Oral composition

Abstract

To provide an oral composition capable of effectively removing dental plaque formed as a biofilm.SOLUTION: An oral composition according to the present invention includes pulverized plant seeds. The oral composition according to the present invention preferably further includes silica. The pulverized plant seeds preferably have an average particle diameter of 50 μm or more and 1000 μm or less. The pulverized plant seeds are preferably pulverized coffee seeds. The silica preferably has an average particle diameter of 1 μm or more and 1000 μm or less.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition.

Background Art

[0002] In recent years, due to the growing awareness of SDGs (Sustainable Development Goals) such as environmental issues and the sustainability of resource utilization, there has been increasing interest in using natural-derived raw materials such as plants and natural minerals instead of petrochemical-derived raw materials.

[0003] By the way, dental plaque is known as one of the causes of dental caries and periodontal disease in the oral cavity. Dental plaque is a biofilm formed in the oral cavity and is a structure formed by microorganisms such as bacteria. Here, a biofilm generally refers to an aggregate of bacteria covered with a glycocalyx composed of extracellular polysaccharides, which adheres to the surface of a substance in a film-like manner.

[0004] As methods for removing biofilms, chemical removal using surfactants etc., biological removal using enzymes etc., and physical removal such as polishing using granules or ultrasonic waves are known (for example, Patent Documents 1 and 2). In Patent Document 1, a method for removing biofilms using an oral composition containing a sugar alcohol or an amino acid is shown. Further, in Patent Document 2, a method for removing dental plaque using silica granules starting from silicic acid is shown.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0006] However, conventional methods are unable to sufficiently remove dental plaque formed as a biofilm, and there is a demand for the development of an oral composition having an excellent dental plaque removal effect. Also, from the perspective of the SDGs, it is required to use naturally-derived raw materials for the purpose of removing dental plaque.

[0007] Therefore, an object of the present invention is to provide an oral composition capable of effectively removing dental plaque formed as a biofilm.

Means for Solving the Problems

[0008] The oral composition according to the present invention contains a pulverized plant seed.

Effects of the Invention

[0009] According to the present invention, it is possible to provide an oral composition capable of effectively removing dental plaque formed as a biofilm.

Modes for Carrying Out the Invention

[0010] Hereinafter, preferred embodiments of the oral composition of the present invention will be described in detail. The oral composition in this specification includes dentifrices such as paste dentifrices, moist dentifrices (gel dentifrices), powder dentifrices, liquid dentifrices, and liquid toothpastes, lozenges, tablets, creams, ointments, patches, mouthwashes, and chewing gums. Among these, the oral composition of the present invention is preferably applied to a paste dentifrice or a moist dentifrice (gel dentifrice).

[0011] The oral composition of the present invention contains a pulverized plant seed. Thereby, it is possible to provide an oral composition capable of effectively removing dental plaque formed as a biofilm. That is, the oral composition of the present invention functions as a biofilm remover.

[0012] <Pulverized plant seed> The oral composition of the present invention contains a pulverized plant seed. The pulverized plant seed is a pulverized product of a plant seed, and may be a product obtained by subjecting these pulverized products to processing such as drying, heating, roasting, etc. Further, a product obtained by adding a non-naturally derived portion by chemical synthesis or the like may be used as the pulverized plant seed, but in that case, it should be within the range defined as a natural raw material by ISO16218, that is, the range in which the non-naturally derived portion does not exceed 50% of the whole. In particular, it is preferable to use a pulverized coffee seed as the pulverized plant seed.

[0013] The average particle size of the pulverized plant seed used in the present invention is preferably 50 μm or more, more preferably 100 μm or more, still more preferably 200 μm or more, particularly preferably 300 μm or more, and even more preferably 350 μm or more. Thereby, biofilm (dental plaque) can be removed more effectively. Also, the average particle size of the pulverized plant seed is preferably 1000 μm or less, more preferably 750 μm or less, still more preferably 500 μm or less, and particularly preferably 450 μm or less. Thereby, the dispersion stability of the pulverized plant seed in the oral composition can be made better. For the measurement of the average particle size, for example, the d50% median diameter and the laser diffraction / scattering method can be used.

[0014] The content of the pulverized plant seed is preferably 0.01% by mass or more, more preferably 0.25% by mass or more, still more preferably 0.05% by mass or more, and particularly preferably 0.1% by mass or more. Thereby, biofilm (dental plaque) can be removed more efficiently. Also, the content of the pulverized plant seed is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 5% by mass or less, and particularly preferably 3% by mass or less. Thereby, the feel of use and the formulation stability of the oral composition can be made better.

[0015] As the coffee seeds used as the raw material for the ground coffee seeds, for example, Arabica seeds, Robusta seeds, mixtures thereof, etc., or generally available coffee seeds can be used. Further, as the coffee seeds, in addition to raw coffee beans before roasting, those that have undergone a roasting process may also be used. For the grinding process of the coffee seeds, general grinding methods such as a mill or a homogenizer may be used. Further, from the perspective of SDGs, as the ground coffee seeds, in addition to the ground product after roasting and grinding, residues (coffee extraction residue granules) that have undergone a process of extraction with hot water or the like after roasting and grinding may also be used. When using coffee extraction residue granules as the ground coffee seeds, in order to prevent the growth of microorganisms, it is desirable to add a step of drying the extraction residue to remove moisture. Further, after drying the extraction residue, the product additionally ground with a mill or a homogenizer or the like may be used as the ground coffee seeds.

[0016] <Silica> The oral composition of the present invention preferably contains silica in addition to the above plant seed powder. Thereby, the effect of removing dental plaque formed as a biofilm can be made more remarkable. As the silica, for example, anhydrous silicic acid, hydrous silicic acid, etc. can be used. Further, the silica is not limited to those of natural origin.

[0017] The average particle size of the silica is preferably 1 μm or more, more preferably 10 μm or more, and even more preferably 100 μm or more. Thereby, the biofilm (dental plaque) can be removed more effectively. Further, the average particle size of the silica is preferably 1000 μm or less, more preferably 500 μm or less, and even more preferably 300 μm or less. Thereby, the dispersion stability of the silica in the oral composition can be made better. For the measurement of the average particle size, for example, the d50% median diameter, the laser diffraction / scattering method can be used.

[0018] The silica content is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, still more preferably 0.05% by mass or more, and particularly preferably 0.1% by mass or more. Thereby, biofilm (dental plaque) can be removed more efficiently. Also, the silica content is preferably 50% by mass or less, more preferably 20% by mass or less, still more preferably 10% by mass or less, and particularly preferably 5% by mass or less. Thereby, the feel of use and formulation stability of the oral composition can be made better.

[0019] When the content of the pulverized plant seed is taken as 1, the silica content is preferably 0.001 or more, more preferably 0.0025 or more, still more preferably 0.01 or more, and particularly preferably 0.03 or more. Also, when the content of the pulverized plant seed is taken as 1, the silica content is preferably 5000 or less, more preferably 800 or less, still more preferably 200 or less, and particularly preferably 50 or less. Thereby, biofilm (dental plaque) can be removed even more efficiently.

[0020] The oral composition of the present invention can contain optional components usually used in oral compositions, if necessary. Examples of the optional components include bactericides, surfactants, abrasives, thickeners, wetting agents, solvents, sweeteners, fragrances, cooling agents, pH adjusters, preservatives, colorants, suspending agents, functional components, flavoring components, and the like. Note that the oral composition of the present invention can also be prepared as an oral composition without an abrasive. These optional components can be appropriately selected within a range that does not impair the effects of the present invention, and the optional components can be blended in appropriate amounts. These optional components may have a plurality of characteristics (for example, fragrance and cooling agent) in one compound.

[0021] As the bactericide, for example, a cationic bactericide, a nonionic bactericide, an amphoteric bactericide, etc. can be used. Examples of the cationic bactericide include quaternary ammonium salts such as cetylpyridinium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, lauryltrimethylammonium chloride, laurylpyridinium chloride; biguanide bactericides such as alexidine gluconate, alexidine hydrochloride, alexidine acetate, chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine gluconate, etc. Examples of the nonionic bactericide include phenolic bactericides such as isopropylmethylphenol, triclosan, hinokitiol, phenol, thymol, eugenol, bisphenol, etc. Examples of the amphoteric bactericide include dodecyldiaminoethylglycine, etc. These antibacterial components may be used alone or in combination of two or more. The blending amount of other bactericidal and antibacterial components is generally 0.001% by mass to 10% by mass based on the total mass of the oral composition.

[0022] As the surfactant, for example, sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid ester, glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, lauryl ethanolamide, sodium cocoyl sarcosinate, sodium N-lauroyl methyl taurine solution, etc. can be mentioned. The blending amount of the surfactant is generally 0.01% by mass to 10% by mass based on the total mass of the oral composition.

[0023] Examples of the abrasive include calcium carbonate, calcium phosphate, dicalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, hydrous silicic acid, anhydrous silicic acid, titanium dioxide, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, resin, and the like. The blending amount of the abrasive is generally 0.01% by mass to 50% by mass based on the total mass of the oral composition.

[0024] Examples of the thickener include cellulose derivatives such as carrageenan, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, tragacanth gum, gum arabic, synthetic thickeners such as polyvinyl alcohol, sodium polyacrylate, polyvinyl pyrrolidone, and inorganic thickeners such as silica gel, aluminum silica gel, and veegum. The blending amount of the thickener is generally 0.01% by mass to 30% by mass based on the total mass of the oral composition.

[0025] Examples of the humectant include polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3 - butylene glycol, polypropylene glycol, xylitol, maltitol, and lactitol. The blending amount of the humectant is generally 0.01% by mass to 99% by mass based on the total mass of the oral composition.

[0026] Examples of the solvent include organic solvents such as ethanol, propyl alcohol, and isopropyl alcohol, and water. The blending amount of the solvent is generally 0.01% by mass to 99% by mass based on the total mass of the oral composition.

[0027] Examples of sweeteners include, for example, palatinite, aspartame, sodium saccharin, acesulfame potassium, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, perillartine, thaumatin, aspartylphenylalanyl methyl ester, ρ-methoxycinnamic aldehyde, sucralose, xylitol, stevia, and the like. The blending amount of the sweetener is generally 0.001% by mass to 10% by mass based on the total mass of the oral composition.

[0028] Examples of flavors include, for example, compound flavors such as strawberry flavor and apple flavor, terpene-based essential oils, phenylpropanoid-based essential oils, and the like. The blending amount of the flavor is generally 0.001% by mass to 5% by mass based on the total mass of the oral composition.

[0029] Examples of cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide, ethyl 3-(p-menthane-carboxamido)acetate, N-(4-cyanomethylphenyl)-p-menthane carboxamide, and the like. The blending amount of the cooling agent is generally 0.001% by mass to 5% by mass based on the total mass of the oral composition.

[0030] Examples of pH adjusters include phosphoric acid, pantothenic acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, silicic acid, citric acid, metaphosphoric acid, polyphosphoric acid, and chemically possible salts thereof, as well as sodium hydroxide, potassium hydroxide, and the like. The blending amount of the pH adjuster is generally 0.001% by mass to 20% by mass based on the total mass of the oral composition.

[0031] Examples of preservatives include, for example, paraoxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethyl glycine hydrochloride, and the like. The blending amount of the preservative is generally 0.001% by mass to 10% by mass based on the total mass of the oral composition.

[0032] Examples of the coloring agent include dyes such as Food Blue No. 1, Food Green No. 3, Food Yellow No. 4, Food Red No. 105, and pigments such as titanium dioxide, zinc oxide, and mica. The blending amount of the coloring agent is generally 0.01% by mass to 10% by mass based on the total mass of the oral composition.

[0033] Examples of the suspending agent include fats and oils such as olive oil, camellia oil, and castor oil, and emulsions containing these fats and oils. The blending amount of the suspending agent is generally 0.001% by mass to 5% by mass based on the total mass of the oral composition.

[0034] Examples of the functional component include glycyrrhizic acid and its salts, glycyrrhetinic acid, pyridoxine hydrochloride, ε-aminocaproic acid, allantoin, sodium chloride, ascorbic acid and its salts, ascorbic acid derivatives, tocopherol acetate, zeolite, sodium fluoride, sodium monofluorophosphate, polyethylene glycol, potassium nitrate, azulene sulfonic acid and its salts, aluminum lactate, and tranexamic acid. The blending amount of the functional component is generally 0.001% by mass to 10% by mass based on the total mass of the oral composition.

[0035] Examples of the flavoring component include tea extracts, dry distillates of tea, and sodium glutamate. The blending amount of the flavoring component is generally 0.001% by mass to 5% by mass based on the total mass of the oral composition.

[0036] In addition to the above, the oral composition of the present invention may contain a crude drug extract. Examples of crude drug extracts include, for example, as examples of crude drug extracts, chamomile extract, aconite extract, jujube extract, hop extract, lavender extract, linden extract, hawthorn extract, calendula extract, kudzu extract, wolfberry extract, clove extract, denshichininjin extract, sage extract, momordica extract, balloon flower extract, licorice extract, peony extract, Japanese apricot extract, forsythia extract, tea extract, white mustard extract, large-leaf magnolia extract, white birch extract, carrot extract, asenyakku extract, turmeric extract, rosemary extract, etc. Among these, one or more of them can be used in combination.

[0037] The oral composition of the present invention can be produced according to a conventional method, and its production method is not particularly limited. In addition, the obtained oral composition can be filled into an aluminum tube, a laminated tube, a glass-evaporated tube, a plastic tube, a plastic bottle, an aerosol container, etc. and used.

[0038] As described above, the oral composition of the present invention has been described, but the present invention is not limited thereto. For example, in the oral composition of the present invention, in addition to the above-described components, components having an arbitrary function can be blended.

Examples

[0039] Next, specific examples of the present invention will be described. <Manufacture of Oral Composition> (Examples 1 to 5, Comparative Examples 1 to 4) The components shown in Table 1 were prepared to have the contents shown in Table 1, and an oral composition was produced according to a conventional method.

[0040] As the coffee seed powder, NIKKOL Cafe scrub UC (manufactured by Nikko Chemicals Co., Ltd.) was used. As the silica, SYLOPURE® 60 (manufactured by Fuji Silysia Chemical Ltd.) was used. As the coffee extract, Georgia® THE BLACK (manufactured by The Coca-Cola Bottling Company of Japan, Ltd.) was used. As the pulverized charcoal, medicinal charcoal (manufactured by Samsung Pharmaceutical Co., Ltd.) was used. In Comparative Example 4, assuming that 8 g of coffee beans were extracted with 140 mL of hot water, the amount corresponding to 0.5% by mass of the coffee seed powder (8.75% by mass) was used as the addition amount.

[0041] <Evaluation Method> [Preparation of Biofilm Model] Streptococcus mutans (Streptococcus mutans JCM5705) was pre-cultured in SCD medium (Daiichi, Fujifilm Wako Pure Chemical Corporation) at 32.5 °C for 24 hours to obtain a pre-culture broth. The obtained pre-culture broth was added to 1% sucrose-containing SCD medium so that the number of bacteria became 10 6 CFU / mL to obtain a culture broth, and the culture broth was transferred to a test tube. The test tube was tilted diagonally and anaerobically cultured at 37 °C for 20 hours to obtain a biofilm model.

[0042] [Biofilm Removal Test] The prepared biofilm model was washed twice with 0.01 mol / L phosphate buffered saline (PBS) to remove planktonic bacteria. 5 mL of the oral composition of each example and each comparative example was added to the biofilm model in the test tube and stirred with a vortex mixer for 3 minutes. Each test sample was removed, and the remaining biofilm model was washed twice with 5 mL of PBS, then stained with 1 mL of 0.1% crystal violet solution for 10 minutes. The crystal violet solution was removed, washed twice with 5 mL of PBS, then 5 mL of ethanol was added and stirred with a vortex mixer for 1 minute to extract crystal violet from the stained biofilm model. The extract was diluted 10-fold with distilled water, and the absorbance at 590 nm was measured with a microplate reader.

[0043] Here, the sample tested in the same manner using water as the test sample (Comparative Example 1) was used as a control, and the biofilm residual rate was determined from the following formula, and the biofilm removal effect was evaluated according to the following criteria. Biofilm residual rate (%) = absorbance of each test sample / absorbance of control × 100 (Evaluation criteria) A: The biofilm residual rate (%) is 25% or less. B: The biofilm residual rate (%) is higher than 25% and 30% or less. C: The biofilm residual rate (%) is higher than 30% and 60% or less. D: The biofilm residual rate (%) is higher than 60%. The above evaluation results are shown in accordance with Table 1.

[0044]

Table 1

[0045] As is clear from Table 1, it can be seen that the coffee seed grind alone shows a biofilm removal effect compared to Example 1 and Comparative Examples 1 and 2. Also, it can be seen that by combining the coffee seed grind with silica in Examples 2 to 5, the biofilm removal effect becomes remarkable. In contrast, satisfactory results were not obtained in the comparative examples.

[0046] Also, the following shows formulation examples when the oral composition of the present invention is applied to a paste dentifrice and a wet dentifrice (gel dentifrice). Among the following formulation examples, the coffee seed extract oil is, for example, NIKKOL Cafe extract oil UC (manufactured by Nikko Chemicals Co., Ltd.). <Paste dentifrice> TIFF2025089703000002.tif86169<Gel dentifrice> TIFF2025089703000003.tif85169

Claims

1. Comprising a pulverized plant seed Oral composition.

2. The pulverized plant seed is a pulverized coffee seed The oral composition according to claim 1.

3. Further comprising silica The oral composition according to claim 1.

4. The average particle size of the pulverized plant seed is 50 μm or more and 1000 μm or less The oral composition according to claim 1.

5. The average particle size of the silica is 1 μm or more and 1000 μm or less The oral composition according to claim 3.

6. The content of the pulverized plant seed is 0.01% by mass or more and 10% by mass or less The oral composition according to claim 1.

7. The content of the silica is 0.01% by mass or more and 50% by mass or less The oral composition according to claim 3.

8. It is a biofilm remover The oral composition according to claim 1.

Images