Wireless power feeding light emitting device, light emitting device, and method for emitting light

Abstract

To provide a wireless power feeding light emitting device that can emit a sufficient volume of light over a wide range of a target site while being disposed in a living body and is reduced in a diameter of an outer diameter size, thereby allowing sufficient circulation of body fluid.SOLUTION: A wireless power feeding light emitting device for partially irradiating a living body with light from the inside of the living body includes: a stent; a surface light-emitting element formed in a surface of the stent; and a power receiving part electrically connected to the surface light-emitting element.SELECTED DRAWING: Figure 4

Description

Technical Field

[0001] The present invention relates to a wireless power supply type light irradiation device, a light irradiation apparatus, and a light irradiation method.

Background Art

[0002] Light can be used to treat a wide variety of diseases. When light is used alone to treat a disease, this treatment is called radiotherapy. When light is used together with a drug, this treatment is called photodynamic therapy (PDT). In addition, photoimmunotherapy is also known, in which an antibody conjugated with a photosensitive substance is collected in cancer cells and the cancer is treated by irradiating the cells with light. These therapies can be used to treat various skin diseases and internal diseases (hereinafter referred to as "internal diseases" in this specification).

[0003] When attempting to treat an internal disease using light, there is a problem that when irradiating light from outside the body, a sufficient amount of light does not reach organs in the body. In addition, when increasing the intensity of light irradiation from outside the body, there is a problem that light causes an invasion to the living body, such as concerns about skin burns and concerns about the effects of light irradiation on organs other than the affected part. Therefore, in order to address these problems, a method has been proposed in which a planar light emitter is attached to the organ to be treated and light irradiation is directly performed on the organ. For example, Patent Document 1 describes a method in which a planar light irradiation device is implanted (synonymous with embedded) in the living body and light irradiation is performed by wirelessly supplying power from outside the body. According to this method, since the light irradiation device can be directly attached to the affected part such as the liver and light irradiation can be performed, efficient and effective treatment can be performed. In addition, since there is no need to implant a battery or a power source in the body, there is also an advantage that the weight of the device implanted in the body can be reduced while avoiding the invasion of harmful substances contained in the battery or the power source into the living body.

[0004] However, there was a problem that the planar light irradiation device could only be applied when it was easy to attach it to the organ to be treated or its vicinity. There are various organs in the human body, and there are also many types of tubes connecting the organs. Tumors often occur in the tubes, and cholangiocarcinoma, one of them, is an example that is difficult to treat surgically. In addition, tumors also occur in various parts such as the airway, large intestine, and ureter. For these treatments, so-called standard treatments such as surgery, anticancer drugs, and radiation are performed. However, since the side effects are large for humans, invasive low-treatment methods using light such as photodynamic therapy and photoimmunotherapy have been developed. However, for example, when trying to apply the above planar light irradiation device to a tumor in such a tube, there is not enough space for attachment, and the attachment surgery in a narrow space is extremely difficult. In addition, when it is desired to perform light irradiation treatment on a tumor of an organ near the tube, there is also a problem that the tube and the organ get in the way and the planar light irradiation device cannot be attached to an appropriate position.

[0005] On the other hand, as a light irradiation device that is not planar, a stent-type therapeutic device has been proposed. A medical stent is used to insert into a tube to expand the tube and ensure the flow of body fluids and air when stenosis occurs due to a tumor or the like. An ordinary stent only has the role of expanding the stenotic part, and it is generally difficult to endow it with a therapeutic function. Among such circumstances, as a stent-type therapeutic device mainly aimed at endowing a therapeutic function, the one described in Patent Document 2 has been proposed. This light-emitting therapeutic device is configured by winding a power receiving coil, a resonance capacitor, and a flexible wiring board on which a plurality of LEDs (light emitters) are arranged at a predetermined interval around the outer periphery of a tube stent. When this light-emitting therapeutic device is inserted into the living body and the magnetic flux applied from an external power transmission means is changed, the power receiving coil generates electricity and the LEDs emit light, and the photosensitive substance attached to cancer cells by an antigen-antibody reaction is irradiated with light. Accordingly, it is said that photodynamic immunotherapy can be performed by the light-emitting therapeutic device arranged in the living body. However, in this light-emitting therapeutic device, since a plurality of LEDs, which are point light sources, are arranged at intervals, the light irradiation area at the affected part is limited to the radiation area from the point light sources, and there is a problem that uniform and effective light irradiation cannot be performed on the tumor part. Further, since the power receiving coil, the resonance capacitor, and the plurality of LEDs are all mounted on the flexible wiring board, each component has an increased thickness by the thickness of the flexible wiring board, making it difficult to reduce the outer diameter size, and there is also a drawback that a sufficient flow path for body fluids cannot be ensured.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0007] The problem to be solved by the present invention is to provide a wireless power supply type light irradiation device that can uniformly irradiate light with a sufficient amount of light over a wide range of a target site in a state of being disposed in a living body, and can achieve a reduction in the outer diameter size to enable sufficient circulation of body fluid.

Means for Solving the Problem

[0008] As a result of intensive studies by the present inventors to solve the above problems, by adopting a configuration in which a planar light emitting element is wound around the outer periphery of a stent and powered wirelessly, it is possible to uniformly irradiate light with a sufficient amount of light to a target affected part in a state of being disposed in a living body, and a wireless power supply type light irradiation device that can achieve a reduction in the outer diameter size to enable sufficient circulation of body fluid has been found.

[0009] The present invention, which is a specific means for solving the above problems, and a preferred embodiment of the present invention are as follows. [1] A wireless power supply type light irradiation device having a stent, a planar light emitting element formed on the surface of the stent, and a power receiving part electrically connected to the planar light emitting element, and being used for irradiating a part of the living body from the living body. [2] The wireless power supply type light irradiation device according to [1], wherein the planar light emitting element is formed on a flexible substrate. [3] The wireless power supply type light irradiation device according to [1] or [2], wherein the planar light emitting element is an organic electroluminescence element. [4] The wireless power supply type light irradiation device according to any one of [1] to [3], wherein at least a part of the planar light emitting element covers 25% or more of the outer periphery of the stent. [5] The wireless power supply type light irradiation device according to any one of [1] to [4], wherein the planar light emitting element is formed over a length of 2 mm or more in the longitudinal direction of the stent. [6] The wireless power supply type light irradiation device according to any one of [1] to [5], wherein the power receiving part has a receiving coil and a receiving circuit. [7] The wireless power supply type light irradiation device according to [6], wherein the receiving coil is formed on the surface of the stent. [8] The wireless power supply type light irradiation device according to [7], wherein a winding coil is formed on the surface of the stent as the receiving coil. [9] The wireless power supply type light irradiation device according to [7], wherein a spiral coil is formed on the surface of the stent as the receiving coil.

[10] The wireless power supply type light irradiation device according to [7], wherein a winding coil and a spiral coil are formed on the surface of the stent as the receiving coil.

[11] The wireless power supply type light irradiation device according to any one of [1] to

[10] , wherein the stent is formed of plastic.

[12] The wireless power supply type light irradiation device according to any one of [1] to

[11] , which has an illuminance sensor.

[13] The wireless power supply type light irradiation device according to any one of [1] to

[12] , which has a temperature sensor.

[14] The wireless power supply type light irradiation device according to any one of [1] to

[13] , wherein the light emission of the planar light emitting element reaches 360 degrees around the outer circumference of the stent.

[15] A light irradiation device including the wireless power supply type light irradiation device according to any one of [1] to

[14] and a power transmitter.

[16] A light irradiation method of supplying power from the power transmitter of the light irradiation device according to

[15] to the power receiving part of the wireless power supply type light irradiation device, and the power receiving part supplies power to the light emitting element to cause the light emitting element to emit light.

Advantages of the Invention

[0010] According to the present invention, a wireless power supply type light irradiation device capable of irradiating a sufficient amount of light in a planar shape from inside a living body to a part of the living body and reducing the outer diameter size to enable sufficient circulation of body fluid is realized.

Brief Description of the Drawings

[0011]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Embodiments for Carrying Out the Invention

[0012] Hereinafter, the present invention will be described. The description of the constituent elements described below may be based on representative embodiments or specific examples of the present invention, but the present invention is not limited to such embodiments or specific examples. In this specification, the numerical range represented by "~" means a range including the numerical values described before and after "~" as the lower limit value and the upper limit value.

[0013] <Wireless power supply type light irradiation device> The wireless power supply type light irradiation device of the present invention has a stent, a planar light emitting element formed on the surface of the stent, and a power receiving unit electrically connected to the planar light emitting element, and is used for irradiating light from inside the living body to a part of the living body. It is a wireless power supply type light irradiation device. With this configuration, the wireless power supply type light irradiation device of the present invention can irradiate a part of the living body with a sufficient amount of light in a planar manner from inside the living body. In addition, at least the planar light emitting element can be formed on the surface of the stent without being mounted on a mounting substrate, so that the outer diameter size of the wireless power supply type light irradiation device can be reduced, and it is easy to secure an inner diameter of a flow path that enables sufficient circulation of body fluid.

[0014] Hereinafter, preferred embodiments of the wireless power supply type light irradiation device of the present invention will be described. The wireless power supply type light irradiation device of the present invention is used for irradiating light from inside the living body to a part of the living body. In other words, it is used for emitting light inside the living body. As a use for irradiating light from inside the living body to a part of the living body, it is preferably a use for emitting light inside the living body rather than the outer skin of the living body. For example, it is particularly preferably for implantation into the living body. The method of implanting into the living body is not particularly limited, and it can be performed by a known stent placement technique or surgery using an endoscope, a guide wire, a catheter, or the like. The wireless power supply type light irradiation device of the present invention is preferably for treating the living body, and more preferably for treating the internal organs of the living body. In the present invention, the living body is preferably a human or an animal. Examples of the animal include mammals (such as mice, rats, guinea pigs, pigs, cows, etc.). In particular, when a doctor treats a human or a veterinarian treats an animal, the wireless power supply type light irradiation device and the light irradiation device of the present invention can be preferably used. Also, the light emitted from the wireless power supply type light irradiation device may be irradiated to any part of the living body. In the present invention, the light emitted from the wireless power supply type light irradiation device implanted in the living body is preferably irradiated to the tissue around the lumen of the living body or the target affected part in the internal organs.

[0015] The wireless power supply type light irradiation device may be implanted in any part of a living body. In a preferred embodiment of the present invention, the wireless power supply type light irradiation device is implanted into the lumen of a living body. Thereby, when there are abnormalities such as tumors, inflammations, or structural abnormalities due to various causes near the lumen, these can be effectively treated. Applicable tubular organs include, in the digestive system organs, the esophagus, stomach, small intestine, and large intestine; in the respiratory system, the trachea and bronchi; in the circulatory system, arteries and veins; in the urinary system, the ureter and urethra; in the genital system, the seminiferous tubules and vas deferens in males, and the fallopian tubes in females; and in the bile duct, the gallbladder, intrahepatic bile ducts, and bile duct, etc. The wireless power supply type light irradiation device may be implanted into any lumen, but preferably into the biliary tract and airway. When the wireless power supply type light irradiation device is implanted near the lumen of a living body or organs such as the internal organs (liver, pancreas, heart, and lungs), the outer diameter, length, light emitting area, and shape of the wireless power supply type light irradiation device can be adjusted according to the inner diameter and shape of the lumen and the shape of the organ. Moreover, it is preferable that the wireless power supply type light irradiation device used in the present invention is flexible from the viewpoint that it can be bent and used according to the shape of any living body.

[0016] The maximum outer diameter (the outer diameter of the part with the largest outer diameter) and the longitudinal length of the wireless power supply type light irradiation device can be appropriately selected according to the type of living body to which the device is applied, the shape of the implantation site (for example, the lumen), the state of the affected part, etc. The maximum outer diameter of the wireless power supply type light irradiation device can be selected, for example, from the range of 2 to 31 mm, and the longitudinal length can be selected, for example, from the range of 3 to 300 mm, but it is not limited to these ranges and can be appropriately selected according to the site where the wireless power supply type light irradiation device is implanted. For example, the maximum outer diameter can be within the range of 2 to 10 mm, within the range of 10 to 20 mm, or within the range of 20 to 31 mm, and the longitudinal length can be within the range of 3 to 10 mm, within the range of 10 to 100 mm, or within the range of 100 to 300 mm.

[0017] The light irradiation device and the light irradiation method of the present invention are applicable to all tubular organs that can cause stenosis. Specific lesions include cancer (e.g., cholangiocarcinoma, lung cancer (bronchogenic carcinoma), ureteral cancer, fallopian tube cancer), inflammatory diseases (e.g., cholangitis, pancreatitis), vascular diseases (e.g., arteriosclerosis, deep vein thrombosis), infectious diseases (e.g., urethritis, cholangitis), autoimmune diseases (e.g., primary sclerosing cholangitis), structural problems (e.g., prostatic hyperplasia, biliary atresia), and postoperative symptoms including trauma and catheter operations (e.g., scar formation of tubular organs due to injury, arterial stenosis after coronary angioplasty of the heart).

[0018] Hereinafter, a more preferable embodiment of the configuration of the wireless power supply type light irradiation device will be described together with the preferable embodiments of each member. As the material of each member, in addition to the preferable embodiments described below, known materials may be used. For example, the materials of the organic EL element described in paragraphs

[0031] to

[0044] of Japanese Patent Application Laid-Open No. 2013-140718 can be used for the wireless power supply type light irradiation device of the present invention, and the contents of this publication are incorporated herein by reference.

[0019] In the wireless power supply type light irradiation device of the present invention, the planar light emitting element is formed on the surface of the stent, and it is preferable to irradiate the periphery of the stent. The power receiving part may be formed on the surface of the stent and electrically connected to the planar light emitting element, or may be installed at a position different from the stent and electrically connected to the planar light emitting element via an electric wire. Hereinafter, the mode in which the power receiving part is formed on the stent surface and electrically connected to the planar light emitting element is referred to as "the first mode", and the mode in which the power receiving part is installed at a position different from the stent and electrically connected to the planar light emitting element via an electric wire is referred to as "the second mode".

[0020] <The first mode> The wireless power supply type light irradiation device of the first mode has a stent, a planar light emitting element, and a power receiving part electrically connected to the planar light emitting element, and both the planar light emitting element and the power receiving part are formed on the surface of the stent. Hereinafter, each part constituting the first mode will be described.

[0021] [Stent] The stent used in the present invention is preferably a tubular type stent. The material of the stent can be used without particular limitation as long as it can pass through a magnetic field. However, it is preferably a material that can pass through a magnetic field and has flexibility and stretchability, and plastics can be preferably used. By using plastic as the material of the stent, the wireless power supply type light irradiation device can be configured to be flexible and can be bent according to the shape of the implantation site. In a preferred embodiment of the present invention, the stent is a tubular type stent (tube stent) made of plastic. Specific examples of the plastic used for the stent include polyolefin resins such as polyethylene and polypropylene, fluororesins such as polyurethane and polytetrafluoroethylene, and silicone resins. In addition, a mesh type stent made of a metal such as stainless steel that can be expanded after being inserted into the affected part, which is a material that is difficult to absorb a magnetic field, can also be used.

[0022] The outer diameter, wall thickness (thickness of the tube wall), and length of the stent can be appropriately selected according to the type of living body to which the wireless power supply type light irradiation device is applied, the shape of the site (e.g., lumen) where the device is implanted, the state of the affected part, etc. The outer diameter of the stent can be selected, for example, from the range of 2 to 31 mm, and the length of the stent can be selected, for example, from the range of 3 to 300 mm. However, the size of the stent is not limited to these ranges and can be appropriately adjusted according to the site where the device is implanted. Commercially available stents may be used for the stent. For example, when the site where the stent is implanted is the bile duct, an appropriate size can be selected from known bile duct stents, and when the site where the stent is implanted is the trachea, an appropriate size can be selected from known trachea stents. In addition, the ends of the stent may be formed into a mushroom type or a pigtail type.

[0023] [Planar light emitting element] The "planar light-emitting element" in the present invention is a light-emitting element formed on the surface of a stent, which forms a planar shape when removed from the stent and spread out, and means a light-emitting element that emits light by power supply. Here, "planar" means a shape having a main surface (the surface with the largest area among the surfaces of the planar light-emitting element) that spreads in two dimensions, and the area of the main surface is preferably 10 mm 2 or more, for example, 10 to 1000 mm 2 is. For example, within the range of 10 to 50 mm 2 or within the range of 50 to 100 mm 2 or within the range of 100 to 1000 mm 2 can be. The planar light-emitting element may be a light-emitting element formed by winding a planar light-emitting element manufactured separately from the stent around the stent, or may be a light-emitting element having a layer formed with the stent as a base material.

[0024] The planar light-emitting element is preferably formed on the surface of the stent such that the light-emitting surface faces outward (opposite to the surface of the stent). Thereby, by implanting the wireless power supply type light irradiation device into the living body and supplying power, the surrounding tissue can be irradiated with light in a planar manner. The irradiation intensity of the planar light-emitting element is, for example, in the range of 0.01 to 80 mW / cm 2 and may be in the range of 0.1 to 20 mW / cm 2 . When the living body is a human, an irradiation intensity of 0.5 to 5 mW / cm 2 is appropriate. The irradiation intensity of the planar light-emitting element may be constant or variable during treatment. The irradiation intensity of the planar light-emitting element can be adjusted by controlling the applied voltage or applied current.

[0025] The planar light-emitting element may be formed over the entire length of the stent in the longitudinal direction, or may be formed in a region excluding both ends of the stent. Further, the planar light-emitting element is preferably formed over 2 mm or more in the longitudinal direction of the stent, and more preferably formed over 3 mm or more. For example, it can be within the range of 2 to 10 mm, within the range of 10 to 50 mm, or within the range of 50 to 100 mm. In the following description, the range in which the planar light-emitting element is formed in the longitudinal direction of the stent is referred to as the "planar light-emitting element formation region". In the planar light-emitting element formation region, the planar light-emitting element may be formed over the entire circumference of the outer peripheral surface of the stent so as to emit light over 360 degrees of the outer periphery of the stent, or may be formed in a region corresponding to a part of the circumference of the outer peripheral surface. In other words, the planar light-emitting element may be formed on the surface of the stent so as to form a cylindrical shape without a notch, or may be formed on the surface of the stent so as to form a shape with a part of the cylinder cut out (a cross-sectional arc shape). In the aspect where the planar light-emitting element is formed in a region corresponding to a part of the circumference of the outer peripheral surface of the stent, the ratio of the formation region of the planar light-emitting element in the circumference of the outer peripheral surface can be changed according to the location and size of the lesion, and it is possible to selectively irradiate light to the lesion part. Thereby, the treatment effect can be maximized while reducing the damage to normal cells. Therefore, the ratio of the formation region of the planar light-emitting element in the circumference of the outer peripheral surface is preferably 25 to 100%, and for example, it can be within the range of 25 to 50%, within the range of 50 to 80%, or within the range of 80 to 100%.

[0026] Also, the number of planar light-emitting elements formed on the surface of the stent may be one or two or more. In a preferred aspect of the present invention, the number of planar light-emitting elements formed on the stent is one.

[0027] Examples of the planar light-emitting element include an organic light-emitting element having at least one organic layer composed of an organic semiconductor. Examples of the organic light-emitting element include an organic electroluminescence element (also referred to as an organic light-emitting diode: OLED), a polymer light-emitting diode (PLED), an organic electrochemiluminescence cell (OLEC), an electroluminescence element (QLED) using quantum dots as a light emitter, etc., and preferably an organic electroluminescence element. The organic electroluminescence element exhibits excellent planar light-emitting properties and can be imparted with excellent flexibility by selecting materials. Hereinafter, as a representative example of the planar light-emitting element, the organic electroluminescence element will be described.

[0028] (organic electroluminescence element) The organic electroluminescence element has a pair of electrodes and an organic layer including at least a light-emitting layer disposed between the pair of electrodes, and is an element in which light emission occurs in the light-emitting layer by applying a voltage between the pair of electrodes. Hereinafter, each part constituting the organic electroluminescence element will be described in detail.

[0029] - Substrate - In the present invention, since the stent functions as a base material of the planar light-emitting element, the organic electroluminescence element as the planar light-emitting element may or may not have a substrate. When the organic electroluminescence element has a substrate, the substrate is preferably a flexible substrate in order to facilitate winding of the element around the stent and to impart flexibility to the wireless power supply type light irradiation device.

[0030] A plastic substrate having a medical grade can be used for the substrate of the organic electroluminescence element. For example, examples of the medical thermoplastic polymer material include polyethylene terephthalate, polyurethane, polymethyl methacrylate, polycarbonate, cycloolefin polymer, polyphenyl sulfone resin and its analogs, etc. Also, a stretchable (preferably further flexible) material can be used. The stretchability enhances the adhesion to the living body formed from the curved surface. For example, natural rubber, urethane rubber, silicone rubber, etc., which are elastomers, can use known ones. Furthermore, in order to make the surface of the so-called substrate hydrophilic and improve the adhesion to the living body, a biocompatible film such as a substrate with a hydrogel surface grafted with a hydrophilic monomer can be used. It is preferable that the substrate is a biocompatible film. It is preferable that the substrate contains a thermoplastic resin as a main component. The main component refers to a component that occupies 50% by mass or more of the total mass of the substrate. It is preferable that the substrate contains 80% by mass or more of the thermoplastic resin, and more preferably 90% by mass or more. Also, the substrate may be a single layer or a laminate of two or more layers. It is preferable that the substrate is a single layer. The substrate may have a layer that does not contain a thermoplastic resin as a main component, such as a layer mainly composed of an inorganic film. It is preferable to use a flexible substrate on which a barrier layer for suppressing water vapor and oxygen permeability is formed for these substrates. Generally, polymer materials have high moisture and oxygen permeability and often damage light-emitting elements using organic semiconductors. Therefore, it is important to form a light-emitting element on a substrate with a barrier layer formed, and also use a substrate with low moisture and oxygen permeability for the encapsulation film. Specific examples of the barrier layer include examples of laminating an inorganic substance and an organic substance, examples formed substantially only of an inorganic substance, etc., and known ones are widely used. Among them, the water vapor transmission rate (WVTR) is 10 -2 Unit: g / m 2 / day or less (the same below) is preferable, 10 -4 is more preferable, and 10 -5 or less is particularly preferably used. The WVTR value can be measured by bringing an existing measuring device (for example, DeltaPalm). There is no limitation on the thermoplastic resin that is the main component of the above substrate. Also, a curable resin may be used for the substrate, but when using a curable resin, it is preferable to control the curing or the content in the substrate to such an extent that the flexibility is not completely lost.

[0031] In the present invention, the thickness of the substrate is preferably 5 to 200 μm, more preferably 10 μm to 125 μm, and particularly preferably 10 μm to 80 μm. When the thickness of the film substrate is reduced, the rigidity of the film can be decreased, and it becomes easier to wind the organic electroluminescence element around the stent.

[0032] -Electrode- A pair of electrodes act as an anode and a cathode. The pair of electrodes used in the present invention is preferably planar. Thereby, by sequentially forming an organic layer and the other electrode on one surface of one of the pair of electrodes, an organic electroluminescence element having a planar shape as a whole can be easily formed. Further, the pair of electrodes preferably has flexibility. Thereby, it becomes easier to wind the organic electroluminescence element around the stent, and flexibility can be imparted to the wireless power supply type light irradiation device. There is no particular limitation on the material used for the electrode, and a material used for a known electrode can be used. For example, conductive oxide materials such as ITO (Indium Tin Oxide) and IZO (Indium Zinc Oxide), and electrodes such as silver and aluminum can be mentioned. The electrode is preferably a transparent electrode. ITO is preferable as the anode, and aluminum is preferable as the cathode. Further, a light emitting element that emits light on both sides with the electrodes on both sides of the substrate being transparent electrodes can also be used. As the anode, ITO having a work function of about 5.0 eV is more preferable than silver having a work function of about 4.3 eV from the viewpoint that holes can be efficiently injected into the hole injection layer and the driving voltage can be lowered. Here, when fabricating a transparent electrode on the surface of a flexible substrate, it is preferable to fabricate an electrode of a transparent conductive film with as low a resistance as possible so that the voltage drop is small. ITO, which is generally used as an anode, is formed by sputtering. When using a flexible substrate, since the ITO sputtered at a high temperature as formed on a glass substrate cannot be annealed to enhance crystallization, the ITO used for the anode usually has lower crystallinity and a tendency to have higher resistance than normal.

[0033] The formation of transparent conductive films is known for various materials and processes. When using a plastic substrate, in some cases, after forming the above-mentioned water vapor barrier film (such as SiO or SiN) on the plastic substrate, a transparent oxide such as ITO or IZO is laminated. After forming the above-mentioned water vapor barrier film on a plastic substrate, silver nanowires, silver nanoparticles, or copper nanoparticles may be fabricated in a stripe, mesh, or honeycomb shape and laminated with a transparent conductive film such as ITO. It is also possible to first form a stripe electrode such as silver and then sputter a transparent conductive film such as ITO thereon. In these cases, for example, the stripe electrode may be formed with a width of 0.1 mm and a thickness of 50 nm at a 1 mm pitch. In some cases, the whole may be covered with a conductive polymer such as polythiophene instead of ITO. Furthermore, attempts have been made to form a thin-film conductive layer using carbon nanotubes, graphene, etc. to achieve both flexibility and low resistance, and these known technologies can be used.

[0034] -Light-emitting layer- The light-emitting layer is an organic layer in which carriers injected from a pair of electrodes recombine to generate light emission. As materials for the light-emitting layer, fluorescent and phosphorescent organic semiconductors can be used. There is no particular limitation on the material of the light-emitting layer. Various light-emitting materials can be selected according to the disease situation. For example, blue light of about 400 to 500 nm may be effective for skin diseases such as skin cancer and acne. When a photochemotherapeutic agent is used in combination, any material having a light emission maximum at 500 to 700 nm, which is the absorption of the porphyrin derivative generated in the body, can be used without limitation. Also, in vivo, the wavelength range where hemoglobin and water have large absorption is difficult for light to penetrate into the body. Therefore, for light irradiation from outside the body to bring about a deeper penetration effect in the body, light with a long wavelength of 600 nm or more is desirable. To avoid the absorption of light by water in biological tissues, a light-emitting material having a light emission peak up to about 1200 nm is desirable. However, photosensitizing substances typified by porphyrin derivatives also have absorption in the blue and green regions, and by utilizing this absorption, various lights other than light emission in the red region of 600 nm or more can be utilized. As the material of the light-emitting layer, it is preferable to use a low molecular compound including a vacuum deposition type oligomer, a high molecular compound, or a coating type low molecular compound. As the low molecular compound, known compounds can be used without limitation. (For example, materials described in Zhigang Li, hong Meng, organic Lighit Emitting Materials and Devices, Taylor & Francis) As the high molecular compound, for example, a high molecular red phosphorescent material manufactured by Sumitomo Chemical can be mentioned. As the coating type low molecular compound, 1,3-bis(carbazol-9-yl)benzene (mCP) etc. can be mentioned as the host material of the light-emitting layer, and mCP can be used in combination with a red phosphorescent material (Bis(2-benzo[b]thiophene-2-yl-pyridine)(acetylacetonate)iridium(III), (Ir(btp)2(acac))) etc. used as a dopant. These materials are not limited, and known light-emitting materials can be widely utilized.

[0035] -Other configurations- The organic electroluminescence device may have organic layers other than the light-emitting layer. Examples of the organic layers other than the light-emitting layer include a hole injection layer, a hole transport layer, an electron transport layer, an electron injection layer, a hole blocking layer, an electron blocking layer, and the like. There is no particular limitation on the materials used for these organic layers, and known materials can be used. Further, the organic electroluminescence device may be sealed. For the description of the sealing material, reference can be made to the description in the column of "Sealing Material" below. As for the element structure, there are so-called bottom emission type, top emission type, and double-sided emission type as described above, and various configurations such as a structure in which an anode / light-emitting layer / cathode or a cathode / light-emitting layer / anode is laminated from the substrate are being studied, but the present invention can be used without particular limitation.

[0036] [Power receiving part] The power receiving part of the first aspect is formed on the surface of the stent and is electrically connected to the surface light-emitting element. The power receiving part has a function of receiving wirelessly transmitted energy and generating electricity. The electric power generated in the power receiving part is supplied to the surface light-emitting element to cause the surface light-emitting element to emit light. The power receiving part preferably has a receiving antenna. As the receiving antenna, a receiving coil is preferable. It is preferable that the power receiving part has a receiving coil and a receiving circuit, and the receiving circuit converts alternating current to direct current. However, the power receiving part is not limited to the mode having a coil as long as it is powered by the power transmitter described later. Also, the receiving coil and the receiving circuit formed on the surface of the stent may be one or two or more. When two or more receiving coils or receiving circuits are formed on the surface of the stent, the two or more receiving coils may be the same as or different from each other, and the two or more receiving circuits may be the same as or different from each other.

[0037] -Receiving coil- The receiving coil generates an induced current due to a change in magnetic flux applied from an external power transmitter. The receiving coil used in the first aspect is formed on the surface of the stent. Examples of the receiving coil include a wound coil (solenoid coil) formed by winding an electric wire around the stent to form a cylindrical wound body, and a coil substrate having a coil conductive film pattern formed on the surface of a flexible substrate. The coil conductive film pattern is, for example, a spiral conductive film pattern (hereinafter sometimes referred to as a "spiral coil"). The coil substrate constitutes the receiving coil of the first aspect, for example, by being wound around the stent to form a cylindrical body of the coil substrate.

[0038] The electric wire of the wound coil is one in which the conductive wire is coated with an insulating coating such as an enamel coating. As the material of the conductive wire, it can be appropriately selected from known conductive materials, and it is preferable to select a conductive material with low resistance. For example, low-resistance metals such as copper, silver, and alloys containing at least one of copper and silver can be preferably used. The thickness of the electric wire used for the wound coil is not particularly limited, but it can be selected, for example, from the range of 0.1 to 0.5 mm. Thereby, while suppressing the diameter of the wound coil to be small, the resistance of the coil wire can be lowered and the Q value can be increased. The axial length of the wound coil preferably gives higher power reception efficiency when it is longer, but in order to avoid excessive increase in the device length, it is preferably selected from the range of, for example, 10 to 30 mm.

[0039] For the description of the conductive material used for the conductive film pattern of the coil substrate and preferred examples, reference can be made to the description of the conductive seat material used for the wound coil. As the flexible substrate of the coil substrate, it can be appropriately selected from known flexible substrates commonly used for flexible printed circuits (FPC). For example, substrates using films such as PET (polyethylene terephthalate) film, PEN (polyethylene naphthalate) film, and PI (polyimide) film can be mentioned.

[0040] The power reception efficiency of the coil substrate can be controlled by the thickness and number of turns of the conductive film pattern. The thickness of the line of the conductive film pattern can be selected, for example, from the range of 50 to 500 μm, and the number of turns of the conductive film pattern can be selected, for example, from the range of 3 to 10. The conductive film pattern may be formed only on one surface of the flexible substrate for the coil substrate, but if the conductive film pattern is formed on both surfaces of the flexible substrate, the resistance can be reduced and a higher quality factor Q can be obtained. The connection between the conductive film patterns formed on both surfaces of the flexible substrate may be in series or in parallel.

[0041] As one aspect of the coil substrate, a coil substrate formed with a rectangular spiral coil is shown in Fig. 1(a). In Fig. 1(a), 12 is the spiral coil, and 12a and 12b are the terminals. Fig. 1(b) is a top view of the spiral coil formed on the flexible substrate. As the flexible substrate, for example, a polyimide flexible substrate can be used. The shape of the spiral coil is preferably symmetric between the upper half and the lower half in Fig. 1(a). Note that the number of winding turns in Fig. 1(a) and Fig. 1(b) is not limited to the illustrated number and can be increased several times. When the coil substrate is wound around a stent and used as a receiving coil, in order to prevent the induced magnetic fluxes from canceling each other out, split slits may be provided in the conductive line along the circumferential direction of the stent. The number of split slits is not particularly limited, but it is preferably 2 to 4 per turn in the circumferential direction of the stent. If the number is even, the magnetic fields are less likely to be in opposite directions and cancel each other out, so 2 or 4 is more preferable. One aspect of the spiral coil with split slits is shown in Figs. 2(a) and (b) respectively. In each figure, 21 is the stent, 22 is the conductive line constituting the spiral coil, and 22a is the split slit for splitting the conductive line. Fig. 2(a) is an example in which two split slits 22a per turn are provided in the conductive line 22, and Fig. 2(b) is an example in which three split slits 22a per turn are provided in the conductive line 22. Also, when the coil substrate is wound around the stent and used as a receiving coil, the coil substrate itself may be divided into two to form a pair of coil halves, and each may be wound around the outer peripheral surface of the stent so as not to overlap each other. Thereby, the cross-sectional area through which the magnetic flux passes can be widened.

[0042] FIG. 1(c) shows an example of a wound coil (solenoid coil). The wound coil can be formed by winding an electric wire around the stent to form a cylindrical wound body. The wound coil may be formed at only one location on the stent, or may be formed at two or more locations. In the present invention, as shown in FIG. 1(d), both a wound coil and a spiral coil may be formed on the surface of the stent. The wound coil and the spiral coil may be formed adjacent to each other, or may be formed at separated positions. Also, in the longitudinal direction of the stent, they may be formed in the order of wound coil, spiral coil, wound coil, or in the order of spiral coil, wound coil, spiral coil. Further, the wound coil and the spiral coil may be alternately formed a plurality of times. The directions in which the magnetic flux passes through the wound coil and the spiral coil are different by 90 degrees. Therefore, regardless of the direction in which the magnetic flux of the power transmission coil is directed, power reception can be ensured as long as the stent has both a wound coil and a spiral coil formed on its surface. When the wireless power feeding type light irradiation device of the present invention is implanted in the body, the power transmission coil can be installed on the bed or worn on the body as a belly band. At this time, even if the angle between the stent implanted in the body and the power transmission coil changes due to the movement of the body or the movement of the power transmission coil, as long as the stent has both a wound coil and a spiral coil formed on its surface, fluctuations in the received power can be suppressed and a stable light emission intensity can be maintained. The winding coil may be wound, for example, at an angle of 85 degrees or more and less than 90 degrees so that the electric wire is substantially orthogonal to the longitudinal direction of the stent, or may be wound at a larger angle, for example, 70 degrees or more and 85 degrees or less, for example, 60 degrees or more and 70 degrees or less, for example, 45 degrees or more and 60 degrees or less. The same applies to the spiral coil. As an example of such a winding method with an angle, a mode of winding in a ribbon shape as shown in Fig. 1(e) can be exemplified.

[0043] -Receiving Circuit- The receiving circuit has a function of converting the induced current from the receiving coil into electric power that can be utilized by the surface light-emitting element. The receiving circuit preferably includes at least an electronic component that forms a resonance circuit in combination with the receiving coil and a diode. Examples of the electronic component that forms a resonance circuit (LC resonance circuit) in combination with the receiving coil include a capacitor. The induced current from the receiving coil is amplified at a specific frequency in the resonance circuit and converted into a direct current by the diode. When this direct current is supplied to the surface light-emitting element, the surface light-emitting element emits light.

[0044] In addition, other circuits may be incorporated in the receiving circuit. For example, when the distance between the transmitting coil and the receiving coil fluctuates, the voltage applied to the surface light-emitting element may fluctuate and the brightness may change. In particular, when the distance becomes short, it is important to prevent the brightness from rising more than expected and the temperature of the surface light-emitting element from increasing. It is particularly preferable that the receiving circuit is provided with a current limiting circuit or a voltage limiting circuit (regulator) for preventing this. An example of the electronic circuit of the wireless power supply type light irradiation device of the present invention is shown in Fig. 3. In Fig. 3, 11 is a surface light-emitting element, 23 is a receiving circuit, 24 is a receiving coil, 25 is a capacitor, 26 is a resonance circuit, and 27 is a rectifying circuit. Here, the resonance circuit 26 is formed by the receiving coil 24 and the capacitor 25, the receiving circuit is formed by the capacitor 25 and the rectifying circuit 27, and the power receiving unit is formed by the receiving coil 24, the capacitor 25, and the rectifying circuit 27.

[0045] The receiving circuit is mounted, for example, on a flexible substrate. By winding a receiving circuit board with the receiving circuit mounted on the flexible substrate around the outer periphery of the stent and electrically connecting it to the receiving coil and the surface light-emitting element, the function of the receiving circuit can be obtained. Also, when a coil substrate is used for the receiving coil, the receiving circuit may be mounted on the flexible substrate of the coil substrate. That is, the conductive film pattern of the coil (for example, a spiral coil) and the receiving circuit (for example, a receiving circuit including a capacitor and a diode) may be mounted on the same flexible substrate. In this case, the conductive film pattern of the coil and the receiving circuit may be formed side by side on the same surface of the flexible substrate, or the conductive film pattern of the coil may be formed on one surface of the flexible substrate and the receiving circuit may be formed on the other surface. By winding a coil receiving circuit board with both the conductive film pattern of the coil and the receiving circuit mounted on the flexible substrate around the outer periphery of the stent and electrically connecting it to the surface light-emitting element, the function of the receiving circuit can be obtained. At this time, in the coil receiving circuit board in which the conductive film pattern of the coil is formed on one surface of the flexible substrate and the receiving circuit is formed on the other surface, it is preferable to wind it around the outer periphery of the stent so that the side on which the conductive film pattern of the coil is formed is on the outside.

[0046] The stent-shaped wireless power supply type light irradiation device of the present invention has a power receiving coil, a matching circuit, and a surface light-emitting element. These are assembled so as not to overlap each other with a two-dimensional spread, and it is preferable to finally complete it as a stent having a light-emitting function. It can also be stacked three-dimensionally on a cylindrical base material. In this case, the power receiving coil, the matching circuit, and the surface light-emitting device are arranged in this order from the inside, but the power receiving coil and the matching circuit may be formed on a single substrate. By providing the power receiving coil under the surface light-emitting device in this way, the light-emitting area of the stent can be maximized.

[0047] [Other parts] The wireless power supply type light irradiation device of the present invention may have components other than the stent, the planar light emitting element, and the power receiving unit, if necessary. Examples of such components include an illuminance sensor and a temperature sensor. The "illuminance sensor" detects the light emission amount of the planar light emitting element. By monitoring the light emission amount of the planar light emitting element using the illuminance sensor, it is possible to confirm that the element is operating normally, or to confirm the relationship between the light emission amount and the treatment effect and use it for treatment plan formulation. The "temperature sensor" detects the temperature of the wireless power supply type light irradiation device. By monitoring the temperature of the wireless power supply type light irradiation device using the temperature sensor and configuring it so that power supply is cut off when the device reaches a specific temperature or higher, it is possible to prevent the tissue around the device from being thermally damaged by the heat generated by the planar light emitting element or the coil. Here, there is a correlation between the temperature of the wireless power supply type light irradiation device and the drive voltage and drive current of the planar light emitting element, such that the drive voltage decreases as the device temperature increases, and the drive current increases as the device temperature increases. Therefore, the device temperature can be estimated by monitoring the drive voltage and drive current of the planar light emitting element, and the device may be configured such that the above-described power supply cut-off is performed when the drive voltage falls below the voltage value corresponding to a specific temperature, or when the drive current exceeds the current value corresponding to a specific temperature. These sensors can be constantly driven using the power of the wireless power supply of the present invention. That is, the received power is converted to direct current through a constant voltage circuit by a diode, and then connected to, for example, a Bluetooth R module on which the above sensor is mounted, so that data can be recorded by the external PC or smartphone. As a result, the device can constantly observe the temperature rise and the presence or absence of light emission around it while emitting light. Note that the frequencies for these Bluetooth R communications are different from the frequencies for wireless light emission of the present invention, and they do not interfere with each other.

[0048] [Sealing material] In the wireless power supply type light irradiation device of the present invention, each part formed on the outer periphery of the stent may be covered with a sealing material and fixed to the stent while being sealed. The sealing material is preferably a film that can transmit the light emitted by the surface light emitting element and has flexibility and biocompatibility. In the following description, the film of the sealing material having biocompatibility may be referred to as a "biocompatible film". As a preferable example of the sealing material, a parylene film mainly composed of parylene can be mentioned. Parylene is a p-xylene-based polymer obtained from p-xylene and has excellent biocompatibility. In parylene, the hydrogen atoms of the structural units derived from p-xylene may be substituted with substituents such as halogen atoms. The parylene film preferably contains 70% by weight or more of parylene, and is also preferably composed only of parylene.

[0049] Also, a known sealing adhesive may be used as the sealing material. For example, various commercially available products such as a UV (Ultraviolet) curable epoxy resin (TB3124M manufactured by Three Bond Co., Ltd.) with high water and oxygen barrier properties and (trade name Moisture Cut) manufactured by Moresco Co., Ltd. can be used. Also, a sealing film mixed with a moisture-proof agent manufactured by Ajinomoto Fine-Techno Co., Inc. can also be preferably used. In order to prevent the light emitting element from deteriorating due to moisture, it is preferable to cover the upper part of the light emitting element 2 with OleDry-F (Ore Dry F) manufactured by Futaba Electronic Industries Co., Ltd. or to apply DryFlex manufactured by SAES Getters S.p.A.

[0050] The thickness of the sealing material is not particularly limited, but can be selected, for example, from the range of 0.1 to 10 μm.

[0051] [Arrangement of surface light emitting element and power receiving part] The arrangement of the surface light emitting element and the power receiving part formed on the surface of the stent is not particularly limited. Preferred embodiments of the arrangement of each part are shown in FIGS. 4 to 6. The wireless power supply type light irradiation device 3 shown in Fig. 4 has a receiving coil 32, a receiving circuit board 33, and a planar light emitting element 11 arranged side by side along the longitudinal direction of the stent 10, and is configured to be sealed by a biocompatible film (sealing material) 35 that entirely covers these respective parts 11, 32, 33. The circuit of the receiving coil 32 and the receiving circuit board 33, and the circuit of the receiving circuit board 33 and the electrodes of the planar light emitting element 11 are electrically connected by conducting wires respectively. Here, the receiving coil 32 and the receiving circuit board 33 constitute a power receiving unit 36. The receiving coil 32 may be a wound coil, or may be a cylindrical body formed by winding a coil substrate around the stent. Also, the power receiving unit 36 may be constituted by a coil receiving circuit board on which a conductive film pattern of the receiving coil and a receiving circuit are mounted. In a preferred embodiment of the present invention, the receiving coil 32 is a wound coil, and the planar light emitting element 11 is an organic electroluminescence element. In this wireless power supply type light irradiation device, an induced current is generated in the receiving coil 32 due to a change in the magnetic flux applied from an external power transmitter, and this induced current resonates and is rectified at a specific frequency in the power receiving unit and supplied to the planar light emitting element 11. Due to this power, the planar light emitting element 11 emits light.

[0052] The wireless power supply type light irradiation device 4 shown in Fig. 5 has a coil receiving circuit board (power receiving unit) 42 and a planar light emitting element 11 arranged side by side along the longitudinal direction of the stent 10, and is configured to be sealed by a biocompatible film (sealing material) 44 that entirely covers these respective parts 42, 43. On the flexible substrate of the coil receiving circuit board 42, a first coil 42a and a second coil 42b, which are conductive film patterns, are arranged with a space therebetween, and a receiving circuit 42c is mounted on this space. That is, on the coil receiving circuit board 42, the first coil 42a, the receiving circuit 42c, and the second coil 42b are arranged side by side along the longitudinal direction of the stent 10. And the first coil 42a and the second coil 42b are electrically connected to the receiving circuit 42c by wiring, and the receiving circuit 42c and the planar light emitting element 11 are electrically connected by a conducting wire.

[0053] The wireless power supply type light irradiation device 5 shown in Fig. 6 has a first coil 52, a first receiving circuit board 53, a planar light emitting element 11, a second receiving circuit board 55, and a second coil 56 arranged in this order along the longitudinal direction of the stent 10, and is configured to be sealed by a biocompatible film (not shown) that entirely covers these respective parts 52, 53, 54, 55, 56. The circuit of the first receiving coil 52 and the first receiving circuit board 53, the circuit of the second receiving coil 56 and the second receiving circuit board 55, and the electrodes of the planar light emitting element 11 and the circuits of the first and second receiving circuit boards 53, 55 are electrically connected by conducting wires respectively. Here, the first receiving coil 52 and the first receiving circuit board 53 constitute a first power receiving unit 57, and the second receiving coil 56 and the second receiving circuit board 55 constitute a second power receiving unit 58. The first receiving coil 52 and the second receiving coil 56 may be wound coils, or may be cylindrical bodies formed by winding a coil substrate around the stent. Also, one of the first receiving coil 52 and the second receiving coil 56 may be a wound coil (solenoid coil) and the other may be a coil substrate (spiral coil). Further, a coil receiving circuit board on which a spiral coil and a receiving circuit are mounted may constitute one or both of the first power receiving unit 57 and the second power receiving unit 58. Regarding the operation of the wireless power supply type light irradiation device shown in Figs. 5 and 6, reference can be made to the description of the operation of the wireless power supply type light irradiation device shown in Fig. 4.

[0054] <The second aspect> The wireless power supply type light irradiation device of the second aspect has a stent, a planar light emitting element, and a power receiving unit electrically connected to the planar light emitting element. The planar light emitting element is formed on the surface of the stent, but the power receiving unit is installed at a position different from the stent. The planar light emitting element and the power receiving unit are electrically connected via, for example, a conducting wire. The position where the power receiving unit is installed is, for example, outside the living body to which the wireless power supply type light irradiation device is applied. In this case, the power receiving unit may be worn on the living body or installed at a location away from the living body. In the second aspect, for the description of the stent and the planar light-emitting element, reference can be made to the corresponding description in the column of "the first aspect". The power receiving unit has at least a receiving coil and a receiving circuit. The receiving coil may be a wound coil or a conductive film pattern of a coil formed on a coil substrate. The receiving circuit is mounted on a substrate to constitute a receiving circuit board. Further, a coil receiving circuit board on which both the conductive film pattern of the coil and the receiving circuit are mounted may be used as the power receiving unit. For the description of the wound coil, the coil substrate, the receiving circuit board, and the coil receiving circuit board, reference can be made to the corresponding description in the column of "the first aspect". However, the substrate used for the coil substrate, the receiving circuit board, and the coil receiving circuit board may be a flexible substrate or a rigid substrate. As the rigid substrate, a known rigid substrate usually used for a circuit board can be appropriately selected and used. In the wireless power supply type light irradiation device of the second aspect, an induced current is generated in the receiving coil due to a change in the magnetic flux applied from an external power transmitter, and this induced current resonates and is rectified at a specific frequency in the power receiving unit and is supplied to the planar light-emitting element via a conducting wire. By this power, the planar light-emitting element emits light.

[0055] <Method for manufacturing a wireless power supply type light irradiation device> The wireless power supply type light irradiation device of the present invention can be manufactured by combining known manufacturing methods of a planar light-emitting element such as an organic electroluminescence element, a wound coil, a coil substrate, and a circuit board. For example, when forming the planar light-emitting element, the organic layer of the light-emitting element can be formed by coating or vapor deposition. Also, the metal layer and other inorganic layers such as electrodes included in the planar light-emitting element can be formed by coating or vapor deposition. Specifically, the planar light-emitting element can be manufactured using known methods such as vacuum vapor deposition method, sputtering method, inkjet method, screen printing method, flexographic printing method, spin coating, etc. The formation of the conductive films and the encapsulant of the coil substrate, the receiving circuit substrate, and the coil receiving circuit substrate can also be performed using coating or vapor deposition. The patterning of the conductive film can be performed using known microfabrication techniques such as photolithography, and the mounting of electronic components can also be performed using known mounting techniques.

[0056] <Light irradiation device> The light irradiation device of the present invention includes the wireless power supply type light irradiation device and the power transmitter of the present invention. For the description of the wireless power supply type light irradiation device, reference can be made to the description in the above section of "Wireless power supply type light irradiation device". By using the wireless power supply type light irradiation device and the power transmitter in combination, when the wireless power supply type light irradiation device is implanted in the living body, power can be supplied from the power transmitter to the wireless power supply type light irradiation device.

[0057] [Power transmitter] The power transmitter is not particularly limited as long as it can wirelessly supply power to the wireless power supply type light irradiation device. The power transmitter preferably has a transmission antenna. As the transmission antenna, a transmission coil is preferred. It is preferable that the power transmitter has a transmission coil and a high-frequency power source. The frequency can be used in the range from several kHz to several GHz. For example, it may be selected within the range of 10 kHz to 100 MHz. These vary depending on the application. By combining the transmission coil and the reception coil, power can be efficiently wirelessly supplied from the transmission coil to the reception coil by known magnetic field coupling methods or electric field coupling methods. However, the power transmitter is not limited to the mode having a coil as long as it can supply power to the wireless power supply type light irradiation device.

[0058] (Transmission coil) The transmission coil preferably has a diameter set according to the distance for wireless power supply to the wireless power supply type light irradiation device. When using a cylindrical winding coil as the transmission coil, the diameter of the winding coil is, for example, 0.1 to 0.5 mm, preferably 0.15 to 0.3 mm. It is preferable to use a copper wire as the cylindrical winding coil. The copper wire may be plated with tin or silver. The diameter of the wireless light irradiation device also varies depending on the tubular organ to be applied. For example, for bile duct cancer, there are a plastic stent with a diameter of 2 to 3 mm, and a metal stent that expands to about 8 to 10 mm by advancing through the channel of an endoscope in a state of being contained in a sheath with a diameter of 2 to 3 mm and then removing the outer sheath. For a stent for the large intestine, there are also those with a diameter exceeding 20 mm. The wireless power supply type light irradiation device of the present invention can be properly selected depending on the site of the disease to be applied. Also, it is preferable to form the coil and the light emitting element on a plastic base material rather than a metal base material having a property of spreading in the body. If the diameter of the transmission coil is within the above range, for example, by fixing the power transmitter at a position close to the patient or attaching it to the patient's body with a belt or the like, sufficient power (for example, 50 W or less) can be supplied to the wireless power supply type light irradiation device. There is no particular limitation on the material of the transmission coil, but it is preferable that the resistance is low. Known materials can be used, for example, low-resistance metals such as copper, silver, and alloys containing at least one of copper and silver can be used. In addition to the cylindrical winding coil, a square, mesh-shaped, or comb-shaped coil may be used for the transmission coil, and there is no limitation on the shape for converting high-frequency energy into electromagnetic waves.

[0059] The power transmitter may have other circuits other than the transmission coil. The power transmitter may have a capacitor for the purpose of resonating the transmission coil or the like.

[0060] (High-frequency power supply) There is no particular limitation on the high-frequency power supply, and known ones can be used. The high-frequency power supply may be connected to an external power supply (preferably alternating current).

[0061] [Relay coil] The light irradiation device of the present invention may have a relay coil if necessary. Here, the "relay coil" means a coil disposed between the transmission coil of the power transmitter and the reception coil of the wireless power feeding type light irradiation device. By using the relay coil, the magnetic field of the transmission coil and the magnetic field induced by the relay coil are coupled to expand the magnetic field region, and the wireless power transmission distance can be extended. In particular, in the living body, the wireless power transmission distance is smaller than that in the atmosphere. Therefore, by using the relay coil, the power feeding efficiency can be effectively improved, and the irradiation intensity of the wireless power feeding type light irradiation device can be improved. The relay coil is preferably attached to, for example, the skin, clothes, bed, etc. close to the tumor site of the patient.

[0062] [Electronic circuit of the light irradiation device] An example of the electronic circuit used in the light irradiation device of the present invention is shown in FIG. 8. In FIG. 8, 201 is a wireless power feeding type light irradiation device, 202 is a power receiving unit, 24 is a reception coil as a reception antenna, 11 is a surface light emitting element, 205 is a power transmitter, 206 is a transmission coil as a transmission antenna, 207 is a high-frequency power source, and 208 is an external AC power source. Other electronic components (capacitors, rectifier circuits, etc.) of the light irradiation device are not shown. The reception coil 24 and the transmission coil 206 may be winding coils or coil substrates. In the light irradiation device having such an electronic circuit, the magnetic flux generated by the transmission coil 206 is applied to the reception coil 203, and an induced current is generated in the reception coil 203 due to the change in the magnetic flux. This induced current resonates and is rectified at a specific frequency in the power receiving unit 202 and supplied to the surface light emitting element 11. By this power, the surface light emitting element 11 emits light. Here, the power supplied to the wireless power supply type light irradiation device increases as the diameter of the transmission coil increases and also increases as the distance L between the transmission coil and the reception coil decreases. Therefore, it is preferable to select the diameter of the transmission coil according to the installation position of the power transmitter. For example, when the power transmitter is worn on the patient's body with a belt or the like, the preferable range of the diameter of the transmission coil is as shown in the column of the above "transmission coil".

[0063] <Light irradiation method> The light irradiation method of the present invention is a light irradiation method in which power is supplied from the power transmitter of the light irradiation device of the present invention to the power receiving unit of the wireless power supply type light irradiation device, and the power receiving unit supplies power to the electrodes of the light emitting element to cause the light emitting element to emit light. In the light irradiation method of the present invention, it is preferable to implant the wireless power supply type light irradiation device into the living body by a known stent placement technique or surgery, and it is more preferable to implant it into a lumen such as a bile duct or a trachea. In the light irradiation method of the present invention, it is preferable to supply power with a distance of 5 to 1000 mm between the reception coil of the wireless power supply type light irradiation device and the transmission coil of the power transmitter, more preferably with a distance of 10 to 500 mm between the transmission coil and the reception coil, and particularly preferably with a distance of 10 to 300 mm between them. In the light irradiation method of the present invention, the installation position of the power transmitter is not particularly limited. For example, the power transmitter may be fixed at a position close to the patient, or may be worn on the patient's body with a belt or the like. The power supplied from the power transmitter to the power receiving unit of the wireless power supply type light irradiation device is preferably 50 W or less for easy use according to the radio wave law, and preferably 20 W or less in order to reduce heat generation of the high-frequency amplifier, but is not limited thereto.

[0064] (Photosensitive substance) The photosensitive substance used in the present invention can be selected from known photosensitive substances. The mechanism of photodynamic therapy is as follows: First, the photosensitive substance is accumulated in advance in the target tumor by taking or intravenous injection, etc., and then the tumor part is irradiated with light to absorb the light and enter an excited state. Next, the excited photosensitive substance transfers energy to singlet oxygen in the cell to generate active oxygen including triplet oxygen. Furthermore, these active oxygen attack and kill tumor cells. Therefore, the photosensitive substance used in the present invention is a substance that absorbs the irradiated light, and any type of substance can be used as long as it can transfer energy to oxygen in the cell. So far, porphyrin derivatives such as Photofrin, Razafurin, Protoporphyrin, Temoporfin, or aminolevulinic acid derivatives which are their precursors, and dyes such as methylene blue have been used, but quantum dots as described in Nature Communication, 2014 DOI: 10.1038 / ncomms5596 can also be used.

[0065] (Treatment) Diseases that can be treated by a light irradiation device include internal diseases and the like. For example, diseases in the malignant pre-stage and malignant diseases can be mentioned. Examples of treatable diseases include, in addition to primary and metastatic tumors, inflammatory diseases such as connective tissue diseases, all types of arthritis, and inflammatory bowel diseases. It is particularly effective for visceral cancers (such as liver cancer, pancreatic cancer, ovarian cancer, etc.). The mechanism by which the above diseases can be treated by phototherapy is known (see, for example, CANCER June 15, 1997 / Volume 79 / Number 12, p2282). These diseases can be treated with the light irradiated from the wireless power supply type light irradiation device used in the present invention. In photodynamic therapy (PDT), a known photosensitive therapeutic agent as a photochemotherapeutic agent is applied topically or internally to the area of the body to be treated, and the area is exposed to light of an appropriate frequency and intensity to activate the photochemotherapeutic agent. Currently, various photochemotherapeutic agents are available (see, for example,

[0002] of Patent No. 4651281). In photoimmunotherapy, for example, an antibody drug conjugated with a substance having near-infrared light absorption ability is conjugated to a protein that adheres to cancer cells, and the cancer cells are irradiated with near-infrared light using a wireless power supply type light irradiation device. This induces apoptosis in the cancer cells to treat cancer. FIG. 7 shows a treatment example in which the wireless power supply type light irradiation device of the present invention is applied to the bile duct. The wireless power supply type light irradiation device 101 of the present invention is inserted into the bile duct where stenosis has occurred due to a tumor 102 formed around the bile duct. A normal stent has a function of expanding the diameter by inserting it into the bile duct so that bile can flow sufficiently, but it does not have a treatment function. On the other hand, when the wireless power supply type light irradiation device of the present invention is inserted into the bile duct, the stored bile 103 is discharged into the intestine in the direction of the arrow, and treatment can be performed by the planar light emitting element formed on the surface of the stent emitting light. Since the tumor is formed around the bile duct, effective treatment cannot be performed unless the entire area around the bile duct is uniformly irradiated with light. Since the wireless power supply type light irradiation device of the present invention has a planar light emitting element formed on the surface of the stent, uniform light irradiation over the entire area around the bile duct can be realized, and cancer can be effectively treated.

Explanation of Reference Numerals

[0066] 3, 4, 5, 101, 201 Wireless power supply type light irradiation device 10 Stent 11 Planar light emitting element 12 Spiral coil 12a, 12b Terminals 22 Conductive line constituting the spiral coil 22a Split slit 23 Receiving circuit 24, 32, 203 Receiving coil 25 Capacitor 26 Resonance circuit 27 Rectifying circuit 33 Receiving circuit board 35, 44 Biocompatible membrane (sealing material) 36, 202 Power receiving unit 42 Coil receiving circuit board 42a First coil 42b Second coil 42c Receiving circuit 52 First coil 53 First receiving circuit board 55 Second receiving circuit board 56 Second coil 57 First power receiving part 58 Second power receiving part 102 Tumor 103 Accumulated bile 205 Power transmitter 206 Transmitting coil 207 High-frequency power source 208 External AC power source

Claims

1. A wireless power supply type light irradiation device, which has a stent, a planar light emitting element formed on the surface of the stent, and a power receiving unit electrically connected to the planar light emitting element, and is used for irradiating a part of the living body from inside the living body.

2. The wireless power supply type light irradiation device according to Claim 1, wherein the planar light emitting element is formed on a flexible substrate.

3. The wireless power supply type light irradiation device according to Claim 1, wherein the planar light emitting element is an organic electroluminescence element.

4. The wireless power supply type light irradiation device according to Claim 1, wherein at least a part of the planar light emitting element covers 25% or more of the outer circumference of the stent.

5. The wireless power supply type light irradiation device according to Claim 1, wherein the planar light emitting element is formed over a length of 2 mm or more in the longitudinal direction of the stent.

6. The wireless power supply type light irradiation device according to Claim 1, wherein the power receiving unit has a receiving coil and a receiving circuit.

7. The wireless power supply type light irradiation device according to Claim 6, wherein the receiving coil is formed on the surface of the stent.

8. The wireless power supply type light irradiation device according to Claim 7, wherein a winding coil is formed on the surface of the stent as the receiving coil.

9. The wireless power supply type light irradiation device according to Claim 7, wherein a spiral coil is formed on the surface of the stent as the receiving coil.

10. The wireless power supply type light irradiation device according to Claim 7, wherein a winding coil and a spiral coil are formed on the surface of the stent as the receiving coil.

11. The wireless power supply type light irradiation device according to Claim 1, wherein the stent is formed of plastic.

12. The wireless power supply type light irradiation device according to Claim 1, which has an illuminance sensor.

13. The wireless power supply type light irradiation device according to Claim 1, which has a temperature sensor.

14. The wireless power supply type light irradiation device according to Claim 1, wherein the light emission of the planar light emitting element reaches over 360 degrees of the outer circumference of the stent.

15. A light irradiation device, which includes the wireless power supply type light irradiation device according to any one of Claims 1 to 14 and a power transmitter.

16. A light irradiation method for supplying power from the power transmitter of the light irradiation device according to claim 15 to the power receiving unit of the wireless power supply type light irradiation device, and causing the power receiving unit to supply power to the planar light emitting element to emit light from the planar light emitting element.

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