Sample analyzer
The sample analyzer addresses inefficiencies in reagent loading by using a transfer mechanism to enable simultaneous reagent loading across multiple storage mechanisms, ensuring continuous operation and reduced temperature exposure.
Patent Information
- Application Number
- JP2025011584
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-01-26
- Filing Date
- 2025-01-27
- Publication Date
- 2025-08-07
- Estimated Expiration
- 2045-01-27
AI Technical Summary
Existing sample analyzers face inefficiencies due to the need for manual reagent addition, which disrupts testing and requires operators to wait for reagent availability, necessitating a solution for continuous reagent loading without stopping.
A sample analyzer design incorporating a reagent container storage mechanism with a reagent container transfer mechanism that allows simultaneous loading of reagents across multiple storage mechanisms within a limited space, utilizing a center line connection and temporary storage mechanisms to facilitate uninterrupted reagent supply.
Enables continuous and efficient reagent loading without stopping, optimizing reagent supply and reducing exposure time to external temperatures, thereby enhancing testing efficiency.
Smart Images

Figure 2025115985000001_ABST
Abstract
Description
[Technical Field]
[0001] The present invention relates to the technical field of analytical instruments, and in particular to sample analyzers. [Background technology]
[0002] Biochemical analyzers, immunoanalyzers, and cell analyzers all belong to the category of sample analyzers, and are instruments used to perform qualitative and quantitative analysis on samples.
[0003] In the process of continuously testing and analyzing samples, if a sample analyzer requires manual addition of reagents, not only will it affect the testing efficiency of the analyzer, but the operator will also have to wait for the analyzer to enter a state where reagents can be manually added. Therefore, how to load reagents in real time without stopping based on the amount of available reagent remaining in the reagent container storage mechanism and ensure an effective supply of reagents has become an urgent issue that must be resolved in order for sample analyzers to efficiently test samples. Summary of the Invention [Problem to be solved by the invention]
[0004] The main object of the present application is to provide a sample analyzer that can install two reagent container storage mechanisms within a limited space and that can simultaneously load reagent containers continuously without the two reagent container storage mechanisms stopping. [Means for solving the problem]
[0005] A sample analyzer according to an aspect of the present invention comprises: a reaction disk provided on the stage; a first reagent container storage mechanism; a second reagent container storage mechanism; a reagent container temporary storage mechanism for placing a reagent container thereon and positioned between the first reagent container storage mechanism and the second reagent container storage mechanism; a reagent container transfer mechanism; a first rotation center of the first reagent container storage mechanism and a second rotation center of the second reagent container storage mechanism are connected to form a center line; a third rotation center of the reagent container temporary storage mechanism and a fourth rotation center of the reaction disk are located on both sides of the center line, respectively; The reagent container transfer mechanism is used to transfer reagent containers between the first reagent container storage mechanism and the reagent container temporary storage mechanism, and / or between the second reagent container storage mechanism and the reagent container temporary storage mechanism.
[0006] Furthermore, the transfer path of the reagent container transfer mechanism is parallel to the center line, and the number of the first loading / unloading position of the first reagent container storage mechanism, the second loading / unloading position of the second reagent container storage mechanism, and the third loading / unloading position of the reagent container storage mechanism is at least one each.
[0007] Furthermore, the first reagent container storage mechanism includes a first storage inner plate and the first storage outer plate, and the first storage inner plate is located inside the first storage outer plate; the first inner storage cabinet has a first inner loading / unloading position corresponding to the transfer path, and the first outer storage cabinet has a first outer loading / unloading position corresponding to the transfer path; the second reagent container storage mechanism includes a second inner storage plate and a second outer storage plate, the second inner storage plate is located inside the second outer storage plate, the second inner storage plate has a second inner access position corresponding to the transfer path, and the second outer storage plate has a second outer access position corresponding to the transfer path; the reagent container temporary storage mechanism includes a temporary storage inner plate and a temporary storage outer plate, the temporary storage inner plate is located inside the temporary storage outer plate, the temporary storage inner plate has a third inner access position corresponding to the transfer path, and the temporary storage outer plate has a third outer access position corresponding to the transfer path; The reagent container transfer mechanism is used to transfer reagent containers between the first inner access position or the first outer access position and the third inner access position or the third outer access position, and / or is used to transfer reagent containers between the second inner access position or the second outer access position and the third inner access position or the third outer access position.
[0008] Furthermore, a line connecting the first inner insertion / removal position and the first rotation center and a line connecting the first outer insertion / removal position and the first rotation center form a first angle, a line connecting the second inner insertion / removal position and the second pivot center and a line connecting the second outer insertion / removal position and the second pivot center form a second angle; A line connecting the third inner insertion / removal position and the third pivot center and a line connecting the third outer insertion / removal position and the third pivot center form a third angle.
[0009] Furthermore, the first storage inner plate is configured to form a plurality of first internal mounting positions for supporting reagent containers along a circumferential direction of the first rotation center, and the first storage inner plate rotates so that the plurality of first internal mounting positions sequentially pass through the first internal loading / unloading position; the first outer storage base is configured to form a plurality of first outer mounting positions for supporting reagent containers along a circumferential direction of the first rotation center, and the first outer storage base rotates so that the plurality of first outer mounting positions sequentially pass through the first outer loading / unloading position; the second storage inner platen is formed with a plurality of second internal mounting positions for supporting reagent containers along a circumferential direction of the second rotation center, and the second storage inner platen rotates so that the plurality of second internal mounting positions sequentially pass through the second internal loading / unloading position; the second outer storage base is configured to form a plurality of second outer mounting positions for supporting a plurality of reagent containers along a circumferential direction of the second rotation center, and the second outer storage base rotates so that the second outer mounting positions sequentially pass through the second outer loading / unloading position; the temporary storage inner plate is configured to form a plurality of third internal mounting positions for supporting reagent containers along a circumferential direction of the third rotation center, and the temporary storage inner plate rotates so that the plurality of third internal mounting positions sequentially pass through the third internal loading / unloading position; the temporary storage outer plate is configured to form a plurality of third outer mounting positions for supporting reagent containers along a circumferential direction of the third rotation center, and the temporary storage outer plate rotates such that the plurality of third outer mounting positions sequentially pass through the third outer loading / unloading position; The reagent container transfer mechanism is used to transfer a reagent container between the first inner access position or the first outer access position and the third inner access position, or to transfer a reagent container between the first inner access position or the first outer access position and the third outer access position, or to transfer a reagent container between the second inner access position or the second outer access position and the third inner access position, or to transfer a reagent container between the second inner access position or the second outer access position and the third outer access position.
[0010] Furthermore, the third loading / unloading position includes a third left loading / unloading position close to the first reagent container storage mechanism and a third right loading / unloading position close to the second reagent container storage mechanism, and the reagent container transfer mechanism transfers reagent containers between the first loading / unloading position and the third left loading / unloading position, and between the second loading / unloading position and the third right loading / unloading position.
[0011] Furthermore, a vertical symmetry line is formed that passes through the fourth pivot center and is perpendicular to the center line, and the third pivot center is offset from the vertical symmetry line and is close to the first reagent container storage mechanism or the second reagent container storage mechanism.
[0012] Furthermore, the vertical symmetry line and the vertical foot of the center line are located at the midpoint of the center line.
[0013] Furthermore, the reagent container transfer mechanism a loading / unloading device for loading / unloading reagent containers; a rotation drive device for driving the rotation of the take-in / take-out device; an elevation drive device for driving the loading / unloading device to elevate and lower; a horizontal drive device; The horizontal drive device drives the loading / unloading device to move along the transfer path between the first loading / unloading position and the third loading / unloading position, and between the second loading / unloading position and the third loading / unloading position.
[0014] Furthermore, the loading and unloading device may be a clip, or the loading and unloading device may be a suction nozzle, and the suction nozzle may be provided away from the rotation axis of the rotation drive device.
[0015] Furthermore, the first reagent container storage mechanism is configured to form a plurality of first placement positions for holding reagent containers along a circumferential direction of the first rotation center, and the first reagent container storage mechanism rotates so that the plurality of first placement positions sequentially pass through the first loading / unloading position; the second reagent container storage mechanism is configured to form a plurality of second placement positions for holding reagent containers along a circumferential direction of the second rotation center, and the second reagent container storage mechanism rotates such that the plurality of second placement positions sequentially pass through the second loading / unloading position; the reagent container temporary storage mechanism is configured to form a plurality of third placement positions for holding reagent containers along a circumferential direction of the third rotation center, and the reagent container temporary storage mechanism rotates such that the plurality of third placement positions sequentially pass through the third loading / unloading position; The reagent container transfer mechanism is used to transfer reagent containers between a first access position and the third access position or between the second access position and the third access position.
[0016] Furthermore, a horizontal symmetry line passing through the fourth rotation center and parallel to the center line is formed, The sample analyzer further includes a sample transport mechanism for transporting sample containers; The centerline and the specimen transport mechanism are located on opposite sides of the horizontal line of symmetry.
[0017] Furthermore, a collection box is further provided, and a collection port of the collection box is provided below the transfer path.
[0018] Furthermore, the recovery port is located between the first reagent container storage mechanism and the temporary reagent container storage mechanism, or the recovery port is located between the second reagent container storage mechanism and the temporary reagent container storage mechanism.
[0019] Furthermore, the reaction disk can support a plurality of reaction vessels and includes a first reagent-dispensing position, a second reagent-dispensing position, a third reagent-dispensing position, and a fourth reagent-dispensing position; the first reagent container storage mechanism includes a first reagent aspirating position and a second reagent aspirating position; the second reagent container storage mechanism includes a third reagent aspirating position and a fourth reagent aspirating position; the sample analyzer further includes a first reagent injection mechanism and a second reagent injection mechanism; the first reagent injection mechanism includes a first reagent needle and a second reagent needle that operate independently; the first reagent needle is used to aspirate a reagent from a reagent container located at the first reagent aspirating position, and transfer and inject the reagent along a first straight line into a reaction container located at the first reagent discharging position; the second reagent needle is used to aspirate a reagent from within a reagent container located at the second reagent aspirating position, and transfer and inject the reagent along a second straight line into a reaction container located at the second reagent discharging position; the second reagent injection mechanism includes a third reagent needle and a fourth reagent needle that operate independently; the third reagent needle is used to aspirate a reagent from within the reagent container at the third reagent aspirating position, and transfer and inject the reagent along a third straight line into a reaction container at the third reagent discharging position; The fourth reagent needle is used to aspirate reagent from a reagent container located at the fourth reagent aspirating position, and transfer and inject it along a fourth straight line into a reaction container located at the fourth reagent discharging position. [Effects of the Invention]
[0020] In the present application, the first rotation center and the second rotation center are connected to form the above-mentioned center line, the reagent container temporary storage mechanism and the reaction disk are provided on both sides of the center line, and the reagent container transfer mechanism is arranged to transfer reagent containers between the first reagent container storage mechanism and the temporary reagent container storage mechanism and / or between the second reagent container storage mechanism and the temporary reagent container storage mechanism. This makes it possible to install multiple mechanisms such as the temporary reagent container storage mechanism, the reaction disk, the first reagent container storage mechanism and the second reagent container storage mechanism in a limited space, and to simultaneously achieve uninterrupted loading of reagent containers by two reagent container storage mechanisms in the limited space. [Brief explanation of the drawings]
[0021] The drawings described herein are intended to provide a further understanding of the present application, which forms a part of the present application. The illustrative embodiments and the description thereof are intended to serve as an interpretation of the present application and are not to be construed as an undue limitation on the present application. In the drawings, [Figure 1] 1 is an overall schematic diagram of a sample analyzer according to one embodiment of the present disclosure; [Figure 2] 1 is an overall schematic diagram of a sample analyzer according to another embodiment of the present invention; [Figure 3] 1 is a schematic diagram of a reagent container loading module according to one embodiment of the present disclosure. [Figure 4] 2 is a schematic diagram of a partial structure of a first reagent injection mechanism in one embodiment disclosed in the present application. FIG. DETAILED DESCRIPTION OF THE INVENTION
[0022] In addition, the embodiments and features of the embodiments of the present application may be combined with each other if they do not conflict with each other. The present application will be described in detail below in accordance with the embodiments with reference to the drawings.
[0023] It should be noted that the terms used herein are not intended to limit the exemplary embodiments of the present application, but are used only to describe particular embodiments. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms unless the context clearly dictates otherwise. It should also be understood that the use of the terms "comprises" and / or "comprising" herein indicates the presence of features, steps, operations, devices, components, and / or combinations thereof.
[0024] The relative arrangement of components and steps, numerical formulas, and numerical values described in these embodiments do not limit the scope of the present invention unless otherwise specified. It goes without saying that the dimensions of each part shown in the drawings are not drawn to actual proportions for convenience of explanation. Techniques, methods, and devices known to those of ordinary skill in the art may not be discussed in detail; however, where appropriate, the techniques, methods, and devices should be considered part of the licensed specification. In all examples shown and discussed herein, specific numerical values should be considered illustrative and not limiting. Therefore, other examples of the illustrative embodiments may have different values. Similar symbols and letters represent similar items in the following drawings, so once a term is defined in one figure, there is no need to further discuss it in subsequent figures.
[0025] As shown in Figures 1 to 3, the sample analyzer 100 of the present invention includes a reaction disk 20 provided on a stage 10, and a first reagent container storage mechanism 31 and a second reagent container storage mechanism 32 provided outside the reaction disk 20.
[0026] The first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 each carry a reagent container 40. The reagent container 40 contains a reagent for performing detection suited to the specimen.
[0027] The first reagent container storage mechanism 31 is used to hold a plurality of types of reagent containers, and the second reagent container storage mechanism 32 is also used to hold a plurality of types of reagent containers.
[0028] Furthermore, the reagent in the reagent container held by the first reagent container storage mechanism 31 and the reagent in the reagent container held by the second reagent container storage mechanism 32 may be the same or different.
[0029] The sample analyzer 100 further includes a reagent container temporary storage mechanism 51. The reagent container temporary storage mechanism 51 is for carrying the reagent container 40, and is located between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32.
[0030] The sample analyzer 100 further includes a reagent container transfer mechanism 52. The reagent container transfer mechanism 52 transfers reagent containers 40 between the first reagent container storage mechanism 31 and the reagent container storage mechanism 51 and / or between the second reagent container storage mechanism 32 and the reagent container storage mechanism 51, thereby enabling uninterrupted loading of reagents by the first reagent container storage mechanism 31 and / or the second reagent container storage mechanism 32.
[0031] Furthermore, a center line 200 is formed between the first rotation center 315 of the first reagent container storage mechanism 31 and the second rotation center 325 of the second reagent container storage mechanism 32 so as to connect them.
[0032] The third rotation center 515 of the reagent container temporary storage mechanism 51 and the fourth rotation center 21 of the reaction disk 20 are located on both sides of the center line 200, respectively.
[0033] Since the reaction disk 20 needs to rotate to perform different detection operations at different operating positions, both the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 need to rotate to facilitate reagent collection.
[0034] Therefore, after the reaction disk 20, the first reagent container storage mechanism 31, and the second reagent container storage mechanism 32 are respectively mounted on the stage 10, the available space between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 is limited, and the reagent container storage mechanism 51 cannot be mounted on the aforementioned center line 200 based on the third rotation center 515.
[0035] Therefore, the present application arranges the reagent container transfer mechanism 52 to transfer the reagent container 40 between the first reagent container storage mechanism 31 and the reagent container storage mechanism 51, and / or between the second reagent container storage mechanism 32 and the reagent container storage mechanism 51, thereby enabling the reagent containers 40 to be loaded simultaneously by the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 without stopping within a limited space.
[0036] 2, in the first embodiment, the first reagent container storage mechanism 31 has a single-ring structure and has a first loading / unloading position 314 corresponding to the transfer path 300 of the reagent container transfer mechanism 52. The first reagent container storage mechanism 31 rotates around a first rotation center 315, thereby allowing the reagent container 40 held therein to pass through the first loading / unloading position 314.
[0037] The second reagent container storage mechanism 32 has a single ring structure and has a second loading / unloading position 324 corresponding to the transfer path 300. The second reagent container storage mechanism 32 rotates around a second rotation center 325, thereby allowing the reagent container 40 held therein to pass through the second loading / unloading position 324.
[0038] The reagent container temporary storage mechanism 51 has a single ring structure and has a third loading / unloading position 514 corresponding to the transfer path 300. The reagent container temporary storage mechanism 51 rotates around a third rotation center 515, allowing the reagent container 40 held therein to pass through the third loading / unloading position 514.
[0039] The first loading / unloading position 314, the second loading / unloading position 324 and the third loading / unloading position 514 are each located below the transfer path 300 so that the reagent container transfer mechanism 52 can transfer reagent containers 40 between the first loading / unloading position 314 and the third loading / unloading position 514 and / or between the second loading / unloading position 324 and the third loading / unloading position 514.
[0040] Furthermore, for the first reagent container storage mechanism 31 having a single ring structure, the first junction where the transfer path 300 and the first reagent container storage mechanism 31 meet is the above-mentioned first loading / unloading position 314. Alternatively, each of the two first intersections where the transfer path 300 and the first reagent container storage mechanism 31 intersect is the above-mentioned first loading / unloading position 314. That is, the first loading / unloading position 314 includes a first left loading / unloading position which is the first intersection along the transfer path 300 away from the second reagent container storage mechanism 32, and a first right loading / unloading position which is the first intersection along the transfer path 300 close to the second reagent container storage mechanism 32.
[0041] For the second reagent container storage mechanism 32 having a single ring structure, the second junction where the transfer path 300 and the second reagent container storage mechanism 32 meet is the above-mentioned second loading / unloading position 324. Alternatively, each of the two second intersections where the transfer path 300 and the second reagent container storage mechanism 32 intersect is the above-mentioned second loading / unloading position 324. That is, the second loading / unloading position 324 includes a second left loading / unloading position which is a second intersection along the transfer path 300 closer to the first reagent container storage mechanism 31, and a second right loading / unloading position which is a second intersection along the transfer path 300 farther from the first reagent container storage mechanism 31.
[0042] In the reagent container temporary storage mechanism 51 having a single ring structure, the third junction where the transfer path 300 and the reagent container temporary storage mechanism 51 meet is the aforementioned third loading / unloading position 514. Alternatively, each of the two third intersections where the transfer path 300 and the reagent container temporary storage mechanism 51 intersect is the aforementioned third loading / unloading position 514. That is, the third loading / unloading position 514 includes a third left loading / unloading position 5141 and a third right loading / unloading position 5142. The third left loading / unloading position 5141 is the third intersection close to the first reagent container storage mechanism 31 along the transfer path 300. The third right loading / unloading position 5142 is the third intersection close to the second reagent container storage mechanism 32 along the transfer path 300.
[0043] In the first embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the first loading / unloading position 314 in a mutually contacting state, the aforementioned first left loading / unloading position or the first right loading / unloading position and the aforementioned third left loading / unloading position 5141 in an intersecting state.
[0044] In the second embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the aforementioned first loading / unloading position 314 in a mutually adjacent state, and between the aforementioned first left loading / unloading position or the first right loading / unloading position and the aforementioned third right loading / unloading position 5142 in an intersecting state.
[0045] In the third embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the second loading / unloading position 324 in a mutually contacting state, the second left loading / unloading position or the second right loading / unloading position and the third left loading / unloading position 5141 in an intersecting state.
[0046] In the fourth embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the second loading / unloading position 324 in a mutually adjacent state, and between the second left loading / unloading position or the second right loading / unloading position and the third right loading / unloading position 5142 in an intersecting state.
[0047] In the fifth embodiment, the reagent container transfer mechanism 52 can transfer the reagent container 40 between the first loading / unloading position 314 when they are in contact with each other, the first left loading / unloading position or the first right loading / unloading position when they are in an intersecting state, and the second loading / unloading position 324 when they are in contact with each other, the second left loading / unloading position or the second right loading / unloading position when they are in an intersecting state.
[0048] Preferably, when the transfer path 300 intersects with the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, respectively, the reagent container transfer mechanism 52 transfers the reagent container 40 between the first right loading / unloading position and the third left loading / unloading position 5141. This shortens the transfer path of the reagent container transfer mechanism 52 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent containers 40. Furthermore, by shortening the time that the reagent containers 40 in a low-temperature state are exposed to the external environment, the effect of the external environmental temperature on the reagent contained in the transferred reagent containers 40 is reduced.
[0049] When the transfer path 300 intersects with the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51, respectively, the reagent container transfer mechanism 52 transfers the reagent containers 40 between the second left loading / unloading position and the third right loading / unloading position 5142. This shortens the transfer path of the reagent container transfer mechanism 52 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent containers 40. Furthermore, by shortening the time that the reagent containers 40 in a low-temperature state are exposed to the external environment, the effect of the external environmental temperature on the reagent contained in the transferred reagent containers 40 is reduced.
[0050] Furthermore, the first reagent container storage mechanism 31 is configured to form a plurality of first placement positions 311 for placing reagent containers 40 along the circumferential direction of the first rotation center 315. The first reagent container storage mechanism 31 rotates so that the plurality of first placement positions 311 sequentially pass through the first loading / unloading position 314. Here, the first loading / unloading positions 314 may be first loading / unloading positions 314 in a state where they are in contact with each other, or may be the above-mentioned first left loading / unloading position or the above-mentioned first right loading / unloading position in a state where they intersect.
[0051] Regarding the first reagent container storage mechanism 31 having a single ring structure, the first reagent container storage mechanism 31 is configured to form a plurality of the above-mentioned first placement positions 311 along the first rotation path.
[0052] The first loading / unloading position 314 is provided on the first rotation path described above. The first reagent container storage mechanism 31 rotates to move the target first loading / unloading position 311 to the first loading / unloading position 314. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first loading / unloading position 311 located at the first loading / unloading position 314, or may pick up and transfer the reagent container 40 placed by the target first loading / unloading position 311 located at the first loading / unloading position 314.
[0053] The second reagent container storage mechanism 32 is configured to form a plurality of second placement positions 321 for placing reagent containers 40 along the circumferential direction of a second rotation center 325. The second reagent container storage mechanism 32 described above rotates so that the plurality of second placement positions 321 sequentially pass through the second loading / unloading position 324. Here, the second loading / unloading positions 324 may be second loading / unloading positions 324 in a state where they are in contact with each other, or may be the second left loading / unloading position or the second right loading / unloading position described above in a state where they intersect.
[0054] For the second reagent container storage mechanism 32 with a single ring structure, the second reagent container storage mechanism 32 is configured to form a plurality of second placement positions 321 along the second rotation path.
[0055] The second loading / unloading position 324 is provided on the second rotation path described above. The second reagent container storage mechanism 32 rotates to move the target second placement position 321 to the second loading / unloading position 324. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second placement position 321 located at the second loading / unloading position 324, or may pick up and transfer the reagent container 40 placed at the target second placement position 321 located at the second loading / unloading position 324.
[0056] The reagent container temporary storage mechanism 51 is configured to form a plurality of third placement positions 511 for placing reagent containers 40 along the circumferential direction of a third rotation center 515. The reagent container temporary storage mechanism 51 rotates so that the plurality of third placement positions 511 sequentially pass through a third loading / unloading position 514. Here, the third loading / unloading positions 514 may be third loading / unloading positions 514 that are in contact with each other, or may be the aforementioned third left loading / unloading position 5141 or the aforementioned third right loading / unloading position 5142 that are in an intersecting state.
[0057] The reagent container temporary storage mechanism 51 having a single ring structure is configured to form a plurality of third placement positions 511 along the third rotation path.
[0058] The third loading / unloading position 514 is provided on the aforementioned third rotation path. The reagent container temporary storage mechanism 51 rotates to move the target third loading / unloading position 511 to the third loading / unloading position 514. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third loading / unloading position 511 located at the third loading / unloading position 514, or may pick up and transfer the reagent container 40 placed at the target third loading / unloading position 511 located at the third loading / unloading position 514.
[0059] 1 again, in the second embodiment, the first reagent container storage mechanism 31 has a double ring structure and includes a first inner storage disk 312 and a first outer storage disk 313. The first inner storage disk 312 is located inside the first outer storage disk 313.
[0060] The first storage inner platen 312 has a first inner loading / unloading position 3122 corresponding to the transfer path 300 of the reagent container transfer mechanism 52. The first storage inner platen 312 rotates around a first rotation center 315, and allows the reagent containers 40 carried thereon to pass through the first inner loading / unloading position 3122 in sequence.
[0061] The first outer storage panel 313 has a first outer loading / unloading position 3132 corresponding to the transfer path 300. The first outer storage panel 313 rotates around a first rotation center 315, and allows the reagent containers 40 carried thereon to pass through the first outer loading / unloading position 3132 in sequence.
[0062] The second reagent container storage mechanism 32 has a double ring structure and includes a second inner storage plate 322 and a second outer storage plate 323. The second inner storage plate 322 is located inside the second outer storage plate 323.
[0063] The second storage inner platen 322 has a second inner access position 3222 corresponding to the transfer path 300. The second storage inner platen 322 can rotate about a second rotation center 325 to drive the reagent container 40 carried thereon through the second inner access position 3222.
[0064] The second outer storage panel 323 has a second outer access position 3232 corresponding to the transfer path 300. The second outer storage panel 323 can rotate about a second rotation center 325 to drive the reagent container 40 carried thereon through the second outer access position 3232.
[0065] The reagent container temporary storage mechanism 51 has a double ring structure and includes an inner temporary storage plate 512 and an outer temporary storage plate 513. The inner temporary storage plate 512 is located inside the outer temporary storage plate 513.
[0066] The temporary storage inner platen 512 has a third inner access position 5122 corresponding to the transfer path 300. The temporary storage inner platen 512 can rotate around a third rotation center 515 to drive the reagent container 40 held therein through the third inner access position 5122.
[0067] The temporary storage outer board 513 has a third outer access position 5132 corresponding to the transfer path 300. The temporary storage outer board 513 can rotate around a third rotation center 515 to drive the reagent container 40 carried thereon through the third outer access position 5132.
[0068] The first inner loading / unloading position 3122, the first outer loading / unloading position 3132, the second inner loading / unloading position 3222, the second outer loading / unloading position 3232, the third inner loading / unloading position 5122, and the third outer loading / unloading position 5132 are each located below the transfer path 300. The reagent container transfer mechanism 52 may be used to transport reagent containers 40 between the first inner loading / unloading position 3122 or the first outer loading / unloading position 3132 and the third inner loading / unloading position 5122 or the third outer loading / unloading position 5132, and / or may be used to transfer reagent containers 40 between the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 and the third inner loading / unloading position 5122 or the third outer loading / unloading position 5132.
[0069] In other embodiments, the first reagent container storage mechanism 31 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. The second reagent container storage mechanism 32 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. The reagent container temporary storage mechanism 51 may be a single-ring structure, a double-ring structure, or a polycyclic structure having at least three rings. This will not be further described here.
[0070] In one embodiment, the transfer path 300 is single-stage and parallel to the center line 200 so that the reagent container transfer mechanism 52 can more efficiently transfer reagent containers between the first reagent container storage mechanism 31, the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51.
[0071] Furthermore, the transfer path 300 of the reagent container transfer mechanism 52 is parallel to the center line 200 , intersects with the center line 200 , or intersects with an extension of the center line 200 .
[0072] Preferably, the transfer path 300 is parallel to the center line 200 so that the reagent container transfer mechanism 52 can efficiently transfer the reagent container 40 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51 over the shortest transfer distance, and / or transfer the reagent container 40 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51.
[0073] In another embodiment, the transport path 300 includes at least two interconnected sub-transport paths, where at least one sub-transport path is not co-linear with another adjacent sub-transport path.
[0074] Specifically, for the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, which have a single ring structure, in this embodiment, the aforementioned sub-transfer path includes sub-transfer paths between the third loading / unloading position 514 and the first loading / unloading position 314 and the second loading / unloading position 324.
[0075] Here, the first loading / unloading position 314 may be the aforementioned first tangent point or any of the aforementioned first intersections, the second loading / unloading position 324 may be the aforementioned second tangent point or any of the aforementioned second intersections, and the third loading / unloading position 514 may be the aforementioned third tangent point or any of the aforementioned third intersections.
[0076] In the present embodiment, with respect to the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51 having a double ring structure, the aforementioned sub-transfer paths include a sub-transfer path between the third inner loading / unloading position 5122 and the first inner loading / unloading position 3122 or the first outer loading / unloading position 3132 or the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 or the third outer loading / unloading position 5132, and a sub-transfer path between the third outer loading / unloading position 5132 and the first inner loading / unloading position 3122 or the first outer loading / unloading position The sub-transfer paths include a sub-transfer path between the first inner loading / unloading position 3122 and the first outer loading / unloading position 3132 or the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232, ... outer loading / unloading position 3132 and the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232, and a sub-transfer path between the second inner loading / unloading position 3222 and the second outer loading / unloading position 3232.
[0077] Here, the first inner insertion / extraction position 3122 may be a first tangent point or any of the first inner intersection points, the first outer insertion / extraction position 3132 may be any of the first outer intersection points, the second inner insertion / extraction position 3222 may be a second tangent point or any of the second inner intersection points, the second outer insertion / extraction position 3232 may be any of the second outer intersection points, the third inner insertion / extraction position 5122 may be a third tangent point or any of the third inner intersection points, and the third outer insertion / extraction position 5132 may be any of the third outer intersection points.
[0078] Furthermore, in the first reagent container storage mechanism 31 having a double ring structure, the connection between the first inner loading / unloading position 3122 and the first rotation center 315 and the connection between the first outer loading / unloading position 3132 and the first rotation center 315 form a first included angle 400.
[0079] Specifically, the first contact point where the transfer path 300 and the first storage inner panel 312 meet is the above-mentioned first inner loading / unloading position 3122. Alternatively, the two first inner intersection points where the transfer path 300 and the first storage inner panel 312 intersect are each the above-mentioned first inner loading / unloading position 3122.
[0080] The two first outer points where the transfer path 300 and the first outer storage panel 313 intersect are the first outer loading / unloading positions 3132 described above.
[0081] The first included angle 400 may be the angle between any of the first outer points, the first tangential points, and the first rotation center 315, or may be the angle between any of the first outer points, any of the first inner intersection points, and the first rotation center 315.
[0082] Preferably, along the longitudinal direction of the transfer path 300, the first inner loading / unloading position 3122 is located closer to the first inner intersection point of the second reagent container storage mechanism 32, and the first outer loading / unloading position 3132 is located closer to one outer point of the second reagent container storage mechanism 32. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent containers 40 between the first inner loading / unloading position 3122 or the first outer loading / unloading position 3132 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent containers 40.
[0083] In the second reagent container storage mechanism 32 having a double ring structure, the connection between the second inner access position 3222 and the second rotation center 325 and the connection between the second outer access position 3232 and the second rotation center 325 form a second included angle 500.
[0084] Specifically, the second contact point where the transfer path 300 contacts the second storage inner panel 322 is the aforementioned second storage inner panel 3222. Alternatively, the two second inner intersection points where the transfer path 300 intersects with the second storage inner panel 322 are the aforementioned second inner loading / unloading positions 3222, respectively.
[0085] The two second outer points where the transfer path 300 and the second outer storage panel 323 intersect are the second outer loading / unloading positions 3232 described above.
[0086] The second included angle 500 may be the angle between any of the second outer points, the second tangential points, and the second pivot center 325, or may be the angle between any of the second outer points, the second inner intersection points, and the second pivot center 325.
[0087] Preferably, along the longitudinal direction of the transfer path 300, the second inner loading / unloading position 3222 is located closer to the second inner intersection of the first reagent container storage mechanism 31, and the second outer loading / unloading position 3232 is located closer to the second outer intersection of the first reagent container storage mechanism 31. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent containers 40 between the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent containers 40.
[0088] In the reagent container temporary storage mechanism 51 having a double ring structure, the connection between the third inner access position 5122 and the third rotation center 515 and the connection between the third outer access position 5132 and the third rotation center 515 form a third included angle 600.
[0089] Specifically, the third contact point where the transfer path 300 meets the temporary storage inner disk 512 is the third inner loading / unloading position 5122. Alternatively, the two third inner intersection points where the transfer path 300 intersects with the temporary storage inner disk 512 are the third inner loading / unloading positions 5122 described above.
[0090] The two third outer points where the transfer route 300 and the temporary storage outer board 513 intersect are the third outer loading / unloading positions 5132 described above.
[0091] The third included angle 600 may be the angle between any of the third outer points, the third tangential points, and the third rotation center 515, or may be the angle between any of the third outer points, the third inner intersection points, and the third rotation center 515.
[0092] Furthermore, the openings of the first and second included angles 400 and 500 face the temporary reagent container storage mechanism 51 and are located on the side away from the reaction disk 20, and the opening of the third included angle 600 faces the reaction disk 20, so that the third rotation center 515 is located on the side of the transfer path 300 away from the reaction disk 20. This allows the temporary reagent container storage mechanism to be integrated into the stage 10 and positioned in a space surrounded by the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reaction disk 20, and the temporary reagent container storage mechanism 51 to be located on one side of the sample analyzer 100. This makes it easy for an operator to insert or remove reagent containers 40 into or from the temporary reagent container storage mechanism 51.
[0093] In one embodiment, along the longitudinal direction of the transfer path 300, when the reagent container transfer mechanism 52 transfers the reagent container 40 between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51, the third inner loading / unloading position 5122 is located closer to the third inner intersection of the second reagent container storage mechanism 32, and the third outer loading / unloading position 5132 is located closer to the third outer intersection of the second reagent container storage mechanism 32. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the second inner loading / unloading position 3222 or the second outer loading / unloading position 3232 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40.
[0094] In one embodiment, the third inner loading / unloading position 5122 and the third outer loading / unloading position 5132 are both located closer to the first reagent container storage mechanism 31 or closer to the second reagent container storage mechanism 32. As a result, the reagent container temporary storage 51 shares a single reagent container access port corresponding to the third inner loading / unloading position 5122 and the third outer loading / unloading position 5132, which makes it possible to effectively control the size of the reagent container access port, thereby reducing temperature convection between the inner cavity of the reagent container temporary storage mechanism 51 and the outside when transferring reagent containers, and further reducing the impact of temperature changes during reagent container transfer on the reagent containers stored in the reagent container temporary storage mechanism 51.
[0095] Along the longitudinal direction of the transfer path 300, when the reagent container transfer mechanism 52 transfers the reagent container 40 between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51, the third inner loading / unloading position 5122 is located closer to the third inner intersection of the first reagent container storage mechanism 31, and the third outer loading / unloading position 5132 is located closer to the third outer intersection of the first reagent container storage mechanism 31. This minimizes the transfer distance when the reagent container transfer mechanism 52 transfers the reagent container 40 between the first inner loading / unloading position 3122 or the first outer loading / unloading position 3132 and the reagent container temporary storage mechanism 51, thereby improving the transfer efficiency of the reagent container 40.
[0096] Furthermore, in one embodiment, the centerline 200 and the third pivot point 515 are located on opposite sides of the transfer path 300, respectively.
[0097] In another embodiment, the third pivot center 515 is located directly below the transfer path 300. That is, in a plan view, the third pivot center 515 is superimposed on the transfer path 300.
[0098] In other embodiments, the third pivot point 515 is located between the centerline 200 and the transfer path 300 .
[0099] Furthermore, the first storage inner platen 312 is configured to form a plurality of first internal placement positions 3121 for placing the reagent containers 40 along the circumferential direction of the first rotation center 315. The first storage inner platen 312 rotates so that the plurality of first internal placement positions 3121 sequentially pass through the first internal loading / unloading position 3122 described above.
[0100] In the first reagent container storage mechanism 31 having a double ring structure, the first storage inner plate 312 is configured to form a plurality of the above-mentioned first inner placement positions 3121 along the first inner rotation path.
[0101] The first inner loading / unloading position 3122 is provided on the first inner rotation path described above. The first inner storage plate 312 rotates to move the target first inner loading / unloading position 3121 to the first inner loading / unloading position 3122 described above. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first inner loading / unloading position 3121 located at the first inner loading / unloading position 3122, or may pick up and transfer the reagent container 40 placed at the target first inner loading / unloading position 3121 located at the first inner loading / unloading position 3122.
[0102] The first storage outer platen 313 forms a plurality of first outer placement positions 3131 for placing the reagent containers 40 along the circumferential direction of the first rotation center 315. The first storage outer platen 313 rotates so that the plurality of first outer placement positions 3131 sequentially pass through the first outer loading / unloading position 3132.
[0103] In the first reagent container storage mechanism 31 having a double ring structure, the first outer storage plate 313 is configured to form a plurality of the above-mentioned first outer placement positions 3131 along the first outer rotation path.
[0104] The first outer loading / unloading position 3132 is provided on the first outer rotation path described above. The first outer storage board 313 rotates to move the target first outer placement position 3131 to the first inner loading / unloading position 3122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target first outer placement position 3131 located at the first outer loading / unloading position 3132, or may pick up and transfer the reagent container 40 placed at the target first outer placement position 3131 located at the first outer loading / unloading position 3132.
[0105] In one embodiment of the first reagent container storage mechanism 31 having a double ring structure, the first inner storage plate 312 and the first outer storage plate 313 rotate synchronously at the same rotation speed. That is, when the first inner storage plate 312 rotates, the first outer storage plate 313 also rotates synchronously at the same rotation speed along with the first inner storage plate 312. Alternatively, when the first outer storage plate 313 rotates, the first inner storage plate 312 also rotates synchronously at the same rotation speed along with the first outer storage plate 313.
[0106] In another embodiment, the first inner storage disk 312 and the first outer storage disk 313 rotate independently of each other. That is, when the first inner storage disk 312 rotates, the first outer storage disk 313 may remain stationary, or may rotate at the same or a different rotational speed as the first inner storage disk 312. Alternatively, when the first outer storage disk 313 rotates, the first inner storage disk 312 may remain stationary, or may rotate at the same or a different rotational speed as the first outer storage disk 313.
[0107] Furthermore, the second storage inner platen 322 is configured to form a plurality of second internal placement positions 3221 for placing the reagent containers 40 along the circumferential direction of the second rotation center 325. The second storage inner platen 322 rotates so that the plurality of second internal placement positions 3221 pass through the second internal loading / unloading position 3222 in sequence.
[0108] For the second reagent container storage mechanism 32 having a double ring structure, the second storage inner plate 322 is configured to form a plurality of the above-mentioned second inner placement positions 3221 along a second inner rotation path.
[0109] The second inner loading / unloading position 3222 is provided on the second inner rotation path. The second inner storage plate 322 rotates to move the target second inner placement position 3221 to the second inner loading / unloading position 3222. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second inner placement position 3221 located at the second inner loading / unloading position 3222, or may pick up and transfer the reagent container 40 placed at the target second inner placement position 3221 located at the second inner loading / unloading position 3222.
[0110] The second outer storage plate 323 is configured to form a plurality of second outer placement positions 3231 for placing the reagent containers 40 along the circumferential direction of the second rotation center 325. The second outer storage plate 323 rotates so that the plurality of second outer placement positions 3231 sequentially pass through the second outer loading / unloading position 3232.
[0111] In the second reagent container storage mechanism 32 having a double ring structure, the second outer storage plate 323 is configured to form a plurality of second outer placement positions 3231 along the second outer rotation path.
[0112] The second outer loading / unloading position 3232 is provided on the second outer rotation path. The second outer storage board 323 rotates to move the target second outer placement position 3231 to the second inner loading / unloading position 3222. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target second outer placement position 3231 located at the second outer loading / unloading position 3232, or may pick up and transfer the reagent container 40 placed at the target second outer placement position 3231 located at the second outer loading / unloading position 3232.
[0113] In one embodiment of the second reagent container storage mechanism 32 having a double ring structure, the second inner storage plate 322 rotates synchronously at the same rotation speed as the second outer storage plate 323. That is, when the second inner storage plate 322 rotates, the second outer storage plate 323 also rotates synchronously at the same rotation speed along with the second inner storage plate 322. Alternatively, when the second outer storage plate 323 rotates, the second inner storage plate 322 also rotates synchronously at the same rotation speed along with the second outer storage plate 323.
[0114] In another embodiment, the second inner storage disc 322 and the second outer storage disc 323 rotate independently of each other. That is, when the second inner storage disc 322 rotates, the second outer storage disc 323 may remain stationary, or may rotate at the same or a different rotational speed as the second inner storage disc 322. Alternatively, when the second outer storage disc 323 rotates, the second inner storage disc 322 may remain stationary, or may rotate at the same or a different rotational speed as the second outer storage disc 323.
[0115] Furthermore, the temporary storage inner platen 512 is configured to form a plurality of third internal placement positions 5121 for placing the reagent containers 40 along the circumferential direction of the third rotation center 515. The temporary storage inner platen 512 rotates such that the plurality of third internal placement positions 5121 sequentially pass through the third internal loading / unloading position 5122.
[0116] In the reagent container temporary storage mechanism 51 having a double ring structure, the temporary storage inner plate 512 is configured to form a plurality of the above-mentioned third inner placement positions 5121 along the third inner rotation path.
[0117] The third inner loading / unloading position 5122 is provided on the third inner rotation path described above. The temporary storage inner platen 512 rotates to move the target third inner placement position 5121 to the third inner loading / unloading position 5122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third inner placement position 5121 located at the third inner loading / unloading position 5122, or may pick up and transfer the reagent container 40 placed at the target third inner placement position 5121 located at the third inner loading / unloading position 5122.
[0118] The temporary storage outer platen 513 is configured to form a plurality of third outer placement positions 5131 for placing the reagent containers 40 along the circumferential direction of the third rotation center 515. The temporary storage outer platen 513 rotates such that the plurality of third outer placement positions 5131 sequentially pass through the third outer loading / unloading position 5132.
[0119] In the reagent container temporary storage mechanism 51 having a double ring structure, the temporary storage outer plate 513 is configured to form a plurality of the above-mentioned third outer placement positions 5131 along the third outer rotation path.
[0120] The third outer loading / unloading position 5132 is provided on the third outer rotation path. The temporary storage outer platen 513 rotates to move the target third outer placement position 5131 to the third inner loading / unloading position 5122. At this time, the reagent container transfer mechanism 52 may load one target reagent container 40 into the target third outer loading / unloading position 5131 located at the third outer loading / unloading position 5132, or may pick up and transfer the reagent container 40 placed at the target third outer loading / unloading position 5131 located at the third outer loading / unloading position 5132.
[0121] In one embodiment of the reagent container temporary storage mechanism 51 having a double ring structure, the temporary storage inner platen 512 and the temporary storage outer platen 513 rotate synchronously at the same rotation speed. That is, when the temporary storage inner platen 512 rotates, the temporary storage outer platen 513 also rotates synchronously at the same rotation speed along with the temporary storage inner platen 512. Alternatively, when the temporary storage outer platen 513 rotates, the temporary storage inner platen 512 also rotates synchronously at the same rotation speed along with the temporary storage outer platen 513.
[0122] In another embodiment, the temporary storage inner disc 512 and the temporary storage outer disc 513 rotate independently of each other. That is, when the temporary storage inner disc 512 rotates, the temporary storage outer disc 513 may remain stationary or may rotate at the same or a different rotational speed as the temporary storage inner disc 512. Alternatively, when the temporary storage outer disc 513 rotates, the temporary storage inner disc 512 may remain stationary or may rotate at the same or a different rotational speed as the temporary storage outer disc 513.
[0123] Therefore, as described above, in the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51 having a double-ring structure, the reagent container transfer mechanism 52 is used to transfer reagent containers 40 between the first inner access position 3122 or the first outer access position 3132 and the third inner access position 5122. Alternatively, the reagent container transfer mechanism 52 is used to transfer reagent containers 40 between the first inner access position 3122 or the first outer access position 3132 and the third outer access position 5132. Alternatively, the reagent container transfer mechanism 52 is used to transfer reagent containers 40 between the second inner access position 3222 or the second outer access position 3232 and the third inner access position 5122. Alternatively, the aforementioned reagent container transfer mechanism 52 is used to transfer reagent containers 40 between the second inner access position 3222 or the second outer access position 3232 and the aforementioned third outer access position 5132 .
[0124] Furthermore, in some embodiments, the reagent container transfer mechanism 52 may be used to transfer reagent containers 40 between the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 .
[0125] Furthermore, a vertical symmetry line 700 is formed that passes through the fourth rotation center 21 and is perpendicular to the center line 200. The third rotation center 515 is deviated from the vertical symmetry line 700 and approaches the first reagent container storage mechanism 31 or the second reagent container storage mechanism 32.
[0126] Specifically, after the reaction disk 20 is attached to the stage 10 with the fourth rotation center 21 as a reference, and the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are attached to the reaction disk 20 as a reference, the available space remaining between the reaction disk 20 and the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 is limited. Therefore, after the reagent container temporary storage mechanism 51 is attached to the stage 10 with the third rotation center 515 as a reference, the third rotation center 515 moves away from the vertical symmetry line 700 and approaches the first reagent container storage mechanism 31 or the second reagent container storage mechanism 32.
[0127] Furthermore, in one embodiment, the vertical line of symmetry 700 and the foot of centerline 200 are located at the midpoint of centerline 200 .
[0128] Specifically, the first and second rotation centers 315, 325 are symmetrically distributed on both sides of the vertical symmetry line 700 such that the first and second reagent container storage mechanisms 31, 32 are symmetrically disposed on both sides of the vertical symmetry line 700. The first and second rotation centers 315, 325, and the fourth rotation center 21 surround each other to form an isosceles triangle.
[0129] Furthermore, a horizontal symmetry line 800 is formed that passes through the fourth pivot center 21 and is parallel to the center line 200. The sample analyzer 100 further includes a sample transport mechanism 70 for transporting sample containers. The center line 200 and the sample transport mechanism 70 are located on either side of the horizontal symmetry line 800.
[0130] Specifically, the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51 are all provided on the same side (one side) of the horizontal symmetry line 800, and the sample transport mechanism 70 is located on the other side of the horizontal symmetry line 800. This allows the operator to easily take reagent containers 40 in and out of the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, and the reagent container temporary storage mechanism 51, and the sample transport mechanism 70 can smoothly transport the sample containers.
[0131] Furthermore, the reagent container transfer mechanism 52 includes a take-in / take-out device 521 , a rotation drive device 522 , a lift drive device 523 and a horizontal drive device 524 .
[0132] The take-in / take-out device 521 is for taking in and out the reagent container 40, and rotates along the rotation axis under the drive of the rotation drive device 522.
[0133] Specifically, the take-in / take-out device 521 can take out and release the reagent container 40 .
[0134] In one embodiment, the transfer device 521 is a gripper for clamping the reagent container 40 in order to transfer the reagent container 40. The gripper can adjust the angle at which it clamps or releases the reagent container 40 under the drive of the rotation drive device 522 in order to transfer the reagent container 40 more efficiently.
[0135] Specifically, since the transfer path 300 of the reagent container transfer mechanism 52 is located off the above-mentioned center line 200, each loading / unloading position in the first reagent container storage mechanism 31 has a different phase angle with respect to the first rotation center 315, each loading / unloading position in the second reagent container storage mechanism 32 also has a different phase angle with respect to the second rotation center 325, and each loading / unloading position in the reagent container temporary storage mechanism 51 also has a different phase angle with respect to the third rotation center 515. Therefore, when clamping or releasing a reagent container 40 at different loading / unloading positions, the gripper needs to adjust the clamping or releasing angle under the drive of the rotation drive device 522.
[0136] In another embodiment, the dispenser 521 is a suction nozzle, which is connected to a pump via a conduit, which operates and controls the suction nozzle via the conduit to aspirate or expel the reagent container 40.
[0137] Specifically, since the transfer path 300 of the reagent container transfer mechanism 52 is arranged off the center line 200, each loading and unloading position in the first reagent container storage mechanism 31 has a different phase angle with respect to the first rotation center 315, each loading and unloading position in the second reagent container storage mechanism 32 also has a different phase angle with respect to the second rotation center 325, and each loading and unloading position in the reagent container temporary storage mechanism 51 also has a different phase angle with respect to the third rotation center 515. Therefore, the nozzle is arranged off the rotation axis of the rotary drive device 522 so that it can clamp or release the reagent container 40 at different loading and unloading positions.
[0138] The lifting drive device 523 drives the lifting and lowering of the loading / unloading device 521. The lifting drive device 523 enables the loading / unloading device 521 to descend to each loading / unloading position to load or unload a reagent container 40, and then move upward after picking up or releasing the reagent container 40 to move away from the first reagent container storage mechanism 31, the second reagent container storage mechanism 32, or the reagent container temporary storage mechanism 51.
[0139] The horizontal drive device drives the loading / unloading device 521 to move it between the first loading / unloading position 314 and the third loading / unloading position 514 along the transfer path 300, thereby transferring the reagent container 40 between the reagent container temporary storage mechanism 51 and the first reagent container storage mechanism 31. The horizontal drive device is also used to drive the loading / unloading device 521 to move it between the second loading / unloading position 324 and the third loading / unloading position 514, thereby transferring the reagent container 40 between the reagent container temporary storage mechanism 51 and the second reagent container storage mechanism 32.
[0140] Specifically, the horizontal drive device 524 drives the loading / unloading device 521 to transfer the reagent container 40 along the transfer path 300, or drives the loading / unloading device 521 to move along the transfer path 300 to reach the target loading / unloading position and pick up the reagent container 40.
[0141] In one embodiment, the loading / unloading device 521 is provided at the output end of the rotary drive device 522 , the rotary drive device 522 is provided at the output end of the lift drive device 523 , and the lift drive device 523 is provided at the output end of the horizontal drive device 524 .
[0142] In another embodiment, the loading / unloading device 521 is provided at the output end of the lifting drive device 523 , the lifting drive device 523 is provided at the output end of the rotation drive device 522 , and the rotation drive device 522 is provided at the output end of the horizontal drive device 524 .
[0143] Furthermore, the reagent container transfer mechanism 52 further includes a collection box 60. A collection port 61 of the collection box 60 is provided below the transfer path 300. This allows the reagent container transfer mechanism 52 to discard the reagent container 40 from the collection port 61 simply by moving along the transfer path 300. This simplifies the movement path of the reagent container transfer mechanism 52, making it easier to discard the reagent container 40 and improving the efficiency of loading the reagent container 40.
[0144] The take-in / take-out device 521 can be moved above the recovery port 61 by the drive of the horizontal drive device 524, and can also collect the reagent container 40 by disposing of the reagent container 40 from the recovery port 61 into the recovery box 60. Here, the collected reagent container 40 may be an empty reagent container 40, or may be a reagent container 40 that also contains a reagent.
[0145] Furthermore, in one embodiment, the recovery port 61 is located between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51.
[0146] In another embodiment, the recovery port 61 is located between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51.
[0147] Preferably, the collection port 61 and the third pivot center 515 are distributed on both sides of the vertical symmetrical line 700 so that the collection box 60 and the reagent container temporary storage mechanism 51 are disposed on both sides of the vertical symmetrical line 700. This allows the collection box 60 to be positioned by fully utilizing the space between the first reagent container storage mechanism 31 and the reagent container temporary storage mechanism 51 or the space between the second reagent container storage mechanism 32 and the reagent container temporary storage mechanism 51. As a result, the collection box 60 is compactly stored in the sample analyzer 100 and is located away from the sample transport mechanism 70 of the sample analyzer 100. This allows the operator to easily remove the reagent containers 40 collected in the collection box 60.
[0148] Furthermore, the reaction plate 20 can accommodate a plurality of reaction vessels, which contain specimens (detection samples) and reagents injected from the first reagent vessel storage mechanism 31 and / or the second reagent vessel storage mechanism 32, and incubate the mixture of the specimen and reagents via the reaction plate 20.
[0149] Furthermore, the reaction disk 20 includes a first reagent dispensing position 22, a second reagent dispensing position 23, a third reagent dispensing position 24, and a fourth reagent dispensing position 25.
[0150] The first reagent container storage mechanism 31 includes a first reagent aspirating position 316 and a second reagent aspirating position 317 .
[0151] 1 and 4, the sample analyzer 100 further includes a first reagent injection mechanism 91. The first reagent injection mechanism 91 transfers and injects the reagent from the reagent container 40 placed in the first reagent container storage mechanism 31 into the reaction container placed on the reaction disk 20.
[0152] The first reagent injection mechanism 91 includes a first reagent needle 911 and a second reagent needle that operate independently.
[0153] The first reagent needle 911 is used to aspirate reagent from a reagent container 40 located at either the first reagent suction position 316 or the second reagent suction position 317, and to dispense and inject it along a first straight line 913 into a reaction container located at either the first reagent discharge position 22 or the second reagent discharge position 23.
[0154] The second reagent needle is used to aspirate reagent from a reagent container 40 located at the other of the first reagent suction position 316 or the second reagent suction position 317 and to dispense and inject it along a second straight line 914 into a reaction container located at the other of the first reagent discharge position 22 or the second reagent discharge position 23.
[0155] The reaction disk 20 rotates to move the two target reaction containers to the first reagent dispensing position 22 and the second reagent dispensing position 23, respectively. Then, after the first reagent container storage mechanism 31 rotates to move the two target reagent containers 40 to the first reagent aspirating position 316 and the second reagent aspirating position 317, respectively, the first reagent needle 911 aspirates reagent from one target reagent container 40 located at either the first reagent aspirating position 316 or the second reagent aspirating position 317, and transfers the aspirated reagent along the first straight line 913 to inject it into one target reaction container located at either the first reagent dispensing position 22 or the second reagent dispensing position 23.
[0156] The second reagent needle aspirates reagent from a target reagent container 40 located at the other of the first reagent aspirating position 316 or the second reagent aspirating position 317, and transports the aspirated reagent along the second straight line 914 to inject it into a target reaction container located at the other of the first reagent dispensing position 22 or the second reagent dispensing position 23.
[0157] Compared to the reagent injection method of the conventional sample analyzer 100, the present invention significantly improves the efficiency of reagent injection into reaction vessels by using an independently operating first reagent needle 911 to transfer reagent along a first straight line 913 and an independently operating second reagent needle to transfer reagent along a second straight line 914. The first and second reagent needles are prevented from back and forth between aspirating and injecting reagent, and from rotating to transfer and reset the aspirated reagent. This effectively reduces the time the reaction disk 20 waits for the first and second reagent needles to inject reagent, shortens the time the first reagent container storage mechanism 31 waits for the first and second reagent needles to aspirate reagent, and shortens the reagent transfer time and the time it takes for the first and second reagent needles to reset. Furthermore, the independently operating first and second reagent needles can also be controlled to transfer reagent by controlling only the first or second reagent needle as needed.
[0158] Referring again to Figure 2, in one embodiment, the first reagent container storage mechanism 31 has a single ring structure. The first loading positions 311 transport reaction containers around a first rotation center 315 along the first rotation path described above.
[0159] 1, in another embodiment, the first reagent container storage mechanism 31 has a double-ring structure, and the first storage inner plate 312 is configured to form a plurality of first inner mounting positions 3121 along a first inner rotation path. Each of the first inner mounting positions 3121 can accommodate one reagent container 40.
[0160] The first outer storage board 313 is configured to form a plurality of first outer placement positions 3131 along the first outer rotation path. Each of the first outer placement positions 3131 can place one reagent container 40 thereon.
[0161] Furthermore, in a more specific embodiment, the first reagent aspirating position 316 is provided on the first internal rotation path of the first storage inner platen 312. The plurality of first internal placement positions 3121 move along the first internal rotation path and sequentially pass the first reagent aspirating position 316. The second reagent aspirating position 317 is provided on the first external rotation path of the first storage outer platen 313. The plurality of first external placement positions 3131 move along the first external rotation path and sequentially pass the second reagent aspirating position 317.
[0162] In another more specific embodiment, the first reagent aspirating position 316 is provided on the first outer rotation path of the first outer storage platen 313, and the multiple first outer placement positions 3131 move along the first outer rotation path and sequentially pass the first reagent aspirating position 316. The second reagent aspirating position 317 is provided on the first inner rotation path of the first inner storage platen 312, and the multiple first inner placement positions 3121 move along the first inner rotation path and sequentially pass the second reagent aspirating position 317.
[0163] In one embodiment, the first inner storage disk 312 and the first outer storage disk 313 maintain synchronous rotation.
[0164] In another embodiment, the first inner storage disc 312 is rotatable independently of the first outer storage disc 313. That is, when the first inner storage disc 312 rotates, the first outer storage disc 313 may remain stationary, or may rotate at the same or a different rotational speed as the first inner storage disc 312. Alternatively, when the first outer storage disc 313 rotates, the first inner storage disc 312 may remain stationary, or may rotate at the same or a different rotational speed as the first outer storage disc 313.
[0165] Furthermore, the independently rotatable first storage inner plate 312 can be controlled to move the target reagent container 40 directly to the first reagent suction position 316 or the second reagent suction position 317 corresponding to the first reagent needle 911, depending on the type of reagent to be aspirated in the reagent container 40 placed in the first inner placement position 3121.
[0166] The independently rotatable first storage outer plate 313 can be controlled to move the target reagent container 40 directly to the second reagent suction position 317 or the first reagent suction position 316 corresponding to the second reagent needle, depending on the type of reagent to be aspirated in the reagent container 40 placed at the first outer placement position 3131.
[0167] The first storage inner plate 312 and the first storage outer plate 313, which can rotate independently, can make it easier for the first reagent needle 911 and the second reagent needle to aspirate the reagent, compared to the first storage inner plate 312 and the first storage outer plate 313, which maintain synchronous rotation.
[0168] Furthermore, the reaction disc 20 includes a reaction inner tray 26 and a reaction outer tray 27. The reaction inner tray 26 is provided inside the reaction outer tray 27.
[0169] The reaction inner tray 26 is configured to form a plurality of fourth inner placement positions 261 along the fourth inner rotation path. Each of the fourth inner placement positions 261 can place one reaction vessel therein.
[0170] The outer reaction tray 27 is configured to form a plurality of fourth outer placement positions 271 along the fourth outer rotation path. Each of the fourth outer placement positions 271 can place one reaction vessel thereon.
[0171] Furthermore, in a more specific embodiment, the first reagent discharge position 22 is provided on the aforementioned fourth internal rotation path of the reaction inner tray 26, and the multiple fourth internal placement positions 261 move along the aforementioned fourth internal rotation path and pass through the first reagent discharge position 22 sequentially.
[0172] The second reagent ejection position 23 is provided on the aforementioned fourth outer rotation path of the reaction outer tray 27, and the multiple fourth outer placement positions 271 move along the aforementioned fourth outer rotation path and pass through the aforementioned second reagent ejection position 23 in sequence.
[0173] In another more specific embodiment, the first reagent ejection position 22 is provided on the aforementioned fourth outer rotation path of the reaction outer tray 27, and multiple fourth outer placement positions 271 move along the aforementioned fourth outer rotation path and pass through the first reagent ejection position 22 sequentially.
[0174] The second reagent ejection position 23 is provided on the aforementioned fourth internal rotation path of the reaction inner tray 26, and the multiple fourth internal placement positions 261 move along the aforementioned fourth internal rotation path and pass through the second reagent ejection position 23 sequentially.
[0175] In one embodiment, the inner reaction tray 26 and the outer reaction tray 27 maintain synchronous rotation.
[0176] In another embodiment, the reaction inner tray 26 is rotatable independently of the reaction outer tray 27. That is, when the reaction inner tray 26 rotates, the reaction outer tray 27 may remain stationary and unmoving, or may rotate at the same or a different rotational speed as the reaction inner tray 26. Alternatively, when the reaction outer tray 27 rotates, the reaction inner tray 26 may remain stationary and unmoving, or may rotate at the same or a different rotational speed as the reaction outer tray 27.
[0177] Furthermore, the independently rotatable inner reaction tray 26 can be controlled so that the target reaction vessel moves directly to the first reagent ejection position 22 or the second reagent ejection position corresponding to the first reagent needle 911, depending on the type of reagent to be injected into the reaction vessel placed in the fourth inner placement position 261.
[0178] The independently rotatable outer reaction tray 27 can be controlled so that the target reaction vessel moves directly to the second reagent ejection position corresponding to the second reagent needle or the first reagent ejection position 22 depending on the type of reagent to be injected into the reaction vessel placed at the fourth outer placement position 271.
[0179] Rather than keeping the reaction inner tray 26 and the reaction outer tray 27 rotating synchronously, the reaction inner tray 26 and the reaction outer tray 27 being able to rotate independently can make it easier to inject reagents using the first reagent needle 911 and the second reagent needle.
[0180] Furthermore, by providing an independently rotatable inner reaction tray 26 and outer reaction tray 27, as well as an independently rotatable first storage inner plate 312 and first outer storage plate 313, and by using an independently operating first reagent needle 911 to inject the reagent placed on the first outer storage plate 313 into a reaction vessel placed on the inner reaction tray 26 or outer reaction tray 27, and by using an independently operating second reagent needle to inject the reagent placed on the first inner storage plate 312 into a reaction vessel placed on the outer reaction tray 27 or inner reaction tray 26, the sample analyzer 100 integrates two independent and parallel reagent supply, dispensing, and detection systems, thereby effectively improving detection efficiency.
[0181] Furthermore, in one embodiment, a first center line 200 is formed between the first pivot center 315 and the third pivot center 515. The first straight line 913 and the second straight line 914 are each parallel to the first center line 200.
[0182] Preferably, the distance from the first straight line 913 to the first center line 200 is equal to the distance from the second straight line 914 to the first center line 200 .
[0183] Furthermore, the time required for the first reagent needle 911 to move along the first straight line 913 from the first reagent suction position 316 to the first reagent discharge position 22 is the same as the time required for the second reagent needle to move along the second straight line 914 from the second reagent suction position 317 to the second reagent discharge position.
[0184] Furthermore, in one embodiment, the first reagent needle 911 and the second reagent needle described above are provided on the stand at a certain distance from each other.
[0185] Furthermore, the first reagent needle 911 is moved up and down in the vertical direction by the lifting drive device 523 so that it can move up and down between one of the first reagent suction position 316 and the second reagent suction position 317, and between one of the first reagent discharge position 22 and the second reagent discharge position.
[0186] Furthermore, the first reagent needle 911 moves horizontally along the direction of the first straight line 913 by a horizontal drive device so that it can move between the first reagent suction position 316 and the first reagent discharge position 22 or the second reagent discharge position, or between the second reagent suction position 317 and the aforementioned second reagent discharge position or the first reagent discharge position 22.
[0187] The second reagent needle is moved up and down vertically by another lifting drive device 523 so that it can move up and down between one of the first reagent suction position 316 and the second reagent suction position 317, and between the first reagent discharge position 22 and the second reagent discharge position.
[0188] Furthermore, the second reagent needle described above is moved horizontally along the direction of a second straight line 914 by yet another horizontal drive device so that it can move between the first reagent suction position 316 and the first reagent discharge position 22 or the second reagent discharge position, or between the second reagent suction position 317 and the second reagent discharge position or the first reagent discharge position 22.
[0189] In another embodiment, the first reagent needle 911 and the second reagent needle are provided on the same stent, and the first reagent needle 911 and the second reagent needle are each moved up and down vertically by a single lifting drive device 523, and are each moved horizontally along a corresponding first straight line 913 and second straight line 914 by a single horizontal drive device.
[0190] Furthermore, the reaction disk 20 further includes a third reagent dispensing position 24 and a fourth reagent dispensing position 25. The reaction disk 20 rotates around the fourth rotation center 21 to drive the plurality of third placement positions 511, so that the reaction disk 20 can pass through the third reagent dispensing position 24 and the fourth reagent dispensing position 25 in sequence.
[0191] The sample analyzer 100 further includes a second reagent injection mechanism 92, which is used to inject reagent from a reagent container 40 placed in the second reagent container storage mechanism 32 into a reaction container placed on the reaction disk 20.
[0192] The second reagent container storage mechanism 32 is provided outside the reaction disk 20 and is capable of holding a plurality of reagent containers 40. The second reagent container storage mechanism 32 is rotatable so that the plurality of reagent containers 40 move in unison along a second rotation path.
[0193] The second reagent container storage mechanism 32 is configured to form a plurality of second placement positions 321 along the second rotation path. Each of the second placement positions 321 can place one reagent container 40 therein.
[0194] The second reagent container storage mechanism 32 includes a third reagent aspirating position 326 and a fourth reagent aspirating position 327. The second reagent container storage mechanism 32 rotates around a second rotation center 325, allowing the multiple second placement positions 321 to pass through the third reagent aspirating position 326 and the fourth reagent aspirating position 327 in sequence.
[0195] The second reagent injection mechanism 92 includes a third reagent needle and a fourth reagent needle that operate independently. The third and fourth reagent needles have the same structure as the first reagent needle 911 and the second reagent needle described above.
[0196] The third reagent needle is used to aspirate reagent in a reagent container 40 located at either the third reagent suction position 326 or the fourth reagent suction position 327, and to transfer and inject the aspirated reagent along the third straight line 923 into a reaction container located at either the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0197] The fourth reagent needle is used to aspirate reagent in a reagent container 40 located at the other of the third reagent suction position 326 or the fourth reagent suction position 327, and to transfer and inject the aspirated reagent along the fourth straight line 924 into a reaction container located at the other of the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0198] After the reaction disk 20 rotates to move the two target reaction vessels to the third reagent dispensing position 24 and the fourth reagent dispensing position 25, respectively, and the second reagent vessel storage mechanism 32 rotates to move the two target reagent vessels 40 to the third reagent suction position 326 and the fourth reagent suction position 327, respectively, the third reagent needle aspirates reagent from the target reagent vessel 40 located at either the third reagent suction position 326 or the fourth reagent suction position 327, and transfers the absorbed reagent along the third straight line 923 to inject it into the target reaction vessel located at either the third reagent dispensing position 24 or the fourth reagent dispensing position 25.
[0199] The fourth reagent needle aspirates reagent from the target reagent container 40 located at the other of the third reagent suction position 326 or the fourth reagent suction position 327, and transfers the absorbed reagent along the fourth straight line 924 to inject it into the target reaction container located at the other of the third reagent discharge position 24 or the fourth reagent discharge position 25.
[0200] As shown in FIG. 2, in one embodiment, the second reagent container storage mechanism 32 is a single ring structure, and multiple second placement positions 321 transport reaction containers along the aforementioned second rotation path around a second rotation center 325.
[0201] Referring again to Figure 1, in another embodiment, the second reagent container storage mechanism 32 has a double ring structure. The second storage inner plate 322 is configured to form a plurality of second internal mounting positions 3221 along the second internal rotation path. Each of the second internal mounting positions 3221 can accommodate one reagent container 40.
[0202] The second outer storage board 323 is configured to form a plurality of second outer placement positions 3231 along the second outer rotation path. Each of the second outer placement positions 3231 can place one reagent container 40 thereon.
[0203] Furthermore, in a more specific embodiment, the third reagent suction position 326 is provided on the aforementioned second internal rotation path of the second storage inner plate 322, and the multiple second internal placement positions 3221 move along the aforementioned second internal rotation path and pass through the third reagent suction position 326 sequentially.
[0204] The fourth reagent suction position 327 is provided on the aforementioned second outer rotation path of the second storage outer platen 323, and the multiple second outer placement positions 3231 move along the aforementioned second outer rotation path and pass through the fourth reagent suction position 327 in sequence.
[0205] In another more specific embodiment, the third reagent suction position 326 is provided on the second external rotation path of the second storage outer platen 323, and the multiple second external placement positions 3231 move along the aforementioned first external rotation path and pass through the third reagent suction position 326 sequentially.
[0206] The fourth reagent suction position 327 is provided on the aforementioned second internal rotation path of the second storage inner plate 322, and the multiple second internal placement positions 3221 move along the aforementioned second internal rotation path and pass through the fourth reagent suction position 327 in sequence.
[0207] In one embodiment, the second inner storage disc 322 and the second outer storage disc 323 maintain synchronous rotation.
[0208] In another embodiment, the second inner storage disc 322 is rotatable independently of the second outer storage disc 323. That is, when the second inner storage disc 322 rotates, the second outer storage disc 323 may remain stationary, or may rotate at the same or a different rotational speed as the second inner storage disc 322. Alternatively, when the second outer storage disc 323 rotates, the second inner storage disc 322 may remain stationary, or may rotate at the same or a different rotational speed as the second outer storage disc 323.
[0209] Furthermore, the independently rotatable second storage inner plate 322 can be controlled to move the target reagent container 40 directly to the third reagent suction position 326 or the fourth reagent suction position 327 corresponding to the aforementioned third reagent needle, depending on the type of reagent to be aspirated in the reagent container 40 placed at the second inner placement position 3221.
[0210] The independently rotatable second storage outer plate 323 can be controlled to move the target reagent container 40 directly to the third reagent suction position 326 or the fourth reagent suction position 327 corresponding to the aforementioned fourth reagent needle, depending on the type of reagent to be aspirated in the reagent container 40 placed at the second outer placement position 3231.
[0211] Furthermore, the reaction disk 20 has a horizontal symmetry line 800 and a vertical symmetry line 700 passing through the third pivot center 515. The horizontal symmetry line 800 and the vertical symmetry line 700 divide the reaction disk 20 into a first quadrant, a second quadrant, a third quadrant, and a fourth quadrant.
[0212] In one embodiment, the first pivot center 315 and the second pivot center 325 are located on either side of the vertical symmetry line 700 and on the same side of the horizontal symmetry line 800. Thus, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are respectively provided in the first and second quadrants outside the reaction disk 20 or in the third and fourth quadrants outside the reaction disk 20.
[0213] In another embodiment, the first and second pivot centers 315, 325 are located on either side of the horizontal symmetry line 800 and on the same side of the vertical symmetry line 700. Thus, the first and second reagent container storage mechanisms 31, 32 are located in the first and fourth quadrants outside the reaction disk 20, or in the second and third quadrants outside the reaction disk 20, respectively.
[0214] Specifically, the reaction disk 20, the first reagent container storage mechanism 31, and the second reagent container storage mechanism 32 are all provided on the stage 10. Moreover, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are located on the same side of the stage 10 to facilitate the attachment and detachment of reagent containers 40 to and from the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32.
[0215] Furthermore, the first rotation center 315 of the first reagent container storage mechanism 31 and the second rotation center 325 of the second reagent container storage mechanism 32 are connected to form a center line 200 .
[0216] The vertical symmetry line 700 and the foot of the centerline 200 are located at the midpoint of the centerline 200 .
[0217] Specifically, the linear distance from the first rotation center 315 to the third rotation center 515 is equal to the linear distance from the second rotation center 325 to the third rotation center 515. As a result, the triangle formed by the lines connecting the three points of the first rotation center 315, the second rotation center 325, and the third rotation center 515 is an isosceles triangle. Moreover, the first reagent container storage mechanism 31 and the second reagent container storage mechanism 32 are distributed symmetrically on both sides of the reaction disk 20 along the vertical line of symmetry 700.
[0218] For ease of description, spatially relative terms such as "above," "above," "on top of," "above," and "on top of" may be used herein to describe the spatial relationship of one element or feature to other elements or features shown in the figures. It should be understood that spatially relative terms are intended to encompass different orientations of an element during use or operation other than the orientation depicted in the figures. For example, if an element in the figures is inverted, an element described as "above other elements or structures" or "on top of other elements or structures" would then be positioned as "below other elements or structures" or "beneath other elements or structures." Thus, the exemplary term "above" can encompass two orientations: "above" and "below." The element may also be positioned in other different ways (rotated 90 degrees or at other orientations) and receive corresponding interpretations of the spatially relative descriptions used herein.
[0219] Furthermore, the use of terms such as "first" and "second" to limit parts is merely to make it easier to distinguish the relevant parts, and unless otherwise stated, the above terms have no special meaning and therefore cannot be understood as limiting the scope of protection of the present application.
[0220] The above is only a preferred embodiment of the present application, and is not used to limit the present application. Those skilled in the art may find various modifications and variations in the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application. [Explanation of symbols]
[0221] 100: Sample analyzer 10: Stage 20: Reaction disc 21: 4th rotation center 22: First reagent dispensing position 23: Second reagent dispensing position 24: Third reagent dispensing position 25: 4th reagent dispensing position 26: Reaction inner tray 261: 4th internal placement position 27: Reaction outer tray 271: 4th outer placement position 31: First reagent container storage mechanism 311: First placement position 312: 1st storage inner panel 3121: First internal placement position 3122: First inner loading / unloading position 313: First storage outer panel 3131: First outer placement position 3132: First outer loading / unloading position 314: First loading / unloading position 315: First rotation center 316: First reagent aspiration position 317: Second reagent aspiration position 32: Second reagent container storage mechanism 321: Second placement position 322:Second storage inner panel 3221: Second internal placement position 3222: Second inner loading / unloading position 323: Second storage outer panel 3231: Second outer placement position 3232: Second outer loading / unloading position 324: Second loading / unloading position 325: Second center of rotation 326: Third reagent aspiration position 327: 4th reagent aspiration position 40: Reagent container 51: Reagent container temporary storage mechanism 511: Third placement position 512:Temporary storage internal board 5121: Third internal placement position 5122: Third inner loading / unloading position 513:Temporary storage outer disc 5131: Third outer placement position 5132: Third outer loading / unloading position 514: Third loading / unloading position 5141: Third left loading / unloading position 5142: Third right loading / unloading position 515: Third center of rotation 52: Reagent container transfer mechanism 521: Loading and unloading device 522: Rotational drive device 523: Lifting drive device 524: Horizontal drive unit 60: Collection box 61: Collection port 70: Sample transport mechanism 91: First reagent injection mechanism 911: First reagent needle 913: 1st straight line 914:Second straight line 92: Second reagent injection mechanism 923: Third straight line 924: 4th straight line 200: Center line 300: Forwarding route 400: 1st included angle 500: 2nd included angle 600: 3rd included angle 700: Vertical symmetry line 800: Horizontal symmetry line
Claims
1. A sample analyzer, comprising: a reaction disk (20) provided on a stage (10); a first reagent container storage mechanism (31); a second reagent container storage mechanism (32); a reagent container temporary storage mechanism (51) on which a reagent container (40) is placed and which is located between the first reagent container storage mechanism (31) and the second reagent container storage mechanism (32); a reagent container transfer mechanism (52); a first pivot center (315) of the first reagent container storage mechanism (31) and a second pivot center (325) of the second reagent container storage mechanism (32) are connected to form a center line (200); a third rotation center (515) of the reagent container temporary storage mechanism (51) and a fourth rotation center (21) of the reaction disk (20) are located on both sides of the center line (200), respectively; A sample analysis apparatus characterized in that the reagent container transfer mechanism (52) is used to transfer reagent containers (40) between the first reagent container storage mechanism (31) and the reagent container temporary storage mechanism (51), and / or between the second reagent container storage mechanism (32) and the reagent container temporary storage mechanism (51).
2. The sample analysis device of claim 1, characterized in that the transfer path (300) of the reagent container transfer mechanism (52) is parallel to the center line (200), and the number of the first loading / unloading position (314) of the first reagent container storage mechanism (31), the second loading / unloading position (324) of the second reagent container storage mechanism (32), and the third loading / unloading position (514) of the reagent container storage mechanism (51) is at least one each.
3. The first reagent container storage mechanism (31) includes a first storage inner plate (312) and a first storage outer plate (313), and the first storage inner plate (312) is located inside the first storage outer plate (313); The first storage inner panel (312) has a first inner loading / unloading position (3122) corresponding to the transfer path (300), and the first storage outer panel (313) has a first outer loading / unloading position (3132) corresponding to the transfer path (300); The second reagent container storage mechanism (32) includes a second storage inner plate (322) and a second storage outer plate (323), the second storage inner plate (322) is located inside the second storage outer plate (323), the second storage inner plate (322) has a second inner access position (3222) corresponding to the transfer path (300), and the second storage outer plate (323) has a second outer access position (3232) corresponding to the transfer path (300), The reagent container temporary storage mechanism (51) includes a temporary storage inner board (512) and a temporary storage outer board (513), the temporary storage inner board (512) is located inside the temporary storage outer board (513), the temporary storage inner board (512) has a third inner loading / unloading position (5122) corresponding to the transfer path (300), and the temporary storage outer board (513) has a third outer loading / unloading position (5132) corresponding to the transfer path (300), The sample analysis device of claim 2, characterized in that the reagent container transfer mechanism (52) is used to transfer reagent containers (40) between the first inner loading / unloading position (3122) or the first outer loading / unloading position (3132) and the third inner loading / unloading position (5122) or the third outer loading / unloading position (5132), and / or is used to transfer reagent containers (40) between the second inner loading / unloading position (3222) or the second outer loading / unloading position (3232) and the third inner loading / unloading position (5122) or the third outer loading / unloading position (5132).
4. a connection between the first inner insertion / removal position (3122) and the first pivot center (315) and a connection between the first outer insertion / removal position (3132) and the first pivot center (315) form a first included angle (400); a connection between the second inner insertion / removal position (3222) and the second pivot center (325) and a connection between the second outer insertion / removal position (3232) and the second pivot center (325) form a second included angle (500); The sample analyzer of claim 3, characterized in that the connection between the third inner insertion / removal position (5122) and the third pivot center (515) and the connection between the third outer insertion / removal position (5132) and the third pivot center (515) form a third included angle (600).
5. The first storage inner plate (312) is configured to form a plurality of first inner mounting positions (3121) for supporting reagent containers (40) along the circumferential direction of the first rotation center (315), and the first storage inner plate (312) rotates so that the plurality of first inner mounting positions (3121) sequentially pass through the first inner loading / unloading position (3122); The first storage outer plate (313) is configured to form a plurality of first outer mounting positions (3131) for supporting reagent containers (40) along the circumferential direction of the first rotation center (315), and the first storage outer plate (313) rotates so that the plurality of first outer mounting positions (3131) sequentially pass through the first outer loading / unloading position (3132); The second storage inner plate (322) has a plurality of second inner mounting positions (3221) for supporting reagent containers (40) formed along the circumferential direction of the second rotation center (325), and the second storage inner plate (322) rotates so that the plurality of second inner mounting positions (3221) sequentially pass through the second inner loading / unloading position (3222); The second storage outer plate (323) is configured to form a plurality of second outer mounting positions (3231) for supporting a plurality of reagent containers (40) along the circumferential direction of the second rotation center (325), and the second storage outer plate (323) rotates so that the plurality of second outer mounting positions (3231) sequentially pass through the second outer loading / unloading position (3232); The temporary storage inner plate (512) is configured to form a plurality of third internal mounting positions (5121) for supporting reagent containers (40) along the circumferential direction of the third rotation center (515), and the temporary storage inner plate (512) rotates so that the plurality of third internal mounting positions (5121) sequentially pass through the third internal loading / unloading position (5122); The temporary storage outer plate (513) is configured to form a plurality of third outer mounting positions (5131) for supporting reagent containers (40) along the circumferential direction of the third rotation center (515), and the temporary storage outer plate (513) rotates so that the plurality of third outer mounting positions (5131) sequentially pass through the third outer loading / unloading position (5132), The sample analysis device of claim 3, wherein the reagent container transfer mechanism (52) is used to transfer a reagent container (40) between a first inner loading / unloading position (3122) or a first outer loading / unloading position (3132) and the third inner loading / unloading position (5122), or to transfer a reagent container (40) between the first inner loading / unloading position (3122) or the first outer loading / unloading position (3132) and the third outer loading / unloading position (5132), or to transfer a reagent container (40) between the second inner loading / unloading position (3222) or the second outer loading / unloading position (3232) and the third inner loading / unloading position (5122), or to transfer a reagent container (40) between the second inner loading / unloading position (3222) or the second outer loading / unloading position (3232) and the third outer loading / unloading position (5132).
6. The sample analysis device described in claim 2, characterized in that the third loading / unloading position (514) includes a third left loading / unloading position (5141) close to the first reagent container storage mechanism (31) and a third right loading / unloading position (5142) close to the second reagent container storage mechanism (32), and the reagent container transfer mechanism (52) transfers reagent containers (40) between the first loading / unloading position (314) and the third left loading / unloading position (5141), and between the second loading / unloading position (324) and the third right loading / unloading position (5142).
7. The sample analysis device of claim 2, wherein a vertical symmetry line (700) passing through the fourth pivot center (21) and perpendicular to the center line (200) is formed, and the third pivot center (515) is offset from the vertical symmetry line (700) and is close to the first reagent container storage mechanism (31) or the second reagent container storage mechanism (32).
8. The sample analyzer of claim 7, wherein the vertical symmetry line (700) and the foot of the center line (200) are located at the midpoint of the center line (200).
9. The reagent container transfer mechanism (52) an insertion / removal device (521) for inserting and removing a reagent container (40); a rotation drive device (522) for driving the rotation of the take-in / take-out device (521); an elevation drive device (523) for driving the loading / unloading device (521) to elevate and lower; a horizontal drive (524); The sample analyzer of claim 2, wherein the horizontal drive device (524) drives the loading / unloading device (521) to move along the transfer path (300) between the first loading / unloading position (314) and the third loading / unloading position (514), and between the second loading / unloading position (324) and the third loading / unloading position (514).
10. The sample analyzer of claim 9, wherein the insertion / removal device (521) is a clip, or the insertion / removal device (521) is a suction nozzle, and the suction nozzle is arranged off the rotation axis of the rotation drive device (522).
11. the first reagent container storage mechanism (31) is configured to form a plurality of first placement positions (311) for supporting reagent containers (40) along a circumferential direction of the first rotation center, and the first reagent container storage mechanism (31) rotates such that the plurality of first placement positions (311) sequentially pass through the first loading / unloading position (314); the second reagent container storage mechanism (32) is configured to form a plurality of second placement positions (321) for supporting reagent containers (40) along a circumferential direction of the second rotation center, and the second reagent container storage mechanism (32) rotates such that the plurality of second placement positions (321) sequentially pass through the second loading / unloading position (324); the reagent container temporary storage mechanism (51) is configured to form a plurality of third placement positions (511) for supporting the reagent containers (40) along a circumferential direction of the third rotation center, and the reagent container temporary storage mechanism (51) rotates such that the plurality of third placement positions (511) sequentially pass through the third loading / unloading position (514); 3. The sample analyzer of claim 2, wherein the reagent container transfer mechanism (52) is used to transfer a reagent container (40) between the first loading / unloading position (314) and the third loading / unloading position (514) or between the second loading / unloading position (324) and the third loading / unloading position (514).
12. A horizontal symmetry line (800) is formed that passes through the fourth pivot center (21) and is parallel to the center line (200), The sample analyzer further includes a sample transport mechanism (70) for transporting sample containers; 2. The sample analyzer of claim 1, wherein the centerline (200) and the sample transport mechanism (70) are located on opposite sides of the horizontal line of symmetry (800).
13. The sample analyzer of any one of claims 1 to 12, further comprising a collection box (60), wherein a collection port (61) of the collection box (60) is provided below the transfer path (300).
14. The sample analyzer of claim 13, wherein the recovery port (61) is located between the first reagent container storage mechanism (31) and the reagent container temporary storage mechanism (51), or the recovery port (61) is located between the second reagent container storage mechanism (32) and the reagent container temporary storage mechanism (51).
15. the reaction disk (20) can support a plurality of reaction vessels and includes a first reagent dispensing position (22), a second reagent dispensing position (23), a third reagent dispensing position (24), and a fourth reagent dispensing position (25); the first reagent container storage mechanism (31) includes a first reagent aspirating position (316) and a second reagent aspirating position (317); the second reagent container storage mechanism (32) includes a third reagent aspirating position (326) and a fourth reagent aspirating position (327); The sample analyzer further includes a first reagent injection mechanism (91) and a second reagent injection mechanism (92), The first reagent injection mechanism (91) includes a first reagent needle (911) and a second reagent needle that operate independently; the first reagent needle (911) is used to aspirate a reagent from within the reagent container (40) located at the first reagent aspirating position (316) and transfer and inject it along a first straight line (913) into a reaction container located at the first reagent discharging position (22); the second reagent needle is used to aspirate a reagent from the reagent container (40) located at the second reagent aspirating position (317) and transfer and inject it along a second straight line (914) into a reaction container located at the second reagent dispensing position (23); the second reagent injection mechanism (92) includes a third reagent needle and a fourth reagent needle that operate independently; the third reagent needle is used to aspirate a reagent from the reagent container (40) located at the third reagent aspirating position (326) and transfer and inject it along a third straight line (923) into a reaction container located at the third reagent dispensing position (24); A sample analyzer as described in any one of claims 1 to 12, characterized in that the fourth reagent needle is used to aspirate reagent from a reagent container (40) located at the fourth reagent aspirating position (327) and transfer and inject it along a fourth straight line (924) into a reaction container located at the fourth reagent dispensing position (25).
Citation Information
Patent Citations
Automatic analyzer
JP2004045112A
Automatic analyzer
JP2008203004A
Analytical apparatus
JP2009068992A
Analytical apparatus
JP2009068993A
Automatic analyzer, reagent replenishing apparatus and reagent auto-loading method
JP2010085249A
Cited By
Display device
CN121999683A