenol), 3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4- Chloro-phenol, 3-(4-chlorophenoxy)-1,2-propanediol, 3- Iodo-2-propynyl butylcarbamate, 3,4,4’-trichlorocarbanilide( TTC), antibacterial fragrance, thymol, thyme oil, eugenol, clove oil, menth -ol, mint oil, glycerin monocaprylate, glycerin monocaprate, monolaurin acid glycerin (GML), diglycerin monocaprate (DMC), N-alkyl salicylamide, for example, n-octyl salicylamide or n-decyl salicylamide, de hydroacetic acid, 4-methylbenzyl alcohol, Frambinon, xylyl caprylate , 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate , 3-hydroxypropyl 2-hydroxybenzoate, and two or more of the aforementioned antimicrobial agents selected from the group consisting of mixtures.
[0245] In a preferred variant according to the invention, the antimicrobial agent is phenoxyethanol, disodium EDTA , methylparaben and its salts, sodium benzoate, benzyl alcohol, potassi um sorbate, benzyl salicylate, propylparaben, methylchloroisothiazoli none, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethylpar aben, sodium propylparaben, DMDM hydantoin, hydroxyethoxyphen ylbutanone, hydroxyethoxyphenylbutanol, itaconic acid and its salts, oct irox, propanediol caprylate, climbazole, 4-hydroxyacetophen one, dehydroacetic acid, propynyl iodide butylcarbamate, salicylic acid, chlorphen nesin, isobutylparaben, sodium ethylparaben, diazolidinyl urea, diazo Ricinyl urea, farnesol, bisabolol, glyceryl caprylate, sodium phytic acid or phytic acid, sodium levulinate or levulinic acid and its esters, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate TEA salicylate, phenethyl alcohol, glyceryl caprylate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediaminedisuccinate sodium lactate, Frambinon, xylyl caprylate, 3-hydroxypropyl benzoate, 3-hydroxypropyl anisate, 2-hydroxy 3-hydroxypropyl benzoate and a mixture of two or more of the aforementioned antimicrobial agents selected from the group consisting of.
[0246] In the most preferred variant according to the invention, the antimicrobial agent is phenoxyethanol, EDTA disodium, methylparaben and its salts, sodium benzoate, benzyl alcohol , potassium sorbate, benzyl salicylate, propylparaben, methylchloroisothia zolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben, ethyl paraben, sodium propylparaben, DMDM hydantoin, hydroxyethoxy phenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid and its salts, octopirox, propanediol caprylate, climbazole, 4-hydroxyacet tophenone, dehydroacetic acid, Frambinon, xylyl caprylate, 3- hydroxypropyl benzoate, 3-hydroxypropyl anisate, 2-hydroxy 3-hydroxypropyl benzoate and a mixture of two or more of the aforementioned antimicrobial agents selected from the group consisting of
[0247] The cosmetics or pharmaceuticals defined herein, in particular dermatological compositions, preferably are based on a carrier comprising at least one oil phase. Thus, oils, oil-in-water and water-in-oil em ulsions and the like are suitable. However, preparations based on water or water / alcohol or water / glycol are also possible, or even more preferred.
[0248] Suitable oil phases or oil constituents in the cosmetic or pharmaceutical composition according to the invention are, for example, vegetable oils, hydrocarbons, aliphatic alcohols, fatty acid esters, liquid UV filters or mixtures of two or more of the aforementioned oil constituents.
[0249] The oil phase or oil constituent in the cosmetic or pharmaceutical composition is preferably a vegetable oil, and even more preferably a liquid vegetable oil. This can advantageously also be a mixture comprising two or more vegetable oil constituents, in particular a liquid vegetable oil mixture.
[0250] Vegetable oils or vegetable fats are also oils extracted from seeds or, less commonly, from other parts of fruits. Like animal fats, vegetable oils are mixtures of triglycerides. Soybean oil, rapeseed oil and cocoa butter are examples of vegetable oils from seeds. Olive oil, palm oil and rice bran oil are examples of oils from other parts of fruits. In common use, vegetable oils or vegetable fats can refer exclusively to vegetable fats that are liquid at room temperature or at skin temperature of 35 to 37 °C. Vegetable oils are usually edible. The term "vegetable oil" also includes unsaturated vegetable oils. Unsaturated oils or vegetable oils are partially hydrogenated.
[0251] hydrogenated. or through complete "hydrogenation", it can be converted into oils with higher melting points. The hydrogenation process is carried out at high temperature and high pressure with hydrogen in the presence of a catalyst, typically a powdered nickel compound, accompanied by "spraying" of the oil. Since each carbon-carbon double bond is chemically reduced to a single bond, two hydrogen atoms each form a single bond with two carbon atoms. The elimination of the double bond by adding hydrogen atoms is called saturation. As the degree of saturation increases, the oil progresses towards complete hydrogenation. The oil can be hydrogenated to increase its resistance to rancidity (oxidation) or to change its physical properties. As the degree of saturation increases, the viscosity and melting point of the oil increase.
[0252] In a preferred variant, the vegetable oil is Persea Gratissima (avocado oil), Abies Alba seed oil, Acacia Victoriae seed oil, Actini dia Chinensis (kiwifruit) seed oil, Amaranthus Hyp ochondriacus seed oil, Arachis Hypogaea (peanut) oil 、Astrocaryum Murumuru seed butter, Astrocaryum Tucuma seed butter, Astrocaryum Tucuma seed oil, Astroc aryum Vulgare fruit oil, Astrocaryum Vulgare kernel oil, A vena Sativa (rapeseed) kernel oil, Brassica Alba seed oil, Br assica Campestris (rape) seed oil, Butyrospermum Parkii (shea) butter, Butyrospermum Parkii (shea) oil, Calendula Officinalis seed oil, Calophyllum Ino phyllum seed oil, Calophyllum Tacamahaca seed oil, Cam ellia Oleifera seed oil, Camellia Reticulata seed oil , Camellia Sinensis seed oil, Cannabis Sativa seed oil , Cannabis Sativa seed / stem oil, canola oil, Carthamus T inctorius (safflower) seed oil, Chlorella Vulgaris oil, Citrullus Lanatus (watermelon) seed oil, Citrus Auranti folia (lime) seed oil, Citrus Aurantium Dulcis (or ange) seed oil, Citrus Grandis (grapefruit) seed oil, Cocos Nucifera (coconut) oil, Cocos Nucifera (coconut) seed butter, Coffea Arabica (coffee) seed oil, chlorella oil (biotechnology), Cory lus Americana (hazelnut) seed oil, Corylus Avella na (hazelnut) seed oil, Cucumis Melo (melon) seed oil, Cucu mis Sativus (cucumber) seed oil, Cucurbita Pepo (pumpkin ) seed oil, Elaeis Guineensis (palm) oil, Elaeis (palm) fruit oil, Glycine Soja (soybean) oil, Gossypium Herbace um (cotton) seed oil, Gossypium Hirsutum (cotton) seed oil, Helian thus Annuus (sunflower) seed oil, Macadamia Integrifo lia seed oil, Macadamia Ternifolia seed oil, Mangifera Indica (mango) seed butter, Mangifera Indica (mango - ) Seed oil, Melissa Officinalis seed oil, microalgae oil, Morin ga Oleifera seed oil, Moringa Peregrina seed oil, Oeno thera Biennis (evening primrose) oil, Olea Europaea (olive) - ) Fruit oil, orus oil, Orbignya Oleifera seed oil, Orbignya Speciosa kernel oil, Oryza Sativa (rice) bran / germ oil, Oryz a Sativa (rice) bran oil, Oryza Sativa (rice) germ oil, Ory za Sativa (rice) lipids, Oryza Sativa (rice) seed oil, Papa ver Somniferum seed oil, Passiflora Edulis seed oil, P ersea Gratissima (avocado) butter, Persea Gratiss ima (avocado) oil, Prunus Amygdalus Dulcis (sweet a - mond) oil, Prunus Armeniaca (apricot) kernel oil, Prunus Pe rsica (peach) kernel oil, Punica Granatum seed oil, Pyrus Mal us (apple) seed oil, poultry (linoleic acid / capronic acid / caprylic acid / capric acid) glyceryl (plural available), Ricinus Communis (castor) seed oil, Rosa Canina fruit oil, Rosa Moschata seed oil, Rubus Idaeus (raspberry) seed oil, Sesamum Indicum (sesame) seed butter, soybean glyceride, Theobroma Cacao (cocoa) seed butter, Theobro ma Grandiflorum seed butter, Triticum Vulgare (wheat) Wheat Bran Lipid, Triticum Vulgare (Wheat) Germ Oil, Vitis Vinifera (Grape) Seed Oil, Zea Mays (Corn) Germ Oil, and selected from the group consisting of Zea Mays (Corn) Oil.
[0253] In a detailed preferred variant, the cosmetic or pharmaceutical composition according to the first or second aspect of the invention comprises, as an oil constituent, caprylic capric triglyceride, Helian thus Annuus (Sunflower) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Olea Europaea (Olive) Fruit Oil, Argania spinosa Kernel Oil (Argan Oil), Prunus Amygdalus Dulci s (Sweet Almond) Oil, Persea Gratissima (Avocado Oil), B utyrospermum Parkii (Shea) Butter, Coconut Oil, The obroma Cacao (Cocoa) Seed Butter, and a vegetable oil selected from the group consisting of a mixture of two or more of the aforementioned vegetable oils. The vegetable oil can be used as a single constituent or in a mixture with one or more further different vegetable oils (plural possible) as described above.
[0254] Hydrocarbons (mineral oils) are generally organic compounds consisting entirely of hydrogen and carbon. IU PAC nomenclature or as defined by organic chemistry, the classification of hydrocarbons is as follows : 1. Saturated hydrocarbons are the simplest of the hydrocarbon species. These are composed entirely of single bonds and are saturated with hydrogen. The formula for acyclic saturated hydrocarbons (i.e., alkanes) is , C n H 2n+2It is. The most common form of saturated hydrocarbons is C n H 2n+2(1-r ) where r is the number of rings. Those having exactly one ring are cycloalkanes . Saturated hydrocarbons are the basis of petroleum fuels and are found as linear or branched species 2. Unsaturated hydrocarbons have one or more double or triple bonds between carbon atoms . Those having a double bond are called alkenes. Those having one double bond have the formula C n H 2n (assuming an acyclic structure). Those containing a triple bond are called alkynes . Those having one triple bond have the formula C n H 2n-2 3. Aromatic hydrocarbons, also known as arenes, are hydrocarbons having at least one aromatic ring
[0255] Hydrocarbons can be, inter alia, liquids (such as hexane and benzene), waxes or low melting point solids (such as paraffin wax and naphthalene). The term "aliphatic" refers to non-aromatic hydrocarbons. Saturated aliphatic hydrocarbons are sometimes referred to as "paraffins" . Mineral oils and waxes are mainly mixtures of saturated hydrocarbons consisting of linear, branched and cyclic structures having a carbon chain length greater than C14 . Mineral oils and waxes are chemicals prepared from naturally occurring petroleum crude oil. They consist mainly of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). Hydrocarbons have been used in skin and lip care cosmetics for decades due to their excellent skin tolerance, high protection and cleansing performance, as well as a wide range of viscosity options . In contrast to vegetable oils, mineral oils are highly stable It is non-allergenic as it is less susceptible to oxidation or rancidity.
[0256] In a preferred variant, the hydrocarbon is undecane, tridecane, mineral oil, petrolatum, squalene, isohexadecane, C7 - C8 isoparaffin, C8 - C9 isoparaffin, C9 - C11 isoparaffin, C9 - C12 isoparaffin, C9 - C13 isoparaffin, C9 - C14 isoparaffin, C9 - C16 isoparaffin, C10 - C11 isoparaffin, C10 - C12 isoparaffin, C10 - C13 isoparaffin, C11 - C12 isoparaffin, C11 - C13 isoparaffin, C11 - C14 isoparaffin, C1 2 - C14 isoparaffin, C12 - C15 isoparaffin, C12 - C20 isoparaffin, C13 - C14 isoparaffin, C13 - C16 isoparaffin, C14 - C16 isoparaffin, C15 - C19 isoparaffin, and C18 - C70 isoparaffin selected from the group consisting of. The hydrocarbon can be used as a single constituent or in a mixture with one or more further different vegetable oils (plural possible).
[0257] Aliphatic alcohols (or long-chain alcohols) are usually high molecular weight linear primary alcohols but can range from as few as 4 to 6 to 22 to 26 carbons and are derived from natural fats and oils. The exact chain length varies depending on the source. Some commercially important aliphatic alcohols are lauryl, stearyl, and oleyl alcohols. These are colorless oily liquids (when the number of carbons is small) or waxy solids, but impure samples may appear yellow. Aliphatic alcohols usually have an even number of carbon atoms and are attached to the terminal carbon It has a single alcohol group (-OH). Some are unsaturated and some are branched. Most aliphatic alcohols found in nature are found as waxes, which are esters having fatty acids and aliphatic alcohols. The long-standing sources of aliphatic alcohols are mostly various vegetable oils, which continue to be major raw materials. Alcohols are obtained from triglycerides (fatty acid triesters) that form the majority of oils. The process involves transesterifying triglycerides to obtain methyl esters, which are then hydrogenated to obtain aliphatic alcohols. Aliphatic alcohols are also prepared from petrochemical sources. In the Ziegler process, ethylene is oligomerized using triethylaluminum, followed by air oxidation. Alternatively, ethylene can be oligomerized to obtain a mixture of alkenes, which can be subjected to the hydroformylation process, from which odd-numbered aldehydes are obtained and then subsequently hydrogenated. Aliphatic alcohols are mainly used in the products of detergents and surfactants. They are also components of cosmetic solvents. They find use as co-emulsifiers, skin softeners and thickeners in cosmetics.
[0258] In a preferred variant, the aliphatic alcohol is selected from the group consisting of phenylpropanol, dimethylphenylbutanol, hexyl decanol, octyldodecanol, octyldecanol, tridecyl alcohol, isostearyl alcohol, phenylisohexanol, phenylpropanol, trimethylbenzene propanol, isoamyl alcohol, isostearyl alcohol, and isotridecyl alcohol. The aliphatic alcohol can be used as a single component or in a mixture with one or more of the above further different aliphatic alcohols (s).
[0259] Fatty acid esters are a type of ester derived from a combination of fatty acids and alcohols . When the alcohol component is glycerol, the resulting fatty acid esters can be monoglycerides, diglycerides or triglycerides. Fatty acid esters have a skin-softening conditioning effect that creates a smooth sensation. They are also added to cosmetics to dissolve highly polar active ingredients and UV absorbers. Esters of straight-chain fatty acids and lower alcohols are effective in dissolving components that are slightly soluble in oils and make the feel during application lighter. Isostearic acid, and other liquid oils having branched and unsaturated fatty acids are commonly used as skin softeners. Higher fatty acid esters and esters of higher alcohols with relatively high melting points are added to skin creams to adjust the feel of application .
[0260] In a preferred variant, the fatty acid esters are alkyl C12-C15 benzoates, glyceryl tri(capric / lauric / myristic / oleic acid), glyceryl tri(caprylic / capric acid), glyceryl tri(caprylic / capric / lauric acid), glyceryl tri(caprylic / capric / linoleic acid), glyceryl tri(caprylic / capric / myristic / stearic acid), glyceryl tri(caprylic / capric / palmitic / stearic acid), glyceryl tri(caprylic / capric / stearic acid), triglyceryl (caprylic / capric / succinic acid), caprylic capric Cetearyl hexanoate, cetearyl isononanoate, cetearyl nonanoate, coco-caprylate relate, decyl coconut fatty acid, decyl oleate, dicaprylyl carbonate, diethyl succinate 、diethylhexyl 2,6-naphthalate, diethylhexyl carbonate, dibutyl adipate 、diisopropyl adipate, dipropylheptyl carbonate, ethyl laurate, ethylhexyl isononanoate 、ethylhexyl palmitate, ethylhexyl stearate, (caprylic / capric) glyceryl, glyceryl caprylate 、glyceryl laurate, glyceryl triacetylhydroxystearate, glyceryl triacetylricinoleate 、hexyl laurate, isoamyl acetate, isoamyl coconut fatty acid, isopropyl palmitate 、isosorbide dicaprylate, isopropyl myristate, myristyl myristate, tri(oleic / linoleic) glyceryl 、tri(oleic / palmitic) glyceryl, tri(oleic / palmitic / lauric / myristic / linoleic) glyceryl 、propanediol dicaprylate, tri(ricinoleic / caproic / caprylic / capric) glyceryl, oleostearin 、oleyl erucate, tri(palmitic / stearic) glyceryl, dipropanediol (caprylic / capric) 、propylheptyl caprylate, stearyl heptanoate / caprylate stearyl, triheptanoin 、trihydroxystearin, triisononanoin, triisopalmitin, triisostearin, trilaurin 、trilinolein, trilinolenin, trimyristin, triolein, tripalmitin, tripalmitolein 、triperargonic acid, triricinoleic acid, and tristearin. The fatty acid ester is a single component selected from the group consisting of 、 、 and is selected from the group consisting of. The fatty acid ester is a single component or in admixture with one or more further different fatty acid ester(s) as described above. It can be used in
[0261] A UV filter is a compound or compounds that block or absorb ultraviolet (UV) light. It is a mixture. Excessive UV radiation can cause sunburn, photoaging and skin cancer, so Care products, such as sunscreens, are usually rated for the specific wavelengths they filter. UV classification includes UVA (320-400 nm), UVB (290-320 nm) and UV-absorbing compounds are not just sunscreens. Not only that, but also other personal care products such as lipstick, shampoo, hairspray, body wash, etc. It is also used in cosmetics, toilet soaps and insect repellents. Filters provide protection from UV radiation by absorption, reflection or scattering. Reflection and Scattering can be achieved by inorganic physical UV filters, such as titanium dioxide (TiO 2 ) and zinc oxide ( The absorption of UVB is mainly achieved by chemical UV filters known as This is achieved by using organic UV filters.
[0262] In a preferred variant, the liquid UV filter is octocrylene, octyl salicylate, phosphatidylcholine ... Mosalate, Ethylhexyl Methoxycinnamate, Isoamyl p-Methoxycinnamate, Can Farbenzalkonium methosulfate, polyacrylamide methyl benzylidene can Fur, isooctyl methoxycinnamate, ethylhexyl triazone, drometrizo Trisiloxane, Diethylhexylbutamidotriazone, 3-benzylidene camphor - 1. Octyl salicylate, ethylhexyl dimethyl PABA, bis-ethylhexyl oxy phenol methoxyphenyl triazine, polysilicone-15, diethylamino hydro xybenzoyl benzoic acid hexyl, N,N,N-trimethyl-4-(2-oxoborn -3-ylidene methyl) anilinium methyl sulfate, benzoic acid-2-hydroxy- 3,3,5-trimethylcyclohexyl ester / homosalate, 2-cyano-3,3- diphenylacrylic acid, 2-ethylhexyl ester / octocrylene, 2-ethylhex yl-4-methoxycinnamate / octinoxate, ethoxylated ethyl-4-aminobe nzoate, 2-ethylhexyl salicylate / octisalate, 2-ethylhexyl- 4-(dimethylamino)benzoate / padimate O (USAN:BAN), 2,2’ -methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3, 3-tetramethyl-butyl)phenol) / bisoctrizole, and dimethico-diethyl benzalmalonate (Dimethico-diethylbenzalmalona te) selected from the group consisting of. The aforementioned UV filter(s) can be used as a single component or in a mixture with one or more further different UV filter(s) described further below.
[0263] In addition to the oil phase or oil constituent(s) defined above, the cosmetic or pharmaceutical composition according to the invention preferably contains one or more oily substances. Suitable oily substances for forming the components of an O / W emulsion are, for example, Guerbet alcohols based on aliphatic alcohols having 6 to 18, preferably 8 to 10 carbon atoms, linear C5-C22 fatty acids and linear or branched C3-C22 fatty alcohols, esters of linear C6-C22 fatty acids with linear or branched C3-C22 fatty alcohols, esters of linear C6-C22 fatty acids with Guerbet alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with aliphatic alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with is an ester of a branched C5-C22 aliphatic alcohol or a branched C1-C13 carboxylic acid and an ester of a linear or branched C6-C22 aliphatic alcohol, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl erucate. An ester of a linear C6-C22 fatty acid and a branched alcohol, especially 2-ethylhexanol, an ester of a C18-C38 alkylhydroxycarboxylic acid and a linear or branched C6-C22 aliphatic alcohol, especially dioctyl malate, and an ester of a C18-C38 alkylhydroxycarboxylic acid and a linear or branched C6-C22 aliphatic alcohol, especially dioctyl malate, and an ester of a C18-C38 alkylhydroxycarboxylic acid and a linear or branched C6-C22 aliphatic alcohol, especially dioctyl malate, Chirality, linear and / or branched fatty acids and polyhydric alcohols (e.g., propylene glycol , dimer diols or trimer triols) and / or esters of Guerbet alcohols, triglycerides based on C6-C10 fatty acids, liquid mono- / di- / triglyceride mixtures based on C6-C18 fatty acids, C6-C22 aliphatic alcohols and / or esters of Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid, C2-C12 dicarboxylic acids with linear or branched alcohols having from 1 to 22 carbon atoms, or esters of polyols having from 2 to 10 carbon atoms and from 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear and branched C C-C2 2 aliphatic alcohol carbonates, e.g., dicaprylyl carbonate (Cetiol® CC), Guerbet carbonates based on aliphatic alcohols having from 6 to 18, preferably from 8 to 10 carbon atoms, esters of benzoic acid with linear and / or branched C -C 2 alcohols (e.g., Finsolv® TN), linear or branched, symmetric or asymmetric dialkyl ethers having from 6 to 22 carbon atoms per alkyl group , e.g., dicaprylyl ether (Cetiol® OE), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (such as cyclomethicone, silicone methylene grade, etc.), and / or aliphatic or naphthenic hydrocarbons, e.g., squalane, squalene or dialkylcyclohexane are also suitable. 6 ~C 22 - esters of alcohols (e.g., Finsolv® TN), linear or branched, symmetric or asymmetric dialkyl ethers having from 6 to 22 carbon atoms per alkyl group , e.g., dicaprylyl ether (Cetiol® OE), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (such as cyclomethicone, silicone methylene grade, etc.), and / or aliphatic or naphthenic hydrocarbons, e.g., squalane, squalene or dialkylcyclohexane are also suitable. esters with polyols, silicone oils (such as cyclomethicone, silicone methylene grade, etc.), and / or aliphatic or naphthenic hydrocarbons, e.g., squalane, squalene or dialkylcyclohexane are also suitable. esters with polyols, silicone oils (such as cyclomethicone, silicone methylene grade, etc.), and / or aliphatic or naphthenic hydrocarbons, e.g., squalane, squalene or dialkylcyclohexane are also suitable. esters with polyols, silicone oils (such as cyclomethicone, silicone methylene grade, etc.), and / or aliphatic or naphthenic hydrocarbons, e.g., squalane, squalene or dialkylcyclohexane are also suitable.
[0264] In the context of the present invention, cosmetics according to the first or second aspect of the present invention, or The pharmaceutical composition, or home care product, can also be combined with other conventional active substances, adjuvants or additives and in some cases this is advantageous.
[0265] Optionally, other conventional active substances, adjuvants or additives for cosmetic or pharmaceutical compositions, or home care products, can be added as constituent (c) i.e. to obtain an immediately usable composition or formulation.
[0266] The cosmetic, or pharmaceutical composition, or home care product according to the invention can advantageously be combined with other active agents and / or adjuvants and / or additives or auxiliaries, for example such compositions, such as abrasives, anti-acne agents, agents against skin aging, anti-folliculitis agents, anti-dandruff agents, anti-inflammatory agents, irritation preventers, irritation inhibitors, antioxidants, astringents, odor absorbers, antiperspirants, disinfectants, antistatic agents, binders, buffers, carrier materials, chelating agents, cell stimulants, cleansing agents, depilatory agents, surface active substances, deodorant agents, antiperspirant agents, emollients, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibers, film formers fixatives, foam formers, foam stabilizers, foam preventers, foam boosters, gelling agents, gel formers, hair care agents, hair setting agents, hair straightening agents, moisture donors, moisturizing substances, water-retaining substances, bleaching agents, enhancers, stain removers, optical brighteners, impregnating agents, dirt-repellent agents, pigments, friction reducers, lubricants, moisturizing creams, ointments, opacifiers, plasticizers, coating agents, polishing agents, preservatives, brighteners, synthetic polymers, powders, proteins, refatting agents, abrasives, silicones, skin soothers, skin cleansing agents, skin care agents, skin healing agents, etc. nt agents), pigments, friction reducers, lubricants, moisturizing creams, ointments, opacifiers, plasticizers, coating agents, polishing agents, preservatives, brighteners, synthetic polymers, powders, proteins, refatting agents, abrasives, silicones, skin soothers, skin cleansing agents, skin care agents, skin healing agents, etc. Agents, whitening agents, skin protectants, skin softeners, hair growth promoters, cooling agents, skin cooling agents, warming agents, skin warming agents, stabilizers, surfactants, UV absorbers, UV filters, first sunscreen factor, second sunscreen factor, detergents, fabric conditioning agents, suspending agents, skin tanning agents, skin or hair pigment regulating active substances, matrix - metalloprotease inhibitors, skin moisturizers, glycosaminoglycan stimulants, TRPV1 antagonists, peeling agents, anti - cellulite agents or fat enhancing agents, hair growth active substances or inhibitors, thickeners, rheology additives, vitamins, oils, waxes, nacreous waxes, fats, phospholipids, saturated fatty acids, monounsaturated or polyunsaturated fatty acids, α - hydroxy acids, polyhydroxy fatty acids, liquefiers, dyes, color protectants, pigments, rust preventives, fragrances or essential oils, perfumes, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, and Mixtures of two or more of the aforementioned substances, as further described below, are customarily used.
[0267] Among the above - mentioned cosmetic or pharmaceutical active agents and / or adjuvants and / or additives or auxiliaries, antioxidants, chelating agents, emulsifiers, surfactants preservatives, synthetic polymers, skin cooling agents, rheology additives, oils, fragrances or essential oils and polyols are particularly preferred for the preparation of cosmetic and pharmaceutical compositions.
[0268] Skin lesions or diseases are often associated with dry skin, wounded skin, skin lesions or even inflammation. Therefore, the cosmetic or pharmaceutical composition according to the present invention is advantageously preferably an anti - inflammatory drug, an antibacterial or antifungal substance, a substance having a redness - reducing or itching - reducing effect, an analgesic substance, a Isolizer and / or coolant, osmolyte, keratolytic substance, growth substance, anti- inflammatory agent, antibacterial or antifungal substance, substance having a redness-reducing or itching-reducing effect, analgesic substance, anti-dandruff substance or other active compound, for example solvent, fragrance, antioxidant, preservative agent, (metal) chelating agent, permeation enhancer or a mixture of two or more of the aforementioned agents further described below. It contains.
[0269] Cosmetic or pharmaceutical active agents and / or adjuvants and / or additives provide, in some instances, one or more benefits or act via more than one mode of action.
[0270] Anti-aging active substances: The cosmetic or pharmaceutical composition according to the invention preferably contains one or more anti-aging active substances. For the purposes of the present invention, anti-aging or biogenic agents are, for example, antioxidants, matrix metalloproteinase inhibitors (MMPIs), skin moisturizers, glycosaminoglycan stimulating substances, anti-inflammatory agents, TRPV1 antagonists and plant extracts.
[0271] Antioxidants: Preferred cosmetic or pharmaceutical compositions according to the invention contain one or more antioxidants. Suitable antioxidants are amino acids (preferably glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (preferably urocanic acid) and their derivatives, peptides, preferably D,L-carnosine, D-carnosine, L-carnosine and their derivatives (preferably anserine), carnitine, creatine, matrix Inpeptide (preferably lysyl-threonyl-threonyl-lysyl-serine) and pa Lumitoylated pentapeptide, carotenoid, carotene (preferably alpha-carotene , beta-carotene, lycopene) and its derivatives, lipoic acid and its derivatives (preferably Dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (preferably Thioredoxin, glutathione, cysteine, cystine, cystamine and glyc Syl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, pal Mitoyl, oleyl, gamma-linoleyl, cholesteryl, glyceryl and its oligo Glyceryl ester) and its salts, dilauryl thiodipropionate, distearyl thio Dipropionate, thiodipropionic acid and its derivatives (preferably esters, ethers , peptides, lipids, nucleotides, nucleosides and salts), and very small Sulphoximine compounds at tolerances (e.g. pmol to μmol / kg) (preferably but Onine sulphoximine, homocysteine sulphoximine, butionine sulphone, penta- , hexa-, hepta-thionine sulphoximine), and also (metal) chelating agents (preferably Alpha-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin, alpha- Hydroxy acids (preferably citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts , tannins, bilirubin, biliverdin, EDTA, EGTA and their derivatives), unsat urated fatty acids and their derivatives (preferably gamma-linolenic acid, linoleic acid, oleic acid) , folic acid and its derivatives, ubiquinone and its derivatives, ubiquinol and its derivatives , vitamin C and derivatives (preferably ascorbyl palmitate, ascorbyl phosphate Mg, ascorbyl acetate, ascorbyl glucoside), tocopherol and derivatives (preferably vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoic resin, rutinic acid and its derivatives, flavonoids and their glycosylated precursors, especially quercetin and its derivatives, preferably alpha-glucosylrutin, rosmarinic acid, carnosol, ca rnosic acid, resveratrol, caffeic acid and its derivatives, sinapic acid and its derivatives ferulic acid and its derivatives, curcuminoids, chlorogenic acid and its derivatives, retinoids, preferably retinyl palmitate, retinol or tretinoin, ursolic acid, levulinic acid, butylhydroxytoluene, butylhydroxyanisole, nordi hydroguaiaretic acid, nordihydro guaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (preferably ZnO, ZnSO 4 ), selenium and its derivatives (preferably selenomethionine), superoxide dismutase, st ilbene and its derivatives (preferably stilbene oxide, trans-stilbene oxide ), and derivatives of these cited active ingredients ( salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids), or plants having an antioxidant effect, preferably green tea, rooibos, honeybush, grape, ro semary, sage, melissa, thyme, lavender, olive, triticale, cocoa, Ginkgo, carrot, licorice, honeysuckle, sophora, pueraria, m ulberries, citrus fruits, Phyllanthus emblica or St. John's wort, b rape seeds, wheat germ, extracts or fractions of Phyllanthus emblica , coenzymes, preferably coenzyme Q10, plastoquinone and menaquinone are included . Preferred antioxidants are vitamin A and derivatives, vitamin C and derivatives, tocopher ols and derivatives, preferably tocopheryl acetate, and ubiquinone selected from the group consisting of . When vitamin E and / or its derivatives are used as antioxidant(s), a concentration in the range of about 0.001 to about 10% by weight is advantageously selected relative to the total weight of the composition. When vitamin A or vitamin A derivative, or carotene or its derivative is used as antioxidant(s), a concentration in the range of about 0.001 to about 10% by weight is advantageously selected relative to the total weight of the composition.
[0272] Matrix - metalloproteinase inhibitor (MMPI): Preferred cosmetic or pharmaceutical compositions according to the present invention comprise one or more matrix - metalloproteinase inhibitors, in particular those that inhibit matrix - metalloproteinases that enzymatically cleave collagen and include ursolic acid, retinyl palmitate, propyl gallate, precocene, 6 - hydroxy -7 - methoxy - 2,2 - dimethyl - 1(2H)-benzopyran, 3,4 - dihydro -6 - hydroxy - 7 - methoxy - 2,2 - dimethyl - 1(2H)-benzopyran, benzamidine hydrochloride, cysteine protease inhibitor N - ethylmaleimide (N - e thylmalemide) and epsilon-amino-n of serine protease inhibitors -caproic acid: phenylmethylsulfonyl fluoride, collhibin (Pentaphar m; INCI: hydrolyzed wheat protein), oenotherol (Soliance; INCI: PG, water, Oenothera biennis root extract), ellagic acid and ellagitannins, (for example from pomegranate), phospholamide hinokitiol, EDTA, galardin, Equi Stat (Collaborative Group; apple fruit extract, soybean seed extract, ursolic acid, soybean isoflavones and soybean protein), sage extract, MDI (Atrium; INCI: mucopolysaccharide), fermiskin (Silab / Maw i; INCI: water and Lentinus edodes extract), actimp 1.9.3 (Expanscience / Rahn; IN CI: hydrolyzed lupinus protein), lipobelle soyaglycone (Mibelle; INCI: ethanol, polysorbate 80, lecithin and soybean isoflavones), extracts from green tea and black tea and further plant extracts, proteins or glycoproteins from soybean, rice, pea or hydrolyzed proteins from lupinus, plant extracts that inhibit MMP, preferably extracts from the mushroom shiitake, extracts from the leaves of the Rosaceae, Rosoideae subfamily, in particular, for example SymM atrix (Symrise, INCI: maltodextrin, European wild strawberry leaf (Symrise; INCI: maltodextrin, European wild strawberry leaf extract), extracts from the Rosaceae, Rosoideae subfamily, in particular, for example SymM atrix (Symrise; INCI: maltodextrin, European wild strawberry leaf extract), extracts from the Rosaceae, Rosoideae subfamily, in particular, for example SymM atrix (Symrise; INCI: maltodextrin, European wild strawberry leaf extract), extracts from the Rosaceae, Rosoideae subfamily, in particular, for example SymM (Symrise; INCI: maltodextrin, European wild strawberry leaf extract), extracts from the Rosaceae, Rosoideae subfamily, in particular, for example SymM Selected from the group consisting of extracts of blackberry leaves such as Extract (Rubus Fruticosus (Blackberry) Leaf Ext ract)). Preferred active substances are retinyl palmitate, ursolic acid, extracts from the leaves of the Rosaceae family, Rosoideae subfamily, genistein and daidzein.
[0273] Skin moisturizer: Preferred cosmetic or pharmaceutical compositions according to the present invention contain one or more skin moisturizers. Preferred skin moisturizers are alkanediols or alkanetriols containing 3 to 12 carbon atoms, preferably C ~C 3 ~C 10 -alkanediol and C 3 ~C 10 -alkanetriol. More preferably, the skin moisturizer is glycerol, 1,2-propylene glycol, 1,2-butylene glycol, 1,3- butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2- octanediol and 1,2-decanediol.
[0274] Glycosaminoglycan stimulant: Preferred cosmetic or pharmaceutical compositions according to the present invention contain one or more substances that stimulate the synthesis of glycosaminoglycans, which are hyaluronic acid and derivatives or salts, Subliskin (Sederma, IN CI: alfalfa rhizobium culture broth (Sinorhizobium Meliloti Ferment Filtrate), cetyl hydroxyethyl cellulose, lecithin) ), Hyalufix (BASF, INCI: water, BG, arrowroot ), Galangal leaf extract, xan than gum, tri(caprylic / capric) glyceryl, Stimu lhyal)(Soliance, INCI: Calcium ketogluconate), Syn- Glycan)(DSM, INCI: Tetradecyl aminobutyroyl alylaminobutyric urea trifluoroacetate), glycerin, magnesium chloride), Kalpariane)(Biotech M arine), DC Upregulexx)(Disti nctive Cosmetic Ingredients, INCI: water, BG, phos pholipids, hydrolyzed sericin), glucosamine, N-acetylglucosamine, retinoids, pref erably retinol and vitamin A, Arctium lappa fruit extract, Eri obotrya japonica extract, genkwain, N-methyl-L-serine, (-)-alpha-bisabolol or synthetic alpha-bisabolol, e.g. Symris e's dragosantol and dragosantol 100, hordeum vulgare glucan, Echinacea purpurea extract and soy protein hydrolysate. Preferred active substances are hyaluronic acid and its deriv atives or salts, retinol and derivatives, (-)-alpha-bisabolol or synthetic al pha-bisabolol, e.g. Symrise's dragosantol (Dragosa ntol) and dragosantol 100, hordeum vulgare glucan, Echinacea purpurea extract, Sinorhizobium Meliloti fermentation filtrate, ke calcium gluconate, Alpinia galanga leaf extract and trifluoro selected from the group consisting of tetradecyl aminobutyroyl valyl aminobutyric acid urea acetate.
[0275] TRPV1 antagonist: A preferred cosmetic or pharmaceutical composition according to the present invention contains one or more TRPV1 antagonists. As TRPV1 antagonists, suitable compounds that suppress skin nerve hypersensitivity based on their action include, for example, trans-4-te rt-butylcyclohexanol, or indirect regulators of TRPV1 by activation of μ-receptors, such as acetyltet rapeptide-15, are preferred.
[0276] Plant extract: A preferred cosmetic or pharmaceutical composition according to the present invention contains one or more plants extracts. Plant extracts, particularly highly active plant extract fractions, and highly pure active substances isolated from plant extracts can also be used in the cosmetic or pharmaceutical compositions according to the present invention . Extracts, fractions and active substances from chamomile, aloe vera, Commiphora species, Rubia species, willow, aca bana, ginger, marigold, arnica, Glycyrrhiza species, Echinace a species, Rubus species, as well as pure substances, such as parti cular bisabolol, apigenin, apigenin-7-glucoside, gingerol, for example [6]-gingerol, paradol, for example [6]-paradol, boswellic acid, phyto sterols, glycyrrhizin, glabridin or licocarpin A are particularly preferred.
[0277] Anti-inflammatory agent: The cosmetic or pharmaceutical composition according to the present invention preferably contains an anti-inflammatory agent and / or a component that relieves redness and / or itching, and in particular, steroid substances of the corticosteroid type are selected from the group consisting of hydrocortisone, dexamethasone, dexamethasone phosphate , methylprednisolone or cortisone, and these are preferably used as an anti-inflammatory active ingredient or an active ingredient that reduces redness and itching, and the enumeration of these can be expanded by adding other steroid anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs can also be used. More particularly: (i) Steroid anti-inflammatory substances of the corticosteroid type, especially hydrocortisone, hydro cortisone derivatives, such as hydrocortisone 17-butyrate, dexamethasone, li dexamethasone phosphate, methylprednisolone or cortisone, (ii) Non-steroidal anti-inflammatory substances, especially oxicams, such as piroxicam or tenoxicam , salicylates, such as aspirin, disalcid, sorpirin or fendosal ur, acetic acid derivatives, such as diclofenac, fenclofenac, indomethacin, sulindac , tolmetin or clindanac, fenamates, such as mefenamic, meclofenamic , flufenamic or niflumic, propionic acid derivatives, such as ibuprofen , naproxen or benoxaprofen, pyrazoles, such as phenylbutazone , oxyphenylbutazone, febrazone or azapropazone, (iii) Natural or naturally occurring anti-inflammatory substances or substances that relieve redness and / or itching , especially chamomile, aloe vera, Commiphora species, Rubia species, willow, nettle, rye, saffron, arnica, St. John's wort, honey - Suckle, Rosemary, Passiflora incarnata, Manske, Shi Extracts or fractions from ginger or Echinacea, or their single active compounds, (iv) Histamine receptor antagonists, serine protease inhibitors (e.g., from soybean extracts), TRPV1 antagonists (e.g., 4-t-butylcyclohexanol), N K1 antagonists (e.g., aprepitant, hydroxyphenylpropanamide benzoic acid) , cannabinoid receptor agonists (e.g., palmitoylethanolamine) and TR PV3 antagonists.
[0278] Examples that may be cited herein are oxicams, such as piroxicam or tenoxicam; salicylates, such as aspirin, disalcid, solpyrin or fendosal; acetic acid derivatives, such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac; fenamates, such as mefenamic, meclofenamic c, flufenamic or niflumic; propionic acid derivatives, such as ibuprofen , naproxen, benoxaprofen or pyrazoles, such as phenylbutazone, o xyphenylbutazone, febrazone or azapropazone. Anthranilic acid derivatives
[0279] Substances or mixtures of substances that relieve redness and / or itching, especially chamomile, a loe vera, Commiphora species, Rubia species, willow, akabana, rye, ki nsonca, arnica, St. John's wort, honeysuckle, rosemary, Pas Extraction from Siflora incarnata, Mansaku, Ginger or Echinacea of a substance or fraction; preferably chamomile, aloe vera, rye, celosia, alni ca, honeysuckle, rosemary, mansaku, ginger or echinacea, and / or pure substances, preferably alpha-bisabolol, apigenin, apigenin-7-glu coside, gingerol, shogaol, shoga-diol, dehydrogingerdione , paradol, natural, or naturally occurring avenanthramide, preferably tranilast , avenanthramide A, avenanthramide B, avenanthramide C, non-natural or not naturally occurring avenanthramide, preferably dihydroavenanthramide D, dihydroaven anthramide E, avenanthramide D, avenanthramide E, avenanthramide F, boswell ic acid, plant sterols, glycyrrhizin, glabridin and licocchalcone A from an extract or fraction selected from the group consisting of; preferably alpha-bisabolol, natural avenanthramide, non-natural avenanthramide, preferably dihydroavenanthramide D( described in WO2004047833A1), boswellic acid, plant sterols, glycyrrhizin, and licocchalcone A, and / or allantoin, panthenol, lanolin, (pseudo) ceramide [preferably ceramide 2, hydroxypropyl bispalmit mid MEA, cetyl oxypropyl glyceryl methoxypropyl myristamide, N-(1 -hexadecanoyl) -4-hydroxy-L-proline (1-hexadecyl) ester, hydroxyethyl palmityloxy hydroxypropyl palmitamide], glycosphing olipids, plant sterols, chitosan, mannose, lactose and beta-glucan, especially Natural, or naturally occurring anti-inflammatory mixtures selected from the group consisting of 1,3->1,4-β-glucan from rye are also useful.
[0280] When bisabolol is used in connection with the present invention, it can be of natural or synthetic origin, preferably "alpha-bisabolol". Preferably, the bisabolol used is synthetically prepared or natural (-)-alpha-bisabolol and / or synthetic mixed-isomer alpha-bisabolol. When natural (-)-alpha-bisabolol is used, it can also be used as a constituent element of essential oils, or plant extracts or fractions thereof, for example, as a constituent element of the oil or extract (fraction) of chamomile or Vanillosmopsis (especially Vanill osmopsis erythropappa or Vanillosmopsis a rborea). Synthetic alpha-bisabolol is available, for example, under the name "Dragosantol" from Symrise.
[0281] In cases where ginger extract is used in connection with the present invention, preferably an extract of fresh or dried ginger root is used, which is prepared by extraction with methanol, ethanol, isopropanol, acetone, ethyl acetate, carbon dioxide (CO 2), hexane, methylene chloride, chloroform, 2 or other solvents or solvent mixtures of equivalent polarity. The extract is characterized by the presence of components that reduce active skin irritation, such as gingerol, shogaol, gingerdiol, dehydrogingerdione and / or paradol.
[0282] Physiological coolants: The cosmetic or pharmaceutical composition according to the invention can, particularly advantageously, be combined with one or more physiological coolants (plural possible). The use of the coolant can relieve itching. The individual coolants preferred for use within the framework of the present invention are listed below. Those skilled in the art may add many other coolants to this list; the listed coolants can be used in combination with each other: these are preferably selected from the following list herein : menthol and menthol derivatives (e.g., L-menthol, D-menthol, racemic menthol, isomenthol, neoisomenthol, neomenthol) methyl ether (e.g., (I-menthoxy)-1,2-propanediol, (l-menthoxy )-2-methyl-1,2-propanediol, l-menthyl-methyl ether), menthyl glyceryl acetal, menthone glyceryl ketal or a mixture of both, menthyl esters (e.g., menthyl formate, menthyl acetate, menthyl isobutyrate, menthyl hydroxyisobutyrate, menthyl lactate, L-menthyl-L-lactate , L-menthyl-D-lactate, menthyl-(2-methoxy)acetate, menthyl-(2- methoxyethoxy)acetate, menthyl pyrogallate), menthyl carbonate (e.g., menthyl propylene glycol carbonate, menthyl ethylene glycol carbonate , menthyl glycerol carbonate or a mixture thereof), the semi-ester of menthol and dicarboxylic acid or its derivatives (e.g., mono-menthyl succinate, mono- menthyl glutarate, mono-menthyl malonate, O-menthyl succinate-N , N-(dimethyl) amide, O-menthyl succinate amide), menthane carboxylic acid amide (in this case, preferably menthane carboxylic acid-N-ethylamide [WS3 or N α -(menthane carbonyl) glycine ethyl ester [WS5], menthane car boxylic acid-N-(4-cyanophenyl) amide or menthane carboxylic acid-N-(4- cyanomethylphenyl) amide, menthane carboxylic acid-N-(alkoxyalkyl) amide ), menthone and menthone derivatives (e.g., L-menthone glycerol ketal), 2, 3-dimethyl-2-(2-propyl)-butyric acid derivatives (e.g., 2,3-dimethyl-2-(2 -propyl)-butyric acid-N-methylamide [WS23]), isopulegol or its es ter (I-(-)-isopulegol, I-(-)-isopulegol acetate), menth ane derivatives (e.g., p-menthane-3,8-diol), cubebol or a synthetic or natural mixture containing cubebol, pyrro lidone derivatives of cycloalkyldione derivatives (e.g., 3-methyl-2(1-pyrrolidinyl)-2-cyclopenten-1- one) or tetrahydropyrimidin-2-one (e.g., iciline or related compounds described in WO2004 / 026840 ), further carboxamides (e.g., N-(2-(pyridin-2-yl) ethyl)-3-p-menthane carboxamide or related compounds), (1R,2S,5R)-N-(4-methoxyphenyl)-5-meth yl-2-(1-isopropyl) cyclohexane-carboxamide [WS12], oxa mate and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl 2-(Ethylamino)-2-oxo-acetate (X Cool). Due to certain synergistic effects preferred coolants are l-menthol, d-menthol, racemic menthol, menthone glycerol acetal (trade name: Frescolat® MGA), menthyl lactate (preferably l-menthyl lactate, especially l-menthyl l-lactate (trade name: Frescolat® ML)), substituted menthyl-3-carboxamide ( for example menthyl N-ethylamide of 3-carboxylic acid), 2-isopropyl-N-2,3- trimethylbutanamide, substituted cyclohexanecarboxamide, 3-menthoxypropane -1,2-diol, 2-hydroxyethyl menthyl carbonate, 2-hydroxypro pyl menthyl carbonate and isopulegol. Particularly preferred coolants are l- menthol, racemic menthol, menthone glycerol acetal (trade name: Fresco lat® MGA), menthyl lactate (preferably l-menthyl lactate , especially l-menthyl l-lactate (trade name: Frescolat® ML)) , 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthyl carbonate and 2-hydroxypropyl menthyl carbonate. Extremely particularly preferred coolants are l-menthol, menthone glycerol acetal (trade name: Frescol at® MGA) and menthyl lactate (preferably l-menthyl lactate , especially l-menthyl l-lactate (trade name: Frescolat® ML) .
[0283] Moisturizing and / or water-retaining substances: Itching occurs with a specific intensity when the skin is dry It occurs. The use of skin moisturizing and / or water-retaining substances can significantly relieve itching. The cosmetic or pharmaceutical composition according to the present invention may thus advantageously also contain one or more of the following moisturizing and / or water-retaining substances: sodium lactate, urea, urea derivatives, alcohols , glycerol, diols such as propylene glycol, hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipate, petrolatum, urocanic acid , lecithin, panthenol, phytantriol, lycopene, (pseudo)ceramide, sphingoglycolipid, cholesterol, plant sterols, chitosan, chondroitin sulfate, lanolin , lanolin esters, amino acids, alpha-hydroxy acids (e.g., citric acid, lactic acid, linoleic acid) and their derivatives, mono-, di- and oligosaccharides such as glucose, gala ctose, fructose, mannose, fructose and lactose, polysaccharides such as R -glucan, especially 1,3-1,4-β-glucan from Triticum aestivum, alpha-hydroxy fatty acids, triterpenic acids such as betulinic acid or ursolic acid, and algal extracts .
[0284] Analgesic substances: The cosmetic or pharmaceutical composition according to the present invention may advantageously also contain one or more analgesic substances, and any analgesic substance suitable or conventional for cosmetic or pharmaceutical use, such as al pha-bisabolol, azulene, guaiazulene, 18-beta-glycyrrhetinic acid, a lantoin, aloe vera juice or gel, Hamamelis virginian a (witch hazel), Echinacea species, Centella asiatica, chamomile , Arnica montana, Glycyrrhiza species, algae, seaweeds and Extracts of Calendula officinalis, as well as vegetable oils such as sweet almond oil, baobab oil, olive oil, as well as panthenol, laureth-9, trideceth-9, and 4-t-butylcyclohexanol can be used.
[0285] Antibacterial or antifungal substances: Antibacterial or antifungal substances can also, particularly advantageously, be used in the cosmetic or pharmaceutical compositions according to the invention, and any conventional antibacterial or antifungal substance suitable for cosmetic or pharmaceutical use, particularly for dermatological applications, can be used. In addition to the large group of conventional antibiotics, other products that are advantageous herein are those related to cosmetics, such as particularly triclosan, clotrimazole, octoxyglycerin, Octopirox® (1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridin-2- amine ethanol salt), chitosan, farnesol, glycerol monolaurate or combinations of the said substances, which are used, inter alia, against underarm odor, foot odor or dandruff.
[0286] Desquamating agents: The cosmetic or pharmaceutical compositions according to the invention preferably contain one or more desquamating agents. The expression "desquamating agent" means: - Any compound capable of acting directly on desquamation by promoting exfoliation, such as β-hydroxy acids, particularly salicylic acid and its derivatives (including 5-n-octanoyl salicylic acid); α-hydroxy acids, such as glycolic acid, citric acid, lactic acid, tartaric acid malic acid or mandelic acid; urea; gentisic acid; oligofucose; cinnamic acid; extract of Sophora japonica; resveratrol and some of jasmonic acid Derivative; - Or any compound capable of acting on enzymes involved in the desquamation or degradation of corneodesmosomes, glycosidases, stratum corneum chymotryptic enzyme (SC CE) or other proteases (trypsin, chymotrypsin-like). Chelating agents for inorganic salts: EDTA; N-acyl-N,N’,N’-ethylenediaminetriacetic acid; aminosulfonic acid compounds, especially (N-2-hydroxyethylpiperazine-N-2 -ethane)sulfonic acid (HEPES); derivatives of 2-oxothiazolidine-4-carboxylic acid (pro cysteine); derivatives of glycine-type alpha-amino acids (as described in EP-0852 949 and sodium methylglycinediacetate marketed by BASF under the trade name TRILON M); honey; sugar derivatives such as O- octanoyl-6-D-maltose and N-acetylglucosamine; extracts of quince, such as those marketed by SILAB under the name Recoverine (registered trademark), prickly pear extract, such as those marketed by SILAB under the name Exfolactive (reg istered trademark), or Phytosphingosine SLC (registered trademark) marketed by Degussa (phytosphingosine graphed with salicylic acid) may be mentioned. Preferred desquamating agents for the present invention are, in particular, sulfonic acids, calcium chelating agents, alpha-hydroxy acids such as glycolic acid, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; ascorbic acid and its derivatives such as ascorbyl glucoside and ascorbyl phosphate ;
[0287] Magnesium; Nicotinamide; Urea; (N-2-hydroxyethylpiperazine-N-2 -ethane)sulfonic acid (HEPES), β-hydroxy acids such as salicylic acid and its derivatives, retinoids such as retinol and its esters, retinol, retinoic acid and its derivatives, especially the CLEAR or PRICKLY PEAR extract marketed by SILAB; selected from the group consisting of reducing compounds such as cysteine or cysteine precursors can be obtained. Desquamating agents that can be used are nicotinic acid also known as vitamin B3 or vitamin PP and its esters, and nicotinamide, as well as ascorbic acid and its precursors are also available.
[0288] Antidandruff agents: Furthermore, the cosmetic or pharmaceutical composition according to the invention comprises one or more antidandruff agents in combination with triclosan, climbazole, octoxyglycerin, Octopirox® (1-hydroxy- 4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone 2-amino ethanol salt), chitosan, farnesol, glycerin monolaurate, propandiol monocaprylate or a combination of said substances, which are advantageously used especially against dandruff.
[0289] (2,4,4-trimethylpentyl)-2-(1H)-pyridinone monoethanolamine salt), Baypival® (climbazole), Ketoconazol® ( registered trademark)(4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1 (H-imidazol-1-ylmethyl)-1,3-dioxolan-c-4-ylmethoxyf enyl}-piperazine, ketoconazole, erviol, selenium disulfide, colloidal sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinole polyeth xylate, sulfur tar fraction, salicylic acid (or in combination with hexachlorophene) , undecylenic acid, monoethanolamide sulfosuccinate Na salt, Lamepon( registered trademark) UD (protein / undecylenic acid condensate), zinc pyrithione, aluminum pyrithione and magnesium pyrithione / dipyrithione magnesium sulfate are present.
[0290] (Metal) chelating agents: Combinations with one or more (metal) chelating agents can also be advantageously used in the cosmetic or pharmaceutical compositions according to the present invention, and any metal chelating agent suitable or customary for cosmetic or pharmaceutical use can be used. Preferred (metal) chelating agents include α-hydroxy fatty acids, phytic acid, lactoferrin, α-hydroxy acids, such as especially gluconic acid, glyceric acid, glycolic acid, isocitric acid, citric acid, lactic acid, malic acid, mandelic acid , tartaric acid, as well as humic acid, bile acids, bile extracts, bilirubin, biliverdin or E DTA, EGTA and their derivatives. The use of one or more chelating agents (plural possible) improves the stability of the compositions according to the present invention. Emulsifiers: Furthermore, the cosmetic or pharmaceutical compositions according to the present invention advantageously include, for example: - Linear C
[0291] aliphatic alcohols with 2 to 30 mol of ethylene oxide and / or 0 to 5 mol of propylene oxide of 8~22 12~22Addition products to fatty acids and to alkylphenols containing from 8 to 15 carbon atoms in the alkyl group; - Addition products of from 1 to 30 mol of ethylene oxide to glycerol, C 12 / 18 fat fatty acid monoesters and diesters; - Glycerol mono- and di-esters of saturated and unsaturated fatty acids containing from 6 to 22 carbon atoms, and sorbitan mono- and diesters, and their ethylene oxide addition products; - Addition products of from 15 to 60 mol of ethylene oxide to castor oil and / or hydrogenated castor oil; - Polyol esters, and especially polyglycerol esters, such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or poly glycerol dimereate isostearate. Mixtures of compounds from several of these classifications are also suitable; - Addition products of from 2 to 15 mol of ethylene oxide to castor oil and / or hydrogenated castor oil; - Linear, branched, unsaturated or saturated C 6 / 22 fatty acids, ricinoleic acid and 12-hydroxy stearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (such as sorbitol), alkyl glucosides (such as methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (such as cellulose) based partial esters; - Mono-, di- and trialkyl phosphates and mono-, di- and / or tri- -PEG-alkyl phosphates and their salts; - Wool wax alcohol; - Polysiloxane / polyalkyl polyether copolymers and corresponding derivatives; - Mixed esters of pentaerythritol, fatty acids, citric acid and aliphatic alcohols, and / or C 6~22 mixed esters of fatty acids, methyl glucose and polyols, preferably glu cerol or polyglycerol, - Polyalkylene glycols, and - One or more emulsifiers including glycerol carbonate may also be contained.
[0292] Aliphatic alcohols, fatty acids, a lkylphenols, glycerol mono- and diesters of fatty acids and sorbitan mo no- and diesters, or addition products to castor oil, are known commercially available products and these are homologous mixtures whose average degree of alkoxylation corresponds to the ratio between the amount of ethylene oxide and / or propylene oxide and the substrate on which the addition reaction is carried out. C fatty acid monoesters and 12 / 18 diesters of the addition product of ethylene oxide to glycerol are known as lipid layer enhancers for cosmetic formulations. Preferred emulsifiers are described in more detail as follows: Partial glycerides: Typical examples of suitable partial glycerides are monoglyceride hydroxystearate, diglyceride hydroxystearate, monoglyceride isostearate,
[0293] diglyceride isostearate, monoglyceride oleate, diglyceride oleate, monoglyceride ricinoleate, diglyceride ricinoleate, monoglyceride linoleate, diglyceride linoleate, monoglyceride linolenate, diglyceride linolenate, erucic acid monoglyceride, diglyceride erucic acid, monoglyceride palmitate, diglyceride palmitate, etc. acid monoglyceride, diglyceride erucic acid, monoglyceride palmitate, diglyceride palmitate, etc. Monoglyceride acids, diglyceride erucates, monoglyceride tartrates, diglyceride tartrates , monoglyceride citrates, diglyceride citrates, monoglyceride malates, malic acid Diglycerides, and their techniques that may still contain small amounts of triglycerides from the production process is a mixture. The addition products of 1 to 30, preferably 5 to 10 mol of ethylene oxide to the partial glycerides mentioned are also suitable.
[0294] Sorbitan esters: Suitable sorbitan esters are sorbitan monoisostearate , sorbitan sesquisoisostearate, sorbitan diisostearate, triisostear Phosphate sorbitan, sorbitan monooleate, sorbitan sesquioleate, diole Nate sorbitan, sorbitan trioleate, sorbitan monoerucate, sesquierucic acid Sorbitan, sorbitan dierucate, sorbitan trierucate, sorbitan monolicanolate Tan, sorbitan sesquilicanolate, sorbitan dilicanolate, sorbitan trilicanolate Rubitan, sorbitan monohydroxystearate, sorbitan sesquihydroxystearate Rubitan, sorbitan dihydroxystearate, sorbitan trihydroxystearate , sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate Rubitan, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate , sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, Sorbitan dimaleate, sorbitan trimaleate and their technical mixtures . The addition products of 1 to 30 and preferably 5 to 10 mol of ethylene oxide to the sorbitan esters mentioned are also suitable.
[0295] Polyglycerol esters: Typical examples of suitable polyglycerol esters are polygly ceryl-2-dipolyhydroxystearate (Dehymuls® PGPH) , polyglycerin-3-diisostearate (Lameform® TGI), polyglyceryl-4 isostearate (Isolan® GI 34), polyglyceryl-3 oleate, diisostearyl polyglyceryl-3 diisostearate (Isolan® PDI), polyglyceryl-3 methylglucose distearate (Tego Care® 450), polyglyceryl-3 beeswax (Cera Bellina®), polyglyceryl-4 caprate (polyglycerol caprate T2010 / 90), polyglyceryl-3 cetyl ether (Chimexane® NL), polyglyceryl-3 distearate (Cremophor® GS 32) and polyglyceryl polyricinoleate (Admul® WOL 1403), polyglyceryl dimelate isostearate, and mixtures thereof. Examples of other suitable polyol esters are the mono-, di- and triesters of lauric acid, coco fatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid, etc. reacted with trimethylolpropane or pentaerythritol, optionally with 1 to 30 mol of ethylene oxide.
[0296] Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12 to C22 fatty acids such as palmitic acid, stearic acid or behenic acid, and C12 to , for example, azelaic acid or sebacic acid.
[0297] Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric or zwitterionic surfactants. Zwitterionic surfactants are surface-active compounds containing at least one quaternary ammonium group, at least one carboxylate, and one sulfonate group in the molecule. Particularly preferred zwitterionic surfactants are so-called betaines, for example, N-alkyl-N,N-dimethylammonium glycinate containing 8 to 18 carbon atoms in the alkyl or acyl group, such as cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinate, such as cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3-carboxymethyl-3-hydroxyethylimidazoline, and cocoacylaminoethylhydroxyethylcarboxymethylglycinate. The well-known fatty acid amide derivatives with the CTFA name of cocamidopropyl betaine are particularly preferred. Amphoteric surfactants are also suitable emulsifiers. Amphoteric surfactants are surface-active compounds containing at least one free amino group and at least one -COOH- or -SOH- group in addition to the C alkyl or acyl group, and capable of forming an inner salt in the molecule. Examples of suitable amphoteric surfactants are approximately N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N-alkyl containing 8 to 18 carbon atoms in the alkyl group. ammonium glycinate, for example, cocoalkyl dimethyl ammonium glycinate, N-acyl aminopropyl-N,N-dimethyl ammonium glycinate, for example, cocoacylamino propyl dimethyl ammonium glycinate, and 2-alkyl-3-carboxymethyl methyl-3-hydroxyethyl imidazoline, and cocoacylaminoethyl hydroxyethyl lucarboxymethyl glycinate. The CTFA name of cocamidopropyl betaine, a well-known fatty acid amide derivative, is particularly preferred. Amphoteric surfactants are also suitable emulsifiers. Amphoteric surfactants are surface-active compounds that contain at least one free amino group and at least one -COOH- or -SO H- group in addition to the alkyl or acyl group and can form an inner salt within the molecule. Examples of suitable amphoteric surfactants are approximately N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N- hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N- alkyl or acyl group, and in addition, contain at least one free amino group and at least one -COOH- or -SO 8 / 18 group in the molecule and are surface-active compounds capable of forming an inner salt. H- group in the molecule and 3 are surface-active compounds capable of forming an inner salt within the molecule. Examples of suitable amphoteric surfactants are approximately N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N- hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N- alkyl glycine, N-alkyl propionic acid, N-alkyl amino butyric acid, N-alkyl imino dipropionic acid, N- hydroxyethyl-N-alkyl amide propyl glycine, N-alkyl taurine, N- hydroxyethyl-N-alkylamidepropylglycine, N-alkyltaurine, N- Alkyl sarcosine, 2-alkylaminopropionic acid and alkylaminoacetic acid . Particularly preferred amphoteric surfactants are N-cocoalkylaminopropionate, cocoacyl aminoethylaminopropionate and C 12 / 18 acyl sarcosine.
[0298] Surfactant: The cosmetic or pharmaceutical composition according to the present invention preferably contains one or more anionic and / or amphoteric or zwitterionic surfactants. Typical examples include the following: almond amidopropylamine oxide, almond amidopropyl betaine, aminopropyl lauryl glutamate, ammonium C12-15 alkyl sulfate, ammonium C12-16 alkyl sulfate, ammonium capryleth sulfate, ammonium cocomonoglyceride sulfate, ammonium coco-sulfate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, ammonium C12-15 pareth sulfate, ammonium C9-10 perfluoroalkyl sulfonate, dinonyl sulfosuccinate ammonium, ammonium dodecylbenzene sulfonate, ammonium isostearate, ammonium laures-6 carboxylate, ammonium laures-8 carboxylate, ammonium laures sulfate, ammonium laures-5 sulfate, ammonium laures-7 sulfate, ammonium laures-9 sulfate, ammonium laures-12 sulfate, lauroyl sarcosine (Ammonium Capryleth sulfate), ammonium cocomonoglyceride sulfate (Ammonium Cocomonoglyceride sulfate), ammonium coco-sulfate Ammonium cinnamate, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myreth sulfate, ammonium myristyl sulfate, ammonium nonoxynol-4 sulfate, ammonium nonoxynol-30 sulfate, ammonium oleate, ammonium palm kernel sulfate, ammonium stearate, ammonium tartrate, AMPD-isostearoyl hydrolyzed collagen (AMPD-lsostearoyl Hydrol yzed Collagen), AMPD-rosin hydrolyzed collagen, AMP-isostearoyl hydrolyzed collagen, AMP-isostearoyl hydrolyzed keratin, AMP- isostearoyl hydrolyzed soybean protein, AMP-isostearoyl hydrolyzed wheat protein, amido propyl betaine, arachidic acid, hexyl decyl phosphate arginine, avocado amido propyl betaine, avocado oil glyceryl-8 ester, babassu acid, babassu amido propyl amine oxide, babassu amido propyl betaine, beeswax acid, behenamide propyl betaine, behenamine oxide, behenes-25, behenes- 30, behenic acid, behenyl betaine, bis-butyl dimethicone polyglyceryl-3, butoxy nol-5 carboxylic acid, butoxynol-19 carboxylic acid, butyldimonium hydroxy propyl butyl glucoside chloride, butyldimonium hydroxypropyl lauryl glucoside chloride, butyl glucoside, butyl caprate glucoside, butyl glucoside hydroxypropyl trimonium chloride, butyl octanoic acid, C18-36 acid, C2 0-40 acid, C30-50 acid, C16-22 acid amide MEA, calcium dodecyl benzene sulfonate, calcium lauroyl taurate, C9-16 alkane / cycloalkane , C10-14 alkylbenzene sulfonic acid, C12-14 alkyldiaminoethyl gly cine HCL, C9-15 alkyl phosphate, Candida Bombicola / glucose / rapeseed oil fatty acid methyl ferment, canolamidopropyl betaine (Can olamidopropyl Betaine), capric acid, caproic acid, caproyl ethyl glucoside, (capryl / capramid) propyl betaine, capryles-4 carbo nic acid, capryles-6 carboxylic acid, capryles-9 carboxylic acid, caprylic acid, caproyl l collagen amino acid, caproyl glycine, caproyl hydrolyzed collagen, cap ryl hydrolyzed keratin, caproyl keratin amino acid, caproyl silk amino acid, caprylyl / capryl glucoside, caprylyl / capryl wheat bran / straw oside, caprylyl glucoside, caprylyl glyceryl ether, caprylyl pyrrolid ine, carnitine, cetearyl-20, cetearyl-23, cetearyl-24, cetearyl -25, cetearyl-27, cetearyl-28, cetearyl-29, cetearyl-30, cetearyl-33, cetearyl-34, cetearyl-40, cetearyl-50, cetearyl -55, cetearyl-60, cetearyl-80, cetearyl-100, cetearyl-2 5 carboxylic acid, cetearyl-2 phosphate, cetearyl-4 phosphate, cetearyl-5 phosphate, cetearyl-10 phosphate, cetes-20, cetes-23, cetes-24, cetes-25, cetes-30, cetes-40, cetes-45, cetes-150, cetes-8 phosphate, cete s-10 phosphate, cetes-20 phosphate, cetores-22, cetores-24, cetores-2 5. Cetyl Betaine, Chrysanthemum Sinense Flower Extract, C12 - 14 Hydroxyalkyl Hydroxyethyl Beta - Alanine, C12 - 14 Hydroxyalkyl Hydroxyethyl Sarcosine, Cocamidopropyl Betaine, Cocami dopropylamine Oxide, Cocamidopropyl Betaine Amide MEA Chloride, Cocamid opropyl Betaine, Cocamidopropyl Hydroxy Sulfate, Cocamine Oxide, Cocaminobuty ric Acid, Cocaminopropionic Acid, Coceth - 7 Carboxylic Acid, Coceth - 4 Glucoside, Cocamine Dipropionate, Cocobetaine Amide Amphopropionate, Coco - Betaine, Cocodimo nium Hydroxypropyl Hydrolyzed Wheat Protein, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Barley Protein, Coco - Glucoside, Cocoglucoside Hydroxypropyl Trimonium Chloride, Coco - Hydroxy Sulfate, Coco - Morpholine Oxide, Palm Fatty Acid, Palm Oil Glycereth - 8 Ester, Coco / Oleamidopropyl Betaine, Coco - Sulfate, Coco / Sunflower Amidopropyl Betaine, Cocoyl Choline Methosulfate, Cocoyl Glutamic Acid, Cocoyl Hydrolyzed Collagen, Cocoyl Hydrolyzed Keratin, Cocoyl Hydrolyzed Wheat Protein, Cocoyl Hydrolyzed Egg Protein, Cocoyl Hydrolyzed Silk, Cocoyl Hydrolyzed Soy Protein, Cocoyl Hydrolyzed Barley Protein, Cocoyl Sarcosine, Corn Acid , Cottonseed Acid, Cottonseed Oil Glycereth - 8 Ester, C10 - 16 Paleth - 1, C10 - 16 Paleth - 2, C11 - 13 Paleth - 6, C11 - 13 Paleth - 9, C11 - 13 Paleth - 10 , C11 - 15 Paleth - 30, C11 - 15 Paleth - 40, C12 - 13 Paleth - 1, C 12 - 13 palmitates - 23, C12 - 14 palmitates - 5, C12 - 14 palmitates - 9, C13 - 15 palmitates - 21, C14 - 15 palmitates - 8, C20 - 22 palmitates - 30, C20 - 40 palmitates - 40, C20 - 40 palmitates - 95, C22 - 24 palmitates - 33, C30 - 50 pa lmitates - 40, C9 - 11 palmitates - 6 carboxylic acid, C9 - 11 palmitates - 8 carboxylic acid, C1 1 - 15 palmitates - 7 carboxylic acid, C12 - 13 palmitates - 5 carboxylic acid, C12 - 13 pa lmitates - 7 carboxylic acid, C12 - 13 palmitates - 8 carboxylic acid, C12 - 13 palmitates - 12 ca rboxylic acid, C12 - 15 palmitates - 7 carboxylic acid, C12 - 15 palmitates - 8 carboxylic acid, C1 2 - 15 palmitates - 12 carboxylic acid, C14 - 15 palmitates - 8 carboxylic acid, C6 - 10 pa lmitates - 4 phosphate, C12 - 13 palmitates - 2 phosphate, C12 - 13 palmitates - 10 phosphate, C1 2 - 15 palmitates - 6 phosphate, C12 - 15 palmitates - 8 phosphate, C12 - 15 palmitates - 10 phosphate, C12 - 16 palmitates - 6 phosphate, C4 - 18 perfluoroalkyl ethyl thiohi droxypropyltrimonium chloride, copauramide propyl betaine, DEA - C 12 - 13 alkyl sulfate, DEA - C12 - 15 alkyl sulfate, DEA - ceteareth - 2 phosphate, DEA - cetyl sulfate, DEA - coco amphodip ropionate, DEA - C12 - 13 palmitates - 3 sulfate, DEA - cyclocarboxy cylopropionate, DEA - dodecylbenzenesulfonate, DEA - isostearate , DEA - laureth sulfate, DEA - lauryl sulfate, DEA - linole ate, DEA - methyl myristate sulfonate, DEA - myristyl sulfate, DE A-Myristate, DEA-Myristyl Sulfate, DEA-Oleth-5 Phosphate , DEA-Oleth-20 Phosphate, DEA PG-Oleate, Deceth-7 Carboxylic Acid, Deceth-7 Glucoside, Deceth-9 Phosphate, Decylamine Oxide, Decyl Be taine, Decyl Glucoside, Decyl Tetradeceth-30, Decyl Tetradecylamine Ox ide, Lauramid-MEA Sulfosuccinate Diammonium, Lauryl Sulfosuccinate Dia mmonium, Oleamide PEG-2 Sulfosuccinate Diammonium, Dibutoxymethane, Di-C12-15 Pareth-2 Phosphate(Di-CI 2-15 Pareth-2 Pho sphate), Di-C12-15 Pareth-4 Phosphate, Di-C12-15 Pareth-6 Phos phate, Di-C12-15 Pareth-8 Phosphate, Di-C12-15 Pareth-10 Phosphate, Butane Tetracarboxylic Acid Didodecyl, Lauryl Sulfate Diethylamine, Sulfosuccinate Diethylhe xyl Sodium, Dihydroxyethyl C8-10 Alkoxypropylamine Oxide, Dihydroxyethyl C9-11 Alkoxypropylamine Oxide, Dihydroxyethyl C12-15 Alkoxypropylamine Oxide, Dihydroxyethyl Lukamine Oxide, Dihydroxyethyl Lauramine Oxide, Dihydroxyethyl Ste aramine Oxide, Dihydroxyethyl Tallowamine Oxide, Dimethicone PEG-7 Pho phate, Dimethicone PEG-10 Phosphate, Dimethicone PEG / PPG-7 / 4 Pho sphate, Dimethicone PEG / PPG-12 / 4 Phosphate, Dimethicone / Polyglycerin -3 Crosslinked Polymer, Dimethicone Propyl PG-Betaine, Dimyristyl Phosphate, Diole yl Amidoethyl Hydroxyethyl Monium Methosulfate, Hydrogenated Coconut Fatty Acid DIPA, Lanolin fatty acid DIPA, myristic acid DIPA, dipotassium caproyl glutamate , dipotassium lauryl sulfosuccinate, dipotassium undecylenoyl glutamate, babassu sodium amide MEA-sulfosuccinate, disodium capro amphodiacetate, capro disodium capro amphodipropionate, disodium caprylo amphodiacetate, caprylo disodium amphodipropionate, disodium capryloyl glutamate, cetearyls sodium sulfosuccinate, disodium cetyl phenyl ether disulfonate, cetyl sodium sulfosuccinate, disodium cocoamido MEA-sulfosuccinate, cocoamido sodium MIPA PEG-4 sulfosuccinate, disodium cocoamido MIPA-sulfosuccinate , disodium cocoamido PEG-3 sulfosuccinate, disodium coces-3 sulfosuccinate , disodium cocoamphocarboxyethyl hydroxypropyl sulfonate, disodium cocoamphodiacetate , disodium cocoamphodipropionate, coco- sodium glucoside sulfosuccinate, disodium coco-sulfosuccinate, cocoyl sodium butyl gluceth-10 sulfosuccinate, disodium cocoyl glutamate , disodium C12-14 pareth-1 sulfosuccinate, disodium C12-14 pareth-2 sulfosuccinate , disodium C12-15 pareth sulfosuccinate, disodium C12-14 disodium Sec-pareth-3 sulfosuccinate, disodium C12-14 Sec-pareth-5 sulfosuccinate, disodium C12-14 Sec-pareth-7 sulfosuccinate, disodium C12-14 Sec-pareth-9 sulfosuccinate, disodium C12-14 Sec-pareth-12 sulfosuccinate, disodium deceth-5 sulfosuccinate Lithium, disodium deceth-6 sulfosuccinate, decyl phenyl ether disulfonic acid Disodium, disodium dihydroxyethyl sulfosuccinyl undecylenate, ethylene dicocamide PEG-15 disulfate disodium, hydrogenated cottonseed glyceride sulfosuccinate disodium Disodium, disodium hydrogenated tallow glutamate, hydroxydesyl sorbitol citrate disodium Disodium isodecyl sulfosuccinate, disodium isostearamide MEA-sulfosuccinate Disodium isostearamide MIPA-sulfosuccinate Disodium isostearo amphodiacetate, disodium isostearo amphodipropionate Disodium isostearyl sulfosuccinate, disodium laneth-5 sulfosuccinate Disodium lauramide MEA-sulfosuccinate, disodium lauramide MIPA glycol sulfosuccinate Disodium lauramide PEG-2 sulfosuccinate, disodium lauramide PEG-5 sulfosuccinate Disodium laureth-5 carboxy amphodiacetate Disodium laureth-7 citrate, disodium laureth sulfosuccinate Disodium laureth-6 sulfosuccinate, disodium laureth-9 sulfosuccinate Disodium laureth-12 sulfosuccinate, disodium lauriminobis hydroxypropyl sulfonate Disodium lauriminodiacetate, disodium lauriminodipropionate Lithium, disodium lauriminodipropionate tocopheryl phosphate Disodium lauro amphodiacetate, disodium lauro amphodipropionate Disodium N-lauroyl aspartate Disodium sulfonate, disodium lauryl sulfosuccinate, myristamid MEA- Disodium sulfosuccinate, disodium nonoxynol-10 sulfosuccinate, ole Amide MEA-disodium sulfosuccinate, oleamide ΜIΡΑ-disodium sulfosuccinate di Sodium, oleamide PEG-2 disodium sulfosuccinate, oleoamphodipropio Sodium acid disodium salt, oleth-3 disodium sulfosuccinate, disodium oleyl phosphate Sodium, disodium oleyl sulfosuccinate, disodium palmitamid PEG-2 sulfosuccinate di Sodium, disodium palmitoleamide PEG-2 sulfosuccinate, PEG-4 cocamide MIPA-disodium sulfosuccinate, PEG-12 dimethicone Disodium sulfosuccinate, PEG-8 palm glyceride disodium sulfosuccinate, PPG-2-isodeseth-7 carboxy amphodiacetate disodium, ricinoleamide ME A-disodium sulfosuccinate, sitosterol-14 disodium sulfosuccinate, da Sodium disodium amphodiacetate, stearamid MEA-disodium sulfosuccinate, st Sodium steariminodipropionate, disodium stearoamphodiacetate, stearo Sodium stearyl glutamate, disodium stearyl sulfosuccinate, stearyl st Disodium sulfosuccinate, disodium 2-sulfolaurate, disodium 2-sulfopalmitin Acid disodium salt, disodium tallow amide MEA-sulfosuccinate, disodium tallow amide MEA- Disodium sulfosuccinate, disodium tallow amphodiacetate, disodium tallowiminodipropion Acid disodium salt, disodium tridecyl sulfosuccinate, Sodium, disodium undecylenamide MEA-sulfosuccinate, undecylenamide P Disodium EG-2 sulfosuccinate, disodium undecylenoyl glutamate, co Wheat germ amide MEA-sulfosuccinic acid disodium salt, wheat germ amide PEG-2 sul Fosuccinic acid disodium salt, disodium wheat germ amphodiacetate, di-TEA-cocamide Diacetate, di-TEA-oleamide PEG-2 sulfosuccinate, di-TEA-pa Lmitoyl aspartate, ditridecyl sodium sulfosuccinate, dodecyl benzene Sulfonic acid, erucamide propyl hydroxysultaine, ethylhexes-3 carboxylic Acid, ethyl PEG-15 cocoamine sulfate, glyceryl caprylether, hexyl Decanoic acid, hydrogenated coconut fatty acid, hydrogenated ranes-25, hydrogenated menhaden acid, hydrogenated palm oil Fatty acid, hydrogenated palm kernel amine oxide, hydrogenated tallow acid, hydrogenated tallow amine oxide, water Treated tallow betaine, hydrogenated tallow oil glutamate, hydrolyzed Candida Bombicola extract, hydroxycetes-60, hydroxy e Thylacetomonium PG-dimethicone, hydroxyethylbutylamine laurylsulfate Hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl hi Droxypropyl C12-15 alkoxypropylamine oxide, hydroxylated lauryl / hydroxymyristyl betaine, hydroxystearic acid, hydroxysuccinimide L C10-40 isoalkyl acid, hydroxysuccinimidyl C21-22 iso Alkyl acid, hydroxysultaine, IPDI / PEG-15 soybean amine oxide Sid copolymer, IPDI / PEG-15 soy ethonium ethosulfate copolymer, IPDI / PEG-15 soybean glycinate copolymer, isocetes-30, isolaure S-4 phosphate, isopolyglyceryl-3 dimethicone, isopolyglyceryl-3 dimethiconol -ol, isopropanolamine lanolate, isopropylamine dodecylbenzenesulfonate amine, isostearamidopropylamine oxide, isostearamidopropyl betaine, isostearamidopropylmorpholine oxide, isostearess-8, isostearess- 16, isostearess-22, isostearess-25, isostearess-50, isostear ic acid, isostearoyl hydrolyzed collagen, jojoba oil PEG-150 ester, ho joba wax PEG-80 ester, joba wax PEG-120 ester, laness- 20, laness-25, laness-40, laness-50, laness-60, laness-75, lano phosphoric acid, lauramidopropylamine oxide, lauramidopropyl betaine, lauramide propyl hydroxysultaine, lauramine oxide, lauraminopropionic acid, laurul dimonium hydroxypropyl decyl glucoside chloride, laurul dimonium hydroxy propyl lauryl glucoside chloride, laureth-16, laureth-20, laureth-2 1, laureth-23, laureth-25, laureth-30, laureth-38, laureth-4 0, laureth-3 carboxylic acid, laureth-4 carboxylic acid, laureth-5 carboxylic acid, lau reth-6 carboxylic acid, laureth-8 carboxylic acid, laureth-10 carboxylic acid, laureth- 11 carboxylic acid, laureth-12 carboxylic acid, laureth-13 carboxylic acid, laureth-1 4 carboxylic acid, laureth-17 carboxylic acid, laureth-6 citrate, laureth-7 citrate acid, laureth-1 phosphate, laureth-2 phosphate, laureth-3 phosphate, laureth-4 phosphate Acids, lauryl-7 phosphate, lauryl-8 phosphate, lauryl-7 tartrate, lauric acid (La urie Acid), lauriminobispropanediol, lauriminodipropionic acid, lauramphodipropionic acid, lauroyl-beta-alanine, lauroyl collagen amino acid, lauroyl ethyl trimonium methosulfate, lauroyl hydrolyzed collagen 、 lauroyl hydrolyzed elastin, lauroyl methyl glucamide, lauroyl sarcosine 、 lauroyl silk amino acid, lauryl betaine, lauryl dimethicone / polyglycerin -3 cross-linked polymer, lauryl dimonium hydroxypropyl coco glucoside chloride, la uryl glucoside, lauryl glucoside hydroxypropyl trimonium chloride, laur yl glycol hydroxypropyl ether, lauryl hydroxysultaine, lauryl malamide, lauryl methyl glucamide, lauryl / myristyl glycol hydroxypro pyl ether, lauryl / myristyl wheatgerm / straw glycoside, lauryl poly glyceryl-3 polydimethylsiloxyethyl dimethicone, lauryl pyrrolidone, lauryl sultaine, linoleic acid, linolenic acid, linseed fatty acid, coconut fatty acid lysine, macadamia seed oil glyceryl-8 ester, coceth sulfate magnesium, coco-sulfate magnesium, isododecyl benzene sulfonic acid magnesium, lauryl-11 carboxylic acid magnesium 、 lauryl sulfate magnesium, lauryl-5 sulfate magnesium, lauryl-8 sulfate magne sium, lauryl-16 sulfate magnesium, lauryl-3 sulfosuccinic acid magnesium, lauryl hydroxypropyl sulfonic acid magnesium, lauryl sulfate magnesium, coco yl methyl taurine magnesium, myreth sulfate magnesium, oleth sulfate magnesium, Cocoa alkyl sulfate (Mg / TEA), Mani Kuang clay, MEA-cocoate, MEA -laureth-6 carboxylate, MEA-lauryl sulfate, MEA-lauryl sulfate lufate, MEA PPG-6 laureth-7 carboxylate, MEA-PPG-8- stearate-7 carboxylate, MEA-undecylenate, Meroxapol 108, Meroxapol 174, Meroxapol 178, Meroxapol 254, Meroxapol 255, Meroxapol 258, Meroxapol 314, Methoxy PEG-450 amide Glutaryl succinimide, Methoxy PEG-450 amide hydroxysuccinimide l succinate, Methoxy PEG-450 maleimide, Methylmorpholine oxide, Mill Quamidopropylamine oxide, Milkamide propyl betaine, Minkamide propyl l amine oxide, Minkamide propyl betaine, MIPA C12-15 pareth sulfate Fat, MIPA-dodecylbenzenesulfonate, MIPA-lauryl sulfate , MIPA-lauryl sulfate, Mixed isopropanolamine lanolate, Mixed iso Propanolamine lauryl sulfate, Mixed isopropanolamine myristate, Morpholine oleate, Morpholine stearate, Miristic-3-carboxylic acid, Miristic-5-carboxylic acid rubonic acid, Myristalconium chloride, Myristamidopropylamine oxide, Myrist t amidopropyl betaine, Myristamidopropyl dimethylamine phosphate, Myrist midopropyl hydroxysultaine, Myristamidopropyl PG-dimonium chloride phosphate sulfate, Myristamine oxide, Myristaminopropionic acid, Myristic acid, Myrist Triethyltrimonium methosulfate, myristoyl glutamate, myristoyl Hydrolyzed collagen, myristoyl sarcosine, myristyl betaine, myristyl / cetyl amine oxide, myristyldimonium hydroxypropyl cocoglucoside chloride, myristyl glucoside, myristyl phosphate, nonoxynol-20, nonoxynol-2 3, nonoxynol-25, nonoxynol-30, nonoxynol-35, nonoxynol -40, nonoxynol-44, nonoxynol-50, nonoxynol-100, nonoxynol-120, nonoxynol-5 carboxylic acid, nonoxynol-8 carboxylic acid, nonoxynol-10 carboxylic acid, nonoxynol-3 phosphate, nonoxynol -4 phosphate, nonoxynol-6 phosphate, nonoxynol-9 phosphate , nonoxynol-10 phosphate, nonylnonoxynol-30, nonylnonoxy nol-49, nonylnonoxynol-100, nonylnonoxynol-150, nonyl nonoxynol-7 phosphate, nonylnonoxynol-8 phosphate, nonylnonono xynol-9 phosphate, nonylnonoxynol-10 phosphate, nonylnonoxyno l-11 phosphate, nonylnonoxynol-15 phosphate, nonylnonoxyno l-24 phosphate, triticum aestivum amide propyl betaine, octoxynol- 16, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-20 carboxylic acid , octyldodeceth-20, octyldodeceth-25, octyldodeceth-30, olea midopropylamine oxide, oleamidopropyl betaine, oleamidopropyl hydro Xystamine, oleamine oxide, oleic acid, oleoyl hydrolyzed collagen, o leoyl sarcosine, Ores-20, Ores-23, Ores-24, Ores-25, ole s-30, Ores-35, Ores-40, Ores-44, Ores-50, Ores-3 carbox ylic acid, Ores-6 carboxylic acid, Ores-10 carboxylic acid, oleoyl betaine, olivami dopropylamine oxide, olivamidopropyl betaine, olive oil fatty acid, olive oil fatty acid hydrolyzed wheat protein, Ophiopogon extract stearate, ozone ized Ores-10, ozone-oleic acid PEG-10, ozone-oleic acid PEG-14, ozonized polysorbate 80, palm oil fatty acid, palmamidopropyl betaine, palme s-2 phosphate, palmitamidopropylamine oxide, palmitamidopropyl betaine, palmitamine oxide, palmitic acid, palmitoyl collagen amino acid, palmitoyl glycine, palmitoyl hydrolyzed collagen, palmitoyl hydrolyzed milk protein, pal mitoyl hydrolyzed wheat protein, palmitoyl keratin amino acid, palmitoyl oli gopeptide, palmitoyl silk amino acid, palm kernel fatty acid, palm kernel amidopropyl be taine, peach kernel oil glyceres-8 ester, peanut oil fatty acid, PEG-10 castor oil 、PEG-40 castor oil, PEG-44 castor oil, PEG-50 castor oil, PEG-54 castor oil, PEG-55 castor oil, PEG-60 castor oil, PEG-80 castor oil, PE G-100 castor oil, PEG-200 castor oil, PEG-11 cocoamide, PEG-6 coca midophosphate, PEG-4 cocoamine, PEG-8 cocoamine, PEG-12 cocoamine, PEG-150 Dioctyldodecyl Sebacate, PEG-90 Diisostearate, PEG-75 Dilaurate 、PEG-150 Dilaurate, PEG-75 Dioleate, PEG-150 Dioleate 、PEG-75 Distearate, PEG-120 Distearate, PEG-150 Distearate 、PEG-175 Distearate, PEG-190 Distearate, PEG-250 Distearate, PEG-30 Glyceryl Cocoate 、PEG-40 Glyceryl Cocoate, PEG-78 Glyceryl Cocoate, PEG-80 Glyceryl Cocoate 、PEG-30 Glyceryl Isostearate, PEG-40 Glyceryl Isostearate 、PEG-50 Glyceryl Isostearate, PEG-60 Glyceryl Isostearate 、PEG-90 Glyceryl Isostearate, PEG-23 Glyceryl Laurate, PEG-30 Glyceryl Laurate 、PEG-25 Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl Soyate 、PEG-25 Glyceryl Stearate, PEG-30 Glyceryl Stearate, PEG-40 Glyceryl Stearate 、PEG-120 Glyceryl Stearate, PEG-200 Glyceryl Stearate, PEG-28 Glyceryl Tallowate 、PEG-80 Glyceryl Tallowate, PEG-82 Glyceryl Tallowate, PEG-130 Glyceryl Tallowate 、PEG-200 Glyceryl Tallowate, PEG-45 Hydrogenated Castor Oil, PEG-50 Hydrogenated Castor Oil 、PEG-54 Hydrogenated Castor Oil, PEG-55 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil 、PEG-80 Hydrogenated Castor Oil, PEG-100 Hydrogenated Castor Oil, PEG-200 Hydrogenated Castor Oil 、PEG-30 Hydrogenated Lanolin, PEG-70 Hydrogenated Lanolin, PEG-50 Hydrogenated Palmamide, Isostearic Acid 、 、 、 PEG-2, PEG-3 isostearate, PEG-4 isostearate, isostearyl PEG-6 isostearate, PEG-8 isostearate, PEG-10 isostearate, isostearyl PEG-12 isostearate, PEG-20 isostearate, PEG-30 isostearate PEG-40 isostearate, PEG-26 jojoba fatty acid, PEG- 40 jojoba fatty acid, PEG-15 jojoba alcohol, PEG-26 jojoba alcohol, PEG-40 jojoba alcohol, PEG-35 lanolin, PEG-40 lanolin, PEG-50 lanolin , PEG-55 lanolin, PEG-60 lanolin, PEG-70 lanolin, PEG-75 lanolin, PEG-85 lanolin, PEG-100 lanolin, PEG-150 lanolin, PEG-75 lanolin oil, PEG-2 lauramide, PEG-3 lauramine oxide, lauryl PEG-20 phosphate, PEG-32 laurate, PEG-75 laurate, lauric acid P EG-150, PEG-70 mango glyceride, PEG-20 mannitol laurate, PEG-8 methyl ether dimethicone, PEG-120 methyl glucose dioleate, PEG-80 methyl glucose laurate, PEG-120 methyl glucose trioleate , PEG-4 montanate, PEG-30 oleamine, PEG-20 oleate, oleyl PEG-23 oleate, PEG-32 oleate, PEG-36 oleate, oleic acid P EG-75, PEG-150 oleate, PEG-20 palmitate, PEG-150 polyglyceryl-2 tristearate , PEG / PPG-28 / 21 dimethicone acetate, PE G / PPG-24 / 18 butyl ether dimethicone, PEG / PPG-3 / 17 copolymer - 1. PEG / PPG-5 / 35 copolymer, PEG / PPG-8 / 55 copolymer, PE G / PPG-10 / 30 copolymer, PEG / PPG-10 / 65 copolymer, PEG / PPG-12 / 35 copolymer, PEG / PPG-16 / 17 copolymer, PEG / PP G-20 / 9 copolymer, PEG / PPG-20 / 20 copolymer, PEG / PPG-2 0 / 60 copolymer, PEG / PPG-20 / 65 copolymer, PEG / PPG-22 / 25 copolymer, PEG / PPG-28 / 30 copolymer, PEG / PPG-30-35 copolymer, PEG / PPG-30 / 55 copolymer, PEG / PPG-35 / 40 copo lymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copoly mer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copoly mer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copoly mer, PEG / PPG-20 / 22 methyl ether dimethicone, phosphoric acid PEG-26-P PG-30, PEG / PPG-4 / 2 propylheptyl ether, PEG / PPG-6 / 2 propylheptyl ether, PEG-7 / PPG-2 propylheptyl ether, PE G / PPG-8 / 2 propylheptyl ether, PEG / PPG-10 / 2 propylhep tyl ether, PEG / PPG-14 / 2 propylheptyl ether, PEG / PPG- 40 / 2 propylheptyl ether, ricinoleic acid PEG / PPG-10 / 2, ricino leic acid PEG / PPG-32 / 3, PEG-55 propylene glycol oleate, P EG-25 propylene glycol stearate, PEG-75 propylene glycol ste arate, PEG-120 propylene glycol sorbitan laurate, PEG-5 nata Nestol, PEG-10 rapeseed nestol, PEG-40 ricinoleamide, PEG -75 shea butter glyceride, PEG-75 Shorea butter glyceride, PEG- 20 sorbitan cocoate, PEG-20 sorbitan isostearate, lanolin fatty acid PEG-40 sorbitan, PEG-75 sorbitan lanolin fatty acid, PEG-10 sorbitan laurate, PEG-40 sorbitan laurate, PEG-44 sorbitan laurate, PEG-75 sorbitan laurate, PEG-80 sorbitan laurate, PEG- 20 sorbitan oleate, PEG-80 sorbitan palmitate, PEG stearate -40 sorbitan, PEG-60 sorbitan stearate, PEG-160 sorbitan triisostearate -40 soybean sterol, PEG-2 stearamide carboxylic acid, PEG-9 stearamide carboxylic acid, PEG-20 stearate, PEG stearate -23, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate -35 stearate, PEG-36 stearate, PEG-40 stearate, PEG-45 stearate -50 stearate, PEG-55 stearate, PEG-75 stearate, PEG-90 stearate -100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 stearyl phosphate -20 tartrate, PEG-50 beef tallow amide, PEG-2 beef tallow amide DEA, PEG-20 tallowate, PEG-66 trihydroxystearic acid, PEG -200 trihydroxystearic acid, PEG-60 glyceride of camellia oil fatty acid, peral -36 G-200 trihydroxystearic acid, PEG-60 glyceride of camellia oil fatty acid, peral Gon acid, pentadoxynol-200, phenes-6 phosphate, poloxamer 105 , poloxamer 108, poloxamer 182, poloxamer 183, poloxamer 184 , poloxamer 188, poloxamer 217, poloxamer 234, poloxamer 235 , poloxamer 237, poloxamer 238, poloxamer 288, poloxamer 334 , poloxamer 335, poloxamer 338, polyxamine 908, polyxamine 150 8, polydimethylsiloxane PEG / PPG-24 / 19 butyl ether silsesquioxane , polydimethylsiloxane PPG-13 butyl ether silsesquioxane, Polyglyceryl-6 caprate, Polyglyceryl-10 dilaurate, Heptacaprylic acid Polyglyceryl-20, Polyglyceryl-20 hexacaprylate, Polyglyceryl-2 lauryl ether , Polyglyceryl-10 lauryl ether, Polyglyceryl-20 octaisononanoate, Polyglyceryl-6 pentacaprylate, Polyglyceryl-10 pentacaprylate, , Polyglyceryl-3 polydimethylsiloxyethyl dimethicone, Tetracaprylic acid Polyglyceryl-6, Tetralauric acid Polyglyceryl-10, Tricaprylic acid poly Glyceryl-6, Trilauric acid Polyglyceryl-10, Polyquaternium-77, Poly Quaternium-78, Polyquaternium-79, Polyquaternium-80, Polyquaternium -81, Polyquaternium-82, Pomaderris Kumerahou flower / Leaf extract, Poria Cocos extract, Potassium abietoyl hydrolyzed collagen, Potassium babassu ate, Potassium behenate, Potassium C9-15 alkyl phosphate, Potassium C11-15 alkyl phosphate, Potassium C12-13 alkyl phosphate Potassium C12-14 alkyl phosphate, potassium caprate, caproyl gly cinate potassium, potassium caproyl hydrolyzed rice protein, castor oil fatty acid potassium, palm fatty acid potassium, cocooyl glutamate potassium, cocooyl glycine potassium , cocooyl hydrolyzed casein potassium, cocooyl hydrolyzed collagen potassium, cocooyl hydrolyzed corn protein potassium, cocooyl hydrolyzed keratin potassium, coco oyl hydrolyzed rye protein potassium, cocooyl hydrolyzed potato protein potassium , cocooyl hydrolyzed rice bran protein potassium, cocooyl hydrolyzed rice protein potassium , cocooyl hydrolyzed silk potassium, cocooyl hydrolyzed soybean protein potassium , cocooyl hydrolyzed wheat protein potassium, cocooyl hydrolyzed yeast protein potassium , cocooyl PCA potassium, cocooyl sarcosine potassium, cocooyl taurine potassium , potassium cornate, potassium cyclocarboxypropyl oleate, potassium di hydroxyethyl cocamine oxide phosphate, potassium dimethicone PEG-7 phosph ate, potassium dodecylbenzene sulfonate, potassium hempseedate, hydrogenated palm fatty acid potassium, partially hydrogenated palm oil fatty acid potassium, partially hydrogenated tallow fatty acid potassium, hydroxy stearic acid potassium, isostearic acid potassium, lanolin fatty acid potassium, la uric acid potassium, laures-3 carboxylic acid potassium, laures-4 carboxylic acid potassium , laures-5 carboxylic acid potassium, laures-6 carboxylic acid potassium, laures-10 carboxylic acid potassium, laures phosphate potassium, potassium lauroyl collagen amino acid , potassium lauroyl glutamate, potassium lauroyl hydrolyzed collagen, potassium lauroyl hydrolyzed pea protein, potassium lauroyl hydrolyzed soybean protein , potassium lauroyl PCA, potassium lauroyl pea amino acids, lauroyl s lucinic acid potassium, potassium lauroyl silk amino acids, potassium lauroyl wheat a mino acids, potassium lauryl phosphate, potassium lauryl sulfate, potassium linoleate, metal lic acid potassium, potassium cocoyl methyl taurine, potassium myristate, myristoyl glutamic acid potassium, potassium myristoyl hydrolyzed collagen, octoxynol- 12 potassium phosphate, potassium oleate, potassium oleoyl hydrolyzed collagen, o live oil fatty acid potassium, olive oil fatty acid hydrolyzed gliadin potassium, o live oil fatty acid hydrolyzed wheat gliadin potassium, (olive oil fatty acid / lauroyl) wheat amino acid potassium, olive oil fatty acid PCA potassium, palm fatty acid potassium, p almitic acid potassium, potassium palmitoyl hydrolyzed corn protein, potassium palmitoyl hydrolyzed gliadin potassium, potassium palmitoyl hydrolyzed wheat protein , potassium palmitoyl hydrolyzed sweet almond protein, potassium palmitoyl hydrolyzed wheat gliadin, palm kernel fatty acid potassium, peanut oil fatty acid potassium , rapeseed oil fatty acid potassium, potassium ricinoleate, safflower oil fatty acid potassium, soybean oil fatty acid potassium, potassium stearate, potassium stearate, potassium stearoyl hydrolyzed collagen, potassium toluate, beef tallow fatty acid potassium, potassium taurine, potassium lauryl taurine, potassium trideceth-3-carboxylate, potassium trideceth-3 car Potassium borate, potassium trideceth-4 carboxylate, potassium trideceth-7 carboxylate , potassium trideceth-15 carboxylate, potassium trideceth-19 carboxylate, potassium trideceth-6 phosphate, potassium trideceth-7 phosphate, potassium camellia fatty acid , potassium undecylenate, potassium undecylenoyl hydrolyzed collagen, potassium u ndecylenoyl hydrolyzed wheat protein, PPG-30-buteth-30, PPG-36- buteth-36, PPG-38-buteth-37, PPG-30-capryleth-4 phosphate , PPG-10 cetyl ether phosphate, PPG-2 C9-11 pareth-8, PP G-1-deceth-5, PPG-3-deceth-2 carboxylic acid, PPG-30 ethylhexeth -4 phosphate, PPG-20-glycereth-30, PPG-2 hydroxyethyl coco / isostearamide, PPG-2-isodeceth-8, PPG-2-isodeceth-10, PPG-2-isodeceth-18, PPG-2-isodeceth-25, PPG-4-isodec eth-10, propyltrimonium hydrolyzed collagen, quaternium-24, quaternium -52, quaternium-87, rapeseed oil fatty acid, rice bran oil fatty acid, rice bran glycereth -8 ester, ricinoleamidopropyl betaine, ricinoleic acid, ricinoleth-40, safflower oil fatty acid, Sapindus Oahuensis fruit extract, Saponar ia Officinalis root powder, saponin, potassium soap, potassium-containing soap base, soap base , potassium soap base, sesame oil glycereth-8 ester, sesamidopropylamine oxide, sesamidopropyl betaine, shea butter amidopropyl betaine, shea butter glycereth -8 ester, sodium arachidonate, sodium argano amphoacetate, astrocalcium Sodium ummulumur fat fatty acid, sodium avocado oil fatty acid, babass amphoacetate sodium Lithium, sodium babass oil fatty acid, sodium babass sulfate, sodium behenate, bis Sodium glycol ricinosulfosuccinate, sodium bis-hydroxyethylglycine Sodium bis-hydroxyethylglycinate coco-glucoside cross-linked polymer, sodium bis-hydroxyethylglycinate Lauryl-glucoside cross-linked polymer, bolaamido propyl PG-dimonium chloride sodium Sulfate, sodium butoxynol-12 sulfate, sodium butyl glucoside hydroxypropyl Phosphate, sodium (C13-17) alkane sulfonate, (C14- 18) alkane sulfonate, sodium C12-15 alkoxypropyl imi Nodipropionate, sodium C10-16 alkyl sulfate, sodium C11-15 alkyl sulfate Sodium, sodium C12-13 alkyl sulfate, sodium C12-15 alkyl sulfate Sodium, sodium C12-18 alkyl sulfate, sodium C16-20 alkyl sulfate, C9 -22 alkyl Sec sulfonate, sodium C14-17 alkyl Sec sulfonate Sodium, sodium caprinate, sodium capro amphoacetate, sodium capro amphohydroxy Propylsulfonate, sodium capro amphopropionate, caproylmethyl Taurate, sodium caprylate, sodium capryless-2 carboxylate Sodium, sodium capryless-9 carboxylate, sodium caprylo amphoacetate, capryloa Sodium amphohydroxypropyl sulfonate, sodium caprylo amphopropionate Sodium, sodium capryloyl glutamate, sodium capryloyl hydrolyzed wheat gluten Protein, Sodium Caprylyl PG-Sulfonate, Sodium Caprylyl Sulfonate, Castor Sodium Fatty Acid, Sodium Ceteareth-13 Carboxylate, Sodium Cetearyl Sulfate Sodium, Sodium Ceteth-13 Carboxylate, Sodium Cetyl Sulfate, Cocamidopropyl PG -Dimonium Chloride Phosphate Sodium, Sodium Cocaminopropionate, Cocs Sulfate Sodium, Sodium Cocs-30 Sulfate, Sodium Cocoa Butter Amphoacetate, Cocoa Sodium Butter Fatty Acid, Sodium Cocoa Amphoacetate, Sodium Cocoa Amphohydroxypropyl Sulfate Sodium, Sodium Cocoa Amphopropionate, Sodium Palm Fatty Acid, Nat rium Coco / Babassu / Angolensis Sulfate, Sodium Coco / Babassu Sulfate Sodium, Sodium Cocoglucoside Hydroxypropyl Phosphate, Sodium Cocoglucoside Hydroxypro pyl Sulfate, Sodium Cocoglucoside Tartrate, Sodium Cocoglyceryl Ether Sulfate Sodium, Sodium Coco / Hydrogenated Tallow Sulfate, Sodium Cocoylamino Diacetate, Cocoglyceryl Sulfate, Sodium Cocomonoglyceride Sulfate, Cocomonogly ceride Sulfate Sodium, Sodium Cocopropyl PG-Dimonium Chloride Phosphate, Coco-Sulfate Sodium, Sodium Cocosulfoacetate, Sodium Cocoyl Alaninate, Na trum Cocoyl Amino Acid, Sodium Cocoyl Collagen Amino Acid, Sodium Cocoyl Glutamate, Sodium Cocoyl Glutamate, Sodium Cocoyl Glycinate, (Palm Fatty Acid / Hydrogenated Tallow Fatty Acid) Glutamate Sodium, Sodium Cocoyl Hydrolyzed Collagen, Sodium Cocoyl Hydrolyzed Keratin, Sodium Cocoyl Hydrolyzed Cometa Protein, Sodium Cocoyl Hydrolyzed Silk, Sodium Cocoyl Hydrolyzed Soybean Protein, Sodium Cocoyl Hydrolyzed Sweet Almond Protein, Sodium Cocoyl Hydrolyzed Wheat Protein, Sodium Glutamate of Cocoyl Hydrolyzed Wheat Protein Sodium, Sodium Cocoyl Isethionate, Sodium Cocoyl Methylaminopropionate , Sodium Cocoyl Wheat Amino Acid, (Coconut Fatty Acid / Palm Fatty Acid / Sunflower Fatty Acid) Sodium Glutamate, Sodium Cocoyl Proline, Sodium Cocoyl Sarcosine Sodium, Sodium Cocoyl Taurine, Sodium Cocoyl Threonine, Sodium Cocoyl Wheat Amino Acid, Sodium Olefin (C12 - 14) Sulfonate, Olefin (C14 - 16) Sulfonate, Sodium Olefin (C14 - 18) Sulfonate Sodium, Sodium Olefin (C16 - 18) Sulfonate, Sodium Corn Amphopropionate , Sodium Cottonseed Amphoacetate, Sodium C13 - 15 Parex - 8 Butyl Phosphate Sodium, Sodium C9 - 11 Parex - 6 Carboxylate, Sodium C11 - 15 Parex - 7 Carboxylate Sodium, Sodium C12 - 13 Parex - 5 Carboxylate, Sodium C12 - 13 Parex - 8 Carboxylate Sodium, Sodium C12 - 13 Parex - 12 Carboxylate, Sodium C12 - 15 Parex - 6 Carboxylate, Sodium C12 - 15 Parex - 7 Carboxylate, Sodium C12 - 15 Parex - 8 Carboxylate, Sodium C14 - 15 Parex - 8 Carboxylate, Sodium C12 - 14 Sec - Parex - 8 Carboxylate, Sodium C14 - 15 Parex - PG Sulfonate Sodium, Sodium C12 - 13 Parex - 2 Phosphate, Sodium C13 - 15 Parex - 8 Phosphate, Sodium C9 - 15 Parex - 3 Sulfate, Sodium C10 - 15 Parex Sulfate Thorium, Sodium C10-16 Pareth-2 Sulfate, Sodium C12-13 Pareth Sulfate , Sodium C12-15 Pareth Sulfate, Sodium C12-15 Pareth-3 Sulfate, C13 -15 Pareth-3 Sulfate, Sodium C12-14 Sec-Pareth-3 Sulfate, Sodium C12-15 Pareth-3 Sulfonate, Sodium C12-15 Pareth-7 Sulfonate Sodium, Sodium Deceth-2 Carboxylate, Sodium Deceth Sulfate, Sodium Decylbenzene Sulfonate, Decyl Glucoside Sodium Hydroxypropyl Phosphate, Sodium Decyl Glucoside Hydroxypropyl Sulfonate , Sodium Dilauryl-7 Citrate, Sodium Dilauryl-10 Phosphate, Sodium N-Dilinoleamidopropyl PG-Dimonium Chloride Phosphate, Dilinoic Acid Sodium, Sodium Dioleyl-8 Phosphate, Sodium Dodecylbenzene Sulfonate , Sodium Ethyl 2-Sulfolaurate, Sodium Glyceryl Oleate Phosphate , Sodium N-Budseed Amidopropyl PG-Dimonium Chloride Phosphate, Bud Seed Amphoacetate Sodium, Sodium Budseed Oil Fatty Acid, Sodium Hempseed Amphoacetate Sodium, Sodium Hexeth-4 Carboxylate, Sodium Hydrogenated Palm Fatty Acid, Hydrogenated Cocoyl Methyl Isethionate Sodium, Sodium Partially Hydrogenated Palm Oil Fatty Acid, Partially Hydrogenated Tallow Fatty Acid Sodium, Sodium Hydrogenated Tallow Glutamate, Hydroxylauryl Dimonium Ethyl Phosphate Sodium, Sodium Hydroxypropyl Carnate Sulfonate , Sodium Hydroxypropyl Phosphate Decyl Glucoside Crosslinked Polymer, Sodium Hydroxypropyl Phosphate Decyl Glucoside Crosslinked Polymer, Sodium Umb hydroxypropyl phosphate lauryl glucoside cross-linked polymer, sodium hydro xypropyl sulfonate coco glucoside cross-linked polymer, sodium hydroxypropyl sulfonate decyl glucoside cross-linked polymer, sodium hydroxypropyl sulfone ate lauryl glucoside cross-linked polymer, sodium hydroxystearate, isostear yl phosphate sodium, isostearic acid-6-carboxylic acid sodium, isostearic acid-11-car boxylic acid sodium, isostearo amphoacetic acid sodium, isostearo amphopropio nic acid sodium, sodium N-isostearyl methyl taurate, laneth sulfate sodium m, lanolin fatty acid sodium, sodium lardate (Sodium Lardate ), sodium lauramido diacetate, sodium lauraminopropionate, sodium laurate um, lauryl-3-carboxylic acid sodium, lauryl-4-carboxylic acid sodium, laur yl-5-carboxylic acid sodium, lauryl-6-carboxylic acid sodium, lauryl-8-car boxylic acid sodium, lauryl-11-carboxylic acid sodium, lauryl-12-carboxylic acid na trium, sodium lauryl-13-carboxylate, sodium lauryl-14-carboxylate, lauryl -16-carboxylic acid sodium, lauryl-17-carboxylic acid sodium, lauryl sulfate sodium m, sodium lauryl-5 sulfate, sodium lauryl-7 sulfate, sodium lauryl-8 sulfate sodium, sodium lauryl-12 sulfate, sodium lauryl-40 sulfate, lauryl -7 sodium tartrate, sodium lauriminodipropionate, sodium lauro amphoacetate um, sodium lauro ampho hydroxypropyl sulfonate, sodium lauro ampho PG-acetate Sodium phosphate, sodium lauroamphopropionate, sodium lauroyl aspartate Sodium lauroyl collagen amino acid, sodium lauroyl glycine propionate Sodium lauroyl hydrolyzed collagen, sodium lauroyl hydrolyzed Silk, sodium lauroyl hydroxypropyl sulfonate, sodium lauroyl isethionate Sodium lauroyl methyl aminopropionate, sodium lauroyl methyl isethionate Sodium lauroyl myristoyl aspartate, sodium lauroyl / Sodium lauroyl calspase amino acid, lauroyl Sodium sarcosinate, sodium lauroyl silk amino acid, lauroyl taurate Sodium lauroyl wheat amino acid, sodium lauryldiethylenediaminoglycine Sodium lauryl glucose carboxylate, sodium lauryl glucoside hydroxypropyl phosphate, hydroxypropyl sulfonic acid lauryl glucoside Sodium, lauryl glycol carboxylate, lauryl hydroxyacetamide sulfate Sodium lauryl phosphate, sodium lauryl sulfate, sodium lauryl sulfacetate Sodium linoleate, sodium macadamia seed oil fatty acid, sodium mango -amphoacetate, sodium mango seed oil fatty acid, sodium / MEA lauryl -2-sulfosuccinate, sodium methoxy PPG-2 acetate, methyl cocoyl Taurate, sodium methyl lauroyl taurate, sodium methyl myristoyl taurate Sodium oleoyl methyl taurate, sodium palmitoyl methyl tau Phosphate, sodium stearoyl methyl taurate, methyl-2-sulfolaur Phosphate Sodium riluate, sodium methyl-2-sulfopalmitate, sodium methyl taur rate isopalmitamide, sodium methyl taurine cocoil methyl taurate, mileth Sodium sulfate, sodium myristate, sodium myristoamphoacetate, myri stoyl glutamate sodium, sodium myristoyl hydrolyzed collagen, natri um myristoyl isethionate, sodium myristoyl sarcosinate, myristyl sulf ate sodium, nonoxynol-6 phosphate sodium, nonoxynol-9 phosphate natri um, nonoxynol-1 sulfate sodium, nonoxynol-3 sulfate sodium, nonoxik sinol-4 sulfate sodium, nonoxynol-6 sulfate sodium, nonoxynol-8 sulfate sodium, nonoxynol-10 sulfate sodium, nonoxynol-25 sulfate nat rium, octoxynol-2 ethane sulfonate sodium, octoxynol-2 sulfate sodium, octoxynol-6 sulfate sodium, octoxynol-9 sulfate sodium natri um, sodium oleate, oleoamphoacetate sodium, oleoamphohydroxypro pylsulfonate sodium, sodium oleoamphopropionate, sodium ole oil hydrolyzed collagen, oleoyl isethionate sodium, oresulfate sodium 、sodium oleyl methyl isethionate, sodium oleyl sulfate, olive amph acetate sodium, sodium olive fatty acid, sodium olive oil fatty acid glutamate 、sodium palm amphoacetate, sodium palm fatty acid, sodium palm glyceryl sulfonate sodium, sodium palmitate, sodium palmitoyl hydrolyzed collagen, na Tritium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosinate , sodium palm kernel fatty acid, sodium palm carneloyl isethionate, palm fat sodium glutamate, sodium Passiflora Edulis seed oil fatty acid sodium, sodium peanut amphoacetate, sodium peanut oil fatty acid, PEG-6 coco amidocarboxylic acid sodium, PEG-8 cocoamidocarboxylic acid sodium, PEG-4 coco amid sulfate sodium, PEG-3 lauramidocarboxylic acid sodium, PEG-4 laurami docarboxylic acid sodium, PEG-8 palm glyceride carboxylic acid sodium, sodium pentaerythrityl hydroxypropyliminodiacetate dendrimer (P entaerythrityl Hydroxypropyl lminodiacet ate Dendrimer), sodium propoxy PPG-2 acetate, rapeseed oil sodium fatty acid, sodium rice bran amphoacetate, sodium ricinoleate, sodium muricinoleo amphoacetate, sodium rose hip amphoacetate, sodium abietic acid sodium, sodium safflower oil fatty acid, sodium safflower oil hydrolyzed soybean protein , sodium sesame seed oil fatty acid, sodium sesame amphoacetate, sodium shea butter amphoacetate sodium, sodium soybean oil fatty acid, sodium soybean hydrolyzed collagen, stearic acid sodium, sodium stearoamphoacetate, sodium stearoampho hydroxyprop yl sulfonate, sodium stearoamphopropionate, sodium stearoyl casein sodium, sodium stearoyl glutamate, sodium stearoyl hyaluronate sodium, sodium stearoyl hydrolyzed collagen, sodium stearoyl hydrolyzed corn Corn protein, sodium stearoyl hydrolyzed silk, sodium stearoyl Hydrolyzed soybean protein, sodium stearoyl hydrolyzed wheat protein, stear oyl lactalbumin sodium, sodium stearoyl methyl isethionate, st earoyl gliadin sodium, stearoyl pea protein sodium, stearoyl soybean protein sodium , sodium stearyl dimethyl glycine, sodium stearyl sulfate, sodium sunflower seed amphoacetate, sodium surfactin , sodium sweet almond amphoacetate, sodium sweet almond oil fatty acid sodium, sodium tall amphopropionate, sodium tartrate, sodium tallow amphoacetate, sodium beef tallow fatty acid, sodium tallow sulfate, sodium tamanu seed oil fatty acid sodium, sodium taurate, sodium cocoyl methyl taurate taurate sodium , sodium laurate taurate, sodium / TEA-lauroyl collagen amino acid, sodium / TEA-lauroyl hydrolyzed collagen, sodium / TEA-lauro yl hydrolyzed keratin, sodium / TEA-lauroyl keratin amino acid, sodium / TEA-undecylenoyl collagen amino acid, sodium / TEA-undecylenoyl hydrolyzed collagen, sodium / TEA-undecylenoyl hydrolyzed corn protein, sodium / TEA-undecylenoyl hydrolyzed soybean protein, sodium / TEA-undecylenoyl hydrolyzed wheat protein, Theobroma Gran diflorum seed oil fatty acid sodium, sodium trideceth-3 carboxylate, tri deceth-4 carboxylate, sodium trideceth-6 carboxylate, trideceth- 8 carboxylate sodium Sodium 7-carboxylate, sodium trideceth-8-carboxylate, trideceth-12-car boxylate, sodium trideceth-15-carboxylate, sodium trideceth-19-carbox ylate, sodium trideceth sulfate, sodium tridecylbenzenesulfonate, sodium tridecyl sulfate, sodium trimethylolpropane hydroxypropyl imi nodiacetate dendrimer, sodium undeceth-5-carboxylate, sodium undecylenate sodium, sodium undecylen amphoacetate, sodium undecylen amphopropionate sodium, sodium undecenoyl glutamate, sodium wheat germ amphoacetate, sor beth-160 stearate, soybean oil fatty acid, soyamidopropylamine oxide, da izamidopropyl betaine, soybean oil glycereth-8 ester, stearamidopro pylamine oxide, stearamidopropyl betaine, stearamine oxide, stearate -15, stearate-16, stearate-20, stearate-21, stearate-25 , stearate-27, stearate-30, stearate-40, stearate-50, stear ate-80, stearate-100, stearate-2 phosphate, stearate-3 phosphate, st earate phosphate, stearoxypropyltrimonium chloride, stearoyl glutamate, s tearoyl sarcosine, stearyl betaine, stearyldimonium hydroxypropyl butyl glucoside chloride, stearyldimonium hydroxypropyl decyl glucoside chloride, stearyldimonium hydroxypropyl lauryl glucoside chloride, sulfuric acidated castor oil, sulfated coconut oil, sulfated glycerol oleate, sulfated olive oil, sulfated p - Nut oil, sunflower amide MEA, sunflower seed oil fatty acid, sunflower seed amide propyl hydroxyethyl dimonium chloride, sunflower seed oil glycereth - 8 ester, tall oil acid, tallow fatty acid, tallow amide propylamine oxide, tallow amide propyl betaine, tallow amide propyl hydroxysultaine, tallow amine oxide, tallow betaine, tallow dihydroxyethyl betaine, tallow oil ethyl glucoside, TEA - abietoyl hydrolyzed collagen, TEA - C12 - 14 alkyl phosphate, TEA - C10 - 1 5 alkyl sulfate, TEA - C11 - 15 alkyl sulfate, TEA - C12 - 13 alkyl sulfate, TEA - C12 - 14 alkyl sulfate, TEA - C 12 - 15 alkyl sulfate, TEA C14 - 17 alkyl Sec sulfonate, TEA - canolate, TEA - cocamidodiacetate, TEA - coconut fatty acid, TEA - coco - sulfate, TEA - cocoyl alanine, TEA - cocoyl glutamate, TEA - cocoyl glutamine, TEA - cocoyl glycine, TEA - cocoyl hydrolyzed collagen, TE A - cocoyl hydrolyzed soybean protein, TEA - cocoyl sarcosine, TEA - dimethicone PEG - 7 phosphate, TEA - dodecylbenzene sulfonate, TEA - hydrogenated coco ate, hydrogenated tallow glutamate TEA, TEA - isostearate, TEA - isostear oyl hydrolyzed collagen, TEA - lauraminopropionate, TEA - laurate, (Lauric acid / myristic acid)TEA, TEA - lauryl sulfate, lauroyl collagen amino acid TEA, lauroyl glutamate TEA, TEA - lauroyl hydrolyzed collagen, TEA - lauroyl keratin amino acid, TEA - lauroyl methylaminopropionate, TEA-lauroyl / myristoyl aspartate, lauroyl sarcosine TEA, TE A-lauryl phosphate, lauryl sulfate TEA, TEA-myristaminopropionate , TEA myristate, TEA-myristoyl hydrolyzed collagen, TEA-oleate , TEA-oleoyl hydrolyzed collagen, TEA-oleoyl sarcosinate, olei l sulfate TEA, TEA palmitate, TEA-palm kernel sarcosinate, PEG-3 coca mid sulfate TEA, TEA-resinate, TEA stearate, TEA-tarate, TEA -tridecylbenzenesulfonate, TEA undecylenate, TEA-undecylenoyl hydrolyzed collagen, tetramethyldecanediol, tetrasodium dicarboxyethi l stearyl sulfosuccinate, laureth sulfate TIPA, TIPA-lauryl sulf ate, TIPA myristate, TIPA-stearate, tocopheryl phosphate, und silenic acid trehalose, TM-C12-15 pareth-2 phosphate, TM-C12-1 5 pareth-6 phosphate, TM-C12-15 pareth-8 phosphate, TM-C12 -15 pareth-10 phosphate, trideceth-20, trideceth-50, trideceth- 3 carboxylic acid, trideceth-4 carboxylic acid, trideceth-7 carboxylic acid, trideceth-8 carboxylic acid, trideceth-15 carboxylic acid, trideceth-19 carboxylic acid, trideceth- 10 phosphate, tridecylbenzenesulfonic acid, trilauryl-9 citrate, tri methylolpropane hydroxypropylbis-hydroxyethylamine dendrimer, tri lithium lauroampho PG-acetate chloride phosphate, undecanoic acid, und Decess-5-carboxylic acid, undecylenamide propylamine oxide, undecylenamide propyl betaine, undecylenic acid, undecenoyl collagen amino acid, undeceno yl glycine, undecylenoyl hydrolyzed collagen, undecenoyl wheat amino acid, undecyl glucoside, wheat germ oil fatty acid, wheat germ amide propylamine oxide , wheat germ amide propyl betaine, Yucca Schidigera leaf / root / stem extract , Yucca Schidigera stem extract, zinc coco sulfate and lead coco sulfate.
[0299] Preservative: For preservation purposes, the cosmetic or pharmaceutical composition according to the present invention preferably contains one or more preservatives suitable or conventional for cosmetic or pharmaceutic...
Claims
1. A cosmetic, or pharmaceutical composition, or home care product comprising or consisting of: (a) at least one linear alkanediol having a carbon chain of from 5 to 14 carbon atoms, or at least one first linear alkanediol having a carbon chain of from 5 to 14 carbon atoms, and one or more second linear alkanediols having a carbon chain of from 5 to 14 carbon atoms, different from a mixture comprising the first linear alkanediol; (b) at least one natural polymer; and (c) optionally at least one active substance and / or additive for a cosmetic or pharmaceutical composition or home care product, A mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, A mixture comprising 1,2-hexanediol and 2,3-hexanediol; A mixture comprising 1,2-octanediol and 2,3-octanediol; A mixture comprising 1,2-hexanediol and 2,3-octanediol; Mixture containing 1,2-octanediol and 2,3-hexanediol A cosmetic, or pharmaceutical composition, or home care product selected from the group consisting of:
2. 2. The cosmetic, or pharmaceutical composition, or home care product of claim 1, wherein the linear alkanediol is selected from the group consisting of 2,3-hexanediol, 2,3-octanediol, and mixtures thereof.
3. 2. A cosmetic, or pharmaceutical composition, or home care product according to claim 1, wherein the mixture comprising one or more second linear alkanediols comprises the first linear alkanediol and the second alkanediol in a ratio ranging from 50:50 to 99.9:0.1, preferably in a ratio ranging from 75:25 to 99:1, with a ratio ranging from 80:20 to 98:2 being more preferred, and even more preferred with a ratio ranging from 90:10 to 95:
5.
4. The at least one natural polymer is selected from the group consisting of natural gums, starch, cellulose and their derivatives, hyaluronic acid, pectin, collagen, gelatin, chitosan, keratin, hectorite, and mixtures of the aforementioned natural polymers, in particular Natural gum, natural gums, preferably obtained from seaweed, in particular agar, algin (alginic acid) or carrageenan; natural gums, preferably obtained from non-marine plant sources, in particular gum arabic (acacia senegal gum), gum ghatti, gum tragacanth, gum karaya, guar gum, locust bean gum, beta-glucan, damar gum, galactomannan, glucomannan, psyllium seed husk or tara gum; natural gums, preferably produced by bacterial fermentation, in particular gellan gum, xanthan gum or sclerotium gum; and mixtures of two or more of the foregoing gums; and / or Starch: Wheat starch, rice starch, maize starch, zea mays starch, tapioca starch, potato starch, cassava starch, acorn starch, arrowroot starch, arracacha starch, banana starch, barley starch, breadfruit starch, buckwheat starch, canna starch, taro starch, dogtooth violet starch, kudzu starch, malanga starch, millet starch, oat starch, oka starch, Polynesian arrowroot starch, sago starch, sorghum starch, sweet potato starch, rye starch, taro starch, chestnut starch, water chestnut starch, yam starch, bean starch, pea starch, physically, chemically or enzymatically modified starches, and mixtures of two or more of the foregoing starches; and / or 4. The cosmetic, or pharmaceutical composition, or home care product according to claim 1, wherein the cellulose or a derivative thereof is selected from the group consisting of microcrystalline cellulose, cellulose gum, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, and mixtures of two or more of the aforementioned celluloses or cellulose derivatives; and mixtures of two or more of the aforementioned natural gums.
5. 5. The cosmetic, pharmaceutical composition or home care product according to claim 1 , wherein the at least one active substance and / or additive for the cosmetic, pharmaceutical composition or home care product is selected from the group consisting of agents against skin aging, antioxidants, chelating agents, emulsifiers, surfactants, preservatives, synthetic polymers, skin cooling agents, rheological additives, oils, fragrances or perfume oils, polyols, and mixtures of two or more of the aforementioned substances.
6. Caprylhydroxamic acid, o-cymen-5-ol, isopropylparaben, capryloyl glycine, phenylpropanol, tropolone, ethyl cocoyl arginate PCA, 2-methyl-5-cyclohexyl pentanol, phenoxyethanol, disodium EDTA, methylparaben and its salts, sodium benzoate, benzyl alcohol, potassium sorbate, benzyl salicylate, propylparaben, methylchloroisothiazolinone, methylisothiazolinone, ethylhexylglycerin, butylparaben , ethylparaben, propylparaben sodium, DMDM hydantoin, hydroxyethoxyphenylbutanone, hydroxyethoxyphenylbutanol, itaconic acid and its salts, octopirox, propanediol caprylate, climbazole, 4-hydroxyacetophenone, dehydroacetic acid, iodopropynyl butylcarbamate, salicylic acid, chlorphenesin, isobutylparaben, ethylparaben sodium, diazolidinyl urea, diazolidinyl urea, farnesol, bisabolol, caprylic acid Glyceryl, sodium phytate or phytic acid, sodium levulinate or levulinic acid and its esters, chlorhexidine, glyceryl laurate, anisic acid and its salts, chlorhexidine digluconate, TEA salicylate, phenethyl alcohol, glyceryl caprate, sorbitan caprylate, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, sodium lactate, undecylenoyl glycine, thymol, 1,3-propanediol, 4-hydroxybenzoic acid and its salts. salts and esters of, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan), 4-chloro-3,5-dimethyl-phenol, 2,2'-methylenebis(6-bromo-4-chlorophenol), 3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4-chloro-phenol, 3-(4-chlorophenoxy)-1,2-propanediol, 3-iodo-2-propynyl butylcarbamate, 3,4,6. The cosmetic, pharmaceutical composition, or home care product according to any one of claims 1 to 5, further comprising at least one antimicrobial agent selected from the group consisting of 4'-trichlorocarbanilide (TTC), antimicrobial fragrance, thymol, thyme oil, eugenol, clove oil, menthol, mint oil, glyceryl monocaprate, glyceryl monocaprylate, glyceryl monolaurate (GML), diglyceryl monocaprate (DMC), salicylic acid N-alkylamides such as n-octyl salicylamide or n-decyl salicylamide, dehydroacetic acid, 4-methylbenzyl alcohol, Frambinon, xylityl caprylate, benzoic acid 3-hydroxypropyl ester, anisic acid 3-hydroxypropyl ester, 2-hydroxybenzoic acid 3-hydroxypropyl, and mixtures of two or more of the aforementioned antimicrobial agents.
7. 7. A cosmetic, or pharmaceutical composition, or home care product according to any one of claims 1 to 6, comprising at least one linear alkanediol, or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, in an amount of 0.001 to 15.0 wt.-%, relative to the total weight of the composition or home care product, with an amount of 0.01 to 10.0 wt.-% being preferred, an amount of 0.5 to 1.0 wt.-% being more preferred, an amount of 0.3 to 3.0 wt.-% being even more preferred, and an amount of 0.5 to 1.0 wt.-% being most preferred.
8. 8. The cosmetic or pharmaceutical composition according to claim 1 , comprising at least one natural polymer in an amount of 0.01 to 25.0% by weight, in particular in an amount of 0.02 to 15.0% by weight, more in particular in an amount of 0.05 to 6.0% by weight, relative to the total weight of the composition or home care product.
9. (i) in the form of dispersions comprising an oil component in an amount of ≧1% by weight, in particular in an amount of ≧3% by weight, preferably in the form of emulsions, in particular O / W emulsions, W / O emulsions, multiple emulsions, water-dispersed gels, balms, multiple emulsions of the water-in-oil type (W / O / W) or oil-in-water type (O / W / O), PIT emulsions, Pickering emulsions, microemulsions, liquids, lotions, suspensions, milks, ointments, pastes, gels, cream-based, oil-based or liposome-based formulations; (ii) in the form of a liquid surfactant formulation; or (iii) in the form of an aqueous or aqueous / alcoholic, in particular aqueous / ethanolic or aqueous / glycolic, solution, containing an alcohol or glycol in an amount of 0.1% to ≦50% by weight, based on the total weight of the solution; In particular, the cosmetic or pharmaceutical composition according to any one of claims 1 to 8, wherein the cosmetic or pharmaceutical composition is a cryoformulated preparation.
10. 10. A cosmetic, or pharmaceutical composition, or home care product according to any one of claims 1 to 9, for personal care, in particular for the care of the skin, hair, scalp and nails, or as a pharmaceutical, or for animal husbandry; or home care products selected from the group consisting of liquid detergents, all-purpose cleaners, washing and cleaning agents, fabric softeners, laundry scents and laundry scent boosters.
11. Use of at least one linear alkanediol according to claim 1 or 2 or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols for reducing the antimicrobial load of a natural polymer, preferably a natural polymer according to claim 4, in particular in a cosmetic or pharmaceutical composition or home care product and / or as an antimicrobial substitute in a cosmetic or pharmaceutical composition or home care product comprising at least one natural polymer.
12. A method for reducing the antimicrobial load of a cosmetic or pharmaceutical composition or a home care product comprising a natural polymer, preferably a natural polymer according to claim 4, comprising: - preparing a cosmetic or pharmaceutical composition or a home care product comprising a natural polymer, preferably a natural polymer according to claim 4; and - incorporating an effective amount of at least one linear alkanediol or a mixture comprising at least one first linear alkanediol and one or more second linear alkanediols according to claim 1 or claim 2.
13. A mixture comprising at least one first linear alkanediol and one or more second linear alkanediols, A mixture comprising 1,2-hexanediol and 2,3-hexanediol; A mixture comprising 1,2-octanediol and 2,3-octanediol; A mixture comprising 1,2-hexanediol and 2,3-octanediol; Mixture containing 1,2-octanediol and 2,3-hexanediol The use according to claim 11 or the method according to claim 12, wherein the compound is selected from the group consisting of:
14. The use according to claim 11 or the method according to claim 12, wherein the linear alkanediol is selected from the group consisting of 2,3-hexanediol, 2,3-octanediol, and mixtures thereof.
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