Port connectors

Abstract

To provide port connectors for sterilizing exposed surfaces of a fluid port of an article to be sterilized to a sterilization apparatus.SOLUTION: The port connector can include a housing that couples to a fluid port. The housing may define an inlet that fluidly couples to the fluid port, an outlet that fluidly couples to a sterilization apparatus, and a fluid passageway fluidly coupling the inlet and outlet. The port connector can include a porous member supported by the housing. The porous member has a porous structure defining a plurality of minute passageways. The porous member is arranged relative to the housing to engage the fluid port when the port connector is connected to the fluid port.SELECTED DRAWING: Figure 16

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Application No. 63 / 193,377, filed May 26, 2021, which is incorporated herein by reference in its entirety. [Technical Field]

[0002] FIELD OF THE DISCLOSURE The present disclosure relates generally to port connectors, and more particularly to port connectors for sterilizing the surface of a fluid port. [Background technology]

[0003] Certain articles, such as medical instruments (e.g., endoscopes), need to be sterilized between uses. These articles may contain internal lumens that require sterilization. One method of sterilizing these internal lumens is to transfer a sterilizing fluid or sterilant through the lumen. To transfer the sterilizing fluid through the lumen, a port connector is typically coupled to the article's fluid port.

[0004] For example, International Publication No. 2018 / 090133 describes a sterilization system that places an endoscope in a chamber having a port connector attached to a fluid port of the endoscope. The port connector fluidly couples the internal lumen of the endoscope to a pressure source (e.g., a negative pressure source). To sterilize the internal lumen of the endoscope, a sterilizing fluid (such as hydrogen peroxide vapor) is introduced into the chamber and then drawn through the internal lumen of the endoscope via the pressure source fluidly coupled to the endoscope by the port connector. Summary of the Invention

[0005] In one aspect, a port connector for connecting to a fluid port of a device to be sterilized with a sterilization apparatus is disclosed. The fluid port has a distal end defining a fluid port outlet. The fluid port defines a lumen extending proximally from the fluid port outlet. The port connector includes a housing configured to couple to the fluid port. The housing defines an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to the sterilization apparatus, and a fluid passage extending between and fluidly coupling the inlet and the outlet. A porous member is supported by the housing. The porous member has a porous structure defining a plurality of micropassages. The porous member is positioned relative to the housing to engage the distal end of the fluid port when the port connector is connected to the fluid port.

[0006] In another aspect, a method for sterilizing a device having a fluid port includes connecting a port connector to the fluid port. The port connector defines an inlet in fluid communication with the fluid port, an outlet, and a fluid passageway extending between the inlet and the outlet to fluidly connect the inlet and the outlet. The port connector has a porous member that engages with an end of the fluid port. The method includes fluidly connecting a sterilization device to the outlet of the port connector and sterilizing the end of the fluid port by moving a sterilizing fluid through the porous member while the port connector is connected to the fluid port.

[0007] In another aspect, a port connector for connecting a fluid port of a device to be sterilized to a sterilizer includes a housing configured to mate with the fluid port, the housing defining an outlet configured to be fluidly coupled to the sterilizer, a seal positioned to form a fluid tight seal with the fluid port, and a piston supported by the housing and movable relative to the housing upon application of a pressure differential by the sterilizer.

[0008] In another aspect, a port connector for connecting to a fluid port of a device to be sterilized to a sterilization apparatus includes a porous member having a porous structure defining a plurality of micropassages, the fluid port defining a lumen. The porous member defines at least a portion of a receiving chamber sized and shaped to receive the fluid port. The inner surface is positioned to engage the fluid port when the fluid port is positioned within the receiving chamber. A housing is coupled to the porous member. The housing defines an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to the sterilization apparatus, and a fluid passage extending between and fluidly coupling the inlet and the outlet. The inlet is positioned in the at least a portion of the receiving chamber defined by the inner surface of the porous member.

[0009] Other objects and features of the present disclosure will be in part apparent and in part pointed out hereinafter. [Brief explanation of the drawings]

[0010] [Figure 1] FIG. 1 is a perspective view of a port connector according to one embodiment of the present disclosure connected to a fluid port. [Figure 2] FIG. 2 is a longitudinal cross-sectional view of a port connector. [Figure 3] FIG. 3 is a partially enlarged view of FIG. 2. [Figure 4] FIG. 2 is a perspective view of the port connector of FIG. 1. [Figure 5] FIG. 2 is an exploded view of the port connector of FIG. 1. [Figure 6] 2 is a cross-sectional view of a gasket of the port connector of FIG. 1. [Figure 7] FIG. 10 is a perspective view of a port connector according to another embodiment of the present disclosure connected to a fluid port. [Figure 8] FIG. 2 is a longitudinal cross-sectional view of a port connector. [Figure 8A] 8 is a longitudinal cross-sectional view of another embodiment of a port connector similar to the port connector of FIG. 7. [Figure 9]8, showing the gasket of the port connector in an initial position. [Figure 10] 8, showing the gasket in a sealing position. FIG. [Figure 11] FIG. 8 is a perspective view of the port connector of FIG. 7. [Figure 12] FIG. 8 is an exploded view of the port connector of FIG. 7. [Figure 13] FIG. 8 is a perspective view of a slide of the port connector of FIG. 7. [Figure 14] FIG. 8 is a perspective view of a plunger of the port connector of FIG. 7. [Figure 15] FIG. 10 is a perspective view of a port connector according to another embodiment of the present disclosure. [Figure 16] FIG. 17 is a perspective view of the port connector of FIG. 16 connected to a fluid port. [Figure 17] FIG. 2 is a longitudinal cross-sectional view of a port connector. [Figure 17A] FIG. 18 is a partially enlarged view of FIG. [Figure 18] FIG. 10 is a perspective view of a port connector according to another embodiment of the present disclosure connected to a fluid port. [Figure 19] 1 is a longitudinal cross-sectional view of a port connector in an initial position over a fluid port. FIG. [Figure 20] FIG. 20 is a partially enlarged view of FIG. 19. [Figure 21] 19 is a longitudinal cross-sectional view of FIG. 18 with the port connector in a second position on the fluid port. [Figure 22] FIG. 22 is a partially enlarged view of FIG. 21. [Figure 23] FIG. 20 is a perspective view of the plunger of the port connector of FIG. 18. [Figure 24] FIG. 10 is a perspective view of a port connector according to another embodiment of the present disclosure. [Figure 25] FIG. 25 is a perspective view of the port connector of FIG. 24 connected to a fluid port. [Figure 26] FIG. 26 is a longitudinal cross-sectional view of FIG. 25. [Figure 27]FIG. 25 is a cross-sectional view of FIG. 24 with the porous member removed to reveal internal details.

[0011] Corresponding reference characters indicate corresponding parts throughout the drawings. DETAILED DESCRIPTION OF THE INVENTION

[0012] The port connectors disclosed herein can be used with the sterilization systems and methods described in WO 2018 / 090133. The port connectors described herein allow the fluid port itself to be sterilized even when the port connector is attached. The port connectors allow sterile fluid to contact the interior and / or exterior surfaces of the fluid port that would be blocked or covered using a conventional port connector, thus generally allowing the entire fluid port to be sterilized; more specifically, the exterior or exposed surfaces are closest to the lumen of the fluid port because these surfaces are most likely to come into contact with fluid flowing through the fluid port. The port connectors disclosed herein may be referred to as leaky connectors because the port connectors may not form a fluid-tight seal with the fluid port and / or may form a fluid-tight seal with the fluid port only under certain conditions.

[0013] 1-6, one embodiment of a port connector according to the present disclosure is generally designated by the reference numeral 100. The port connector 100 is shown attached to a fluid port 10 of an article (not shown), such as an endoscope. The illustrated fluid port 10 is a male fluid port having one or more external circumferential barbs to facilitate connection and sealing of components and devices (such as tubing) to the fluid port, as is commonly known in the art. As shown in FIGS. 2 and 3, the fluid port defines a fluid port outlet 16 at its end (e.g., the distal or free end) and a lumen 12 extending proximally from the fluid port outlet. The fluid port 10 has a distal end face 14 (broadly, the outer surface) at its end. The distal end face 14 faces distally and is adjacent to the fluid port outlet 16. Other configurations of fluid ports are within the scope of the present disclosure. The port connector 100 is used to connect the fluid port 10 of an article or device to be sterilized (by a sterilizing fluid) to a pressure source (e.g., a negative pressure source and / or a positive pressure source) of a sterilization system or apparatus (not shown), such as the sterilization system described in WO 2018 / 090133. In one embodiment, the pressure source is a negative pressure source that creates a pressure differential to draw fluid (e.g., sterilizing fluid) from the environment surrounding the article and port connector 100 through the fluid port 10 and port connector and into the article's internal lumen to sterilize the article's internal surface (e.g., internal lumen). The negative pressure source can be any suitable pressure source, such as a vacuum, a pump, or a chamber that has a lower pressure than the environment surrounding the article.

[0014] The port connector 100 includes a housing 102. The housing 102 has a proximal end and a distal end. The proximal end defines an inlet 104 ( FIG. 3 ) configured to be fluidly coupled to the fluid port (e.g., the inlet is disposed in fluid communication with the fluid port). In the illustrated embodiment, the proximal end includes an insert 103 sized and configured to be inserted into the lumen 12 of the fluid port 10 through the fluid port outlet 16 such that the inlet 104 is disposed within the lumen. The insert 103 defines the inlet 104. Preferably, the insert 103 does not engage the fluid port 10. The distal end (e.g., the distal port) defines an outlet 106 configured to be fluidly coupled to a negative pressure source (broadly, a sterilizer). In other words, the outlet 106 is disposed in fluid communication with the negative pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet 106 to the negative pressure source. The distal end includes a barbed tube port fitting. The housing 102 defines a fluid passageway 108 (e.g., lumen, bore) extending between the inlet 104 and the outlet 106 to fluidly couple the inlet 104 and the outlet 106 (e.g., providing fluid communication between the inlet 104 and the outlet 106).

[0015] The housing 102 is configured to be coupled to the fluid port 10. The housing 102 includes a coupler 110 configured to couple to (e.g., attach to) the fluid port 10. In the illustrated embodiment, the coupler 110 includes first and second resiliently deflectable clips 112. The first and second clips 112 are configured to engage with the fluid port 10 to couple (e.g., secure) the port connector 100 to the fluid port. Each clip 112 includes a retainer 114 configured to engage with the fluid port 10 to secure the port connector 100 to the fluid port. The retainers 114 engage with barbs on the fluid port 10 to secure the coupler 110 to the fluid port. The clips 112 are disposed on opposite sides of the housing 102 and engage opposite sides of the fluid port 10. The housing 102 includes a living hinge 116 connecting each clip 112 to the remainder of the housing (e.g., the central body). The living hinges 116 allow each clip 112 to resiliently flex so that the coupler can be attached to and detached from the fluid port. The living hinges 116 bias the retainers 114 toward each other to prevent the port connector 100 from unintentionally detaching from the fluid port 10. Each clip 112 includes a finger tab 118 configured to be engaged by a user to flex the clip or rotate it about the living hinge 116. Other configurations of the coupler are within the scope of this disclosure. The housing 102 can also include one or more port guides 120 configured to engage with the fluid port 10 to help center the port connector 100 on the fluid port. In the illustrated embodiment, the housing 102 includes two port guides 120 positioned between the two clips 112 on either side of the housing 102 to engage with either side of the fluid port 10. Opposing inner surfaces of the port guides 120 can engage with the fluid port 10 to facilitate positioning the port connector 100 on the fluid port 10. The housing 102 may be a unitary piece or may be multiple pieces secured together. The guide 120 and / or clip 112 (broadly, the port connector 100) define a space sized and configured to receive the end of the fluid port 10.

[0016] 3, 5, and 6, the port connector 100 includes a seal or gasket 122 (broadly, a fluid port interface member). The gasket 122 is supported by (e.g., connected to) the housing 102. As shown in FIG. 3, the gasket 122 is supported by the housing 102 such that the gasket is partially spaced from the fluid port 10 when the housing is coupled to the fluid port. Specifically, the gasket 122 is positioned to face and be adjacent to the distal end face 14 of the fluid port 10 when the port connector 100 is attached to the fluid port. The guide 120 can also function as a stopper that engages with the fluid port 10 to position the gasket 122 adjacent to the distal end face 14 (e.g., in a longitudinal or proximal position). When the port connector 100 is attached to the fluid port 10, the port connector 100 (e.g., the gasket 122) does not form a fluid-tight seal with the fluid port. This allows sterilizing fluid in the environment surrounding the fluid port 10 of the article to contact and sterilize surfaces of the fluid port (e.g., end face 14) that would otherwise be blocked or covered when the port connector 100 engages with the fluid port to form a fluid-tight seal.

[0017] The port connector 100 forms a fluid-tight seal with the fluid port 10 when negative pressure (i.e., a negative pressure differential) is applied to the lumen 12 of the fluid port via a negative pressure source. This causes fluid (e.g., a sterilizing fluid) to be drawn through the fluid port 10 and into the internal lumen of the article to sterilize the article. The gasket 122 is configured to move toward and engage with the fluid port 10 upon application of negative pressure from the negative pressure source to form a fluid-tight seal in order to draw fluid through the fluid port. As used herein, the term "fluid-tight seal" refers to a seal that provides a sufficient obstruction to fluid flow such that fluid flows from another area (e.g., to the end of the internal lumen of the article opposite the fluid port) as a result of a pressure differential, but does not require an absolute fluid-tight seal such that fluid cannot pass through. For example, the fluid-tight seal between the gasket 122 and the fluid port 10 must create a sufficient obstruction to fluid flow between the gasket 122 and the fluid port 10 such that fluid is drawn into the article's internal lumen(s) and through the lumen(s) via the fluid port into the port connector 100. In operation, preferably, the gasket 122 forms an absolute fluid-tight seal with the fluid port 10 such that fluid cannot pass between the gasket 122 and the fluid port 10, although such absolute fluid-tightness is not necessary for the operation of the port connector 100. As used herein, the phrase "negative pressure" means a pressure lower than the pressure of the environment surrounding the relative component to which the negative pressure is being applied, such as the port connector 100. For example, applying a negative pressure from a negative pressure source to the port connector 100 means that the negative pressure source applies a pressure to the port connector that is lower than the pressure of the environment surrounding the port connector (e.g., a chamber of a sterilization system in which the port connector is located). In other words, the negative pressure creates a negative pressure difference between the environment surrounding the relative components and the negative pressure source, thereby causing fluid to flow from the environment toward the negative pressure source. The negative pressure can be a pressure above atmospheric pressure or a pressure below atmospheric pressure (vacuum). In certain preferred embodiments, the negative pressure is less than atmospheric pressure (vacuum).

[0018] In the illustrated embodiment, the gasket 122 includes a flange 124. The flange 124 is bendable (e.g., elastically bendable). The flange 124 is ring-shaped. The flange 124 is configured to move toward and engage with the fluid port 10 (e.g., end face 14) upon application of negative pressure (as shown by the arrow in FIG. 3 ) to form a fluid-tight seal with the fluid port. The flange 124 is disposed adjacent to the end face 14 of the fluid port 10 when the port connector 100 is attached to the fluid port. For example, the flange 124 may only be spaced from the end face 14 by a few millimeters. As a result, when negative pressure is applied by a negative pressure source, the negative pressure (e.g., a sufficient pressure differential across the flange 124) causes the flange to bend and engage with the end face of the fluid port 10 to form a fluid-tight seal. In one embodiment, the pressure differential between the negative pressure source and the environment surrounding the article may be a ratio of about 1 / 100, although other differences are within the scope of this disclosure. The flange 124 preferably extends radially outward from the portion of the housing 102 adjacent the flange such that the radially outer portion (e.g., the distal face) of the flange is exposed to the environment to increase the effect of the pressure differential on the flange. The flange 124 may include a bent section 126 where the majority of the flange's flexing occurs. In the illustrated embodiment, the bent section is adjacent the radially inner edge of the flange 124 and has a thickness that is less than the thickness of the more radially outer portion of the flange. Thus, a weak point in the flange 124 is formed around which the flange can flex. The flange 124 is elastically deformable such that the flange 124 returns to its undeformed or unflexed state as the pressure differential approaches (or reaches) equilibrium, as shown in FIG. 3 . For example, the flange 124 may be designed to return to its unflexed state when the pressure differential is approximately half the pressure differential initially applied by the negative pressure source. Thus, the flange 124 can be configured to disengage from the fluid port 10 and break the fluid-tight seal over a specific pressure differential or range of pressure differentials.

[0019] In operation, the port connector 100 is connected to a fluid port 10 to sterilize an article having the fluid port 10. As previously described, the gasket 122 is spaced from the fluid port 100 when the port connector is initially connected to the fluid port 10 (e.g., before a fluid-tight seal is formed). A negative pressure source is fluidly connected to the port connector 100 (e.g., outlet 106). The article with the fluid port 10 is placed in a chamber (e.g., a wash chamber). A fluid (e.g., a sterilizing fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced around the chamber, contacting and sterilizing surfaces of the article and the fluid port, such as surfaces that are blocked or covered when the port connector 10 forms a fluid-tight seal with the fluid port. An operator then applies negative pressure via the negative pressure source. As a result, a fluid-tight seal is formed between the port connector 100 and the fluid port 10 (e.g., end face 14) by moving the gasket 122 (e.g., flange 124) toward and into engagement with the fluid port. As previously described, the fluid-tight seal is formed by flexing the flange 124. Furthermore, the application of negative pressure moves (e.g., draws) fluid into and through the interior lumen of the article, through the fluid port 10 and port connector 100, thereby sterilizing the interior of the article. Thus, even if the port connector 100 is attached to the fluid port 10 during the sterilization process, the entire fluid port will generally be exposed to sterilizing fluid at some point and sterilized.

[0020] 7-14, another embodiment of a port connector according to the present disclosure is generally designated by the reference numeral 200. The port connector 200 of FIGS. 7-14 is generally similar to the port connector 100 of FIGS. 1-6, and therefore, for ease of understanding, the higher reference numeral "100" is used where like, similar, or identical parts are used. Therefore, unless otherwise stated or indicated, the above description regarding the port connector 100 of FIGS. 1-6 also applies to the port connector 200 of FIGS. 7-14.

[0021] In this embodiment, the housing 202 includes a piston or plunger 230, a connector body 232, a sleeve or slide 234, and a cap 236. The cap 236 defines the outlet 206 and is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet to a negative pressure source. The plunger 230 defines the insert 203 and the inlet 204. The gasket 222 is supported by the plunger 230. The connector body 232 defines a longitudinal bore 238 extending therethrough. The plunger 230 is movably (e.g., slidably) disposed within the longitudinal bore 238. The port connector 200 may include a seal 240, such as an O-ring, disposed between the plunger 230 and the connector body 232 to prevent fluid flow between the plunger and the connector body. In the illustrated embodiment, the seal 240 can also function as a stop with which the plunger 230 engages to limit distal movement of the plunger relative to the connector body 232. The slide 234 is movably (e.g., slidably) supported by (e.g., attached to) the connector body 232. The slide 234 has a peripheral wall 242 that surrounds and moves relative to a cylindrical portion of the connector body 232. The peripheral wall 242 thus defines a cavity sized and shaped to receive the distal end of the connector body 232. The port connector 200 can include one or more seals 244, such as O-rings, disposed between the slide 234 (e.g., peripheral wall 242) and the connector body 232 (e.g., cylindrical portion) to prevent fluid flow between the slide and the connector body. One or both of the slide 234 and the connector body 232 can define a groove sized and shaped to receive a portion of the seal 240. In the illustrated embodiment, the connector body 232 defines the groove. Cap 236 is secured to slide 234 (e.g., at the distal end of the slide). Slide 234 and plunger 230 are operatively coupled to one another such that movement of the slide results in movement of the plunger. In the illustrated embodiment, plunger 230 is secured directly to slide 234.The slide 234 defines a plunger recess 258 (FIG. 13) that is sized and shaped to receive the distal end of the plunger 230 .

[0022] The plunger 230, the connector body 232, the slide 234, and the cap 236 define the fluid passageway 208. That is, the plunger 230, the connector body 232, the slide 234, and the cap 236 each define a portion of the fluid passageway 208. Referring to FIG. 9 , the portion of the fluid passageway 208 defined by the plunger 230 includes one or more plunger openings 246 and a plunger passageway (e.g., an elongated bore) 248. The plunger passageway 248 extends between the inlet 204 and the plunger openings 246 and fluidly couples the inlet 204 to the plunger openings 246. In the illustrated embodiment, the plunger 230 defines two plunger openings 246, one on each side of the plunger. The fluid passageway 208 includes a fluid chamber 250 defined by the housing 202. The one or more plunger openings 246 are in fluid communication (e.g., direct fluid communication) with the fluid chamber 250. As described in more detail below, the fluid chamber 250 is configured to substantially collapse or reduce in volume due to the application of a negative pressure (i.e., a negative pressure differential). The fluid chamber 250 is at least partially defined by the connector body 232 and the slide 234. Specifically, the fluid chamber 250 is bounded by the distal end of the connector body 232, the plunger 230, the peripheral wall 242, and the separation wall 252 of the slide 234. The portion of the fluid passageway 208 defined by the slide 234 includes at least one slide passageway 254 ( FIG. 13 ). The slide passageway 254 fluidly couples the fluid chamber 250 to the outlet 206. In the illustrated embodiment, the slide 234 includes four slide passageways 254. The slide 234 and the cap 236 define an outlet chamber 256 ( FIG. 8 ) that is fluidly coupled to the outlet 206. A slide passage 254 extends between and fluidly connects the outlet chamber 256 and the fluid chamber 250 on either side of the separation wall 252 .

[0023] The plunger 230 is configured to move along the longitudinal bore 238 toward or proximally to the fluid port 10 upon application of a pressure differential (i.e., negative pressure), moving the gasket 222 toward the fluid port 10 (e.g., end face 14) so ​​that the gasket engages the fluid port and forms a fluid-tight seal therewith. Specifically, the slide 234 moves proximally relative to the connector body 232 due to application of negative pressure from the negative pressure source, substantially reducing (e.g., collapsing) the volume of the fluid chamber 250 ( FIG. 10 ). As a result of the proximal movement of the slide 234, the plunger 230 moves proximally (from the initial position shown in FIG. 9 ) to move the gasket toward the fluid port 10 (e.g., end face 14) so ​​that the gasket engages the fluid port 10 and forms a fluid-tight seal therewith. FIG. 10 shows the gasket 222 in a sealing position, forming a fluid-tight seal with the fluid port 10 after application of negative pressure. Preferably, the gasket 22 forms an absolute fluid-tight seal with the fluid port 100. To facilitate collapse of the fluid chamber 250, the combined cross-sectional area of ​​the one or more slide passages 254 is larger than the combined cross-sectional area of ​​the plunger opening 246. With this configuration, the plunger opening 246 creates a restriction to fluid flow (relative to the slide passage 254), thereby facilitating the creation of a local negative pressure within the fluid chamber 250 sufficient to move the slide 234 proximally. Preferably, the plunger opening 246 is configured such that the plunger opening remains in fluid communication with the fluid chamber 250 when the plunger is moved proximally. In the illustrated embodiment, the distal end of the connector body 232 also includes a chamfer or bevel 260 at the distal end of the longitudinal bore 238 to maintain the plunger opening 246 in fluid communication with the fluid chamber 250 when the plunger is moved proximally (e.g., in the sealed position).

[0024] In the illustrated embodiment, the resilience (e.g., flexibility) of the gasket 222, the weight of the slide 234 and cap 236, and the weight of the fluid conduit attached to the cap 236 generally maintain the slide and plunger 230 in an initial position ( FIG. 9 ) prior to application of negative pressure when the coupler 210 (e.g., clip 212, port guide 220) is attached to the fluid port 10. In one embodiment, the port connector 200 can include a spring (e.g., a coil spring) that can bias the slide 234 and plunger 230 distally in the initial position.

[0025] 14 , the plunger 230 is generally cylindrical. The plunger 230 defines a groove 262 in which the gasket 222 is disposed. The groove 262 is defined distally by a radial or circumferential flange 264. The flange 264 supports the gasket 222 when the gasket engages with the fluid port 10. The flange 264 is also positioned to engage the connector body 232, and more specifically, the seal 240, to limit distal movement of the plunger 230 (e.g., to position the plunger and slide 234 in an initial position).

[0026] Referring to FIG. 8A, a version of the port connector without seals 240, 244 is generally designated by the reference numeral 200′. Port connector 200′ of FIG. 8A is similar to port connector 200 of FIG. 8, and like, similar, or identical elements are designated with the same reference numerals followed by a prime. In this embodiment, the clearance between the outer surface of connector body 232′ and the inner surface of slide 234′ is very small, thereby creating an ultra-low leakage, low-friction interface between the connector body and the slide that allows the slide to move relative to the connector body. Similarly, the clearance between the inner surface of connector body 232′, which defines longitudinal bore 238′, and the outer surface of plunger 230′ is also very small, again creating an ultra-low leakage, low-friction interface between the connector body and the plunger that allows the plunger to move relative to the connector body. The low-leakage interfaces between these components are sufficient to provide a sufficiently large resistance to fluid flow between them so that when negative pressure is applied to the port connector 200', the slide 234' and plunger 230' move proximally to a sealing position, drawing fluid through the fluid port 10 as described herein in connection with the port connector 200 of FIG. 8. This occurs despite fluid that may flow along these low-leakage interfaces. Thus, the port connector 200' of FIG. 8A generally functions and operates similarly to the port connector 200 of FIG. 8.

[0027] In operation, the port connector 200 is connected to a fluid port 10 to sterilize an article having the fluid port 10. As previously described, the gasket 222 is spaced from the fluid port 10 when the port connector 200 is initially connected to the fluid port (e.g., before a fluid-tight seal is formed). A negative pressure source is fluidly connected to the port connector 200 (e.g., outlet 206). The article with the fluid port 10 is placed in a chamber (e.g., a wash chamber). A fluid (e.g., a sterilizing fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before negative pressure is applied. During this time, the fluid can move naturally or be forced around the chamber, contacting and sterilizing surfaces of the article and the fluid port, such as surfaces that are blocked or covered when the port connector 10 forms a fluid-tight seal with the fluid port. An operator then applies negative pressure via the negative pressure source. As a result, a fluid-tight seal is formed between the port connector 200 and the fluid port 10 (e.g., end face 14) by moving the gasket 222 toward and into engagement with the fluid port when connected to the fluid port by each clip 212 (e.g., retainer 214). As previously described, moving the gasket 222 includes moving the plunger 230 and slide 234. Specifically, application of negative pressure creates a vacuum within the fluid chamber 250 that moves the slide 234 proximally relative to the connector body 232. Furthermore, application of negative pressure moves (e.g., draws) fluid through the fluid port 10 and port connector 200 into the interior lumen of the article, thereby sterilizing the interior of the article.

[0028] 15-17, another embodiment of a port connector according to the present disclosure is generally designated by the reference numeral 300. The port connector 300 of FIGS. 15-17 is generally similar to the port connector 100 of FIGS. 1-6, and therefore, for ease of understanding, the higher reference numeral "200" is used where like, similar, or identical parts are used. Therefore, unless otherwise stated or indicated, the above description regarding the port connector 100 of FIGS. 1-6 also applies to the port connector 300 of FIGS. 15-17.

[0029] The port connector 300 of this embodiment includes a porous member 322 (broadly speaking, a fluid port interface member). The porous member 322 is supported by the housing 302. In the illustrated embodiment, the porous member 322 is attached to the insert 303. As shown in FIG. 17 , the porous member 322 is positioned relative to the housing 302 so as to engage with the fluid port 10 when the port connector 300 is connected to the fluid port. Specifically, the porous member 322 is positioned to engage with the distal end (specifically, the distal end surface 14) of the fluid port 10. The porous member 322 has a porous structure that defines a plurality of randomly arranged interconnected interstitial spaces, and the interstitial spaces form a plurality of micropassages 321 that penetrate and / or are within the porous member. The porous member 322 is positioned to face and engage with the distal end surface 14 of the fluid port 10 when the port connector 300 is attached to the fluid port. The porous member 322 is positioned relative to the housing 302 such that when the port connector is connected to the fluid port 10, at least a portion of the micropassages fluidly couple the fluid port outlet 16 to an environment external to the port connector 300. Thus, when the port connector 300 is attached to the fluid port 10, the porous member 322 does not form an absolute fluid-tight seal with the fluid port. Instead, fluid can migrate through the porous member 322 via the micropassages 321. However, as explained in more detail below, the port connector 300 can still be considered to form a fluid-tight seal (as defined herein) with the fluid port because the porous member 322 sufficiently impedes fluid flow through the fluid port 10 such that fluid flows from other areas (e.g., to the end of the article's internal lumen opposite the fluid port) as a result of a pressure differential.

[0030] The porous member is preferably made of a biocompatible, hydrophobic, and / or non-flammable material. In one embodiment, the porous member is formed from expanded polytetrafluoroethylene (ePTFE), such as FluroFlex® ePTFE, although other suitable materials are within the scope of this disclosure. In one embodiment, the porous member has a density of about 0.3-0.6 g / cm 3or more preferably within the inclusive range of about 0.4 to 0.5 g / cm 3 The density may be in the inclusive range of

[0031] In one embodiment, as shown, the micropassages 321 of the porous member 322 are arranged substantially randomly throughout the porous member. In one embodiment, a porosity control material or coating 325 (FIG. 17A) is applied to the porous member 322. For example, the porosity control material 325 may be applied to one or more surfaces (e.g., the outer surface) of the porous member 322. The porosity control material 325 may be applied to the entire surface of the porous member 322, or to only a portion of the surface. The porous member 322 may be interlocked or coated with the porosity control material 325. By applying the porosity control material 325 to one or more surfaces of the porous member 322, a flow path can be defined through the porous member rather than relying on the randomness of the micropassages 321. The porosity control material 325 at least partially blocks at least some of the micropassages 321 of the porous member 322 to control how and where the sterilizing fluid flows through the porous member. The porosity control material 325 may completely block the micropassage 321 or may only partially block (e.g., cover) the micropassage with which it is aligned. The porosity control material 325 may also increase the resistance to sterilizing fluid flow through the porous member 322 so that an appropriate amount of sterilizing fluid is also drawn through the article. Preferably, the resistance to sterilizing fluid flow through the article and the porous member 322 is relatively similar so that sterilizing fluid is drawn through both the porous member and the article when a pressure differential is applied by the sterilization device. By applying the porosity control material 325 to the porous member 322, a fluid path (via the micropassage 321) through the porous member closest to or in contact with the fluid port 10 (e.g., the surface of the fluid port) can be more easily defined, thereby more reliably ensuring that the sterilizing fluid contacts the fluid port as it flows through the porous member. For example, in one embodiment, the porosity control material 325 is spaced from the portion of the porous member that contacts the fluid port 10. The porosity control material 325 may be non-porous or may have a porosity that is less than the porosity of the porous member 322. The porosity control material 325 may be made of any suitable material, such as polytetrafluoroethylene (PTFE).

[0032] 17 , the porous member 322 is positioned relative to the housing 302 such that when the port connector 300 is connected to the fluid port 10, the porous member covers a portion (broadly, at least a portion) of the fluid port outlet 16. The porous member 322 includes an engagement surface 323 that is positioned to engage with the distal end (e.g., distal end face 14) of the fluid port 10. The engagement surface 323 generally faces proximally. In the illustrated embodiment, the engagement surface 323 has a generally annular shape to match the generally annular end of the fluid port. The inner diameter ID ( FIG. 17A ) of the engagement surface 323 is smaller than the diameter D of the fluid port outlet 16. Similarly, the engagement surface 323 has an outer diameter OD ( FIG. 17A ) that is larger than the diameter D of the fluid port outlet 16. In one embodiment, the porous member 322 has a generally donut shape.

[0033] The porous member 322 allows sterilizing fluid in the environment surrounding the article's fluid port 10 to contact and sterilize a surface of the fluid port (e.g., end face 14). When a negative pressure differential force is applied to the port connector 300 via a negative pressure source, the sterilizing fluid moves (e.g., is drawn) through the porous member 322 (specifically, through at least some of the micropassages 321). Some of these micropassages 321 lead to and / or along the portion of the fluid port 10 (e.g., end face 14) with which the porous member 322 is engaged. As a result, as the sterilizing fluid passes through the porous member 322, the sterilizing fluid contacts the fluid port 10, such as the end face 14, thereby sterilizing the portion of the fluid port with which the porous member is engaged.

[0034] In this embodiment, the housing 302 includes a plurality of port guides 320 configured to engage with the fluid port 10 to align the porous member 322 with the end of the fluid port. In the illustrated embodiment, the housing 302 includes six port guides 320, three of which are located on one side of the housing and three of which are located on the opposite side of the housing. Each port guide 320 includes a fin or flange including an inner edge that engages with the fluid port 10 to facilitate positioning the port connector 300 on the fluid port 10. The inner edge of each port guide 320 is contoured or shaped to match the external shape of the fluid port 10. The port guides 320 also function as stops to position the port connector 300 relative to the fluid port 10 (e.g., position it longitudinally or proximally).

[0035] In operation, to sterilize an article having a fluid port 10, the port connector 300 is connected to the fluid port. As previously described, the porous member 322 engages the end (e.g., distal end face 14) of the fluid port 10. A negative pressure source of a sterilization device is fluidly connected to the port connector 300 (e.g., outlet 306). The article with the fluid port 10 is placed in a chamber (e.g., a washing chamber). A fluid (e.g., a sterilizing fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before applying negative pressure. During this time, the fluid can move naturally or be forced around the chamber, contacting and sterilizing surfaces of the article and the fluid port, such as exposed surfaces. The fluid can also move into and through the porous member 322. The operator then applies a pressure differential (e.g., a negative pressure differential) via the negative pressure source. As a result, the negative pressure differential moves (e.g., draws) sterilizing fluid from the chamber through the porous member and into the lumen 12 of the fluid port 12. As the sterilizing fluid moves through the micropassages 321 of the porous member 322, it contacts the distal end surface 14 (and other surfaces engaged by the porous member), thereby sterilizing the distal end surface of the fluid port 10. Furthermore, the negative pressure differential moves (e.g., draws) sterilizing fluid into the internal lumen of the article, through the internal lumen, and through the fluid port 10 and port connector 100, thereby sterilizing the interior of the article. The movement of sterilizing fluid through the article and porous member 322 generally occurs simultaneously. The sterilizing fluid drawn through the article and porous member 322 is then drawn through the port connector 300 and moves toward the negative pressure source. Thus, even if the port connector 300 is attached to the fluid port 10 during the sterilization process, the entire fluid port is generally exposed to the sterilizing fluid and sterilized.

[0036] 18-23, another embodiment of a port connector according to the present disclosure is generally designated by the reference numeral 600. The port connector 600 is shown attached to a fluid port 20 of an article (not shown), such as an endoscope. Other configurations of the fluid port are within the scope of the present disclosure. The port connector 600 is used to connect the fluid port 20 of an article or device to be sterilized (by a sterilizing fluid) to a pressure source (e.g., a negative pressure source and / or a positive pressure source) of a sterilization system or apparatus (not shown), such as the sterilization system described in WO 2018 / 090133. The pressure source creates a pressure differential to move fluid (e.g., sterilizing fluid) from the environment surrounding the article through the fluid port 20 and the port connector 600 into the internal lumen of the article to sterilize the internal surface (e.g., internal lumen) of the article. The pressure source can be any suitable pressure source, such as a vacuum, a pump, or a chamber having a pressure lower or higher than the environment surrounding the article.

[0037] The port connector 600 includes a housing 602. The housing 602 has a proximal end and a distal end. The proximal end defines an inlet 604 configured to be fluidly coupled to a fluid port. The inlet 604 is sized and shaped to receive at least a portion (e.g., a distal portion) of the fluid port 20. In the illustrated embodiment, the inlet 604 is an elongated bore. Preferably, the portion of the housing 602 defining the inlet 604 does not engage the fluid port 20. The distal end (e.g., the distal port) defines an outlet 606 configured to be fluidly coupled to a pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tube to fluidly couple the outlet 606 to the pressure source. The inlet 604 and the outlet 606 are fluidly coupled to one another. The housing 602 defines a fluid passageway 608 extending between and fluidly coupling the inlet 604 and the outlet 606. The housing 602 is configured to be coupled to the fluid port 20. In the illustrated embodiment, the housing 602 is made of multiple components secured together. The housing 602 can be made of any suitable material, such as plastic (e.g., polypropylene).

[0038] The port connector 600 includes a seal or gasket 610 (broadly, a fluid port interface member). The seal 610 is supported by (e.g., connected to) the housing 602. In particular, the seal 610 is disposed along the inlet 604. The seal 610 is configured to engage with the fluid port 20. As described in more detail below, the seal 610 is configured to move from a first location or position on the fluid port 20 to a second location or position on the fluid port. The seal 610 engages with the fluid port 20 to prevent fluid flow between the seal and the fluid port. Preferably, the seal 610 forms an absolute fluid-tight seal with the fluid port 20. In the illustrated embodiment, the seal 610 is an O-ring. The housing 602 includes a groove 612 (e.g., a circumferential groove) in which the seal 610 is disposed. The seal 610 extends inward (e.g., radially inward) from an inner surface defining the inlet 610 to engage the fluid port 20. The seal 610 may be made of any suitable material, such as a thermoplastic elastomer (TPE) (eg, styrene-ethylene-butylene-styrene (SEBS)).

[0039] The port connector 600 includes a piston or plunger 614. The plunger 614 is movably (e.g., slidably) disposed within the housing 602. The plunger 614 is disposed within the fluid passageway 608. The plunger 614 includes a flange 618 and a shaft 616 extending proximally from the flange. The flange 618 has a generally conical shape. The flange 618 tapers outward (e.g., radially outward) as the flange extends distally from the shaft 616. The outer edge of the flange 618 (broadly, the plunger 614) includes one or more slots 620. The slots 620 are configured to allow fluid flow around the plunger 614. As described in more detail below, the slots 620 allow fluid flow from the inlet 604 to the outlet 606. The plunger 614 can be made of any suitable material, such as plastic (e.g., polyethylene, polypropylene, polytetrafluoroethylene).

[0040] The plunger 614 is configured to move within the housing 602 from an initial position ( FIGS. 19 and 20 ) to a second position ( FIGS. 21 and 22 ). The plunger 614 moves proximally from the initial position to the second position or toward the fluid port (and distally from the second position to the initial position). In the initial position, the plunger 614 (and housing 602) is configured to allow fluid to flow between the inlet 604 and the outlet 606. As shown in FIG. 20 , the housing 602 defines a plunger recess 622. When the plunger 614 is in the initial position, an outer edge of the flange 618 is aligned (e.g., laterally aligned) with the plunger recess 622. In some embodiments, the plunger recess 622 may be sized and configured to receive the outer edge of the flange 618. The plunger recess 622 provides clearance between the outer edge of the flange 618 and the inner surface of the housing 602, allowing fluid to flow around the plunger (e.g., flange) through the plunger recess 622 and slot 620 toward the outlet 606. In the illustrated embodiment, the flange 618 engages a distal inner surface 624 of the housing 602 when the plunger is in the initial position. The distal inner surface 624 functions as a stop that limits distal movement of the plunger 614 relative to the housing 602 and positions the plunger in the initial position. In the initial position, the plunger 614 is preferably spaced apart from the fluid port 20. In the second position, as the plunger moves proximally toward the second position, the outer edge of the flange 618 engages the inner surface of the housing 602. This engagement forms a seal between the plunger 614 and the housing 602, preventing or inhibiting fluid flow between the plunger and the housing.

[0041] The fluid passageway 608 includes a fluid chamber 626. The fluid chamber is defined by the plunger 614 (e.g., flange 618) and the housing 602. As described in more detail below, the fluid chamber 626 is configured to expand or increase in volume due to the application of a positive pressure (i.e., a positive pressure differential) from a pressure source (when the plunger 614 is in an initial position). The fluid chamber 626 is also configured to approximately collapse or decrease in volume due to the application of a negative pressure (i.e., a negative pressure differential) from a pressure source (when the plunger 614 is in a second position). As used herein, the phrase "positive pressure" refers to a pressure that is greater than the pressure of the environment surrounding the relative component to which the positive pressure is being applied, such as the port connector 600. For example, applying a positive pressure from a pressure source to the port connector 600 means that the pressure source applies a pressure to the port connector that is greater than the pressure of the environment surrounding the port connector (e.g., a chamber of a sterilization system in which the port connector is located). In other words, positive pressure creates a positive pressure difference between the environment surrounding the relative components and the pressure source, thereby causing fluid to flow from the pressure source toward the environment. Positive pressure can be above atmospheric pressure or below atmospheric pressure (vacuum). In certain preferred embodiments, the positive pressure is above atmospheric pressure.

[0042] The plunger 614 is configured to depress the fluid port upon application of positive pressure from a pressure source, causing the housing 602 and seal 610 to move distally relative to the fluid port 20, thereby moving the seal to a second location or position on the fluid port. Specifically, the plunger 614 moves proximally relative to the housing 602 due to the application of a pressure differential (i.e., positive pressure), expanding the fluid chamber 626 and depressing the fluid port 20. Thus, the plunger 614 engages the fluid port 20 as the plunger moves from the initial position to the second position. The plunger 614 generally forms a seal (e.g., a fluid-tight seal) with the housing 602 to prevent fluid flow between the inlet 604 and the outlet 606 as the plunger moves proximally from the initial position until application of positive pressure from the pressure source. Plunger recess 622 and slot 620 provide sufficient restraint on fluid flow so that upon application of positive pressure, positive pressure will move the plunger proximally so that flange 618 engages the inner surface of the housing.

[0043] By moving the seal 610 on the fluid port 20 by moving the plunger 614, a portion of the fluid port in the first position (that would otherwise be blocked or covered by the seal 610 when the port connector 600 was initially coupled to the fluid port) is exposed to fluid in the environment surrounding the fluid port of the article, contacting and sterilizing a portion of the surface at the first position. It will be understood that a portion of the surface at the second position was pre-sterilized by the fluid when the fluid was initially drawn through the port connector 600, as described below. Additionally, the plunger 614 is configured to move distally toward the initial position after the plunger depresses the fluid port 20 to reduce (e.g., collapse, contract) the volume of the fluid chamber 626 upon application of negative pressure from the pressure source.

[0044] In the illustrated embodiment, the distal portion of the inlet 604 is tapered (e.g., tapers radially inward as the inlet extends proximally). The plunger 614 (e.g., the tip of the shaft 616) is sized and configured to move along the inlet 604. The taper of the inlet 604 helps guide the plunger 614 into engagement with the fluid port 20. Additionally, preferably, the taper of the inlet 604 reduces the size of the inlet such that as the plunger moves proximally, it eventually engages a portion of the housing 602 that defines the inlet, thereby stopping further movement. This portion of the housing 602 thus limits the proximal movement of the plunger 614 and acts as a stop to position the plunger in the second position.

[0045] In operation, to sterilize an article having a fluid port 20, the port connector 600 is connected to the fluid port. When connected, the seal 610 engages the fluid port 20 in a first position. A pressure source is fluidly connected to the port connector 600 (e.g., outlet 606). The article with the fluid port 20 is placed in a chamber (e.g., a washing chamber). A fluid (e.g., a sterilizing fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before applying negative pressure. During this time, the fluid can move naturally or be forced around the chamber, contacting and sterilizing the surfaces of the article and the fluid port. The operator then applies negative pressure via the pressure source. The application of negative pressure moves (e.g., draws) the fluid through the fluid port 20 and the port connector 600 into the interior lumen of the article, thereby sterilizing the interior of the article. Fluid flows from the inlet 604, through the plunger recess 622 and slot 620, around the plunger 614, and into the outlet 606. As fluid enters the inlet 604, the fluid flows across to a second position on the fluid port 20. After a sufficient amount of fluid has been drawn through the article, an operator can apply positive pressure via a pressure source. As a result of the application of positive pressure, the seal 610 moves from a first position to a second position along the fluid port 20. As previously described, the application of positive pressure moves the plunger 614 relative to the housing 602 to move the seal 610. Specifically, the application of positive pressure expands the fluid chamber 626, forcing the plunger into contact with the fluid port 20. Once the plunger 614 contacts the fluid port 20, continued application of positive pressure continues to expand the fluid chamber 626 by moving the housing 602 (and therefore the seal 610) distally relative to the plunger (which now prevents further proximal movement due to engagement with the fluid port). In one method of operation, movement of the plunger 614 separates or disengages the port connector 600 (e.g., the seal 610) from the fluid port 20.Specifically, the plunger 614 not only moves the seal 610 to the second position, but also continues to move the seal until it no longer engages the fluid port 20, such as by sliding the seal from the distal end of the fluid port. In an alternative method of operation, after applying positive pressure, the operator can reapply negative pressure via the pressure source, thereby moving the plunger 614 distally back to its initial position. The reapplication of negative pressure creates a vacuum in the fluid chamber 626 that moves the plunger 614 distally relative to the housing 602 to its initial position. Once in the initial position, fluid can again flow freely around the plunger 614.

[0046] 24-27, another embodiment of a port connector in accordance with the present disclosure is indicated generally by the reference numeral 400. As shown in FIGS. 25 and 26, the port connector 400 is attached to a fluid port 10' of an article (not shown), such as an endoscope, to be sterilized. The fluid port 10' shown in FIGS. 25 and 26 is substantially similar to the previously described fluid port 10, except that the fluid port 10' does not have any barbs on its exterior. Instead, the fluid port 10' has a substantially smooth, cylindrical outer surface.

[0047] The port connector 400 includes a housing 402. The housing 402 has a proximal end and a distal end. The distal end (e.g., distal port) defines an outlet 406 configured to be fluidly coupled to a negative pressure source (broadly, a sterilizer). In other words, the outlet 406 is disposed in fluid communication with the negative pressure source. In the illustrated embodiment, the distal end is configured to be coupled to a fluid conduit or tubing to fluidly couple the outlet 406 to the negative pressure source. The distal end includes a barbed tube port fitting. The housing 406 also defines an inlet 404 configured to be fluidly coupled to the fluid port 10′, specifically the lumen 12 thereof. In other words, the inlet 404 is disposed in fluid communication with the fluid port 10′, specifically the lumen 12 thereof. The housing 402 defines a fluid passageway 408 (e.g., a lumen, a bore) that extends between and fluidly couples the inlet 404 and the outlet 406 (e.g., provides fluid communication between the inlet 404 and the outlet 406).

[0048] The port connector 400 of this embodiment includes a porous member 422 (broadly, a fluid port interface member). The porous member 422 is coupled to the housing 402. In the illustrated embodiment, the porous member 422 is attached to the housing 402. The porous member 422 is flexible, deformable, and has a generally tubular shape. The housing 402 includes a cylindrical wall 410. The porous member 422 has a proximal end and a distal end, both of which are coupled to the housing 402. The distal end of the porous member 422 is attached to the cylindrical wall 410 (e.g., the cylindrical wall is disposed within the porous member). The cylindrical wall 410 defines a portion of the fluid passageway 408. The housing 402 also includes a mounting ring 412. The mounting ring 412 is disposed proximal to the cylindrical wall 410 and the inlet 404. The proximal end of the porous member 422 is attached to the mounting ring 412. The connector 400 includes a retaining ring 414 (broadly, a retainer) that secures the porous member 422 (the proximal end of the porous member 422) to the mounting ring 412. In the illustrated embodiment, the porous member 422 folds back onto itself to be secured to the mounting ring 412. The proximal end of the porous member 422 bends around the mounting ring 412. The retaining ring 414 then clamps or secures the proximal end of the porous member 422 against the exterior of the mounting ring 412. The housing 402 includes one or more supports 416 for supporting the mounting ring 412. The supports 416 extend between the mounting ring 412 and the body of the housing 422, coupling the mounting ring 412 to the body of the housing 422.

[0049] The connector 400 defines a receiving chamber 418. The receiving chamber 418 is sized and configured to receive the fluid port 10′. A porous member 422 defines at least a portion of the receiving chamber 418. The inlet 404 of the housing 402 is in fluid communication with the receiving chamber 418. The inlet 404 is disposed in the portion of the receiving chamber 418 defined by the porous member 422. In the illustrated embodiment, the inlet 404 is disposed approximately adjacent to the distal end of the receiving chamber 418. The receiving chamber 418 includes a port or receiving inlet 420 ( FIG. 24 ). The port inlet 420 is sized and configured to receive the fluid port 10′ to allow the fluid port to be inserted into the receiving chamber 418. The port inlet 420 is disposed at a proximal end of the receiving chamber. In the illustrated embodiment, the port inlet 420 is defined by the porous member 422. The porous member 422 defines the proximal end of the port connector 400.

[0050] As shown in FIGS. 25 and 26 , the porous member 422 is positioned to engage with the fluid port 10′ when the port connector 400 is connected to the fluid port. Specifically, the porous member 422 (e.g., its interior or engagement surface) is positioned to engage with the fluid port 10′ when the fluid port is disposed within the receiving chamber 418. The porous member 422 is positioned to engage with the cylindrical outer surface of the fluid port 10′. Preferably, the porous member 422 is configured to form an interference fit or a friction fit with the fluid port 10′. The porous member 422 has an inner diameter at its narrowest point in the receiving chamber 418 (when the porous member is at rest and not being deflected by the fluid port 10′). The inner diameter is equal to, or more preferably smaller than, the outer diameter of the fluid port 10′. This ensures that the porous member 422 engages and deforms with the fluid port 10′, applying a force to the fluid port through elastic deformation to hold the port connector 400 thereon. 26 shows the porous member 422 in its resting, undeformed state, it is understood that the fluid port 10' deforms the porous member by expanding the port inlet 420 and / or the receiving chamber 418 (e.g., a portion of the receiving chamber) to allow the fluid port to be received in the port connector 400.

[0051] The porous member 422 has a porous structure that defines a plurality of randomly arranged, interconnected interstitial spaces, which form a plurality of micropassages 421 through and / or within the porous member. The porous member 422 is positioned relative to the remainder of the port connector 400 such that at least a portion of the micropassages 421 fluidly couple the receiving chamber 418 to the environment external to the port connector 400. Thus, when the port connector 400 is attached to the fluid port 10′, the porous member 422 does not form an absolute fluid-tight seal with the fluid port. Instead, fluid can migrate through the porous member 422 via the micropassages. However, as explained in more detail below, the port connector 400 can still be considered to form a fluid-tight seal (as defined herein) with the fluid port 10′ because the porous member 422 sufficiently impedes fluid flow through the fluid port 10′ such that fluid flows from other regions (e.g., to the end of the article's internal lumen opposite the fluid port) as a result of a pressure differential. Porous member 422 may be made of the same materials as described above for porous member 322 .

[0052] The porous member 422 allows sterilizing fluid in the environment surrounding the article's fluid port 10' to contact and sterilize the surfaces of the fluid port (e.g., end face 14, cylindrical exterior surface). When a negative pressure differential force is applied to the port connector 400 via a negative pressure source, sterilizing fluid moves (e.g., is drawn) through the porous member 422 (specifically, through at least some of the micropassages of the plurality of micropassages 421). Some of these micropassages 421 lead to and / or along the portion of the fluid port 10' with which the porous member 422 is engaged. As a result, as the sterilizing fluid moves through the porous member 422, the sterilizing fluid contacts the fluid port 10', thereby sterilizing the portion of the fluid port engaged by the porous member.

[0053] In one embodiment, as shown, the micropassages 421 of the porous member 422 are arranged substantially randomly throughout the porous member. In one embodiment, a porosity control material or coating 425 (FIG. 26) is applied to the porous member 422. For example, the porosity control material 425 may be applied to one or more surfaces (e.g., the outer surface) of the porous member 422. The porosity control material 425 may be applied to the entire surface of the porous member 422, or to only a portion of the surface. The porous member 422 may be interlocked with or coated with the porosity control material 425. By applying the porosity control material 425 to one or more surfaces of the porous member 422, a flow path can be defined through the porous member rather than relying on the randomness of the micropassages 421. The porosity control material 425 at least partially blocks at least some of the micropassages 421 in the porous member 422 to control how and where the sterilizing fluid flows through the porous member. The porosity control material 425 may completely block the micropassages 421 or may only partially block (e.g., cover) the micropassages with which it is aligned. The porosity control material 425 may also increase the resistance to the flow of sterilizing fluid through the porous member 422 so that an appropriate amount of sterilizing fluid is also drawn through the article. Preferably, the resistance to the flow of sterilizing fluid through the article and the porous member 422 is relatively similar so that sterilizing fluid is drawn through both the porous member and the article when a pressure differential is applied by the sterilizer. By applying the porosity control material 425 to the porous member 422, a fluid path can be more easily defined (via the micropassages 421) through the porous member closest to or in contact with the fluid port 10′ (e.g., the surface of the fluid port), more reliably ensuring that the sterilizing fluid contacts the fluid port as it flows through the porous member. For example, in one embodiment, the porosity control material 425 is disposed distal to the proximal end of the porous member 422, thereby defining a fluid path along the outer surface of the port 10′ into the proximal end of the porous member and into the receiving chamber 418. The porosity control material 425 may be non-porous or may have a porosity less than that of the porous member 422.The porosity control material 425 can be made of any suitable material, such as polytetrafluoroethylene (PTFE).

[0054] 26 and 27 , the housing 402 includes a stopper 424. The stopper 424 is positioned to engage the fluid port 10′ to position the fluid port within the receiving chamber 418. The stopper 424 is positioned to engage the distal end 14 of the fluid port 10′. The stopper 424 limits distal movement of the fluid port 10′ relative to the port connector 400 in an insertion direction. The insertion direction is the direction in which the fluid port 10′ moves relative to the port connector 400 when the port connector is connected to the fluid port, i.e., the direction in which the fluid connector is inserted into the port inlet 420. In the illustrated embodiment, the stopper 424 includes a lip that is positioned to engage the fluid port 10′. The lip is positioned at the proximal end of the cylindrical wall 410. Preferably, the stopper 424 is the only portion of the housing 402 that is positioned to engage the fluid port 10′ to prevent the housing from otherwise obstructing the flow of sterile fluid around the fluid port 10′. Preferably, the stopper 424 allows sterile fluid to flow between the stopper and the fluid port 10′ when the stopper is engaged with the fluid port and a pressure differential is applied. Thus, the narrow edged engagement of the stopper 424 disclosed herein does not form a seal with the fluid port 10′, thereby allowing sterile fluid to flow between the stopper and the fluid port. In one embodiment, the stopper 424 can define a recess or channel (not shown) to further facilitate the flow of sterile fluid between the stopper and the fluid port 10′. In the illustrated embodiment, the stopper 424 defines the inlet 404.

[0055] The port connector 400 can include a port guide 426. The port guide 426 is configured to generally align the lumen 12 of the fluid port 10′ with the inlet 404. The port guide 426 is sized and shaped to be received in the lumen 12 of the fluid port 10′. In the illustrated embodiment, a portion of the port guide 426 is disposed in the fluid passageway 408. The port guide 426 is attached to an interior wall of the housing 402 (generally, the port guide is part of the housing). The interior wall defines one or more openings 428 ( FIG. 27 ) that are part of the fluid passageway 408 and allow sterile fluid to flow therethrough as the sterile fluid flows from the inlet 404 to the outlet 406. The port guide 426 extends proximally from the interior wall of the housing 402. The port guide 426 extends through the inlet 404. In the illustrated embodiment, the port guide 426 has a generally frusto-conical shape, although other shapes are within the scope of the present disclosure. The port guide 426 ensures that the fluid port 10' is properly positioned relative to the port connector 400 when the port connector is attached to the fluid port.

[0056] In operation, to sterilize an article having a fluid port 10′, the port connector 400 is connected to the fluid port by inserting the fluid port into the receiving chamber 418 through the port inlet 420. As previously described, the porous member 422 engages with the fluid port 10′. A negative pressure source of the sterilization device is fluidly connected to the port connector 400 (e.g., outlet 406). The article with the fluid port 10′ is placed in a chamber (e.g., a washing chamber). A fluid (e.g., a sterilizing fluid) is supplied or introduced into the chamber. The fluid can remain in the chamber for a period of time, such as 5 to 10 minutes, before applying negative pressure. During this time, the fluid can move naturally or be forced around the chamber, contacting and sterilizing surfaces of the article and the fluid port, such as exposed surfaces. The fluid can also move into and through the porous member 422. The operator then applies a pressure differential (e.g., a negative pressure differential) via the negative pressure source. As a result, the negative pressure differential moves (e.g., draws) sterilizing fluid from the chamber through the porous member and into the receiving chamber 418. As the sterilizing fluid moves through some of the microchannels 421 of the porous member 422, it contacts the cylindrical outer surface, thereby sterilizing the portion of the fluid port 10′ engaged by the port connector. After the sterilizing fluid enters the receiving chamber 418, it moves around the fluid port 10′, sterilizing the remaining fluid ports contained in the receiving chamber before the sterilizing fluid enters the inlet 404 of the port connector 400. It is believed that aligning the inlet 404 with the porous member 422 (e.g., lateral alignment) results in a more substantial flow of sterilizing fluid through the porous member. Additionally, the negative pressure differential moves (e.g., draws) sterilizing fluid into the internal lumen of the article, through the internal lumen, and through the fluid port 10′ and the port connector 400, thereby sterilizing the interior of the article. The movement of sterilizing fluid through the article and the porous member 422 generally occurs simultaneously. The sterilizing fluid drawn through the article and porous member 422 is then drawn through the port connector 400 and moves towards the negative pressure source.Thus, even though the port connector 400 is attached to the fluid port 10 during the sterilization process, the entire fluid port is generally exposed to the sterilizing fluid and sterilized.

[0057] The following are descriptions of exemplary embodiments described in this disclosure. Although some of the following descriptions are not currently presented as claims, these descriptions are believed to be patentable and may be later presented as claims. Related methods corresponding to the following descriptions or apparatus or systems are also believed to be patentable and may be later presented as claims. Similarly, related apparatus or systems corresponding to the following descriptions or methods are also believed to be patentable and may be later presented as claims. It is understood that the following descriptions may refer to and be supported by one, more than one, or all of the above embodiments.

[0058] A1. A port connector for connecting to a fluid port of a device to be sterilized to a negative pressure source of a sterilizer, comprising: a housing configured to couple to the fluid port, the housing having a proximal end defining an inlet configured to be fluidly coupled to the fluid port, and a distal end defining an outlet configured to be fluidly coupled to the negative pressure source, the housing defining a fluid passageway extending between the inlet and the outlet fluidly coupling the inlet and the outlet; and a gasket supported by the housing so as to be spaced from the fluid port when the housing is coupled to the fluid port, the gasket configured to move toward the fluid port to engage and form a fluid-tight seal with the fluid port upon application of negative pressure from the negative pressure source to draw fluid through the fluid port.

[0059] A2. The port connector of statement A1, wherein the proximal end includes an insert sized and configured to be inserted into the fluid port, the insert defining an inlet.

[0060] A3. The port connector of any one of descriptions A1-A2, wherein the gasket includes a bendable flange that is configured to move toward the fluid port upon application of negative pressure to engage with the fluid port and form a fluid-tight seal therewith.

[0061] A4. The port connector of any one of descriptions A1-A2, wherein the housing includes a plunger supporting a gasket, the plunger configured to move proximally upon application of negative pressure to move the gasket toward the fluid port so that the gasket engages with the fluid port and forms a fluid-tight seal therewith.

[0062] A5. The port connector of any one of statements A1-A4, wherein the fluid passage defined by the housing includes a fluid chamber, the fluid chamber configured to substantially collapse due to application of a negative pressure.

[0063] A6. A port connector of any one of descriptions A1 to A5, wherein the housing includes a connector body and a slide movably supported by the connector body, the slide operably coupled to the plunger such that movement of the slide results in movement of the plunger.

[0064] A7. A port connector of any one of descriptions A1-A6, wherein the connector body and slide at least partially define a fluid chamber, and the slide moves proximally relative to the connector body due to application of negative pressure to substantially collapse the fluid chamber and move the plunger proximally to move the gasket toward the fluid port so that the gasket engages with the fluid port and forms a fluid-tight seal with the fluid port.

[0065] A8. The port connector of any one of descriptions A1-A7, wherein the plunger defines an inlet, the plunger further defining at least one plunger opening fluidly communicating with the fluid chamber, and an elongated bore fluidly coupling the inlet and the at least one plunger opening.

[0066] A9. The port connector of any one of statements A1-A8, wherein the slide defines at least one slide passageway fluidly coupling the fluid chamber to the outlet.

[0067] A10. The port connector of any one of statements A1-A9, wherein the housing includes a coupler configured to couple to the fluid port.

[0068] A11. The port connector of any one of statements A1 to A10, wherein the coupler comprises a first resiliently deflectable clip and a second resiliently deflectable clip, the first and second clips configured to engage with the fluid port to couple the port connector to the fluid port.

[0069] A12. The port connector of any one of statements A1-A11, wherein the first and second clips each include a retainer configured to engage with the fluid port to secure the port connector to the fluid port.

[0070] B1. A method for sterilizing a device having a fluid port, comprising the steps of connecting a port connector to the fluid port, the port connector having an inlet in fluid communication with the fluid port, an outlet, and a fluid passage extending between the inlet and the outlet to fluidly connect the inlet and the outlet; fluidly connecting a negative pressure source to the outlet of the port connector; forming a fluid-tight seal between the port connector and the fluid port by moving a gasket of the port connector toward and engaging the fluid port; and moving a sterilizing fluid through the fluid port and the port connector.

[0071] B2. The method of statement B2, further comprising placing the device in a washing chamber and providing sterilizing fluid to the washing chamber before transferring the sterilizing fluid.

[0072] B3. The method of any one of statements B1-B2, wherein the gasket includes a bendable flange and the fluid-tight seal is formed by bending the bendable flange to move the bendable flange toward and engage the fluid port.

[0073] B4. The method of any one of statements B1-B3, wherein the port connector includes a plunger supporting a gasket, and the step of forming a fluid-tight seal includes the step of moving the plunger to move the gasket toward and engage the fluid port.

[0074] B5. The method of any one of statements B1-B4, wherein the port connector includes a connector body and a slide movably supported by the connector body, the slide operably connected to the plunger such that movement of the slide results in movement of the plunger, and the step of forming a fluid-tight seal includes moving the slide relative to the connector body to move the plunger, thereby moving the gasket toward the fluid port to engage with the fluid port.

[0075] B6. The method of any one of statements B1-B5, wherein the connector body and slide at least partially define a fluid chamber of the fluid passage, and the step of forming a fluid-tight seal includes a step of moving the slide relative to the connector body by creating a vacuum in the fluid chamber, substantially collapsing the fluid chamber as a result of the vacuum.

[0076] B7. The method of any one of statements B1-B6, wherein the gasket is spaced from the fluid port prior to the step of forming a fluid-tight seal.

[0077] B8. The method of any one of statements B1-B7, wherein the port connector includes a coupler for connecting the port connector to the fluid port.

[0078] B9. The method of any one of statements B1-B8, wherein the step of forming a fluid-tight seal includes applying a negative pressure to the port connector via a negative pressure source.

[0079] B10. The method of any one of statements B1-B9, wherein the step of moving a sterile fluid includes drawing sterile fluid through the fluid port and port connector by application of negative pressure from a negative pressure source.

[0080] C1. A port connector for connecting to a fluid port of a device to be sterilized to a pressure source of a sterilizer, the port connector comprising: a housing configured to couple to the fluid port, the housing having a proximal end defining an inlet configured to be fluidly coupled to the fluid port and a distal end defining an outlet configured to be fluidly coupled to a negative pressure source, the inlet being fluidly coupled to the outlet; a seal supported by the housing and configured to engage the fluid port at a first position; and a piston movably disposed within the housing, the piston configured to press against the fluid port upon application of positive pressure from the pressure source to move the housing and seal distally relative to the fluid port and move the seal to a second position on the fluid port.

[0081] C2. The port connector of description C1, wherein at least the piston and the housing define a fluid chamber, the fluid chamber configured to expand due to application of positive pressure.

[0082] C3. The port connector of any one of descriptions C1-C2, wherein the piston moves proximally relative to the housing due to application of positive pressure to expand the fluid chamber and press against the fluid port.

[0083] C4. The port connector of any one of descriptions C1-C3, wherein the piston is movable from an initial position, in which the piston is configured to allow fluid to flow between the inlet and the outlet.

[0084] C5. The port connector of any one of descriptions C1-C4, wherein the piston is configured to move proximally from an initial position to press against the fluid port, and the piston substantially forms a fluid-tight seal with the housing as the piston moves proximally upon application of positive pressure to prevent fluid flow between the outlet and inlet.

[0085] C6. The port connector of any one of descriptions C1-C5, wherein the piston includes one or more slots configured to allow fluid flow around the piston.

[0086] C7. The port connector of any one of descriptions C1-C6, wherein the piston is configured such that upon application of negative pressure from the pressure source, the piston presses against the fluid port to contract the fluid chamber and then moves distally toward the initial position.

[0087] D1. A method for sterilizing a device having a fluid port, comprising the steps of: connecting a port connector to the fluid port such that a seal of the port connector engages the fluid port in a first position; fluidly connecting a pressure source to an outlet of the port connector; and applying pressure from the pressure source to move a piston of the port connector relative to a housing of the port connector to move the seal to a second position over the fluid port.

[0088] D2. The method of statement D1, wherein moving the piston includes applying positive pressure from a pressure source.

[0089] E1. A port connector for connecting to a fluid port of a device to be sterilized to a sterilizer, the fluid port defining a lumen, the port connector comprising: a porous member having a porous structure defining a plurality of micropassages, the porous member defining at least a portion of a receiving chamber sized and shaped to receive the fluid port, the porous member being positioned such that an inner surface of the porous member engages the fluid port when the fluid port is positioned within the receiving chamber; and a housing coupled to the porous member, the housing defining an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to the sterilizer, and a fluid passage extending between and fluidly coupling the inlet and the outlet, the inlet being positioned in at least a portion of the receiving chamber defined by the inner surface of the porous member.

[0090] E2. The port connector of description E1, wherein at least a portion of the micropassages of the porous member fluidly couple the receiving chamber to an environment external to the port connector.

[0091] E3. The port connector of any one of statements E1-E2, wherein the porous member is configured to form an interference fit with the fluid port.

[0092] E4. The port connector of any one of descriptions E1-E3, wherein the porous member has an inner diameter at the narrowest point of the receiving chamber, the inner diameter being less than or equal to the outer diameter of the fluid port.

[0093] E5. The port connector of any one of statements E1-E4, wherein the porous member has a generally tubular shape.

[0094] E6. The port connector of any one of descriptions E1-E5, wherein the housing includes a stopper positioned to engage the fluid port and position the fluid port within the receiving chamber.

[0095] E7. The port connector of any one of descriptions E1 to E6, wherein the stopper limits movement of the fluid port relative to the connector in an insertion direction, the insertion direction being the direction in which the fluid port moves relative to the port connector when the port connector is connected to the fluid port.

[0096] E8. The port connector of any one of descriptions E1-E7, wherein the stopper is positioned to engage a distal end of the fluid port.

[0097] E9. The port connector of any one of descriptions E1-E8, wherein the stopper includes a lip, the lip being positioned to engage the fluid port.

[0098] E10. The port connector of any one of statements E1-E9, wherein the only portion of the housing positioned to engage the fluid port is an edge of the stopper.

[0099] E11. The port connector of any one of descriptions E1-E10, further comprising a guide configured to generally align the lumen of the fluid port with the inlet.

[0100] E12. The port connector of any one of statements E1-E11, wherein the guide is dimensioned and configured to be received within the lumen of the fluid port.

[0101] E13. A port connector of any one of descriptions E1 to E12, wherein the guide extends through the inlet.

[0102] E14. The port connector of any one of descriptions E1-E13, wherein the guide is part of the housing and the guide extends proximally from an inner wall of the housing.

[0103] E15. The port connector of any one of statements E1-E14, wherein the porous member defines a proximal end of the port connector.

[0104] E16. The port connector of any one of descriptions E1-E15, wherein the porous member defines a receiving inlet at a proximal end of the receiving chamber, the receiving inlet being dimensioned and configured to receive the fluid port.

[0105] E17. The port connector of any one of statements E1-E16, wherein the porous member has a proximal end and a distal end, the proximal end and the distal end being coupled to the housing.

[0106] E18. The port connector of any one of statements E1-E17, wherein the housing includes a cylindrical wall and a mounting ring, the distal end of the porous member being mounted to the cylindrical wall and the proximal end of the porous member being mounted to the mounting ring.

[0107] E19. The port connector of any one of statements E1-E18, further comprising a retaining ring, the retaining ring securing the proximal end of the porous member to the mounting ring.

[0108] E20. The port connector of any one of descriptions E1 to E19, wherein the proximal end is bent around a mounting ring.

[0109] E21. The port connector of any one of statements E1-E20, wherein the housing includes one or more supports that support the mounting ring.

[0110] E22. A port connector of any one of statements E1 to E21 in combination with a fluid port, the fluid port having no barbs on its exterior.

[0111] E23. The port connector of any one of statements E1-E22, wherein the fluid port has a generally cylindrical outer surface, the outer surface being smooth.

[0112] F1. A port connector for connecting a fluid port of a device to be sterilized to a sterilizer, the port connector comprising: a housing configured to mate with the fluid port and defining an outlet configured to be fluidly coupled to the sterilizer; a seal arranged to form a fluid-tight seal with the fluid port; and a piston supported by the housing and movable relative to the housing upon application of a pressure differential by the sterilizer.

[0113] F2. The port connector of description F1, wherein the seal is supported by the piston and moves with the piston upon application of a pressure differential to engage the fluid port and form a fluid-tight seal therewith.

[0114] F3. The port connector of any one of descriptions F1-F2, wherein the seal is configured to engage with the fluid port in a first position and the piston is configured to press against the fluid port upon application of a pressure differential to move the seal to a second position over the fluid port.

[0115] It is clear and understood that the elements, features, and / or teachings described in each embodiment disclosed herein are not limited to the particular embodiment in which the element, feature, and / or teaching is described. Thus, it is clear and understood that elements, features, and / or teachings described in one embodiment may be applied to one or more of the other embodiments disclosed herein.

[0116] When introducing elements of the invention or embodiments thereof, the articles "a," "an," "the," and "said" are intended to mean that there are one or more elements. The terms "comprising," "including," and "having" are intended to be inclusive and mean that there may be additional elements other than the listed elements.

[0117] Modifications and variations of the disclosed embodiments are possible without departing from the scope of the invention, as defined in the appended claims. For example, where specific dimensions are given, it will be understood that they are exemplary only and that other dimensions are possible. Because various changes can be made in the structures, products, and methods described above without departing from the scope of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawings be interpreted as illustrative and not in a limiting sense.

Claims

1. 1. A port connector for connecting to a fluid port of a device to be sterilized to a sterilization apparatus, the fluid port having a distal end defining a fluid port outlet, the fluid port defining a lumen extending proximally from the fluid port outlet, the port connector comprising: a housing configured to couple to the fluid port, the housing defining an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to the sterilization device, and a fluid passageway extending between the inlet and the outlet fluidly coupling the inlet and the outlet; a porous member supported by the housing, the porous member having a porous structure defining a plurality of micropassages, the porous member being positioned relative to the housing to engage the distal end of the fluid port when the port connector is connected to the fluid port; A port connector comprising:

2. 2. The port connector of claim 1, wherein the porous member is positioned relative to the housing such that, when the port connector is connected to the fluid port, at least a portion of the micropassage fluidly couples the fluid port outlet to an environment external to the port connector.

3. The port connector of claim 1 or 2, wherein the porous member is positioned relative to the housing such that the porous member covers a portion of the fluid port outlet.

4. The port connector of claim 1 , wherein the porous member includes an annular surface positioned to engage the distal end of the fluid port.

5. The port connector of claim 4 , wherein the annular surface has an inner diameter that is smaller than a diameter of the fluid port outlet.

6. The port connector of claim 5 , wherein the annular surface has an outer diameter greater than a diameter of the fluid port outlet.

7. The port connector of claim 1 , wherein the housing includes an insert sized and configured to be inserted into the fluid port outlet, the insert defining the inlet.

8. The port connector of claim 7 , wherein the porous member is supported by the insert.

9. The port connector of claim 1 , wherein the housing includes a coupler configured to couple the port connector to the fluid port.

10. 10. The port connector of claim 9, wherein the coupler comprises a first resiliently deflectable clip and a second resiliently deflectable clip, the first and second clips configured to engage with the fluid port to couple the port connector to the fluid port.

11. The port connector of claim 10 , wherein the first and second clips each include a retainer configured to engage the fluid port to secure the port connector to the fluid port.

12. 1. A method for sterilizing a device having a fluid port, comprising: connecting a port connector to the fluid port, the port connector defining an inlet in fluid communication with the fluid port, an outlet, and a fluid passage extending between the inlet and the outlet to fluidly connect the inlet and the outlet, the port connector having a porous member engaging an end of the fluid port; fluidly connecting a sterilization device to the outlet of the port connector; sterilizing the end of the fluid port by moving a sterile fluid through the porous member while the port connector is connected to the fluid port; A method comprising:

13. 13. The method of claim 12, further comprising sterilizing the device with the sterilizing fluid while the port connector is connected to the fluid port.

14. 14. The method of claim 12 or 13, wherein the step of sterilizing the device comprises moving the sterilizing fluid through the lumen of the device, through the fluid port, and through the port connector.

15. 15. The method of claim 14, wherein the step of moving the sterile fluid through the lumen, the fluid port, and the port connector comprises drawing the sterile fluid through the lumen, the fluid port, and the port connector by application of a pressure differential from a pressure source.

16. 16. The method of any one of claims 12 to 15, wherein the steps of sterilizing the end of the fluid port and sterilizing the device are performed substantially simultaneously.

17. 17. The method of any one of claims 12 to 16, further comprising the steps of placing the device in a washing chamber and supplying the sterilizing fluid to the washing chamber before transferring the sterilizing fluid.

18. 1. A port connector for connecting to a fluid port of a device to be sterilized to a sterilization apparatus, the fluid port defining a lumen, the port connector comprising: a porous member having a porous structure defining a plurality of micropassages, the porous member defining at least a portion of a receiving chamber sized and shaped to receive the fluid port, the porous member being positioned such that an inner surface of the porous member engages the fluid port when the fluid port is positioned within the receiving chamber; a housing coupled to the porous member, the housing defining an inlet configured to be fluidly coupled to the lumen of the fluid port, an outlet configured to be fluidly coupled to the sterilization apparatus, and a fluid passageway extending between the inlet and the outlet to fluidly couple the inlet and the outlet, the inlet being disposed in at least a portion of the receiving chamber defined by the inner surface of the porous member; A port connector comprising:

19. 20. The port connector of claim 18, wherein at least a portion of the micropassages in the porous member fluidly couple the receiving chamber to an environment external to the port connector.

20. 20. The port connector of claim 18 or 19, wherein the porous member is configured to form an interference fit with the fluid port.

21. 21. A port connector according to any one of claims 18 to 20, further comprising a porosity control material coating one or more surfaces of the porous member to define a flow path through the porous member.

Images