Composition for improving or maintaining mood, and composition for improving or maintaining quality of sleep

Abstract

To provide a composition that enables improvement or maintenance of mood, and improvement or maintenance of quality of sleep.SOLUTION: A composition contains Garcinia indica and / or garcinol.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition for improving or maintaining mood, which contains Garcinia indica, and a composition for improving or maintaining sleep quality. The present invention also relates to a composition for improving or maintaining mood, which contains garcinol, and a composition for improving or maintaining sleep quality. [Background technology]

[0002] Mood and vitality are extremely important for living a meaningful and healthy daily life. However, in recent years, a decline in daily activity, aging, fatigue, nutritional deficiencies, and other factors have led to a decline in motivation, energy, and vitality, making it difficult to live a meaningful and healthy daily life. As compositions for improving and maintaining vitality, drugs containing thioctic acids as active ingredients (Patent Document 1) and drugs containing β-alanyl leucine and the like as active ingredients (Patent Document 2) have been reported. However, thioctic acid and β-alanyl leucine can have side effects and require caution when combined with other ingredients. Therefore, it is believed that more options are needed for compositions for improving and maintaining mood.

[0003] Another factor that can cause mood depression is poor sleep quality, such as sleep deprivation. Sesamin compounds (Patent Document 3) and lactoferrin (Patent Document 4) are known to be effective materials for improving sleep quality. However, the compositions developed so far are not necessarily sufficiently effective, so there is a need to develop new compositions that are excellent at improving sleep quality. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2007-308468 [Patent Document 2] Japanese Patent Application Laid-Open No. 2008-255087 [Patent Document 3] Japanese Patent Application Laid-Open No. 2016-188234 [Patent Document 4] Japanese Patent Application Publication No. 2018-043964 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide a composition that can improve or maintain mood and improve or maintain the quality of sleep.

[0006] The present inventors have conducted extensive research to solve the above problems and have surprisingly found that Garcinia indica has excellent mood-enhancing or mood-maintaining effects, as well as the effect of improving or maintaining sleep quality. Furthermore, the present inventors have conducted extensive research to solve the above problems and have surprisingly found that garcinol has excellent mood-enhancing or mood-maintaining effects, as well as the effect of improving or maintaining sleep quality. The present invention was completed based on these findings.

[0007] The outline of the present invention is as follows. [1] A mood enhancing or maintaining composition containing Garcinia indica. [2] A composition for improving or maintaining mood, characterized by containing garcinol. [3] A composition for improving or maintaining mood according to [1] or [2], wherein the mood improvement or maintenance is at least one selected from the reduction or maintenance of decreased vitality and energy, the reduction or maintenance of fatigue, the reduction or maintenance of irritability, the reduction or maintenance of confusion, the reduction or maintenance of depression, the reduction or maintenance of anxiety, the improvement or maintenance of mental health, the reduction or maintenance of stress, and the improvement or maintenance of motivation. [4] A composition for improving or maintaining sleep quality, characterized by containing Garcinia indica. [5] A composition for improving or maintaining sleep quality, characterized by containing garcinol. [6] A composition for improving or maintaining sleep quality according to [4] or [5], wherein the improvement or maintenance of sleep quality is at least one selected from reducing or maintaining sleepiness upon waking, promoting or maintaining sleep onset, increasing or maintaining sleep time, reducing or maintaining dreaminess, reducing or maintaining fatigue upon waking, shortening or maintaining the time spent awake during the night, and improving or maintaining satisfaction with sleep. [Effects of the Invention]

[0008] The composition of the present invention exhibits excellent mood improving or maintaining effects, as well as effects of improving or maintaining the quality of sleep. DETAILED DESCRIPTION OF THE INVENTION

[0009] The present invention will be described in detail below, but the present invention is not limited to the following embodiments.

[0010] [Garcinia indica] The composition of the present invention is characterized by containing Garcinia indica, a plant (scientific name: Garcinia indica) of the family Hypericaceae, genus Garcinia (also known as Garcinia), also known as kokum, Indian mangosteen, kofano mangosteen, wild mangosteen, red mangosteen, etc.

[0011] There are no particular limitations on the parts of Garcinia indica that can be used, and leaves, fruits, and other parts can be used in any suitable combination. However, the fruits are preferred, and the flesh and peel are particularly preferred, as they can more effectively exert the effects of the present invention.

[0012] In the present invention, Garcinia indica may be harvested and used as is, or processed Garcinia indica (Garcinia indica processed product). When using processed Garcinia indica, pulverized products such as powders and granules, squeezed juices, and extracts can be used. The squeezed juices and extracts may be in liquid or slurry form, but dried powders are preferred. Among these, pulverized products and extracts are preferred, with extracts being particularly preferred, as they can more effectively achieve the effects of the present invention. In the present invention, the term "extract" encompasses dried powders of extracts (extracts dried and powdered). The Garcinia indica processed product may be produced by methods commonly known to those skilled in the art or may be commercially available.

[0013] In the present invention, Garcinia indica extract can be in the form of an extract liquid, a diluted or concentrated liquid thereof, or a dried powder thereof. Solvents used for extraction include, for example, water; lower alcohols such as methanol, ethanol, isopropanol, and butanol; lower esters such as ethyl acetate and methyl acetate; acetone; and mixtures of these with water. Among these, polar solvents are preferred for achieving greater effectiveness, with water, ethanol, or a mixture of water and ethanol being more preferred, and ethanol being the most preferred.

[0014] When extracting with a polar solvent, the extraction method is not particularly limited; continuous extraction, immersion extraction, countercurrent extraction, etc. can be suitably selected, and any suitable device can be used at room temperature or under reflux heating. The extract can be concentrated and dried as needed. When the extract is made into a dry powder, excipients may be added as needed. Note that, in this specification, when Garcinia indica extract contains excipients, the content of the excipients is the amount excluding the excipients.

[0015] [Garcinol] The composition of the present invention is characterized by containing garcinol, a type of polyisoprenylated benzophenone derivative contained in plants of the genus Garcinia (also known as Garcinia) of the family Hypericaceae.

[0016] The garcinol contained in the composition of the present invention may be purified or may be derived from a plant containing garcinol, but from the viewpoint of safety when taken orally, it is preferable to use a plant containing garcinol. As a plant containing garcinol, a plant of the genus Garcinia (also known as Garcinia) of the family Hypericaceae is preferably used, with Garcinia indica, Garcinia cambogia, Garcinia atroviridis, Garcinia mangostana, and Garcinia subelliptica being more preferred, and Garcinia indica being particularly preferred because it can achieve higher effects.

[0017] The amount of garcinol in the composition of the present invention can be analyzed by HPLC. For example, it can be measured using an HPLC analyzer equipped with an ultraviolet absorption detector. The analytical column is a Unison UK-C18 HT 3 μm diameter x 150 mm column manufactured by Imtakt. The mobile phase is 0.1% acetic acid (mobile phase A) and acetonitrile (mobile phase B). The column temperature is 40°C and the flow rate is 1.0 mL / min. The gradient conditions are as follows:

[0018] [Table A]

[0019] In addition to Garcinia indica and garcinol, the compositions of the present invention may contain other ingredients as needed. Examples of such ingredients include excipients, lubricants, dietary fiber (e.g., soluble or insoluble dietary fiber), proteins, various vitamins and minerals, and microorganisms (e.g., algae and yeast). Furthermore, ingredients commonly used in the food industry, such as sweeteners, acidulants, nutritional supplements, stabilizers, binders, glazing agents, thickeners, colorants, diluents, emulsifiers, food additives, and seasonings, may also be included as needed. The amount of these other ingredients may be appropriately selected depending on the form of the composition of the present invention.

[0020] As described in the Examples below, the composition of the present invention has the effect of improving or maintaining mood and the effect of improving or maintaining sleep quality, and therefore can be used as a composition for improving or maintaining mood and the quality of sleep. Furthermore, the composition of the present invention has an antioxidant effect, which prevents damage to nerve cells caused by reactive enzyme species and protects the brain, thereby achieving the effect of improving or maintaining mood and the effect of improving or maintaining sleep quality.

[0021] In the present invention, mood is represented by at least one selected from the group consisting of, for example, a sense of vitality and vigor (e.g., being clear-headed, lively, and in a positive mood), a sense of fatigue, a sense of irritability (e.g., being easily put into a bad mood, being easily angered by others), a sense of confusion (e.g., being confused), a sense of depression, a sense of anxiety, mental health (e.g., being in a happy and calm mood), and stress.

[0022] The composition of the present invention has mood-enhancing or maintaining effects, such as reducing or maintaining a decrease in vitality and energy, reducing or maintaining fatigue, reducing or maintaining irritability, reducing or maintaining confusion, reducing or maintaining depression, reducing or maintaining anxiety, improving or maintaining mental health, reducing or maintaining stress, and improving or maintaining motivation.

[0023] The mood-enhancing or mood-maintaining effect can be evaluated by a conventionally known method without particular limitation, for example, by POMS, SF-36, VAS, etc.

[0024] There are no particular limitations on the composition for mood enhancement or maintenance, as long as it contains Garcinia indica and / or garcinol and can be distinguished from other products in that it exhibits mood enhancement or maintenance functions. For example, the scope of the present invention includes products that display the function of improving mood enhancement or maintenance on the main body, packaging, instructions, or promotional materials (advertising media) of the product of the present invention.

[0025] Specifically, the effects are as follows: "reducing temporary decline in vitality and energy", "reducing temporary decline in vitality and energy (feeling lively, feeling positive, full of motivation and energy, clear-headedness, etc.)", "maintaining a positive mood (being clear-headed, feeling lively, feeling positive, feeling energized, etc.)", "reducing temporary decline in vitality (feeling full of energy, full of vitality, etc.)", "reducing fatigue in daily life", "reducing fatigue after exercise", "reducing fatigue in daily life and after exercise", "reducing fatigue associated with cold", "raising the temperature around the stomach area". Examples of such health foods include those labeled as "reduces fatigue," "relieves listlessness," "for persistent fatigue," "for daily fatigue," "supports high physical and mental performance," "improves fatigue," "for those who tire easily," "reduces temporary irritability," "reduces temporary confusion," "reduces temporary depression," "reduces temporary anxiety," "maintains mental health (a happy and calm mood)," "reduces temporary stress," "reduces temporary mental stress," "reduces psychological stress," etc., as well as health foods that claim to have the listed functions. Furthermore, functional foods also include those whose scientific evidence of functionality is mood improvement or maintenance.

[0026] The mood-enhancing or mood-maintaining compositions of the present invention may label Garcinia indica and / or garcinol as the active ingredient, but are not limited to those labeled with Garcinia indica or garcinol as the active ingredient on the product packaging. For example, they may be products without a specific active ingredient. Furthermore, even general foods that are manufactured and sold with a suggested intended use are within the scope of the present invention. For example, foods sold with personal testimonials from people who have consumed them, mentioning their mood enhancement or maintenance, are also within the scope of the present invention.

[0027] In the present invention, sleep quality is indicated by at least one item selected from the group consisting of, for example, sleepiness upon waking, sleep onset and sleep maintenance (e.g., smooth sleep onset and sleep maintenance, or falling asleep quickly and continuing a stable sleep without waking up during the night), dreaminess (e.g., not having frequent dreams or nightmares), fatigue upon waking, waking up during the night, and satisfaction with sleep (e.g., not feeling short of time).

[0028] The composition of the present invention has the effect of improving or maintaining the quality of sleep, for example, reducing or maintaining sleepiness upon waking, promoting or maintaining sleep onset, increasing or maintaining sleep time, reducing or maintaining dreaminess, reducing or maintaining fatigue upon waking, shortening or maintaining the time spent awake during the night, and improving or maintaining satisfaction with sleep.

[0029] The effect of improving or maintaining the quality of sleep can be evaluated by a conventionally known method without any particular limitation, for example, by the OSA sleep questionnaire, VAS, etc.

[0030] Compositions for improving or maintaining sleep quality are not particularly limited as long as they contain Garcinia indica and / or garcinol and can be distinguished from other products in that they have the function of improving or maintaining sleep quality. For example, the scope of the present invention includes products that display the function of improving or maintaining sleep quality on the main body, packaging, instructions, or promotional materials (advertising media) of the product of the present invention.

[0031] Specific examples include health foods that claim to "improve sleep quality," "improve sleep quality (depth of sleep, satisfaction with sleep upon waking)," "improve feeling of deep sleep," "reduce the number of awakenings during sleep," "reduce the time spent waking during sleep," "improve sleep depth," "improve satisfaction with sleep depth," "improve sleep rhythm," "improve daytime sleepiness," "improve satisfaction upon waking," "improve feeling of extended sleep time," "support quality sleep at night," "sleep support," "sleep improvement," "reduce sleepiness upon waking," "reduce fatigue upon waking," "support quality sleep," "relieve daytime sleepiness," "improve satisfaction with sleep," etc., as well as health foods that claim to have the listed functions reported. Furthermore, functional foods include those whose scientific evidence for their functionality is the improvement or maintenance of sleep quality.

[0032] The compositions for improving or maintaining sleep quality of the present invention may label Garcinia indica and / or garcinol as the active ingredients, but are not limited to those labeled with Garcinia indica or garcinol as the active ingredients on the product packaging. For example, they may be products without a specific active ingredient. Furthermore, even general foods that are manufactured and sold with a suggested intended use are within the scope of the present invention. For example, foods sold with a website listing personal testimonials from people who have consumed the product, which mention the improvement or maintenance of sleep quality, are also within the scope of the present invention.

[0033] The composition of the present invention can be used as an oral composition for, for example, pharmaceuticals (including quasi-drugs) and so-called health foods, such as functional foods whose efficacy has been approved by a designated organization, such as foods for specified health uses, foods with nutrient functions, and foods with functional claims.

[0034] Examples of the composition of the present invention include tablets, capsules, powders, granules, liquids, granules, rods, plates, blocks, solids, pills, pastes, creams, caplets, gels, chewable tablets, and sticks. Among these, from the viewpoint of ease of administration, tablets, capsules, powders, granules, and liquids are preferred, and tablets, capsules, and granules are more preferred. Examples of oral compositions used as tablets, capsules, powders, granules, and liquids include supplements, food additives, packaged beverages filled in PET bottles, cans, bottles, etc., and powdered beverages to be dissolved in water (hot water), milk, fruit juice, etc.

[0035] The content of Garcinia indica in the composition of the present invention may be appropriately determined within the range that provides its effect. To obtain a higher effect, the content of Garcinia indica is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and particularly preferably 1.0% by mass or more, based on the solid content. Furthermore, from the viewpoint of ease of continuous oral intake in daily life, the content of Garcinia indica is preferably 90% by mass or less, more preferably 80% by mass or less, and particularly preferably 70% by mass or less, based on the solid content.

[0036] The content of garcinol in the composition of the present invention may be appropriately determined within the range that provides the desired effect. In order to obtain a higher effect, the content of garcinol in the solid content is preferably 0.0005% by mass or more, more preferably 0.005% by mass or more, and particularly preferably 0.05% by mass or more. In addition, in order to facilitate continuous oral intake in daily life, the content of garcinol in the solid content is preferably 60% by mass or less, more preferably 50% by mass or less, and particularly preferably 40% by mass or less.

[0037] Although there is no particular limitation on the amount of Garcinia indica to be taken in the present invention, in order to obtain a higher effect, the amount of Garcinia indica to be taken is preferably 5 mg or more per day, more preferably 25 mg or more, and particularly preferably 50 mg or more. Furthermore, in order to facilitate continuous oral intake in daily life, the amount of Garcinia indica to be taken in the present invention is preferably 5,000 mg or less per day, more preferably 1,000 mg or less, and particularly preferably 500 mg or less.

[0038] Although there is no particular limitation on the amount of garcinol intake in the present invention, in order to obtain a higher effect, the amount of garcinol intake is preferably 1 mg or more per day, more preferably 5 mg or more, and particularly preferably 10 mg or more. Furthermore, in order to facilitate continuous oral intake in daily life, the amount of Garcinia indica intake is preferably 1000 mg or less per day, more preferably 200 mg or less, and particularly preferably 100 mg or less.

[0039] The composition of the present invention may be designed so that the daily intake of Garcinia indica and / or garcinol is achieved without any particular limitation, and may be designed so that the above-mentioned intake amount is achieved in one dose or in multiple doses. That is, for example, the daily amount may be contained in a single container or in 2 to 4 separate containers.

[0040] The packaging form of the composition of the present invention is not particularly limited and can be appropriately selected depending on the dosage form, etc., and examples include blister packs such as PTPs; strip packaging; heat seals; aluminum pouches; film packaging using plastics, synthetic resins, etc.; glass containers such as vials; and plastic containers such as ampoules. [Example]

[0041] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples, and the present invention can take various forms as long as the object of the present invention can be achieved.

[0042] Test 1. Evaluation of antioxidant activity Tests were conducted to verify that the composition of the present invention has antioxidant activity. Antioxidation prevents damage to nerve cells caused by reactive enzyme species and protects the brain, which is expected to improve mood and sleep quality. Therefore, by evaluating the antioxidant activity, it is possible to evaluate the mood improving or maintaining effect and the sleep quality improving or maintaining effect.

[0043] (1) Test substance The following test substances were used: Garcinia indica (Example 1): Extract of Garcinia indica was used. The details are as follows: After drying the peel of Garcinia indica, it was extracted with ethanol. The resulting extract was filtered and concentrated to remove impurities. The concentrated extract was processed into powder to obtain powdered Garcinia indica extract. Garcinol (Example 2): A commercially available garcinol reagent was used. Garcinia cambogia (Comparative Example 1): A commercially available extract of Garcinia cambogia fruit was used. Hydroxycitric acid (Comparative Example 2): A commercially available hydroxycitric acid reagent was used. Cryptoxanthin (Comparative Example 3): A commercially available β-cryptoxanthin reagent was used. Ornithine (Comparative Example 4): A commercially available L-ornithine hydrochloride reagent was used. Ginseng (Comparative Example 5): A commercially available ginseng extract was used.

[0044] (2) Test method Test substances were prepared at 10 mg / mL in ultrapure water or DMSO. DPPH solution was prepared by dissolving 1-Diphenyl-2-picrylhydrazyl in 100% ethanol to 0.1 mM. 10 μL of test substance solution was added to a 1.5 mL tube. 10 μL of ultrapure water or DMSO was added to a 1.5 mL tube as a control. 1000 μL of 0.1 mM DPPH solution was added to each tube and incubated at room temperature for 20 minutes. After incubation, 300 μL of the reaction mixture was transferred to a 96-well plate, and the absorbance at 516 nm was measured using a plate reader. The inhibition rates compared to the solvent-based controls are shown in Table 1.

[0045] [Table 1]

[0046] <Test Results> As shown in the results in Table 1, Garcinia indica (Example 1) and garcinol (Example 2) showed superior antioxidant effects compared to Garcinia cambogia (Comparative Example 1), hydroxycitric acid (Comparative Example 2), cryptoxanthin (Comparative Example 3), ornithine (Comparative Example 4), ginseng (Comparative Example 5), and the control. Because Garcinia indica and garcinol exhibit superior antioxidant effects, they are expected to improve or maintain mood, as well as improve or maintain the quality of sleep.

[0047] Test 2: Evaluation of mood-enhancing or -maintaining effects, and sleep quality-enhancing or -maintaining effects In order to verify that the composition of the present invention has a mood improving or maintaining effect, and an effect of improving or maintaining the quality of sleep, a randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted in healthy adults.

[0048] (1) Test food The test food (Example 3) was a tableted food prepared by mixing the same Garcinia indica extract as in Study 1 with reduced maltose, cellulose, calcium stearate, and silicon dioxide. The control food (Comparative Example 6) was a food in which the Garcinia indica extract in the test food (Example 3) was replaced with caramel coloring and the amount of reduced maltose was adjusted to make it indistinguishable from the test food (Example 3) in appearance. Both the test food and control food were individually packaged in plain aluminum bags containing the recommended daily intake of two tablets (250 mg / tablet), ensuring blinding for the subjects and interventionists. The calorie and nutritional values ​​per recommended daily intake of the test food are shown in Table 2. The amount of garcinol contained in the test food (Example 3) was calculated to be 18.0 mg per recommended daily intake.

[0049] [Table 2]

[0050] (2) Subjects The subjects were 70 healthy adults (28 men and 42 women) aged 30 years or older and under 50 years old. Exclusion criteria for subject selection included the following: Those suffering from idiopathic chronic fatigue or chronic fatigue syndrome / Those suffering from a chronic disease and regularly taking medication / Those who are diagnosed with depression based on their CES-D score or medical interview / Those with a history of treatment for or a current history of sleep disorders / Those suffering from or currently undergoing treatment for serious liver disease, kidney disease, digestive disease, heart disease, respiratory disease, endocrine disease, thyroid disease, adrenal gland disease or other metabolic disease / Those using supplements, health foods or medications related to fatigue or lack of sleep / Those with a history of digestive disease or digestive surgery that affects digestion and absorption / Those who have a habit of drinking more than 20g of pure alcohol per day

[0051] (3) Test method This study was a 5-week randomized, double-blind, placebo-controlled, parallel-group comparative study (allocation ratio: 1:1), consisting of a pre-observation period (1 week) and an intake period (4 weeks). Participants were allocated using a block randomization method (block size: 4), with gender, age, and POMS2 (overall mood state (TMD) and "vigor-vitality" scores) as adjusting factors. A controller not directly involved in the study assigned the two groups to the test food group and the control food group. During the intake period, subjects were instructed to take one packet (2 tablets) of the test food (test food in the test food group, control food in the control food group) once a day with water or lukewarm water. Intake continued for 4 consecutive weeks.

[0052] (4) Inspection items The subjects were assessed twice, using the POMS2, SF-36, and OSA sleep questionnaire, and were interviewed by a doctor: a pre-intake test (hereafter referred to as "pre-intake") and a four-week post-intake test (hereafter referred to as "four-week post-intake"). POMS2 was administered to assess various mood and emotional states. Using the Japanese version of POMS2 (full adult version), standardized scores, or T-scores, were assessed for seven scales (anger-hostility, confusion-perplexity, depression-depression, fatigue-lethargy, tension-anxiety, vigor-vitality, and friendliness) for the past week, including today, as well as TMD. The SF-36 was used to assess health-related QOL. Using the Japanese version of the SF-36v2, scores were assessed based on national standard values ​​for eight items over the past month: physical functioning, role-based functioning (physical), bodily pain, general health, vitality, social functioning, role-based functioning (mental), and mental health. The OSA Sleep Questionnaire was administered upon waking to assess sleep status. Using the OSA Sleep Questionnaire (MA version), response scale values ​​(Zc scores) were assessed for five factors: "Factor 1: Sleepiness upon waking," "Factor 2: Falling asleep and maintaining sleep," "Factor 3: Dreaming," "Factor 4: Recovery from fatigue," and "Factor 5: Sleep duration." In addition, the subjects were given a food diary and a subject diary, and were asked to fill out the following survey items every day from one week before the start date of intake throughout the intake period. Survey items: (1) Test food intake status, (2) Changes in physical condition, (3) Changes in lifestyle, (4) Sleep duration, (5) Menstrual status, (6) Medication use, (7) Dietary content

[0053] (5) Statistical analysis The primary endpoint was the POMS2, and the secondary endpoints were the SF-36 and OSA Sleep Questionnaire. The analysis population was the PPS (Per-Protocol Set), and actual measured values ​​were compared between groups using the Mann-Whitney U test. The significance level for all tests was set at 0.05, and statistical analysis was performed using IBM SPSS Statistics 28. In addition, as basic statistics, subject background data were expressed as mean ± standard deviation (SD), and other data were expressed as mean ± standard error (SE).

[0054] <Test Results> (1) Subjects of analysis Each subject completed the test, and 13 subjects were excluded from the analysis due to changes in lifestyle, etc., leaving 57 subjects (21 men and 36 women) for analysis. The background of the subjects is shown in Table 3.

[0055] [Table 3]

[0056] (2) POMS2 As a result of POMS2, the T scores for each scale are shown in Table 4.

[0057] [Table 4]

[0058] As shown in Table 4, the test food group (Example 3) showed higher scores for the "vitality-vigor" and "friendship" categories compared to the control food group (Comparative Example 6). In particular, the intergroup comparison revealed that the "vitality-vigor" category of POMS2 after 4 weeks of intake was significantly higher in the test food group compared to the control food group (P<0.05). Furthermore, the test food group (Example 3) showed lower scores for the "anger-hostility," "confusion-bewilderment," "depression-depression," "fatigue-lethargy," "tension-anxiety," and "TMD" categories compared to the control food group (Comparative Example 6). In particular, the intergroup comparison revealed that the "TMD" and "fatigue-lethargy" categories of POMS2 after 4 weeks of intake were significantly lower in the test food group compared to the control food group (all P<0.05). The POMS2 results demonstrated that Garcinia indica has a mood-enhancing or mood-maintaining effect. Among its mood-enhancing or mood-maintaining effects, it was found to be particularly effective in reducing or maintaining a decrease in vitality and fatigue. Furthermore, from the results of Test 1, it is believed that the mood-enhancing or mood-maintaining effect is based on its antioxidant effect. Because garcinol has antioxidant effect and the test food (Example 3) contains garcinol, it is believed that garcinol is effective in improving or maintaining mood.

[0059] (3) SF-36 The SF-36 results, with scores for each scale, are shown in Table 5.

[0060] [Table 5]

[0061] As shown in Table 5, the test food group (Example 3) showed higher scores than the control food group (Comparative Example 6) in the categories of "Physical Function," "Daily Role Function (Physical)," "Overall Health Perception," "Vitality," "Social Function," "Daily Role Function (Mental)," and "Mental Health." In particular, the results of the between-group comparison showed significantly higher scores in the test food group than in the control food group for the SF-36 categories "Vitality," "Daily Role Function (Mental)," and "Mental Health" after 4 weeks of intake (P<0.05 for all). Furthermore, the test food group (Example 3) showed lower scores in the category of "Body Pain" compared to the control food group (Comparative Example 6). The SF-36 results indicated that Garcinia indica has a mood-enhancing or mood-maintaining effect. Among its mood-enhancing or mood-maintaining effects, it was particularly effective in reducing or maintaining a decline in vitality and energy, and in improving or maintaining mental health. Furthermore, the results of Study 1 suggest that the mood-enhancing or mood-maintaining effect is due to its antioxidant properties. Since garcinol has antioxidant properties and is contained in the test food (Example 3), garcinol is thought to be effective in improving or maintaining mood.

[0062] (4) OSA Sleep Questionnaire The results of the OSA sleep questionnaire are shown in Table 6.

[0063] [Table 6]

[0064] As shown in Table 6, the test food group (Example 3) showed higher scores than the control food group (Comparative Example 6) in each of the following categories: "Factor 1: Sleepiness upon waking," "Factor 2: Sleep onset and maintenance," "Factor 3: Dreaminess," "Factor 4: Fatigue recovery," and "Factor 5: Sleep duration." In particular, the results of the between-group comparison showed that "Factor 4: Fatigue recovery" on the OSA sleep questionnaire after 4 weeks of intake was significantly higher in the test food group than in the control food group (P<0.05). The results of the OSA sleep questionnaire demonstrated that Garcinia indica has the effect of improving or maintaining sleep quality. Among its effects in improving or maintaining sleep quality, its effectiveness in reducing or maintaining fatigue upon waking was particularly strong. Furthermore, the results of Study 1 suggest that the effect of improving or maintaining sleep quality is due to its antioxidant properties. Given that garcinol has antioxidant properties and that the test food (Example 3) contains garcinol, it is believed to be effective in improving or maintaining mood.

[0065] These results suggest that Garcinia indica has mood-enhancing and sleep-maintaining effects, and that garcinol is effective in improving and maintaining mood and sleep quality.

[0066] <Production example> Based on the results of the Examples, the following Production Examples of the present invention are given below.

[0067] [Production Example 1-4: Granules] According to the formulation in Table 7, Garcinia indica was mixed with other ingredients and then fluidized bed granulation was performed using a granulator to produce the granules described in Manufacturing Examples 1-4. The granules described in Manufacturing Examples 1-4 can be taken by dissolving 3 g per day in 100 ml of water, or they can be taken as is without dissolving. All of the granules in Manufacturing Examples 1-4 are effective in improving or maintaining mood, as well as improving or maintaining the quality of sleep.

[0068] [Table 7]

[0069] [Manufacturing Example 5-8: Tablets] According to the formulation in Table 8, Garcinia indica was mixed with other ingredients and then compressed using a rotary tablet press to produce tablets (250 mg) of Preparation Examples 5-8. One to two tablets of Preparation Examples 5-8 can be taken daily with water. All tablets of Preparation Examples 5-8 are effective in improving or maintaining mood, as well as improving or maintaining the quality of sleep.

[0070] [Table 8]

[0071] [Manufacturing Example 9-12: Hard Capsules] According to the formulation in Table 9, Garcinia indica was mixed with other ingredients and coated with a film containing gelatin or hydroxypropyl cellulose to produce hard capsules (contents: 300 mg). One to two capsules can be taken daily with water. All hard capsules in Manufacturing Examples 9-12 are effective in improving or maintaining mood, as well as improving or maintaining sleep quality.

[0072] [Table 9] [Industrial Applicability]

[0073] The composition of the present invention is industrially useful because it can improve or maintain mood and improve or maintain the quality of sleep and can be used as a health food or the like.

Claims

1. A mood enhancing or maintaining composition comprising Garcinia indica.

2. A mood enhancing or maintaining composition comprising garcinol.

3. 3. The composition for improving or maintaining mood according to claim 1 or 2, wherein the mood improvement or maintenance is at least one selected from the reduction or maintenance of decreased vitality and energy, the reduction or maintenance of fatigue, the reduction or maintenance of irritability, the reduction or maintenance of confusion, the reduction or maintenance of depression, the reduction or maintenance of anxiety, the improvement or maintenance of mental health, the reduction or maintenance of stress, and the improvement or maintenance of motivation.

4. A composition for improving or maintaining sleep quality, characterized by containing Garcinia indica.

5. A composition for improving or maintaining sleep quality, comprising garcinol.

6. 6. The composition for improving or maintaining sleep quality according to claim 4 or 5, wherein the improvement or maintenance of sleep quality is at least one selected from reducing or maintaining sleepiness upon waking, promoting or maintaining sleep onset, increasing or maintaining sleep time, reducing or maintaining dreaminess, reducing or maintaining fatigue upon waking, shortening or maintaining the time spent awake during the night, and improving or maintaining satisfaction with sleep.

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