Slowly dissolving tablet composition and method for producing the same

Abstract

To improve the slow dissolution ability of a slowly dissolving tablet composition.SOLUTION: The present invention provides a composition comprising: a particle group (A) comprising a support in which an active ingredient (a1) is carried by a carrier (a2); and a particle group (B) comprising particles of two or more types of lubricants. The component (a2) is at least one type of particle selected from synthetic zeolite, magnesium aluminum silicate, and anhydrous silica; and the mass ratio (a1 / a2 ratio) of the component (a1) to the component (a2) is preferably less than 1.1.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a sustained-release tablet composition and a method for producing the same.

Background Art

[0002] Sustained-release technology has hitherto been mainly reported for applications in toilet cisterns, on-tanks or toilets, etc. For example, Patent Document 1 discloses a solid detergent for a flush toilet in which a solid deodorant insoluble or hardly soluble in water is dispersed in a sustained-release agent.

[0003] In recent years, it has been considered to apply sustained-release technology to the field of washing of textile products such as clothing, and solid agents formed by melting and molding a high-melting nonionic surfactant or a higher alcohol have been proposed. For example, Patent Document 2 discloses a solid composition for washing treatment containing a water-soluble nonionic surfactant or polyethylene glycol or a copolymer of polyoxyethylene and polyoxypropylene having a melting point of 25°C or higher, a water-insoluble component having a melting point of 50°C or higher, and a functional component. This solid composition for washing treatment is produced by mixing those heated to a temperature equal to or higher than the melting point of each component, pouring the mixture into a mold, and cooling until it solidifies.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] By the way, as a composition to which a sustained-release technology is applied, there is a sustained-release composition (sustained-release tablet composition) of a tablet (tablet) obtained by tableting a mixed powder containing an active ingredient and the like. In such a sustained-release tablet composition, it is necessary to maintain an appropriate hardness and sustained-release property. Therefore, an object of the present invention is to provide a sustained-release tablet composition having excellent sustained-release properties.

Means for Solving the Problems

[0006] As a result of investigations by the present inventors, the following findings were obtained. The mixed powder may form lumps depending on the types of components to be blended. In particular, when a component that circulates as a liquid such as a dispersion or a solution is blended into the mixed powder, the formation of lumps in the mixed powder becomes remarkable. Even if the mixed powder with lumps is formed into a tablet, insufficient strength will occur. In addition, when a component that circulates as a liquid is blended into the mixed powder, the mixed powder easily adheres to the pestle or mortar during tableting, resulting in rough tablet surfaces and poor molding in continuous production, and insufficient strength of the tablet. When the tablet has insufficient strength, the tablet easily disintegrates during use, and the sustained-release property cannot be maintained. The present invention has been made based on the above findings and has the following aspects.

[0007] <1> A group of particles (A) of a carrier in which an active ingredient (a1) is supported on a carrier (a2), A group of particles (B) composed of particles of two or more kinds of lubricants, and The component (a2) is at least one kind of particle selected from zeolite, magnesium aluminosilicate, and anhydrous silicic acid, and the sustained-release tablet composition. <2> The mass ratio (a1 / a2 ratio) of the component (a1) to the component (a2) is less than 1.1, and the sustained-release tablet composition according to <1>. <3> Furthermore, the sustained-release tablet composition according to <1> or <2>, further comprising one or more groups of particles (C) selected from monosaccharides, disaccharides, and oligosaccharides.

[0008] A method for producing a sustained-release tablet composition, comprising: a particle group (A) of a carrier in which an active ingredient (a2) is supported on a carrier (a1), and a particle group (B) composed of particles of two or more lubricants. A step of mixing the component (a1) and the component (a2) to obtain the particle group (A); A step of mixing the particle group (A) and the particle group (B) to obtain a mixed powder; A step of pressure-molding the mixed powder into an arbitrary shape; A method for producing a sustained-release tablet composition, comprising the steps above.

Effect of the Invention

[0009] According to the sustained-release tablet composition of the present invention, it has excellent sustained-release properties.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Figure 3

Figure 4

Embodiments for Carrying out the Invention

[0011] In this specification and the claims, the numerical range represented by "~" means a numerical range including the numerical values before and after "~" as the lower limit value and the upper limit value. The "tablet composition" is a tablet-shaped solid preparation (tablet) that maintains a certain shape at room temperature (for example, 25°C) and is less likely to change in shape over time. "Slow solubility" refers to the property that when in contact with water, the entire tablet composition does not dissolve instantaneously, but a part of the surface or in the vicinity of the tablet composition dissolves. For example, when measuring the weight of a 10 - 15 g tablet composition after immersing it in water at 15°C for 40 minutes, it is preferable that the weight loss before and after immersion is 0.2 - 5.0 g per 10 g of the tablet composition, more preferably 0.5 - 2.5 g, and even more preferably 0.8 - 2.0 g.

[0012] (Slow - soluble tablet composition) The slow - soluble tablet composition of the present invention (hereinafter sometimes simply referred to as "tablet composition") is a solid preparation containing particle group (A) and particle group (B). The tablet composition of the present invention is a so - called tablet, which is a solid preparation obtained by molding powder into an arbitrary shape.

[0013] <Shape> The shape of the tablet composition is not particularly limited, and examples include a shape having a cylindrical part, a shape having a prismatic part, etc.

[0014] When the tablet composition has a shape having a cylindrical part, the tablet composition may be a shape consisting only of the cylindrical part, or may be a shape having a cylindrical part and a bulging part that bulges above and below the cylindrical part.

[0015] When the tablet composition has a shape having a cylindrical part and a bulging part, examples of such a tablet composition include Sumitomo angled flat tablets, Sumitomo round flat tablets, R - tablets (standard R - tablets), two - stage R - tablets, etc. Among these, Sumitomo angled flat tablets and R - tablets are preferable. The bulging parts of these tablets may be asymmetric up and down, but are preferably symmetric up and down.

[0016] Figure 1 is a side view showing an example of a tablet composition 10 having the shape of a Sumitomo angled flat tablet. The tablet composition 10 of this example is a biconvex tablet having a cylindrical part 11, a first bulging part 12, and a second bulging part 13. The diameter of the cylindrical portion 11, that is, the diameter of the top and bottom surfaces of the cylindrical portion 11 is preferably 15.1 mm or more, more preferably 20 to 50 mm, and even more preferably 25 to 35 mm. If the diameter of the cylindrical portion 11 is equal to or greater than the above lower limit value, accidental ingestion can be more effectively prevented. If the diameter of the cylindrical portion 11 is equal to or less than the above upper limit value, it can be gradually dissolved uniformly until the end. The first bulging portion 12 rises linearly from near the periphery of one end face of the cylindrical portion 11 toward the center of the one end face at a predetermined rising angle θ, and any region including the zenith 12A is a plane. The second bulging portion 13 rises linearly from near the periphery of the other end face of the cylindrical portion 11 toward the center of the other end face at a predetermined rising angle θ, and any region including the zenith 13A is a plane. The rising angle θ in the first bulging portion 12 and the rising angle θ in the second bulging portion 13 may be the same or different, and from the viewpoint of tablet strength, it is preferably the same. The thickness H1 of the tablet composition 10, that is, the sum of the thickness of the cylindrical portion 11 and the maximum thicknesses of the first bulging portion 12 and the second bulging portion 13 is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. Note that the tablet composition 10 shown in FIG. 1 has a horizontally planar (land portion 14) annular shape in plan view on the outer periphery of the first bulging portion 12 and a horizontally planar (land portion 15) annular shape in plan view on the outer periphery of the second bulging portion 13. However, for example, it may not have a land portion, and the peripheral portion of the tablet and the bulging rising portion may be in contact.

[0017] FIG. 2 is a side view showing an example of a tablet composition 20 having the shape of an R tablet. The tablet composition 20 of this example has a cylindrical portion 21, a first bulging portion 22, and a second bulging portion 23, and is a biconvex tablet in which the radius of curvature R of the curve of the surface of each of the first bulging portion 22 and the second bulging portion 23 is constant regardless of the position on the surface of the bulging portion. The diameter of the cylindrical portion 21, that is, the diameter of the top and bottom surfaces of the cylindrical portion 21 is the same as the diameter of the cylindrical portion 11 of the tablet composition 10 shown in FIG. 1. The first bulging portion 22 bulges from near the periphery of one end face of the cylindrical portion 21 toward the center of the one end face. The second bulging portion 23 bulges from near the periphery of the other end face of the cylindrical portion 21 toward the center of the other end face. Here, the "radius of curvature of the curve on the surface of the first bulging portion 22" refers to the radius of a circle when the curve drawn by the surface of the first bulging portion 22 is regarded as a part of a circle in a cross section obtained by cutting perpendicularly to the end face of the cylindrical portion 21 so as to pass through the zenith 22A. The "radius of curvature of the curve on the surface of the second bulging portion 23" refers to the radius of a circle when the curve drawn by the surface of the second bulging portion 23 is regarded as a part of a circle in a cross section obtained by cutting perpendicularly to the end face of the cylindrical portion 21 so as to pass through the zenith 23A. The zenith 22A in the first bulging portion 22 is the point located at the highest position with respect to one end face. The zenith 23A in the second bulging portion 23 is the point located at the lowest position with respect to the other end face. The radius of curvature R of the first bulging portion 22 and the radius of curvature R of the second bulging portion 23 may be the same or different, and from the viewpoint of tablet strength, it is preferably the same. The thickness H2 of the tablet composition 20, that is, the sum of the thickness of the cylindrical portion 21 and the maximum thicknesses of the first bulging portion 22 and the second bulging portion 23 is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. Note that the tablet composition 20 shown in FIG. 2 has a horizontally annular horizontal surface (land portion 24) in a plan view on the outer periphery of the first bulging portion 22 and a horizontally annular horizontal surface (land portion 25) in a plan view on the outer periphery of the second bulging portion 23. However, for example, it may not have a land portion, and the peripheral portion of the tablet and the bulging rising portion may be in contact with each other.

[0018] When the tablet composition has a shape consisting only of a cylindrical portion, the diameter of the cylindrical portion is the same as the diameter of the cylindrical portion 11 of the tablet composition 10 shown in FIG. 1. Also, the height of the cylindrical portion, that is, the thickness of the tablet composition consisting only of the cylindrical portion is preferably 5 to 20 mm, more preferably 8 to 17 mm, and even more preferably 12 to 16 mm. The tablet composition consisting only of a cylindrical portion may be flat. When it is flat, the aspect ratio (diameter of the cylindrical portion / height H of the cylindrical portion) is preferably from 1 to 10, more preferably from 1.2 to 5, and even more preferably from 1.5 to 2.5.

[0019] Further, when the tablet composition has a shape consisting only of a cylindrical portion, a concave portion may be provided on at least one of the surfaces of the cylindrical portion, specifically, the top surface and the bottom surface of the cylindrical portion. FIG. 3(a) is a perspective view showing an example of a tablet composition 30 having a shape with a concave portion provided on the surface, and FIG. 3(b) is a cross-sectional view taken along the line A-A' of the tablet composition 30. The tablet composition 30 shown in FIG. 3 is composed only of a cylindrical portion 31, and a concave portion 32 is provided at the center of the top surface 31a of the cylindrical portion 31. Further, the shape of the cross-section along the thickness H3 direction of the tablet composition 30 is a quadrangle, and its four corners are rounded off.

[0020] The diameter of the cylindrical portion 31, that is, the diameter of the top surface 31a and the bottom surface 31b is preferably 15.1 mm or more, more preferably from 20 to 50 mm, and even more preferably from 25 to 35 mm. If the diameter of the top surface 31a and the bottom surface 31b is at least the above lower limit value, accidental ingestion can be more effectively prevented. If the diameter of the top surface 31a and the bottom surface 31b is at most the above upper limit value, it can be gradually dissolved uniformly until the end.

[0021] The thickness H3 of the tablet composition 30, that is, the thickness of the cylindrical portion 31 is not particularly limited, but for example, it is preferably from 5 to 20 mm, more preferably from 8 to 17 mm, and even more preferably from 12 to 16 mm.

[0022] The depth h of the concave portion 32 is preferably 20 to 40% of the thickness H3 of the tablet composition 30, and more preferably 25 to 35%. If the depth h of the concave portion 32 is at least the above lower limit value, the hardness of the tablet composition 30 is further increased. If the depth h of the concave portion 32 is at most the above upper limit value, it can be easily tabletted and formed. The diameter d of the opening of the recess 32 is preferably 5 to 25 mm, more preferably 7 to 20 mm, and even more preferably 15 to 20 mm. Although the shape of the opening of the recess 32 in the illustrated example is circular, the shape of the opening of the recess 32 is not particularly limited and may be polygonal or elliptical. The volume of the recess 32 is preferably 5 to 25% of the volume of the tablet composition 30, and more preferably 10 to 20%. If the volume of the recess 32 is at least the above lower limit value, the sustained solubility of the tablet composition 30 is further improved. If the volume of the recess 32 is at most the above upper limit value, the hardness of the tablet composition 30 is further increased.

[0023] When the tablet composition has a shape having a prismatic portion, the tablet composition may have a shape consisting only of the prismatic portion, or may have a shape having a prismatic portion and a bulging portion bulging above and below the prismatic portion. When the tablet composition has a shape consisting only of a prismatic portion, a recess may be provided on at least one of the surfaces of the prismatic portion, specifically, the top surface and the bottom surface of the prismatic portion.

[0024] Examples of the tablet composition having a shape with a prismatic portion include a shape in which a cylindrical portion in a tablet composition having a cylindrical portion is changed to a prismatic portion. The diameter of the circumscribed circle of the top surface or the bottom surface of the prismatic portion is preferably 15.1 mm or more, more preferably 20 to 50 mm, and even more preferably 25 to 35 mm. If the diameter of the circumscribed circle of the top surface or the bottom surface of the prismatic portion is at least the above lower limit value, accidental ingestion can be more effectively prevented. If the diameter of the circumscribed circle of the top surface or the bottom surface of the prismatic portion is at most the above upper limit value, it can be dissolved uniformly until the end.

[0025] As the shape of the tablet composition, a shape having a cylindrical portion is preferable. From the viewpoint of further increasing the hardness of the tablet composition, a shape having a cylindrical portion and a bulging portion, or a shape having a recess provided on at least one of the top surface and the bottom surface of the cylindrical portion is more preferable, a shape like a sumi-kaku heikin tablet, or a shape having a recess provided on at least one of the top surface and the bottom surface of the cylindrical portion is even more preferable, and a shape having a recess provided on at least one of the top surface and the bottom surface of the cylindrical portion is particularly preferable.

[0026] The hardness of the tablet composition is preferably 20 to 80 N, more preferably 40 to 70 N. When the hardness of the tablet composition is at least the above lower limit value, it does not easily disintegrate and the sustained solubility can be further enhanced. When the hardness of the tablet composition is at most the above upper limit value, it easily elutes in water and the sustained solubility can be further enhanced. The hardness of the tablet composition is measured by a digital force gauge DST-200N (manufactured by IMADA Co., Ltd.).

[0027] <Particle group (A)> The particle group (A) is a group of carriers (particles) in which the active ingredient (a1) is supported on the carrier (a2). By using the particle group (A) as a group of carriers, the formation of lumps can be suppressed, the strength of the tablet can be increased, and the sustained solubility can be enhanced. Whether the active ingredient (a1) is supported on the carrier (a2) or not can be confirmed by SEM-Raman spectroscopy. The "particle group" is a so-called powder.

[0028] The average particle diameter of the particle group (A) is preferably 20 to 300 μm, more preferably 40 to 250 μm. When the average particle diameter of the particle group (A) is at least the above lower limit value, the disintegration of the tablet composition is promoted and the sustained solubility can be enhanced. When the average particle diameter of the particle group (A) is at most the above upper limit value, the disintegration of the tablet composition is suppressed and the sustained solubility can be further enhanced. In this specification, the average particle diameter is the weight average particle diameter measured by the laser diffraction method.

[0029] The content of the particle group (A) is preferably 30 to 70% by mass, more preferably 40 to 60% by mass, based on the total mass of the tablet composition. When the content of the particle group (A) is at least the above lower limit value, the effect of the component (a1) can be further enhanced. When the content of the particle group (A) is at most the above upper limit value, the hardness can be further increased.

[0030] ≪Active ingredient (a1)≫ The active ingredient (a1) ((a1) component) is a component that imparts a function to the tablet composition. Examples of the (a1) component include microbial inhibitors such as bactericides, fungicides, antibacterial agents, fungicides, or mold inhibitors, deodorants, repellents, ultraviolet absorbers, fluorescent agents, migration inhibitors, fiber surface modifiers, recontamination inhibitors, metal ion scavengers (chelating agents), silicone compounds, fragrances, etc. These active ingredients are known substances, are readily available on the market, and can also be prepared.

[0031] Examples of the microbial inhibitor include dichlorosan, triclosan, benzalkonium chloride, zinc ricinoleate, alkyltrimethylammonium salts, etc.

[0032] Examples of the fungicide include iodothiolane DP95 (compound name: diiodomethyl-p-tolyl sulfone), propynyl iodide butylcarbamate, etc.

[0033] Examples of the deodorant include, for example, methylglycine diacetic acid (MGDA), aspartic acid diacetic acid (ASDA), isoserine diacetic acid (ISDA), β-alanine diacetic acid (ADAA), serine diacetic acid (SDA), glutamic acid diacetic acid (GLDA), iminodiacetic acid (IDS), hydroxyiminodiacetic acid (HIDS), or salts thereof, zinc ricinoleate, bentonite, dextrin, etc.

[0034] Examples of the repellent include known components used as known pest repellents, such as N,N-diethyl-3-methylbenzamide (DEET), ikaridin, etc.

[0035] Examples of the ultraviolet absorber include, for example, 4-methoxy-4'-tert-butyldibenzoylmethane, etc.

[0036] Examples of the fluorescent agent include, for example, 4,4-bis(2-sulfostyryl)biphenyl disodium (trade name "Tinopal CBS-X" manufactured by BASF, etc.).

[0037] Examples of the migration prevention base material include polyvinylpyrrolidone and the like.

[0038] Examples of the anti-fading agent include 1,4-bis(3-aminopropyl)piperazine and the like.

[0039] Examples of the fiber surface modifier include enzymes such as cellulase, amylase, protease, lipase, and keratinase.

[0040] Examples of the anti-recontamination agent include at least one repeating unit selected from the group consisting of alkylene terephthalate units and alkylene isophthalate units, and at least one repeating unit selected from the group consisting of oxyalkylene units and polyoxyalkylene units. Specific examples include water-soluble polymers having such repeating units. Specifically, products with the trade names "TexCare SRN-100" (manufactured by Clariant, weight average molecular weight 2000 - 3000), "TexCare SRN-300" (manufactured by Clariant, weight average molecular weight 7000), "Repel-O-Tex Crystal" (manufactured by Rhodia), "Repel-O-Tex QC" (manufactured by Rhodia), etc. Other anti-recontamination agents include alkylene oxide adducts of polyalkyleneimine and alkylene oxide adducts of polyalkyleneamine. Specifically, products with the trade name "Sokalan HP20" (manufactured by BASF) etc. are included.

[0041] Examples of the metal ion scavenger (chelating agent) include malonic acid, succinic acid, malic acid, diglycolic acid, tartaric acid, citric acid, fumaric acid, etc.

[0042] As the fragrance, those known to be blendable into the treatment agent composition for fiber products can be used without particular limitation. For example, the list of usable fragrance raw materials is described in various literatures such as "Perfume and Flavor Chemicals", Vol.I and II, Steffen Arctander, Allured Pub.Co.(1994), "Synthetic Perfume - Chemistry and Product Knowledge", by Motokazu Indoh, Chemical Industry Daily Co., Ltd.(1996), "Perfume and Flavor Materials of Natural Origin", Steffen Arctander, Allured Pub.Co.(1994), "Encyclopedia of Scents", edited by The Perfume Society of Japan, Asakura Shoten(1989), "Perfumery Material Performance V.3.3", Boelens Aroma Chemical Information Service(1996), "Flower oils and Floral Compounds In Perfumery", Danute Lajaujis Anonis, Allured Pub.Co.(1993), etc.

[0043] The molecular structure of the silicone compound may be linear, branched, or crosslinked. Further, the silicone compound may be a modified silicone compound, and the modified silicone compound may be modified with one kind of organic functional group or may be modified with two or more kinds of organic functional groups. The silicone compound can be used in the state of an oil, or can also be used in the state of an emulsion dispersed by an arbitrary emulsifier. Specific examples of silicone include dimethyl silicone, polyether-modified silicone, methylphenyl silicone, alkyl-modified silicone, higher fatty acid-modified silicone, methylhydrogen silicone, fluorine-modified silicone, epoxy-modified silicone, carboxy-modified silicone, carbinol-modified silicone, amino-modified silicone, and the like. For example, polyoxyethylene-modified silicone (trade name "SH3775M" etc. manufactured by DuPont - Toray Specialty Materials Co., Ltd.) and the like can be mentioned. Examples of the colorant include general-purpose dyes and pigments such as Acid Red 138, Polar Red RLS, Acid Yellow 203, Acid Blue 9, Blue No. 1, Blue No. 205, Green No. 3, Red No. 106, Yellow No. 203, Turquoise P-GR (all are trade names). The above-mentioned component (a1) may be used alone or in combination of two or more.

[0044] As the component (a1), compounds, dispersions, aqueous solutions, etc. that are liquid at normal temperature and flow in a liquid state are preferable. For example, dichlorosan and triclosan are commercially available as dispersions or solutions using propylene glycol as a dispersion medium. Benzalkonium chloride and alkyltrimethylammonium salts are commercially available as dispersions or solutions using water as a dispersion medium.

[0045] In the formulation of the dispersion or solution, the content of the component (a1) is preferably, for example, 50 to 90% by mass.

[0046] Examples of the component (a1) include dichlorosan (trade name "Chinosan HP100" etc. manufactured by BASF), triclosan (trade name "Irgasan DP300" etc. manufactured by BASF), benzalkonium chloride (trade name "Barquat MS100", "Barquat MB80" etc. manufactured by Lonza), zinc ricinoleate (trade name "TEGO Sorb" etc. manufactured by Evonik), and alkyltrimethylammonium salts having 12 to 16 carbon atoms (trade name "Lipocard C12-37W", "Lipocard C50", "Lipocard C16Cl salt", "Lipocard C16MS salt" etc. manufactured by Lion Specialty Chemicals Co., Ltd.).

[0047] <<Carrier (a2)>> The carrier (a2) ((a2) component) is at least one kind of particle selected from zeolite, magnesium aluminosilicate, and anhydrous silicic acid. By including the (a2) component, the tablet composition can suppress the generation of mold, increase the hardness of the tablet, and enhance the sustained solubility.

[0048] The (a2) component may be at least one kind of particle alone selected from zeolite, magnesium aluminosilicate, and anhydrous silicic acid, or may be a composite particle of two or more kinds selected from zeolite, magnesium aluminosilicate, and anhydrous silicic acid. The group of (a2) components contained in the particle group (A) may be one kind alone or a combination of two or more kinds.

[0049] The zeolite may be natural zeolite or synthetic zeolite. Zeolite is a general term for aluminosilicates. The aluminosilicate may be either crystalline or amorphous (non-crystalline). Crystalline aluminosilicates are preferred in terms of cation exchange capacity. As the crystalline aluminosilicate, A-type, X-type, Y-type, P-type zeolites, etc. are suitable. Synthetic zeolite is industrially synthesized among zeolites.

[0050] The average particle diameter of the group of (a2) components is the same as the average particle diameter of the particle group (A).

[0051] (a2) component has a specific surface area of preferably 100 to 400 m 2 / g, more preferably 200 to 300 m 2 / g. When the specific surface area is at least the above lower limit value, the loading amount of the (a1) component can be increased more. When the specific surface area is at most the above upper limit value, the strength of the (a2) component can be increased more.

[0052] In the particle group (A), the mass ratio of the (a1) component to the (a2) component (a1 / a2 ratio) is preferably less than 1.1, more preferably 0.1 to 1.0, and even more preferably 0.2 to 0.9. When the a1 / a2 ratio is at least the above lower limit value, the content of the (a1) component in the tablet composition can be increased to enhance the effect of the (a1) component more. When the a1 / a2 ratio is at most the above upper limit value, the generation of lumps can be suppressed better and the sustained solubility can be enhanced more.

[0053] <<Optional Component>> The particle group (A) may contain an optional component other than the (a1) component and the (a2) component (A particle optional component). Examples of the A particle optional component include a dispersion medium derived from the (a1) component (such as water, ethanol, methanol, propylene glycol, etc.). The content of the A particle optional component is preferably 50 to 90% by mass based on the total mass of the particle group (A).

[0054] <<Particle Group (B)>> The particle group (B) is a group of particles of two or more lubricants. When the tablet composition contains the (B) component, appropriate sustained solubility can be achieved. Also, by using two or more lubricants, when the tablet composition is used in a washing process, the sustained-release component is less likely to remain undissolved, and the adhesion of the undissolved residue to the fiber product after the washing process can be prevented. The "group of particles of two or more lubricants" may include two or more particles composed of a single substance, or a group of particles composed of two or more substances. However, from the perspective of obtaining more appropriate sustained solubility, the "group of particles of two or more lubricants" preferably has an aspect including two or more particles composed of a single substance.

[0055] Examples of the particle group (B) include an oily lubricant ((b1) component) with a temperature below 100°C, an inorganic metal salt-based lubricant (excluding the (b1) component) ((b2) component) with a melting point of 100°C or higher, and the like. Examples of the (b1) component include carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, sunflower wax, candelilla wax, rose wax, candelilla wax, rose wax, and the like. Among these, from the viewpoint of further enhancing the slow solubility, carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, and sunflower wax are preferable, carnauba wax, rice wax, and hardened oil are more preferable, and carnauba wax is even more preferable. The (b1) component may be used alone or in combination of two or more. When combining two or more, it is preferable to use at least carnauba wax.

[0056] As carnauba wax, known ones can be used. For example, those obtained by purifying natural crude wax by methods such as degumming treatment, deacidification treatment, hydrogenation method, fractionation method, column treatment, etc., or unpurified ones can be mentioned. As rice wax, known ones can be used. For example, those separated when purifying rice oil extracted from rice bran can be mentioned. As hardened oil, known ones can be used. For example, hardened castor oil, hardened palm oil, hardened rapeseed oil, etc. can be mentioned. As sucrose fatty acid ester, known ones can be used. For example, sucrose oleic acid ester, sucrose caprylic acid ester, sucrose capric acid ester, sucrose lauric acid ester, sucrose stearic acid ester, sucrose palmitic acid ester, sucrose myristic acid ester, etc. can be mentioned. As sunflower wax, known ones can be used. For example, those obtained from sunflower seeds can be mentioned.

[0057] (b2) components include, for example, magnesium stearate, calcium stearate, sodium stearyl fumarate, light anhydrous silicic acid, polyethylene glycol, sodium lauryl sulfate, etc. Among these, from the viewpoint of further enhancing the fluidity and compressibility (the degree of compression during compression molding) of the mixed powder and reducing the adhesion to the punch of the tableting machine to further improve productivity, magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid are preferred, magnesium stearate and calcium stearate are more preferred, and magnesium stearate is even more preferred. (b2) component may be used alone or in combination of two or more.

[0058] As the particle group (B), from the viewpoint of further enhancing the slow solubility, it preferably contains one or more selected from the (b1) components, and more preferably contains one or more selected from carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, and sunflower wax. As the particle group (B), two or more may be selected from the (b1) components and used, two or more may be selected from the (b2) components and used, or one or more may be selected from the (b1) components and the (b2) components and used respectively. In particular, it is preferable to select and use two or more from the (b1) components, or to select and use one or more from the (b1) components and the (b2) components respectively, and it is more preferable to select and use one or more from the (b1) components and the (b2) components respectively. When two or more are selected from the (b1) components and used, it is preferable to use at least one of carnauba wax.

[0059] That is, the particle group (B) preferably contains the (b1) component and the (b2) component, and more preferably contains one or more selected from carnauba wax, rice wax, hardened oil, sucrose fatty acid ester, and sunflower wax, and one or more selected from magnesium stearate, calcium stearate, sodium stearyl fumarate, and light anhydrous silicic acid. As another aspect, the particle group (B) preferably contains carnauba wax and a component (B-1) other than carnauba wax, more preferably contains carnauba wax and at least one of rice wax and hydrogenated oil, and even more preferably contains carnauba wax and hydrogenated oil.

[0060] The content of the particle group (B) is preferably 1 to 40% by mass, more preferably 10 to 30% by mass, and even more preferably 15 to 25% by mass based on the total mass of the tablet composition. If the content of the particle group (B) is at least the above lower limit value, the fluidity of the mixed powder can be further enhanced. If the content of the particle group (B) is at most the above upper limit value, the slow solubility can be further enhanced.

[0061] When the particle group (B) contains the component (b1), the content of the component (b1) is preferably 5 to 40% by mass, more preferably 10 to 30% by mass, and even more preferably 15 to 25% by mass based on the total mass of the tablet composition. If the content of the component (b1) is at least the above lower limit value, the slow solubility of the tablet composition is further improved. If the content of the component (b1) is at most the above upper limit value, the slow solubility can be further enhanced.

[0062] When the particle group (B) contains the component (b2), the content of the component (b2) is preferably 0.1 to 5% by mass, more preferably 0.3 to 4% by mass, and even more preferably 1 to 3% by mass based on the total mass of the tablet composition. If the content of the component (b2) is at least the above lower limit value, the compression moldability (tabletability) is further improved, and the tablet composition can be produced with higher productivity. If the content of the component (b2) is at most the above upper limit value, the slow solubility can be further enhanced.

[0063] When the particle group (B) contains both the component (b1) and the component (b2), the mass ratio of the component (b2) to the component (b1) (b2 / b1 ratio) is preferably 0.01 to 0.5, and more preferably 0.05 to 0.3. When the b2 / b1 ratio is at least the above lower limit value, the hardness of the tablet composition can be further enhanced. When the b2 / b1 ratio is at most the above upper limit value, the slow solubility can be further enhanced.

[0064] The total amount of particle group (A) and particle group (B) (AB amount) is preferably 40 to 80% by mass, more preferably 45 to 75% by mass, and even more preferably 50 to 70% by mass with respect to the total mass of the tablet composition. If the AB amount is within the above range, the sustained solubility can be further enhanced.

[0065] The average particle diameter of particle group (B) is preferably 50 to 500 μm, and more preferably 100 to 400 μm.

[0066] ≪Particle group (C)≫ Particle group (C) is a group of one or more kinds of particles selected from monosaccharides (including sugar alcohols), disaccharides, and oligosaccharides. By containing the component (C), the tablet composition can provide appropriate sustained solubility.

[0067] Examples of the monosaccharides constituting particle group (C) include xylose, galactose, glucose, fructose, mannitol, and the like. Examples of the disaccharides containing particle group (C) include lactose, sucrose, maltose, and trehalose. Examples of the oligosaccharides constituting particle group (C) include oligosaccharides of 3 to 10 sugars such as fructooligosaccharide, galactooligosaccharide, raffinose, and lactulose. Among these, from the viewpoint of further enhancing the sustained solubility, mannitol, lactose, sucrose, and oligosaccharides are preferred, mannitol and lactose are more preferred, and mannitol is particularly preferred. These particle groups (C) may be granulated products or may not be granulated products. The sugars constituting particle group (C) may be single species or a combination of two or more species.

[0068] The content of particle group (C) is preferably 10 to 70% by mass, more preferably 20 to 60% by mass, and even more preferably 25 to 50% by mass with respect to the total mass of the tablet composition. If the content of particle group (C) is within the above range, the sustained solubility can be further enhanced.

[0069] The total content (ABC content) of the particle group (A), the particle group (B), and the particle group (C) is preferably 10 to 100% by mass, more preferably 50 to 90% by mass, and even more preferably 60 to 85% by mass with respect to the total mass of the tablet composition. If the ABC content is at least the above lower limit value, the slow solubility can be further enhanced. If the ABC content is at most the above upper limit value, a mixed powder with more excellent tableting properties can be obtained.

[0070] The mass ratio of the particle group (A) to the particle group (C) (A / C ratio) is preferably 0.5 to 3.0, more preferably 0.7 to 2.8, even more preferably 1.0 to 2.5, and particularly preferably 1.5 to 2.0. If the A / C ratio is at least the above lower limit value, the hardness of the tablet composition is further increased. Therefore, when the tablet composition is used for a washing treatment or a dishwashing treatment, it is less likely to break. In particular, it is possible to prevent the tablet composition from breaking during washing and small pieces from popping out of a washing ball or the like and adhering to a textile product. If the A / C ratio is at most the above upper limit value, the tablet composition elutes moderately when in contact with water, and the slow solubility is further improved.

[0071] The mass ratio represented by the component (B) / the component (C) (hereinafter, also referred to as "B / C ratio") is preferably 0.2 to 1.5, more preferably 0.3 to 1.3, even more preferably 0.4 to 1.0, and particularly preferably 0.4 to 0.7. If the B / C ratio is at least the above lower limit value, the tablet composition is less likely to dissolve excessively when in contact with water, and the slow solubility can be maintained well. In addition, when the tablet composition is used for a washing treatment, the slow-dissolving component is less likely to remain undissolved, and the adhesion of the undissolved residue to the textile product after the washing treatment can be prevented. If the B / C ratio is at most the above upper limit value, the tablet composition dissolves moderately easily when in contact with water, and the slow solubility is improved.

[0072] The mass ratio of particle group (B) to particle group (C) (B / C ratio) is 0.2 to 1.5, preferably 0.3 to 1.3, more preferably 0.4 to 1.0, and even more preferably 0.4 to 0.7. If the B / C ratio is at least the above lower limit, when the tablet composition comes into contact with water, excessive dissolution can be suppressed, and sustained solubility can be maintained well. In addition, when the tablet composition is used for a washing treatment, the sustained-release component is less likely to remain undissolved, and adhesion of the undissolved residue to the textile product after the washing treatment can be prevented. If the B / C ratio is at most the above upper limit, when the tablet composition comes into contact with water, it becomes moderately soluble, and the sustained solubility is improved.

[0073] The mass ratio (A / BC ratio) represented by component (A) / ((B) component + (C) component) is preferably 0.2 to 8, more preferably 0.4 to 6, even more preferably 0.6 to 4, and particularly preferably 0.7 to 2. If the A / BC ratio is within the above range, the sustained solubility can be further enhanced.

[0074] The average particle diameter of particle group (C) is preferably 1 to 300 μm, and more preferably 50 to 250 μm.

[0075] ≪Optional Component≫ The tablet composition may contain an optional component (composition optional component) other than particle group (A) and particle group (B). Examples of the composition optional component include a surfactant, a colorant, a thickener, a viscosity reducer, a solubilizer, an alkali agent, an antioxidant, a preservative, a storage stability improver, a pearlescent agent, an extract, etc. These optional components are known substances, are easily available on the market, and can also be prepared. The optional component may be used alone or in combination of two or more. The content of the optional component is not particularly limited as long as the blending purpose can be achieved. For example, it is preferably less than 10% by mass, and more preferably less than 5% by mass based on the total mass of the tablet composition. Note that the total amount of all components constituting the tablet composition is 100% by mass and does not exceed 100% by mass.

[0076] As the surfactant, an anionic surfactant, a nonionic surfactant, a nonionic surfactant, an amphoteric surfactant, a semi-polar surfactant, etc. can be appropriately selected in consideration of the use of the tablet composition.

[0077] (Method for producing a tablet composition) The method for producing a tablet composition includes a step of obtaining a particle group (A), a step of mixing the particle group (A) and the particle group (B) to form a mixed powder, and a step of pressure-molding the mixed powder into an arbitrary shape. Hereinafter, an example of the method for producing a tablet composition will be described. As shown in FIG. 4, the method for producing a tablet composition includes a first mixing step 110, a second mixing step 120, and a molding step 10.

[0078] <First mixing step> The first mixing step 110 is a step of mixing the component (a1) and the component (a2) to form a particle group (A). By the first mixing step 110, a part or all of the raw material (a1 raw material) containing the component (a1) is impregnated into the component (a2), and the particle group (A) of particles in which the component (a1) is supported on the component (a2) is formed.

[0079] The a1 raw material compounded in the first mixing step 110 is a liquid. In the first mixing step 110, the mass ratio of the a1 raw material to the component (a2) (a1 raw material / a2 ratio) can be determined in consideration of the dosage form (liquid, solid, etc.) of the a1 raw material, the type and amount of the dispersion medium contained in the a1 raw material, etc. For example, 0.02 to 1 is preferable, and 0.1 to 0.9 is more preferable. When the a1 raw material / a2 ratio is within the above range, the effect of suppressing aggregation and solidification can be further enhanced.

[0080] Examples of the mixing device used in the first mixing step 110 include high-speed mixers such as Earth Technica and Fukae Powtec. In the first mixing step 110, the mixing method may be, for example, charging component (a2) while stirring the a1 raw material, or charging the a1 raw material while stirring component (a2), or charging the a1 raw material and component (a2) into a stirring device and stirring them. From the viewpoint of better preventing the formation of lumps of the particle group (A), the method of charging the a1 raw material while stirring component (a2) is preferred.

[0081] When the particle group (A) contains an arbitrary component of A particles, the arbitrary component of A particles may be charged into the stirring device together with the a1 raw material in the first mixing step 110, or may be charged into the stirring device together with component (a2).

[0082] The mixing time in the first mixing step 110 is preferably, for example, 1 to 5 minutes, more preferably 1 to 3 minutes. When the mixing time is equal to or longer than the above lower limit value, more of the a1 raw material can be impregnated into component (a2), and the loading amount of component (a1) with respect to component (a2) can be increased. If the mixing time is equal to or shorter than the above upper limit value, the productivity of the tablet composition can be increased.

[0083] The first mixing step 110 may have a drying operation. By having a drying operation, the fluidity of the particle group (A) can be increased. However, if the particle group (A) has physical properties that do not interfere with the subsequent second mixing step, the first mixing step 110 does not require a drying operation.

[0084] <Second mixing step> In the second mixing step 120, the particle group (A) and the particle group (B) are mixed to obtain a mixed powder.

[0085] The mixing device used in the second mixing step 120 is the same as the mixing device used in the first mixing step 110. The mixing device used in the second mixing step 120 may be the same as or different from the mixing device used in the first mixing step 110. In the second mixing step 120, the mixing method may be, for example, charging the particle group (B) while stirring the particle group (A), or charging the particle group (A) while stirring the particle group (B), or charging the particle group (A) and the particle group (B) into a stirring device and stirring them.

[0086] When the tablet composition contains optional components, the optional components may be charged into the stirring device together with the particle group (A) in the second mixing step 120, or may be charged into the stirring device together with the particle group (B).

[0087] The mixing time in the second mixing step 120 is preferably, for example, 1 to 5 minutes, more preferably 2 to 4 minutes. When the mixing time is at least the above lower limit value, the particle group (A) and the particle group (B) can be mixed more uniformly. If the mixing time is at most the above upper limit value, the productivity of the tablet composition can be further enhanced.

[0088] The second mixing step 120 may have a classification operation. By having the classification operation, lumps in the mixed powder can be more reliably removed.

[0089] <Tableting step> In the tableting step, the mixed powder is compression-molded into an arbitrary shape to obtain a tablet composition. Examples of the method of compression molding include a method using a tableting device (tableting method). As the tableting method, for example, tableting (compression molding) is performed using a tableting machine having a mortar and a pestle. Examples of the tableting machine include the single-shot tableting machine (CRUX033L) of Kikusui Seisakusho Co., Ltd. The tableting conditions are not particularly limited, but the tableting pressure is preferably 10 to 100 kN, more preferably 20 to 80 kN.

[0090] <Usage method> The tablet composition of the present invention can be used as it is or can be used after being contained in a container, utensil, or bag. For example, when the tablet composition of the present invention is used for laundry treatment, the tablet composition can be put inside commercially available laundry supplies such as a laundry ball or a laundry net, and these can be put into a washing machine together with the items to be washed for use in washing. As the laundry ball, for example, the outer container part of the product named "Eco Laundry Ball" manufactured by Ihara Kikuhan Co., Ltd. from which the tourmaline inside has been removed can be used. As the laundry net, for example, the product named "Umi. Laundry Net" manufactured by Diyouth can be used. When all or almost all of the tablet composition of the present invention has dissolved during washing in these laundry supplies, they can be reused by separately containing and using the tablet composition of the present invention. The laundry supplies such as a laundry ball or a laundry net containing the tablet composition of the present invention may be put into the washing machine in advance, or may be put on top of the items to be washed after the items to be washed are put in. They may be put into the washing machine during all the steps of water injection, washing, drainage, rinsing, dehydration, and (depending on the washing machine) drying. After the washing is completed, when taking out the items to be washed from the washing machine, the laundry supplies such as a laundry ball or a laundry net containing the tablet composition of the present invention may be left as they are in the washing machine and can be used as they are for the next washing. When the tablet composition of the present invention is used for dishwashing treatment, it can be used in the same manner as when used for laundry treatment.

[0091] In the case of laundry treatment, examples of the items to be washed include fibrous products such as clothing (fabrics), dishcloths, towels, sheets, curtains, etc. The material of the fibrous products is not particularly limited and can be any of natural fibers such as cotton, silk, wool, and chemical fibers such as polyester and polyamide. In the case of dishwashing treatment, examples of the items to be washed include utensils directly used for meals such as plates, chopsticks, spoons, etc.; cooking utensils such as pots and kitchen knives, etc. In this specification, these are also collectively referred to as "tableware".

[0092] (Use) As described above, the tablet composition of the present invention can be used together with an object to be washed, which is a target for cleaning, during a washing process by a washing machine or a dishwashing process by a dishwasher. That is, the tablet composition is suitable for use in a washing process or a dishwashing process.

Examples

[0093] Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited by the following description.

[0094] (Raw materials used) <Particle group (A)> ≪Component (a1)≫ · Dichlorosan: A dispersion containing 70% by mass of polypropylene glycol, trade name "Chinosan HP100", manufactured by BASF. · Benzalkonium chloride: A dispersion containing 50% by mass of water, trade name "Barquat Ms100", manufactured by Lonza. · Zinc ricinoleate: A dispersion containing an organic solvent such as propylene glycol, trade name "TEGO Sorb", manufactured by Evonic. · Alkyltrimethylammonium salt: A dispersion containing water, trade name "Lipocard C12-37W", manufactured by Lion Specialty Chemicals. ≪Component (a2)≫ · Magnesium aluminosilicate: Trade name "Neusilin A", average particle diameter 120 μm, specific surface area 300 m 2 / g, manufactured by Fuji Chemical Industry Co., Ltd. · Silica anhydride: Trade name "Silicia 350", average particle diameter 3.9 μm, specific surface area 300 m 2 / g, manufactured by Fuji Silysia Chemical Ltd. · Synthetic zeolite: Trade name "Zeolam", average particle diameter 140 μm, specific surface area 400 m 2 / g, manufactured by Tosoh Corporation.

[0095] <Particle group (B)> ≪Component (b1)≫ · Carnauba wax: Manufactured by Toagosei Co., Ltd., melting point 85 °C, average particle diameter 14 μm, an oily lubricant. · Hydrogenated oil: Castor oil manufactured by Freund Industry Co., Ltd., melting point 85°C, average particle size 22 μm, oily lubricant. · Rice wax: Manufactured by Toa Gosei Chemical Industry Co., Ltd., melting point 80°C, average particle size 80 μm, oily lubricant. · Sunflower wax: Manufactured by Toa Gosei Chemical Industry Co., Ltd., melting point 78°C, average particle size 80 μm, oily lubricant. ≪Component (b2)≫ · Magnesium stearate: Manufactured by Taihei Chemical Industry Co., Ltd., melting point 140°C, inorganic metal salt-based lubricant.

[0096] <Particle group (C)> ≪Monosaccharide≫ · Mannitol: Manufactured by Freund Industry Co., Ltd., average particle size 200 μm. ≪Disaccharide≫ · Lactose: Manufactured by Freund Industry Co., Ltd., average particle size 140 μm. · Sucrose: Manufactured by Fujifilm Wako Pure Chemical Corporation, average particle size 300 μm. ≪Oligosaccharide≫ · Oligosaccharide (cyclodextrin): Manufactured by Fujifilm Wako Pure Chemical Corporation, average particle size 100 μm.

[0097] (Evaluation method) <Evaluation of slow solubility> Two tablets of the tablet composition were placed in a protective container (the outer container part of the product named "Eco Washing Ball" manufactured by Ihara Enterprise Sales Co., Ltd. with the tourmaline inside removed). The protective container containing the tablet composition was placed in a drum-type washing and drying machine (manufactured by Panasonic Holdings Corporation, product name "NA-VX7600L"), and washed for about 40 minutes in the standard course (from water injection to dehydration, water temperature 15°C). The weight change of the tablet composition before and after washing (weight before washing - weight after washing) was taken as the slow dissolution amount. The same evaluation was carried out 5 times in total, and the average slow dissolution amount per 10 g of the tablet composition was calculated from the 5 slow dissolution amounts, and the slow solubility was evaluated based on the following evaluation criteria. ≪Evaluation criteria≫ ◎: The average slow dissolution amount is 0.8 g or more and less than 2.0 g. 〇: The average slow dissolution amount is 0.5 g or more and less than 0.8 g, or 2.0 g or more and 2.5 g or less. △: The average slow dissolution amount is 0.2 g or more and less than 0.5 g, or more than 2.5 g and less than 5.0 g. ×: The average slow dissolution amount is less than 0.2 g or 5.0 g or more.

[0098] <Agglomeration and solidification> Immediately after the second mixing step of each example, the presence of lumps in the mixed powder was visually confirmed. The results were evaluated based on the following evaluation criteria.

[0099] ≪Evaluation criteria≫ ○: The powder is not sticky and is smooth. △: Lumps are formed in part of the powder and it is sticky. ×: The powder has formed lumps or has become dumpling-like.

[0100] (Examples 1 to 15, Comparative Examples 1, 2, 4) According to the compositions in Tables 1 to 3, the (a2) component was placed in a high-speed mixer (Fukae Powtec B243), and while stirring at a rotational speed of 300 rpm, the a1 raw material was dropped to obtain particle group (A) (the first mixing step). Particle group (B) was added to particle group (A) and stirred, and then particle group (C) was added and stirred to obtain a mixed powder (the second mixing step). The mixed powder was tableted by a tableting machine (manufactured by Fuji Pharmaceutical Machinery Co., Ltd., FY-TPF-100S) at a tableting pressure of 50 kN to obtain columnar tablets (Sumitomo angled flat tablets, diameter 30 mm, height 15 mm, 12 g) for each example. For the obtained tablets, the slow solubility and agglomeration and solidification were evaluated, and the results are shown in the table. In the table, "-" indicates that the component is not formulated. In addition, in the table, the manufacturing method of this example was described as "1".

[0101] (Comparative Example 3) The tablets of this example were obtained in the same manner as in Example 1, except that the (a1) component, (a2) component, particle group (B) and particle group (C) were charged into a high-speed mixer and stirred to obtain a mixed powder. For the obtained tablets, the slow solubility and agglomeration and solidification were evaluated, and the results are shown in the table. In addition, in the table, the manufacturing method of this example was described as "2".

[0102]

Table 1

[0103]

Table 2

[0104]

Table 3

[0105] As shown in Tables 1 and 2, in Examples 1 to 15, the evaluation of sustained solubility was from “△” to “◎”, and the evaluation of aggregation and solidification was “△” or “○”. In Comparative Example 1 which does not contain (a2) and Comparative Example 3 manufactured by Production Method 2, the evaluations of sustained solubility and aggregation and solidification were “×”. In Comparative Example 3 which contains only the (b2) component, the sustained solubility was “×”. In Comparative Example 4 which contains only the (b1) component, it was impossible to make tablets.

Explanation of Reference Signs

[0106] 10, 20, 30 Sustained Solubility Tablet Composition 110 First Mixing Step 120 Second Mixing Step 130 Third Mixing Step

Claims

1. A particle group (A) of a carrier in which an active ingredient (a1) is supported on a carrier (a2), A particle group (B) composed of particles of two or more kinds of lubricants, comprising, wherein the component (a2) is at least one kind of particle selected from zeolite, magnesium aluminosilicate, and anhydrous silicic acid, and is a sustained-release tablet composition.

2. The sustained-release tablet composition according to claim 1, wherein the mass ratio (a1 / a2 ratio) of the component (a1) to the component (a2) is less than 1.

1.

3. Further comprising one or more particle groups (C) selected from monosaccharides, disaccharides, and oligosaccharides, the sustained-release tablet composition according to claim 1.

4. A method for producing a sustained-release tablet composition, comprising a particle group (A) of a carrier in which an active ingredient (a2) is supported on a carrier (a1), and a particle group (B) composed of particles of two or more kinds of lubricants, a step of mixing the component (a1) and the component (a2) to obtain the particle group (A); a step of mixing the particle group (A) and the particle group (B) to obtain a mixed powder; a step of pressure-molding the mixed powder into an arbitrary shape; having, a method for producing a sustained-release tablet composition.

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