Foamable external preparation for skin

Abstract

To provide a carbon dioxide gas foamable external preparation for skin capable of efficiently exerting skin condition improvement effect by a specific active ingredient.SOLUTION: A carbon dioxide gas foamable external preparation for skin of the present invention is a carbon dioxide gas foamable external preparation for skin containing an acid substance, a carbon dioxide gas generating substance which reacts with the acid substance to generate carbon dioxide gas, and thickener, in the same agent or 2 or more agents, and furthermore contains ascorbic acid glucoside or the like (note that in the case where the carbon dioxide gas foamable external preparation for skin consists of 1 agent, it should be mixed with a water-containing substance when in use, and in the case where the carbon dioxide gas foamable external preparation for skin consists of 2 or more agents, any agent should contain water). It is preferable that the carbon dioxide gas foamable external preparation for skin furthermore contain polyhydric alcohol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a foaming topical skin preparation.

Background Art

[0002] Conventionally, topical skin preparations containing synthetic or natural extracts having a blood circulation promoting effect on the skin have been used.

[0003] Since these extracts have insufficient effects when formulated in small amounts and cause excessive irritation to the skin when formulated in large amounts, proposals have been made for topical skin preparations containing carbon dioxide gas to enhance the blood circulation promoting effect. Most of these generate carbon dioxide gas by the reaction of an acidic substance and a carbon dioxide generating substance. In carbon dioxide gas foaming topical skin preparations, components that have been conventionally considered effective, such as extracts of pine bark, are formulated (see Patent Document 1). On the other hand, it has long been known that carbon dioxide gas has a blood circulation promoting effect. For example, a warming pack cosmetic containing a heat generating substance is known (see Patent Document 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, the effects exhibited by plant extracts such as pine bark extract may be low. Further, in terms of improving skin conditions such as lightening the skin color, increasing the skin moisture content, reducing the water evaporation amount, and improving skin elasticity, the development of a more effective carbon dioxide gas foaming topical skin preparation has been desired. In addition, in conventional pack agents containing carbon dioxide gas, although studies have been conducted on the foaming property of carbon dioxide gas, the persistence of bubbles, physical irritation, etc., the study on the effect of improving the skin condition by carbon dioxide gas is not yet sufficient, and the usability, stability, and the feeling of use after washing of the product have not been sufficiently studied either.

[0006] Therefore, in the present invention, by adding a new component to the carbon dioxide gas foaming topical skin preparation, various studies were conducted on active ingredients that can improve the skin condition, are excellent in usability, safety, and stability, have a good feeling of use after washing, and can further enhance the effects of carbon dioxide gas and the like. As a result, by adding a specific active ingredient to various carbon dioxide gas foaming topical skin preparations, it was found that the effects of carbon dioxide gas can be enhanced and the above problems can be solved, and the present invention has been completed.

Means for Solving the Problems

[0007] The present invention relates to a carbon dioxide gas-foaming topical skin preparation containing an acidic substance, a carbon dioxide gas-generating substance that reacts with the acidic substance to generate carbon dioxide gas, and a thickener in the same agent or two or more agents, and further contains at least one selected from glucosyl ascorbate, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-panthenyl alcohol, panthenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate (however, when the carbon dioxide gas-foaming topical skin preparation consists of one agent, it is to be mixed with a hydrous substance during use, and when it consists of two or more agents, one of the agents contains water) (hereinafter simply referred to as "topical skin preparation").

[0008] The present invention also provides a carbon dioxide gas-foaming topical skin preparation (hereinafter simply referred to as "kit for topical skin preparation" or "kit") which is a two-agent type kit according to any one of the following (1) to (3). In each of the following kits, the first agent and the second agent are mixed during use. (1) A first agent which is an acid-containing composition containing an acidic substance and water, and A second agent which is a base-containing composition containing a carbon dioxide-generating substance that reacts with the acidic substance to generate carbon dioxide, wherein the first agent and / or the second agent contains a thickener, and further, the first agent and / or the second agent contains at least one selected from glucosyl ascorbate, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate. (2) A first agent which is an acid-containing composition containing an acidic substance, A second agent which is a base-containing composition containing a carbon dioxide-generating substance that reacts with the acidic substance to generate carbon dioxide and water, wherein the first agent and / or the second agent contains a thickener, and further, the first agent and / or the second agent contains at least one selected from glucosyl ascorbate, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate. (3) A first agent which is an acid- and base-containing composition containing an acidic substance and a carbon dioxide-generating substance that reacts with the acidic substance to generate carbon dioxide, It has a second agent which is a composition containing water, and the first agent and / or the second agent contains a thickening agent. Furthermore, the first agent and / or the second agent contains at least one selected from glucosyl ascorbic acid, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, L-ascorbyl magnesium phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate.

[0009] The present invention also provides a carbon dioxide foaming topical skin preparation (hereinafter simply referred to as "topical skin preparation composition" or "composition") which is a one-agent type composition to be mixed with a hydrous substance during use. Composition: It contains an acidic substance, a carbonate, and a thickening agent, and further contains at least one selected from glucosyl ascorbic acid, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, L-ascorbyl magnesium phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate.

Effects of the Invention

[0010] According to the present invention, by blending a specific active ingredient, the effect of carbon dioxide gas is enhanced, so that it has effects such as whitening the skin color, increasing the water content of the skin, reducing the amount of water evaporation, improving skin elasticity, etc., improving the skin condition, and being excellent in usability, safety, stability such as ease of mixing and ease of application, having a good feeling of use after being washed away, and being able to further enhance the effect of carbon dioxide gas, etc. Furthermore, in addition to improving the state of stratum corneum cells or / and promoting skin turnover, it is excellent in activating skin cells, and has new effects such as making pores of the skin smaller and making the texture smoother. A carbon dioxide foaming topical skin preparation, and a kit and composition for obtaining the topical skin preparation can be provided.

Brief Description of Drawings

[0011]

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Embodiments for Carrying Out the Invention

[0012] Hereinafter, the topical skin preparation, the kit for topical skin preparation, and the composition for topical skin preparation of the present invention will be described based on their preferred embodiments. The kit for topical skin preparation and the composition for topical skin preparation of the present invention are each a form of the foaming topical skin preparation of the present invention. The foaming topical skin preparation of the present invention may contain all of an acidic substance, a carbon dioxide gas generating substance, a thickener, and the following specific component in the same agent, or may be contained in a plurality of agents. When divided into a plurality of agents, the four components may be divided in any manner. However, it is assumed that the acidic substance, the carbon dioxide gas generating substance, and the amount of water necessary for generating carbon dioxide gas are not contained in the same agent. The water content of the same agent containing the acidic substance and the carbon dioxide gas generating substance is preferably 15% by mass or less, more preferably 10% by mass or less, and particularly preferably 8% by mass or less.

[0013] The carbon dioxide gas-foaming topical skin preparation according to the present invention can be used in any form of cosmetics, quasi-drugs, and pharmaceuticals. However, from the viewpoints of effectiveness and usability, it is preferably used as cosmetics or quasi-drugs (medicated cosmetics), and particularly preferably used as quasi-drugs (medicated cosmetics).

[0014] In addition, the carbon dioxide gas-foaming topical skin preparation according to the present invention can be topically applied to the skin including the scalp and hair, and can be used in various forms such as pack agents, hair tonics, facial cleansers, cleansing agents, lotions, emulsions, beauty gels, shampoos, conditioners, etc. When it is to be rinsed off, it is preferably used for pack agents, facial cleansers, and cleansing agents.

[0015] First, each main constituent component used in the topical skin preparation, the kit for topical skin preparation, and the composition for topical skin preparation of the present invention will be described. Hereinafter, in the case of the "topical skin preparation", it may refer to the topical skin preparation before the carbon dioxide gas-generating substance, the acidic substance, and water come into contact with each other and these three are mixed (for example, the kit for topical skin preparation, the composition for topical skin preparation), or it may refer to the carbon dioxide gas-containing topical skin preparation after they are mixed (for example, the one obtained by mixing the two agents of the kit or the one obtained by mixing the composition for topical skin preparation with a hydrous substance). Which one it refers to is determined according to the context. Hereinafter, the components and the like contained in the topical skin preparation, the kit, and the composition of the present invention are collectively described.

[0016] <Acidic substance> As the acidic substance used in the present invention, either an inorganic acid or an organic acid may be used, and one or more of these are used.

[0017] Examples of the inorganic acid include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, potassium acid pyrophosphate, sulfamic acid, and the like.

[0018] Examples of the organic acid include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid or salts thereof, dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid or salts thereof, acidic amino acids such as glutamic acid and aspartic acid or salts thereof, oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α - oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid or salts thereof, etc. Examples of the inorganic acid include inorganic acids such as phosphoric acid and sulfurous acid or salts thereof. One or more of these can be used.

[0019] Among them, from the viewpoints of safety and solubility in water, citric acid, ascorbic acid, malic acid, and succinic acid are preferred.

[0020] From the viewpoint of efficiently expressing the beauty effect, the content of the acidic substance in the external preparation for skin of the present invention is preferably 0.01 part by mass or more and 30 parts by mass or less, and more preferably 0.05 part by mass or more and 20 parts by mass or less, based on 100 parts by mass of the external preparation for skin. Similarly, the content of the acidic substance in the acid-containing composition of the kit of (1) and (2) and the content of the acidic substance in the acid- and base-containing composition of the kit of (3) are preferably 0.01 part by mass or more and 30 parts by mass or less, and more preferably 0.05 part by mass or more and 20 parts by mass or less, based on 100 parts by mass of the total amount of the two agents of the corresponding kit. The amount of the external preparation for skin as referred to in this specification, in the case where the external preparation for skin of the present invention is a kit of two or more agents, may be the total amount of each agent of the kit at the start point of mixing the components of each kit, and in the case where the external preparation for skin is obtained by mixing a one-agent type composition for external preparation for skin and a hydrous substance, it may be the total amount of the composition and the hydrous substance at the start point of this mixing.

[0021] Furthermore, the content of the acidic substance in the acid-containing composition (acid-containing hydrous composition) in the kit of (1) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less, in the acid-containing composition (acid-containing hydrous composition). In the acid-containing composition in the kit of (2) of the present invention, the content of the acidic substance is preferably 0.1% by mass or more and 90% by mass or less, more preferably 0.5% by mass or more and 80% by mass or less, based on the solid content of the acid-containing composition. In the acid and base-containing composition in the kit of (3) of the present invention, the content of the acidic substance is preferably 0.01% by mass or more and 50% by mass or less, more preferably 0.05% by mass or more and 40% by mass or less, based on the solid content of the acid and base-containing composition. In the composition for external use on skin of the present invention, the content of the acidic substance is preferably 0.01% by mass or more and 40% by mass or less, more preferably 0.05% by mass or more and 30% by mass or less, based on the solid content of the composition for external use on skin.

[0022] <Carbon dioxide generating substance> As the carbon dioxide generating substance that reacts with the acidic substance used in the present invention to generate carbon dioxide gas, any substance that reacts with the acidic substance to generate carbon dioxide may be used.

[0023] Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate; and hydrogen carbonates such as ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate, and calcium hydrogen carbonate. One or more of these may be used. Among these, hydrogen carbonates are preferably used, and sodium hydrogen carbonate is more preferably used in terms of achieving an appropriate foaming power.

[0024] The content of the carbon dioxide generating substance in the external preparation for skin of the present invention is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less, based on 100 parts by mass of the external preparation for skin. Similarly, the content of the carbon dioxide generating substance in the base-containing composition of the kit of (1) and (2) and the content of the carbon dioxide generating substance in the acid and base-containing composition in the kit of (3) are preferably 0.01 part by mass or more and 30 parts by mass or less, more preferably 0.05 part by mass or more and 20 parts by mass or less, based on 100 parts by mass of the total amount of the two agents of the corresponding kit.

[0025] The content of the carbon dioxide generating substance in the base-containing composition in the kit of (1) of the present invention is preferably 0.1% by mass or more and 90% by mass or less, more preferably 0.5% by mass or more and 80% by mass or less, in the solid content of the base-containing composition. The content of the carbon dioxide generating substance in the base-containing composition (aqueous composition) in the kit of (2) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less, in the base-containing composition. The content of the carbon dioxide generating substance in the acid and base-containing composition in the kit of (3) of the present invention is preferably 0.01% by mass or more and 50% by mass or less, more preferably 0.05% by mass or more and 40% by mass or less, in the solid content of the acid and base-containing composition. The content of the carbon dioxide generating substance in the composition for external preparation for skin of the present invention is preferably 0.01% by mass or more and 40% by mass or less, more preferably 0.05% by mass or more and 30% by mass or less, in the solid content of the composition for external preparation for skin.

[0026] <Thickener> Examples of the thickeners used in the present invention include various ones that can be used in the fields of cosmetics and pharmaceuticals. As the thickener, for example, synthetic polymers, semi-synthetic polymers, natural polymers, viscous minerals, etc. can be used. Specifically, as the synthetic polymer, carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylates / acrylic acid alkyl crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethyl cellulose, cationized cellulose, hydrophilic synthetic polymers such as (PEG-240 / decyltetradeceth-20 / HDI) copolymer can be used. As the semi-synthetic polymer, for example, carboxymethyl cellulose or its salts, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, cellulose derivatives such as sulfonated cellulose derivatives can be mentioned. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide, etc. As the natural polymer, polysaccharides and their derivatives, for example, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, alginic acid or its salts, gum arabic, pectin, quince seed, starch, algocolloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acid or its salts, ribonucleic acid or its salts, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, sericin and other water-soluble proteins, hyaluronic acid or its salts, mucopolysaccharides such as chondroitin sulfate can be mentioned. Examples of the clay mineral include laponite, bentonite, smectite kaolinite, montmorillonite, etc. As the above salts, alkali metal salts are preferably mentioned, for example, sodium salts and potassium salts.

[0027] In the present invention, one or more of the above thickeners can be used. Among these thickeners, it is preferable to use those with high solubility or dispersibility in water because it is possible to alleviate the rough feeling of the skin caused by undissolved components or undispersed components during use. Here, the quality of solubility in water can be judged from the fact that when water at about room temperature is added and stirred, it instantly dissolves in water, or disperses and uniformly dissolves to have sufficient viscosity, and no lumps are formed during dissolution or dispersion.

[0028] From the viewpoints of the above-mentioned solubility and dispersibility in water, preferable thickeners include, for example, carboxyvinyl polymer, carboxymethyl cellulose or its salts, polyvinyl alcohol, PEG-240 / decyltetradeceth-20 / HDI copolymer, sodium polyacrylate, acrylic acid / methacrylic acid alkyl copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, cellulose derivatives (celluloses), galactan, gum arabic, tragacanth gum, tamarind gum, agar, mannan, curdlan, alginic acid or its salts, collagen, gelatin, albumin, etc. Particularly preferable ones include alginic acid or its salts, hydroxyethyl ether, carboxymethyl cellulose or its salts, xanthan gum, carrageenan, tamarind gum, albumin.

[0029] The amount of the thickener contained in the skin external preparation of the present invention is preferably 0.01 part by mass or more and 40 parts by mass or less, and more preferably 0.1 part by mass or more and 30 parts by mass or less with respect to 100 parts by mass of the skin external preparation. Similarly, the content of the thickener in the acid-containing composition and / or the base-containing composition in the kit of (1) and (2) and the content of the thickener in the acid and base-containing composition and / or the water-containing composition in the kit of (3) are preferably 0.01 part by mass or more and 40 parts by mass or less, and more preferably 0.1 part by mass or more and 30 parts by mass or less with respect to 100 parts by mass of the total amount of the two agents of the corresponding kit. Here, the amount of the thickener in the acid-containing composition and / or the base-containing composition means the amount when one of them contains the thickener, and the total amount when both contain the thickener. The same applies to the amount of the thickener in the base-containing composition and / or the water-containing composition.

[0030] In addition, the content of the thickener in the composition for skin external preparation of the present invention is preferably 0.1% by mass or more and 40% by mass or less, and more preferably 0.5% by mass or more and 30% by mass or less in the solid content of the composition for skin external preparation.

[0031] <Water> As the water that can be used in the present invention, water that can be used in cosmetics, external pharmaceuticals, quasi-drugs, etc. can be used, but purified water, distilled water, membrane-filtered water, and ion-exchanged water are preferred.

[0032] The amount of water in the external preparation for skin of the present invention (or the amount of water used in the external preparation for skin) is preferably 20 parts by mass or more and 95 parts by mass or less, more preferably 30 parts by mass or more and 90 parts by mass or less, based on 100 parts by mass of the external preparation for skin, from the viewpoint of sufficiently exhibiting the beauty effect according to the present invention. Here, the amount of water refers to the ratio of water to the total of the amount of water and the composition amount in the case of the composition for external preparation for skin. Similarly, the water content in the kits of (1) to (3) is preferably 20 parts by mass or more and 95 parts by mass or less, more preferably 30 parts by mass or more and 90 parts by mass or less, based on 100 parts by mass of the total amount of the two agents of the corresponding kit. The amount of water in the kit here refers to the total amount of water in the two agents, and is the amount of water in the agent when only one of the two agents contains water.

[0033] <Polyhydric alcohol> In the present invention, it is preferable to contain a polyhydric alcohol in the external preparation for skin because a high moisturizing effect can be exhibited by a combination with a specific component described later. Examples of the polyhydric alcohol include polyglycerins such as glycerin, diglycerin, triglycerin, and tetraglycerin; ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, 1,2-pentanediol, sorbitol, polyglycerin derivatives; reducing sugars such as glucose, fructose, glyceraldehyde, lactose, arabinose, and maltose; sugar alcohols such as erythritol, maltitol, sorbitol, and xylitol. These can be used alone or in combination of two or more. Among them, from the viewpoint of high moisturizing effect, the number of carbon atoms is preferably 2 or more, and more preferably 2 or more valences.

[0034] The amount of the polyhydric alcohol contained in the external preparation for skin of the present invention is preferably 1 part by mass or more and 80 parts by mass or less, more preferably 5 parts by mass or more and 70 parts by mass or less, based on 100 parts by mass of the external preparation for skin, from the viewpoint of sufficiently exhibiting the cosmetic effect by the combination with the above-mentioned specific components. Similarly, the content of the polyhydric alcohol in the acid-containing composition and / or the base-containing composition in the kit of (1) and (2) and the content of the polyhydric alcohol in the acid- and base-containing composition and / or the water-containing composition in the kit of (3) are preferably 1 part by mass or more and 80 parts by mass or less, more preferably 5 parts by mass or more and 70 parts by mass or less, based on 100 parts by mass of the total amount of the two agents of the corresponding kit. Here, the amount of the polyhydric alcohol in the acid-containing composition and / or the base-containing composition means the amount when one of them contains the polyhydric alcohol, and the total amount when both contain the polyhydric alcohol. The same applies to the amount of the polyhydric alcohol in the base-containing composition and / or the water-containing composition.

[0035] One of the features of the external preparation for skin of the present invention is that it contains a specific active ingredient (hereinafter also referred to as a specific component). Such components will be described in detail below.

[0036] <Ascorbic acid glucoside> Examples of ascorbic acid glucoside include 2-O-α-D-glucopyranosyl-L-ascorbic acid (which may also be referred to as AA-2G, ascorbic acid 2-glucoside, L-ascorbic acid 2-glucoside, etc.). Ascorbic acid glucoside may be isolated from nature or may be biochemically synthesized. Ascorbic acid glucoside is said to have an effect of suppressing melanin production and is used in cosmetics and quasi-drugs for whitening. The present inventor has found that the effect of this ascorbic acid glucoside is efficiently exhibited in a carbon dioxide gas foaming skin external preparation obtained by mixing with an acidic substance, a carbon dioxide gas generating substance, a thickener, and water. Ascorbic acid glucoside may be contained in any of the kits of (1) to (3), or may be contained in a composition for a skin external preparation in a single-agent form. When ascorbic acid glucoside is contained in a two-agent kit, it may be used in any of the following: an agent in which one of the two agents is in a gel form and the other is in a solid form; an agent in which one of the two agents is in a gel form and the other is in a liquid form; an agent in which both of the two agents are in a gel form; an agent in which one of the two agents is in a liquid form and the other is in a solid form; or an agent in which both of the two agents are in a liquid form. An agent containing various specific components described below including ascorbic acid glucoside may be in a solid form, a liquid form, or a gel form.

[0037] In the present invention, from the viewpoint of efficiently exerting the advantageous effects of glucosyl ascorbate, it is preferable that the amount of glucosyl ascorbate in the external preparation for skin is 0.01% by mass or more and 20% by mass or less. From this viewpoint, the amount of glucosyl ascorbate in the external preparation for skin is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, and particularly preferably 0.1 part by mass or more and 5 parts by mass or less. Similarly, the content of glucosyl ascorbate in the acid-containing composition and / or the base-containing composition in the kit of (1) and (2) and the content of glucosyl ascorbate in the acid- and base-containing composition and / or the water-containing composition in the kit of (3) are preferably 0.01 part by mass or more and 20 parts by mass or less, more preferably 0.05 part by mass or more and 10 parts by mass or less, and particularly preferably 0.1% by mass or more and 5% by mass or less with respect to 100 parts by mass of the total amount of the two agents of the corresponding kit. Here, the amount of glucosyl ascorbate in the acid-containing composition and / or the base-containing composition means the amount when one of them contains glucosyl ascorbate, and the total amount when both contain glucosyl ascorbate. The same applies to the amount of glucosyl ascorbate in the acid- and base-containing composition and / or the water-containing composition.

[0038] When glucosyl ascorbate is contained in the kit of (1), it may be contained in either the acid-containing composition (water-containing composition) or the base-containing composition. When glucosyl ascorbate is contained in the acid-containing composition of the kit of (1), from the viewpoint of efficiently exerting the advantageous effects of glucosyl ascorbate, its content is preferably 0.01% by mass or more and 20% by mass or less in the acid-containing composition, and more preferably 0.05% by mass or more and 10% by mass or less. When glucosyl ascorbate is contained in the base-containing composition of the kit of (1), its content is preferably 0.1% by mass or more and 90% by mass or less in the solid content of the base-containing composition, and more preferably 0.5% by mass or more and 80% by mass or less.

[0039] When ascorbyl glucoside is contained in the kit of (2), it is preferable that it is contained in the acid-containing composition because the effect of ascorbyl glucoside in the external preparation for skin can be efficiently exhibited. On the other hand, when it is contained in the base-containing composition, it is difficult to stably exist in the kit. When ascorbyl glucoside is contained in the acid-containing composition of the kit of (2), its content is preferably 90% by mass or less in the solid content of the acid-containing composition, and more preferably 0.1% by mass or more and 80% by mass or less.

[0040] When ascorbyl glucoside is contained in the kit of (3), it may be contained in any of the acid and carbonate-containing composition and the water-containing composition. When ascorbyl glucoside is contained in the acid and carbonate-containing composition of the kit of (3), its content is preferably 0.1% by mass or more and 50% by mass or less in the solid content of the acid and carbonate-containing composition, and more preferably 0.5% by mass or more and 40% by mass or less. Also, when ascorbyl glucoside is contained in the water-containing composition of the kit of (3), its content is preferably 0.01% by mass or more and 20% by mass or less in the water-containing composition, and more preferably 0.05% by mass or more and 10% by mass or less.

[0041] The content of ascorbyl glucoside in the composition for external preparation for skin of the present invention is preferably 0.1% by mass or more and 30% by mass or less, and more preferably 0.5% by mass or more and 20% by mass or less in the solid content of the composition for external preparation for skin.

[0042] <Another specific component> The skin external preparation, skin external preparation kit, and composition for skin external preparation of the present invention can exhibit effects such as beauty even when containing specific active ingredients other than ascorbyl glucoside. Such ingredients are listed below. The preferred ratio of the specific ingredients contained in the skin external preparation kit of the present invention to the total amount of the two agents is the same as the preferred amount of the specific ingredients in the skin external preparation shown below. Also, the preferred content of the specific ingredients in the composition for skin external preparation is the same as the preferred amount of the specific ingredients in the solid content of the skin external preparation shown below.

[0043] Allantoin is a compound having the composition of C4H6N4O3 and is the diureide of glyoxylic acid. It is also known as 5-ureidohydantoin or glyoxydiu reide and is known as an anti-inflammatory agent. When the skin external preparation contains allantoin, its amount is preferably 0.001% by mass or more and 20% by mass or less, more preferably 0.01% by mass or more and 10% by mass or less in the skin external preparation. Also, the amount of allantoin is preferably 0.01% by mass or more and 30% by mass or less in the solid content of the skin external preparation, more preferably 0.05% by mass or more and 20% by mass or less.

[0044] When allantoin is contained in the acid-containing composition of the kit of (1), its content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less in the acid-containing composition. Also, when allantoin is contained in the base-containing composition of the kit of (1), its content is preferably 0.01% by mass or more and 30% by mass or less in the solid content of the base-containing composition, more preferably 0.05% by mass or more and 20% by mass or less.

[0045] When allantoin is contained in the acid-containing composition of the kit of (2), its content is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less in the solid content of the acid-containing composition. When allantoin is contained in the base-containing composition of the kit of (2), its content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less in the base-containing composition.

[0046] When allantoin is contained in the acid and carbonate-containing composition of the kit of (3), its content is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less in the solid content of the acid and carbonate-containing composition. When allantoin is contained in the water-containing composition of the kit of (3), its content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less in the water-containing composition.

[0047] Tranexamic acid, also called trans-4-(aminomethyl)cyclohexane carboxylic acid, is known as an anti-inflammatory agent and a skin-whitening agent. When a topical skin preparation contains tranexamic acid, the amount is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.1% by mass or more and 10% by mass or less in the topical skin preparation. Also, the amount of tranexamic acid is preferably 0.1% by mass or more and 80% by mass or less, more preferably 1% by mass or more and 70% by mass or less in the solid content of the topical skin preparation.

[0048] When tranexamic acid is contained in the acid-containing composition of the kit of (1), its content is preferably 0.1% by mass or more and 60% by mass or less, more preferably 1% by mass or more and 50% by mass or less in the acid-containing composition. When tranexamic acid is contained in the base-containing composition of the kit of (1), its content is preferably 1% by mass or more and 90% by mass or less, more preferably 5% by mass or more and 80% by mass or less in the solid content of the base-containing composition.

[0049] When tranexamic acid is contained in the acid-containing composition of the kit of (2), its content is preferably 1% by mass or more and 90% by mass or less, more preferably 5% by mass or more and 80% by mass or less in the solid content of the acid-containing composition. When tranexamic acid is contained in the base-containing composition of the kit of (2), its content is preferably 0.1% by mass or more and 60% by mass or less, more preferably 1% by mass or more and 50% by mass or less in the base-containing composition.

[0050] When tranexamic acid is contained in the acid and carbonate-containing composition of the kit of (3), its content is preferably 0.1% by mass or more and 80% by mass or less, more preferably 1% by mass or more and 75% by mass or less in the solid content of the acid and carbonate-containing composition. When tranexamic acid is contained in the water-containing composition of the kit of (3), its content is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.1% by mass or more and 20% by mass or less in the water-containing composition.

[0051] d-Camphor has the chemical name (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one and is one of the bicyclic monoterpene ketones and is contained in camphor trees etc. and obtained by steam distillation of wood chips. When the external preparation for skin contains d-camphor, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the external preparation for skin. Also, the amount of d-camphor is preferably 0.01% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

[0052] Salicylic acid is a compound with the chemical formula C7H6O3. When the external preparation for skin contains salicylic acid, the amount thereof is preferably 0.0001% by mass or more and 10% by mass or less in the external preparation for skin. Also, the amount of salicylic acid is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

[0053] Biotin is called D-[(+)-cis-hexahydro-2-oxo-1H-thieno-(3,4)-imidazole-4-valeric acid] and is a kind of water-soluble vitamin classified in the vitamin B group. When a topical skin preparation contains biotin, the amount thereof is preferably 0.0001% by mass or more and 1% by mass or less in the topical skin preparation. Further, the amount of biotin is preferably 0.0001% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0054] Resorcin is a compound represented by the chemical formula C6H4(OH)2 and corresponds to 1,3-dihydroxybenzene. When a topical skin preparation contains resorcin, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation. Further, the amount of resorcin is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0055] Triclocarbanilide is also referred to as trichlorocarban or 3,4,4’-trichlorocarbanilide. When a topical skin preparation contains triclocarbanilide, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation. Further, the amount of triclocarbanilide is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0056] Triclosan is also referred to as 5-chloro-2-(2’,4’-dichlorophenoxy)phenol. When a topical skin preparation contains triclosan, the amount thereof is preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation. Further, the amount of triclosan is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0057] Benzethonium chloride has the chemical formula C 27 H 42 and is represented by ClNO2 and is a kind of cationic surfactant. When a topical skin preparation contains benzethonium chloride, the amount thereof is preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation. Further, the amount of benzethonium chloride is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0058] Sulfur is a simple substance represented by the chemical formula S. When a topical skin preparation contains sulfur, the amount thereof is preferably 0.001% by mass or more and 20% by mass or less in the topical skin preparation. Also, the amount of sulfur is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0059] Photosensitizer No. 201 is also called peonin. When a topical skin preparation contains Photosensitizer No. 201, the amount thereof is preferably 0.0001% by mass or more and 5% by mass or less in the topical skin preparation. Also, the amount of peonin is preferably 0.0005% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0060] Pyridoxine is a water-soluble compound called 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, or vitamin B6. When a topical skin preparation contains pyridoxine, the amount thereof is preferably 0.0001% by mass or more and 5% by mass or less in the topical skin preparation. Also, the amount of pyridoxine is preferably 0.0005% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0061] Pyridoxine hydrochloride is pyridoxine in the form of hydrochloride and is also called 5-Hydroxy-6-methylpyridine-3,4-dimethanol monohydrochloride. When a topical skin preparation contains pyridoxine hydrochloride, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation. Also, the amount of pyridoxine hydrochloride is preferably 0.01% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0062] Zinc oxide is represented by the chemical formula ZnO. When a topical skin preparation contains zinc oxide, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less in the topical skin preparation. Also, it is preferably 0.05% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0063] Examples of arbutin include β-arbutin and α-arbutin, and β-arbutin, which is called 4-(β-D-glucopyranosyloxy)phenol, is common. When a topical skin preparation contains arbutin, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.1% by mass or more and 10% by mass or less, in the topical skin preparation. Further, the amount of arbutin is preferably 0.1% by mass or more and 50% by mass or less, more preferably 1% by mass or more and 40% by mass or less, in the solid content of the topical skin preparation.

[0064] When arbutin is contained in the acid-containing composition of the kit of (1), the content thereof is preferably 0.1% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 20% by mass or less, in the acid-containing composition. Further, when arbutin is contained in the base-containing composition of the kit of (1), the content thereof is preferably 1% by mass or more and 90% by mass or less, more preferably 5% by mass or more and 85% by mass or less, in the solid content of the base-containing composition.

[0065] When arbutin is contained in the acid-containing composition of the kit of (2), the content thereof is preferably 1% by mass or more and 90% by mass or less, more preferably 5% by mass or more and 85% by mass or less, in the solid content of the acid-containing composition. Further, when arbutin is contained in the base-containing composition of the kit of (2), the content thereof is preferably 0.1% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 20% by mass or less, in the base-containing composition.

[0066] When arbutin is contained in the acid and carbonate-containing composition of the kit of (3), the content thereof is preferably 1% by mass or more and 80% by mass or less, more preferably 5% by mass or more and 70% by mass or less, in the solid content of the acid and carbonate-containing composition. Further, when arbutin is contained in the water-containing composition of the kit of (3), the content thereof is preferably 0.1% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 20% by mass or less, in the water-containing composition.

[0067] L-Ascorbyl magnesium phosphate is also known as magnesium L-ascorbic acid-2-phosphate. When a topical skin preparation contains magnesium L-ascorbic acid-2-phosphate, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less in the topical skin preparation, and preferably 0.05% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0068] Ascorbyl dipalmitate is also known as L-ascorbic acid 2,6-dipalmitate. When a topical skin preparation contains ascorbyl dipalmitate, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less in the topical skin preparation, and preferably 0.05% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0069] Examples of glycyrrhizic acid include β-glycyrrhizic acid. Examples of glycyrrhizic acid derivatives include dipotassium glycyrrhizate (sometimes referred to as "nikalium glycyrrhizate"), monoammonium glycyrrhizate, and stearyl glycyrrhetinate. Monoammonium glycyrrhizate may be an anhydride or a hydrate. When a topical skin preparation contains these glycyrrhizic acids and derivatives thereof, the amount of one of these and the total amount are preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation, and more preferably 0.001% by mass or more and 1% by mass or less. The content of glycyrrhizic acid and derivatives thereof is preferably 0.001% by mass or more and 20% by mass or less in the solid content of the topical skin preparation, and more preferably 0.005% by mass or more and 10% by mass or less.

[0070] When glycyrrhizic acid and derivatives thereof are contained in the acid-containing composition of the kit of (1), the content thereof is preferably 0.001% by mass or more and 10% by mass or less in the acid-containing composition, and more preferably 0.005% by mass or more and 5% by mass or less. When glycyrrhizic acid and derivatives thereof are contained in the base-containing composition of the kit of (1), the content thereof is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the base-containing composition, and more preferably 0.05% by mass or more and 10% by mass or less.

[0071] When glycyrrhizic acid and its derivatives are contained in the acid-containing composition of the kit of (2), the content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid-containing composition. When glycyrrhizic acid and its derivatives are contained in the base-containing composition of the kit of (2), the content is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.005% by mass or more and 5% by mass or less, in the base-containing composition.

[0072] When glycyrrhizic acid and its derivatives are contained in the acid and carbonate-containing composition of the kit of (3), the content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid and carbonate-containing composition. When glycyrrhizic acid and its derivatives are contained in the water-containing composition of the kit of (3), the content is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.050% by mass or more and 5% by mass or less, in the water-containing composition.

[0073] Each of the above preferred amounts regarding the amount of glycyrrhizic acid and its derivatives may be the amount of one of glycyrrhizic acid and its derivatives, or may be the total amount of glycyrrhizic acid and its derivatives.

[0074] Retinol is also called vitamin A. When the external preparation for skin contains retinol, the amount is preferably 0.00001% by mass or more and 20% by mass or less in the external preparation for skin. Also preferably 0.00005% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

[0075] Retinol palmitate is also called vitamin A palmitate. When the external preparation for skin contains retinol palmitate, the amount is preferably 0.00001% by mass or more and 20% by mass or less in the external preparation for skin. Also preferably 0.00005% by mass or more and 10% by mass or less in the solid content of the external preparation for skin.

[0076] Estradiol has the common name estra-1,3,5(10)-triene-3,17β-diol. Ethinyl estradiol has the common name 17-ethinylestra-1,3,5(10)-triene-3β,17β-diol. When a topical skin preparation contains these estradiols, the amount of each type and the total amount are preferably 0.00001% by mass or more and 5% by mass or less in the topical skin preparation. Also, it is preferably 0.00005% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0077] Both dl-α-tocopherol acetate and dl-α-tocopherol nicotinate are known as vitamin E derivatives. When a topical skin preparation contains dl-α-tocopherol acetate and / or dl-α-tocopherol nicotinate, the amount of each type and the total amount are preferably 0.0001% by mass or more and 10% by mass or less in the topical skin preparation. Also, it is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0078] D-panthenyl alcohol is also called (R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide. When a topical skin preparation contains D-panthenyl alcohol, the amount is preferably 0.01% by mass or more and 20% by mass or less in the topical skin preparation. Also, it is preferably 0.05% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0079] Panthenyl ethyl ether is also called (2R)-N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide. When a topical skin preparation contains panthenyl ethyl ether, the amount is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation. Also, it is preferably 0.005% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0080] Phenol has a structural formula of C6H5OH and has a structure in which one of the hydrogen atoms of benzene is substituted with a hydroxyl group. When a topical skin preparation contains phenol, the amount thereof is preferably 0.001% by mass or more and 10% by mass or less in the topical skin preparation. Further, it is preferably 0.005% by mass or more and 10% by mass or less in the solid content of the topical skin preparation.

[0081] Placenta means a general term for growth factors that promote cell division of the placenta of animals, preferably pigs, horses, cows, sheep, humans, other nutrients, nutrients of fish ovarian membranes, and nutritional components of plant embryos. The placenta used in the present invention is not particularly limited as long as it can be usually used as a cosmetic or quasi-drug. In the present invention, commercially available water-soluble extracts and powders can be used. When a topical skin preparation contains placenta, the amount thereof is preferably 0.01% by mass or more and 20% by mass or less in the topical skin preparation. Further, it is preferably 0.05% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0082] Among these specific components, allantoin, dipotassium glycyrrhizinate, stearyl glycyrrhizinate, d-camphor, salicylic acid, arbutin, and placenta are preferably contained in the kit for a two-agent topical skin preparation in the present invention, and particularly preferably contained in the kit of (1) or (2). Needless to say, including these, the specific components may be contained in the composition for a one-agent topical skin preparation or may be contained in the kit for a two-agent topical skin preparation. In particular, it is preferable that the specific components are used in the two-agent kit from the viewpoint of increasing the amount of horny moisture after use or exhibiting an excellent turnover effect. Further, although the skin condition improving effect and the effect of improving the feeling of use of the present invention are not limited by the type of thickener, the desired effects among these can be further enhanced by the type of thickener combined with the specific components.

[0083] For each specific ingredient, it may be used in any of the following preparations: a preparation in which one of the two agents is in gel form and the other is in solid form; a preparation in which one of the two agents is in gel form and the other is in liquid form; a preparation in which both of the two agents are in gel form; a preparation in which one of the two agents is in liquid form and the other is in solid form; or a preparation in which both of the two agents are in liquid form. For dl-α-tocopherol acetate, it is preferably used in a preparation in which one of the two agents is in gel form and the other is in liquid form, a preparation in which both of the two agents are in gel form, a preparation in which one of the two agents is in liquid form and the other is in solid form, or a preparation in which both of the two agents are in liquid form. Furthermore, for placenta, it is preferably used in a preparation in which one of the two agents is in gel form and the other is in solid form, a preparation in which one of the two agents is in gel form and the other is in liquid form, a preparation in which both of the two agents are in gel form, or a preparation in which both of the two agents are in liquid form.

[0084] Also, in the kits of (1) to (3), estradiol, ethinyl estradiol, nicotinic acid dl-α-tocopherol, nicotinic acid dl-α-tocopherol, D-pantothenyl alcohol, pantothenyl ethyl ether, phenol, and placenta are preferably contained in the aqueous compositions (the acid-containing composition of the kit of (1), the base-containing composition of the kit of (2), the aqueous composition of the kit of (3)) in order to exert their effects. The amounts of these specific ingredients (estradiol, ethinyl estradiol, nicotinic acid dl-α-tocopherol, nicotinic acid dl-α-tocopherol, D-pantothenyl alcohol, pantothenyl ethyl ether, phenol, placenta) contained in these aqueous compositions in the kits of (1) to (3) preferably have a preferred ratio in the total amount of the two agents that is the same as the preferred ratio of these specific ingredients in the above-described topical skin preparations.

[0085] For allantoin, glycyrrhizic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzalkonium chloride, sulfur, photosensitizer No. 201, pyridoxines, zinc oxide, arbutin, retinol, and retinol palmitate, it is preferable that they are included in the base-containing composition or acid-containing composition of the kit of (1), the acid-containing composition of the kit of (2), or the acid- and base-containing composition of the kit of (3) in order to exhibit their effects. The amounts of these specific components (allantoin, glycyrrhizic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzalkonium chloride, sulfur, photosensitizer No. 201, pyridoxines, zinc oxide, arbutin, retinol, and retinol palmitate) included in these compositions in the kits of (1) to (3) preferably have the same ratio to the total amount of the two agents as the preferred ratio of these specific components to 100 parts by mass of the above-described external preparation for skin.

[0086] <Other components> The external preparation for skin of the present invention may contain one or more components commonly used in external preparations for skin, such as other active ingredients, preservatives, pH adjusters, oils and fats, fragrances, colorants, antioxidants, antibacterial and antifungal agents, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, inorganic salts, lubricants, solvents, etc. These are contained in the composition for external preparation for skin of the present invention. In the kit of the present invention, the components to be added can be used in either the first agent or the second agent, or can be used in both agents.

[0087] In the external preparation for skin, kit, and composition for external preparation for skin of the present invention, the total content of other components (water, acidic substances, carbon dioxide-generating substances, thickeners, polyhydric alcohols, and components other than the specific components) is preferably 30% by mass or less, and more preferably 25% by mass or less.

[0088] <Dosage form and component amounts of the kit> (1) to (3) kits will be described in further detail. In the kits of (1) to (3), the dosage forms of the aqueous compositions of each kit (the acid-containing composition of the kit of (1), the base-containing composition of the kit of (2), the aqueous composition of the kit of (3)) include gel-like or liquid. Further, as the dosage form of the other agent of each kit (the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), the acid and base-containing composition of the kit of (3)), any dosage form such as solid, liquid, gel-like, etc. may be used. In the case of a solid form, it is preferable to be in the form of granules, fine granules, or powder from the viewpoints of ease of mixing with the other agent and cost during production.

[0089] <The aqueous compositions of the kits of (1) to (3)> The preferable amounts of the carbon dioxide-generating substance, acidic substance, and specific component in the aqueous composition of the kits of (1) to (3) are as described above. Further, the proportion of water in the aqueous composition of the kits of (1) to (3) is preferably 20% by mass or more, particularly 30% by mass or more, from the viewpoint of miscibility with the other agent of each kit, and preferably 95% by mass or less, particularly 90% by mass or less, from the viewpoint of enhancing the cosmetic effect as a topical skin preparation containing other components.

[0090] When the aqueous composition of the kits of (1) to (3) contains a polyhydric alcohol, the proportion of the polyhydric alcohol in the aqueous composition is preferably 1% by mass or more, particularly 10% by mass or more, from the viewpoint of enhancing the moisturizing effect by combination with a specific component, and preferably 90% by mass or less, particularly 80% by mass or less, especially 70% by mass or less, from the viewpoint of enhancing the cosmetic effect as a topical skin preparation containing other components.

[0091] In addition, in each of the aqueous compositions (1) to (2), it is preferable that the above-described acidic substance, carbon dioxide-generating substance, and specific component be contained in the above-described amounts. Further, in each of the aqueous compositions (1) to (3), a humectant other than polyhydric alcohol, a surfactant, a pH adjuster, a volatile alcohol, fats and oils, a fragrance, an extract of animals and plants, etc. can be added. For example, as humectants other than polyhydric alcohol, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidone carboxylate, almond, avocado, hollyhock, aloe, usnea oil, ononis, rye, licorice, quince seed, clara (kushin), gardenia, grapefruit, cress, gentiana, gennosyoko, burdock, wheat, saishin, cactus, soapwort, Japanese quince, ginger, zenya oil, mulberry, tatijakousou, cordyceps, dokudami, peppermint, pearl barley, witch hazel, rose, hinoki, fukitampopo, grape, prune, loofah, bodaiju, hop, pine, quince, plane tree, melissa, yagurumaso, lily, lime, lavender, apple, rice and rice bran, blackcurrant, ibukitorano oil, noibara, ezoukogi, plant extracts such as seaweed, etc. can be mentioned, and one or two or more of these can be used.

[0092] Note that the liquid preparation preferably has a viscosity at 25°C of less than 5000 mPa·s, more preferably less than 4000 mPa·s. The gel preparation preferably has a viscosity at 25°C of 5000 Pa·s or more. This viscosity is measured, for example, with a viscometer (RVT type manufactured by Brookfield). Also, the amount of the thickener in the liquid preparation is preferably less than 0.05% by mass, more preferably less than 0.01% by mass, and particularly preferably less than 0.005% by mass. On the other hand, the amount of the thickener in the gel preparation is preferably 0.01% by mass or more, more preferably 0.05% by mass or more.

[0093] <(The base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), the acid and base-containing composition of the kit of (3))> The preferred amounts of the acid, carbon dioxide generating substance, and specific components in these compositions are as described above. When these compositions are in solid form, the preferred amount and content of the thickener are preferably 0.01% by mass or more and 20% by mass or less, particularly 0.05% by mass or more and 15% by mass or less in these compositions when the other agent is in gel form, from the viewpoints of good foaming properties, carbon dioxide retention properties, and the exertion of the effects of the specific components. When the other agent is in liquid form, it is preferably 0.01% by mass or more and 30% by mass or less, particularly 0.05% by mass or more and 25% by mass or less in these compositions, from the viewpoints of ease of mixing with the liquid agent, foamability, carbon dioxide retention properties, and the exertion of the effects of the specific components.

[0094] Also, as described above, the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid and base-containing composition of the kit of (3) may be in gel form or liquid form. The preferred amount of the thickener in these compositions in that case is the same as the preferred amount of the thickener in liquid or gel form in the aqueous composition of the kits of (1) to (3) described above. Further, when the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), and the acid and base-containing composition of the kit of (3) are in gel form or liquid form, the proportion of water in these compositions is 7% by mass or more, particularly 10% by mass or more, especially 20% by mass or more which is preferable from the viewpoints of foamability, persistence of bubbles, etc., and is preferably 95% by mass or less, particularly 90% by mass or less, which is preferable for enhancing the beauty effects as a topical skin preparation containing other components.

[0095] When a polyhydric alcohol is added to the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), or the acid- and base-containing composition of the kit of (3), and these compositions are in a gel state or a liquid state, the content of the polyhydric alcohol in these compositions is preferably 1% by mass or more, particularly 10% by mass or more, from the viewpoint of ease of use during use, etc., and 90% by mass or less, particularly 80% by mass or less, especially 70% by mass or less, which is preferable from the viewpoint of enhancing the cosmetic effect as a skin external preparation by containing other components. When the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), or the acid- and base-containing composition of the kit of (3) is in a gel state or a liquid state, examples of other components contained in these compositions include surfactants, preservatives, antiseptics, pH adjusters, fragrances, colorants, antioxidants, antibacterial and antifungal agents, etc.

[0096] When the base-containing composition of the kit of (1), the acid-containing composition of the kit of (2), or the acid- and base-containing composition of the kit of (3) is in a solid state, the following methods can be mentioned when granulating into granules.

[0097] When obtaining granules by granulating an acidic substance and / or a carbon dioxide-generating substance as a mixture with other components, the content of the other components is not particularly limited, but it is preferably less than 95% by mass in the above granules. When the other components are present in a content exceeding 95% by mass, the foaming property becomes low, which is not preferable. The method for producing the above powder or granules is not limited to this example, and can be produced according to conventional methods such as dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method, etc.

[0098] For example, in the production of granules, a matrix substrate having functions such as granule forming may be used. When using a low melting point compound as the matrix substrate, the carbon dioxide generating substance is added to the low melting point compound melted by heating in a container such as a beaker, and sufficiently stirred and mixed. Appropriate additives may be added thereto as necessary. This is further stirred while gradually cooling at room temperature and left to solidify. Once it has solidified to a certain extent, it may be rapidly cooled in a refrigerator or the like.

[0099] Also, for example, the above materials may be introduced into a fluidized bed granulator, mixed with an air stream for several minutes, and granulated by spraying water thereto.

[0100] When not using a low melting point compound as the matrix substrate, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, the carbon dioxide generating substance is dissolved or dispersed therein, and after sufficient mixing, it is heated in an oven or the like to remove the solvent and dried. After it has completely solidified, it is pulverized, sieved to make the particle sizes uniform, and then made into granules.

[0101] As the shape of the acidic substance and / or the carbon dioxide generating substance, for example, irregular shapes, planar shapes, polyhedral shapes, spherical shapes, droplet shapes, fibrous shapes, columnar shapes, fine powder shapes, etc. can be adopted without particular limitation. Also, as the particle size thereof, a wide range of particle sizes can be used without particular limitation. In particular, from the viewpoints of ease of handling and ease of mixing with the viscous composition, those having a particle size distribution of about 1,000 μm or less are more preferable. The above particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

[0102] The acidic substance and / or the carbon dioxide generating substance may be directly blended with the components contained in the same agent, but they are blended so as not to physically contact with other components in the same agent and may coexist. In this case, for example, a coating layer that wraps one or both of the acidic substance and / or the carbon dioxide generating substance and the other component may be provided, or one or both of the carbon dioxide generating substance and the other component may be encapsulated. Further, a layer that does not contain the carbon dioxide generating substance, the acidic substance, and other components may be sandwiched between the acidic substance and / or the carbon dioxide generating substance and other components so that they do not directly contact each other, and compression molding may be performed. Known methods can be cited as means for coexisting the acidic substance and / or the carbon dioxide generating substance and other components in the same agent.

[0103] In addition, when the kits of (1) to (3) are aqueous compositions, the mixing ratio (mass ratio) of the two is preferably 1:0.1 or more and 20 or less, and more preferably 1:0.2 or more and 10 or less. When the kits of (1) to (3) are composed of an aqueous composition and a composition that substantially does not contain water (for example, a composition in which the proportion of water is 5% by mass or less), the mixing ratio (mass ratio) of the two is preferably 1:0.01 or more and 30 or less for the former: the latter, and more preferably 1:0.05 or more and 20 or less.

[0104] In the topical skin preparation of the present invention (or used for mixing to obtain a topical skin preparation containing carbon dioxide gas), the usage amounts of the acidic substance, carbon dioxide gas generating substance, thickening agent, water, and specific component are, based on the total amount, preferably 0.1 to 15% by mass for the acidic substance, 0.1 to 20% by mass for the carbon dioxide gas generating substance, 0.1 to 20% by mass for the thickening agent, 40 to 99.6% by mass for water, and 0.01 to 30% by mass for the specific component. When the topical skin preparation contains a polyhydric alcohol, the usage amounts of the acidic substance, carbon dioxide gas generating substance, thickening agent, water, specific component, and polyhydric alcohol in the topical skin preparation (or used for mixing to obtain a topical skin preparation containing carbon dioxide gas) are, based on the total amount, preferably 0.1 to 10% by mass for the acidic substance, 0.1 to 10% by mass for the carbon dioxide gas generating substance, 0.1 to 15% by mass for the thickening agent, 30 to 97% by mass for water, 0.01 to 20% by mass for the specific component, and 0.05 to 50% by mass for the polyhydric alcohol. The amounts of these components can be obtained as the amounts in a kit for obtaining a topical skin preparation or a composition for a topical skin preparation or the amount of water mixed with the composition.

[0105] <Usage form of the composition for topical skin preparation> The composition for topical skin preparation of the present invention may be in any dosage form such as solid, liquid, gel, etc., but a solid form is preferred from the viewpoints of ease of mixing when mixed with other agents and cost during production. Among solid forms, a granular, fine-grained, or powdery form is more preferred. When using the composition for topical skin preparation, foaming is caused by mixing with a water-containing substance on the palm or in a container. Examples of the water-containing substance used include liquids containing water that are usually used in cosmetics, pharmaceuticals, etc. or used in ordinary households. The liquid containing water may be water itself. Specifically, tap water, distilled water, membrane-filtered water, ion-exchanged water, deep ocean water, as well as alcoholic beverages such as Japanese sake and wine, soy milk, drinking yogurt, acerola juice, sports drinks, carbonated water, and rice washing water can be mentioned. These may be used alone or in combination of two or more.

[0106] The amount of the hydrous substance to be used can be used in a wide range without particular limitation. For example, it is preferably added in an amount of 1 to 10 times by mass, more preferably 2 to 5 times by mass, based on the external preparation for skin. By adding a liquid in an amount exceeding 1 time, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, by adding the liquid within 10 times, dripping due to a decrease in the viscosity of the external preparation for skin can be prevented.

[0107] The temperature of the hydrous substance to be used can be used in a wide range without particular limitation, but it is particularly preferable to cool it in advance before use because the effect of carbon dioxide gas can be enhanced by the action of specific components in the external preparation for skin. From the viewpoints of the feeling of use during application and the convenience for the user, it is preferable to use water or tap water at about room temperature within the applicable temperature range.

[0108] When the constituent of the composition or kit for external preparation for skin is a solid substance, there is no particular limitation on the method of storing the kit as long as it is stored in a state where moisture is blocked and not in contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, canned shape, etc. In addition, the material constituting the storage container can be selected and used singly or in combination of two or more, for example, plastics, glass, aluminum, paper, various polymers, etc., but is not limited thereto.

[0109] Specific examples of the container include storage containers such as aluminum sticks and aluminum bags laminated with polyethylene terephthalate on the inner surface, stand pouches with a chuck, and storage containers made of polyethylene terephthalate with a lid heat-sealed with an aluminum film laminated with polyethylene terephthalate on the inner surface, etc., which are preferable in terms of airtightness, storage stability of the contents, manufacturing cost, etc.

[0110] <Use of the external preparation for skin> The external preparation for skin of the present invention promotes an increase in skin blood flow due to the action of carbon dioxide gas. The external preparation for skin of the present invention is excellent in skin improvement effects such as whitening the skin color, increasing the skin moisture content, reducing the amount of water evaporation, and improving skin elasticity. In addition, the external preparation for skin of the present invention is excellent in the feeling during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, elasticity of foam, carbon dioxide feeling and its duration, etc.) and the feeling after use (moist feeling of the skin, elasticity, brightness, redness, smoothness, slipperiness, tightening feeling, etc.). Further, the external preparation for skin of the present invention promotes skin metabolism (turnover). Furthermore, the external preparation for skin of the present invention has an activating action on skin cells by containing specific active ingredients in the carbon dioxide gas-foaming external preparation for skin, and can be used as an activator for skin cells. Also, the external preparation for skin of the present invention has effects such as activation of skin metabolism and promotion of ATP production due to the cell activating action. Taking advantage of these effects, the external preparation for skin of the present invention can be used not only for cosmetics aimed at whitening, improving skin quality, improving freckles, rejuvenating the skin, tightening the skin, partial slimming, cleansing the skin, conditioning the skin, refining the texture of the skin, keeping the skin healthy, preventing skin roughness, tightening the skin, moisturizing the skin, supplementing and maintaining skin moisture and oil, maintaining skin flexibility, protecting the skin, preventing skin dryness, softening the skin, giving firmness to the skin, giving gloss to the skin, making the skin smooth, preventing sunburn-induced spots and freckles, and making fine wrinkles caused by dryness less noticeable, but also for quasi-drugs, drugs, etc. aimed at preventing skin roughness, roughness, sweating, heat rash, cracks, red streaks, acne, oily skin, razor burn, sunburn-induced spots and freckles, preventing flushing after sunburn and snowburn, tightening the skin, cleansing the skin, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing skin dryness, etc. The external preparation for skin of the present invention is preferably used as a cosmetic or a quasi-drug, and preferably used as a cosmetic such as a lotion, a cream, a pack agent, a peeling agent, or a medicinal cosmetic. Among them, it is particularly preferable to use it as a pack agent because it has a good feeling during use and it is easy to obtain a high skin state improvement effect.

[0111] The present invention also provides a carbon dioxide gas-foaming topical skin preparation obtained by mixing an acidic substance, a carbon dioxide gas-generating substance that reacts with the acidic substance to generate carbon dioxide gas, a thickening agent, and water, and further containing the above specific components (carbon dioxide gas-containing composition).

Examples

[0112] Hereinafter, the present invention will be described more specifically with reference to examples, but the scope of the present invention is not limited to these examples. In the following examples and comparative examples, commercially available products were used unless otherwise specified. The arbutin used below is β-arbutin.

[0113] <Manufacture of foaming topical skin preparation> The components described in Tables 1 to 6 were mixed so as to have the compositions shown in the same tables, and kits for topical skin preparations of each example and comparative example were manufactured. In each of the examples and comparative examples described in Tables 1 to 6, the agent without water was in powder form, the agent with water and a thickening agent was in gel form, and the agent with water and without a thickening agent was in liquid form. In addition, the components having the compositions shown in Table 7 below were mixed to produce a powdery composition for topical skin preparation. The topical skin preparations obtained by mixing Agent A and Agent B of each example described in Tables 1 to 6 in the masses described in Tables 1 to 6 respectively were easy to apply to the skin during use and easy to use. In addition, they brought a beauty effect to the skin after use. The same was true for the topical skin preparation obtained by mixing 9 g of the composition and 27 g of water as described in Table 7 for the composition for topical skin preparation described in Table 7. In Tables 1 to 7, the acidic substance is also simply referred to as "acid", and the carbon dioxide gas-generating substance is also simply referred to as "carbonate". In addition, the glucose described in "Others" also includes its use as a polyhydric alcohol.

[0114]

Table 1

[0115]

Table 2

[0116]

Table 3

[0117]

Table 4

[0118]

Table 5

[0119]

Table 6

[0120]

Table 7

[0121] For each of the above Examples and Comparative Examples, the following [Evaluation 1] was carried out. 〔Evaluation 1〕 As subjects, two healthy women in their 20s to 30s were randomly selected. The inner forearm of each subject was washed with facial cleanser and allowed to rest quietly in the measurement room for 15 minutes. Next, the following methods were used to measure the color difference, water evaporation amount, stratum corneum water content, and elasticity of a 4 cm × 4 cm measurement part at the planned application site of the foaming topical skin preparation on the inner forearm. Next, the above foaming topical skin preparation was applied to the measurement site and allowed to stand for 10 minutes. Then, the foaming topical skin preparation was removed and washed with water. Similar measurements were carried out 15 minutes after washing, i.e., after using the foaming topical skin preparation. In addition, the subjects remained quiet in the measurement room during the measurement. The measurement results of the skin condition after use are shown in FIGS. 1A to 13B. The values in FIGS. 1A to 13B are relative values (change rates) when the measured value before using the foaming topical skin preparation is set to 1. A larger numerical value of the color difference indicates that the color has become whiter. A smaller numerical value of the water evaporation rate indicates a better result that the barrier function is intact. A larger numerical value of the stratum corneum water content indicates a better result. A larger numerical value of the elasticity indicates a better result.

[0122] The skin condition before and after applying the foaming topical skin preparation was measured using the following devices respectively. Also, these measurements were carried out by the standard methods described in the instruction manuals attached to the devices. · Color difference: Measured with a color difference meter (CR-400 manufactured by Konica Minolta). · Water evaporation rate: Measured using a Tewameter (registered trademark) TM300 (CK). · Stratum corneum water content: Measured with a skin surface stratum corneum water content measuring device SKICON-200EX (manufactured by IBS). This skin surface stratum corneum water content measuring device evaluates the skin conductance (electric conductivity, unit: μS) as the water content of the stratum corneum. · Elasticity: Measured with a skin viscoelasticity measuring device Cutometer MPA580 (manufactured by Courage+Khazaka).

[0123] As shown in FIGS. 1A to 13B, the foaming topical skin preparations of each example containing the specific component had a greater increase in color difference, stratum corneum water content, and elasticity from before use, and a smaller decrease in water evaporation rate, compared to the foaming topical skin preparations of each comparative example that did not contain this component. Therefore, it is clear that the foaming topical skin preparation of the present invention having the specific component has a high effect of improving the skin condition.

[0124] For each of the above examples and comparative examples, the following [Evaluation 2] was conducted. 〔Evaluation 2〕 As subjects, three healthy women in their 20s to 30s were randomly selected. The inner forearm of each subject was washed with facial cleanser and allowed to rest quietly in the measurement room for 15 minutes. Next, the foaming topical skin preparation was applied to the measurement site on the inner forearm and left for 10 minutes. Next, the foaming topical skin preparation was removed and washed with water. Evaluation was performed based on a 7-point evaluation criteria for the evaluation items (16 items) during and after use. The evaluation criteria are shown in Table A below, and the results are shown in Tables B to G below. Note that the following results are the average values of the evaluation scores of the three subjects.

[0125]

Table A

[0126]

Table B

[0127]

Table C

[0128]

Table D

[0129]

Table E

[0130]

Table F

[0131]

Table G

[0132] As shown in Tables B to G, the foaming topical skin preparation of each example containing the specific component was superior to the foaming topical skin preparation of each comparative example not containing the same in terms of the feel during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, elasticity of foam, carbonation sensation and its persistence), and also superior in terms of the feel after use (moist feeling of skin, elasticity, brightness, redness, smoothness, slipperiness, tightening feeling). Therefore, the foaming topical skin preparation of the present invention having the specific component has a high effect of improving the skin condition, and it is obvious that it can whiten, improve skin texture, tighten the skin, smooth the skin, refine the skin texture, tighten the skin, moisturize the skin, maintain skin flexibility, soften the skin, give firmness to the skin, smooth the skin, and make fine wrinkles due to dryness less noticeable.

[0133] For each of the above examples and comparative examples, the following [Evaluation 3] was conducted. [Evaluation 3] (Turnover test) The inner forearm of a subject (one healthy woman in her 20s to 30s selected at random) was washed with a facial cleanser and allowed to rest quietly in a measurement room for 15 minutes. Next, a cellophane tape (4 cm × 1.8 cm) was affixed to the measurement site on the inner forearm, adhered with a certain pressure, and then the operation of peeling off the tape was repeated twice. The foaming topical skin preparation after mixing was applied to the measurement site in a range of 4 cm × 4 cm and allowed to stand for 10 minutes. Next, the foaming topical skin preparation was removed and washed with water. Five minutes later, at a measurement site other than the part where the tape was affixed before application, the operation of tape affixing → peeling was similarly repeated twice. The first tape was discarded, and a vinyl chloride resin-based adhesive was thinly spread on the stratum corneum sampling surface of the second tape and affixed to a slide glass. After affixing, the slide glass was sufficiently dried, then immersed in ethanol for 10 minutes and dried at room temperature (22°C to 27°C) for 10 minutes or more. Then, it was immersed in xylene until the tape peeled off. After tape peeling, for 30 minutes to 1 hour, further slide The glass slide was immersed in xylene. After taking out the slide glass and drying it, it was immersed in a staining solution (a solution prepared by dissolving gentian violet at a concentration of 0.1 w / w% and brilliant green at a concentration of 0.5 w / w% in purified water) for 15 minutes. After washing 4 - 5 times with purified water, it was dried and observed at 200 times magnification with an optical microscope. Regarding the obtained observation images, according to the evaluation criteria shown in Table H below a five - level evaluation was performed for each of the three items described in Table H below. For the observation images before and after the use of the foaming topical skin preparation, the total value of the evaluation points (score: 5 - 1 point) for the three items was calculated, and the value obtained by subtracting the total score before use from the total score after use was determined. Note that all three items in Table H below indicate the degree of skin metabolism (turnover), and the larger the value of the evaluation point, the greater the degree of turnover. The differences in the total score before and after use obtained above are shown in FIGS. 14 - 26. Also, the observation images of the stratum corneum cells before and after the use of the foaming topical skin preparations of Comparative Example 1, Examples 1 - 19, Example 2 - 3, and Example 4 - 3 obtained by the above - mentioned microscopic observation are shown in FIG. 27.

[0134]

Table H

[0135] As shown in FIGS. 14 - 26, in each Example containing a specific component, the total score after the use of the foaming topical skin preparation increased by 2 or more from before use. On the other hand, in Comparative Examples 1 - 7, the total score after the use of the foaming topical skin preparation decreased from before use, or even if it increased, the difference from before use remained at 1 or less. Also, it is clear from FIG. 27 that the improvement from before use in terms of the stratum corneum morphology and arrangement regularity, which are indicators of turnover, after the use of the foaming topical skin preparation is remarkable in the Examples, but not obtained in the Comparative Examples. Therefore, it is clear that the foaming topical skin preparations of each Example are excellent in the effect of promoting turnover compared to each Comparative Example.

[0136] The specific component used in the present invention was subjected to a cell activation test according to the following procedures (1) - (5). 〔Cell Activation Test 1〕 (1) Using a 75 cm flask, normal 2 human dermal fibroblasts (NHDF) were cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum (10% FBS-DMEM) at 37°C in a 5% CO2 incubator. (2) After suspending the cells cultured in (1) by trypsin treatment, they were seeded at a cell density of 1×10 2 cells / well from the 75 cm flask into each well of a 96-well plate. 4 (3) The cells seeded in (2) were pre-cultured in 10% FBS-DMEM medium at 37°C in a 5% CO2 incubator for 24 hours. (4) After the pre-culture in (3), the medium was removed from each well, and after washing once with 200 μL / well of serum-free DMEM, 200 μL of the test substance-containing medium prepared at a predetermined concentration was added to each well. The cells after the addition of the test substance-containing medium were cultured in a 5% CO2 incubator at 37°C for 24 hours. The test substance-containing medium was prepared as in Preparation Method 1 below. (Preparation Method 1 of Test Substance-Containing Medium) Sodium hydrogen carbonate, malic acid, the thickener described in Table 8 below, and arbutin as a specific component were mixed in serum-free DMEM so that the final concentration of sodium hydrogen carbonate was 62.5 mM, the final concentration of malic acid was 20.8 mM, and the final concentrations of the thickener and the specific component were the values in Table 8 below.

[0137]

Table 8

[0138] (5) The cultured cells were washed once with 200 μL / well of PBS. 150 μL / well of the Cell Counting Kit-8 solution diluted 30-fold with serum-free DMEM was added. Then, after standing in a 5% CO2 incubator at 37°C for appropriate color development, the absorbance at 450 nm was measured.​​ Based on the obtained absorbance, the cell activation activity (%) was calculated using the following formula. For Data control in the following formula, the data from Reference Example 1 was used. Cell activation activity (%) = (Data sample - Data blank) / (Data control - Data blank) × 100

[0139] The results of the cell activation activity are shown in Figure 28. As shown in Figure 28, it can be seen that by combining the specific component with a thickening agent, an acidic component, and a carbon dioxide generating component, the cell activation activity can be enhanced.

[0140] Also, the specific components described in Table 9 below were subjected to the following [Cell Activation Test 2]. [Cell Activation Test 2] The method for preparing the test substance-containing medium was changed to the following Preparation Method 2. Also, when calculating the cell activation activity (%), serum-free DMEM without the test substance was used as Data control. Otherwise, it was the same as the above [Cell Activation Test 1]. The results are shown in Table 9 below. (Preparation Method 2 of the Test Substance-Containing Medium) The specific components described in Table 9 below were mixed into serum-free DMEM so that the final concentrations were the values in Table 9 below. Also, in Table 9 below, when the item "carbonic acid" is described as "present", sodium bicarbonate and malic acid were mixed into serum-free DMEM together with the specific components so that the final concentration of sodium bicarbonate was 31.2 mM and the final concentration of malic acid was 6.25 mM. When the item "carbonic acid" in Table 9 below is described as "-", only the specific components were mixed into serum-free DMEM, and sodium bicarbonate and malic acid were not used.

[0141] [Table 9]

[0142] As described above, it was confirmed that the cell activation activity was increased by the foaming topical skin preparation containing the specific component.

Claims

[Claim 1] A one-component foamable skin preparation for external use, which contains an acidic substance, a carbonate, and a thickener, and further contains at least one selected from ascorbic acid-2-glucoside and tranexamic acid, and is characterized in that the foamable skin preparation for external use is mixed with a water-containing substance when used.

Images