Liquid detergent composition

Abstract

To provide a detergent composition having less skin irritation and good washability and rinsability and having an excellent bactericidal effect and an excellent virus inactivation effect even in the presence of organic stains.SOLUTION: There is provided an alkyltrimethylammonium salt as a component (A-β); a pH adjuster as a component (B), at least one selected from a nonionic surfactant and an amphoteric surfactant as a component (C), a polyhydric alcohol as a component (D) and water as a component (E), wherein the total amount of the component (A-α) and the component (A-β) is less than 0.6 mass%, the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) to the mass of the component (A-β) is 0.01 or more and less than 1 and the pH at 25°C is 8.0 or more and 12.0 or less.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an alkaline liquid detergent composition for skin. More specifically, it relates to a detergent composition mainly used for washing fingers, having less skin irritation, good detergency and rinsability, and excellent bactericidal effect and virus inactivating effect even in the presence of organic dirt.

[0002] Regarding the cleaning and sterilization of fingers of employees in the food-related industry such as meat and seafood processing and restaurant kitchens, and doctors, nurses, caregivers, patients, etc. in hospitals, health centers, etc., various methods have been conventionally taken. The most common method is to first wash the fingers well with a finger detergent and then undergo a sterilization treatment such as immersion or spraying of the fingers with a finger disinfectant. These methods can be said to be effective when carried out faithfully according to the cleaning and sterilization manuals. However, when the finger washing is insufficient, there is a problem that the bactericidal power due to the subsequent sterilization treatment is extremely reduced, and there is a case of bringing microorganisms that cause food poisoning to the site.

[0003] In recent years, the number of cases and patients of food poisoning caused by norovirus has been increasing in the food poisoning occurrence situation, and it has become a major problem due to its high infectivity. The causes of food poisoning by norovirus are not only factors such as eating bivalves such as oysters, but also secondary infections caused by contact with human feces, vomit, and eating contaminated foods through cooks infected with norovirus are also major factors.

[0004] In order to prevent the introduction of food poisoning bacteria and secondary contamination by norovirus, thorough handwashing is required, and it is important that food manufacturers and cooking staff do not bring microorganisms and viruses to the site.

[0005] Furthermore, it is generally known that the bactericidal effect of bactericides and the like decreases in the presence of organic dirt. Food manufacturers and cooks may have organic dirt from food adhering to their hands, and there is a risk that the bactericidal effect and virus inactivating effect of hand cleaners will be difficult to exhibit. For this reason, hand cleaners are required to provide a bactericidal effect and a virus inactivating effect even in the presence of organic dirt.

[0006] Detergents used for conventional hand washing applications include liquid detergent compositions containing fatty acids, alkylaminocarboxylic acid type amphoteric surfactants, and chelating agents, with a pH of 9.5 to 11 (Patent Document 1); an anionic surfactant having a specific structure as component (A), a glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms as component (B), at least one bactericide selected from the group consisting of triclosan, isopropylmethylphenol, and parachlorometaxylenol as component (C), an alkyl glycoside as component (D), and a saturated monohydric alcohol with 1 to 3 carbon atoms as component (E), where the mass ratio (B) / (E) of component (B) to component (E) is 0.10 to 5 (Patent Document 2); a liquid skin detergent composition characterized by containing a quaternary ammonium salt type surfactant as component (A), a pH adjuster as component (B), at least one selected from nonionic surfactants and amphoteric surfactants as component (C), water as component (D), and a polyhydric alcohol as component (E), where the mass ratio of component (A) to component (B) is 0.002 or more and 100 or less in terms of the value of (A) / (B), the mass ratio of component (A) to component (E) is 0.001 or more and 1 or less in terms of the value of (A) / (E), and the pH at 25°C is 8.1 or more and 12.0 or less (Patent Document 4). Also, as a technology related to the virus inactivating effect, there is an antiviral detergent composition containing a quaternary ammonium salt, a nonionic surfactant and / or an amphoteric surfactant, and an alkaline agent, with a pH of 11 or more at 25°C (Patent Document 3).

Prior Art Documents

Patent Documents

[0007] Patent Document 1 International Publication No. 2013 / 141118 Patent Document 2 Japanese Unexamined Patent Application Publication No. 2020-026407 Patent Document 3 Japanese Unexamined Patent Application Publication No. 2019-052118 Patent Document 4 Japanese Patent No. 6860734 Summary of the Invention Problems to be Solved by the Invention

[0008] The liquid detergent composition of Patent Document 1 shows a certain detergency because its pH is in the alkaline range, but its bactericidal effect is insufficient and the virus inactivation effect cannot be obtained. Although the skin detergent composition of Patent Document 2 shows a bactericidal effect and detergency, since its pH is in the neutral range, the virus inactivation effect cannot be obtained. The antiviral detergent composition of Patent Document 3 can inactivate viruses and wash the objects to be washed by wiping with an antiviral cleaning material impregnated into a non-woven fabric or spraying with a spray and then rinsing with water for objects to be washed having hard surfaces such as kitchen countertops, refrigerators, toilets, and floors. However, because of its strong irritation to the skin, operators need to wear gloves to work. The liquid detergent composition of Patent Document 4 can be used for washing fingers, has little skin irritation, and is excellent in detergency, bactericidal effect, and virus inactivation effect. However, there is still room for improvement in the bactericidal effect and virus inactivation effect in the presence of organic dirt.

[0009] The present invention has been found to solve the above problems. That is, an object of the present invention is to provide a detergent composition that has little skin irritation, good detergency and rinsability, and excellent bactericidal and virus inactivation effects even in the presence of organic dirt. Means for Solving the Problems

[0010] In order to solve the above problems, as a result of intensive studies by the present inventors, an alkyltrimethylammonium salt as the (A-α) component, an alkyldimethylbenzylammonium salt as the (A-β) component, a pH adjuster as the (B) component, a nonionic surfactant, at least one selected from amphoteric surfactants as the (C) component, a polyhydric alcohol as the (D) component, and water as the (E) component are contained. Furthermore, a composition containing the total amount of the (A-α) component and the (A-β) component within a specific range and having a specific ratio of the (A-α) component to the (A-β) component has low irritation to the skin, excellent detergency, and a good bactericidal effect and virus inactivating effect even in the presence of organic dirt. Based on these findings, the present invention has been completed.

[0011] That is, the liquid alkaline detergent composition for skin of the present invention contains an alkyltrimethylammonium salt as the (A-α) component, an alkyldimethylbenzylammonium salt as the (A-β) component, a pH adjuster as the (B) component, a nonionic surfactant, at least one selected from amphoteric surfactants as the (C) component, a polyhydric alcohol as the (D) component, and water as the (E) component. The total amount of the (A-α) component and the (A-β) component is less than 0.6% by mass, and the value of the mass ratio (A-α) / (A-β) of the mass of the (A-α) component to the mass of the (A-β) component is 0.01 or more and less than 1, and the pH at 25°C is 8.0 or more and 12.0 or less.

[0012] Also, in the present invention, it is preferable that the value of the mass ratio (C) component / (A) component of the mass of the (C) component to the mass of the (A) component is 0.1 or more and 150 or less. Further, in the present invention, as the (B) component, it is preferable to contain at least one selected from alkali metal hydroxides, alkali metal silicates, alkanolamines, alkali metal carbonates, alkali metal phosphates, and organic acid salts.

[0013] The present invention preferably contains, as component (C), at least one selected from polyoxyalkylene alkyl ethers, alkyl glucosides including alkyl polyglucosides, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkylamino (mono- or di-) propionates, and alkyldimethylamine oxides.

[0014] The present invention preferably contains, as component (D), at least one selected from ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol. In the present invention, the above-described alkaline liquid detergent composition for skin is preferably a liquid detergent for fingers.

Effects of the Invention

[0015] The alkaline liquid detergent composition for skin of the present invention is excellent in bactericidal effect and virus inactivating effect against bacteria in the presence of organic dirt.

Modes for Carrying Out the Invention

[0016] The alkaline liquid detergent composition for skin of the present invention contains, as component (A-α), an alkyltrimethylammonium salt, as component (A-β), an alkyldimethylbenzylammonium salt, as component (B), a pH adjuster, as component (C), at least one selected from nonionic surfactants and amphoteric surfactants, as component (D), a polyhydric alcohol, and as component (E), water, and the total amount of the component (A-α) and the component (A-β) is less than 0.6% by mass, and the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) to the mass of the component (A-β) is 0.01 or more and less than 1.

[0017] (A-α) Alkyltrimethylammonium salt The alkyltrimethylammonium salt used in the present invention has the general formula ([R 1 N(CH3)3〕 + ·X- ) is represented by. Here, R 1 is a linear or branched alkyl group having 8 to 22 carbon atoms, and X represents a halogen atom. As R 1 , for example, alkyl groups such as octyl group, nonyl group, decyl group, undecyl group, lauryl group, tridecyl group, myristyl group, pentadecyl group, heptadecyl group, stearyl group, nonadecyl group, eicosyl group and the like can be mentioned. Among these, an alkyl group having 10 to 18 carbon atoms is preferable, an alkyl group having 12 to 18 carbon atoms is more preferable, an alkyl group having 14 to 18 carbon atoms is further preferable, and an alkyl group having 16 carbon atoms is most preferable.

[0018] X represents a group forming a counter ion, and examples thereof include a halogen atom and alkyl sulfuric acid. Among these, a halogen atom, particularly a chlorine atom and a bromine atom, is preferable.

[0019] Specific examples of the alkyltrimethylammonium salt include lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, coconut alkyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, behenyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide, etc. Among these, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, coconut alkyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide are preferred, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide are more preferred, and cetyltrimethylammonium chloride and cetyltrimethylammonium bromide are even more preferred.

[0020] (A-β) alkyldimethylbenzylammonium salt The alkyldimethylbenzylammonium salt used in the present invention is represented by the general formula ([C6H5CH2N(CH3)2R 2 〕 + ·X - ). Here, R 2 represents a linear or branched alkyl group having 8 to 18 carbon atoms. Examples of R 2 include octyl group, nonyl group, decyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, etc. Among these, R2 is preferably a carbon number of 12 to 16.

[0021] X represents a group forming a counter ion, and examples thereof include a halogen atom and alkyl sulfuric acid. Among these, a halogen atom, particularly a chlorine atom, is preferable.

[0022] Examples of the alkyldimethylbenzylammonium salt include alkyl (C12 - 16) dimethylbenzylammonium chloride, octyldimethylbenzylammonium chloride, decyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, and the like. Among these, alkyl (C12 - 16) dimethylbenzylammonium chloride is preferable.

[0023] (Component A) contributes to the bactericidal power and virus inactivation in the alkaline liquid detergent composition for skin of the present invention. Therefore, if the blending amounts of (Component A-α) and (Component A-β) are too small, the bactericidal power or virus inactivation effect of the alkaline liquid detergent composition for skin may be insufficient. On the other hand, if the blending amounts of (Component A-α) and (Component A-β) are too large, the skin irritation becomes strong, and it may have an undesirable influence on rinsability and storage stability. From such a viewpoint, the concentration of the total amount of (Component A-α) and (Component A-β) in the alkaline liquid detergent composition for skin of the present invention is less than 0.6% by mass, preferably 0.01% by mass or more and less than 0.6% by mass, more preferably 0.03% by mass or more and 0.57% by mass or less, still more preferably 0.06% by mass or more and 0.54% by mass or less, and particularly preferably 0.10% by mass or more and 0.50% by mass or less.

[0024] The alkaline liquid detergent composition for skin of the present invention may contain a quaternary ammonium salt type surfactant other than the component (A-α) and the component (A-β) (hereinafter referred to as "other quaternary ammonium salts") as long as the effects of the present invention are not impaired. However, with respect to the total amount of the component (A-α), the component (A-β), and other quaternary ammonium salts, the total amount of the component (A-α) and the component (A-β) is preferably at least 80% by mass, more preferably at least 90% by mass, and particularly preferably at least 95% by mass. Further, as another embodiment, the alkaline liquid detergent composition for skin of the present invention does not contain other quaternary ammonium salts. Also, it is preferable that the total amount of the component (A-α), the component (A-β), and other quaternary ammonium salts is less than 0.6% by mass with respect to the total amount of the alkaline liquid detergent composition for skin.

[0025] From the viewpoints of bactericidal power and virus inactivation effect, the component (A-α) used in the present invention is preferably 0.005% by mass or more and 0.3% by mass or less, more preferably 0.008% by mass or more and 0.27% by mass or less, further preferably 0.01% by mass or more and 0.24% by mass or less, and particularly preferably 0.01% by mass or more and 0.15% by mass or less with respect to the total amount of the alkaline liquid detergent composition for skin of the present invention.

[0026] The component (A-β) used in the present invention is preferably 0.005% by mass or more and 0.59% by mass or less, more preferably 0.01% by mass or more and 0.5% by mass or less, further preferably 0.05% by mass or more and 0.3% by mass, and particularly preferably 0.1% by mass or more and 0.2% by mass or less with respect to the total amount of the alkaline liquid detergent composition for skin of the present invention. If the component (A-β) is less than 0.005% by mass, sufficient bactericidal power and virus inactivation effect cannot be obtained. Also, if it is more than 0.59% by mass, skin irritation may become strong, and the rinsability and storage stability may decrease.

[0027] In the skin alkaline liquid detergent composition of the present invention, it is necessary that the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) and the mass of the component (A-β) is 0.01 or more and less than 1. It is preferably 0.02 or more and 0.9 or less, more preferably 0.06 or more and 0.8 or less, and particularly preferably 0.1 or more and 0.75 or less. If this value is less than 0.01, a decrease in bactericidal power is observed, and if it is 1.0 or more, a decrease in the virus inactivation effect is observed.

[0028] Here, the virus includes an enveloped virus which is a virus having an envelope, and a non-enveloped virus which is a virus not having an envelope.

[0029] Examples of the virus having an envelope include, but are not limited to, human herpesvirus, vaccinia virus, influenza virus, SARS coronavirus, MERS coronavirus, SARS-CoV-2, RS virus, mumps virus, Lassa virus, dengue virus, rubella virus, human immunodeficiency virus, measles virus, hepatitis B virus, hepatitis C virus, Ebola virus, yellow fever virus, and Japanese encephalitis virus.

[0030] Examples of the virus not having an envelope include, but are not limited to, norovirus, poliovirus, echovirus, rhinovirus, astrovirus, rotavirus, coxsackievirus, enterovirus, sapovirus, adenovirus, human parvovirus B19 virus, human papillomavirus, hepatitis A virus, and hepatitis E virus.

[0031] (B) pH adjuster Component (B) is a pH adjuster for adjusting the pH of the skin alkaline liquid detergent composition of the present invention. Considering the blending amounts of other components, the pH of the liquid detergent composition of the present invention is preferably adjusted to a range of 8.0 or more and 12.0 or less by component (B). General alkaline detergents are strongly irritating to the skin and direct use on fingers is avoided. However, the present invention, although alkaline, can exhibit high detergency, bactericidal power, and virus inactivating effect (hereinafter also referred to as detergency, etc.) while suppressing irritation to the skin due to the blending of component (A) and component (C).

[0032] From the viewpoint of more fully exhibiting detergency, bactericidal power, and virus inactivating effect, the above pH is preferably 9 or more, more preferably 9.5 or more. Also, from the viewpoint of providing a detergent with less skin irritation, the above pH is preferably 11.5 or less, more preferably 11 or less, and particularly preferably less than 11.

[0033] As the above pH adjuster, it can be selected from compounds capable of adjusting the pH of the liquid detergent composition without impairing the effects of the present invention. For example, as the pH adjuster, any one or combination selected from alkali metal hydroxides, alkali metal silicates, alkanolamines, alkali metal carbonates, alkali metal phosphates, and organic acid salts can be mentioned.

[0034] Examples of the alkali metal hydroxide include sodium hydroxide, potassium hydroxide, etc. Examples of the alkali metal silicate include sodium orthosilicate, potassium orthosilicate, sodium metasilicate, potassium metasilicate, sodium silicate No. 1, sodium silicate No. 2, sodium silicate No. 3, potassium A silicate, potassium B silicate, or potassium C silicate, etc. Examples of the alkanolamine include monoethanolamine, diethanolamine, or triethanolamine, etc. Examples of the alkali metal carbonate include sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium sesquicarbonate, potassium sesquicarbonate, sodium percarbonate, potassium percarbonate, and the like. Examples of the alkali metal phosphate include sodium phosphate, potassium phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, and the like. Examples of the organic acid salt include sodium citrate, potassium citrate, trisodium citrate, tripotassium citrate, sodium gluconate, potassium gluconate, sodium lactate, potassium lactate, sodium acetate, potassium acetate, and the like.

[0035] From the viewpoint of detergency, the component (B) is preferably an alkali metal hydroxide or an alkanolamine. Further, from the viewpoint of good virus inactivation against the object to be washed with organic soil attached, it is preferable to use in combination an alkali metal hydroxide and / or an alkanolamine with at least one selected from alkali metal carbonates, alkali metal phosphates, and organic acid salts. It is presumed that due to the buffering action of the carbonate, phosphate or organic acid salt, the decrease in pH is suppressed even when soil is attached, and an excellent virus inactivation effect is exhibited.

[0036] The proportion of the component (B) relative to the total amount of the liquid skin cleansing agent composition of the present invention is preferably 0.05% by mass or more and 5.0% by mass or less, more preferably 0.1% by mass or more and 4.0% by mass or less, and particularly preferably 0.3% by mass or more and 3.0% by mass or less. If it is less than 0.05% by mass, the bactericidal power and virus inactivation effect may not be sufficient. If it is more than 5% by mass, the skin irritation may increase and the storage stability may decrease.

[0037] When a general liquid detergent composition is brought into contact with an object to be washed having dirt such as organic matter attached thereto, the pH of the liquid detergent composition may significantly decrease. As a result, the detergency and the like may decrease, and the object to be washed may not be sufficiently washed and sterilized. And there is a problem that sufficient sterilization cannot be achieved even when a disinfectant or the like is sprayed on an object to be washed with dirt remaining thereon for sterilization treatment. On the other hand, in the liquid detergent composition of the present invention, since the pH is adjusted to a predetermined range by the pH adjuster as the component (B), even when it comes into contact with organic dirt, it is easy to maintain alkalinity, and as a result, high detergency and the like are easily maintained. Weak bases such as sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium citrate, and tripotassium citrate can suppress a decrease in the pH of the liquid detergent composition even when in contact with dirt due to their buffering action, maintain high detergency and the like, and can exhibit a good virus inactivating effect on an object to be washed with organic dirt attached thereto.

[0038] (C) Nonionic surfactant · Amphoteric surfactant The skin alkaline liquid detergent composition of the present invention contains at least one selected from nonionic surfactants and amphoteric surfactants as the component (C). These surfactants contribute to realizing good detergency while suppressing irritation to the skin, and also contribute to good foaming during use.

[0039] Examples of the nonionic surfactant as the component (C) include aliphatic alkanolamides, polyoxyalkylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyoxypropylene glycols, sucrose fatty acid esters, monoglycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, alkylene oxide adducts of sorbitan fatty acid esters, or alkyl glucosides. The carbon number of the above alkyl group is not particularly limited, but is preferably 6 or more and 14 or less. More specifically, octyl glucoside, decyl glucoside, lauryl glucoside, etc. can be mentioned.

[0040] Examples of the amphoteric surfactant as the above component (C) include betaine-type amphoteric surfactants, amino acid-type amphoteric surfactants, amine oxide-type amphoteric surfactants, and the like.

[0041] Regarding the present invention, the betaine-type amphoteric surfactant refers to a surfactant having betaine in its molecular structure and exhibiting amphiphilicity thereby. Here, betaine refers to an inner salt having a positive charge and a negative charge at non-adjacent positions within the same molecule. The above betaine-type amphoteric surfactants include alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, and fatty acid amide propyl betaine-type amphoteric surfactants.

[0042] Examples of the above alkyl betaine-type amphoteric surfactants include alkyl dimethylaminoacetic acid betaine, alkyl dimethylaminosulfobetaine, alkyl hydroxysulfobetaine, etc. The carbon number of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. More specifically, lauryl dimethylaminoacetic acid betaine, stearyl dimethylaminoacetic acid betaine, etc. can be mentioned. Examples of the above alkyl imidazolinium betaine-type amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine, etc. The carbon number of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. Examples of the above alkylamidopropyl betaine type amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, myristic acid amidopropyl betaine, ricinoleic acid amidopropyl betaine, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less.

[0043] Regarding the present invention, examples of the amino acid type amphoteric surfactants include alkyldiaminoethyl glycine, alkylaminopropyl glycine, glycine n-(3-aminopropyl) C10-16 derivatives, alkylpolyaminoethyl glycine, carboxymethyl glycine, alkylamino (mono or di) propionate, alkylaminodiacetate, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 16 or less. More specifically, dodecyldiaminoethyl glycine, tetradecyldiaminoethyl glycine, dodecyldiaminoethyl glycine chloride, tetradecyldiaminoethyl glycine chloride, sodium lauryl propionate, sodium laurylaminodipropionate, and the like can be mentioned.

[0044] Regarding the present invention, examples of the amine oxide type amphoteric surfactants include alkyldimethylamine oxide, alkylamidopropyldimethylamine oxide, dihydroxyethylalkylamine oxide, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. More specifically, octyldimethylamine oxide, decyldimethylamine oxide, lauryldimethylamine oxide, myristyldimethylamine oxide, coconut oil alkyldimethylamine oxide, lauric acid amidopropyldimethylamine oxide, dihydroxyethyl coconut oil alkylamine oxide, and the like can be mentioned.

[0045] From the perspective of providing a liquid detergent composition that exhibits more favorable foaming and rinsing properties, as the component (C) described above, it is preferable to contain at least one selected from polyoxyalkylene alkyl ethers such as polyoxyethylene alkyl ether, alkyl glucoside, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkyl amino (mono- or di-) propionate salts, and alkyl dimethylamine oxide. Among them, as the component (C), it is more preferable to contain at least one of alkyl glucoside containing alkyl polyglucoside, alkyl betaine-type amphoteric surfactants, and alkyl imidazolinium betaine-type amphoteric surfactants.

[0046] The content of the nonionic surfactant or amphoteric surfactant as the component (C) can be appropriately determined within a range that does not impair the effects of the present invention. With respect to the total amount of the skin alkaline liquid detergent composition, the ratio of the component (C) is preferably 0.1% by mass or more and 8.0% by mass or less, more preferably 0.5% by mass or more and 6% by mass or less, and particularly preferably 1.0% by mass or more and 6% by mass or less. If the component (C) is less than 0.1% by mass, good foaming may not be obtained, and if it is higher than 8.0% by mass, the storage stability may decrease.

[0047] In the skin alkaline liquid detergent composition of the present invention, the value of the mass ratio (C) / (A) of the mass of the component (C) to the mass of the component (A) is preferably 0.1 or more and less than 150, more preferably 0.2 or more and 130 or less, and even more preferably 0.8 or more and 100 or less. By including this value within the above range, it is possible to achieve both good foaming and bactericidal power.

[0048] (D) Polyhydric alcohol The skin alkaline liquid detergent composition of the present invention contains a polyhydric alcohol as the component (D). By blending the component (D), it is possible to further reduce the skin irritation of the skin alkaline liquid detergent composition with a high pH.

[0049] Examples of the component (D) include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,4-butanediol, 1,5-pentanediol, hexylene glycol, glycerin, polyglycerin, sorbitol, etc. Among them, ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol are preferable, and particularly glycerin, propylene glycol, and polyethylene glycol are preferable.

[0050] From the viewpoint of exerting the effect of suppressing skin irritation, the blending amount of the component (D) is preferably 0.1% by mass or more and 10% by mass or less, more preferably 0.5% by mass or more and 8% by mass or less, and particularly preferably 1% by mass or more and 6% by mass or less with respect to the total amount of the liquid alkaline detergent composition for skin. If the concentration of the component (D) is less than 0.1% by mass, the effect of suppressing skin irritation may not be sufficient, and even if it is blended in an amount more than 10% by mass, no effect commensurate with the blending amount is observed.

[0051] (E) Water The liquid detergent composition of the present invention contains water as component (E). There are no particular limitations on the water as the above-mentioned component (E), and tap water, softened water, pure water, RO water, ion-exchanged water, distilled water can be used. Examples of tap water include tap water in Arakawa-ku, Tokyo (pH = 7.6, total alkalinity (in terms of calcium carbonate) 40.5 mg / L, German hardness 2.3 °DH (of which calcium hardness is 1.7 °DH and magnesium hardness is 0.6 °DH), chloride ion 21.9 mg / L, sodium and its compounds 15 mg / L, nitrate nitrogen and nitrite nitrogen 1.2 mg / L, fluorine and its compounds 0.1 mg / L, boron and its compounds 0.04 mg / L, total trihalomethane 0.016 mg / L, residual chlorine 0.4 mg / L, organic matter (total organic carbon content) 0.7 mg / L). The water of component (E) of the present invention is the remainder with respect to the total amount of the above-mentioned components (A) to (D), or the remainder with respect to the total amount of components (A) to (D) and other optional components.

[0052] The liquid detergent composition of the present invention may contain other components commonly used in the art as necessary, as long as the effects of the present invention are not impaired. Such components include, for example, fatty acids such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, coconut fatty acid or salts thereof, metal corrosion inhibitors such as benzotriazole, tolyltriazole, benzothiazole, 1-hydroxyethylidene-1,1-diphosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, aminotrimethylenephosphonic acid, alcohol solvents such as ethanol, isopropanol, phenoxyethanol, glycol ether solvents such as diethylene glycol monobutyl ether, dipropylene glycol monobutyl ether, chelating agents such as ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, triethylenetetraminehexaacetic acid, methylglycine diacetic acid, glutamic acid diacetic acid or salts thereof, bactericides such as isopropylmethylphenol, triclosan, triclocarban, thickeners such as xanthan gum, inorganic electrolytes such as sodium chloride, fragrances, dyes and the like. Among the above components, fatty acids are preferably formulated in terms of foamability and rinsability, alcohol solvents are preferably formulated in terms of bactericidal power, glycol ether solvents are preferably formulated in terms of storage stability, and thickeners and inorganic electrolytes are preferably formulated in terms of foamability. When the above alcohol solvent is contained in the liquid detergent composition from the viewpoint of improving the bactericidal power while suppressing skin irritation, the alcohol solvent is preferably contained in a range of, for example, 0.01% by mass or more and 1.0% by mass or less, more preferably in a range of 0.05% by mass or more and 0.8% by mass or less, and still more preferably in a range of 0.1% by mass or more and 0.6% by mass or less.

[0053] In the case of the skin alkaline liquid detergent composition of the present invention, when each component is in a liquid state, it is generally carried out by mixing and stirring, and when it contains solid components, it is first dissolved in water and then other liquid components are added and mixed and stirred. However, depending on the composition, the addition order of each component, the dissolution order, and the manufacturing procedures such as heating / cooling performed as necessary are not particularly limited.

[0054] The alkaline liquid detergent composition for skin of the present invention can be used by foaming the liquid detergent composition with the palm of the hand or with a sponge, etc., or can be filled in a former container and used as a foamy detergent extruded from the former container when in use.

[0055] The alkaline liquid detergent composition for skin of the present invention preferably has human skin as the object to be cleaned, and more preferably is used as a so-called hand soap for cleaning fingers and the like. Further, the time when cleaning is performed using the alkaline liquid detergent composition for skin of the present invention is not particularly limited, but from the viewpoint of more thoroughly cleaning fingers, it is preferably 10 seconds or more and less than 90 seconds, and more preferably 20 seconds or more and less than 60 seconds.

Examples

[0056] Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. The respective components used in the formulation of the liquid detergent compositions of the Examples and Comparative Examples are shown in Tables 1 to 7 below. In addition, the numerical values regarding the formulation amounts shown in Tables 1 to 7 below are the ratios (mass%) of the pure components of each component to the liquid detergent composition.

[0057] (Component (A)) A-α1: Hexadecyltrimethylammonium chloride A-α2: Stearyltrimethylammonium chloride A-α3: Lauryltrimethylammonium chloride A-α4: Alkyl (C14 - C18) trimethylammonium chloride A-β: Alkyl (C12 - C16) dimethylbenzylammonium chloride A-γ: Dialkyl (C10) methylhydroxyethylammonium propionate

[0058] (Component (B)) B-1: Potassium hydroxide B-2: Monoethanolamine B-3: Sodium hydrogen carbonate B-4: Sodium carbonate B-5: Trisodium citrate B-6: Disodium hydrogen phosphate B-7: Sodium dihydrogen phosphate

[0059] (C) component C-1: Lauryl glucoside C-2: Lauramidopropyl betaine C-3: Sodium lauryldipropionate C-4: 2-Alkyl (C8-C18)-N-carboxyethyl-N-hydroxyethylimidazolinium betaine C-5: Polyoxyethylene alkyl ether (having a straight-chain hydrocarbon group with 12 carbon atoms and an average added mole number of oxyethylene groups = 7) C-6: Lauryl dimethylamine oxide

[0060] (D) component D-1: Glycerin D-2: Propylene glycol D-3: Polyethylene glycol (weight-average molecular weight 400)

[0061] (E) component E-1: Ion-exchanged water

[0062] Other components F-1: Disodium ethylenediaminetetraacetate F-2: Trisodium methylglycinediacetate F-3: Tetrasodium glutamate diacetate F-4: Sodium chloride F-5: Ethanol F-6: Phenoxyethanol

[0063] ※1: Cleaning performance test <Test method> This test was carried out once a day after work for 10 panelists who perform office work and on-site work in accordance with the instruction manual using a wiping test tool (Lucipac (registered trademark) PEN; manufactured by Kikkoman Corporation). One type of liquid detergent composition was used per day for the test. First, pull out the cotton swab set in the main body of the above-mentioned Lucipac PEN, and wipe both hands of each panelist with the cotton swab before handwashing, and use this as a wiped sample. Return the above-mentioned wiped sample to the main body of the Lucipac PEN, and fully immerse it in the luminescent reagent in the measurement tube provided at the tip of the Lucipac PEN. Then, using a luminescence measurement device (Lumitester (registered trademark) PD-30; manufactured by Kikkoman Corporation), insert the Lucipac PEN into the measurement chamber of the above-mentioned Lumitester PD-30, and measure the ATP luminescence amount (RLU0) before handwashing.

[0064] After preparing the above-mentioned wiped sample, each panelist took 1 mL of the liquid detergent composition in their hand, washed their hands for 30 seconds, rinsed with tap water for 30 seconds, drained the water thoroughly, and finished handwashing. After handwashing, the ATP luminescence amount (RLU1) after handwashing of each panelist was measured in the same manner as above. Using the measured values of the ATP luminescence amount (RLU0) before handwashing and the ATP luminescence amount (RLU1) after handwashing, the cleaning rate by handwashing was calculated according to the following (Formula 1), the average value of the cleaning rates of 10 panelists was obtained, and the detergency was evaluated according to the evaluation criteria described below. (Formula 1) Cleaning rate (%) = 100 - RLU1 / RLU0 × 100 ····· (1)

[0065] <Evaluation criteria> ◎: The cleaning rate is 90% or more. ○: The cleaning rate is 75% or more and less than 90%. △: The cleaning rate is 60% or more and less than 75%. ×: The cleaning rate is less than 60. It was determined that △, ○, and ◎ were practical.

[0066] ※2: Bactericidal power test against general bacteria <Test bacteria> As test bacteria, Escherichia coli (Escherichia coli NBRC3972) and Staphylococcus aureus (Staphylococcus aureus NBRC12732) were used. Each test bacterium was smeared on an SCD agar medium (manufactured by Eiken Chemical Co., Ltd.), cultured at 37°C for 24 hours, the colonies were scraped off, and each was diluted in sterile phosphate-buffered saline and used as a bacterial suspension. <Test method> To 10 mL of each liquid detergent composition, 0.1 mL of each bacterial suspension was added so that the final concentration was 1.5 - 5.0×10 8 (CFU / mL), and after contacting at 25°C for 15 seconds, a sterile neutralizing solution (SCDLP medium, manufactured by Eiken Chemical Co., Ltd.) was added and stirred well to obtain a test solution. Also, assuming organic soil, to 10 mL of each liquid detergent composition containing 0.1% by mass of yeast extract as soil, 0.1 mL of each bacterial suspension was added so that the final concentration was 1.5 - 5.0×10 8 (CFU / mL), and after contacting at 25°C for 30 seconds, a sterile neutralizing solution (SCDLP medium, manufactured by Eiken Chemical Co., Ltd.) was added and stirred well to obtain a test solution. 1 mL of these was mixed and solidified on an SCD agar medium and cultured at 37°C for 2 days. After culturing, the viable cell count was measured, and the logarithmic reduction value (Log reduction value) was determined from the difference from the initial bacterial count, and the bactericidal power was evaluated according to the following criteria.

[0067] <Evaluation criteria> 1 point: A reduction in the number of bacteria with a Log reduction of the test bacteria of 5 or more 2 points: A reduction in the number of bacteria with a Log reduction of the test bacteria of 3 or more and less than 5 3 points: A reduction in the number of bacteria with a Log reduction of the test bacteria of 1 or more and less than 3 4 points: A reduction in the number of bacteria with a Log reduction of the test bacteria of less than 1 The reduction in the number of bacteria for each bacterial species was evaluated in points.

[0068] The average value of the scores of the above evaluations for the two types of bacteria was determined, and the bactericidal power was evaluated according to the following criteria. ◎: The average value is 1.0 point or more and less than 1.5 points. 〇: The average value is 1.5 points or more and less than 2.5 points. △: The average value is 2.5 points or more and less than 3.5 points. ×: The average value is 3.5 or more. It was determined that △, ○, and ◎ are practical.

[0069] ※3: Virus inactivation test <Test method> Add 0.1 mL of virus solution adjusted to 10 8 TCID 50 / mL to 0.9 mL of each liquid detergent composition in a test tube, mix with a mixer to prepare a mixed solution, and let it act at 25 °C for 30 seconds. Also, assuming organic dirt, add 0.1 mL of virus solution containing 5% meat extract (manufactured by Nacalai Tesque) adjusted to 10 8 TCID 50 / mL to 0.9 mL of each liquid detergent composition in a test tube, mix with a mixer to prepare a mixed solution, and let it act at 25 °C for 30 seconds. After the action, sample 0.1 mL of the above mixed solution, add it to 9.9 mL of the action stopping solution (cell growth solution containing 2% sodium thiosulfate, 0.2% lecithin, and 1.5% polysorbate 80), dilute 100-fold, and stop the action of various extracts on the virus. This was used as the sample stock solution for measuring the virus infectivity titer for measuring the infectivity titer. Similarly, a test was conducted using phosphate buffered saline (hereinafter sometimes abbreviated as PBS) instead of the extract as a control. Incidentally, phosphate buffered saline was prepared by mixing four salts, 8 g of sodium chloride, 0.2 g of potassium chloride, 1.44 g of disodium hydrogen phosphate, and 0.24 g of potassium dihydrogen phosphate, dissolving them in 900 mL of ultrapure water, adjusting the pH to 7.4 with hydrochloric acid, and then making up to 1 L and sterilizing by autoclave.

[0070] Three types of viruses, feline calicivirus, murine norovirus, and influenza virus, were used in the above test. Dilute each sample stock solution for measuring the virus infectivity titer 10-fold with PBS8 After preparing dilution solutions by performing 10-fold serial dilutions up to a certain point, 50 μL of the undiluted sample for measuring the infectious titer and 50 μL of each dilution solution at each dilution step were inoculated into a 96-well plate, along with 50 μL of cell suspension suspended in Dulbecco's modified Eagle's Medium (DMEM) containing 5% fetal bovine serum (FBS). Subsequently, the samples were cultured in a carbon dioxide incubator at 37 °C and 5% CO2 for 4 days. After culturing, the presence or absence of CPE (cytopathic effect) due to virus growth was observed under an inverted microscope, and the virus infectious titer (TCID 50 / mL) was determined using the Reed-Muench method and evaluated according to the following criteria.

[0071] <Evaluation Criteria> 1 point: Log reduction of the virus infectious titer is 4 or more. 2 points: Log reduction of the virus infectious titer is 3 or more but less than 4. 3 points: Log reduction of the virus infectious titer is 2 or more but less than 3. 4 points: Log reduction of the virus infectious titer is less than 1. The decrease in the virus infectious titer for each virus was evaluated in terms of points, and the average value of the points for the three viruses was determined. The virus inactivation effect was evaluated according to the following criteria.

[0072] ◎: The average value is 1.0 or more but less than 1.5 points. 〇: The average value is 1.5 or more but less than 2.5 points. △: The average value is 2.5 or more but less than 3.5 points. ×: The average value is 3.5 or more. And △, 〇, and ◎ were determined to be practical.

[0073] ※4: Foam retention test <Test method> This test was carried out by the Ross-Miles method (JIS K 3362). Each liquid detergent composition was foamed at 25°C, and the foam height at the start of measurement and after 5 minutes was measured. The foam retention rate was calculated according to the following formula (2) from the foam height (F1) after 5 minutes with respect to the foam height (F0) at the start of measurement, and the foam retention was evaluated according to the following criteria. A commercially available foam pump was used for foaming the liquid detergent composition. (Formula 2) Foam retention rate (%) = F1 / F0 × 100 ····· (2)

[0074] <Evaluation criteria> 〇: The foam retention rate is 90% or more. △: The foam retention rate is 80% or more and less than 90%. ×: The foam retention rate is less than 80%, or sufficient foaming cannot be obtained. And △ and ○ were judged to be practical.

[0075] ※5: Rinsability test <Test method> This test was conducted on 10 panelists who had received training on the evaluation of rinsability. Each panelist took 1 push (about 1 mL) of each liquid detergent composition placed in a commercially available foam pump, washed their hands for 30 seconds, then rinsed with tap water for 30 seconds, and evaluated the rinsability according to the following criteria based on the speed of rinsing and the lack of stickiness on the hands after rinsing.

[0076] <Evaluation criteria> 4 points: Good rinsability 3 points: Slightly good rinsability 2 points: Slightly poor rinsability 1 point: Poor rinsability The rinsability was evaluated by points and the average value was obtained, and the rinsability was evaluated according to the following criteria.

[0077] ◎: The average value is 3.4 points or more. 〇: The average value is 2.7 points or more and less than 3.4 points. △: The average value is 2.0 points or more and less than 2.7 points. ×: The average value is less than 2.0 points. And △, ○, and ◎ were judged to be practical.

[0078] ※6: Skin irritation test <Test method> This test was conducted on 10 panelists for each example. The panelists in this test did not conduct the detergency test, rinsability test, and skin irritation test of the liquid detergent compositions described in other examples during the test. Each panelist took 1 mL of the liquid detergent composition in their hand and performed handwashing for 30 seconds, then rinsed with tap water for 30 seconds. This handwashing operation was repeated 3 times a day for 7 days. From the condition of each panelist's hand after 7 days, the skin irritation was evaluated according to the following criteria.

[0079] <Evaluation criteria> 4 points: No roughness of the hands 3 points: Slight roughness of the hands can be seen 2 points: Roughness of the hands can be seen here and there 1 point: Considerable roughness of the hands can be seen The skin irritation was evaluated by scores and the average value was obtained, and the skin irritation was evaluated according to the following criteria.

[0080] ◎: The average value is 3.5 points or more. 〇: The average value is 3.0 points or more and less than 3.5 points. △: The average value is 2.5 points or more and less than 3.0 points. ×: The average value is less than 2.5 points. It was determined that △, 〇, and ◎ are practical.

[0081] ※7: Storage stability test <Test method>

[0082] 200 mL of each liquid detergent composition was taken in a 250 mL transparent polypropylene container, covered, and stored in a constant temperature bath at -5 °C, 25 °C, and 40 °C and left standing. After 1 month, the appearance was observed.

[0083] <Evaluation criteria> 〇: No separation or turbidity is observed and it is stable. △: There is no overall separation, and slight turbidity is observed, but there is no problem in use. ×: Separation or turbidity is observed. and determined that △ and ○ are practical.

[0084] [Table 1]

[0085] [Table 2]

[0086] [Table 3]

[0087] [Table 4]

[0088] [Table 5]

[0089] [Table 6]

[0090] [Table 7]

Claims

1. As the (A-α) component, an alkyltrimethylammonium salt, As the (A-β) component, an alkyldimethylbenzylammonium salt, As the (B) component, a pH adjuster, As the (C) component, at least one selected from nonionic surfactants and amphoteric surfactants, As the (D) component, a polyhydric alcohol As the (E) component, water, A skin alkaline liquid detergent composition containing the above, wherein the total amount of the (A-α) component and the (A-β) component is less than 0.6% by mass, and the mass ratio (A-α) / (A-β) of the mass of the (A-α) component to the mass of the (A-β) component is 0.01 or more and less than 1, and the pH at 25 °C is 8.0 or more and 12.0 or less.

2. The skin alkaline liquid detergent composition according to Claim 1, wherein the mass ratio (C component) / (A component) of the mass of the (C) component to the mass of the (A) component is 0.1 or more and 150 or less.

3. The skin alkaline liquid detergent composition according to Claim 1 or 2, containing as the (B) component at least one selected from alkali metal hydroxides, alkali metal silicates, alkanolamines, alkali metal carbonates, alkali metal phosphates, and organic acid salts.

4. The skin alkaline liquid detergent composition according to Claim 1 or 2, containing as the (C) component at least one selected from polyoxyalkylene alkyl ethers, alkyl glucosides including alkyl polyglucosides, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkylamino (mono- or di-) propionates, and alkyldimethylamine oxides.

5. The skin alkaline liquid detergent composition according to Claim 1 or 2, containing as the (D) component at least one selected from ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol.

6. The skin alkaline liquid detergent composition according to Claim 1 or 2, wherein the skin alkaline liquid detergent composition is a finger liquid detergent.

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