Shampoo veterinary compositions

Abstract

To provide shampoo compositions which are effective in terms of washing, which make it possible to preserve, or indeed improve, the barrier function of the skin and of the coat and / or the silky appearance of the coat, which make it possible to preserve the bacterial flora which is beneficial to the mammals, while limiting, or indeed preventing, the colonization of the skin by pathogenic bacteria.SOLUTION: The present invention provides a veterinary composition of shampoo type, comprising an active ingredient obtained from Ophiopogon japonicus, and at least one amphoteric surfactant selected from betaines.SELECTED DRAWING: None

Description

[Technical Field]

[0001] Object of the invention The present invention relates to the veterinary field, more particularly to a shampoo composition intended for non-human mammals, comprising an active ingredient obtained from Ophiopogon and an amphoteric surfactant, and also to a method for cleaning the coat of a non-human mammal by applying the shampoo composition to the coat and / or skin. Technical Field

[0002] An active ingredient obtained from Ophiopogon and its moisturizing effect or its effect of strengthening the barrier function of human skin are described in patent EP 2271311. The use of said active ingredient for the treatment of atopic dermatitis in animals and humans is described in patent application WO 2017 / 121965.

[0003] However, there is no mention of the shampoo containing this active ingredient that is suitable for non-human mammals, specifically dogs and cats.The skin and coat of non-human mammals protect these mammals from external attack.Therefore, their maintenance is very important for the well-being and actually health of non-human mammals.The skin and hair of domestic animals such as dogs and cats are covered with a layer of fatty acid and wax, which contributes to barrier function, and therefore plays a role in protecting skin from external attack and gives coat a silky appearance.

[0004] Therefore, a veterinary shampoo must be effective in terms of cleansing power for the skin and coat without causing irritation or any other skin damage. It must also therefore preserve or maintain the barrier function and / or silky appearance of the coat. Specifically, the skin must maintain its protective effect against external aggressions.

[0005] Furthermore, dogs and / or cats are home to bacteria that can be pathogenic or can become pathogenic if overgrown, such as staphylococcaceae, which require special treatment to consider their reduction or elimination. These staphylococcaceae are mainly represented by S. pseudontermedius.

[0006] There is therefore a need for a shampoo composition for non-human mammals, in particular for dogs and cats, which is effective in terms of cleaning, which makes it possible to preserve or indeed improve the barrier function of the skin and coat and / or the silky appearance of the coat, and which makes it possible to preserve a bacterial flora that is beneficial to the mammal, while at the same time limiting or indeed preventing colonization of the skin by pathogenic bacteria. Summary of the Invention

[0007] In this context, the Applicant proposes a novel shampoo composition comprising an active ingredient obtained from Ophiopogon and at least one amphoteric surfactant chosen from the betaines.

[0008] The present invention therefore relates to a veterinary composition intended to be used as a shampoo for non-human mammals, in particular dogs or cats, comprising an active ingredient obtained from Ophiopogon and at least one amphoteric surfactant selected from betaines.

[0009] It is therefore a further object of the present invention to provide a method for treating the skin of a non-human mammal, in particular a dog or cat, by applying a composition of the present invention to the skin and / or coat of said mammal. The present invention relates to a method for cleansing and / or washing the skin and / or coat.

[0010] A further object of the present invention relates to the use of a composition as defined in the present application, or a method of using said composition, for reducing and / or preventing the presence of pathogenic bacteria and / or the formation and / or adhesion of pathogenic bacterial biofilms in the case of non-human mammals, such as dogs or cats. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention as described in this application relates to a veterinary composition for shampoos comprising an active ingredient obtained from Ophiopogon and at least one amphoteric surfactant selected from betaines.

[0012] Ophiopogon is a perennial, low, abundant, rhizomatous herbaceous plant of the lily family. It is cultivated as an ornamental cover plant with a tuberous rhizome and has numerous uses in traditional Chinese medicine.

[0013] This species is native to Japan and Korea, and is also cultivated in Vietnam and China, specifically in Sichuan, Zhejiang, and Hubei provinces. It is also known as "Muguet du Japon" in France and "Mondo grass," "Fountain plant," "Monkey grass," or "Dwarf lilyturf" in English. The tuberous roots are several centimeters long, pale yellow to yellowish-brown in color, and wrinkled longitudinally. They have a faint odor and a slightly sweet, mucilaginous taste.

[0014] In traditional Chinese medicine, the root is known to "nourish the lungs and yin, nourish the stomach, generate fluids, remove heat from the heart, and calm the spirit." Its main therapeutic indications, according to the 16th edition of the Japanese Pharmacopoeia, are dry cough, sore throat, insomnia, irritability, constipation, and diphtheria.

[0015] Ophiopogon roots are derived from plants cultivated in China and Vietnam. Ophiopogon extracts are known as skin cosmetics, specifically in patent EP2271311, as moisturizing agents by affecting the NMF (natural moisturizing factor) ratio and the formation of tight junctions in the skin layers. Application WO2017 / 121965 also describes that Ophiopogon extracts can be used to treat atopic dermatitis.

[0016] In the sense of the present invention, "active agent" or "active ingredient" or "extract" means at least one molecule, preferably a set of molecules, that has an effect on the cells of the skin.

[0017] In the sense of the present invention, "active agent obtained from Ophiopogon" means any molecule or mixture of molecules obtained from Ophiopogon. They may be natural molecules of the plant or molecules obtained by any kind of transformation of natural molecules of the plant, for example by hydrolysis. The active agent according to the present invention is preferably a hydrolysate.

[0018] "Hydrolysate" means any extract from Ophiopogon obtained by a process comprising at least one step of enzymatic or chemical hydrolysis of Ophiopogon, preferably at least one step of enzymatic hydrolysis. "Ophiopogon" means the whole or part of the plant. It can be the whole plant or a part of the plant. It is preferably the tuber of Ophiopogon.

[0019] "Oligosaccharide" means an oligomer formed from many monosaccharide units linked by glycosidic bonds, the number of monosaccharide units being less than 25. "Polysaccharide" means a polysaccharide formed from many monosaccharide units linked by glycosidic bonds. It refers to a polymer formed from interconnected simple sugars, with more than 25 monosaccharide units.

[0020] The active agent obtained from Ophiopogon sieboldii used in the composition according to the present invention is preferably an active agent obtained from Ophiopogon sieboldii containing sugars. Even more preferably, it contains fructosan, more specifically, it contains at least 57% by weight, and even more preferably at least 80% by weight, of fructosan, based on the total weight of the sugars in the active agent. Fructosans are polysaccharides composed of fructose and glucose. The sugars containing the active agent preferably consist of 45-80% fructose, 20-50% glucose, and 0-5% galactose. The sugars can be in the form of monomers, oligomers, and polymers. The sugars contained in the active agent are predominantly oligosaccharides and polysaccharides with a molecular weight of less than 400 kDa in the form of fructosan. Thus, the active agent according to the present invention preferably contains oligosaccharides and polysaccharides with a molecular weight of less than 400 kDa in the form of fructosan, representing at least 57% by weight of the sugars present in the active agent. According to a particularly preferred variant, the active agent is obtained from the tubers of Ophiopogon.

[0021] According to one embodiment, the active agent used to prepare the composition according to the invention is present in the form of a powder, in particular a transparent colored powder, having the following characteristics: -Amount of dry matter between 900 and 1000 mg / g, or - a sugar content of 500 to 800 mg / g, ie at least 50% by weight of sugars relative to the weight of dry matter,

[0022] The amount of dry matter can be measured by passing a sample through a sterilizer at 105°C until a constant weight is obtained.

[0023] The overall sugar content can be determined by the DUBOIS method based on the range of fructose (Dubois M. et al., Analytical Chemistry, 28, 3, 350-356, 1956).

[0024] Characterization of the molar mass of carbohydrates present in the active agents of the present invention can be achieved by HPLC methods and by quantitation of simple sugars by ionic liquid chromatography.

[0025] The molar mass of the carbohydrate is estimated by comparing the retention time of the peak detected in the active agent sample with the retention time of a pre-injected standard.

[0026] The operating conditions are preferably as follows: - Instrument: Agilent 1100 Series HPLC -Column: PL Aquagel-OH C60, C40, C30 columns with the same pre-column characteristics -Elution mode: Isocratic -Mobile phase: Buffer NaN030.3M+NaH2P04-2H20 0.01M pH7 -Detection wavelength: UV 254nm and 280nm

[0027] The active agent according to the present invention is preferably an active agent obtained from the tubers of Ophiopogon in an aqueous medium. "Obtained in an aqueous medium" means a medium containing mainly water, or a basic or acidic aqueous medium. Specifically, it is not an oil or essential oil.

[0028] The active agent according to the present invention is preferably a hydrolysate, preferably an enzymatic hydrolysate, of Ophiopogon.

[0029] According to a particularly preferred variant, the active agent according to the invention is a hydrolysate of Ophiopogon, preferably an enzymatic hydrolysate of Ophiopogon tubers.

[0030] Specifically, the active agent that can be used according to the present invention can be obtained by carrying out the following steps. solubilization of powder of Ophiopogon (preferably tubers) in water at a rate of at least 50 g / l; - enzymatic hydrolysis of at least one sugar, Separation of soluble and insoluble phases, for example by sedimentation, -Enzymatic inactivation by heat treatment of the soluble phase.

[0031] Following enzymatic inactivation, one or more steps of filtration and / or concentration may be carried out. The active agent may be obtained in liquid or powder form by spraying or freeze-drying. It is preferably sprayed in the presence of a spray additive of maltodextrin type and used in powder form.

[0032] In order to obtain an active agent having the characteristics of the present invention, specifically the presence of fructosans having a molecular weight of less than 400 kDa, various process parameters must be adjusted.

[0033] According to a preferred embodiment, the active agent is atomized using maltodextrin and is therefore present in powder form (before incorporation into the composition according to the invention).

[0034] The composition according to the invention advantageously comprises at least 0.1% by weight, preferably 0.1 to 1% by weight (or 0.1 to 0.8% by weight), more particularly 0.1 to 0.6% by weight, of the active ingredient obtained from Ophiopogon according to the invention, relative to the total weight of the composition.

[0035] The betaine-type amphoteric surfactants are preferably selected from alkyl (C8-C20) betaines, alkyl (C8-C20) amidoalkyl (C1-C8) betaines, alkyl (C8-C20) amidoalkyl (C1-C8) sulfobetaines, alkyl (C8-C20) amidoalkyl (C1-C6) hydroxysulfobetaines, sulfobetaines, and hydroxysulfobetaines. By way of example, mention may be made, individually or in mixtures, of compounds classified under the names cocobetaine, lauryl betaine, cetyl betaine, coco / oleamidopropyl betaine, cocamidopropyl betaine, palmitamidopropyl betaine, stearamidopropyl betaine, cocamidoethyl betaine, cocamidopropyl hydroxysultaine, oleamidopropyl hydroxysultaine, cocohydroxysultaine, lauryl hydroxysultaine, and cocosultaine.

[0036] In particular, the at least one amphoteric surfactant of betaine type is selected from alkyl(C8-C20)amidoalkyl(C1-C6)betaines, alkyl(C8-C20)amidoalkyl(C1-C6)sulfobetaines (also called alkyl(C8-C20)amidoalkyl(C1-C6)sultaines), and alkyl(C8-C20)amidoalkyl(C1-C6)hydroxysulfobetaines (also called alkyl(C8-C20)amidoalkyl(C1-C6)hydroxysultaines). The amphoteric surfactant of betaine type is preferably selected from alkyl(C8-C20)amidoalkyl(C1-C6)hydroxysultaines. It is more particularly cocamidopropylhydroxysultaine (sold in particular by Seppic under the trade name "Amonyl 675 SB").

[0037] The composition according to the invention advantageously comprises at least 3% by weight of amphoteric surfactant of betaine type relative to the total weight of the composition, preferably between 4 and 15% by weight, and more particularly between 4 and 12% by weight relative to the total weight of the composition.

[0038] As used herein, the term "shampoo" includes any composition intended to cleanse the hair or skin of a non-human mammal and requires rinsing with water after application to the non-human mammal. Generally, shampoos have certain essential properties. Thus, shampoos have wetting, foaming, and detergent properties to ensure satisfactory cleansing of the skin and coat.

[0039] Specifically, shampoo compositions according to the invention contain, in addition to the at least one amphoteric surfactant selected from betaines, one or more additional surfactants, preferably at least one additional anionic, cationic, amphoteric, nonionic surfactant, or mixtures thereof. According to a preferred embodiment, shampoo compositions according to the invention contain, in addition to the at least one amphoteric surfactant selected from betaines, at least one additional anionic surfactant, at least one additional amphoteric surfactant (i.e., different from the at least one amphoteric surfactant selected from betaines), at least one additional nonionic surfactant, or mixtures thereof.

[0040] Of the anionic surfactants, sulfonic acid or carboxylic acid anionic surfactants are preferably used.

[0041] According to the present invention, sulfonic acid anionic surfactants have at least one sulfonic acid functional group (-SO3H or -SO3 - ) and is an anionic surfactant that does not have a cationic functional group.

[0042] Sulfonic acid anionic surfactants that can be used in the context of the present invention, either alone or in mixtures, are salts (particularly alkali salts, particularly sodium, ammonium, amine, amino alcohol, or magnesium salts), alkyl sulfonates, alkyl sulfosuccinates, alkyl ether sulfosuccinates, acyl isethionates, acyl methyl isethionates, and methyl acyltaurates, in which the alkyl or acyl radical of all these different compounds preferably contains 8 to 24 carbon atoms, and the aryl radical preferably represents a phenyl or benzyl group. The average number of ethylene oxide or propylene oxide groups can be particularly 2 to 50, more particularly 2 to 10.

[0043] According to the present invention, a carboxylic acid anionic surfactant is an anionic surfactant having at least one carboxylic acid functional group (-COOH), optionally in the form of a salt (-COO - ) form.

[0044] The carboxylic acid type anionic surfactant, which is different from the surfactant, preferably does not have a sulfate or sulfonate functional group and may be selected from alkyl D-galactosiduronic acids and their salts, alkyl (C6-C24) ether carboxylic acid polyoxyalkylene acids, alkyl (C6-C24) aryl ether carboxylic acid polyoxyalkylene acids and their salts, alkyl (C6-C24) amide ether carboxylic acid polyoxyalkylene acids and their salts, specifically those containing 2 to 50 alkylene, specifically ethylene, oxide groups, such as the compound proposed by KAO under the name AKYPO, acyl (C6-C24) sarcosinates and their salts, acyl (C6-C24) lactylates and their salts, and acyl (C6-C24) glutamates. Also, alkyl glucosides acetate, alkyl glucosides citrate, and alkyl polyglycol tartrate. It is also possible to use esters of alkyl carboxylate (C6-C24) polyglycosides, such as glycosides, which are sold, in particular, by Lamberti under the names Eucarol APG / EC and Eucarol APG / ET, and by Cognis under the name Plantapon LGC SORB.

[0045] The salts are particularly chosen from alkali salts, particularly sodium, ammonium salts, amine salts, amino alcohol salts such as triethanolamine or monoethanolamine, and magnesium salts.

[0046] Alkyl (C6-C24) ether carboxylic acid polyoxyalkylene acids and their salts, alkyl (C6-C24) amide ether carboxylic acid polyoxyalkylene acids and their salts, specifically those containing 2 to 15 alkylene oxide groups, alkyl (C6-C24) polyglycoside carboxylic acid esters and their salts, and acyl (C6-C24) glutamates and their salts, and mixtures thereof are preferably used. More specifically, alkyl (C6-C24) ether carboxylic acid polyoxyalkylene acids and their salts, alkyl (C6-C24) amide ether carboxylic acid polyoxyalkylene acids, specifically those containing 2 to 15 alkylene oxide groups and their salts, and mixtures thereof are more particularly used.

[0047] Among these anionic surfactants, surfactants that do not contain sulfate are preferably used.According to a specific embodiment, the composition according to the present invention comprises at least one anionic surfactant selected from alkyl ether sulfosuccinate, acyl methyl isethionate, and methyl acyltaurate.Specifically, the composition according to the present invention uses disodium laureth sulfosuccinate, sodium lauroyl methyl isethionate, sodium methyl cocoyl taurate, or their mixture.

[0048] The anionic surfactant may be present in an amount of from 2% to 30% by weight, preferably from 4% to 25% by weight, particularly from 6% to 20% by weight, more particularly from 8% to 15% by weight, and best from 10% to 14% by weight, relative to the total weight of the composition.

[0049] More particularly, the composition comprises disodium laureth sulfosuccinate, in particular marketed by the company Evonik under the trade name Rewopol SB 30 B. The amount of disodium laureth sulfosuccinate may be 1 to 5% by weight, preferably 2 to 4% by weight, relative to the total weight of the composition.

[0050] More particularly, the composition comprises sodium lauroyl methyl isethionate (particularly sold under the trade name Iselux Flakes by the company Innospec), which may represent 3 to 7% by weight, preferably 4 to 5% by weight, relative to the total weight of the composition.

[0051] More specifically, the composition comprises sodium methyl cocoyl taurate (particularly sold under the trade name Pureact WS Conc. by Innospec Inc.), the amount of sodium methyl cocoyl taurate may be 3-7% by weight, preferably 4-5% by weight, relative to the total weight of the composition.

[0052] Specifically, the composition comprises a mixture of disodium laureth sulfosuccinate, sodium lauroyl methyl isethionate, and sodium methyl cocoyl taurate, according to the amounts of each as set forth above.

[0053] Additional amphoteric surfactants other than those of the betaine type that can be used in the present invention are in particular: In a non-limiting list, the aliphatic radicals may be secondary or tertiary aliphatic amines, where the aliphatic radical is straight or branched chain containing 8 to 22 carbon atoms and at least one anionic water-solubilizing group (e.g., carboxylic acid, sulfonic acid, sulfate, phosphate, or phosphonic acid group).

[0054] These compounds may be the following compounds: sodium cocoamphoacetate, sodium cocoyl glutamate, disodium cocoamphodiacetate, disodium lauroamphodiacetate, disodium caprylamphodiacetate, disodium capryloamphodiacetate, disodium cocoamphodipropionate, disodium lauroamphodipropionate, disodium caprylamphodipropionate, disodium capryloamphodipropionate, lauroamphodipropionic acid, cocoamphodipropionic acid (INCI name). The amphoteric surfactants in addition to those of the betaine type are preferably selected from sodium cocoamphoacetate, sodium cocoyl glutamate, and mixtures thereof.

[0055] The additional amphoteric surfactants other than those of the betaine type, in particular sodium cocoamphoacetate and / or sodium cocoyl glutamate, are present in the compositions according to the invention in an amount ranging from 0.1 to 10% by weight, preferably from 1 to 5% by weight, more particularly from 2 to 4% by weight, and best from 2 to 3% by weight, relative to the total weight of the composition.

[0056] Nonionic surfactants that may be associated with these compounds and compositions include, in particular, alkyl glucosides, alkyl polyglucosides, derivatives of castor oil, polysorbates, copramides, N-alkylamines, or amine oxides.

[0057] According to a particular embodiment, the composition according to the invention comprises at least one nonionic surfactant selected from alkyl (poly)glucosides, in particular decyl glucoside, lauryl glucoside, cocoyl glucoside, or capryl / caprylyl polyglucosides. The composition according to the invention preferably comprises decyl glucoside.

[0058] The nonionic surfactant may be present in the composition according to the invention in an amount of from 0.1 to 15% by weight, preferably from about 1 to 10% by weight, more preferably from about 3 to 8% by weight, and best from 5 to 7% by weight, relative to the total weight of the composition.

[0059] The composition is preferably an aqueous composition, which may contain water in an amount of 30 to 95% by weight, preferably 40 to 90% by weight, and particularly 50 to 85% by weight, relative to the total weight of the composition.

[0060] The composition according to the present invention may contain other compounds, such as modified or unmodified guar gum. More specifically, the composition according to the present invention contains cationic galactomannan gum (which is more specifically described in US Patents Nos. 3,589,578 and 4,031,307). Guar gum containing cationic trialkylammonium groups may be used. For example, guar gum modified with a salt (e.g., chloride) of 2,3-epoxypropyltrimethylammonium may be used. Such a product is, in particular, sold under the name JAGUAR EXCEL by Solvay or SACI-CFPA. The modified or unmodified guar gum is advantageously present in the composition in an amount of 0.01 to 0.5% by weight, preferably 0.05 to 0.15% by weight, and best 0.08 to 0.1% by weight, based on the total weight of the composition.

[0061] The composition according to the present invention specifically contains EDTA (ethylenediaminetetraacetic acid) and its salts, such as disodium EDTA and dipotassium EDTA, sodium metaphosphate, The composition may comprise one or more chelating agents which may be selected from phosphate compounds such as sodium hexametaphosphate, tetrapotassium pyrophosphate, and the like, phosphonic acids and their salts, such as salts of ethylenediaminetetra(methylenephosphonic acid), and mixtures thereof.

[0062] The shampoo composition according to the present invention may further comprise agents beneficial to the skin or coat.These ingredients are generally incorporated into the composition to improve the tactile quality of the keratinous fibers of the coat or skin, or indeed to promote their hydration.Emollients such as cationic polymers, silicones, and polyols constitute the most commonly used ingredients in this context.It is also possible to use soothing agents such as panthenol.

[0063] The composition may also contain thickening or suspending agents, such as copolymers of acrylic or methacrylic acid with branched alkyl acrylates and chains of allyl ethers of pentaerythritol or saccharose. In particular, the compound Acrylate / C10-30 Alkyl Acrylate Crosspolymer (INCI name) may be cited.

[0064] The compositions according to the invention may further comprise other compounds chosen in particular from sugars, oligosaccharides, hydrolyzed or non-hydrolyzed polysaccharides, modified or unmodified, for example isomerized sugars, amino acids, oligopeptides, peptides, hydrolyzed or non-hydrolyzed proteins, modified or unmodified, branched or unbranched fatty acids and alcohols, animal, vegetable or mineral oils or waxes, ceramides and pseudoceramides, hydroxylated organic acids, antioxidants, anti-free radical agents, cationic, anionic or non-ionic polymers, soluble or dispersible, or mixtures of said compounds.

[0065] Of course, a person skilled in the art will certainly select this or these possible additional compounds and / or their amounts in such a way that the advantageous properties inherently related to the association according to the invention are not altered or substantially not altered by the intended addition.

[0066] The additives are optionally present in the composition according to the invention in a proportion that may range from 0.00001 to 30% by weight, relative to the total weight of the composition. The exact amount of each additive can be easily determined by those skilled in the art, depending on its type and function.

[0067] Advantageously, the composition according to the invention may contain one or more agents beneficial to the skin or integument, in particular hydrating agents selected from, for example, panthenol, high-fructose corn syrup, and / or glycerin. Panthenol may be present in the composition in a content of 0.1 to 3% by weight relative to the total weight of the composition. High-fructose corn syrup may be present in the composition in a content of 0.001 to 1% by weight relative to the total weight of the composition.

[0068] These shampoo compositions may be provided in the form of thicker or thinner liquids, and they are primarily suitable for cleaning and caring for keratinous materials, in particular the coat or skin of non-human mammals.

[0069] The present invention relates to a method for cleansing and / or washing the skin and / or coat of a non-human mammal, in particular a dog or cat, by applying a composition of the present invention to the skin and / or coat of said mammal.

[0070] The composition according to the invention is carried out by simple application to the non-human mammal, optionally after wetting all or part of the non-human mammal with water, optionally massaging or rubbing with the hands to generate a lather, which is then removed by rinsing with water after an optional dwell time, and this operation can be repeated one or more times.

[0071] The present invention also relates to a method for cleansing and conditioning the coat and / or skin of a non-human mammal, comprising applying a composition as defined above and then, after a possible residence time, rinsing with water. The skin and / or coat is advantageously moistened before applying the composition according to the invention.

[0072] The method according to the invention also makes it possible to be non-irritating or actually reduce skin irritation, which reduces stress and provides a well-being effect to non-human mammals, in particular dogs or cats, and in particular to preserve or actually improve the barrier function of the skin, by reducing irritation and / or by providing a silky appearance to the coat.

[0073] The shampoo compositions according to the present invention for non-human mammals, particularly dogs and cats, allow for effective cleaning while preserving or even improving the barrier function of the skin and / or coat and / or the silky appearance of the coat. The shampoo compositions according to the present invention for non-human mammals, particularly dogs and cats, also allow for reducing the presence or occurrence of pathogenic bacteria, or reducing and / or preventing the formation and / or adhesion of pathogenic bacterial biofilms, particularly Staphylococcus aureus and / or Staphylococcus pseudintermedius.

[0074] A further object of the present invention relates to the use of a composition as defined above or a method of using said composition for reducing and / or preventing the formation and / or adhesion of pathogenic bacterial biofilms or for reducing the presence of pathogenic bacteria such as Staphylococcus aureus and / or Staphylococcus pseudintermedius on the skin or coat in non-human mammals, in particular dogs or cats.

[0075] Thus, the use of a composition as defined above or a method of using said composition for reducing and / or preventing the formation and / or adhesion of pathogenic bacterial biofilms or for reducing the presence of pathogenic bacteria can be achieved by application of a composition as defined above, followed by rinsing with water after an optional dwell time. The skin and / or coat are advantageously moistened before application of the composition according to the invention.

[0076] According to a particular embodiment of the invention, the non-human mammal is selected from the family Feline, Canine, and / or Equine, in particular dogs and cats.

[0077] The term "approximately" is understood by those skilled in the art and may vary to some extent depending on the context in which it is used. Depending on the context, if some uses of the term are not clear to those skilled in the art, "approximately" means plus / minus 10%, preferably plus / minus 5% of the indicated value.

[0078] Values ​​given in intervals specified in the text are always inclusive unless otherwise stated.

[0079] According to the present invention, the term "comprises" or "comprise" (and other equivalent terms, e.g., "containing" and "including") is "open-ended" and can be interpreted in a general manner to include the specified features mentioned as well as all optional, additional, and non-specified features. According to certain embodiments, it also applies to the expression "consisting essentially of," or the specific features including the specified features and optional, additional, or non-specified features that do not materially affect the basic and novel feature(s) of the claimed invention, unless otherwise indicated. can be interpreted as "consisting of" including only the features of

[0080] According to the present invention, the term "at least" means "one," "two," "three," or more.

[0081] Other aspects and advantages of the invention will appear from reading the following examples, which should be considered as illustrative and non-limiting.

[0082] Percentages given are by weight unless otherwise stated. [Example]

[0083] The following compositions in Tables 1-4 are prepared according to conventional methods for preparing shampoos.

[0084] These compositions exhibit good cleaning properties. They improve the barrier function, restore microbial balance, and reduce the presence of pathogenic bacteria, particularly Staphylococcus aureus and / or Staphylococcus pseudintermedius, in dogs and cats, and limit the adhesion or formation of biofilms. Pathogenic bacteria are particularly Staphylococcus aureus and / or Staphylococcus pseudintermedius. [Table 1] [Table 2] [Table 3] [Table 4]

Claims

1. A shampoo-type veterinary composition comprising an active ingredient obtained from Ophiopogon and at least one amphoteric surfactant selected from betaines.

2. 2. The veterinary composition of claim 1, comprising at least 0.1% by weight, preferably 0.1 to 1% by weight, more particularly 0.1 to 0.6% by weight, of an active ingredient obtained from Ophiopogon sieboldii relative to the total weight of the composition.

3. 3. A veterinary composition according to claim 1 or 2, wherein said at least one amphoteric surfactant of the betaine type is selected from alkyl(C8-C20)amidoalkyl(C1-C6)betaines, alkyl(C8-C20)amidoalkyl(C1-C6)sulfobetaines, alkyl(C8-C20)amidoalkyl(C1-C6)hydroxysulfobetaines.

4. 4. A veterinary composition according to any one of claims 1 to 3, comprising at least 3% by weight of said betaine type amphoteric surfactant relative to the total weight of the composition, preferably from 4 to 15% by weight, more particularly from 4 to 12% by weight relative to the total weight of the composition.

5. 10. A veterinary composition according to any one of the preceding claims, which contains, in addition to said at least one amphoteric surfactant selected from said betaine, at least one anionic surfactant, at least one additional amphoteric surfactant, at least one non-ionic surfactant, or mixtures thereof.

6. 6. The veterinary composition of claim 5, wherein the anionic surfactant is selected from disodium laureth sulfosuccinate, sodium lauroyl methyl isethionate, sodium methyl cocoyl taurate, or mixtures thereof.

7. 7. The veterinary composition of claim 5 or 6, wherein the additional amphoteric surfactant in addition to the betaine type is selected from sodium cocoamphoacetate, sodium cocoyl glutamate, and mixtures thereof.

8. 8. A veterinary composition according to any one of claims 5 to 7, wherein the additional amphoteric surfactant in addition to the betaine type is present in an amount of 0.1 to 10% by weight, preferably 1 to 5% by weight, more particularly 2 to 4% by weight, best 2 to 3% by weight, relative to the total weight of the composition.

9. 9. The veterinary composition according to any one of claims 5 to 8, wherein the composition comprises at least one non-ionic surfactant selected from alkyl (poly)glucosides, in particular decyl glucoside, lauryl glucoside, cocoyl glucoside, capryl / caprylyl polyglucosides, or mixtures thereof.

10. 10. A veterinary composition according to any one of claims 5 to 9, wherein the non-ionic surfactant is present in the composition in an amount of 0.1 to 15%, preferably 1 to 10%, more particularly 3 to 8%, best 5 to 7% by weight relative to the total weight of the composition.

11. A veterinary composition according to any preceding claim, wherein the composition further comprises a cationic galactomannan gum.

12. The composition according to any one of claims 1 to 11 is applied to the skin and / or coat of a non-human mammal, in particular a dog or a cat, to thereby improve the condition of the non-human mammal. A method for cleansing and / or washing the skin and / or said coat.

13. 13. The method of claim 12, wherein the method comprises optionally wetting all or part of the non-human mammal with water before applying to the non-human mammal, and wherein a lather generated, optionally by massaging or rubbing using hands, is then removed by rinsing with water after an optional dwell time.

14. 12. A method for reducing and / or preventing the formation and / or adhesion of pathogenic bacterial biofilms or for reducing the presence of pathogenic bacteria on the skin and / or coat in a non-human mammal, in particular a dog or a cat, by using a veterinary composition according to any one of claims 1 to 11.

15. 15. The method according to claim 14, characterized in that the pathogenic bacteria are selected from Staphylococcus aureus and / or Staphylococcus pseudointermedius.

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