Composition for preparing liposomes

Abstract

To provide a composition that enables simple preparation of liposomes having positively charged surfaces without raising safety concerns when used in cosmetics or topical skin preparations.SOLUTION: The present invention provides a composition for preparing liposomes having positively charged surfaces, the composition containing the following components (A) and (B), with the content of component (A) being 1 to 30 mass% and the content of component (B) being 70 to 99 mass%. The inventive composition for preparing liposomes enables simple preparation of liposomes having positively charged surfaces through dispersion in water. Component (A) is a liposome membrane component containing the following components (A1) and (A2): (A1) phospholipid; and (A2) sphingosine compound. Component (B) is a polyhydric alcohol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a preparation composition for positively charged liposomes, which contains a liposome membrane component containing phospholipids and sphingolipids and a polyhydric alcohol.

Background Art

[0002] Liposomes are spherical closed vesicles (vesicles) composed of a lipid bilayer membrane formed mainly of phospholipids. An oily active ingredient can be encapsulated within the membrane, and a hydrophilic active ingredient can be encapsulated within the inner aqueous phase. Liposomes are excellent in terms of feel and moisturizing effects, and also enhance the permeability of the encapsulated active ingredient into the skin. Therefore, they have been used in cosmetics and topical skin preparations for a long time. Generally, liposomes formed from phospholipids such as lecithin have a negatively charged surface. However, in recent years, attention has been paid to the fact that the skin surface is negatively charged, and attempts have been made to positively charge the liposome surface to improve the penetration of the active ingredient into the skin by electrostatic interaction. For example, Patent Document 1 describes that liposomes with a positive zeta potential containing a cationic surfactant such as N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate are excellent in the skin permeability of the active ingredient. Cited Document 2 describes that cationic liposomes containing a cationic lipid such as 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) increase the skin absorption ability of the active ingredient. However, the compounds used to impart a positive charge to the liposome surface in these documents are components corresponding to surfactants, and there are concerns about safety to the skin such as irritation. Therefore, liposomes with a positively charged surface without such concerns are desired.

[0003] Sphingosines have various effects and functions such as moisturizing, anti-acne, anti-inflammatory, and normalization of epidermal keratinization. They are one of the active ingredients that have been used in cosmetics or topical skin agents since ancient times and are considered safe (for example, Patent Document 3). However, in the field of cosmetics or topical skin agents, there is no known attempt to use sphingosines encapsulated in liposomes. In general, the preparation of liposomes requires complicated operations, so it is desired to be able to easily prepare liposomes. Furthermore, it is also desired that raw materials that can easily prepare liposomes are available as commercial products.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0005] An object of the present invention is to provide a composition that can easily prepare positively charged liposomes that are safe for use in cosmetics or topical skin agents.

Means for Solving the Problems

[0006] As a result of intensive studies to solve the above problems, the present inventors have found that a composition for preparing positively charged liposomes containing the following components (A) and (B), wherein the content of component (A) is 1 to 30% by mass and the content of component (B) is 70 to 99% by mass, can solve the above problems, and thus completed the present invention. (A) A liposome membrane component containing the following components (A1) and (A2) (A1) Phospholipid (A2) Sphingosines (B) Polyhydric alcohol

Advantages of the Invention

[0007] The composition for preparing liposomes of the present invention can easily prepare liposomes with a positively charged surface by dispersing it in water. In addition, the liposomes prepared by the composition for preparing liposomes of the present invention have no concerns in terms of safety when used in cosmetics or external skin preparations. Since the surface is positively charged, they are excellent in the permeability of the active ingredient into the skin. Also, they are excellent in terms of usability such as ease of spreading during application, lack of stickiness during drying, and moist feeling after drying.

Embodiments for Carrying Out the Invention

[0008] The composition for preparing liposomes of the present invention contains the following components (A) and (B). (A) Liposome membrane component containing the following components (A1) and (A2) (A1) Phospholipid (A2) Sphingosines (B) Polyhydric alcohol

[0009] As the phospholipids of component (A1) used in the present invention, there are diacylglycerol lipids having polar groups such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidic acid; lecithin obtained from plants such as soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, barley and egg yolk, and hydrogenated products thereof. These may contain monoacylglycerol lipids or lysophosphatidylcholine. Furthermore, these may be derivatives modified with polyoxyalkylene groups such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, from the viewpoints of availability and more exerting the effects of the present invention, lecithin and hydrogenated products thereof are preferably mentioned. As lecithin, those having different contents of phosphatidylcholine (hereinafter referred to as PC) depending on the degree of purification are commercially available, but from the viewpoints of the dispersion stability of liposomes described later and more exerting the effects of the present invention, those having a PC content of 60% by mass or more, preferably 70% by mass or more, more preferably 90% by mass or more are used.

[0010] In the present invention, component (A1) is used as the main component forming the liposome membrane. Component (A1) of the present invention is preferably contained in component (A) at 40% by mass or more, preferably 50% by mass or more, more preferably 60% by mass or more. If the content of component (A1) of the present invention is less than this, liposomes may not be sufficiently formed.

[0011] As the sphingosines of component (A2) used in the present invention, there are sphingosine, dihydrosphingosine, phytosphingosine, sphingadienine, and N-methylated or N,N-dimethylated forms thereof. These may be used alone or in combination of two or more. Among these, from the viewpoint of more exerting the effects of the present invention, sphingosine, dihydrosphingosine, phytosphingosine are preferably mentioned, and phytosphingosine is most preferred.

[0012] In the present invention, component (A2) is used as a liposome membrane component for the purpose of positively charging the liposome surface. Further, component (A2) also acts as an active ingredient for the skin. In the present invention, component (A2) may be blended within the range in which liposomes with a positively charged surface are formed, and there is no particular limitation on the blending amount thereof, but the specific blending amount will be described below. Here, the surface of liposomes formed by lecithin is generally negatively charged, and since PC is a neutral phospholipid, the negative charge of liposomes formed by lecithin is due to acidic phospholipids other than PC contained in lecithin. Therefore, when lecithin is used as component (A1) of the present invention, the blending amount of component (A2) required to positively charge the liposome surface varies depending on the PC content of the lecithin used.

[0013] When lecithin with a PC content of 90% by mass or more is used as component (A1), component (A2) may be blended in an amount of 0.2 parts by mass or more, preferably 0.5 parts by mass or more, more preferably 1 part by mass or more, per 100 parts by mass of component (A1). When lecithin with a PC content of 80 - 90% by mass is used as component (A1), component (A2) may be blended in an amount of 1 part by mass or more, preferably 2 parts by mass or more, more preferably 3 parts by mass or more, per 100 parts by mass of component (A1). When lecithin with a PC content of 70 - 80% by mass is used as component (A1), component (A2) may be blended in an amount of 3 parts by mass or more, preferably 5 parts by mass or more, more preferably 7 parts by mass or more, per 100 parts by mass of component (A1). When lecithin with a PC content of 60 - 70% by mass is used as component (A1), component (A2) may be blended in an amount of 7 parts by mass or more, preferably 10 parts by mass or more, more preferably 15 parts by mass or more, per 100 parts by mass of component (A1). By setting the blending ratio of component (A2) to component (A1) as described above, liposomes with a positively charged surface can be obtained.

[0014] On the other hand, regarding the upper limit of the blending amount of component (A2) in the present invention, there is no particular limitation. However, regardless of the PC content of the lecithin used, component (A2) is preferably 40 parts by mass or less, more preferably 35 parts by mass or less, and most preferably 30 parts by mass or less with respect to 100 parts by mass of component (A1). When the blending amount of component (A2) is more than this, component (A2) may not be retained in the liposome membrane and may precipitate over time.

[0015] As described above, in the present invention, in order to obtain positively charged liposomes, the lower the PC content of the lecithin, the more necessary it is to increase the blending amount of component (A2). Even when lecithin with a PC content of less than 60% by mass is used as component (A1), positively charged liposomes can be obtained by further increasing the blending amount of component (A2). However, as the PC content of the lecithin used as component (A1) decreases, the dispersion stability of the liposomes tends to decrease. Therefore, as the lecithin, it is preferable to use one with a PC content of 60% by mass or more, more preferably 70% by mass or more, and most preferably 90% by mass or more.

[0016] The liposome membrane component of component (A) of the present invention can further contain component (A3) sterols for the purpose of improving the dispersion stability of the liposomes. Specific examples of sterols include animal-derived sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, and desmosterol; plant-derived sterols such as stigmasterol, sitosterol, campesterol, brassicasterol, and phytosterol which is a mixture of these; microbial-derived sterols such as ergosterol; γ-oryzanol; and esterified products thereof. These sterols may be used alone or in combination of two or more. Among these, from the viewpoint of fully exerting the effects of the present invention, cholesterol, phytosterol, and γ-oryzanol are preferably mentioned. Component (A3) of the present invention is preferably contained in component (A) in an amount of 1 to 39% by mass, more preferably 2 to 35% by mass, and still more preferably 3 to 30% by mass.

[0017] Examples of the polyhydric alcohol as the component (B) used in the present invention include dihydric alcohols such as ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol; trihydric alcohols such as glycerin, trimethylolpropane, 1,2,6-hexanetriol; sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, mannitol; glyceryl ethers such as ethyl glycerin, butyl glycerin, hexyl glycerin, ethylhexyl glycerin, cyclohexyl glycerin; polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin, isosorbide and its derivatives. These may be used alone or in combination of two or more. Among these, glycerin, diglycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol are preferably mentioned.

[0018] The composition for preparing liposomes of the present invention contains the liposome membrane component of the component (A) and the polyhydric alcohol of the component (B). In the present invention, the component (B) is used for the purpose of dissolving or dispersing the component (A) to facilitate the dispersion of the component (A) in water. From the viewpoint of sufficiently dissolving or dispersing the component (A) in the component (B), the content of the component (B) in the composition for preparing liposomes of the present invention may be 70 to 99% by mass, preferably 75 to 99% by mass, and the content of the component (A) is 1 to 30% by mass, preferably 1 to 25% by mass.

[0019] When the composition for preparing liposomes of the present invention is commercially available as a raw material for preparing liposomes, it will be stored for a long period of time during the distribution process. Therefore, it is important to have excellent long-term storage stability. From such a viewpoint, it is preferable that the composition for preparing liposomes of the present invention further contains an organic acid as component (C). By containing component (C), the precipitation of highly crystalline component (A2) sphingosines over time can be suppressed, and the storage stability of the composition for preparing liposomes of the present invention can be improved. It is presumed that component (C) suppresses the precipitation of component (A2) over time because component (C) protects the amino group of component (A2), thereby reducing its crystallinity.

[0020] Examples of the organic acid of component (C) used in the present invention include acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, benzoic acid, salicylic acid, gallic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, phthalic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, levulinic acid, ketoglutaric acid, glutamic acid, aspartic acid, phytic acid, etc. These may be used alone or in combination of two or more. Among these, benzoic acid, succinic acid, lactic acid, malic acid, citric acid, glutamic acid, aspartic acid, phytic acid are preferable, and lactic acid, malic acid, citric acid are more preferable.

[0021] Regarding the blending amount of component (C) in the composition for preparing liposomes of the present invention, from the viewpoint of further improving the storage stability, it is preferable that component (C) is 0.5 mol or more, preferably 0.6 mol or more, more preferably 0.7 mol or more, based on 1 mol of component (A2). On the other hand, although there is no particular limitation on the upper limit of the blending amount of component (C), it is preferable that component (C) is 10 mol or less, preferably 5 mol or less, more preferably 3 mol or less, based on 1 mol of component (A2).

[0022] The method for producing the composition for preparing liposomes of the present invention is not particularly limited, and it is produced by stirring and mixing each component formulated in the composition for preparing liposomes of the present invention while heating.

[0023] The composition for preparing liposomes of the present invention obtained as described above can obtain positively charged liposomes by performing a simple operation of dispersing it in water. When dispersing the composition for preparing liposomes of the present invention in water, if the composition for preparing liposomes of the present invention is in a solid state at room temperature, it is preferable to preheat and melt the composition for preparing liposomes of the present invention. Further, the composition for preparing liposomes of the present invention may be further diluted with a polyhydric alcohol or ethanol to form a polyhydric alcohol solution, and such a polyhydric alcohol solution may be dispersed in water. As the polyhydric alcohol used for dilution, those exemplified as component (B) above can be used.

[0024] There is no particular limitation on the stirring method when dispersing the composition for preparing liposomes of the present invention in water, and it is advisable to disperse it using a commonly used stirring device. Further, the obtained liposomes may be sized by high-pressure treatment using a microfluidizer or the like or sizing by an extruder.

[0025] The liposomes prepared by the composition for preparing liposomes of the present invention have excellent permeability of the active ingredient to the skin due to the positively charged surface. Therefore, the liposomes prepared by the composition for preparing liposomes of the present invention may contain active ingredients other than the essential components of the present invention as long as the effects of the present invention are not impaired. Further, as described above, component (A2) of the present invention not only positively charges the liposome surface but also acts as an active ingredient. Therefore, the liposomes prepared by the composition for preparing liposomes of the present invention have enhanced permeability of component (A2) to the skin. Also, since it is known that hair is negatively charged on its surface, the liposomes prepared by the composition for preparing liposomes of the present invention are considered to have excellent permeability of the active ingredient to hair.

[0026] As an active ingredient that can be incorporated into liposomes prepared by the composition for preparing liposomes of the present invention, it may be any lipophilic or hydrophilic active ingredient. Examples of lipophilic active ingredients include ceramides such as ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7; carotenoids such as carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, astaxanthin, crocetin, fucoxanthin; tocopherols such as α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocopherol acetate, tocopherol nicotinate; retinols such as retinol, retinol acetate, retinol palmitate, retinoic acid, retinoyl tocopheryl, retinal; lipoic acid, coenzyme Q10, ferulic acid, ursolic acid, glycyrrhetinic acid, sterol fatty acid ester, higher fatty acid, higher alcohol, various vegetable oils, and the like.Examples of hydrophilic active ingredients include hydroquinone glycosides such as β-arbutin and α-arbutin and their esters; ascorbic acid phosphate ester salts such as ascorbic acid, sodium ascorbic acid phosphate ester salt, and magnesium ascorbic acid phosphate ester salt; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, cetyl tranexamic acid, and tranexamic acid amide; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, and apple polyphenol; nicotinamide, kojic acid, 4-methoxysalicylic acid, placenta extract, glutathione, hyaluronic acid, and various plant extracts.

[0027] As a method for incorporating an active ingredient into the liposomes prepared by the composition for preparing liposomes of the present invention, when the active ingredient is oil-soluble, the oil-soluble active ingredient may be added to the composition for preparing liposomes of the present invention or a polyhydric alcohol solution obtained by diluting the composition for preparing liposomes with a polyhydric alcohol, and then dispersed in water. When the active ingredient is water-soluble, the composition for preparing liposomes of the present invention or a polyhydric alcohol solution obtained by diluting the composition for preparing liposomes with a polyhydric alcohol may be added to water in which the water-soluble active ingredient has been previously dissolved, and dispersed.

[0028] The liposomes prepared by the composition for preparing liposomes of the present invention are excellent in usability when applied to the skin. Generally, liposomes are known to be excellent in usability. Surprisingly, the liposomes prepared by the composition for preparing liposomes of the present invention are superior in usability such as ease of spreading during application, lack of stickiness during drying, and moist feeling after drying, compared to liposomes that do not contain component (A2) of the present invention.

[0029] The liposomes prepared by the composition for preparing liposomes of the present invention are obtained in a form dispersed in water (liposome solution). The liposome solution prepared by the composition for preparing liposomes of the present invention can be used as it is as a cosmetic or an external preparation for skin, or can be used by being blended during the production of a cosmetic or an external preparation for skin as a raw material.

[0030] In the present invention, that the surface is positively charged means that when measuring the zeta potential of the liposome solution by the electrophoretic light scattering measurement method, the measured value is positive (plus). Generally, the larger the absolute value of the zeta potential, the greater the electrostatic repulsive force between particles, so the dispersion stability of particles in water is improved. From such a viewpoint, the zeta potential of the liposomes of the present invention is preferably 5 mV or more, more preferably 10 mV or more, still more preferably 15 mV or more at 25°C.

[0031] The pH of the liposome solution prepared by the composition for preparing liposomes of the present invention is preferably 3 or more, more preferably 3.5 or more, still more preferably 4 or more at 25°C. When the pH is lower than this, it is not preferable from the viewpoint of irritation to the skin. On the other hand, the pH of the liposome solution is preferably 9 or less, more preferably 8.5 or less, still more preferably 8 or less at 25°C. When the pH is higher than this, the liposome surface may not be sufficiently positively charged.

[0032] In the present invention, for the preparation of the pH of the liposome solution, pH adjusters generally used in cosmetics or external skin preparations can be used. Specifically, as acidic components, inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid; organic acids such as acetic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, glutamic acid, aspartic acid, and phytic acid can be mentioned. Among these, succinic acid, lactic acid, malic acid, and citric acid are preferred, and lactic acid is most preferred. Also, as basic components, inorganic bases such as potassium hydroxide, sodium hydroxide, potassium carbonate, and sodium carbonate, and organic bases such as ammonium, monoethanolamine, diethanolamine, triethanolamine, aminomethylpropanol, aminomethylpropanediol, aminoethylpropanediol, tris(hydroxymethyl)aminoethane, lysine, and arginine can be mentioned. Among these, potassium hydroxide, sodium hydroxide, potassium carbonate, sodium carbonate, triethanolamine, and arginine are preferred, and potassium hydroxide and sodium hydroxide are most preferred.

[0033] For the liposome solution prepared by the composition for preparing liposomes of the present invention, or for cosmetics or external skin preparations, a thickening agent can be blended for the purpose of improving the dispersion stability of liposomes or imparting a desired feeling of use. In view of the fact that the surface of the liposomes of the present invention is positively charged, it is preferable to use a nonionic polymer or a cationic polymer as the thickening agent that can be used in the present invention. Specific examples of the nonionic polymer that can be used in the present invention include hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, stearoxyhydroxypropylmethylcellulose, pullulan, roasted bean gum, guar gum, tamarind seed gum, glucomannan, N-acetylglucosamine, collagen, polyvinylpyrrolidone, polyvinylpyrrolidone / vinyl acetate copolymer, polyvinyl alcohol, polyacrylamide, (PEG-240 / decyltetradeceth-20 / HDI) copolymer, and the like.Specific examples of the cationic polymer include chitosan, cationized cellulose, cationized guar gum, cationized xanthan gum, cationized starch, cationized fenugreek gum, cationized tara gum, cationized locust bean gum, diallyldimethylammonium chloride polymer, diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-diallyldimethylammonium chloride copolymer, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-methacryloyloxyethyltrimethylammonium chloride copolymer, acrylamide-methacryloyloxyethyltrimethylammonium chloride copolymer, acrylamide-acryloyloxyethyltrimethylammonium chloride copolymer, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymer, acrylamide-acrylic acid-methacrylamidopropyltrimethylammonium chloride copolymer, vinylpyrrolidone-methacrylamidopropyltrimethylammonium chloride copolymer, methacrylamidopropylammonium chloride-dimethyldiallylammonium chloride-acrylamide copolymer, vinylpyrrolidone-dimethylaminoethyl methacrylate copolymer diethyl sulfate, cationic methacryloyloxyethyl phosphorylcholine copolymer, and other (meth)acrylic acid derivatives.

[0034] On the other hand, considering that the surface of the liposome of the present invention is positively charged, using an anionic polymer as a thickener is generally considered unfavorable because it may cause aggregation and precipitation of the liposome of the present invention. However, although the transparency of the appearance decreases, there are anionic polymers that do not cause aggregation and precipitation and can be used as thickeners. Specific examples of the anionic polymer that can be used as a thickener include (co)polymers containing (meth)acrylic acid or / and (meth)acryloyldimethyltaurine as monomer units, such as carboxyvinyl polymer, (acrylates / alkyl acrylate (C10-30)) cross-polymer, (acrylic acid / lauryl methacrylate / isodecyl methacrylate) cross-polymer, (sodium acrylate / sodium acryloyldimethyltaurine) copolymer, (ammonium acryloyldimethyltaurine / VP) copolymer, (acrylamide / sodium acryloyldimethyltaurine) cross-polymer; phosphorylated cellulose nanofibers, propylene glycol alginate, hyaluronic acid, and the like. In addition, anionic polymers such as xanthan gum, gellan gum, agar, silkworm polysaccharide, and carboxymethylated cellulose nanofibers cause aggregation and precipitation of the liposome of the present invention. However, even an anionic polymer that causes such aggregation and precipitation can be formulated without causing aggregation and precipitation by adding it after adding an anionic polymer that does not cause the above-mentioned aggregation and precipitation.

[0035] The cosmetics or external skin preparations containing the composition for preparing liposomes may contain, if necessary, water and additive components usually formulated in cosmetics, such as oily bases, humectants / smoothing agents, surfactants, polymers / thickeners / gelling agents, antioxidants, reducing agents, oxidizing agents, anti-oxidants, skin-whitening agents, vitamins and their derivatives, extracts of plants / animals / microorganisms, ultraviolet absorbers, antibacterial / antiseptic agents, chelating agents, pH adjusters / acids / alkalis, solvents / propellants, antipruritics, keratolytic / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory agents, hair growth agents / blood circulation promoters / irritants, hormones, anti-wrinkle / anti-aging agents, irritation relievers, cooling agents, warming agents, powders, pigments / colorants / dyes / pigments, fragrances, etc., as long as the effects of the present invention are not impaired.

[0036] As the oily base, higher alcohols such as cetyl alcohol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerachyl alcohol, batyl alcohol, hexyl decanol, isostearyl alcohol, 2-octyldodecanol, dimer diol, etc.; aralkyl alcohols such as benzyl alcohol and derivatives; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisoheneicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acid, hydrogenated dimer acid, etc. and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. of metal soaps, and nitrogen-containing derivatives such as amides; hydrocarbons such as liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, etc.; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer, etc.; vegetable oils and fats such as coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats and oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale oil, lanolin, orange raffia oil, etc.;Lanolin such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetate (cetyl·lanolyl) ester; Sphingophospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phospholipids such as phosphatidic acid, cyclic lysophosphatidic acid or its salts, lysophosphatidylcholine; Phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; Sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; Saponins; Saponins; Acyl sarcosine alkyl esters such as cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosterol macadamia nut oil fatty acid, phytosterol sunflower seed oil fatty acid, phytosterol isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long-chain branched fatty acid, cholesteryl long-chain α-hydroxy fatty acid, etc.; Lipid complexes such as phospholipid-cholesterol complex, phospholipid-phytosterol complex;Octyldodecyl myristate, hexyl decyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyl decyl dimethyl octanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate and other monoalcohol carboxylic acid esters; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-ela lactone, diisostearyl malate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri(caprylic acid / capric acid), glyceryl tri(caprylic acid / capric acid / myristic acid / stearic acid), hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosanedioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic acid / sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearic acid / stearic acid / rosinic acid), diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic acid / isostearic acid / ricinoleic acid), diglyceryl oligoster ester (hexyl decanoic acid / sebacic acid), ethylene glycol distearate (distearic acid ethylene glycol), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate and other polyhydric alcohol fatty acid esters; alkyl ethers such as dicaprylyl ether; derivatives of dimer acid or dimer diol such as diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, diisostearyl dimer dilinoleate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil dimer dilinoleate, hydroxyalkyl dimer dilinoleyl ether, etc.Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); silicones such as dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethylsilicone, phenyldimethylsilicone, (aminoethylaminopropylmethylsilicone / dimethylsilicone) copolymer, dimethiconol, dimethiconol cross polymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyldimethylsilicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amidalkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, polysiloxane-oxyalkylene copolymer; fluorine-based oils such as perfluorodecane, perfluorooctane, perfluoropolyether are preferably mentioned.;

[0037] As the humectant and feel improver, there are polyols such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, erythritol and their polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; sugars and their derivatives such as glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, glucosyltrehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated, hydroxyalkylated cyclodextrin), β-glucan, chitin, chitosan, heparin and its derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; extracts of Sirococcus clavigignenti-juglandacearum, polysaccharides of Sirococcus clavigignenti-juglandacearum; fructans such as inulin, levan; fucoidan; tuberose polysaccharide, natural-derived polysaccharides; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its salts such as sodium salt;Amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and their salts; Protein peptides and their derivatives such as collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptides, keratin-degrading peptides, hydrolyzed keratin, conchiolin-degrading peptides, hydrolyzed conchiolin, silk protein-degrading peptides, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean protein-degrading peptides, wheat protein-degrading peptides, hydrolyzed wheat protein, casein-degrading peptides, acylated peptides; Acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; Silylated peptides; Lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; Choline chloride, phosphorylcholine; Animal and plant extract components such as placenta extract, aeroelastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rosa multiflora extract, digitalis extract, eucalyptus extract, melilot extract, etc., ceramides such as natural ceramides (type 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and extracts containing glycosphingolipids are preferably mentioned.;

[0038] As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, etc. are preferably exemplified. There is no particular limitation on the HLB of the surfactant, and those with as low as about 1 to as high as about 20 can be used, and it is also preferable to combine those with low HLB and high HLB. Examples of preferred surfactants include, among anionic surfactants, fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfate salts such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alaninate, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methyl alaninate; acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, triethanolamine cocoyl alaninate, and lysine Na dilauroyl glutamate; polyoxyethylene alkyl ether acetate salts such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylate salts; acyl lactate salts; polyoxyethylene fatty amine sulfate salts; fatty acid alkanolamide sulfate salts; fatty acid glyceride sulfate salts such as sodium hydrogenated palm oil fatty acid glycerol sulfate; polyoxyethylene alkylbenzene sulfate salts; olefin sulfonate salts such as sodium α-olefin sulfonate; alkyl sulfosuccinate salts such as disodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate;Alkyl ether sulfosuccinates such as sodium lauryl sulfosuccinate, sodium monolauroyl monoethanolamine polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfacetates; alkyl ether phosphate ester salts such as sodium lauryl phosphate, disodium lauryl phosphate, trisodium lauryl phosphate, and sodium monooleyl phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or its salts; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; etc.; In the case of nonionic surfactants, various polyoxyethylene adduct numbers of polyoxyethylene alkyl ethers such as laureths (polyoxyethylene lauryl ethers), cetes (polyoxyethylene cetyl ethers), stearates (polyoxyethylene stearyl ethers), behenes (polyoxyethylene behenyl ether), isostearates (polyoxyethylene isostearyl ether), octyldeces (polyoxyethylene octyldodecyl ether); polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid and other castor oil and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin monoricinoleate, glycerin monoerucate, glyceryl sesquioleate, glyceryl α,α'-oleoyl pyroglutamate, glyceryl monostearate malate; polyglyceryl fatty acid esters such as polyglyceryl-2 stearate, polyglyceryl-3 stearate, polyglyceryl-4 stearate, polyglyceryl-5 stearate, polyglyceryl-6 stearate, polyglyceryl-8 stearate, polyglyceryl-10 stearate, polyglyceryl-6 distearate, polyglyceryl-10 distearate, polyglyceryl-2 tristearate, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, polyglyceryl-3 isostearate, polyglyceryl-4 isostearate, polyglyceryl-5 isostearate, polyglyceryl-6 isostearate, polyglyceryl-8 isostearate, polyglyceryl-10 isostearate, polyglyceryl-2 diisostearate (diglyceryl diisostearate), polyglyceryl-3 diisostearate, polyglyceryl-10 diisostearate, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, polyglyceryl-3 oleate, polyglyceryl-4 oleate, polyglyceryl-5 oleate, polyglyceryl-6 oleate, polyglyceryl-8 oleate, polyglyceryl-10 oleate, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, diglycerol sorbitan tetra-2-ethylhexanoate; sucrose fatty acid esters such as sucrose laurate, sucrose myristate, sucrose palmitate, sucrose dilaurate, sucrose dimyristate, sucrose dipalmitate, sugar derivative partial esters such as methyl glucoside fatty acid ester, trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosylerythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene-propylene glycol fatty acid ester; polyoxyethylene glycerol fatty acid esters such as polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester; polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol; polyhydric alcohol alkyl ethers;Polyoxyethylene alkylamine; Tetrapolyoxyethylene·tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponin, surfactin, rhamnolipid, sophorolipid; Polyoxyethylene fatty acid amide; Fatty acid alkanolamides such as coconut fatty acid monoethanolamide (cocamide MEA), coconut fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (paltamide MEA), palmitic acid diethanolamide (paltamide DEA), coconut fatty acid methylethanolamide (cocamide methyl MEA); Alkyl dimethylamine oxides such as lauramine oxide, cocoamine oxide, stearamine oxide, behenamine oxide; Alkyl ethoxydimethylamine oxide; Polyoxyethylene alkyl mercaptan; Silicone-based nonionic surfactants such as polyether-modified silicone like dimethicone copolyol, polysiloxane·oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc.; For cationic surfactants, alkyl trimethyl ammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; Alkyl trimethyl ammonium bromides such as stearyltrimonium bromide; Dialkyl dimethyl ammonium chlorides such as distearyldimonium chloride, dicocodimonium chloride; Fatty acid amide amines and their salts such as stearamide propyldimethylamine, stearamide ethyldiethylamine; Alkyl ether amines and their salts or quaternary salts such as stearoxypropyldimethylamine; Fatty acid amide type quaternary ammonium salts such as long-chain branched fatty acid (12 - 31) aminopropyl ethyldimethylammonium ethyl sulfate, lanolin fatty acid aminopropyl ethyldimethylammonium ethyl sulfate; Polyoxyethylene alkylamine and its salts or quaternary salts; Alkylamine salts; Fatty acid amide guanidinium salts; Alkyl ether amine monium salts; Alkyl trialkylene glycol ammonium salts; Benzalkonium salts;Benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyldimethylsilicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, etc., silicone-based cationic surfactants; for amphoteric surfactants, N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocoamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate ester; phosphate-type betaines such as alkyldimethylaminoethanol phosphate ester; sphingolipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysophosphatidylcholine, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated phospholipids, etc.; silicone-based amphoteric surfactants; for polymer surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid·methacrylic acid alkyl copolymers; various silicone-based surfactants are preferably mentioned.

[0039] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, carob seed, carrageenan, galactan, gum arabic, tara gum, tamarind, farselan, karaya gum, sida acuta, carrageenan, tragacanth gum, pectin, pectic acid and salts such as sodium salts, alginic acid and salts such as sodium salts, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts such as its sodium salt, methylhydroxypropylcellulose, carboxylated cellulose nanofiber, carboxymethylated cellulose nanofiber, phosphoric acid esterified cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfate cellulose, crystalline cellulose, cellulose powder and other celluloses and their derivatives; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch and other starch-based polymers, starch derivatives such as hydroxypropyltrimonium chloride starch, octenyl succinic acid corn starch aluminum; alginic acid derivatives such as sodium alginate, propylene glycol alginate; polyvinyl pyridone (PVP), polyvinyl alcohol (PVA), vinyl pyridone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylic acid ester copolymers such as (methacryloyloxyethyl carboxy betaine / methacrylic acid alkyl) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethyl silicone / vinyl dimethyl silicone) cross-polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP;Partially saponified polyvinyl acetate, maleic acid copolymer; vinyl pyrrolidone - dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water - dispersible polyester; polyacrylamide; polyacrylate esters copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salts such as sodium salt, acrylic acid - methacrylic acid ester copolymer; acrylic acid - methacrylic acid alkyl copolymer; cationized cellulose such as polyquaternium - 10, diallyldimethylammonium chloride - acrylamide copolymer such as polyquaternium - 7, acrylic acid - diallyldimethylammonium chloride copolymer such as polyquaternium - 22, acrylic acid - diallyldimethylammonium chloride - acrylamide copolymer such as polyquaternium - 39, acrylic acid - cationized methacrylic acid ester copolymer, acrylic acid - cationized methacrylamide copolymer, acrylic acid - methyl acrylate - methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium - 47, methacrylic acid choline ester polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharides such as guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polymer of 2 - methacryloyloxyethyl phosphorylcholine such as polyquaternium - 51 and copolymer with butyl methacrylate etc.; acrylic resin emulsion, polyethyl acrylate emulsion, polyalkyl acrylate emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone - based copolymers such as acrylic - silicone graft copolymer; various fluorine - based polymers; 12 - hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristate;Anhydrous silicic acid, fumed silica (ultrafine anhydrous silicic acid), magnesium aluminum silicate, magnesium sodium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid ester, fructooligosaccharide fatty acid ester are preferably mentioned.;

[0040] Examples of the antioxidant include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride. Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Examples of the oxidizing agent include hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like. Examples of the antioxidant include ascorbic acid phosphate ester salts such as ascorbic acid, sodium ascorbic acid phosphate ester and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and its fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanidin, catechin, ellagic acid, quercetin, apple polyphenol; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, proanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, platinum nanocolloid and the like.

[0041] As whitening agents, hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid phosphate esters such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, cetyl tranexamate, tranexamic acid amide; licorice extract-related substances such as glabridin, glabrene, liquiritin, isoliquiritin; plant extracts such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, tamarix chinensis extract, saxifraga stolonifera extract are preferably mentioned.

[0042] Examples of vitamins and their derivatives include vitamin A compounds such as retinol, retinol acetate, and retinol palmitate; vitamin B group compounds such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acid compounds such as nicotinamide and benzyl nicotinate, and choline compounds; vitamin C compounds such as ascorbic acid and its salts such as sodium ascorbate; vitamin D; vitamin E compounds such as α, β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, stearyl ascorbate, palmitoyl ascorbate, and dipalmitoyl ascorbate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as ascorbyl phosphate tocopherol; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate ester, tocotrienol, and other various vitamin derivatives are preferably mentioned.

[0043] Examples of plant, animal, and microbial extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, hollyhock extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, ginseng extract, wikstroemia extract, turmeric extract, oolong tea extract, Japanese lacquer extract, euryale extract, etinasia leaf extract, polygonatum extract, gold extract, cork tree bark extract, Chinese magnoliavine fruit extract, barley extract, carrot extract, carrot extract, mugwort extract, rye extract, calcarea extract, licorice extract, oil-soluble licorice extract, kiwi extract, Chinese quince extract, shiitake mushroom extract, cinchona extract, cucumber extract, chestnut leaf extract, guanosine, guava extract, kudzu root extract, gardenia extract, kumasasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, black sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentiana extract, phellodendron extract, black tea extract, yeast extract, camphor tree extract, coffee extract, burdock extract, rice extract, fermented rice extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, loquat extract, saikosaponin extract, psycotria extract, saikosaponin extract, saffron extract, sage extract, soapwort extract, sasakawa extract, Japanese quince extract, mountain ash extract, Japanese pepper extract, shiitake mushroom extract, angelica extract, scutellaria extract, perilla extract, cinnamon tree extract, shimotsuke extract, jatoba extract, peony extract, ginger extract, Japanese butterbur root extract, silver birch extract, white shiitake mushroom extract, Japanese pampas grass extract, stevia extract, fermented stevia, tamarix chinensis extract, common St. John's wort extract, European mountain ash extract, European ivy extract, European mint extract, European sage extract, zinnia extract, centaury extract, centella extract, sophora extract, angelica dahurica extract,Extracts such as soybean extract, spinach extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaia extract, chinpi extract, tea tree oil, sweet tea extract, capsicum extract, toki extract, toki nsenka extract, tou'nin extract, tohii extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, rosa multiflora extract, hibiscus extract, buckmoundou extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, pariateria extract, hikiokoshi extract, bisabolol, hinoki extract, bifidobacterium extract, loquat extract, fuki dandelion extract, fuki notou extract, bukuryou extract, butcher's bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, mykaika extract, pine extract, maple extract, mizubashou extract, mukuroji extract, melissa extract, mozuku extract, peach extract, yaguruma giku extract, eucalyptus extract, snowdrop extract, yuzu extract, lily extract, yokuin nin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, raisin extract, lettuce extract, lemon extract, rengyou extract, renge sou extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, waremokou extract, etc. are preferably listed as such.

[0044] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, monoglycerin ester of para-aminobenzoic acid, ethyl N,N-dipropoxy para-aminobenzoate, ethyl N,N-diethoxy para-aminobenzoate, ethyl N,N-dimethyl para-aminobenzoate, butyl N,N-dimethyl para-aminobenzoate, ethyl N,N-dimethyl para-aminobenzoate; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate and other salicylic acid-based ultraviolet absorbers; cinnamic acid-based ultraviolet absorbers such as octyl cinnamate, ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxy cinnamate, isopropyl p-methoxy cinnamate, isoamyl p-methoxy cinnamate, 2-ethylhexyl p-methoxy cinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (sinoxate), cyclohexyl-p-methoxy cinnamate, ethyl α-cyano-β-phenyl cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrylene), glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, hydantoin derivatives such as 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, phenylbenzimidazolesulfonic acid, terephthalylidene dicamphorsulfonic acid, droxmetrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferably mentioned.;

[0045] Examples of antibacterial and preservative agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; lanolin fatty acid and its salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions are preferably mentioned. However, when used as an antibacterial or preservative agent for the purpose of preservation, from the perspective of the safety of cosmetics or topical skin preparations, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether.

[0046] Chelating agents include, preferably, edetates such as EDTA, EDTA2Na, EDTA3Na, EDTA4Na (ethylenediaminetetraacetate); hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid.

[0047] pH adjusters, acids and alkalis include, preferably, citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, ammonium carbonate.

[0048] As solvents and propellants, lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyldiol; glycol ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; propellants such as LPG, dimethyl ether, and carbon dioxide gas are preferably mentioned.

[0049] Examples of antipruritics include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors, etc. Examples of keratolytic and resolvent agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, glycolic acid, etc. Examples of antiperspirants include hydroxyaluminum chloride, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, etc. Examples of cooling agents include menthol, methyl salicylate, etc. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, caffeine, etc. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, etc. Preferred examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

[0050] As anti-inflammatory agents, glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphenhydramine hydrochloride, chlorpheniramine maleate; plant extracts such as peach leaf extract and mugwort leaf extract are preferably mentioned. As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as centella asiatica extract, capsicum tincture, ginger tincture, ginger extract, cantharis tincture; capsaicin, nonivamide, zingerone, ichthyol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, celeferin, γ-oryzanol, celeferin, derivatives such as vitamin E and tocopheryl nicotinate · tocopheryl acetate, γ-oryzanol, nicotinic acid and derivatives such as nicotinamide · benzyl nicotinate · inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, monoglyceride pentadecanoate, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, minoxidil are preferably mentioned. As hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, etc. are preferably mentioned.

[0051] Examples of anti-wrinkle and anti-aging agents include ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbic acid phosphate ester, and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanidin, pantothenic acid, panthenol, soy saponin, lovastatin, isoflavone, coenzyme Q10, chondroitin sulfate, N-acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolyzate, adenosine 5'-phosphate, phosphatidylinositol, isopropyl oxopropylamino carbonyl pyrrolidine carbonyl methyl propylamino carbonyl benzoyl amino acetic acid Na, tranexamic acid and its derivatives, etc. are preferably mentioned.

[0052] Preferred examples of the irritation reliever include mannosylerythritol lipid, diethylene glycol oligomer diester of dimer linoleic acid, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amide amine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, polypropylene glycol and the like. Preferred examples of the cooling agent include menthol, camphor, menthyl lactate, monomethyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, perilla oil and derivatives thereof. Preferred examples of the warming agent include vanillin and its derivatives, vanillyl amide of nonanoic acid, gingerol, zingerone, capsicum tincture, capsicum extract, benzyl nicotinate, methyl nicotinate, phenyl nicotinate, tocopherol nicotinate and other nicotinic acid derivatives, capsaicin, Dutch pepper extract, Japanese pepper extract, ginger extract, cantharides extract and the like.

[0053] Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstates, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, navy blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder, gold, aluminum, and other inorganic powders of various sizes and shapes, and inorganic powders such as those obtained by treating these with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents to render them hydrophobic or hydrophilic; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, laminated powder of polyethylene terephthalate and polymethyl methacrylate, laminated powder of polyethylene terephthalate, aluminum, and epoxy, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders, surface-treated powders, and organic-inorganic composite powders of various sizes and shapes are preferably mentioned.Examples of inorganic salts include sodium chloride-containing salts such as table salt, refined salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as monosodium phosphate, disodium phosphate, trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates are preferably mentioned.

[0054] Examples of pigments, colorants, dyes, and pigments include Pigment Brown 201, Pigment Black 401, Pigment Violet 201, Pigment Violet 401, Acid Blue 1, Acid Blue 2, Pigment Blue 201, Pigment Blue 202, Pigment Blue 203, Pigment Blue 204, Pigment Blue 205, Pigment Blue 403, Pigment Blue 404, Pigment Green 3, Pigment Green 201, Pigment Green 202, Pigment Green 204, Pigment Green 205, Pigment Green 3, Pigment Green 401, Pigment Green 402, Pigment Red 102, Pigment Red 104-1, Pigment Red 105-1, Pigment Red 106, Pigment Red 2, Pigment Red 3, Pigment Red 201, Pigment Red 202, Pigment Red 203, Pigment Red 204, Pigment Red 205, Pigment Red 206, Pigment Red 207, Pigment Red 208, Pigment Red 213, Pigment Red 214, Pigment Red 215, Pigment Red 218, Pigment Red 219, Pigment Red 220, Pigment Red 221, Pigment Red 223, Pigment Red 225, Pigment Red 226, Pigment Red 227, Pigment Red 228, Pigment Red 230-1, Pigment Red 230-2, Pigment Red 231, Pigment Red 232, Pigment Red 3, Pigment Red 401, Pigment Red 404, Pigment Red 405, Pigment Red 501, Pigment Red 502, Pigment Red 503, Pigment Red 504, Pigment Red 505, Pigment Red 506, Pigment Orange 201, Pigment Orange 203, Pigment Orange 204, Pigment Orange 205, Pigment Orange 206, Pigment Orange 207, Pigment Orange 401, Pigment Orange 402, Pigment Orange 403, Pigment Yellow 201, Pigment Yellow 202-1, Pigment Yellow 202-2, Pigment Yellow 203, Pigment Yellow 204, Pigment Yellow 205, Pigment Yellow 4, Pigment Yellow 401, Pigment Yellow 402, Pigment Yellow 403-1, Pigment Yellow 404, Pigment Yellow 405, Pigment Yellow 406, Pigment Yellow 407, Pigment Yellow 5, etc. of legal pigments; other acid dyes such as Acid Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N,N’-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; inorganic black pigments such as black iron oxide and lower-order titanium oxide;Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and navy blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, cateenal, capsanthin, chalcone, calcein, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin, etc., naphthoquinones, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, rutin, etc., natural pigments and dyes; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, etc. and their salts; auto-oxidation type dyes such as indoline; dihydroxyacetone is preferably mentioned.;

[0055] As spices, there are acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoeugenol, isobutyl quinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galaxolide, carvacrol, L-carboxylic, camphor, canon, carrot seed oil, clove oil, methyl caffeate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethyl benzyl carbinyl acetate, styrallyl acetate, cedryl acetate, terpinyl acetate, p-t-butyl cyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronellol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damasconene, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, triplal, nerol, nonanal, 2,6-Nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, ptychoglenn oil, hexyl cinnamaldehyde, cis-3-hexenol, Peru balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrh resinoid, musk ketone, methyl nonyl acetaldehyde, γ-methyl ionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lilal, lilyal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances and natural fragrances such as various essential oils, and various compounded fragrances are preferably mentioned.

[0056] As water, in addition to tap water and purified water, hard water, soft water, natural water, deep ocean water, electrolyzed alkaline ion water, electrolyzed acidic ion water, ion water, and cluster water are preferably mentioned.

[0057] In addition to these, components described in cosmetic raw material standards, ingredient specifications for different types of cosmetics, the list of ingredient display names of the Japan Cosmetic Industry Association, the INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, the Japanese Pharmacopoeia, pharmaceutical additive standards, the Food Additive Codex, etc., and components described in Japanese and foreign patent gazettes and patent publication gazettes (including published gazettes and re-published gazettes) belonging to the classifications of A61K7 and A61K8 in the International Patent Classification IPC, etc., known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. can be contained in known combinations and mixing ratios and amounts.

[0058] Examples of the types of cosmetics of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, body cosmetics, etc. The cosmetics of the present invention can be manufactured according to ordinary methods.

[0059] When the types of the cosmetics of the present invention are described in more detail, as hair cosmetics, shampoos such as oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, shampoo for hair color, integrated rinse shampoo, etc.; hair care agents such as rinse, conditioner, treatment, hair pack, leave-on treatment, hair mist, hair oil, etc.; hair styling agents such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, tic, etc.; hair dyes such as color lotion, hair color treatment, hair manicure, oxidative hair dye, etc.; hair tonic, hair liquid, hair blow, sideburn coat, permanent wave agent, straight perm agent, hair bleach, hair color pretreatment, hair color aftertreatment, perm pretreatment, perm aftertreatment, hair growth agent are preferably mentioned.

[0060] Examples of skin care cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, liposome lotion, etc.; emulsions such as emollient emulsion, moisturizing emulsion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizing emulsion, massage lotion, cutin smoother, elbow lotion, hand lotion, body lotion, etc.; creams such as emollient cream, nourishing cream, nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, cutin softening cream, etc.; gels such as moisturizing gel, whitening gel, all-in-one gel, etc.; beauty essences such as moisturizing essence, whitening essence, moisturizing serum, whitening serum, etc. Examples of sun protection cosmetics include sun protectants, sun protectors, UV care milk, sunscreen, etc. Examples of pack and mask products include peel-off packs, powder packs, washing packs, oil packs, cleansing masks, etc. Examples of cleansing cosmetics include cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils, etc. Examples of facial cleansers include paste facial cleansing foam, gel facial cleansing foam, foaming facial cleansing foam, facial cleansing powder, toilet soap, transparent soap, medicinal soap, liquid soap, beard shaving soap, etc. are preferably mentioned.

[0061] Examples of makeup cosmetics preferably include lipsticks, lip glosses, foundations, blushes, face powders, concealers, eyeliners, mascaras, eyeshadows, eyebrow pencils, eyebrow brushes, nail enamels, enamel removers, nail treatments.

[0062] Examples of fragrance cosmetics preferably include perfumes, perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, compound perfumes, fragrant powders, perfume soaps, body lotions, bath oils.

[0063] Examples of body cosmetics include body cleansing products such as body shampoo, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other anti - odor cosmetics, depigmenting agents, hair removal and epilating agents, bath agents, and insect repellents such as insect repellent sprays.

[0064] Examples of the types of the external skin preparations of the present invention preferably include ointments, lotions, creams or gel - like external skin preparations, patches, liniments, liquid coating agents, etc. Further, it can also be used as oral cosmetics such as toothpaste and mouthwash.

[0065] Examples of the dosage forms of the cosmetics or external skin preparations of the present invention preferably include emulsion - type cosmetics such as oil - in - water (O / W) type, water - in - oil (W / O) type, W / O / W type, O / W / O type, oily cosmetics, solid cosmetics, liquid cosmetics, paste - like cosmetics, stick - like cosmetics, volatile oil - type cosmetics, powder cosmetics, jelly - like cosmetics, gel - like cosmetics, paste - like cosmetics, emulsion polymer - type cosmetics, sheet - like cosmetics, mist - like cosmetics, spray - type cosmetics and other dosage forms.

[0066] The present invention will be described in more detail with the following examples, but the present invention is not limited to these. In these examples, the zeta potential was measured using a Zeta Sizer Nano - ZS manufactured by Malvern.

[0067] <Preparation 1 of the composition for preparing liposomes of the present invention> The composition for preparing liposomes of the present invention was prepared with the compositions shown in Tables 1 - 2. Using the obtained composition for preparing liposomes, liposome solutions were prepared according to the liposome solution formulations described below. For the obtained liposome solutions, the zeta potential and pH were measured, and the dispersion stability was evaluated. The results are also shown in the lower parts of Tables 1 - 2. Liposome solution formulation Component Dosage (mass%) --------------------------------- Composition for Preparing Liposomes 1.0 1,3-Butylene Glycol 9.2 Methylparaben 0.1 Purified Water 89.7 --------------------------------- Method for preparing liposome solution The composition for preparing liposomes was added to 1,3-butylene glycol, and stirred and mixed at 80 °C to prepare a polyhydric alcohol solution. The obtained polyhydric alcohol solution was added to purified water in which methylparaben had been previously dissolved, while stirring at 80 °C, and stirred with a homomixer (75 °C, 5000 rpm, 15 minutes), and then cooled. Method for evaluating dispersion stability Regarding the obtained liposome solution, the appearance after storage at 40 °C for 2 weeks was visually observed, and the dispersion stability was evaluated according to the following evaluation criteria. ◎···No change in appearance from the initial state 〇···Slight change in appearance from the initial state △···Some change in appearance from the initial state ×···Large change in appearance from the initial state

[0068]

Table 1

[0069]

Table 2

[0070] From the results in Tables 1 and 2, it was found that the composition for preparing liposomes of the present invention containing component (A1) and component (A2) as liposome membrane components can obtain liposomes with a positive zeta potential, that is, liposomes with a positively charged surface, by dispersing them in water. The zeta potential of the composition for preparing liposomes that does not contain component (A2) was negative. Also, from the results in Table 1, when lecithin with a PC content of 96% by mass was used as component (A1), it was found that the zeta potential becomes positive when component (A2) is blended in an amount of 0.2 parts by mass or more per 100 parts by mass of component (A1). Further, from the results in Table 2, when lecithin with a PC content of 76% by mass was used as component (A1), it was considered that the zeta potential becomes positive when component (A2) is blended in an amount more than 2.0 parts by mass per 100 parts by mass of component (A1).

[0071] <Preparation 2 of the Composition for Preparing Liposomes of the Present Invention> A composition for preparing liposomes was prepared with the composition shown in Table 3, further blending phytosterol of component (A3) as a liposome membrane component. Using the obtained composition for preparing liposomes, a liposome solution was prepared in the same manner as described above. For the obtained liposome solution, the zeta potential and pH were measured, and the long-term dispersion stability was evaluated. The results are also shown in the lower part of Table 3. Method for evaluating long-term dispersion stability Regarding the obtained liposome solution, the appearance after storage at 40°C for 6 months was visually observed, and the dispersion stability was evaluated according to the following evaluation criteria. ◎···No change in appearance from the initial state 〇···Slight change in appearance from the initial state △···Some change in appearance from the initial state ×···Large change in appearance from the initial state

[0072]

Table 3

[0073] From the results in Table 3, it was found that the liposomes prepared by the composition for preparing liposomes of the present invention are excellent in long-term dispersion stability by further blending component (A3) as a liposome membrane component.

[0074] <Preparation 3 of the composition for preparing liposomes of the present invention> The composition for preparing liposomes of the present invention was prepared with the composition shown in Table 4. 10 parts by mass of the obtained composition for preparing liposomes was added to 90 parts by mass of purified water while stirring at 80°C, and stirred with a homomixer (75°C, 5000 rpm, 15 minutes), and then cooled. The zeta potential of the obtained liposome solution was measured. The results are also shown in the lower part of Table 4.

[0075]

Table 4

[0076] From the results in Table 4, it was found that the composition for preparing liposomes of the present invention can obtain liposomes with a positively charged surface by a simple operation of dispersing in water, and various types of components can be used as component (B).

[0077] <Evaluation of storage stability> The composition for preparing liposomes of the present invention was prepared with the composition shown in Table 5. The storage stability of the obtained composition for preparing liposomes was evaluated by the method described below. The results are also shown in the lower part of Table 5. Method for evaluating storage stability Regarding the obtained composition for preparing liposomes, the appearance after storage at 40°C for 1 month or 3 months was visually observed, and the storage stability was evaluated according to the following evaluation criteria. ◎···No crystal precipitation 〇···Slight crystal precipitation △···Some crystal precipitation ×···Much crystal precipitation

[0078]

Table 5

[0079] From the results in Table 5, it was found that the composition for preparing liposomes of the present invention improves storage stability (suppresses crystal precipitation over time) by blending lactic acid, which is an organic acid. In Comparative Example 5 that does not contain phytosphingosine, since there was no precipitation of crystals, it was considered that the crystal precipitation over time of the composition for preparing liposomes of the present invention was derived from phytosphingosine.

[0080] <Evaluation of usability> Using the composition shown in Table 6, a liposome solution was prepared using the composition for preparing liposomes of Example 3 or the composition for preparing liposomes of Comparative Example 1 that does not contain component (A2) of the present invention. Regarding the obtained liposome solution, the usability when applied to the skin by the following method was evaluated, and the results are shown in Table 6. Method for evaluating usability Based on the senses of five panelists, evaluation was carried out according to the following evaluation criteria. The results are shown as the average score of the five panelists. Evaluation criteria 5 points: Considerably better compared to the liposome solution of Comparative Example 1 4 points: Better compared to the liposome solution of Comparative Example 1 3 points: Equivalent compared to the liposome solution of Comparative Example 1 2 points: Worse compared to the liposome solution of Comparative Example 1 1 point: Considerably worse compared to the liposome solution of Comparative Example 1 Method for preparing liposome solution The composition for preparing liposomes was added to 1,3 - butylene glycol and stirred and mixed at 80°C to prepare a polyhydric alcohol solution. The obtained polyhydric alcohol solution was added to purified water in which methylparaben had been previously dissolved while stirring at 80°C, stirred with a homomixer (75°C, 5000 rpm, 15 minutes), and then cooled.

[0081]

Table 6

[0082] From the results in Table 6, it was found that the liposomes prepared using the composition for preparing liposomes of the present invention were superior in terms of usability such as ease of spreading during application, lack of stickiness during drying, and moist feeling after drying, compared to the liposomes prepared using the composition for preparing liposomes that does not contain the component (A2) of the present invention.

[0083] <Evaluation 1 of Skin Penetration> Using Nile red, an oil-soluble fluorescent dye, as an index for the skin penetration of the oil-soluble active ingredient, the penetration of the active ingredient of the liposome solution prepared using the composition for preparing liposomes of the present invention into the skin was evaluated by the method described below. The results are shown in the lower part of Table 7. Skin permeability test method A liposome solution encapsulating Nile red in the liposome membrane was prepared using the composition for preparing liposomes of the present invention with the composition described in Table 7. As a control, a liposome solution was similarly prepared using the composition for preparing liposomes that does not contain the component (A2) of the present invention. Next, a 3D skin model (LabCyte EPI-MODEL) manufactured by J-TEC was sandwiched between silicone plates with holes having a diameter of 5 mm, and the receptor cell was placed in a Franz-type diffusion cell filled with PBS(-). 200 μL of the liposome solution was applied to the skin surface, and after standing for 6 hours in an environment at a temperature of 37°C and a relative humidity of 80%, the skin model was washed with PBS(-) to remove the liposomes adhering to the surface, and then dissolved in 100 mM Tris-HCl buffer (pH 8.0) (containing 1% Triton X-100). The dissolved solution was centrifuged, and the fluorescence intensity of the supernatant after centrifugation was measured using a microplate reader (excitation wavelength 553 nm, fluorescence wavelength 637 nm). Also, the protein concentration in the supernatant was measured by the BCA method. The fluorescence intensity value per 1 μg of protein was calculated from the measured fluorescence intensity and protein concentration, and this fluorescence intensity value was used as an index for skin penetration. The results are shown as relative values when the fluorescence intensity value of the control was set to 100. Method for preparing liposome solution A composition for preparing liposomes and nile red were added to 1,3 - butylene glycol, and the mixture was stirred and mixed at 80°C to prepare a polyhydric alcohol solution. The obtained polyhydric alcohol solution was added to purified water in which methylparaben had been previously dissolved, while stirring at 80°C, and then stirred with a homomixer (75°C, 5000 rpm, 15 minutes) and cooled.

[0084]

Table 7

[0085] From the results in Table 7, it was considered that the liposomes prepared using the composition for preparing liposomes of the present invention were superior in the skin permeability of the oil - soluble active ingredient compared to the liposomes prepared using the composition for preparing liposomes that did not contain the component (A2) of the present invention.

[0086] <Evaluation of Skin Permeability 2> Using fluorescein amine - labeled sodium hyaluronate as an index for the skin penetration of the water - soluble active ingredient, the skin permeability of the active ingredient in the liposome solution prepared using the composition for preparing liposomes of the present invention was evaluated by the method described below. The results are shown in the lower part of Table 8. Skin permeability test method Using the composition described in Table 8, a liposome solution of the present invention was prepared by adding fluorescein amine-labeled sodium hyaluronate (FAHA-L2 manufactured by PG Research) using the composition for preparing liposomes of the present invention. As a control, a liposome solution was similarly prepared using the composition for preparing liposomes of the present invention that does not contain component (A2) of the present invention. Next, a three-dimensional skin model (LabCyte EPI-MODEL) manufactured by J-TEC was sandwiched between silicone plates with holes having a diameter of 5 mm, and the receptor cells were placed in a Franz-type diffusion cell filled with PBS(-). 200 μL of the liposome solution was applied to the skin surface, and after standing for 6 hours in an environment of 37 °C and 80% relative humidity, the skin model was washed with PBS(-) to remove the liposomes adhering to the surface. The obtained skin model was embedded in O.C.T. compound (manufactured by Sakura Finetek) and rapidly frozen, and then sections of the skin cross-section were prepared using a cryostat microtome (manufactured by Sakura Finetek). By observing the obtained skin sections with a fluorescence microscope (BZ-X800 manufactured by Keyence), the fluorescence intensity value (excitation wavelength 470 nm, fluorescence wavelength 525 nm) was measured and used as an index of the permeability of sodium hyaluronate into the skin. The results were shown as relative values when the fluorescence intensity value of the control was set to 100. Method for preparing liposome solution The composition for preparing liposomes was added to 1,3-butylene glycol and stirred and mixed at 80 °C to prepare a polyhydric alcohol solution. The obtained polyhydric alcohol solution was added to purified water in which methylparaben had been previously dissolved while stirring at 80 °C, stirred with a homomixer (75 °C, 5000 rpm, 15 minutes), and cooled. Thereafter, fluorescein amine-labeled sodium hyaluronate was added and stirred.

[0087]

Table 8

[0088] From the results in Table 8, it was considered that the liposomes prepared using the composition for preparing liposomes of the present invention were superior in the permeability of the water-soluble active ingredient to the skin as compared with the liposomes prepared using the composition for preparing liposomes not containing the component (A2) of the present invention.

[0089] The following cosmetics were prepared. These cosmetics are excellent in the permeability of the active ingredient, have excellent usability, are excellent in moisture retention, and contribute to improving the firmness of the skin.

[0090] Example 22 Liposome Solution Component Blending amount (wt%) -------------------------------------- Part A Liposome preparation composition of Example 18 1.0 1,3-Butylene glycol 9.0 Part B Phenoxyethanol 0.5 Purified water Amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0091] Example 23 Liposome Solution Component Blending amount (wt%) -------------------------------------- Part A Liposome preparation composition of Example 19 5.0 Dipropylene glycol 10.0 Part B Phenoxyethanol 0.3 Purified water Amount to make a total of 100 -------------------------------------- (Preparation method) The A part and the B part were each heated to about 80 °C. While stirring with a homomixer (5000 rpm), the A part was added to the B part and cooled.

[0092] Example 24 Liposome solution Component Dosage (wt%) -------------------------------------- A part Composition for preparing liposomes of Example 19 3.0 Ethanol 8.0 1,3 - Butylene glycol 5.0 B part Phenoxyethanol 0.3 Purified water An amount to make a total of 100 -------------------------------------- (Preparation method) The A part and the B part were each heated to about 80 °C. While stirring with a homomixer (5000 rpm), the A part was added to the B part and cooled.

[0093] Example 25 Liposome solution Component Dosage (wt%) -------------------------------------- A part Composition for preparing liposomes of Example 19 1.0 Ethanol 8.0 Dipropylene glycol 5.0 B part Phenoxyethanol 0.3 Purified water An amount to make a total of 100 -------------------------------------- (Preparation method) The A part and the B part were each heated to about 70 °C. While stirring with a propeller (600 rpm), the A part was added to the B part and cooled.

[0094] Example 26 Liposome Solution Component Dosage (wt%) -------------------------------------- Part A Composition for Preparing Liposome of Example 19 3.0 Part B Phenoxyethanol 0.3 Purified water An amount to make a total of 100 -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 70°C. Part A was added to Part B and gently mixed, then passed through a high-pressure emulsifier twice (70 MPa), and the resulting dispersion was cooled.

[0095] Example 27 Liposome Solution Component Dosage (wt%) -------------------------------------- Part A Composition for Preparing Liposome of Example 18 1.0 1,3-Butylene Glycol 10.0 Ceramide 3 0.05 Ceramide 6 0.03 Part B Phenoxyethanol 0.5 Purified water An amount to make a total of 100 -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 80°C. Part A was added to Part B while stirring with a homomixer (5000 rpm), and then cooled.

[0096] Example 28 Liposome Solution Component Dosage (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 18 3.0 Propanediol 10.0 Ceramide 3 0.04 Ceramide 6 0.03 Part B Phenoxyethanol 0.3 Purified water in an amount to make 100 in total -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 70°C. Part A was added to Part B and gently mixed, then passed through a high-pressure emulsifier twice (100 MPa), and the resulting dispersion was cooled.

[0097] Liposome Solution of Example 29 Components Dosage (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 18 1.0 1,3-Butylene Glycol 10.0 Ceramide 3 0.01 Part B Phenoxyethanol 0.3 Purified water in an amount to make 100 in total -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 80°C. Part A was added to Part B while stirring with a homomixer (5000 rpm), and then cooled.

[0098] Liposome Solution of Example 30 Components Dosage (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 18 1.0 1,3-Butylene Glycol 10.0 Lecithin (lysophosphatidylcholine content 70% or more) 0.02 Part B Phenoxyethanol 0.5 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 70°C. While stirring with a propeller (600 rpm), Part A was added to Part B and then cooled.

[0099] Example 31 Skin Lotion Ingredient Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 19 1.0 1,3-Butylene glycol 10.0 Hydrogenated lecithin (lysophosphatidylcholine content 70% or more) 0.1 Adenophora triphylla extract 0.1 Part B Glyceryl caprylate 0.3 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 70°C. While stirring with a propeller (600 rpm), Part A was added to Part B and then cooled.

[0100] Example 32 Skin Lotion Ingredient Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 18 1.8 1,3-Butylene glycol 10.0 Hydrogenated lysophosphatidylcholine (lysophosphatidylcholine content 70% or more) 0.04 Ceramide 3 0.01 Part B Phenoxyethanol 0.5 Purified water in an amount to make 100 in total -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0101] Example 33 Skin Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 18 1.8 1,3-Butylene glycol 10.0 Lysophosphatidylcholine (lysophosphatidylcholine content 70% or more) 0.1 Tsubokusa extract 0.01 Cholesterol 0.01 γ-Oryzanol 0.05 Part B Phenoxyethanol 0.5 Purified water in an amount to make 100 in total -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0102] Example 34 Skin Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.0 1,3 - Butylene glycol 10.0 Stearyl glycyrrhetinate 0.1 Part B Phenoxyethanol 0.5 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0103] Example 35 Skin Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 19 1.0 1,3 - Butylene glycol 8.0 1,2 - Pentanediol 2.0 Tocopherol nicotinate 0.1 Ceramide 3 0.01 Part B Glyceryl caprylate 0.1 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0104] Example 36 Skin Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 19 1.0 1,3 - Butylene glycol 10.0 Section B Tranexamic acid (Nippon Seika) 2.0 Citric acid appropriate amount Phenoxyethanol 0.1 Purified water in an amount that totals 100 -------------------------------------- (Preparation method) Section A and Section B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Section A was added to Section B and then cooled. The pH was adjusted to around 5 with citric acid.

[0105] Example 37 Skin Lotion Component Blending amount (wt%) -------------------------------------- Section A Composition for preparing liposomes of Example 20 1.0 1,3-Butylene glycol 10.0 Section B Purified water in an amount that totals 100 Section C 3-O-Ethyl ascorbic acid (Nippon Seika) 1.5 Citric acid appropriate amount Sodium citrate 0.2 Phenoxyethanol 0.1 Ethanol 10.0 -------------------------------------- (Preparation method) Section A and Section B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Section A was added to Section B and then cooled. Section C was added, and the pH was adjusted to around 4.5 with citric acid.

[0106] Example 38 Skin Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 20 1.0 1,3-Butylene glycol 10.0 Part B Purified water An amount to make a total of 100 Part C 3-O-Ethylascorbic acid (Nippon Fine Chemical) 1.5 Citric acid Appropriate amount Sodium citrate 0.2 Phenoxyethanol 0.1 Ethanol 10.0 Hydrophobized hydroxypropylmethylcellulose 0.2 Sodium pentetate 0.1 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and cooled. Part C was added, and the pH was adjusted to around 4.5 with citric acid.

[0107] Example 39 Skin lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.4 1,3-Butylene glycol 10.0 Part B Purified water An amount to make a total of 100 Part C 3-O-Ethylascorbic acid (Nippon Fine Chemical) 1.0 Tranexamic acid (Nippon Fine Chemical) 1.0 Arbutin (Nippon Fine Chemical) 3.2 Citric acid Appropriate amount Sodium citrate 0.1 Phenoxyethanol 0.1 Ethanol 10.0 Sodium pyrosulfite 0.1 -------------------------------------- (Preparation method) Part A and Part B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. Part C was added, and the pH was adjusted to around 4.5 with citric acid.

[0108] Example 40 Skin Lotion Component Dosage (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.0 1,3 - Butylene Glycol 10.0 Part B Purified water An amount to make a total of 100 Part C Sodium Hyaluronate (molecular weight 50,000 - 500,000) 0.1 Part D Sodium Hyaluronate (molecular weight 1,000,000 - 1,500,000) 0.1 Glycyrrhizic Acid 2K 0.2 3 - O - Ethyl Ascorbic Acid (Nippon Fine Chemical) 1.0 Tranexamic Acid (Nippon Fine Chemical) 1.0 Arbutin (Nippon Fine Chemical) 6.5 Citric Acid Appropriate amount Sodium Citrate 0.2 Phenoxyethanol 0.1 Ethanol 10.0 Sodium Pyrosulfite 0.05 -------------------------------------- (Preparation method) Part A and Part B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. Parts C and D were added, and citric acid was used to adjust the pH to around 5.

[0109] Example 41 Skin Lotion Component Blending Ratio (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 19 1.0 1,3-Butylene Glycol 10.0 Part B Purified Water in an amount to make a total of 100 Part C Sodium Hyaluronate (molecular weight 300,000 - 1,000,000) 0.1 Part D Glycyrrhizic Acid 2K 0.2 Heparin Analogue 0.1 Pullulan 0.05 Hydrolyzed Collagen 0.1 Citric Acid Appropriate amount Sodium Citrate 0.1 Phenoxyethanol 0.3 Artemisia princeps Extract 0.3 -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. Parts C and D were added, and the pH was adjusted to around 5.5 with citric acid.

[0110] Example 42 Skin Lotion Component Blending Ratio (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 19 1.0 1,3-Butylene Glycol 10.0 Part B Purified Water in an amount to make a total of 100 Part C Carbomer (2% aqueous solution, neutralized with KOH) 10.0 Part D Glycyrrhizic Acid 2K 0.1 Tremoist-SL (Nippon Seika) 5.0 Artemisia princeps Pamp. extract 0.3 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. After adding Part C to make it uniform, Part D was added and stirred until uniform.

[0111] Example 43 Skin lotion Component Dosage (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.0 1,3-Butylene glycol 2.0 Dipropylene glycol 3.0 Part B Purified water An amount to make a total of 100 Part C Sodium hyaluronate (molecular weight 1.5 million - 2 million) 0.1 Part D Carbomer (2% aqueous solution, neutralized with KOH) 10.0 Glyceryl caprylate 0.3 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. After adding Part C to make it uniform, Part D was added and stirred until uniform.

[0112] Example 44 Skin lotion Component Dosage (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 18 1.0 Glycerin 3.0 1,2 - Hexanediol 1.0 Part B Phenoxyethanol 0.5 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0113] Example 45 Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.0 PrimeLipid PI (Nippon Fine Chemical) 0.1 Glycerin 3.0 1,2 - Pentanediol 2.0 Part B Phenoxyethanol 0.5 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0114] Example 46 Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 2.0 1,3 - Butylene glycol 5.0 1,2 - Pentanediol 2.0 Propylene glycol 1.0 Section B Phenoxyethanol 0.5 Purified water in an amount such that the total is 100 -------------------------------------- (Preparation method) Section A and Section B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Section A was added to Section B and then cooled.

[0115] Example 47 Skin Lotion Ingredient Blending amount (wt%) -------------------------------------- Section A Composition for preparing liposomes of Example 19 3.0 Dipropylene glycol 8.0 1,2 - Pentanediol 2.0 Ceramide 1 0.03 Ceramide 2 0.03 Ceramide 3 0.1 Ceramide 4 0.02 Ceramide 5 0.01 Ceramide 6 0.05 Section B Phenoxyethanol 0.5 Purified water in an amount such that the total is 100 -------------------------------------- (Preparation method) Section A and Section B were each heated to approximately 80°C. While stirring with a homomixer (5000 rpm), Section A was added to Section B and then cooled.

[0116] Example 48 Skin Lotion Ingredient Blending amount (wt%) -------------------------------------- Section A Composition for preparing liposomes of Example 19 2.0 1,3-Butylene glycol 6.0 Ethanol 2.0 Astaxanthin 0.01 Tocopherol 0.03 Part B Artemisia princeps extract 0.1 Glucosylrutin 0.1 Ethylhexylglycerin 1.5 Purified water in an amount to make 100 in total -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0117] Example 49 Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 2.0 Propylene glycol 6.0 Dipropylene glycol 4.0 Coenzyme Q10 0.1 Part B Artemisia princeps extract 0.1 Ethylhexylglycerin 1.0 Etidronic acid tetrasodium 0.05 Purified water in an amount to make 100 in total -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled.

[0118] Example 50 Lotion Component Blending amount (wt%) -------------------------------------- Section A Composition for Preparing Liposomes of Example 19 2.0 1,3-Butylene Glycol 6.0 Dipropylene Glycol 4.0 Section B Purified Water in an amount to make 100 in total Section C Inulin-SC (Nippon Seika) 0.7 Ascorbic Acid 2-Glucoside 2.0 KOH Appropriate amount EDTA-4Na 0.1 Phenoxyethanol 0.01 Ethylhexylglycerin 0.8 -------------------------------------- (Preparation Method) Section A and Section B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Section A was added to Section B and then cooled. Section C was added and the pH was adjusted to around 6 with KOH.

[0119] Example 51 Lotion Ingredient Blending Amount (wt%) -------------------------------------- Section A Composition for Preparing Liposomes of Example 19 2.0 1,3-Butylene Glycol 6.0 Dipropylene Glycol 4.0 PrimeLipid PI (Nippon Seika) 0.2 Section B Purified Water in an amount to make 100 in total Section C Inulin-SC (Nippon Seika) 1.0 Ascorbic Acid 2-Glucoside 2.0 KOH Appropriate amount Etidronic Acid-4Na 0.1 Phenoxyethanol 0.01 Ethylhexylglycerin 0.8 -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. Part C was added, and the pH was adjusted to around 6 with potassium hydroxide.

[0120] Example 52 Lotion Component Blending Amount (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 19 0.5 1,3-Butylene Glycol 6.0 Part B Purified Water in an amount to make a total of 100 Part C Ascorbic Acid 1.0 Ethanol 10.0 Citric Acid Appropriate amount Sodium Citrate 0.1 EDTA-2Na 0.1 Phenoxyethanol 0.3 Ethylhexylglycerin 0.8 -------------------------------------- (Preparation Method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B and then cooled. Part C was added, and the pH was adjusted to around 5 with citric acid.

[0121] Example 53 Lotion Component Blending Amount (wt%) -------------------------------------- Part A Composition for Preparing Liposomes of Example 19 1.0 1,3 - Butylene glycol 6.0 Part B Purified water in an amount such that the total is 100 Part C Pentetate 5Na 0.07 EDTA - 4Na 0.03 Phenoxyethanol 0.3 Ethylhexylglycerin 0.8 Neosolue - AquaS (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Part A and Part B were each heated at approximately 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B, cooled, and Part C was added.

[0122] Example 54 Skin Lotion Ingredient Dosage (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 1.0 1,3 - Butylene glycol 6.0 Part B Purified water in an amount such that the total is 100 Part C Carbomer (2% aqueous solution, neutralized with KOH) 5.0 EDTA - 4Na 0.03 Phenoxyethanol 0.3 Ethylhexylglycerin 0.8 Neosolue - Aqulio (Nippon Seika) 0.5 -------------------------------------- (Preparation method) Part A and Part B were each heated at approximately 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B, cooled, and Part C was added.

[0123] Example 55: Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 19 1.0 1,3 - Butylene glycol 6.0 Part B Purified water An amount to make a total of 100 Part C Carbomer (2% aqueous solution, neutralized with KOH) 5.0 Glyceryl caprylate 0.1 Ethylhexylglycerin 0.3 Neosolue - Aqulio (Nippon Fine Chemical) 1.0 Part D PrimeLipid ALPA (Nippon Fine Chemical) 0.1 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 70°C. Part A was added to Part B, and after gently mixing, it was passed through a high - pressure emulsifier twice (100 MPa). The obtained dispersion was cooled, and Parts C and D were each added and stirred until uniform.

[0124] Example 56: Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposome of Example 19 5.0 Dipropylene glycol 8.0 Ethanol 4.0 Plandool - LG1 (Nippon Fine Chemical) 0.05 Part B Purified water An amount to make a total of 100 Part C Sodium hyaluronate (molecular weight 500,000 - 5,000,000) 0.1 Part D (Acrylic acid / lauryl methacrylate / isodecyl methacrylate) Crosspolymer (3% aqueous solution, neutralized with NaOH) 3.0 Glyceryl caprylate 0.1 Neosolue-AquaS (Nippon Fine Chemical) 1.5 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B, cooled, and Parts C and D were added.

[0125] Example 57 Lotion Component Blending amount (wt%) -------------------------------------- Part A Composition for preparing liposomes of Example 19 5.0 Dipropylene glycol 8.0 Ethanol 4.0 1,2-Pentanediol 1.0 Plandool-MAS (Nippon Fine Chemical) 0.1 Part B Purified water An amount to make 100 in total Part C Hydrophobized hydroxypropylmethylcellulose 0.2 (PEG-240 / decyltetradeceth-20 / HDI) Copolymer 0.02 Glyceryl caprylate 0.5 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 -------------------------------------- (Preparation method) Part A and Part B were each heated at about 80°C. While stirring with a homomixer (5000 rpm), Part A was added to Part B, cooled, and Parts C and D were added.

[0126] Example 58 Emulsion Component Blending Ratio (wt%) -------------------------------------- Part A Phytocompo-PP (Nippon Seika) 1.0 Glycerin 5.0 1,3-Butylene Glycol 9.0 Part B Plandool-LG1 (Nippon Seika) 1.0 Plandool-LG2 (Nippon Seika) 1.0 Plandool-LG3 (Nippon Seika) 1.0 Plandool-MAS (Nippon Seika) 1.0 LUSPLAN PI-DA (Nippon Seika) 0.5 Cetyl Ethylhexanoate 5.0 Cetanol 1.2 Oleyl Alcohol 1.0 Cholesterol 0.8 Part C Carbomer (2% Aqueous Solution, Neutralized with KOH) 5.0 Phenoxyethanol 0.3 Part D Purified Water in an amount to make a total of 100 Part E Liposome Solution of Example 24 30.0 -------------------------------------- (Preparation Method) Part A was heated to 70°C and uniformly dispersed. After heating Part B to 70°C and uniformly dissolving it, it was added to Part A and uniformly dispersed (Part F). Part D, which had been pre-heated to about 70°C, was added to Part F, and emulsification was carried out using a homomixer. After cooling to around 40°C, Part C and Part E were added and stirred with a propeller to mix uniformly.

[0127] Example 59 Emulsion Component Blending Ratio (wt%) -------------------------------------- Part A Phytocompo-C (Nippon Seika) 1.0 Glycerin 6.0 1,3-Butylene Glycol 8.0 Part B LUSPLAN SR-DM4 (Nippon Seika) 1.0 Plandool-MAS (Nippon Seika) 0.3 Glyceryl Tri (caprylate / caprate) 3.0 Stearyl Alcohol 2.5 Arachidyl Alcohol 1.0 Isostearyl Glyceryl Ether 0.5 Part C Carbomer (2% aqueous solution, neutralized with KOH) 5.0 Phenoxyethanol 0.3 Part D Purified Water in an amount to make a total of 100 Part E Liposome solution of Example 28 30.0 ------------------------------------- (Preparation Method) Part A was heated to 70°C and uniformly dispersed. After heating Part B to 70°C and uniformly dissolving it, it was added to Part A and uniformly dispersed (Part F). Part D, which had been preheated to about 70°C, was added to Part F and emulsified using a homomixer. After cooling to around 40°C, Parts C and E were added and stirred with a propeller to mix uniformly.

[0128] Example 60 Cream Ingredient Blending Amount (wt%) -------------------------------------- Part A Phytocompo-PP (Nippon Seika) 1.0 Glycerin 5.0 1,3-Butylene Glycol 9.0 Part B Plandool-H (Nippon Seika) 1.5 Glyceryl Tri (caprylate / caprate) 2.0 Behenyl Alcohol 1.0 Stearyl Alcohol 3.2 Arachidyl Alcohol 1.8 Tsubokusa Extract 0.1 Stearyl Glycyrrhetinate 0.05 Part C Tremoist-SL (Nippon Seika) 5.0 Glyceryl Caprylate 0.3 Xanthan Gum 0.1 Part D Purified Water in an amount to make a total of 100 Erythritol 0.3 Inulin-SC (Nippon Seika) 0.5 Part E Liposome Solution of Example 26 30.0 -------------------------------------- (Preparation Method) Part A was heated to 70°C and uniformly dispersed. After heating Part B to 70°C and uniformly dissolving it, it was added to Part A and uniformly dispersed (Part F). Part D, which had been preheated to about 70°C, was added to Part F and emulsified using a homomixer. After cooling to around 40°C, Part C and Part E were added and stirred with a propeller to mix uniformly.

[0129] Example 61 Cream Components Blending Amount (wt%) -------------------------------------- Part A Phytocompo-PP (Nippon Seika) 1.0 Glycerin 5.0 1,3-Butylene Glycol 9.0 Part B Plandool-SUN (Nippon Seika) 0.5 Plandool-ISS (Nippon Seika) 1.0 Plandool-G (Nippon Seika) 1.3 Plandool-H (Nippon Seika) 0.5 Plandool-LG4 (Nippon Seika) 0.1 Ethylhexyl palmitate 2.0 Carnauba wax 0.5 Cetyl palmitate 0.8 Behenyl alcohol 1.0 Cetanol 2.0 γ-Oryzanol 0.3 Part C Carbomer (2% aqueous solution, neutralized with KOH) 3.0 Tremoist-SL (Nippon Seika) 2.0 Phenoxyethanol 0.3 Xanthan gum 0.1 Part D Purified water in an amount to make a total of 100 Xylitol 0.3 Part E Liposome solution of Example 25 30.0 -------------------------------------- (Preparation method) Part A was heated to 70°C and uniformly dispersed. Part B was heated to 70°C and uniformly dissolved, then added to Part A and uniformly dispersed (Part F). Part D, preheated to about 70°C, was added to Part F and emulsified using a homomixer. After cooling to around 40°C, Part C and Part E were added and stirred with a propeller for uniform mixing.

[0130] Example 62 Scalp / Hair Treatment without Rinsing Ingredient Amount of formulation (wt%) -------------------------------------- Part A Neosolue-Aqulio (Nippon Seika) 1.0 Neosolue-DiSM (Nippon Seika) 0.5 Elucaractone DES (Nippon Seika) 0.5 Ethanol 20.0 PEG / PPG-20 / 20 dimethicone 0.2 PEG-12 dimethicone 0.4 Section B Triethanolamine 0.1 Purified water in an amount such that the total is 100 (Acrylates / Alkyl Acrylate (C10 - 30)) Crosspolymer 0.1 Tremoist - TP (Nippon Seika) 0.01 (Acryloyldimethyltaurine Ammonium / VP) Copolymer 0.1 (Acryloyldimethyltaurine Ammonium / Behenyl Methacrylate - 25) Crosspolymer 0.1 Phenoxyethanol 0.2 Section C Inulin - SC (Nippon Seika) 1.0 Ethanol 10.0 t - Flavanone 1.0 Menthol 0.1 Menthyloxypropyl Glycerol Ether 0.15 Panthenyl Ethyl Ether 0.2 Camphor 0.1 Cordyceps Sinensis Extract 1.0 Centella Extract 1.0 Loquat Leaf Extract 1.0 Red Pepper Extract 0.01 Trehalose 0.2 Thymol - 5 - ol 0.1 Tocopheryl Acetate 0.05 Purified water 10.0 Section D Liposome solution of Example 28 20.0 -------------------------------------- (Preparation Method) Part A was heated to about 50°C and dissolved. Next, Part B was uniformly dispersed to form a viscous liquid. Then, Parts C and D were added and uniformly mixed.

[0131] Example 63 Hair Tonic Ingredient Dosage (wt%) ------------------------------------- Liposome solution of Example 25 20.0 Glycerin 2.0 PEG-60 Hydrogenated Castor Oil 0.1 Betaine 0.5 Ethanol 20.0 Menthol 0.1 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Orange Oil 0.05 Panthenyl Ethyl Ether 0.2 Glutamic Acid 0.1 Polychlorinated Dimethyl Methylene Piperidinium Solution 0.1 Carrot Extract 1.0 Clara Extract 2.0 Chlorella Extract 1.0 Trehalose 0.5 Nicotinamide 1.0 Piroctone Olamine 0.1 Dipotassium Glycyrrhizinate 0.05 Purified Water in an amount to make a total of 100 ------------------------------------- (Preparation Method) Weighed all the components into a container and stirred with a paddle at room temperature to make a uniform solution.

[0132] Example 64 Hair Tonic Component Dosage (wt%) ------------------------------------- Liposome solution of Example 26 20.0 Glycerin 2.0 PEG-60 Hydrogenated Castor Oil 0.1 Betaine 0.5 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Inulin-SC (Nippon Fine Chemical) 1.0 Ethanol 10.0 t-Flavanone 1.0 Menthol 0.1 Menthyloxypropyl Glyceryl Ether 0.15 Panthenyl Ethyl Ether 0.2 Camphor 0.1 Cordyceps Extract 1.0 Centella Extract 1.0 Loquat Leaf Extract 1.0 Hydrolyzed Hyaluronic Acid 0.02 Sodium Lysophosphatidic Acid Cyclic 0.001 Red Pepper Extract 0.01 Betaine 0.3 Trehalose 0.2 Thymol 0.1 Tocopheryl Acetate 0.05 β-Glycyrrhetinic Acid 0.05 Purified Water in an amount to make a total of 100 ------------------------------------- (Preparation Method) Weighed all the ingredients into a container and stirred with a paddle at room temperature to make a homogeneous liquid.

[0133] Example 65 Lotion Ingredient Dosage (wt%) -------------------------------------- Part A Liposome Solution of Example 26 50.0 Part B Allantoin 0.2 Carbomer (2% Aqueous Solution, Neutralized with KOH) 3.0 Salicylic Acid 0.1 Phenoxyethanol 0.5 Purified Water in an amount to make a total of 100 -------------------------------------- (Preparation Method) Part B was added to Part A and stirred with a paddle until it became uniform.

[0134] Example 66 Lotion Component Dosage (wt%) -------------------------------------- Part A Liposome solution of Example 23 30.0 Part B Nicotinamide 2.0 Carbomer (2% aqueous solution, neutralized with KOH) 3.0 Dipotassium glycyrrhizinate 0.05 Phenoxyethanol 0.5 Purified water An amount to make a total of 100 -------------------------------------- (Preparation method) Part B was added to Part A and stirred with a paddle until it became uniform.

[0135] Example 67 Lotion Component Dosage (wt%) -------------------------------------- Part A Liposome solution of Example 23 30.0 Part B Magnesium ascorbyl phosphate 2.0 Xanthan gum (3% aqueous solution) 10.0 Dipotassium glycyrrhizinate 0.15 Phenoxyethanol 0.5 Purified water An amount to make a total of 100 -------------------------------------- (Preparation method) Part B was added to Part A and stirred with a paddle until it became uniform.

[0136] Example 68 Lotion Ingredient Blending Ratio (wt%) -------------------------------------- Part A Liposome solution of Example 28 50.0 Part B Nicotinamide 5.0 Carbomer (2% aqueous solution, neutralized with KOH) 3.0 Tranexamic acid (Nippon Fine Chemical) 2.0 Phytic acid 0.3 Phenoxyethanol 0.3 Caffeine 0.1 Acetylated hyaluronic acid 0.1 Purified water An amount that totals 100 -------------------------------------- (Preparation Method) Part B was added to Part A and stirred with a paddle until uniform.

[0137] Example 69 Skin Lotion Ingredient Blending Ratio (wt%) -------------------------------------- Part A Liposome solution of Example 23 40.0 Part B Nicotinamide 5.0 3-O-Ethylascorbic acid (Nippon Fine Chemical) 2.0 Acetylated hyaluronic acid 0.05 Purified water An amount that totals 100 -------------------------------------- (Preparation Method) Part B was added to Part A and stirred with a paddle until uniform.

[0138] Example 70 Skin Lotion Ingredient Blending Ratio (wt%) -------------------------------------- Part A Liposome solution of Example 28 50.0 Part B Placenta extract 0.01 Glycyrrhizic acid 2K 0.1 Carbomer (2% aqueous solution, neutralized with KOH) 3.0 Tranexamic acid (Nippon Fine Chemical) 2.0 Phytic acid 0.3 Phenoxyethanol 0.3 Purified water An amount to make 100 in total -------------------------------------- (Preparation method) Part B was added to Part A and stirred with a paddle until homogeneous.

[0139] Lotion of Example 71 Ingredient Dosage (wt%) -------------------------------------- Part A Liposome solution of Example 28 50.0 Part B 3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.1 Isopropylmethylphenol 0.1 Tranexamic acid (Nippon Fine Chemical) 2.0 Phenoxyethanol 0.3 Purified water An amount to make 100 in total -------------------------------------- (Preparation method) Part B was added to Part A and stirred with a paddle until homogeneous.

[0140] Lotion of Example 72 Ingredient Dosage (wt%) -------------------------------------- Part A Liposome solution of Example 28 50.0 Part B 3 - O - Ethylascorbic acid (Nippon Seika) 1.5 Isopropylmethylphenol 0.1 Ascorbic acid 5.0 Tranexamic acid (Nippon Seika) 1.0 Allantoin 0.1 Urea 1.0 Cyanocobalamin 0.001 Ascorbyl palmitate phosphate 3Na 0.1 Phenoxyethanol 0.3 1,2 - Pentanediol 1.5 Ethanol 8.0 Citric acid appropriate amount Sodium citrate 0.2 Purified water an amount to make a total of 100 -------------------------------------- (Preparation method) Part B was added to Part A and stirred with a paddle until homogeneous. The amount of citric acid added was adjusted to be around pH 4.5.

[0141] Example 73 Cream Component Blending amount (wt%) -------------------------------------- Part A Isononyl isononanoate 2.0 Tocotrienol 0.02 Diglyceryl stearate 1.5 Glyceryl stearate 1.0 Polysorbate - 20 0.1 PEG - 60 hydrogenated castor oil 0.8 Pyridoxine tripalmitate 1.0 Pyridoxine dipalmitate 1.0 Retinol palmitate 0.005 Eucalyptus oil 0.2 Argania spinosa kernel oil 0.01 Peppermint oil 0.4 Aminocaproic acid 0.2 Pantothenyl alcohol 0.2 Tocopheryl acetate 0.02 Stearyl glycyrrhetinate 0.05 Part B Carbomer 0.01 (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.01 Xanthan gum 0.05 Sodium hydroxide 0.01 Part C Purified water in an amount to make a total of 100 Inulin-SC (Nippon Seika) 0.8 Part D Liposome solution of Example 25 30.0 -------------------------------------- (Preparation method) Part A was heated to 70°C and dissolved uniformly. Part C, which had been preheated to 70°C, was added to Part A and emulsified using a homomixer. After cooling to around 40°C, Part B and Part D were added and stirred with a propeller to mix uniformly.

[0142] Example 74 Cream Component Dosage (wt%) -------------------------------------- Part A Petrolatum 3.0 Glyceryl stearate 1.0 Polysorbate-20 0.1 PEG-60 hydrogenated castor oil 0.8 Jojoba oil 2.0 Macadamia nut oil 1.0 Meadowfoam oil 1.0 Cetanol 3.0 Stearyl glycyrrhetinate 0.2 Tocopheryl nicotinate 0.1 Section B Carbomer 0.01 (Acrylates / Alkyl Acrylate (C10 - 30)) Crosspolymer 0.01 Xanthan gum 0.05 Sodium hydroxide 0.01 Section C Purified water in an amount to make a total of 100 Arbutin (Nippon Seika) 6.0 Inulin - SC (Nippon Seika) 0.8 Section D Liposome solution of Example 25 30.0 -------------------------------------- (Preparation method) Section A was heated to 70°C and dissolved uniformly. Section C, which had been heated to 70°C in advance, was added to Section A and emulsified using a homomixer. After cooling to around 40°C, Section B and Section D were added and stirred with a propeller to mix uniformly.

[0143] Example 75 Lotion Component Dosage (wt%) -------------------------------------- Section A Liposome solution of Example 23 30.0 Section B Sorbitol 1.0 Xanthan gum (3% aqueous solution) 10.0 Glycyrrhizic acid 2K 0.15 Sodium tocopheryl phosphate 1.0 Phenoxyethanol 0.5 Purified water in an amount to make a total of 100 -------------------------------------- (Preparation method) Section B was added to Section A and stirred with a paddle until uniform.

[0144] In the above prescription, the details of the ingredients listed by product name are as follows. 〇Inulin-SC: Inulin 〇LUSPLAN PI-DA: Di(isostearyl / phytosteryl) dimer dilinoleate 〇LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, glyceryl tri(caprylate / caprate) 〇Neosolue-Aqulio: Bis(ethoxydiglycol) cyclohexanedicarboxylate 〇Neosolue-AquaS: Polyglyceryl-10 (eicosanedioate / tetradecanedioate), glycerin 〇Neosolue-DiSM: Diisostearyl malate 〇Phytocompo-PP: Hydrogenated lecithin, phytosterol 〇Phytocompo-C: Hydrogenated lecithin, phytosterol, ceramide 2, ceramide 3, ceramide 6II 〇Plandool-H: (Phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate 〇Plandool-G: Dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate 〇Plandool-ISS: Phytosteryl isostearate 〇Plandool-SUN: Phytosteryl sunflower seed oil fatty acid 〇Plandool-MAS: Phytosteryl macadamia nut oil fatty acid 〇Plandool-LG1: Di(phytosteryl / octyldodecyl / behenyl) lauroyl glutamate 〇Plandool-LG2: Di(phytosteryl / octyldodecyl) lauroyl glutamate 〇Plandool-LG3: Di(phytosteryl / octyldodecyl / behenyl) lauroyl glutamate 〇Plandool-LG4: Di(phytosteryl / octyldodecyl / behenyl) lauroyl glutamate 〇PrimeLipid ALPA: Lysophosphatidic acid, Lysophosphatidylcholine, Glycerin, Water, Aluminum hydroxide 〇PrimeLipid PI: Hydrogenated Lecithin, Phytosterol, Lecithin, Tocopherol 〇Tremoist-TP: Jellyfish polysaccharide 〇Tremoist-SL: Aqueous solution of jellyfish polysaccharide (1%) 〇Erucalactone DES: γ-Docosalactone, Diethyl sebacate

Claims

1. A composition for preparing positively charged liposomes, containing the following components (A) and (B), wherein the content of component (A) is 1 to 30% by mass and the content of component (B) is 70 to 99% by mass. (A) A liposome membrane component containing the following components (A1) and (A2) (A1) Phospholipids (A2) Sphingosines (B) Polyhydric alcohols

2. The composition for preparing liposomes according to claim 1, wherein the phospholipid as component (A1) is lecithin having a phosphatidylcholine content of 60% by mass or more.

3. The composition for preparing liposomes according to claim 2, characterized in that as the liposome membrane component of component (A), it further contains component (A3) sterols.

4. The composition for preparing liposomes according to claim 2 or 3, further characterized by containing an organic acid as component (C).

5. Liposomes obtained by dispersing the composition for preparing liposomes according to any one of claims 1 to 3 in water.

6. Liposomes obtained by dispersing the composition for preparing liposomes according to claim 4 in water.

7. A cosmetic or external skin preparation containing the composition for preparing liposomes according to any one of claims 1 to 3.

8. A cosmetic or external skin preparation containing the composition for preparing liposomes according to claim 4.

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