Breast cancer detection kit or device and detection method

Abstract

To provide breast cancer detection kits or devices and detection methods.SOLUTION: Provided is a breast cancer detection kit or device comprising nucleic acids capable of specifically binding to miRNA in a subject's sample, and methods for detecting breast cancer, comprising measuring the miRNA in vitro.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a specific m A kit or device for detecting breast cancer, which comprises a nucleic acid capable of specifically binding to iRNA, and the The present invention relates to a method for detecting breast cancer, which comprises measuring the expression level of the miRNA using nucleic acids. [Background technology]

[0002] The breast consists of the mammary glands that produce breast milk, the lobules that separate from the mammary glands, the milk ducts that separate from the lobules and carry milk. Approximately 90% of breast cancers originate in the milk ducts. Approximately 5-10% of tumors originate from the lobule (Non-Patent Document 1). Cancer deaths by site in Japan in 2011, as disclosed by the Cancer Control Information Center According to statistics, the number of deaths from breast cancer reached 12,731, which means that one in 14 Japanese women It is the most common cancer site in women, with 8% of cases occurring in the United States. It is said that one in every 10 women will develop breast cancer, and the estimated number of women affected by breast cancer in 2014 was The number of cases is estimated to be as high as 232,670, of which approximately 40,000 will die (Non-Patent Reference 1).

[0003] The progression of breast cancer is defined in Non-Patent Document 2 and is based on tumor size, invasiveness, lymph node metastasis, etc. Stages 0, IA, IB, IIA, IIB, IIIA, III, and III are determined by the type of cancer, including distant metastasis. The five-year relative survival rate for breast cancer is largely dependent on the stage of the cancer. However, the rate was 100% in stages 0 and 1, 93% in stage 2, and 7% in stage 3. The incidence rate for stage 2 breast cancer is reported to be 2% and for stage 4 breast cancer is reported to be 22% (Non-Patent Document 1). Early detection leads to improved survival rates, so providing tools that enable early detection is essential. It is highly desired.

[0004] In principle, breast cancer is treated surgically, but depending on the stage of progression, metastasis, overall condition, and classification of breast cancer, In particular, in the case of early stage 1 or 2 breast cancer, In some cases, breast-conserving therapy can be selected in combination with radiation therapy (Non-Patent Document 1).

[0005] According to Non-Patent Document 1, the primary examination for breast cancer involves visual and palpation examination, as well as breast X-ray examination. There are imaging tests such as mammography, which is a breast examination, and ultrasound (echo) examination. If findings suggestive of cancer are found, a secondary test involves inserting a needle into the lesion to collect cells or tissue. A pathological examination will be carried out using a microscope. If necessary, a pathologist will also examine the condition and extent of the lesion. Imaging tests such as CT, MRI, abdominal ultrasound, bone scintigraphy, and PET may also be performed as needed.

[0006] Tumor markers for breast cancer detection include, for example, CEA, CA-15-3, and CA27- These blood tumor markers are known to be useful in detecting the spread of breast cancer to other organs such as the bones and liver. It has been reported that the level may increase in the case of metastasis, but it does not increase in some patients. Therefore, its usefulness is considered to be limited (Non-Patent Document 1).

[0007] Although it is still in the research stage, as shown in Patent Documents 1 to 4, it is possible to detect biological samples such as blood. The expression level of microRNA (miRNA) in the pool, or the expression level of miRNA and other proteins It has been reported that breast cancer can be detected by combining the expression level of a protein marker. do.

[0008] Specifically, Patent Document 1 describes hsa-miR-602 and hsa-miR-13 in the blood. Combining 5a-3p with known protein markers will help identify other cancers, including prostate and breast cancers. A method for detecting cancer is presented.

[0009] Patent Document 2 describes hsa-miR-23b-3p and hsa-miR-13 in blood and tissues. 5a-3p can be combined with more than five other miRNAs to detect various cancers, including breast cancer. This shows how to do this.

[0010] Patent Document 3 describes hsa-miR-92a-3p and hsa-miR-92a in blood cells. A method for detecting breast cancer using miR-2-5p, hsa-miR-92b-5p, etc. has been shown. are.

[0011] Patent document 4 describes hsa-miR-451a, hsa-miR-296-5p, A method for detecting breast cancer using hsa-miR-16-5p and other techniques has been demonstrated.

[0012] Non-patent document 3 reports that hsa-miR-760 and other miRs in the blood are significantly expressed in breast cancer patients. It has been shown to occur.

[0013] Non-patent document 4 describes the presence of hsa-miR-423-5p and hsa-miR-486- in the blood. 5p and others have been shown to decrease after breast cancer surgery.

[0014] Non-patent document 5 describes the presence of hsa-miR-4257 and hsa-miR-1915-3 in the blood. p, hsa-miR-718, etc. have been shown to be significantly expressed in breast cancer patients. do.

[0015] Non-patent document 6 reports that hsa-miR-940 and other miRs in the blood are significantly expressed in breast cancer patients. It has been shown to occur. [Prior art documents] [Patent documents]

[0016] [Patent Document 1] Special Publication No. 2012-507300 [Patent Document 2] Special Publication No. 2008-500837 [Patent Document 3] WO 10 / 123043 [Patent Document 4] US Patent Application Publication No. 2008 / 0076674 [Non-patent literature]

[0017] [Non-Patent Document 1] Edited by American Cancer Society "Breast Cancer", 2013, pp.6-9, 13, 27-28, 41-46, 52-54, 63-64, 106 [Non-patent document 2] Sobin, L. et al., “TNM Classification of Malignant Tumors 7th Edition” 2010, p. 171-181 [Non-patent document 3] Godfrey, A.C. et al., 2013, Breast Cancer Research, Vol. 15(3), p. R42 [Non-patent document 4] Cookson, VJ. et al., 2012, Cellular Oncology, Vol. 35(4), pp. 301-8 [Non-Patent Document 5] Schrauder, M.G. et al., 2012, PLoS One, Vol. 7(1), p.e29770 [Non-patent document 6] Leidner, R.S. et al., 2013, PLoS One, Vol. 8(3), p. e57841 [Non-Patent Document 7] Tamaki, K. et al., 2013, Japanese Journal of Clinical Oncology, Vol. 43(2), pp. 208-213 [Non-patent document 8] Guadagni, F. et al., 2001, Clinical Cancer Research, Vol. 7, pp. 2357-2362 Summary of the Invention [Problem to be solved by the invention]

[0018] The object of the present invention is to find a novel breast cancer tumor marker and to develop a compound capable of specifically binding to the marker. The object of the present invention is to provide a method for effectively detecting breast cancer using nucleic acids that can be used for the detection of breast cancer. As described in the , primary examination for breast cancer involves visual and palpation, as well as breast X-ray examination. There are imaging tests such as mammography, which is a type of breast cancer screening, and ultrasound. It is considered an effective breast cancer screening test for women aged 0 and over, and the American Cancer Society recommends annual screening. However, dense breasts in premenopausal women are often the cause of breast cancer. Mammography is said to have limitations in detecting breast cancer and early, minute breast cancer. (Non-Patent Document 1) In Japan, the mammography examination rate was In 2015, only 24.3% of women underwent breast cancer screening. Increasing this screening rate is essential to improve breast cancer survival rates. This is said to be a problem (Non-Patent Document 7).

[0019] Tumor markers for detecting breast cancer include the aforementioned CEA, CA-15-3, and CA27-2. However, these tumor markers are not effective in the treatment of recurrent breast cancer. It may be useful to confirm the effect, but it rarely increases in early breast cancer, so It is not considered useful for cancer screening purposes (Non-patent Document 1). Specifically, the sensitivity of CEA and CA15-3 was 6.4% and 12%, respectively, in stage 1. .2%, which is almost useless, and even in stage 4 it is only 25.0% and 62.5%, There is little significance in measuring tumor markers as a preoperative test. It can also rise for reasons other than breast cancer, making it difficult to determine whether or not breast cancer is present. Mistakenly diagnosing other cancers as breast cancer can lead to missed opportunities for appropriate treatment or to the wrong doctor. Applying this treatment would impose unnecessary financial and physical burdens on patients.

[0020] Although still in the research stage, microRNAs (miR) in biological samples such as blood There are reports on the use of the expression level of NA to distinguish breast cancer, as shown below, but none of them have been tested. It has not yet been put to practical use.

[0021] Patent document 1 describes hsa-miR-602 and hsa-miR-135a-3p in the blood. Combine with known protein markers to detect other cancers, including prostate and breast cancer However, there are methods to measure both miRNA and protein markers. This is undesirable because it increases the cost of testing and complicates the process. The method describes the detection performance, such as the specific accuracy, sensitivity, and specificity for distinguishing breast cancer. There is no industrial practicality.

[0022] Patent Document 2 describes hsa-miR-23b-3p and hsa-miR-13 in blood and tissues. 5a-3p can be combined with more than five other miRNAs to detect various cancers, including breast cancer. However, the specific accuracy, sensitivity, and specificity of detecting breast cancer have not been reported. There is no description of its functionality, and it lacks industrial practicality.

[0023] In the method described in Patent Document 3, hsa-miR-92a-3p, hsa-miR-92 A method for detecting breast cancer using miR-2-5p, hsa-miR-92b-5p, etc. is described. However, there is little information available about the specific accuracy, sensitivity, specificity, and other detection performance of breast cancer detection. Furthermore, the above miRNA markers are not available in independent samples. It has not been verified and is therefore unreliable.

[0024] Patent document 4 describes hsa-miR-451a, hsa-miR-296-5p, A method for detecting breast cancer using hsa-miR-16-5p has been shown. However, this detection method requires surgical tissue removal to obtain specimens, and this process This method places a heavy physical burden on the patient and is therefore not a desirable testing method. The law does not describe the specific accuracy, sensitivity, specificity, and other detection performance of breast cancer detection. Therefore, it has little industrial practicality.

[0025] Non-patent document 3 reports that hsa-miR-760 and other miRs in the blood are significantly expressed in breast cancer patients. However, there are still many unresolved issues regarding the detection performance, such as accuracy, sensitivity, and specificity for distinguishing breast cancer. There is no description of the specific method for detecting breast cancer, so it is difficult to put it into industrial practice. It has little utility.

[0026] Non-patent document 4 describes the presence of hsa-miR-423-5p and hsa-miR-486- in the blood. It has been shown that 5p and other factors decrease after breast cancer surgery, but the accuracy and sensitivity of detecting breast cancer are unclear. There is no description of the detection performance such as the degree of detection and specificity, and no description of the specific method for detecting breast cancer. Therefore, it is not industrially practical.

[0027] Non-patent document 5 describes the presence of hsa-miR-4257 and hsa-miR-1915-3 in the blood. p, hsa-miR-718, etc. have been shown to be significantly expressed in breast cancer patients. However, as many as 240 miRNAs are used to detect breast cancer, which increases the cost of testing and The complexity of the discrimination algorithm is a concern, making it industrially impractical.

[0028] Non-patent document 6 reports that hsa-miR-940 and other miRs in the blood are significantly expressed in breast cancer patients. However, the authors concluded that the reproducibility of this marker is poor and Furthermore, the accuracy, sensitivity, specificity, and other detection performances for breast cancer detection were investigated. There is no description of the specific method for detecting breast cancer, so it is difficult to put it into industrial practice. It has little utility.

[0029] Thus, existing tumor markers have poor performance in detecting breast cancer, and research is limited. The performance and detection methods of the stage markers have not been specifically described, so When used in this way, it can lead to unnecessary additional testing due to false positives of healthy subjects being identified as breast cancer patients, There is a possibility that treatment opportunities may be missed due to overlooking breast cancer patients. Measuring hundreds of miRNAs increases the cost of testing, so it is difficult to measure miRNAs like a health checkup. Furthermore, breast cancer screening is difficult to perform for large-scale screening. Extracting tissue is highly invasive to the patient and is therefore undesirable. It is possible to detect it from blood, and it can accurately distinguish breast cancer patients from healthy subjects. Highly accurate breast cancer markers that can distinguish between breast cancer and other cancers are needed. This dramatically reduces the risk of recurrence and also makes breast-conserving therapy possible. Therefore, there is a strong demand for a highly sensitive breast cancer marker that can detect even low-stage breast cancer. Furthermore, by providing a simpler primary breast cancer screening test, It is expected that this will lead to an increase in the rate of people seeking medical treatment. [Means for solving the problem]

[0030] As a result of intensive research to solve the above problems, the present inventors have discovered a method for extracting milk from blood that can be collected minimally invasively. We have identified multiple genes that can be used as cancer detection markers, and have isolated nucleic acids that can specifically bind to these genes. It was found that breast cancer can be significantly detected by using It was.

[0031] <Summary of the Invention> That is, the present invention has the following features. (1) Breast cancer markers: miR-4783-3p, miR-4730, and miR-1 307-3p, miR-4634, miR-663a, miR-4532, miR-77 04, miR-3178, miR-6729-5p, miR-6090, miR-473 2-5p, miR-3184-5p, miR-6727-5p, miR-6088, mi R-4674, miR-8073, miR-4787-5p, miR-1469, miR -125a-3p, miR-1233-5p, miR-885-3p, miR-6802 -5p, miR-328-5p, miR-6787-5p, miR-8069, miR- 6875-5p、miR-1246、miR-4734、miR-6757-5p、mi R-6756-5p、miR-3665、miR-6836-3p、miR-6821- 5p、miR-6805-5p、miR-4728-5p、miR-6726-5p、m iR-197-5p、miR-149-3p、miR-6850-5p、miR-447 6、miR-6858-5p、miR-564、miR-4763-3p、miR-57 5, miR-6771-5p, miR-1231, miR-1908-3p, miR-1 50-3p、miR-3937、miR-887-3p、miR-3940-5p、mi R-4741、miR-6808-5p、miR-6869-5p、miR-5090、 miR-615-5p, miR-8072, miR-128-1-5p, miR-123 8-5p、miR-365a-5p、miR-204-3p、miR-4492、miR -6785-5p、miR-6511a-5p、miR-4525、miR-1915- 5p、miR-3180、miR-6879-5p、miR-1199-5p、miR- 6746-5p、miR-711、miR-663b、miR-4707-3p、miR -6893-5p、miR-4675、miR-4638-5p、miR-4651、m iR-6087、miR-4665-5p、miR-4758-5p、miR-6887 -5p、miR-3620-5p、miR-1909-3p、miR-7641、miR -6724-5p、miR-1343-3p、miR-6780b-5p、miR-44 84、miR-4690-5p、miR-4429、miR-1227-5p、miR- 4725-3p、miR-6861-5p、miR-6812-5p、miR-3197 miR-8059, miR-3185, miR-4706, miR-4497, miR -3131、miR-6806-5p、miR-187-5p、miR-3180-3p miR-6848-5p, miR-6820-5p, miR-6800-5p, miR -6717-5p、miR-6795-5p、miR-4632-5p、miR-665 miR-6778-5p, miR-3663-3p, miR-4689, miR-21 1-3p、miR-6511b-5p、miR-4750-5p、miR-6126、m iR-614、miR-7110-5p、miR-744-5p、miR-6769a- 5p、miR-4792、miR-5787、miR-6798-5p、miR-678 1-5p、miR-4419b、miR-4446-3p、miR-4259、miR- 5572、miR-6075、miR-296-3p、miR-6891-5p、miR -4745-5p、miR-6775-5p、miR-6870-5p、miR-920 miR-4530, miR-6819-5p, miR-6825-5p, miR-78 47-3p、miR-6131、miR-4433-3p、miR-1228-5p、m iR-6743-5p、miR-1268a、miR-3917、miR-6786-5 p、miR-3154、miR-638、miR-6741-5p、miR-6889- 5p、miR-6840-3p、miR-6510-5p、miR-3188、miR- 551b-5p、miR-5001-5p、miR-1268b、miR-7107-5 p、miR-6824-5p、miR-6732-5p、miR-371a-5p、mi R-6794-5p、miR-6779-5p、miR-4271、miR-5195- 3p、miR-6762-5p、miR-939-5p、miR-1247-3p、mi R-6777-5p、miR-6722-3p、miR-3656、miR-4688、 miR-3195, miR-6766-5p, miR-4447, miR-4656, m iR-7108-5p、miR-3191-3p、miR-1273g-3p、miR- 4463, miR-2861, miR-3196, miR-6877-5p, miR-3 679-5p、miR-4442、miR-6789-5p、miR-6782-5p、 miR-486-3p、miR-6085、miR-4746-3p、miR-619- 5p、miR-937-5p、miR-6803-5p、miR-4298、miR-4 454, miR-4459, miR-7150, miR-6880-5p, miR-44 49, miR-8063, miR-4695-5p, miR-6132, miR-682 9-5p、miR-4486、miR-6805-3p、miR-6826-5p、mi R-4508、miR-1343-5p、miR-7114-5p、miR-3622a -5p、miR-6765-5p、miR-7845-5p、miR-3960、miR -6749-5p、miR-1260b、miR-6799-5p、miR-4723- 5p、miR-6784-5p、miR-5100、miR-6769b-5p、miR -1207-5p、miR-642a-3p、miR-4505、miR-4270、m iR-6721-5p、miR-7111-5p、miR-6791-5p、miR-7 109-5p、miR-4258、miR-6515-3p、miR-6851-5p、 miR-6125, miR-4749-5p, miR-4726-5p, miR-451 3, miR-6089, miR-6816-5p, miR-4466, miR-4488 At least one selected from the group consisting of miR-6752-5p and miR-4739 A kit for detecting breast cancer, comprising a nucleic acid capable of specifically binding to one polynucleotide.

[0032] (2) miR-4783-3p is hsa-miR-4783-3p and miR-47 30 is hsa-miR-4730, and miR-1307-3p is hsa-miR-1 307-3p, miR-4634 is hsa-miR-4634, and miR-6 63a is hsa-miR-663a, and miR-4532 is hsa-miR-453 2, miR-7704 is hsa-miR-7704, and miR-3178 is h sa-miR-3178 and miR-6729-5p is hsa-miR-6729- 5p, miR-6090 is hsa-miR-6090, and miR-4732- 5p is hsa-miR-4732-5p, and miR-3184-5p is hsa-mi miR-3184-5p and miR-6727-5p is hsa-miR-6727-5p , miR-6088 is hsa-miR-6088, and miR-4674 is hs a-miR-4674, miR-8073 is hsa-miR-8073, m iR-4787-5p is hsa-miR-4787-5p, and miR-1469 is h sa-miR-1469 and miR-125a-3p is hsa-miR-125a- 3p, miR-1233-5p is hsa-miR-1233-5p, and miR -885-3p is hsa-miR-885-3p, and miR-6802-5p is hs a-miR-6802-5p and miR-328-5p is hsa-miR-328- 5p, miR-6787-5p is hsa-miR-6787-5p, and miR -8069 is hsa-miR-8069, and miR-6875-5p is hsa-mi miR-6875-5p, miR-1246 is hsa-miR-1246, and mi R-4734 is hsa-miR-4734 and miR-6757-5p is hsa-m iR-6757-5p and miR-6756-5p is hsa-miR-6756-5 p, miR-3665 is hsa-miR-3665, and miR-6836-3 p is hsa-miR-6836-3p and miR-6821-5p is hsa-miR -6821-5p, and miR-6805-5p is hsa-miR-6805-5p miR-4728-5p is hsa-miR-4728-5p, and miR-67 26-5p is hsa-miR-6726-5p, and miR-197-5p is hsa- miR-197-5p and miR-149-3p are hsa-miR-149-3p. miR-6850-5p is hsa-miR-6850-5p, and miR-44 76 is hsa-miR-4476, and miR-6858-5p is hsa-miR-6 858-5p, miR-564 is hsa-miR-564, and miR-476 3-3p is hsa-miR-4763-3p, and miR-575 is hsa-miR- 575, miR-6771-5p is hsa-miR-6771-5p, and mi R-1231 is hsa-miR-1231, and miR-1908-3p is hsa-m iR-1908-3p and miR-150-3p are hsa-miR-150-3p. miR-3937 is hsa-miR-3937, and miR-887-3p is h sa-miR-887-3p and miR-3940-5p are hsa-miR-394 0-5p, miR-4741 is hsa-miR-4741, and miR-680 8-5p is hsa-miR-6808-5p, and miR-6869-5p is hsa- miR-6869-5p, miR-5090 is hsa-miR-5090, miR-615-5p is hsa-miR-615-5p and miR-8072 is hs a-miR-8072 and miR-128-1-5p are hsa-miR-128-1 -5p, miR-1238-5p is hsa-miR-1238-5p, and mi R-365a-5p is hsa-miR-365a-5p, and miR-204-3p is hsa-miR-204-3p and miR-4492 miR-6785-5p is hsa-miR-6785-5p, and miR-65 11a-5p is hsa-miR-6511a-5p, and miR-4525 is hsa- miR-4525 and miR-1915-5p are hsa-miR-1915-5p. miR-3180 is hsa-miR-3180, and miR-6879-5p is hsa-miR-6879-5p and miR-1199-5p are hsa-miR-1 199-5p, miR-6746-5p is hsa-miR-6746-5p , miR-711 is hsa-miR-711, and miR-663b is hsa-miR -663b, and miR-4707-3p is hsa-miR-4707-3p; miR-6893-5p is hsa-miR-6893-5p, and miR-4675 is hsa-miR-4675 and miR-4638-5p are hsa-miR-4638 -5p, miR-4651 is hsa-miR-4651, and miR-6087 is hsa-miR-6087, and miR-4665-5p is hsa-miR-466 5-5p, miR-4758-5p is hsa-miR-4758-5p, and m iR-6887-5p is hsa-miR-6887-5p and miR-3620-5 p is hsa-miR-3620-5p, and miR-1909-3p is hsa-miR -1909-3p, miR-7641 is hsa-miR-7641, and miR -6724-5p is hsa-miR-6724-5p, and miR-1343-3p is hsa-miR-1343-3p and miR-6780b-5p are hsa-miR- 6780b-5p, miR-4484 is hsa-miR-4484, and miR -4690-5p is hsa-miR-4690-5p, and miR-4429 is hsa -miR-4429 and miR-1227-5p is hsa-miR-1227-5p , miR-4725-3p is hsa-miR-4725-3p, and miR-6 861-5p is hsa-miR-6861-5p, and miR-6812-5p is hs a-miR-6812-5p and miR-3197 is hsa-miR-3197 miR-8059 is hsa-miR-8059, and miR-3185 is hsa- miR-3185 and miR-4706 are hsa-miR-4706 and miR -4497 is hsa-miR-4497, and miR-3131 is hsa-miR-3 131, miR-6806-5p is hsa-miR-6806-5p, and mi R-187-5p is hsa-miR-187-5p, and miR-3180-3p is h sa-miR-3180-3p and miR-6848-5p are hsa-miR-68 48-5p, and miR-6820-5p is hsa-miR-6820-5p; miR-6800-5p is hsa-miR-6800-5p, and miR-6717- 5p is hsa-miR-6717-5p and miR-6795-5p is hsa-mi miR-6795-5p and miR-4632-5p is hsa-miR-4632-5p , miR-665 is hsa-miR-665, and miR-6778-5p is h sa-miR-6778-5p and miR-3663-3p are hsa-miR-36 63-3p, miR-4689 is hsa-miR-4689, and miR-21 1-3p is hsa-miR-211-3p, and miR-6511b-5p is hsa- miR-6511b-5p and miR-4750-5p are hsa-miR-4750 -5p, miR-6126 is hsa-miR-6126, and miR-614 is hsa-miR-614 and miR-7110-5p are hsa-miR-7110- 5p, miR-744-5p is hsa-miR-744-5p, and miR-6 769a-5p is hsa-miR-6769a-5p, and miR-4792 is hsa -miR-4792, miR-5787 is hsa-miR-5787, mi R-6798-5p is hsa-miR-6798-5p, and miR-6781-5p is hsa-miR-6781-5p and miR-4419b is hsa-miR-44 19b, miR-4446-3p is hsa-miR-4446-3p, and mi R-4259 is hsa-miR-4259, and miR-5572 is hsa-miR- 5572, miR-6075 is hsa-miR-6075, and miR-296 -3p is hsa-miR-296-3p, and miR-6891-5p is hsa-mi miR-6891-5p and miR-4745-5p is hsa-miR-4745-5p , miR-6775-5p is hsa-miR-6775-5p, and miR-6 870-5p is hsa-miR-6870-5p, and miR-920 is hsa-mi miR-920, miR-4530 is hsa-miR-4530, and miR-68 19-5p is hsa-miR-6819-5p, and miR-6825-5p is hsa -miR-6825-5p and miR-7847-3p are hsa-miR-7847 -3p, miR-6131 is hsa-miR-6131, and miR-4433 -3p is hsa-miR-4433-3p, and miR-1228-5p is hsa-m iR-1228-5p and miR-6743-5p are hsa-miR-6743-5 p, miR-1268a is hsa-miR-1268a, and miR-3917 is hsa-miR-3917 and miR-6786-5p is hsa-miR-678 6-5p, miR-3154 is hsa-miR-3154, and miR-638 is hsa-miR-638, and miR-6741-5p is hsa-miR-6741 -5p, miR-6889-5p is hsa-miR-6889-5p, and mi R-6840-3p is hsa-miR-6840-3p, and miR-6510-5p is hsa-miR-6510-5p and miR-3188 is hsa-miR-318 8, miR-551b-5p is hsa-miR-551b-5p, and miR- 5001-5p is hsa-miR-5001-5p, and miR-1268b is hsa -miR-1268b and miR-7107-5p is hsa-miR-7107-5 p, miR-6824-5p is hsa-miR-6824-5p, and miR- 6732-5p is hsa-miR-6732-5p, and miR-371a-5p is h sa-miR-371a-5p and miR-6794-5p are hsa-miR-67 94-5p, and miR-6779-5p is hsa-miR-6779-5p; miR-4271 is hsa-miR-4271, and miR-5195-3p is hsa -miR-5195-3p and miR-6762-5p are hsa-miR-6762 -5p, miR-939-5p is hsa-miR-939-5p, and miR- 1247-3p is hsa-miR-1247-3p, and miR-6777-5p is h sa-miR-6777-5p and miR-6722-3p are hsa-miR-67 22-3p, miR-3656 is hsa-miR-3656, and miR-46 88 is hsa-miR-4688 and miR-3195 is hsa-miR-3195 , miR-6766-5p is hsa-miR-6766-5p, and miR-4 447 is hsa-miR-4447 and miR-4656 is hsa-miR-465 6, miR-7108-5p is hsa-miR-7108-5p, and miR- 3191-3p is hsa-miR-3191-3p, and miR-1273g-3p is hsa-miR-1273g-3p, and miR-4463 is hsa-miR-446 3, miR-2861 is hsa-miR-2861, and miR-3196 is h sa-miR-3196 and miR-6877-5p is hsa-miR-6877- 5p, miR-3679-5p is hsa-miR-3679-5p, and miR -4442 is hsa-miR-4442, and miR-6789-5p is hsa-mi miR-6789-5p and miR-6782-5p is hsa-miR-6782-5p , miR-486-3p is hsa-miR-486-3p, and miR-608 5 is hsa-miR-6085, and miR-4746-3p is hsa-miR-47 46-3p, miR-619-5p is hsa-miR-619-5p, and mi R-937-5p is hsa-miR-937-5p, and miR-6803-5p is h sa-miR-6803-5p and miR-4298 is hsa-miR-4298 miR-4454 is hsa-miR-4454 and miR-4459 is hsa -miR-4459 and miR-7150 is hsa-miR-7150, and mi R-6880-5p is hsa-miR-6880-5p, and miR-4449 is hs a-miR-4449, miR-8063 is hsa-miR-8063, m iR-4695-5p is hsa-miR-4695-5p, and miR-6132 is h sa-miR-6132 and miR-6829-5p is hsa-miR-6829- 5p, miR-4486 is hsa-miR-4486, and miR-6805- 3p is hsa-miR-6805-3p, and miR-6826-5p is hsa-mi miR-6826-5p, miR-4508 is hsa-miR-4508, and mi R-1343-5p is hsa-miR-1343-5p, and miR-7114-5p is hsa-miR-7114-5p, and miR-3622a-5p is hsa-miR -3622a-5p, and miR-6765-5p is hsa-miR-6765-5p , miR-7845-5p is hsa-miR-7845-5p, and miR-3 960 is hsa-miR-3960, and miR-6749-5p is hsa-miR- 6749-5p, miR-1260b is hsa-miR-1260b, and mi R-6799-5p is hsa-miR-6799-5p, and miR-4723-5p is hsa-miR-4723-5p, and miR-6784-5p is hsa-miR- 6784-5p, miR-5100 is hsa-miR-5100, and miR- 6769b-5p is hsa-miR-6769b-5p, and miR-1207-5p is hsa-miR-1207-5p, and miR-642a-3p is hsa-miR- 642a-3p, miR-4505 is hsa-miR-4505, and miR- 4270 is hsa-miR-4270, and miR-6721-5p is hsa-miR -6721-5p, and miR-7111-5p is hsa-miR-7111-5p. miR-6791-5p is hsa-miR-6791-5p, and miR-71 09-5p is hsa-miR-7109-5p, and miR-4258 is hsa-mi R-4258, and miR-6515-3p is hsa-miR-6515-3p , miR-6851-5p is hsa-miR-6851-5p, and miR-6125 is hsa-miR-6125 and miR-4749-5p is hsa-miR-474 9-5p, miR-4726-5p is hsa-miR-4726-5p, and m iR-4513 is hsa-miR-4513 and miR-6089 is hsa-miR -6089, and miR-6816-5p is hsa-miR-6816-5p, miR-4466 is hsa-miR-4466 and miR-4488 is hsa-mi R-4488, and miR-6752-5p is hsa-miR-6752-5p and the kit according to (1), wherein miR-4739 is hsa-miR-4739.

[0033] (3) The nucleic acid is a polynucleotide shown in (a) to (e) below: (a) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or the corresponding A polynucleotide consisting of a base sequence in which u is replaced by t, a variant thereof, or Derivatives or fragments thereof containing 15 or more consecutive bases, (b) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or the corresponding a polynucleotide comprising a base sequence in which u is t; (c) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856 or the corresponding A polynucleotide consisting of a base sequence complementary to the base sequence in which u is t in the base sequence. , a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (d) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856 or the corresponding a polynucleotide comprising a base sequence complementary to the base sequence in which u is t in the base sequence; and (e) A polynucleotide that binds to any one of the polynucleotides (a) to (d) under stringent conditions. hybridizing polynucleotides, The kit according to (1) or (2), wherein the polynucleotide is selected from the group consisting of:

[0034] (4) The kit contains another breast cancer marker, miR-760, miR-602, miR-100, miR-200, miR-300, miR-400, miR-500, miR-600, miR-760, miR-602, miR-800, miR-900, miR-1000, miR-1100, miR-1200, miR-1300, miR-1400, miR-1500, miR-1600, miR-1700, miR-1800, miR-1900, miR-2000, miR-2100, miR-2200, miR-2300, miR-2400, miR-2500, miR-2600, miR-2700, miR-2800, miR-2900 R-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a , miR-135a-3p, miR-486-5p, miR-4257, miR-92b -5p, miR-1915-3p, miR-718, miR-940, miR-296- at least one selected from the group consisting of miR-5p, miR-23b-3p, and miR-92a-3p (1) to (3) further comprising a nucleic acid capable of specifically binding to at least one polynucleotide. The kit according to any one of the above.

[0035] (5) miR-760 is hsa-miR-760 and miR-602 is hsa-mi R-602, miR-423-5p is hsa-miR-423-5p, and mi R-92a-2-5p is hsa-miR-92a-2-5p, and miR-16-5p is hsa-miR-16-5p and miR-451a is hsa-miR-451a miR-135a-3p is hsa-miR-135a-3p, and miR-48 6-5p is hsa-miR-486-5p, and miR-4257 is hsa-miR- 4257, miR-92b-5p is hsa-miR-92b-5p, and miR -1915-3p is hsa-miR-1915-3p, and miR-718 is hsa- miR-718, miR-940 is hsa-miR-940, and miR-29 6-5p is hsa-miR-296-5p, and miR-23b-3p is hsa-mi miR-23b-3p, and miR-92a-3p is hsa-miR-92a-3p The kit according to (4),

[0036] (6) The nucleic acid is a polynucleotide shown in (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (g) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 236 to 251; (h) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (j) A method for detecting a polynucleotide that is hybridized with any one of the polynucleotides (f) to (i) under stringent conditions. hybridizing polynucleotides, The kit according to (4) or (5), wherein the polynucleotide is selected from the group consisting of:

[0037] (7) The kit is for use with other breast cancer markers, such as miR-658 and miR-6842-5. p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4 534, miR-92b-3p, miR-3135b, miR-4687-3p, miR -762, miR-3619-3p, miR-4467, miR-557, miR-12 37-5p, miR-1908-5p, miR-4286, miR-6885-5p and miR-6763-5p; and The kit according to any one of (1) to (6), further comprising a nucleic acid capable of specifically binding.

[0038] (8) miR-658 is hsa-miR-658 and miR-6842-5p is hs a-miR-6842-5p and miR-6124 is hsa-miR-6124 miR-6765-3p is hsa-miR-6765-3p, and miR-710 6-5p is hsa-miR-7106-5p, and miR-4534 is hsa-miR -4534, miR-92b-3p is hsa-miR-92b-3p, and mi R-3135b is hsa-miR-3135b, and miR-4687-3p is hsa -miR-4687-3p, miR-762 is hsa-miR-762, and m iR-3619-3p is hsa-miR-3619-3p, and miR-4467 is h sa-miR-4467, miR-557 is hsa-miR-557, and mi R-1237-5p is hsa-miR-1237-5p, and miR-1908-5p is hsa-miR-1908-5p, and miR-4286 is hsa-miR-428 6, miR-6885-5p is hsa-miR-6885-5p, and m The kit according to (7), wherein iR-6763-5p is hsa-miR-6763-5p. .

[0039] (9) The nucleic acid is a polynucleotide represented by any one of (k) to (o) below: (k) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (l) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 252 to 269; (m) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (n) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (o) a polynucleotide that binds to any one of the polynucleotides (k) to (n) under stringent conditions; hybridizing polynucleotides, The kit according to (7) or (8), wherein the polynucleotide is selected from the group consisting of:

[0040] (10) The kit comprises a group consisting of all breast cancer markers described in (1) or (2). At least one polynucleotide capable of specifically binding to each of at least two polynucleotides selected from The kit according to any one of (1) to (9), each of which contains two nucleic acids.

[0041] (11) miR-4783-3p, miR-4730, miR- 1307-3p, miR-4634, miR-663a, miR-4532, miR-7 704, miR-3178, miR-6729-5p, miR-6090, miR-47 32-5p, miR-3184-5p, miR-6727-5p, miR-6088, m iR-4674, miR-8073, miR-4787-5p, miR-1469, mi R-125a-3p, miR-1233-5p, miR-885-3p, miR-680 2-5p, miR-328-5p, miR-6787-5p, miR-8069, miR -6875-5p, miR-1246, miR-4734, miR-6757-5p, m iR-6756-5p, miR-3665, miR-6836-3p, miR-6821 -5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-44 76, miR-6858-5p, miR-564, miR-4763-3p, miR-5 75, miR-6771-5p, miR-1231, miR-1908-3p, miR- 150-3p, miR-3937, miR-887-3p, miR-3940-5p, m iR-4741, miR-6808-5p, miR-6869-5p, miR-5090 , miR-615-5p, miR-8072, miR-128-1-5p, miR-12 38-5p, miR-365a-5p, miR-204-3p, miR-4492, mi R-6785-5p, miR-6511a-5p, miR-4525, miR-1915 -5p, miR-3180, miR-6879-5p, miR-1199-5p, miR -6746-5p、miR-711、miR-663b、miR-4707-3p、mi R-6893-5p、miR-4675、miR-4638-5p、miR-4651、 miR-6087, miR-4665-5p, miR-4758-5p, miR-688 7-5p、miR-3620-5p、miR-1909-3p、miR-7641、mi R-6724-5p、miR-1343-3p、miR-6780b-5p、miR-4 484、miR-4690-5p、miR-4429、miR-1227-5p、miR -4725-3p、miR-6861-5p、miR-6812-5p、miR-319 7、miR-8059、miR-3185、miR-4706、miR-4497、mi R-3131、miR-6806-5p、miR-187-5p、miR-3180-3 p、miR-6848-5p、miR-6820-5p、miR-6800-5p、mi R-6717-5p、miR-6795-5p、miR-4632-5p、miR-66 5, miR-6778-5p, miR-3663-3p, miR-4689, miR-2 11-3p、miR-6511b-5p、miR-4750-5p、miR-6126、 miR-614, miR-7110-5p, miR-744-5p, miR-6769a -5p、miR-4792、miR-5787、miR-6798-5p、miR-67 81-5p、miR-4419b、miR-4446-3p、miR-4259、miR -5572、miR-6075、miR-296-3p、miR-6891-5p、mi R-4745-5p、miR-6775-5p、miR-6870-5p、miR-92 0, miR-4530, miR-6819-5p, miR-6825-5p, miR-7 847-3p、miR-6131、miR-4433-3p、miR-1228-5p、 miR-6743-5p、miR-1268a、miR-3917、miR-6786- 5p、miR-3154、miR-638、miR-6741-5p、miR-6889 -5p、miR-6840-3p、miR-6510-5p、miR-3188、miR -551b-5p、miR-5001-5p、miR-1268b、miR-7107- 5p、miR-6824-5p、miR-6732-5p、miR-371a-5p、m iR-6794-5p、miR-6779-5p、miR-4271、miR-5195 -3p、miR-6762-5p、miR-939-5p、miR-1247-3p、m iR-6777-5p、miR-6722-3p、miR-3656、miR-4688 miR-3195, miR-6766-5p, miR-4447, miR-4656 miR-7108-5p、miR-3191-3p、miR-1273g-3p、miR -4463、miR-2861、miR-3196、miR-6877-5p、miR- 3679-5p、miR-4442、miR-6789-5p、miR-6782-5p miR-486-3p, miR-6085, miR-4746-3p, miR-619 -5p、miR-937-5p、miR-6803-5p、miR-4298、miR- 4454、miR-4459、miR-7150、miR-6880-5p、miR-4 449, miR-8063, miR-4695-5p, miR-6132, miR-68 29-5p、miR-4486、miR-6805-3p、miR-6826-5p、m iR-4508, miR-1343-5p, miR-7114-5p, miR-3622 a-5p, miR-6765-5p, miR-7845-5p, miR-3960, mi R-6749-5p, miR-1260b, miR-6799-5p, miR-4723 -5p, miR-6784-5p, miR-5100, miR-6769b-5p, mi R-1207-5p, miR-642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR- 7109-5p, miR-4258, miR-6515-3p, miR-6851-5p , miR-6125, miR-4749-5p, miR-4726-5p, miR-45 13, miR-6089, miR-6816-5p, miR-4466, miR-448 8, at least one selected from the group consisting of miR-6752-5p and miR-4739 A device for detecting breast cancer, comprising a nucleic acid capable of specifically binding to one polynucleotide.

[0042] (12) miR-4783-3p is hsa-miR-4783-3p, and miR-4 730 is hsa-miR-4730, and miR-1307-3p is hsa-miR- 1307-3p, miR-4634 is hsa-miR-4634, and miR- 663a is hsa-miR-663a, and miR-4532 is hsa-miR-45 32, miR-7704 is hsa-miR-7704, and miR-3178 is hsa-miR-3178 and miR-6729-5p are hsa-miR-6729 -5p, miR-6090 is hsa-miR-6090, and miR-4732 -5p is hsa-miR-4732-5p, and miR-3184-5p is hsa-m iR-3184-5p and miR-6727-5p are hsa-miR-6727-5 p, miR-6088 is hsa-miR-6088, and miR-4674 is h sa-miR-4674 and miR-8073 is hsa-miR-8073; miR-4787-5p is hsa-miR-4787-5p, and miR-1469 is hsa-miR-1469 and miR-125a-3p are hsa-miR-125a -3p, miR-1233-5p is hsa-miR-1233-5p, and mi R-885-3p is hsa-miR-885-3p, and miR-6802-5p is h sa-miR-6802-5p and miR-328-5p is hsa-miR-328 -5p, miR-6787-5p is hsa-miR-6787-5p, and mi R-8069 is hsa-miR-8069, and miR-6875-5p is hsa-m iR-6875-5p, miR-1246 is hsa-miR-1246, and m iR-4734 is hsa-miR-4734, and miR-6757-5p is hsa- miR-6757-5p and miR-6756-5p are hsa-miR-6756- 5p, miR-3665 is hsa-miR-3665, and miR-6836- 3p is hsa-miR-6836-3p, and miR-6821-5p is hsa-mi miR-6821-5p and miR-6805-5p is hsa-miR-6805-5p , miR-4728-5p is hsa-miR-4728-5p, and miR-6 726-5p is hsa-miR-6726-5p, and miR-197-5p is hsa -miR-197-5p and miR-149-3p is hsa-miR-149-3p , miR-6850-5p is hsa-miR-6850-5p, and miR-4 476 is hsa-miR-4476, and miR-6858-5p is hsa-miR- 6858-5p, miR-564 is hsa-miR-564, and miR-47 63-3p is hsa-miR-4763-3p, and miR-575 is hsa-miR -575, miR-6771-5p is hsa-miR-6771-5p, and m iR-1231 is hsa-miR-1231, and miR-1908-3p is hsa- miR-1908-3p and miR-150-3p are hsa-miR-150-3p , miR-3937 is hsa-miR-3937, and miR-887-3p is hsa-miR-887-3p and miR-3940-5p are hsa-miR-39 40-5p, miR-4741 is hsa-miR-4741, and miR-68 08-5p is hsa-miR-6808-5p, and miR-6869-5p is hsa -miR-6869-5p, and miR-5090 is hsa-miR-5090 , miR-615-5p is hsa-miR-615-5p, and miR-8072 is h sa-miR-8072 and miR-128-1-5p is hsa-miR-128- 1-5p, miR-1238-5p is hsa-miR-1238-5p, and m iR-365a-5p is hsa-miR-365a-5p, and miR-204-3p is hsa-miR-204-3p and miR-4492 is hsa-miR-4492 , miR-6785-5p is hsa-miR-6785-5p, and miR-6 511a-5p is hsa-miR-6511a-5p, and miR-4525 is hsa -miR-4525 and miR-1915-5p is hsa-miR-1915-5p , miR-3180 is hsa-miR-3180, and miR-6879-5p is hsa-miR-6879-5p, and miR-1199-5p is hsa-miR- 1199-5p, and miR-6746-5p is hsa-miR-6746-5p. miR-711 is hsa-miR-711, and miR-663b is hsa-mi R-663b, miR-4707-3p is hsa-miR-4707-3p , miR-6893-5p is hsa-miR-6893-5p, and miR-4675 is hsa-miR-4675, and miR-4638-5p is hsa-miR-463 8-5p, miR-4651 is hsa-miR-4651, and miR-608 7 is hsa-miR-6087, and miR-4665-5p is hsa-miR-46 65-5p, and miR-4758-5p is hsa-miR-4758-5p; miR-6887-5p is hsa-miR-6887-5p, and miR-3620- 5p is hsa-miR-3620-5p and miR-1909-3p is hsa-mi miR-1909-3p, miR-7641 is hsa-miR-7641, and mi R-6724-5p is hsa-miR-6724-5p, and miR-1343-3p is hsa-miR-1343-3p, and miR-6780b-5p is hsa-miR -6780b-5p, miR-4484 is hsa-miR-4484, and mi R-4690-5p is hsa-miR-4690-5p, and miR-4429 is hs a-miR-4429 and miR-1227-5p is hsa-miR-1227-5 p, miR-4725-3p is hsa-miR-4725-3p, and miR- 6861-5p is hsa-miR-6861-5p and miR-6812-5p is h sa-miR-6812-5p and miR-3197 is hsa-miR-3197 miR-8059 is hsa-miR-8059, and miR-3185 is hsa -miR-3185 and miR-4706 is hsa-miR-4706, and mi R-4497 is hsa-miR-4497, and miR-3131 is hsa-miR- 3131, miR-6806-5p is hsa-miR-6806-5p, and m iR-187-5p is hsa-miR-187-5p, and miR-3180-3p is hsa-miR-3180-3p and miR-6848-5p are hsa-miR-6 848-5p, miR-6820-5p is hsa-miR-6820-5p , miR-6800-5p is hsa-miR-6800-5p, and miR-6717 -5p is hsa-miR-6717-5p, and miR-6795-5p is hsa-m iR-6795-5p and miR-4632-5p are hsa-miR-4632-5 p, miR-665 is hsa-miR-665, and miR-6778-5p is hsa-miR-6778-5p and miR-3663-3p are hsa-miR-3 663-3p, miR-4689 is hsa-miR-4689, and miR-2 11-3p is hsa-miR-211-3p, and miR-6511b-5p is hsa -miR-6511b-5p and miR-4750-5p is hsa-miR-475 0-5p, miR-6126 is hsa-miR-6126, and miR-614 is hsa-miR-614 and miR-7110-5p is hsa-miR-7110 -5p, miR-744-5p is hsa-miR-744-5p, and miR- 6769a-5p is hsa-miR-6769a-5p, and miR-4792 is hs a-miR-4792, miR-5787 is hsa-miR-5787, m iR-6798-5p is hsa-miR-6798-5p and miR-6781-5 p is hsa-miR-6781-5p, and miR-4419b is hsa-miR-4 419b, miR-4446-3p is hsa-miR-4446-3p, and m iR-4259 is hsa-miR-4259 and miR-5572 is hsa-miR -5572, miR-6075 is hsa-miR-6075, and miR-29 6-3p is hsa-miR-296-3p, and miR-6891-5p is hsa-m iR-6891-5p and miR-4745-5p are hsa-miR-4745-5 p, miR-6775-5p is hsa-miR-6775-5p, and miR- 6870-5p is hsa-miR-6870-5p, and miR-920 is hsa-m iR-920, miR-4530 is hsa-miR-4530, and miR-6 819-5p is hsa-miR-6819-5p and miR-6825-5p is hs a-miR-6825-5p and miR-7847-3p are hsa-miR-784 7-3p, miR-6131 is hsa-miR-6131, and miR-443 3-3p is hsa-miR-4433-3p, and miR-1228-5p is hsa- miR-1228-5p and miR-6743-5p are hsa-miR-6743- 5p, miR-1268a is hsa-miR-1268a, and miR-391 7 is hsa-miR-3917, and miR-6786-5p is hsa-miR-67 86-5p, miR-3154 is hsa-miR-3154, and miR-63 8 is hsa-miR-638, and miR-6741-5p is hsa-miR-674 1-5p, miR-6889-5p is hsa-miR-6889-5p, and m iR-6840-3p is hsa-miR-6840-3p, and miR-6510-5 p is hsa-miR-6510-5p, and miR-3188 is hsa-miR-31 88, miR-551b-5p is hsa-miR-551b-5p, and miR -5001-5p is hsa-miR-5001-5p, and miR-1268b is hs a-miR-1268b and miR-7107-5p is hsa-miR-7107- 5p, miR-6824-5p is hsa-miR-6824-5p, and miR -6732-5p is hsa-miR-6732-5p, and miR-371a-5p is hsa-miR-371a-5p and miR-6794-5p are hsa-miR-6 794-5p, miR-6779-5p is hsa-miR-6779-5p , miR-4271 is hsa-miR-4271, and miR-5195-3p is hs a-miR-5195-3p and miR-6762-5p are hsa-miR-676 2-5p, miR-939-5p is hsa-miR-939-5p, and miR -1247-3p is hsa-miR-1247-3p, and miR-6777-5p is hsa-miR-6777-5p and miR-6722-3p are hsa-miR-6 722-3p, miR-3656 is hsa-miR-3656, and miR-4 688 is hsa-miR-4688, and miR-3195 is hsa-miR-319 5, miR-6766-5p is hsa-miR-6766-5p, and miR- 4447 is hsa-miR-4447 and miR-4656 is hsa-miR-46 56, miR-7108-5p is hsa-miR-7108-5p, and miR -3191-3p is hsa-miR-3191-3p, and miR-1273g-3p is hsa-miR-1273g-3p, and miR-4463 is hsa-miR-44 63, miR-2861 is hsa-miR-2861, and miR-3196 is hsa-miR-3196 and miR-6877-5p are hsa-miR-6877 -5p, miR-3679-5p is hsa-miR-3679-5p, and mi R-4442 is hsa-miR-4442 and miR-6789-5p is hsa-m iR-6789-5p and miR-6782-5p are hsa-miR-6782-5 p, miR-486-3p is hsa-miR-486-3p, and miR-60 85 is hsa-miR-6085 and miR-4746-3p is hsa-miR-4 746-3p, miR-619-5p is hsa-miR-619-5p, and m iR-937-5p is hsa-miR-937-5p, and miR-6803-5p is hsa-miR-6803-5p and miR-4298 , miR-4454 is hsa-miR-4454, and miR-4459 is hs a-miR-4459, miR-7150 is hsa-miR-7150, m iR-6880-5p is hsa-miR-6880-5p, and miR-4449 is h sa-miR-4449, and miR-8063 is hsa-miR-8063; miR-4695-5p is hsa-miR-4695-5p, and miR-6132 is hsa-miR-6132 and miR-6829-5p are hsa-miR-6829 -5p, miR-4486 is hsa-miR-4486, and miR-6805 -3p is hsa-miR-6805-3p, and miR-6826-5p is hsa-m iR-6826-5p, miR-4508 is hsa-miR-4508, and m iR-1343-5p is hsa-miR-1343-5p, and miR-7114-5 p is hsa-miR-7114-5p, and miR-3622a-5p is hsa-mi miR-3622a-5p and miR-6765-5p are hsa-miR-6765-5 p, miR-7845-5p is hsa-miR-7845-5p, and miR- 3960 is hsa-miR-3960 and miR-6749-5p is hsa-miR -6749-5p, miR-1260b is hsa-miR-1260b, and m iR-6799-5p is hsa-miR-6799-5p and miR-4723-5 p is hsa-miR-4723-5p and miR-6784-5p is hsa-miR -6784-5p, miR-5100 is hsa-miR-5100, and miR -6769b-5p is hsa-miR-6769b-5p, and miR-1207-5 p is hsa-miR-1207-5p, and miR-642a-3p is hsa-miR -642a-3p, miR-4505 is hsa-miR-4505, and miR -4270 is hsa-miR-4270, and miR-6721-5p is hsa-mi miR-6721-5p and miR-7111-5p is hsa-miR-7111-5p , miR-6791-5p is hsa-miR-6791-5p, and miR-7 109-5p is hsa-miR-7109-5p, and miR-4258 is hsa-m iR-4258 and miR-6515-3p is hsa-miR-6515-3p miR-6851-5p is hsa-miR-6851-5p, and miR-612 5 is hsa-miR-6125, and miR-4749-5p is hsa-miR-47 49-5p, and miR-4726-5p is hsa-miR-4726-5p; miR-4513 is hsa-miR-4513 and miR-6089 is hsa-mi R-6089, and miR-6816-5p is hsa-miR-6816-5p , miR-4466 is hsa-miR-4466, and miR-4488 is hsa-m iR-4488 and miR-6752-5p is hsa-miR-6752-5p and miR-4739 is hsa-miR-4739. Chair.

[0043] (13) The nucleic acid is a polynucleotide shown in any one of (a) to (e) below: (a) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or the corresponding A polynucleotide consisting of a base sequence in which u is replaced by t, a variant thereof, or Derivatives or fragments thereof containing 15 or more consecutive bases, (b) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856, or the corresponding a polynucleotide comprising a base sequence complementary to the base sequence in which u is t in the base sequence; (c) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856 or the corresponding A polynucleotide consisting of a base sequence complementary to the base sequence in which u is t in the base sequence. , a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (d) a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 235 and 851 to 856 or the corresponding a polynucleotide comprising a base sequence complementary to the base sequence in which u is t in the base sequence; and (e) A polynucleotide that binds to any one of the polynucleotides (a) to (d) under stringent conditions. hybridizing polynucleotides, The device according to (11) or (12), which is a polynucleotide selected from the group consisting of Chair.

[0044] (14) The device is capable of detecting other breast cancer markers, such as miR-760 and miR-602. , miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-4 51a, miR-135a-3p, miR-486-5p, miR-4257, miR- 92b-5p, miR-1915-3p, miR-718, miR-940, miR-2 96-5p, miR-23b-3p, and miR-92a-3p (11) to (12), further comprising a nucleic acid capable of specifically binding to at least one polynucleotide. (13) A device according to any one of (13).

[0045] (15) miR-760 is hsa-miR-760 and miR-602 is hsa-m iR-602, miR-423-5p is hsa-miR-423-5p, and m iR-92a-2-5p is hsa-miR-92a-2-5p, and miR-16-5 p is hsa-miR-16-5p and miR-451a is hsa-miR-451a , miR-135a-3p is hsa-miR-135a-3p, and miR-4 86-5p is hsa-miR-486-5p, and miR-4257 is hsa-miR -4257, miR-92b-5p is hsa-miR-92b-5p, and mi R-1915-3p is hsa-miR-1915-3p, and miR-718 is hsa -miR-718, miR-940 is hsa-miR-940, and miR-2 96-5p is hsa-miR-296-5p, and miR-23b-3p is hsa-m iR-23b-3p and miR-92a-3p are hsa-miR-92a-3 The device according to (14), wherein p.

[0046] (16) The nucleic acid is a polynucleotide shown in (f) to (j) below: (f) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (g) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 236 to 251; (h) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (i) a base sequence represented by any one of SEQ ID NOs: 236 to 251 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (j) A method for detecting a polynucleotide that is hybridized with any one of the polynucleotides (f) to (i) under stringent conditions. hybridizing polynucleotides, The device according to (14) or (15), which is a polynucleotide selected from the group consisting of Chair.

[0047] (17) The device is capable of detecting other breast cancer markers, such as miR-658 and miR-684. 2-5p, miR-6124, miR-6765-3p, miR-7106-5p, mi R-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR -1237-5p, miR-1908-5p, miR-4286, miR-6885-5 at least one polynucleotide selected from the group consisting of miR-6763-5p and miR-6763-5p The device according to any one of (11) to (16), further comprising a nucleic acid capable of specifically binding to the peptide. Vice.

[0048] (18) miR-658 is hsa-miR-658, and miR-6842-5p is h sa-miR-6842-5p and miR-6124 is hsa-miR-6124 miR-6765-3p is hsa-miR-6765-3p, and miR-71 06-5p is hsa-miR-7106-5p, and miR-4534 is hsa-mi R-4534, miR-92b-3p is hsa-miR-92b-3p, and m iR-3135b is hsa-miR-3135b, and miR-4687-3p is hs a-miR-4687-3p, miR-762 is hsa-miR-762, miR-3619-3p is hsa-miR-3619-3p, and miR-4467 is hsa-miR-4467, miR-557 is hsa-miR-557, m iR-1237-5p is hsa-miR-1237-5p and miR-1908-5 p is hsa-miR-1908-5p and miR-4286 is hsa-miR-42 86, miR-6885-5p is hsa-miR-6885-5p, and The method according to (17), wherein miR-6763-5p is hsa-miR-6763-5p. Vice.

[0049] (19) The nucleic acid is a polynucleotide shown in (k) to (o) below: (k) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (l) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 252 to 269; (m) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (n) a base sequence represented by any one of SEQ ID NOs: 252 to 269 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (o) a polynucleotide that binds to any one of the polynucleotides (k) to (n) under stringent conditions; hybridizing polynucleotides, The device according to (17) or (18), which is a polynucleotide selected from the group consisting of Chair.

[0050] (20) The device is a device for measurement by hybridization technology. The device according to any one of (11) to (19).

[0051] (21) The method according to (20), wherein the hybridization technique is a nucleic acid array technique. device.

[0052] (22) The device is a marker selected from all of the breast cancer markers described in (11) or (12). At least one polynucleotide capable of specifically binding to each of the at least two polynucleotides selected The device according to any one of (11) to (21), comprising two nucleic acids.

[0053] (23) The kit according to any one of (1) to (10) or (11) to (22). The expression level of a target nucleic acid in a specimen of a subject is measured using the device described in The expression levels measured and the control expression levels of healthy individuals measured in the same manner were used to determine whether the subject had breast cancer. This includes in vitro assessment of breast cancer status or the absence of breast cancer. , breast cancer detection methods.

[0054] (24) The method according to (23), wherein the subject is a human.

[0055] (25) The method according to (23) or (24), wherein the sample is blood, serum, or plasma.

[0056] <Terminology> Terms used herein have the following definitions. Nucleotide, polynucleotide, DNA, RNA, etc. are abbreviated as "base sequence" Guidelines for the Preparation of Specifications Including Sequences or Amino Acid Sequences" (edited by the Japan Patent Office) and and conventions in the art shall be followed.

[0057] As used herein, the term "polynucleotide" refers to RNA, DNA, and RNA / DNA ( The term "DNA" refers to nucleic acids that include both cDNA and chimeric DNA. The above-mentioned RNA includes total DNA, genomic DNA, and synthetic DNA. l RNA, mRNA, rRNA, miRNA, siRNA, snoRNA, snRNA , including both non-coding RNA and synthetic RNA. As used herein, "synthetic DNA" and "synthetic RNA" refer to a DNA having a predetermined base sequence (natural sequence). or a non-natural sequence), using an automated nucleic acid synthesizer, for example. As used herein, the term "non-natural sequence" refers to DNA and RNA that have been artificially produced. and is intended to mean a sequence that differs from the native sequence, e.g., by one or more nucleotides. sequences containing substitutions, deletions, insertions and / or additions of one or more modified sequences (i.e., mutant sequences); The term "sequence" as used herein also encompasses sequences containing nucleotides (i.e., modified sequences), etc. Polynucleotide is used interchangeably with nucleic acid.

[0058] As used herein, the term "fragment" refers to a fragment having a continuous partial base sequence of a polynucleotide. It is a polynucleotide (including oligonucleotides) consisting of 15 or more bases, preferably 1 It is desirable that the length is 7 bases or more, more preferably 19 bases or more.

[0059] As used herein, the term "gene" refers not only to RNA and double-stranded DNA, but also to any of the components thereof. Each strand contains a single strand of DNA, such as the positive strand (or sense strand) or the complementary strand (or antisense strand). The term "subject matter" is intended to encompass all subjects, and is not particularly limited by its length. Therefore, in this specification, unless otherwise specified, the term "gene" refers to human genomic DNA. double-stranded DNA containing cDNA, single-stranded DNA (positive strand) containing cDNA, and a sequence complementary to the positive strand. single-stranded DNA (complementary strand), microRNA (miRNA), and fragments thereof, The term "gene" refers to a specific base sequence (or sequence number). Not only are the genes expressed, but the RNA encoded by those genes also has biological functions. RNAs that are homologs (i.e., homologs or orthologs), genetic polymorphisms, etc. Such homologs, variants or derivatives are also encompassed by "nucleic acids" that encode such homologs, variants or derivatives. Specifically, the "nucleic acid" encoding the derivative can be generated under the stringent conditions described below. Under the conditions, a base sequence represented by any one of SEQ ID NOs: 1 to 871, or "Nucleic acid" having a base sequence that hybridizes with the complementary sequence of the base sequence in which u is t The term "gene" does not refer to a specific functional region, and examples include: It can include expression control regions, coding regions, exons, or introns. The molecule may be contained within the cell, or may be released outside the cell and exist independently. It may be contained within small vesicles called exosomes.

[0060] As used herein, "exosomes" (also known as "exosomes") are molecules secreted from cells. Exosomes are small vesicles enclosed in a lipid bilayer membrane. They originate from multivesicular endosomes and are extracellular. When released into the environment, they lose internal biological substances such as genes (e.g., RNA and DNA) and proteins. Exosomes are contained in bodily fluids such as blood, serum, plasma, serum, and lymph. It is known that

[0061] As used herein, the term "transcription product" refers to a RNA synthesized using the DNA sequence of a gene as a template. A refers to the region called the promoter upstream of the gene where RNA polymerase is located. and binds to the 3' end of the DNA, and binds a ribonucleotide to the 3' end so that it is complementary to the base sequence of the DNA. This RNA contains not only the gene itself but also the the region from the transcription start site to the poly(A) sequence, including the coding region, exon or intron The entire sequence is included, all the way to the termini.

[0062] In addition, in this specification, unless otherwise specified, "microRNA (miRNA)" means It is transcribed as a hairpin-like RNA precursor and has RNase III cleavage activity. It is cleaved by sRNA cleavage enzymes and incorporated into a protein complex called RISC, Non-coding RNAs of 15 to 25 bases involved in RNA translational repression are used intentionally. Furthermore, as used herein, "miRNA" is represented by a specific base sequence (or SEQ ID NO:). In addition to the miRNAs themselves, we also study the precursors of these miRNAs (pre-miRNAs, p ri-miRNAs), and miRNAs with equivalent biological functions, e.g., homologs ( It also includes variants such as homologs or orthologs, genetic polymorphisms, and derivatives. Such precursors, homologues, variants or derivatives include, in particular, those listed in the miRBase Identified by release 20 (http: / / www.mirbase.org / ) Any of SEQ ID NOs: 1 to 871 can be isolated under the stringent conditions described below. A nucleic acid sequence that hybridizes with the complementary sequence of any of the specific nucleic acid sequences represented by Furthermore, the term "miRNA" as used herein can be used to refer to a specific miRNA. " may be a gene product of a miR gene, and such a gene product is a mature miR NA (for example, 15 to 25 bases involved in the translational repression of mRNA as described above, or 19 to 25 bases, non-coding RNA) or miRNA precursor (e.g., pr miRNAs (e-miRNA or pri-miRNA).

[0063] As used herein, the term "probe" refers to RNA generated by gene expression or a probe derived therefrom. Polynucleotides and / or includes polynucleotides complementary thereto.

[0064] As used herein, the term "primer" refers to an RNA generated by gene expression or a primer therefor. A polynucleotide that specifically recognizes and amplifies the polynucleotide from which it is derived and / or Here, the term "complementary polynucleotide (complementary strand, "(reverse strand)" refers to a base sequence defined by any one of SEQ ID NOs: 1 to 871, or the corresponding a full-length polynucleotide sequence consisting of the base sequence in which u is t, or The partial sequence (for convenience, this will be called the positive strand) is A:T(U), G:C, It means a polynucleotide that is in a base-complementary relationship based on base pairing. However, such a complementary strand may form a completely complementary sequence with the base sequence of the target positive strand. Not limited to, but complementary enough to hybridize with the target positive strand under stringent conditions. It may be related to one another.

[0065] As used herein, "stringent conditions" refers to conditions under which a nucleic acid probe is highly sensitive to other sequences. to a greater extent than (e.g., the average of background measurements + the standard of background measurements) The conditions are those under which the hybridization occurs with respect to the target sequence with a standard error of at least 2 times the measured value. Stringent conditions are sequence-dependent and depend on the environment in which the hybridization occurs. The stringency of hybridization and / or washing conditions can be controlled. By doing so, target sequences that are 100% complementary to the nucleic acid probe can be identified. Specific examples of "stringent conditions" will be described later.

[0066] As used herein, the term "Tm value" refers to the time at which the double-stranded portion of a polynucleotide is denatured into a single strand. means the temperature at which double-stranded and single-stranded molecules exist in a 1:1 ratio.

[0067] As used herein, the term "variant" refers to a naturally occurring variant of a nucleic acid resulting from polymorphism, mutation, etc. or a variant thereof, or any of the base sequences of SEQ ID NOs: 1 to 871, or In the base sequence where u is t, or a partial sequence thereof, one or more bases are deleted or substituted. , a variant containing an addition or insertion, or each of the base sequences or a partial sequence thereof and about 90% Mutations showing % identity of 95% or more, 97% or more, 98% or more, or 99% or more or a polynucleotide or oligonucleotide containing said base sequence or a partial sequence thereof The term "nucleotide sequence" refers to a nucleic acid that hybridizes to the nucleic acid under stringent conditions as defined above.

[0068] As used herein, "plurality" refers to an integer of about 10, 9, 8, 7, 6, 5, 4, 3, or 2. It means a number.

[0069] In this specification, "mutants" refer to mutations that have been produced by site-directed mutagenesis, PCR, or other methods. They can be produced using well-known techniques such as natural mutagenesis.

[0070] As used herein, "% identity" refers to the percentage of identity between proteins or sequences as determined by BLAST or FASTA as described above. using a gene search system, with or without introducing gaps, can be determined (Zheng Zhang et al., 2000, J. Comput. B iol., Vol. 7, p. 203-214; Altschul, SF et al., 1990, Jo Journal of Molecular Biology, Vol. 215, p. 403-41 0; Pearson, WR et al., 1988, Proc. Natl. Acad. Sci .USA, Vol. 85, p2444-2448).

[0071] As used herein, the term "derivative" refers to a modified nucleic acid, including, but not limited to, a modified nucleic acid, such as a nucleic acid with a fluorophore. Labeled derivatives, modified nucleotides (e.g., halogen, alkyl such as methyl, methoxy) Reconstruction of nucleotides and bases containing groups such as alkoxy, thio, and carboxymethyl Nucleotides that have undergone synthesis, double bond saturation, deamination, and substitution of oxygen molecules with sulfur molecules. derivatives containing PNA (peptide nucleic acid; Niel Sen, PE et al., 1991, Science, Vol. 254, pp. 1497-500) LNA (locked nucleic acid; Obika, S. et al., 1998, Tetrahedron Lett., Vol. 39, p. 5401-5404) means.

[0072] As used herein, a polynucleotide selected from the miRNAs that are breast cancer markers is The "nucleic acid" capable of specifically binding to a peptide is a synthesized or prepared nucleic acid, specifically a "nucleic acid" and a "primer" or "acid probe" for detecting the presence or absence of breast cancer in a subject. or whether or not you have breast cancer, the extent of your cancer, whether or not your breast cancer has improved, and the extent of your improvement, Potential candidates useful for diagnosing sensitivity to treatment or for preventing, ameliorating, or treating breast cancer These include breast cancer screening, ... In relation to disease, in vivo, particularly in samples of body fluids such as blood and urine, any of SEQ ID NOs: 1 to 871 It specifically recognizes and binds to the transcription product or its cDNA synthetic nucleic acid represented by either These nucleotides include nucleotides, oligonucleotides and polynucleotides. Based on the above properties, the nucleotides, oligonucleotides and polynucleotides can be used in vivo and in tissues. They can be used as probes to detect the above genes expressed in tissues and cells, and also as probes for detecting genes expressed in vivo. The resulting primers can be effectively used as primers for amplifying the expressed genes.

[0073] The term "detection" as used herein means inspection, measurement, detection, or decision support. In addition, the term "evaluation" as used herein refers to test results or measurement results. It is used to include assisting in diagnosis or evaluation based on the above.

[0074] As used herein, a "subject" refers to a human, a primate, including a chimpanzee, a dog, a cat, or the like. Any pet animals, livestock animals such as cows, horses, sheep, goats, rodents such as mice and rats A "healthy individual" also refers to such a mammal, It means an animal that is not affected by the cancer to be detected.

[0075] As used herein, "P" or "P value" refers to the probability that a statistical test will yield a positive result under the null hypothesis. indicates the probability that a statistic more extreme than the statistic calculated from the actual data will be observed. Therefore, the smaller the "P" or "P value," the more significant the difference between the compared subjects.

[0076] As used herein, "sensitivity" refers to the value of (the number of true positives) / (the number of true positives + the number of false negatives). High sensitivity means that breast cancer can be detected early and the cancer can be completely excised. This leads to removal and reduced recurrence rates.

[0077] As used herein, "specificity" means (number of true negatives) / (number of true negatives + number of false positives). High specificity can prevent unnecessary additional testing due to misclassification of healthy subjects as breast cancer patients. This will prevent the practice from being carried out, reducing the burden on patients and cutting medical costs.

[0078] In this specification, "accuracy" means the value of (number of true positives + number of true negatives) / (total number of cases). Accuracy indicates the percentage of all samples for which the discrimination results were correct, and is used to evaluate detection performance. This will be the first indicator.

[0079] In this specification, the term "specimen" to be determined, detected or diagnosed refers to a specimen that is used to determine whether or not breast cancer has occurred, whether breast The expression of the gene of the present invention changes with the progression of cancer and the effect of treatment on breast cancer. This refers to tissues and biological materials, specifically breast tissue and its surrounding blood vessels, lymph nodes, and organs. Organs suspected of metastasis, skin, and body fluids such as blood, urine, saliva, sweat, and tissue exudates, This refers to serum, plasma, and other substances prepared from feces, hair, etc. This refers to body samples, specifically genes such as RNA and miRNA.

[0080] As used herein, "hsa-miR-4783-3p gene" or "hsa-mi The term "miR-4783-3p" refers to hsa-miR-4783-3p as set forth in SEQ ID NO: 1. p gene (miRBase Accession No. MIMAT0019947) It also includes homologs or orthologs from other species. The 3p genes are described in Persson H et al., 2011, Cancer Res, vol. 71, p. 78-86. "83-3p" has a hairpin-like structure as its precursor "hsa-mir-4783" (miRBase Accession No. MI0017428, SEQ ID NO: 270) is known.

[0081] As used herein, "hsa-miR-4730 gene" or "hsa-miR-4 The term "miR-4730" refers to the hsa-miR-4730 gene (miRB) set forth in SEQ ID NO: 2. ase Accession No. MIMAT0019852) and other species homologues The hsa-miR-4730 gene is a member of the Perss On H et al., 2011, Cancer Res, Vol. 71, p. 78-86 hsa-miR-4730 can be obtained by the method described above. The miRBase Accession No. 10002666666 (hsa-mir-4730) has a hairpin-like structure. ion No. MI0017367, SEQ ID NO: 271) is known.

[0082] As used herein, "hsa-miR-1307-3p gene" or "hsa-mi The term "miR-1307-3p" refers to hsa-miR-1307-3p as set forth in SEQ ID NO: 3. p gene (miRBase Accession No. MIMAT0005951) It also includes homologs or orthologs from other species. 3p genes are Morin RD et al., 2008, Genome Res, Vol. 18, p. 6 The miR-1 gene can be obtained by the method described in 10-621. 307-3p is a precursor of hsa-mir-1307, which has a hairpin-like structure. ” (miRBase Accession No. MI0006444, SEQ ID NO: 272 ) is known.

[0083] As used herein, "hsa-miR-4634 gene" or "hsa-miR-4 The term "miR-4634" refers to the hsa-miR-4634 gene (miRB) set forth in SEQ ID NO: 4. ase Accession No. MIMAT0019691) and other species homologues The hsa-miR-4634 gene is a member of the Perss On H et al., 2011, Cancer Res, Vol. 71, p. 78-86 hsa-miR-4634 can be obtained by the method described above. The miRBase Accession No. 100002666666 forms a hairpin-like structure. ion No. MI0017261, SEQ ID NO: 273) is known.

[0084] As used herein, "hsa-miR-663a gene" or "hsa-miR-6 The term "miR-663a" refers to the hsa-miR-663a gene (miRB) set forth in SEQ ID NO: 5. ase Accession No. MIMAT0003326) and other species homologues The hsa-miR-663a gene is a Cummi ns JM et al., 2006, Proc Natl Acad Sci USA, 10 It can be obtained by the method described in Vol. 3, pp. 3687-3692. a-miR-663a has a hairpin-like structure as its precursor, hsa-mir- 663a" (miRBase Accession No. MI0003672, sequence no. No. 274) is known.

[0085] As used herein, "hsa-miR-4532 gene" or "hsa-miR-4 The term "miR-4532" refers to the hsa-miR-4532 gene (miRB) set forth in SEQ ID NO: 6. ase Accession No. MIMAT0019071) and other species homologues The hsa-miR-4532 gene is a member of the Jima According to the method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 In addition, "hsa-miR-4532" can be obtained by The pin-like structure of "hsa-mir-4532" (miRBase Accession No. No. MI0016899, SEQ ID NO: 275) is known.

[0086] As used herein, "hsa-miR-7704 gene" or "hsa-miR-7 The term "miR-7704" refers to the hsa-miR-7704 gene (miRB) set forth in SEQ ID NO: 7. ase Accession No. MIMAT0030019) and other species homologues The hsa-miR-7704 gene is a member of the Swami Nathan S et al., 2013, Biochem Biophys Res Comm It can be obtained by the method described in Vol. 434, pp. 228-234. "hsa-miR-7704" is a precursor of "hsa-m" which has a hairpin-like structure. ir-7704” (miRBase Accession No. MI0025240, SEQ ID NO: 276) is known.

[0087] As used herein, "hsa-miR-3178 gene" or "hsa-miR-3 The term "miR-3178" refers to the hsa-miR-3178 gene (miRB1) set forth in SEQ ID NO: 8. ase Accession No. MIMAT0015055) and other species homologues The hsa-miR-3178 gene is a member of the Stark By the method described in MS et al., 2010, PLoS One, Vol. 5, e9685 Furthermore, "hsa-miR-3178" can be obtained by using a hairpin The miRBase Accession No. 10000126637 has a similar structure to "hsa-mir-3178" (miRBase Accession No. 10000126637). o.MI0014212, sequence number 277) is known.

[0088] As used herein, "hsa-miR-6729-5p gene" or "hsa-mi The term "miR-6729-5p" refers to hsa-miR-6729-5p as set forth in SEQ ID NO: 9. p gene (miRBase Accession No. MIMAT0027359) It also includes homologs or orthologs from other species. The 5p gene is Ladewig E et al., 2012, Genome Res, vol. 22, p. It can be obtained by the method described in 1634-1645. R-6729-5p is a precursor of hsa-mir-6, which has a hairpin-like structure. 729" (miRBase Accession No. MI0022574, SEQ ID NO: 278) is known.

[0089] As used herein, "hsa-miR-6090 gene" or "hsa-miR-6 The term "miR-6090" refers to the hsa-miR-6090 gene (miR-6090) set forth in SEQ ID NO: 10. Base Accession No. MIMAT0023715) and other species of Homo sapiens The hsa-miR-6090 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev, Vol. 21, pp. 2049-2057 hsa-miR-6090 can be obtained by the method described in The precursor of the hairpin-like structure "hsa-mir-6090" (miRBase Accession No. MI0020367, SEQ ID NO: 279) is known.

[0090] As used herein, "hsa-miR-4732-5p gene" or "hsa-mi The term "miR-4732-5p" refers to hsa-miR-4732-5p as set forth in SEQ ID NO: 11. 5p gene (miRBase Accession No. MIMAT0019855) hsa-miR-4732 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 732-5p has a hairpin-like structure as its precursor, hsa-mir-4732 ” (miRBase Accession No. MI0017369, SEQ ID NO: 280 ) is known.

[0091] As used herein, "hsa-miR-3184-5p gene" or "hsa-mi The term "hsa-miR-3184-5p" refers to hsa-miR-3184- 5p gene (miRBase Accession No. MIMAT0015064) hsa-miR-3184 and other species homologs or orthologs. -5p gene is Stark MS et al., 2010, PLoS One, Vol. 5, e968 5. Also, "hsa-miR-3184-5 p” has a hairpin-like structure as its precursor “hsa-mir-3184” (miR Base Accession No. MI0014226, SEQ ID NO: 281) is known are.

[0092] As used herein, "hsa-miR-6727-5p gene" or "hsa-mi The term "miR-6727-5p" refers to hsa-miR-6727-5p as set forth in SEQ ID NO: 13. 5p gene (miRBase Accession No. MIMAT0027355) hsa-miR-6727 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6727-5p is a precursor of the hairpin-like structure known as hsa-mir- 6727" (miRBase Accession No. MI0022572, sequence no. No. 282) is known.

[0093] As used herein, "hsa-miR-6088 gene" or "hsa-miR-6 The term "miR-6088" refers to the hsa-miR-6088 gene (miR-6088) set forth in SEQ ID NO: 14. Base Accession No. MIMAT0023713) and other species of Homo sapiens The hsa-miR-6088 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev, Vol. 21, pp. 2049-2057 hsa-miR-6088 can be obtained by the method described in The precursor of the hairpin-like structure "hsa-mir-6088" (miRBase Accession No. MI0020365, SEQ ID NO: 283) is known.

[0094] As used herein, "hsa-miR-4674 gene" or "hsa-miR-4 The term "miR-4674" refers to the hsa-miR-4674 gene (miR Base Accession No. MIMAT0019756) and other species of Homo sapiens The hsa-miR-4674 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4674 can be obtained by the method described above. The miRBase Accession No. 1000012666666 forms a hairpin-like structure. sion No. MI0017305, sequence number 284) is known.

[0095] As used herein, "hsa-miR-8073 gene" or "hsa-miR-8 The term "miR-8073" refers to the hsa-miR-8073 gene (miR-8073) set forth in SEQ ID NO: 16. Base Accession No. MIMAT0031000) and other species of Homo sapiens The hsa-miR-8073 gene includes genes encoding miR-8073, such as miR-1 and miR-2, and miR-3 and miR-4. HJ et al., 2013, Shock, Vol. 39, p. 480-487 Furthermore, "hsa-miR-8073" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664444422444 has a miR-like structure. No. MI0025909, SEQ ID NO: 285) is known.

[0096] As used herein, "hsa-miR-4787-5p gene" or "hsa-mi The term "miR-4787-5p" refers to hsa-miR-4787- 5p gene (miRBase Accession No. MIMAT0019956) hsa-miR-4787 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 787-5p has a hairpin-like structure as its precursor, hsa-mir-4787 ” (miRBase Accession No. MI0017434, SEQ ID NO: 286 ) is known.

[0097] As used herein, "hsa-miR-1469 gene" or "hsa-miR-1 The term "miR-1469" refers to the hsa-miR-1469 gene (miR Base Accession No. MIMAT0007347) and other species of Homo sapiens The hsa-miR-1469 gene is a member of the Kawa The method described in Ji H et al., 2008, BMC Genomics, Vol. 9, p. 157 Furthermore, "hsa-miR-1469" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-1469" (miRBase Accession No. on No. MI0007074, SEQ ID NO: 287) is known.

[0098] As used herein, "hsa-miR-125a-3p gene" or "hsa-mi The term "hsa-miR-125a-3p" refers to hsa-miR-125a-3p as set forth in SEQ ID NO: 19. 3p gene (miRBase Accession No. MIMAT0004602) hsa-miR-125a and other species homologs or orthologs. The -3p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. It can be obtained by the method described in "H sa-miR-125a-3p is a precursor of the hairpin-like structure hsa- mir-125a” (miRBase Accession No. MI0000469 , SEQ ID NO: 288) is known.

[0099] As used herein, "hsa-miR-1233-5p gene" or "hsa-mi The term "hsa-miR-1233-5p" refers to hsa-miR-1233- 5p gene (miRBase Accession No. MIMAT0022943) hsa-miR-1233 and other species homologs or orthologs. -5p gene, Berezikov E et al., 2007, Mol Cell, vol. 28, The miR gene can be obtained by the method described on pages 328-336. -1233-5p is a precursor of hsa-mir-12, which has a hairpin-like structure. 33-1, hsa-mir-1233-2” (miRBase Accession N o.MI0006323, MI0015973, SEQ ID NOs: 289, 290) are known do.

[0100] As used herein, "hsa-miR-885-3p gene" or "hsa-miR The term "miR-885-3p" refers to the hsa-miR-885-3p gene set forth in SEQ ID NO: 21. gene (miRBase Accession No. MIMAT0004948) and its This includes homologs or orthologs from other species. Gene: Berezikov E et al., 2006, Genome Res, vol. 16, p. 1 The hsa-miR can be obtained by the method described in -885-3p is a precursor of hsa-mir-885, which has a hairpin-like structure. ” (miRBase Accession No. MI0005560, SEQ ID NO: 291 ) is known.

[0101] As used herein, "hsa-miR-6802-5p gene" or "hsa-mi The term "miR-6802-5p" refers to hsa-miR-6802-5p as set forth in SEQ ID NO: 22. 5p gene (miRBase Accession No. MIMAT0027504) hsa-miR-6802 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6802-5p is a precursor of the hairpin-like structure known as hsa-mir- 6802" (miRBase Accession No. MI0022647, sequence no. No. 292) is known.

[0102] As used herein, "hsa-miR-328-5p gene" or "hsa-miR The term "miR-328-5p" refers to the hsa-miR-328-5p gene set forth in SEQ ID NO: 23. gene (miRBase Accession No. MIMAT0026486) and its This includes homologs or orthologs from other species. The gene is Kim J et al., 2004, Proc Natl Acad Sci US A, Vol. 101, pp. 360-365. hsa-miR-328-5p is a precursor of hsa- mir-328” (miRBase Accession No. MI0000804, SEQ ID NO: 293) is known.

[0103] As used herein, "hsa-miR-6787-5p gene" or "hsa-mi The term "miR-6787-5p" refers to hsa-miR-6787- 5p gene (miRBase Accession No. MIMAT0027474) hsa-miR-6787 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6787-5p is a precursor of the hairpin-like structure known as hsa-mir- 6787" (miRBase Accession No. MI0022632, sequence no. No. 294) is known.

[0104] As used herein, "hsa-miR-8069 gene" or "hsa-miR-8 The term "miR-8069" refers to the hsa-miR-8069 gene (miR Base Accession No. MIMAT0030996) and other species of Homo sapiens The hsa-miR-8069 gene includes miR-logs, miR-1 and miR-2, and miR-3 and miR-4. HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8069" can be obtained by using hairpin as its precursor. The miRBase Accession No. 10000126 ... No. MI0025905, SEQ ID NO: 295) is known.

[0105] As used herein, "hsa-miR-6875-5p gene" or "hsa-mi The term "miR-6875-5p" refers to hsa-miR-6875- 5p gene (miRBase Accession No. MIMAT0027650) hsa-miR-6875 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6875-5p is a precursor of the hairpin-like structure known as hsa-mir- 6875" (miRBase Accession No. MI0022722, sequence no. No. 296) is known.

[0106] As used herein, "hsa-miR-1246 gene" or "hsa-miR-1 The term "miR-1246" refers to the hsa-miR-1246 gene (miR Base Accession No. MIMAT0005898) and other species of Homo sapiens The hsa-miR-1246 gene is a member of the Mori n RD et al., 2008, Genome Res, Vol. 18, p610-621 Furthermore, "hsa-miR-1246" can be obtained by the method described above. The miRBase Accession No. 1246 (hsa-mir-1246) has a hairpin-like structure. The sequence number of the gene encoding the nucleotide sequence of the present invention is 297 (sequence number MI0006381).

[0107] As used herein, "hsa-miR-4734 gene" or "hsa-miR-4 The term "miR-4734" refers to the hsa-miR-4734 gene (miR Base Accession No. MIMAT0019859) and other species of Homo sapiens The hsa-miR-4734 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4734 can be obtained by the method described above. The miRBase Accession No. 100001266666, which has a hairpin-like structure, is a missense mutation called "hsa-mir-4734" (miRBase Accession No. 100001266666666). sion No. MI0017371, SEQ ID NO: 298) is known.

[0108] As used herein, "hsa-miR-6757-5p gene" or "hsa-mi The term "miR-6757-5p" refers to hsa-miR-6757-5p as set forth in SEQ ID NO: 29. 5p gene (miRBase Accession No. MIMAT0027414) hsa-miR-6757 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6757-5p is a precursor of the hairpin-like structure known as hsa-mir- 6757" (miRBase Accession No. MI0022602, sequence no. No. 299) is known.

[0109] As used herein, "hsa-miR-6756-5p gene" or "hsa-mi The term "miR-6756-5p" refers to hsa-miR-6756-5p as set forth in SEQ ID NO: 30. 5p gene (miRBase Accession No. MIMAT0027412) and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6756-5p is a precursor of the hairpin-like structure known as hsa-mir- 6756" (miRBase Accession No. MI0022601, sequence no. No. 300) is known.

[0110] As used herein, "hsa-miR-3665 gene" or "hsa-miR-3 The term "miR-3665" refers to the hsa-miR-3665 gene (miR Base Accession No. MIMAT0018087) and other species of Homo sapiens The hsa-miR-3665 gene is involved in the regulation of Xie X et al., 2005, Nature, Vol. 434, pp. 338-345. In addition, "hsa-miR-3665" can be obtained by using hairpin as its precursor. The miRBase Accession No. 1000012665 ​​(hsa-mir-3665) has a phosphodiesterase-like structure. No. MI0016066, SEQ ID NO: 301) is known.

[0111] As used herein, the term "hsa-miR-6836-3p gene" or "hsa-mi The term "miR-6836-3p" refers to hsa-miR-6836-3p as set forth in SEQ ID NO: 32. 3p gene (miRBase Accession No. MIMAT0027575) hsa-miR-6836 and other species homologs or orthologs. -3p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6836-3p is a precursor of the hairpin-like structure hsa-mir- 6836" (miRBase Accession No. MI0022682, sequence no. No. 302) is known.

[0112] As used herein, "hsa-miR-6821-5p gene" or "hsa-mi The term "miR-6821-5p" refers to hsa-miR-6821-5p as set forth in SEQ ID NO: 33. 5p gene (miRBase Accession No. MIMAT0027542) hsa-miR-6821 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6821-5p is a precursor of the hairpin-like structure known as hsa-mir- 6821" (miRBase Accession No. MI0022666, sequence no. No. 303) is known.

[0113] As used herein, "hsa-miR-6805-5p gene" or "hsa-mi The term "miR-6805-5p" refers to hsa-miR-6805-5p as set forth in SEQ ID NO: 34. 5p gene (miRBase Accession No. MIMAT0027510) hsa-miR-6805 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6805-5p is a precursor of the hairpin-like structure known as hsa-mir- 6805" (miRBase Accession No. MI0022650, sequence no. No. 304) is known.

[0114] As used herein, "hsa-miR-4728-5p gene" or "hsa-mi The term "miR-4728-5p" refers to hsa-miR-4728-5p as set forth in SEQ ID NO: 35. 5p gene (miRBase Accession No. MIMAT0019849) hsa-miR-4728 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 728-5p is a precursor of hsa-mir-4728, which has a hairpin-like structure. ” (miRBase Accession No. MI0017365, SEQ ID NO: 305 ) is known.

[0115] As used herein, "hsa-miR-6726-5p gene" or "hsa-mi The term "miR-6726-5p" refers to hsa-miR-6726-5p as set forth in SEQ ID NO: 36. 5p gene (miRBase Accession No. MIMAT0027353) hsa-miR-6726 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6726-5p is a precursor of the hairpin-like structure known as hsa-mir- 6726" (miRBase Accession No. MI0022571, sequence no. No. 306) is known.

[0116] As used herein, "hsa-miR-197-5p gene" or "hsa-miR The term "miR-197-5p" refers to the hsa-miR-197-5p gene set forth in SEQ ID NO: 37. gene (miRBase Accession No. MIMAT0022691) and its This includes homologs or orthologs from other species. The gene is Lagos-Quintana M et al., 2003, RNA, vol. 9, p175- 179. 5p” has a hairpin-like structure as its precursor “hsa-mir-197” (miR Base Accession No. MI0000239, SEQ ID NO: 307) is known are.

[0117] As used herein, "hsa-miR-149-3p gene" or "hsa-miR The term "miR-149-3p" refers to the hsa-miR-149-3p gene set forth in SEQ ID NO: 38. gene (miRBase Accession No. MIMAT0004609) and its This includes homologs or orthologs from other species. The gene is from Lagos-Quintana M et al., 2002, Curr Biol, 12 It can be obtained by the method described in Vol. 1, pp. 735-739. iR-149-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 49" (miRBase Accession No. MI0000478, SEQ ID NO: 3 08) is known.

[0118] As used herein, "hsa-miR-6850-5p gene" or "hsa-mi The term "miR-6850-5p" refers to hsa-miR-6850-5p as set forth in SEQ ID NO: 39. 5p gene (miRBase Accession No. MIMAT0027600) hsa-miR-6850 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6850-5p is a precursor of the hairpin-like structure known as hsa-mir- 6850" (miRBase Accession No. MI0022696, sequence no. No. 309) is known.

[0119] As used herein, "hsa-miR-4476 gene" or "hsa-miR-4 The term "miR-4476" refers to the hsa-miR-4476 gene (miR Base Accession No. MIMAT0019003) and other species of Homo sapiens The hsa-miR-4476 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4476 can be obtained by The miRBase Accession No. hsa-mir-4476 (hsa-mir-4476) has an apin-like structure. n No. MI0016828, SEQ ID NO: 310) is known.

[0120] As used herein, "hsa-miR-6858-5p gene" or "hsa-mi The term "miR-6858-5p" refers to hsa-miR-6858-5p as set forth in SEQ ID NO: 41. 5p gene (miRBase Accession No. MIMAT0027616) and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6858-5p is a precursor of the hairpin-like structure known as hsa-mir- 6858" (miRBase Accession No. MI0022704, sequence no. No. 311) is known.

[0121] As used herein, "hsa-miR-564 gene" or "hsa-miR-56 The term "miR-564" refers to the hsa-miR-564 gene (miRBas) set forth in SEQ ID NO: 42. e Accession No. MIMAT0003228) and homologs in other species The hsa-miR-564 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103, It can be obtained by the method described in pp. 3687-3692. iR-564 has a precursor called hsa-mir-564, which has a hairpin-like structure. (miRBase Accession No. MI0003570, SEQ ID NO: 312) is known.

[0122] As used herein, "hsa-miR-4763-3p gene" or "hsa-mi The term "miR-4763-3p" refers to hsa-miR-4763-3p as set forth in SEQ ID NO: 43. 3p gene (miRBase Accession No. MIMAT0019913) hsa-miR-4763 and other species homologs or orthologs. -3p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 763-3p is a precursor of hsa-mir-4763, which has a hairpin-like structure. ” (miRBase Accession No. MI0017404, SEQ ID NO: 313 ) is known.

[0123] As used herein, "hsa-miR-575 gene" or "hsa-miR-57 The term "miR-575" refers to the hsa-miR-575 gene (miRBas) set forth in SEQ ID NO: 44. e Accession No. MIMAT0003240) and homologs in other species The hsa-miR-575 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103, It can be obtained by the method described in pp. 3687-3692. iR-575 has a precursor called hsa-mir-575, which has a hairpin-like structure. (miRBase Accession No. MI0003582, SEQ ID NO: 314) is known.

[0124] As used herein, "hsa-miR-6771-5p gene" or "hsa-mi The term "miR-6771-5p" refers to hsa-miR-6771-5p as set forth in SEQ ID NO: 45. 5p gene (miRBase Accession No. MIMAT0027442) hsa-miR-6771 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6771-5p is a precursor of the hairpin-like structure known as hsa-mir- 6771" (miRBase Accession No. MI0022616, sequence no. No. 315) is known.

[0125] As used herein, "hsa-miR-1231 gene" or "hsa-miR-1 The term "miR-1231" refers to the hsa-miR-1231 gene (miR Base Accession No. MIMAT0005586) and other species of Homo sapiens The hsa-miR-1231 gene is a gene encoding a miR-1231 gene. Zikov E et al., 2007, Mol Cell, vol. 28, p328-336 hsa-miR-1231 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure called "hsa-mir-1231" ( Session No. MI0006321, SEQ ID NO: 316) is known.

[0126] As used herein, "hsa-miR-1908-3p gene" or "hsa-mi The term "hsa-miR-1908-3p" refers to hsa-miR-1908- 3p gene (miRBase Accession No. MIMAT0026916) hsa-miR-1908 and other species homologs or orthologs. -3p gene is Bar M et al., 2008, Stem Cells, Vol. 26, p. 249 The miR-1 gene can be obtained by the method described in JP-A-2006-2505. 908-3p is a precursor of hsa-mir-1908, which has a hairpin-like structure. ” (miRBase Accession No. MI0008329, SEQ ID NO: 317 ) is known.

[0127] As used herein, "hsa-miR-150-3p gene" or "hsa-miR The term "miR-150-3p" refers to the hsa-miR-150-3p gene set forth in SEQ ID NO: 48. gene (miRBase Accession No. MIMAT0004610) and its This includes homologs or orthologs from other species. The gene is from Lagos-Quintana M et al., 2002, Curr Biol, 12 It can be obtained by the method described in Vol. 1, pp. 735-739. iR-150-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 50" (miRBase Accession No. MI0000479, SEQ ID NO: 3 18) is known.

[0128] As used herein, "hsa-miR-3937 gene" or "hsa-miR-3 The term "miR-3937" refers to the hsa-miR-3937 gene (miR Base Accession No. MIMAT0018352) and other species of Homo sapiens The hsa-miR-3937 gene is a member of the Liao JY et al., 2010, PLoS One, Vol. 5, e10563 In addition, "hsa-miR-3937" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266344444 has a phosphodiesterase-like structure, "hsa-mir-3937" (miRBase Accession No. 1000012663444444). No. MI0016593, SEQ ID NO: 319) is known.

[0129] As used herein, "hsa-miR-887-3p gene" or "hsa-miR The term "miR-887-3p" refers to the hsa-miR-887-3p gene set forth in SEQ ID NO: 50. gene (miRBase Accession No. MIMAT0004951) and its This includes homologs or orthologs from other species. Gene: Berezikov E et al., 2006, Genome Res, vol. 16, p. 1 The hsa-miR can be obtained by the method described in -887-3p is a precursor of hsa-mir-887, which has a hairpin-like structure. ” (miRBase Accession No. MI0005562, SEQ ID NO: 320 ) is known.

[0130] As used herein, "hsa-miR-3940-5p gene" or "hsa-mi The term "hsa-miR-3940-5p" refers to hsa-miR-3940- 5p gene (miRBase Accession No. MIMAT0019229) and other species homologs or orthologs. -5p gene, Liao JY et al., 2010, PLoS One, Vol. 5, e1056 The miR-3940-5 gene can be obtained by the method described in 3. p” has a hairpin-like structure as its precursor “hsa-mir-3940” (miR Base Accession No. MI0016597, SEQ ID NO: 321) is known are.

[0131] As used herein, "hsa-miR-4741 gene" or "hsa-miR-4 The term "miR-4741" refers to the hsa-miR-4741 gene (miR-4741) set forth in SEQ ID NO: 52. Base Accession No. MIMAT0019871) and other species of Homo sapiens The hsa-miR-4741 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4741 can be obtained by the method described above. The miRBase Accession No. 10 ... sion No. MI0017379, SEQ ID NO: 322) is known.

[0132] As used herein, "hsa-miR-6808-5p gene" or "hsa-mi The term "miR-6808-5p" refers to hsa-miR-6808-5p as set forth in SEQ ID NO: 53. 5p gene (miRBase Accession No. MIMAT0027516) and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6808-5p is a precursor of the hairpin-like structure known as hsa-mir- 6808" (miRBase Accession No. MI0022653, sequence no. No. 323) is known.

[0133] As used herein, "hsa-miR-6869-5p gene" or "hsa-mi The term "miR-6869-5p" refers to hsa-miR-6869-5p as set forth in SEQ ID NO: 54. 5p gene (miRBase Accession No. MIMAT0027638) hsa-miR-6869 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6869-5p is a precursor of the hairpin-like structure known as hsa-mir- 6869" (miRBase Accession No. MI0022716, sequence no. No. 324) is known.

[0134] As used herein, "hsa-miR-5090 gene" or "hsa-miR-5 The term "miR-5090" refers to the hsa-miR-5090 gene (miR Base Accession No. MIMAT0021082) and other species of Homo sapiens The hsa-miR-5090 gene is a Ding N et al., 2011, J Radiat Res, Vol. 52, p. 425-432 Furthermore, "hsa-miR-5090" can be obtained by the method described above. The miRBase Accession No. 10002666664 (hsa-mir-5090) has a hairpin-like structure as a The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0017979, sequence number 325.

[0135] As used herein, "hsa-miR-615-5p gene" or "hsa-miR The term "miR-615-5p" refers to the hsa-miR-615-5p gene set forth in SEQ ID NO: 56. gene (miRBase Accession No. MIMAT0004804) and its This includes homologs or orthologs from other species. The gene is described in Cummins JM et al., 2006, Proc Natl Acad Sci It can be obtained by the method described in USA, Vol. 103, pp. 3687-3692. In addition, "hsa-miR-615-5p" has a hairpin-like structure as its precursor. Take "hsa-mir-615" (miRBase Accession No. MI0 003628, SEQ ID NO: 326) is known.

[0136] As used herein, "hsa-miR-8072 gene" or "hsa-miR-8 The term "miR-8072" refers to the hsa-miR-8072 gene (miR-8072) set forth in SEQ ID NO: 57. Base Accession No. MIMAT0030999) and other species of Homo sapiens The hsa-miR-8072 gene includes genes encoding miR-1 and miR-2, and ...2 and miR-3, and includes genes encoding miR-1 and miR-4, and includes genes encoding miR-2 and miR-5, and includes genes encoding miR-1 and miR-6, and includes genes encoding miR-1 and miR-4, and includes genes encoding miR-1 and miR-5, and includes genes encoding HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8072" can be obtained by using hairpin as its precursor. The miRBase Accession No. 1000012444444444 has a miR-like structure. No. MI0025908, SEQ ID NO: 327) is known.

[0137] As used herein, "hsa-miR-128-1-5p gene" or "hsa-m The term "miR-128-1-5p" refers to hsa-miR-128 as set forth in SEQ ID NO: 58. -1-5p gene (miRBase Accession No. MIMAT00264 77) and other species homologs or orthologs. The 28-1-5p gene is described in Lagos-Quintana M et al., 2002, Curr It can be obtained by the method described in Biol, Vol. 12, pp. 735-739. In addition, "hsa-miR-128-1-5p" has a hairpin-like structure as its precursor. "hsa-mir-128-1" (miRBase Accession No.MI0 000447, SEQ ID NO: 328) is known.

[0138] As used herein, "hsa-miR-1238-5p gene" or "hsa-mi The term "miR-1238-5p" refers to hsa-miR-1238-5p as set forth in SEQ ID NO: 59. 5p gene (miRBase Accession No. MIMAT0022947) hsa-miR-1238 and other species homologs or orthologs. -5p gene, Berezikov E et al., 2007, Mol Cell, vol. 28, The miR gene can be obtained by the method described on pages 328-336. -1238-5p is a precursor of hsa-mir-12, which has a hairpin-like structure. 38" (miRBase Accession No. MI0006328, SEQ ID NO: 3 29) is known.

[0139] As used herein, "hsa-miR-365a-5p gene" or "hsa-mi The term "hsa-miR-365a-5p" refers to hsa-miR-365a-5p as set forth in SEQ ID NO: 60. 5p gene (miRBase Accession No. MIMAT0009199) hsa-miR-365a and other species homologs or orthologs. The -5p gene is described in Xie X et al., 2005, Nature, Vol. 434, p. 338-34. 5. Also, "hsa-miR-365a-5" can be obtained by the method described in p” has a hairpin-like structure as its precursor “hsa-mir-365a” (miR Base Accession No. MI0000767, SEQ ID NO: 330) is known are.

[0140] As used herein, "hsa-miR-204-3p gene" or "hsa-miR The term "miR-204-3p" refers to the hsa-miR-204-3p gene set forth in SEQ ID NO: 61. gene (miRBase Accession No. MIMAT0022693) and its This includes homologs or orthologs from other species. The gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. Furthermore, "hsa-miR-204-3p" can be obtained by the method described above. The precursor "hsa-mir-204" (miRBase Ac Accession No. MI0000284, SEQ ID NO: 331) is known.

[0141] As used herein, "hsa-miR-4492 gene" or "hsa-miR-4 The term "miR-4492" refers to the hsa-miR-4492 gene (miR Base Accession No. MIMAT0019027) and other species of Homo sapiens The hsa-miR-4492 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4492 can be obtained as a precursor of The miRBase Accession No. 1244492 (hsa-mir-4492) has an apin-like structure. n No. MI0016854, sequence number 332) is known.

[0142] As used herein, "hsa-miR-6785-5p gene" or "hsa-mi The term "miR-6785-5p" refers to hsa-miR-6785- 5p gene (miRBase Accession No. MIMAT0027470) hsa-miR-6785 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6785-5p is a precursor of the hairpin-like structure known as hsa-mir- 6785" (miRBase Accession No. MI0022630, sequence no. No. 333) is known.

[0143] As used herein, "hsa-miR-6511a-5p gene" or "hsa-m The term "hsa-miR-6511a-5p" refers to hsa-miR-6511a-5p as set forth in SEQ ID NO: 64. 1a-5p gene (miRBase Accession No. MIMAT00254 78) and other species homologs or orthologs. The 511a-5p gene is described in Joyce CE et al., 2011, Hum Mol Gene It can be obtained by the method described in Vol. 20, pp. 4025-4040. "hsa-miR-6511a-5p" is a precursor of "hsa-miR-6511a-5p" which has a hairpin-like structure. sa-mir-6511a-1, hsa-mir-6511a-2, hsa-mir-6 511a-3, hsa-mir-6511a-4” (miRBase Accessio n No.MI0022223, MI0023564, MI0023565, MI002 3566, SEQ ID NOs: 334, 335, 336, 337) are known.

[0144] As used herein, "hsa-miR-4525 gene" or "hsa-miR-4 The term "miR-4525" refers to the hsa-miR-4525 gene (miR Base Accession No. MIMAT0019064) and other species of Homo sapiens The hsa-miR-4525 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4525 can be obtained as a precursor of The miRBase Accession No. hsa-mir-4525 (hsa-mir-4525) has an apin-like structure. n No. MI0016892, sequence number 338) is known.

[0145] As used herein, "hsa-miR-1915-5p gene" or "hsa-mi The term "hsa-miR-1915-5p" refers to hsa-miR-1915- 5p gene (miRBase Accession No. MIMAT0007891) hsa-miR-1915 and other species homologs or orthologs. -5p gene is Bar M et al., 2008, Stem Cells, Vol. 26, p. 249 The miR-1 gene can be obtained by the method described in JP-A-2006-2505. 915-5p is a precursor of hsa-mir-1915, which has a hairpin-like structure. ” (miRBase Accession No. MI0008336, SEQ ID NO: 339 ) is known.

[0146] As used herein, "hsa-miR-3180 gene" or "hsa-miR-3 The term "miR-3180" refers to the hsa-miR-3180 gene (miR-3180) set forth in SEQ ID NO: 67. Base Accession No. MIMAT0018178) and other species of Homo sapiens The hsa-miR-3180 gene is a gene encoding a miR-3180 gene. As described in ghton CJ et al., 2010, PLoS One, Vol. 5, e9637 hsa-miR-3180 can be obtained by the method described above. The hairpin-like structures of "hsa-mir-3180-4, hsa-mir-3180- 5” (miRBase Accession No. MI0016408, MI0016 409, SEQ ID NOs: 340 and 341) are known.

[0147] As used herein, "hsa-miR-6879-5p gene" or "hsa-mi The term "miR-6879-5p" refers to hsa-miR-6879-5p as set forth in SEQ ID NO: 68. 5p gene (miRBase Accession No. MIMAT0027658) hsa-miR-6879 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6879-5p is a precursor of the hairpin-like structure known as hsa-mir- 6879" (miRBase Accession No. MI0022726, sequence no. No. 342) is known.

[0148] As used herein, "hsa-miR-1199-5p gene" or "hsa-mi The term "hsa-miR-1199-5p" refers to hsa-miR-1199-5p as set forth in SEQ ID NO: 69. 5p gene (miRBase Accession No. MIMAT0031119) hsa-miR-1199 and other species homologs or orthologs. -5p gene is Salvi A et al., 2013, Int J Oncol, vol. 42, p. The "hsa-miR- 1199-5p is a precursor of hsa-mir-119, which has a hairpin-like structure. 9" (miRBase Accession No. MI0020340, SEQ ID NO: 34 3) is known.

[0149] As used herein, "hsa-miR-6746-5p gene" or "hsa-mi The term "miR-6746-5p" refers to hsa-miR-6746-5p as set forth in SEQ ID NO: 70. 5p gene (miRBase Accession No. MIMAT0027392) and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6746-5p is a precursor of the hairpin-like structure known as hsa-mir- 6746" (miRBase Accession No. MI0022591, sequence no. No. 344) is known.

[0150] As used herein, "hsa-miR-711 gene" or "hsa-miR-71 The term "miR-711" refers to the hsa-miR-711 gene (miRBas) set forth in SEQ ID NO: 71. e Accession No. MIMAT0012734) and homologs in other species The hsa-miR-711 gene is described by Artzi S et al. , 2008, BMC Bioinformatics, Vol. 9, p. 39 hsa-miR-711 can be obtained by The apin-like structure of "hsa-mir-711" (miRBase Accession No. No. MI0012488, SEQ ID NO: 345) is known.

[0151] As used herein, "hsa-miR-663b gene" or "hsa-miR-6 The term "miR-663b" refers to the hsa-miR-663b gene (miR Base Accession No. MIMAT0005867) and other species of Homo sapiens The hsa-miR-663b gene is a member of the Taka da S et al., 2008, Leukemia, Vol. 22, p. 1274-1278 hsa-miR-663b can be obtained by the method described above. The miRBase Accession No. 1000012666444444444 is a miR-based gene that has a hairpin-like structure. The sequence number of the nucleotide sequence ...

[0152] As used herein, "hsa-miR-4707-3p gene" or "hsa-mi The term "miR-4707-3p" refers to hsa-miR-4707-3p as set forth in SEQ ID NO: 73. 3p gene (miRBase Accession No. MIMAT0019808) hsa-miR-4707 and other species homologs or orthologs. -3p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 707-3p is a precursor of hsa-mir-4707, which has a hairpin-like structure. ” (miRBase Accession No. MI0017340, SEQ ID NO: 347 ) is known.

[0153] As used herein, "hsa-miR-6893-5p gene" or "hsa-mi The term "miR-6893-5p" refers to hsa-miR-6893-5p as set forth in SEQ ID NO: 74. 5p gene (miRBase Accession No. MIMAT0027686) hsa-miR-6893 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6893-5p is a precursor of the hairpin-like structure known as hsa-mir- 6893" (miRBase Accession No. MI0022740, sequence no. No. 348) is known.

[0154] As used herein, "hsa-miR-4675 gene" or "hsa-miR-4 The term "miR-4675" refers to the hsa-miR-4675 gene (miR Base Accession No. MIMAT0019757) and other species of Homo sapiens The hsa-miR-4675 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4675 can be obtained by the method described above. The miRBase Accession No. 1000012666666644444444 is a miR-based gene that forms a hairpin-like structure. sion No. MI0017306, SEQ ID NO: 349) is known.

[0155] As used herein, "hsa-miR-4638-5p gene" or "hsa-mi The term "miR-4638-5p" refers to hsa-miR-4638-5p as set forth in SEQ ID NO: 76. 5p gene (miRBase Accession No. MIMAT0019695) hsa-miR-4638 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 638-5p has a hairpin-like structure as its precursor, hsa-mir-4638 ” (miRBase Accession No. MI0017265, SEQ ID NO: 350 ) is known.

[0156] As used herein, "hsa-miR-4651 gene" or "hsa-miR-4 The term "miR-4651" refers to the hsa-miR-4651 gene (miR Base Accession No. MIMAT0019715) and other species of Homo sapiens The hsa-miR-4651 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4651 can be obtained by the method described above. The miRBase Accession No. 10 ... sion No. MI0017279, SEQ ID NO: 351) is known.

[0157] As used herein, "hsa-miR-6087 gene" or "hsa-miR-6 The term "miR-6087" refers to the hsa-miR-6087 gene (miR-6087) set forth in SEQ ID NO: 78. Base Accession No. MIMAT0023712) and other species of Homo sapiens The hsa-miR-6087 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev, Vol. 21, pp. 2049-2057 hsa-miR-6087 can be obtained by the method described in The precursor of the hairpin-like structure "hsa-mir-6087" (miRBase Accession No. MI0020364, SEQ ID NO: 352) is known.

[0158] As used herein, "hsa-miR-4665-5p gene" or "hsa-mi The term "miR-4665-5p" refers to hsa-miR-4665-5p as set forth in SEQ ID NO: 79. 5p gene (miRBase Accession No. MIMAT0019739) hsa-miR-4665 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 665-5p has a hairpin-like structure as its precursor, hsa-mir-4665 ” (miRBase Accession No. MI0017295, SEQ ID NO: 353 ) is known.

[0159] As used herein, "hsa-miR-4758-5p gene" or "hsa-mi The term "miR-4758-5p" refers to hsa-miR-4758- 5p gene (miRBase Accession No. MIMAT0019903) hsa-miR-4758 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 758-5p is a precursor of hsa-mir-4758, which has a hairpin-like structure. ” (miRBase Accession No. MI0017399, SEQ ID NO: 354 ) is known.

[0160] As used herein, "hsa-miR-6887-5p gene" or "hsa-mi The term "miR-6887-5p" refers to hsa-miR-6887- 5p gene (miRBase Accession No. MIMAT0027674) hsa-miR-6887 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6887-5p is a precursor of the hairpin-like structure known as hsa-mir- 6887" (miRBase Accession No. MI0022734, sequence no. No. 355) is known.

[0161] As used herein, "hsa-miR-3620-5p gene" or "hsa-mi The term "miR-3620-5p" refers to hsa-miR-3620-5p as set forth in SEQ ID NO: 82. 5p gene (miRBase Accession No. MIMAT0022967) hsa-miR-3620 and other species homologs or orthologs. -5p gene is described in Witten D et al., 2010, BMC Biol, Vol. 8, p58 The "hsa-miR-3620-5p" can be obtained by the method described in the literature. The precursor of miRBa is a hairpin-like structure called "hsa-mir-3620" (miRBa (Accession No. MI0016011, SEQ ID NO: 356) do.

[0162] As used herein, "hsa-miR-1909-3p gene" or "hsa-mi The term "hsa-miR-1909-3p" refers to hsa-miR-1909- 3p gene (miRBase Accession No. MIMAT0007883) hsa-miR-1909 and other species homologs or orthologs. -3p gene is Bar M et al., 2008, Stem Cells, Vol. 26, p. 249 The miR-1 gene can be obtained by the method described in JP-A-2006-2505. 909-3p is a precursor of hsa-mir-1909, which has a hairpin-like structure. ” (miRBase Accession No. MI0008330, SEQ ID NO: 357 ) is known.

[0163] As used herein, "hsa-miR-7641 gene" or "hsa-miR-7 The term "miR-7641" refers to the hsa-miR-7641 gene (miR Base Accession No. MIMAT0029782) and other species of Homo sapiens The hsa-miR-7641 gene is a member of the Yoo JK et al., 2013, Arch Pharm Res, vol. 36, pp. 353-358 hsa-miR-7641 can be obtained by the method described above. The hairpin-like structures of the mercury-containing proteins hsa-mir-7641-1 and hsa-mir-7 641-2” (miRBase Accession No. MI0024975, MI 0024976, SEQ ID NOs: 358, 359) are known.

[0164] As used herein, "hsa-miR-6724-5p gene" or "hsa-mi The term "miR-6724-5p" refers to hsa-miR-6724-5p as set forth in SEQ ID NO: 85. 5p gene (miRBase Accession No. MIMAT0025856) hsa-miR-6724 and other species homologs or orthologs. The -5p gene is described in Li Y et al., 2012, Gene, Vol. 497, p. 330-335. hsa-miR-6724-5p can be obtained by the method described in the literature. , and its precursor, "hsa-mir-6724" (miRBas e Accession No. MI0022559, SEQ ID NO: 360) is known .

[0165] As used herein, "hsa-miR-1343-3p gene" or "hsa-mi The term "hsa-miR-1343-3p" refers to hsa-miR-1343- 3p gene (miRBase Accession No. MIMAT0019776) hsa-miR-1343 and other species homologs or orthologs. -3p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-1 gene can be obtained by the method described on pages 78-86 of this specification. 343-3p has a hairpin-like structure as its precursor, hsa-mir-1343 ” (miRBase Accession No. MI0017320, SEQ ID NO: 361 ) is known.

[0166] As used herein, "hsa-miR-6780b-5p gene" or "hsa-m The term "hsa-miR-6780b-5p" refers to hsa-miR-6780b-5p as set forth in SEQ ID NO: 87. 0b-5p gene (miRBase Accession No. MIMAT00275 72) and other species homologs or orthologs. The 780b-5p gene is from Ladewig E et al., 2012, Genome Res. It can be obtained by the method described in Vol. 22, pp. 1634-1645. sa-miR-6780b-5p has a hairpin-like structure as its precursor, hsa -mir-6780b” (miRBase Accession No. MI00226 81, SEQ ID NO: 362) is known.

[0167] As used herein, "hsa-miR-4484 gene" or "hsa-miR-4 The term "miR-4484" refers to the hsa-miR-4484 gene (miR Base Accession No. MIMAT0019018) and other species of Homo sapiens The hsa-miR-4484 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4484 can be obtained by The miRBase Accession No. 100001266666 (hsa-mir-4484) has an apin-like structure. n No. MI0016845, sequence number 363) is known.

[0168] As used herein, "hsa-miR-4690-5p gene" or "hsa-mi The term "miR-4690-5p" refers to hsa-miR-4690-5p as set forth in SEQ ID NO: 89. 5p gene (miRBase Accession No. MIMAT0019779) hsa-miR-4690 and other species homologs or orthologs. -5p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 690-5p has a hairpin-like structure as its precursor, hsa-mir-4690 ” (miRBase Accession No. MI0017323, SEQ ID NO: 364 ) is known.

[0169] As used herein, "hsa-miR-4429 gene" or "hsa-miR-4 The term "miR-4429" refers to the hsa-miR-4429 gene (miR Base Accession No. MIMAT0018944) and other species of Homo sapiens The hsa-miR-4429 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 Furthermore, hsa-miR-4429 can be obtained as a precursor. The miRBase Accession No. 100001266666 (hsa-mir-4429) has an apin-like structure. n No. MI0016768, sequence number 365) is known.

[0170] As used herein, "hsa-miR-1227-5p gene" or "hsa-mi The term "miR-1227-5p" refers to hsa-miR-1227-5p as set forth in SEQ ID NO: 91. 5p gene (miRBase Accession No. MIMAT0022941) hsa-miR-1227 and other species homologs or orthologs. -5p gene, Berezikov E et al., 2007, Mol Cell, vol. 28, The miR gene can be obtained by the method described on pages 328-336. -1227-5p is a precursor of hsa-mir-12, which has a hairpin-like structure. 27" (miRBase Accession No. MI0006316, SEQ ID NO: 3 66) is known.

[0171] As used herein, "hsa-miR-4725-3p gene" or "hsa-mi The term "miR-4725-3p" refers to hsa-miR-4725-3p as set forth in SEQ ID NO: 92. 3p gene (miRBase Accession No. MIMAT0019844) hsa-miR-4725 and other species homologs or orthologs. -3p gene, Persson H et al., 2011, Cancer Res, vol. 71, The miR-4 gene can be obtained by the method described on pages 78-86 of this specification. 725-3p has a hairpin-like structure as its precursor, hsa-mir-4725 ” (miRBase Accession No. MI0017362, SEQ ID NO: 367 ) is known.

[0172] As used herein, "hsa-miR-6861-5p gene" or "hsa-mi The term "hsa-miR-6861-5p" refers to hsa-miR-6861-5p as set forth in SEQ ID NO: 93. 5p gene (miRBase Accession No. MIMAT0027623) hsa-miR-6861 and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6861-5p is a precursor of the hairpin-like structure known as hsa-mir- 6861" (miRBase Accession No. MI0022708, sequence no. No. 368) is known.

[0173] As used herein, "hsa-miR-6812-5p gene" or "hsa-mi The term "miR-6812-5p" refers to hsa-miR-6812-5p as set forth in SEQ ID NO: 94. 5p gene (miRBase Accession No. MIMAT0027524) and other species homologs or orthologs. -5p gene, Ladewig E et al., 2012, Genome Res, vol. 22, It can be obtained by the method described on pages 1634-1645. iR-6812-5p is a precursor of the hairpin-like structure known as hsa-mir- 6812" (miRBase Accession No. MI0022657, sequence no. No. 369) is known.

[0174] As used herein, "hsa-miR-3197 gene" or "hsa-miR-3 The term "miR-3197" refers to the hsa-miR-3197 gene (miR Base Accession No. MIMAT0015082) and other species of Homo sapiens The hsa-miR-3197 gene is a member of the Star By the method described in k MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3197" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266364444 has a phosphodiesterase-like structure, "hsa-mir-3197" (miRBase Accession No. 100001266364444). No. MI0014245, SEQ ID NO: 370) is known.

[0175] As used herein, "hsa-miR-8059 gene" or "hsa-miR-8 The term "miR-8059" refers to the hsa-miR-8059 gene (miR-8059) set forth in SEQ ID NO: 96. Base Accession No. MIMAT0030986) and other species of Homo sapiens The hsa-miR-8059 gene includes genes encoding miR-8059, such as miR-1 and miR-2, and miR-3 and miR-4. HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8059" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664 (hsa-mir-8059) has a miR-like structure. No. MI0025895, SEQ ID NO: 371) is known.

[0176] As used herein, "hsa-miR-3185 gene" or "hsa-miR-3 The term "miR-3185" refers to the hsa-miR-3185 gene (miR-3185) set forth in SEQ ID NO: 97. Base Accession No. MIMAT0015065) and other species of Homo sapiens The hsa-miR-3185 gene is a member of the Star By the method described in k MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3185" can be obtained by using hairpin as its precursor. The miRBase Accession No. 1000012666666 (hsa-mir-3185) has a miR-like structure. No. MI0014227, SEQ ID NO: 372) is known.

[0177] As used herein, "hsa-miR-4706 gene" or "hsa-miR-4 The term "miR-4706" refers to the hsa-miR-4706 gene (miR Base Accession No. MIMAT0019806) and other species of Homo sapiens The hsa-miR-4706 gene is a member of the Pers Son H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4706 can be obtained by the method described above. The miRBase Accession No. 10000264444444 forms a hairpin-like structure. sion No. MI0017339, SEQ ID NO: 373) is known.

[0178] As used herein, "hsa-miR-4497 gene" or "hsa-miR-4 The term "miR-4497" refers to the hsa-miR-4497 gene (miR Base Accession No. MIMAT0019032) and other species of Homo sapiens The hsa-miR-4497 gene is a member of the Jima The method described in DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4497 can be obtained by The apin-like structure of "hsa-mir-4497" (miRBase Accession No. n No. MI0016859, sequence number 374) is known.

[0179] As used herein, "hsa-miR-3131 gene" or "hsa-miR-3 The term "miR-3131" refers to the hsa-miR-3131 gene (miR-3131) set forth in SEQ ID NO: 100. RBase Accession No. MIMAT0014996) and other species The hsa-miR-3131 gene is a homologue or ortholog of the Sta rk MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3131" can be obtained by The pin-like structure of "hsa-mir-3131" (miRBase Accession No. No. MI0014151, SEQ ID NO: 375) is known.

[0180] As used herein, "hsa-miR-6806-5p gene" or "hsa-mi The term "miR-6806-5p" refers to hsa-miR-6806 as set forth in SEQ ID NO: 101. -5p gene (miRBase Accession No. MIMAT0027512 ) and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6806-5p has a hairpin-like structure as its precursor, hsa-mir -6806" (miRBase Accession No. MI0022651, sequence Number 376) is known.

[0181] As used herein, "hsa-miR-187-5p gene" or "hsa-miR The term "miR-187-5p" refers to hsa-miR-187-5p as set forth in SEQ ID NO: 102. Gene (miRBase Accession No. MIMAT0004561) and It includes homologs or orthologs of other species. The gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. Furthermore, "hsa-miR-187-5p" can be obtained by the method described above. The precursor of the hairpin-like structure "hsa-mir-187" (miRBase A Accession No. MI0000274, SEQ ID NO: 377) is known.

[0182] As used herein, "hsa-miR-3180-3p gene" or "hsa-mi The term "miR-3180-3p" refers to hsa-miR-3180 as set forth in SEQ ID NO: 103. -3p gene (miRBase Accession No. MIMAT0015058 ) and other species homologs or orthologs. The 0-3p gene is Creighton CJ et al., 2010, PLoS One, Vol. 5 The "hsa-miR-3" can be obtained by the method described in e9637. 180-3p has a hairpin-like structure as its precursor, hsa-mir-3180 -1, hsa-mir-3180-2, hsa-mir-3180-3” (miRBas e Accession No. MI0014214, MI0014215, MI001 4217, SEQ ID NOs: 378, 379, 380) are known.

[0183] As used herein, "hsa-miR-6848-5p gene" or "hsa-mi The term "miR-6848-5p" refers to hsa-miR-6848 as set forth in SEQ ID NO: 104. -5p gene (miRBase Accession No. MIMAT0027596 ) and other species homologs or orthologs. The 8-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6848-5p has a hairpin-like structure as its precursor, hsa-mir -6848" (miRBase Accession No. MI0022694, sequence Number 381) is known.

[0184] As used herein, "hsa-miR-6820-5p gene" or "hsa-mi The term "miR-6820-5p" refers to hsa-miR-6820 set forth in SEQ ID NO: 105. -5p gene (miRBase Accession No. MIMAT0027540 ) and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6820-5p has a hairpin-like structure as its precursor, hsa-mir -6820" (miRBase Accession No. MI0022665, sequence Number 382) is known.

[0185] As used herein, "hsa-miR-6800-5p gene" or "hsa-mi The term "miR-6800-5p" refers to the hsa-miR-6800 protein set forth in SEQ ID NO: 106. -5p gene (miRBase Accession No. MIMAT0027500 ) and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6800-5p has a hairpin-like structure as its precursor, hsa-mir -6800" (miRBase Accession No. MI0022645, sequence Number 383) is known.

[0186] As used herein, "hsa-miR-6717-5p gene" or "hsa-mi The term "miR-6717-5p" refers to hsa-miR-6717 set forth in SEQ ID NO: 107. -5p gene (miRBase Accession No. MIMAT0025846 ) and other species homologs or orthologs. The 7-5p gene is described in Li Y et al., 2012, Gene, Vol. 497, p. 330-335. It can be obtained by the method described in the specification. The precursor of miRBa is “hsa-mir-6717” (miRBa (Accession No. MI0022551, SEQ ID NO: 384) do.

[0187] As used herein, "hsa-miR-6795-5p gene" or "hsa-mi The term "miR-6795-5p" refers to hsa-miR-6795 as set forth in SEQ ID NO: 108. -5p gene (miRBase Accession No. MIMAT0027490 ) and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6795-5p has a hairpin-like structure as its precursor, hsa-mir -6795" (miRBase Accession No. MI0022640, sequence Number 385) is known.

[0188] As used herein, "hsa-miR-4632-5p gene" or "hsa-mi The term "miR-4632-5p" refers to hsa-miR-4632 set forth in SEQ ID NO: 109. -5p gene (miRBase Accession No. MIMAT0022977 ) and other species homologs or orthologs. The 2-5p gene is Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4632-5p is a precursor of hsa-mir-463, which has a hairpin-like structure. 2" (miRBase Accession No. MI0017259, SEQ ID NO: 38 6) is known.

[0189] As used herein, "hsa-miR-665 gene" or "hsa-miR-66 The term "miR-665" refers to the hsa-miR-665 gene (miRBa se Accession No. MIMAT0004952) and other species homologs or orthologues thereof. ov E et al., 2006, Genome Res, vol. 16, pp. 1289-1298 Furthermore, "hsa-miR-665" can be obtained by the method described above. The miRBase Accession No. 10000126665 (hsa-mir-665) has a hairpin-like structure as a target. The sequence number of the gene encoding the nucleotide sequence of the present invention is 387 (sequence number MI0005563, sequence number 387).

[0190] As used herein, "hsa-miR-6778-5p gene" or "hsa-mi The term "miR-6778-5p" refers to hsa-miR-6778 as set forth in SEQ ID NO: 111. -5p gene (miRBase Accession No. MIMAT0027456 ) and other species homologs or orthologs. The 8-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6778-5p has a hairpin-like structure as its precursor, hsa-mir -6778" (miRBase Accession No. MI0022623, sequence Number 388) is known.

[0191] As used herein, "hsa-miR-3663-3p gene" or "hsa-mi The term "miR-3663-3p" refers to hsa-miR-3663 as set forth in SEQ ID NO: 112. -3p gene (miRBase Accession No. MIMAT0018085 ) and other species homologs or orthologs. The 3-3p gene is Liao JY et al., 2010, PLoS One, Vol. 5, e105 The miR-3663 can be obtained by the method described in 63. 3p" has a hairpin-like structure as its precursor "hsa-mir-3663" (mi RBase Accession No. MI0016064, sequence number 389) It is being done.

[0192] As used herein, "hsa-miR-4689 gene" or "hsa-miR-4 The term "miR-4689" refers to the hsa-miR-4689 gene (miR-4689) set forth in SEQ ID NO: 113. RBase Accession No. MIMAT0019778) and other species The hsa-miR-4689 gene is a homologue or ortholog of the Per sson H et al., 2011, Cancer Res, Vol. 71, p78-86 Furthermore, "hsa-miR-4689" can be obtained by the method described above. The miRBase Accession No. 10000266666666666665 forms a hairpin-like structure as a target protein. The sequence number of the nucleotide sequence ...

[0193] As used herein, "hsa-miR-211-3p gene" or "hsa-miR The term "miR-211-3p" refers to hsa-miR-211-3p as set forth in SEQ ID NO: 114. Gene (miRBase Accession No. MIMAT0022694) and This includes homologs or orthologs of other species. The gene is described in Lim LP et al., 2003, Science, Vol. 299, p. 1540. Furthermore, "hsa-miR-211-3p" can be obtained by the method described above. The precursor of the hairpin-like structure "hsa-mir-211" (miRBase A Accession No. MI0000287, SEQ ID NO: 391) is known.

[0194] As used herein, "hsa-miR-6511b-5p gene" or "hsa-m The term "miR-6511b-5p" refers to hsa-miR-65 as set forth in SEQ ID NO: 115. 11b-5p gene (miRBase Accession No. MIMAT0025 847) and other species homologs or orthologs. The 6511b-5p gene is described in Li Y et al., 2012, Gene, Vol. 497, p. 330- 335. Also, "hsa-miR-6511" can be obtained by the method described in b-5p is a precursor of hsa-mir-6511b-, which has a hairpin-like structure. 1, hsa-mir-6511b-2” (miRBase Accession No. MI0022552, MI0023431, SEQ ID NOs: 392, 393) are known.

[0195] As used herein, "hsa-miR-4750-5p gene" or "hsa-mi The term "miR-4750-5p" refers to hsa-miR-4750 set forth in SEQ ID NO: 116. -5p gene (miRBase Accession No. MIMAT0019887 ) and other species homologs or orthologs. The 0-5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4750-5p has a hairpin-like structure as its precursor, hsa-mir-475 0" (miRBase Accession No. MI0017389, SEQ ID NO: 39 4) is known.

[0196] As used herein, "hsa-miR-6126 gene" or "hsa-miR-6 The term "miR-6126" refers to the hsa-miR-6126 gene (miR-6126) set forth in SEQ ID NO: 117. RBase Accession No. MIMAT0024599) and other species The hsa-miR-6126 gene is a homologue or ortholog of the Smi th JL et al., 2012, J Virol, Vol. 86, p5278-5287 Furthermore, "hsa-miR-6126" can be obtained by the method described above. The miRBase Accession No. 10000126 (hsa-mir-6126) has a hairpin-like structure as a The sequence number of the nucleotide sequence ...

[0197] As used herein, "hsa-miR-614 gene" or "hsa-miR-61 The term "miR-614" refers to the hsa-miR-614 gene (miRBa 4) set forth in SEQ ID NO: 118. se Accession No. MIMAT0003282) and other species homologs The hsa-miR-614 gene is also included in the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 It can be obtained by the method described in the "hsa- miR-614 has a hairpin-like structure as its precursor, hsa-mir-614 ” (miRBase Accession No. MI0003627, SEQ ID NO: 396 ) is known.

[0198] As used herein, "hsa-miR-7110-5p gene" or "hsa-mi The term "miR-7110-5p" refers to hsa-miR-7110 set forth in SEQ ID NO: 119. -5p gene (miRBase Accession No. MIMAT0028117 ) and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7110-5p has a hairpin-like structure as its precursor, hsa-mir -7110" (miRBase Accession No. MI0022961, sequence Number 397) is known.

[0199] As used herein, "hsa-miR-744-5p gene" or "hsa-miR The term "miR-744-5p" refers to hsa-miR-744-5p as set forth in SEQ ID NO: 120. Gene (miRBase Accession No. MIMAT0004945) and This includes homologs or orthologs of hsa-miR-744-5p from other species. Genes: Berezikov E et al., 2006, Genome Res, vol. 16, p. It can be obtained by the method described in 1289-1298. R-744-5p has a hairpin-like structure as its precursor, hsa-mir-74 4" (miRBase Accession No. MI0005559, SEQ ID NO: 39 8) is known.

[0200] As used herein, "hsa-miR-6769a-5p gene" or "hsa-m The term "hsa-miR-6769a-5p" refers to hsa-miR-6769a-5p as set forth in SEQ ID NO: 121. 69a-5p gene (miRBase Accession No. MIMAT0027 438) and other species homologs or orthologs. The 6769a-5p gene is from Ladewig E et al., 2012, Genome Res It can be obtained by the method described in Vol. 22, pp. 1634-1645. hsa-miR-6769a-5p is a precursor of hs a-mir-6769a” (miRBase Accession No. MI0022 614, SEQ ID NO: 399) is known.

[0201] As used herein, "hsa-miR-4792 gene" or "hsa-miR-4 The term "miR-4792" refers to the hsa-miR-4792 gene (miR-4792) set forth in SEQ ID NO: 122. RBase Accession No. MIMAT0019964) and other species The hsa-miR-4792 gene is a homologue or ortholog of the Per sson H et al., 2011, Cancer Res, Vol. 71, p78-86 Furthermore, "hsa-miR-4792" can be obtained by the method described above. The miRBase Accession No. 100116666444, which has a hairpin-like structure, is a nucleotide sequence of "hsa-mir-4792" (miRBase Accession No. 1001166664444). The sequence number of the nucleotide sequence ...

[0202] As used herein, "hsa-miR-5787 gene" or "hsa-miR-5 The term "miR-5787" refers to the hsa-miR-5787 gene (miR-5787) set forth in SEQ ID NO: 123. RBase Accession No. MIMAT0023252) and other species The hsa-miR-5787 gene is a homologue or ortholog of the Yoo H et al., 2011, Biochem Biophys Res Commun, 415 It can be obtained by the method described in Vol. 1, pp. 567-572. iR-5787 has a hairpin-like structure as its precursor, hsa-mir-578 7" (miRBase Accession No. MI0019797, SEQ ID NO: 40 1) is known.

[0203] As used herein, "hsa-miR-6798-5p gene" or "hsa-mi The term "miR-6798-5p" refers to hsa-miR-6798 as set forth in SEQ ID NO: 124. -5p gene (miRBase Accession No. MIMAT0027496 ) and other species homologs or orthologs. The 8-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6798-5p has a hairpin-like structure as its precursor, hsa-mir -6798" (miRBase Accession No. MI0022643, sequence Number 402) is known.

[0204] As used herein, "hsa-miR-6781-5p gene" or "hsa-mi The term "miR-6781-5p" refers to hsa-miR-6781 set forth in SEQ ID NO: 125. -5p gene (miRBase Accession No. MIMAT0027462 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6781-5p has a hairpin-like structure as its precursor, hsa-mir -6781" (miRBase Accession No. MI0022626, sequence Number 403) is known.

[0205] As used herein, "hsa-miR-4419b gene" or "hsa-miR- The term "miR-4419b" refers to the hsa-miR-4419b gene set forth in SEQ ID NO: 126. (miRBase Accession No. MIMAT0019034) and other The hsa-miR-4419b gene includes species homologs or orthologs. , Jima DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4419b can be obtained by the method described above. The miRBase A receptor has a hairpin-like structure as a precursor of hsa-mir-4419b. Accession No. MI0016861, SEQ ID NO: 404) is known.

[0206] As used herein, "hsa-miR-4446-3p gene" or "hsa-mi The term "miR-4446-3p" refers to hsa-miR-4446 as set forth in SEQ ID NO: 127. -3p gene (miRBase Accession No. MIMAT0018965 ) and other species homologs or orthologs. The 6-3p gene is described in Jima DD et al., 2010, Blood, Vol. 116, e118- The miR-444 gene can be obtained by the method described in e127. 6-3p" has a hairpin-like structure as its precursor "hsa-mir-4446" ( miRBase Accession No. MI0016789, SEQ ID NO: 405) It is known.

[0207] As used herein, "hsa-miR-4259 gene" or "hsa-miR-4 The term "miR-4259" refers to the hsa-miR-4259 gene (miR-4259) set forth in SEQ ID NO: 128. RBase Accession No. MIMAT0016880) and other species The hsa-miR-4259 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4259" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664 (hsa-mir-4259) has a miR-like structure. No. MI0015858, SEQ ID NO: 406) is known.

[0208] As used herein, "hsa-miR-5572 gene" or "hsa-miR-5 The term "miR-5572" refers to the hsa-miR-5572 gene (miR-5572) set forth in SEQ ID NO: 129. RBase Accession No. MIMAT0022260) and other species The hsa-miR-5572 gene is a homologue or ortholog. Don M et al., 2012, Oral Dis, Vol. 18, p. 127-131 hsa-miR-5572 can be obtained by the method described above. The miRBase Accession No. 1000012666644444444 forms a hairpin-like structure. sion No. MI0019117, SEQ ID NO: 407) is known.

[0209] As used herein, "hsa-miR-6075 gene" or "hsa-miR-6 The term "miR-6075" refers to the hsa-miR-6075 gene (miR-6075) set forth in SEQ ID NO: 130. RBase Accession No. MIMAT0023700) and other species The hsa-miR-6075 gene is a homologue or ortholog of the Voe The method described in Illenkle C et al., 2012, RNA, Vol. 18, p. 472-484 hsa-miR-6075 can be obtained by the method described above. The miRBase Accession No. 100002666666 (hsa-mir-6075) (miRBase Accession No. 1000026 ...) forms a hairpin-like structure. ion No. MI0020352, SEQ ID NO: 408) is known.

[0210] As used herein, "hsa-miR-296-3p gene" or "hsa-miR The term "miR-296-3p" refers to hsa-miR-296-3p as set forth in SEQ ID NO: 131. Gene (miRBase Accession No. MIMAT0004679) and This includes homologs or orthologs of other species. Genes: Houbaviy HB et al., 2003, Dev Cell, vol. 5, p. 351 The miR-296 can be obtained by the method described in Ref. 358. The precursor of α-3p is hsa-mir-296 (mi RBase Accession No. MI0000747, sequence number 409) It is being done.

[0211] As used herein, "hsa-miR-6891-5p gene" or "hsa-mi The term "miR-6891-5p" refers to hsa-miR-6891 set forth in SEQ ID NO: 132. -5p gene (miRBase Accession No. MIMAT0027682 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6891-5p has a hairpin-like structure as its precursor, hsa-mir -6891" (miRBase Accession No. MI0022738, sequence Number 410) is known.

[0212] As used herein, "hsa-miR-4745-5p gene" or "hsa-mi The term "miR-4745-5p" refers to hsa-miR-4745 as set forth in SEQ ID NO: 133. -5p gene (miRBase Accession No. MIMAT0019878 ) and other species homologs or orthologs. The 5-5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4745-5p is a precursor of hsa-mir-474, which has a hairpin-like structure. 5" (miRBase Accession No. MI0017384, SEQ ID NO: 41 1) is known.

[0213] As used herein, "hsa-miR-6775-5p gene" or "hsa-mi The term "miR-6775-5p" refers to hsa-miR-6775 as set forth in SEQ ID NO: 134. -5p gene (miRBase Accession No. MIMAT0027450 ) and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6775-5p has a hairpin-like structure as its precursor, hsa-mir -6775" (miRBase Accession No. MI0022620, sequence Number 412) is known.

[0214] As used herein, "hsa-miR-6870-5p gene" or "hsa-mi The term "miR-6870-5p" refers to hsa-miR-6870 set forth in SEQ ID NO: 135. -5p gene (miRBase Accession No. MIMAT0027640 ) and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6870-5p has a hairpin-like structure as its precursor, hsa-mir -6870" (miRBase Accession No. MI0022717, sequence Number 413) is known.

[0215] As used herein, "hsa-miR-920 gene" or "hsa-miR-92 The term "miR-920" refers to the hsa-miR-920 gene (miRBa se Accession No. MIMAT0004970) and other species homologs The hsa-miR-920 gene is a member of the Novotny GW et al., 2007, Int J Androl, vol. 30, pp. 316-326 hsa-miR-920 can be obtained by the method described above. The miRBase Accession No. 10002266664444444 has a hairpin-like structure as a target protein. sion No. MI0005712, SEQ ID NO: 414) is known.

[0216] As used herein, "hsa-miR-4530 gene" or "hsa-miR-4 The term "miR-4530" refers to the hsa-miR-4530 gene (mi RBase Accession No. MIMAT0019069) and other species The hsa-miR-4530 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 In addition, "hsa-miR-4530" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4530" (miRBase Accession No. on No. MI0016897, SEQ ID NO: 415) is known.

[0217] As used herein, "hsa-miR-6819-5p gene" or "hsa-mi The term "miR-6819-5p" refers to hsa-miR-6819 set forth in SEQ ID NO: 138. -5p gene (miRBase Accession No. MIMAT0027538 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6819-5p has a hairpin-like structure as its precursor, hsa-mir -6819" (miRBase Accession No. MI0022664, sequence Number 416) is known.

[0218] As used herein, "hsa-miR-6825-5p gene" or "hsa-mi The term "miR-6825-5p" refers to hsa-miR-6825 set forth in SEQ ID NO: 139. -5p gene (miRBase Accession No. MIMAT0027550 ) and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6825-5p has a hairpin-like structure as its precursor, hsa-mir -6825" (miRBase Accession No. MI0022670, sequence Number 417) is known.

[0219] As used herein, "hsa-miR-7847-3p gene" or "hsa-mi The term "miR-7847-3p" refers to hsa-miR-7847 as set forth in SEQ ID NO: 140. -3p gene (miRBase Accession No. MIMAT0030422 ) and other species homologs or orthologs. The 7-3p gene is Ple H et al., 2012, PLoS One, Vol. 7, e50746 The miR-7847-3p gene can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-7847" (miRB The enzyme (Accession No. MI0025517, SEQ ID NO: 418) is known There are.

[0220] As used herein, "hsa-miR-6131 gene" or "hsa-miR-6 The term "miR-6131" refers to the hsa-miR-6131 gene (miR-6131) set forth in SEQ ID NO: 141. RBase Accession No. MIMAT0024615) and other species The hsa-miR-6131 gene is a homologue or ortholog. Nemann M et al., 2012, Genome Biol Evol, vol. 4, p. 552 The miR-613 can be obtained by the method described in ref. 4. 1” has a hairpin-like structure as its precursor, “hsa-mir-6131” (miR Base Accession No. MI0021276, SEQ ID NO: 419) is known are.

[0221] As used herein, "hsa-miR-4433-3p gene" or "hsa-mi The term "miR-4433-3p" refers to hsa-miR-4433 as set forth in SEQ ID NO: 142. -3p gene (miRBase Accession No. MIMAT0018949 ) and other species homologs or orthologs. The 3-3p gene is described in Jima DD et al., 2010, Blood, Vol. 116, e118- The miR-443 gene can be obtained by the method described in e127. 3-3p" has a hairpin-like structure as its precursor "hsa-mir-4433" ( miRBase Accession No. MI0016773, SEQ ID NO: 420) It is known.

[0222] As used herein, "hsa-miR-1228-5p gene" or "hsa-mi The term "miR-1228-5p" refers to hsa-miR-1228 as set forth in SEQ ID NO: 143. -5p gene (miRBase Accession No. MIMAT0005582 ) and other species homologs or orthologs. The 8-5p gene is described in Berezikov E et al., 2007, Mol Cell, vol. 28 It can be obtained by the method described in the "Hsa-mi R-1228-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 228" (miRBase Accession No. MI0006318, SEQ ID NO: 421) is known.

[0223] As used herein, "hsa-miR-6743-5p gene" or "hsa-mi The term "miR-6743-5p" refers to hsa-miR-6743 as set forth in SEQ ID NO: 144. -5p gene (miRBase Accession No. MIMAT0027387 ) and other species homologs or orthologs. The 3-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6743-5p has a hairpin-like structure as its precursor, hsa-mir -6743" (miRBase Accession No. MI0022588, sequence Number 422) is known.

[0224] As used herein, "hsa-miR-1268a gene" or "hsa-miR- The term "miR-1268a" refers to the hsa-miR-1268a gene set forth in SEQ ID NO: 145. (miRBase Accession No. MIMAT0005922) and other The hsa-miR-1268a gene includes species homologs or orthologs. , Morin RD et al., 2008, Genome Res, Vol. 18, p610-621 Furthermore, "hsa-miR-1268a" can be obtained by the method described in , and its precursor, "hsa-mir-1268a" (miRBa (Accession No. MI0006405, SEQ ID NO: 423) do.

[0225] As used herein, "hsa-miR-3917 gene" or "hsa-miR-3 The term "miR-3917" refers to the hsa-miR-3917 gene (mi RBase Accession No. MIMAT0018191) and other species The hsa-miR-3917 gene is expressed by Cre Lighton CJ et al., 2010, PLoS One, vol. 5, e9637 hsa-miR-3917 can be obtained by the method described above. The miRBase Accession No. 10000126666444 forms a hairpin-like structure. sion No. MI0016423, SEQ ID NO: 424) is known.

[0226] As used herein, "hsa-miR-6786-5p gene" or "hsa-mi The term "miR-6786-5p" refers to hsa-miR-6786 set forth in SEQ ID NO: 147. -5p gene (miRBase Accession No. MIMAT0027472 ) and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6786-5p has a hairpin-like structure as its precursor, hsa-mir -6786" (miRBase Accession No. MI0022631, sequence Number 425) is known.

[0227] As used herein, "hsa-miR-3154 gene" or "hsa-miR-3 The term "miR-3154" refers to the hsa-miR-3154 gene (miR-3154) set forth in SEQ ID NO: 148. RBase Accession No. MIMAT0015028) and other species The hsa-miR-3154 gene is a homologue or ortholog of the Ezikov E et al., 2006, Genome Res, Vol. 16, p1289-129 8. Also, "hsa-miR-3154" can be obtained by the method described in , and its precursor, "hsa-mir-3154" (miRBas e Accession No. MI0014182, SEQ ID NO: 426) is known .

[0228] As used herein, "hsa-miR-638 gene" or "hsa-miR-63 The term "miR-638" refers to the hsa-miR-638 gene (miRBa se Accession No. MIMAT0003308) and other species homologs The hsa-miR-638 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 It can be obtained by the method described in the "hsa- miR-638 has a hairpin-like structure as its precursor, hsa-mir-638 ” (miRBase Accession No. MI0003653, SEQ ID NO: 427 ) is known.

[0229] As used herein, "hsa-miR-6741-5p gene" or "hsa-mi The term "miR-6741-5p" refers to hsa-miR-6741 set forth in SEQ ID NO: 150. -5p gene (miRBase Accession No. MIMAT0027383 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6741-5p has a hairpin-like structure as its precursor, hsa-mir -6741" (miRBase Accession No. MI0022586, sequence Number 428) is known.

[0230] As used herein, "hsa-miR-6889-5p gene" or "hsa-mi The term "miR-6889-5p" refers to hsa-miR-6889 set forth in SEQ ID NO: 151. -5p gene (miRBase Accession No. MIMAT0027678 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6889-5p has a hairpin-like structure as its precursor, hsa-mir -6889" (miRBase Accession No. MI0022736, sequence Number 429) is known.

[0231] As used herein, "hsa-miR-6840-3p gene" or "hsa-mi The term "miR-6840-3p" refers to hsa-miR-6840 as set forth in SEQ ID NO: 152. -3p gene (miRBase Accession No. MIMAT0027583 ) and other species homologs or orthologs. The 0-3p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6840-3p has a hairpin-like structure as its precursor, hsa-mir -6840" (miRBase Accession No. MI0022686, sequence Number 430) is known.

[0232] As used herein, "hsa-miR-6510-5p gene" or "hsa-mi The term "miR-6510-5p" refers to hsa-miR-6510 as set forth in SEQ ID NO: 153. -5p gene (miRBase Accession No. MIMAT0025476 ) and other species homologs or orthologs. The 0-5p gene is Joyce CE et al., 2011, Hum Mol Genet, 2 0, pp. 4025-4040. a-miR-6510-5p has a hairpin-like structure as its precursor, hsa-m ir-6510” (miRBase Accession No. MI0022222, SEQ ID NO: 431) is known.

[0233] As used herein, "hsa-miR-3188 gene" or "hsa-miR-3 The term "miR-3188" refers to the hsa-miR-3188 gene (miR-3188) set forth in SEQ ID NO: 154. RBase Accession No. MIMAT0015070) and other species The hsa-miR-3188 gene is a homologue or ortholog of Sta rk MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3188" can be obtained by The pin-like structure of "hsa-mir-3188" (miRBase Accession No. No. MI0014232, SEQ ID NO: 432) is known.

[0234] As used herein, "hsa-miR-551b-5p gene" or "hsa-mi The term "miR-551b-5p" refers to hsa-miR-551b as set forth in SEQ ID NO: 155. -5p gene (miRBase Accession No. MIMAT0004794 ) and other species homologs or orthologs. The b-5p gene is described in Cummins JM et al., 2006, Proc Natl Aca d Sci USA, Vol. 103, pp. 3687-3692. In addition, "hsa-miR-551b-5p" is a precursor of hair follicles. The pin-like structure of "hsa-mir-551b" (miRBase Accession No. No. MI0003575, SEQ ID NO: 433) is known.

[0235] As used herein, "hsa-miR-5001-5p gene" or "hsa-mi The term "miR-5001-5p" refers to hsa-miR-5001 set forth in SEQ ID NO: 156. -5p gene (miRBase Accession No. MIMAT0021021 ) and other species homologs or orthologs. 1-5p genes are Hansen TB et al., 2011, RNA Biol, Vol. 8, p. 3 78-383. 001-5p has a hairpin-like structure as its precursor, hsa-mir-5001 ” (miRBase Accession No. MI0017867, SEQ ID NO: 434 ) is known.

[0236] As used herein, "hsa-miR-1268b gene" or "hsa-miR- The term "miR-1268b" refers to the hsa-miR-1268b gene set forth in SEQ ID NO: 157. (miRBase Accession No. MIMAT0018925) and other The hsa-miR-1268b gene includes species homologs or orthologs. , Jima DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-1268b can be obtained by the method described above. The miRBase A receptor has a hairpin-like structure as a carrier. Accession No. MI0016748, SEQ ID NO: 435) is known.

[0237] As used herein, "hsa-miR-7107-5p gene" or "hsa-mi The term "miR-7107-5p" refers to hsa-miR-7107 as set forth in SEQ ID NO: 158. -5p gene (miRBase Accession No. MIMAT0028111 ) and other species homologs or orthologs. The 7-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7107-5p has a hairpin-like structure as its precursor, hsa-mir -7107" (miRBase Accession No. MI0022958, sequence Number 436) is known.

[0238] As used herein, "hsa-miR-6824-5p gene" or "hsa-mi The term "miR-6824-5p" refers to hsa-miR-6824 set forth in SEQ ID NO: 159. -5p gene (miRBase Accession No. MIMAT0027548 ) and other species homologs or orthologs. The 4-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6824-5p has a hairpin-like structure as its precursor, hsa-mir -6824" (miRBase Accession No. MI0022669, sequence Number 437) is known.

[0239] As used herein, "hsa-miR-6732-5p gene" or "hsa-mi The term "miR-6732-5p" refers to hsa-miR-6732 as set forth in SEQ ID NO: 160. -5p gene (miRBase Accession No. MIMAT0027365 ) and other species homologs or orthologs. The 2-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6732-5p has a hairpin-like structure as its precursor, hsa-mir -6732" (miRBase Accession No. MI0022577, sequence Number 438) is known.

[0240] As used herein, "hsa-miR-371a-5p gene" or "hsa-mi The term "miR-371a-5p" refers to hsa-miR-371a set forth in SEQ ID NO: 161. -5p gene (miRBase Accession No. MIMAT0004687 ) and other species homologs or orthologs. The a-5p gene is described in Suh MR et al., 2004, Dev Biol, vol. 270, p. 48 The miR-37 gene can be obtained by the method described in U.S. Pat. No. 6,849,868. 1a-5p" has a hairpin-like structure as its precursor, "hsa-mir-371a" (miRBase Accession No. MI0000779, SEQ ID NO: 439) is known.

[0241] As used herein, "hsa-miR-6794-5p gene" or "hsa-mi The term "miR-6794-5p" refers to hsa-miR-6794 set forth in SEQ ID NO: 162. -5p gene (miRBase Accession No. MIMAT0027488 ) and other species homologs or orthologs. The 4-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6794-5p has a hairpin-like structure as its precursor, hsa-mir -6794" (miRBase Accession No. MI0022639, sequence Number 440) is known.

[0242] As used herein, "hsa-miR-6779-5p gene" or "hsa-mi The term "miR-6779-5p" refers to hsa-miR-6779 set forth in SEQ ID NO: 163. -5p gene (miRBase Accession No. MIMAT0027458 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6779-5p has a hairpin-like structure as its precursor, hsa-mir -6779" (miRBase Accession No. MI0022624, sequence Number 441) is known.

[0243] As used herein, "hsa-miR-4271 gene" or "hsa-miR-4 The term "miR-4271" refers to the hsa-miR-4271 gene (miR-4271) set forth in SEQ ID NO: 164. RBase Accession No. MIMAT0016901) and other species The hsa-miR-4271 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4271" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664 (hsa-mir-4271) has a miR-like structure. No. MI0015879, SEQ ID NO: 442) is known.

[0244] As used herein, "hsa-miR-5195-3p gene" or "hsa-mi The term "miR-5195-3p" refers to hsa-miR-5195 as set forth in SEQ ID NO: 165. -3p gene (miRBase Accession No. MIMAT0021127 ) and other species homologs or orthologs. The 5-3p gene is described in Schotte D et al., 2011, Leukemia, Vol. 25, p. It can be obtained by the method described in 1389-1399. R-5195-3p is a precursor of hsa-mir-5, which has a hairpin-like structure. 195" (miRBase Accession No. MI0018174, SEQ ID NO: 443) is known.

[0245] As used herein, "hsa-miR-6762-5p gene" or "hsa-mi The term "miR-6762-5p" refers to hsa-miR-6762 set forth in SEQ ID NO: 166. -5p gene (miRBase Accession No. MIMAT0027424 ) and other species homologs or orthologs. The 2-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6762-5p has a hairpin-like structure as its precursor, hsa-mir -6762" (miRBase Accession No. MI0022607, sequence Number 444) is known.

[0246] As used herein, "hsa-miR-939-5p gene" or "hsa-miR The term "miR-939-5p" refers to hsa-miR-939-5p as set forth in SEQ ID NO: 167. Gene (miRBase Accession No. MIMAT0004982) and This includes homologs or orthologs of other species. The gene is described in Lui WO et al., 2007, Cancer Res, Vol. 67, p6031- The miR-939 can be obtained by the method described in 6043. -5p" has a hairpin-like structure as its precursor, "hsa-mir-939" (mi RBase Accession No. MI0005761, sequence number 445) It is being done.

[0247] As used herein, the term "hsa-miR-1247-3p gene" or "hsa-mi The term "miR-1247-3p" refers to hsa-miR-1247 as set forth in SEQ ID NO: 168. -3p gene (miRBase Accession No. MIMAT0022721 ) and other species homologs or orthologs. The 7-3p gene is described in Morin RD et al., 2008, Genome Res, Vol. 18, The miR gene can be obtained by the method described on pages 610-621. -1247-3p is a precursor of hsa-mir-12, which has a hairpin-like structure. 47" (miRBase Accession No. MI0006382, SEQ ID NO: 4 46) is known.

[0248] As used herein, "hsa-miR-6777-5p gene" or "hsa-mi The term "miR-6777-5p" refers to hsa-miR-6777 set forth in SEQ ID NO: 169. -5p gene (miRBase Accession No. MIMAT0027454 ) and other species homologs or orthologs. The 7-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6777-5p has a hairpin-like structure as its precursor, hsa-mir -6777" (miRBase Accession No. MI0022622, sequence Number 447) is known.

[0249] As used herein, "hsa-miR-6722-3p gene" or "hsa-mi The term "miR-6722-3p" refers to hsa-miR-6722 as set forth in SEQ ID NO: 170. -3p gene (miRBase Accession No. MIMAT0025854 ) and other species homologs or orthologs. The 2-3p gene is described in Li Y et al., 2012, Gene, Vol. 497, p. 330-335. It can be obtained by the method described in the specification. The precursor of miRBa is “hsa-mir-6722” (miRBa (Accession No. MI0022557, SEQ ID NO: 448) do.

[0250] As used herein, "hsa-miR-3656 gene" or "hsa-miR-3 The term "miR-3656" refers to the hsa-miR-3656 gene (miR-3656) set forth in SEQ ID NO: 171. RBase Accession No. MIMAT0018076) and other species The hsa-miR-3656 gene includes homologs or orthologs. ri E et al., 2010, Nucleic Acids Res, Vol. 38, p6234- The miR-365 gene can be obtained by the method described in 6246. 6” has a hairpin-like structure as its precursor, “hsa-mir-3656” (miR Base Accession No. MI0016056, SEQ ID NO: 449) is known are.

[0251] As used herein, "hsa-miR-4688 gene" or "hsa-miR-4 The term "miR-4688" refers to the hsa-miR-4688 gene (miR-4688) set forth in SEQ ID NO: 172. RBase Accession No. MIMAT0019777) and other species The hsa-miR-4688 gene is a homologue or ortholog of the Per sson H et al., 2011, Cancer Res, Vol. 71, p78-86 Furthermore, "hsa-miR-4688" can be obtained by the method described above. The miRBase Accession No. 100002666666666688 has a hairpin-like structure as a target protein. The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0017321, sequence number 450.

[0252] As used herein, "hsa-miR-3195 gene" or "hsa-miR-3 The term "miR-3195" refers to the hsa-miR-3195 gene (miR-3195) set forth in SEQ ID NO: 173. RBase Accession No. MIMAT0015079) and other species The hsa-miR-3195 gene is a homologue or ortholog of the Sta rk MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3195" can be obtained by The pin-like structure of "hsa-mir-3195" (miRBase Accession No. No. MI0014240, SEQ ID NO: 451) is known.

[0253] As used herein, "hsa-miR-6766-5p gene" or "hsa-mi The term "miR-6766-5p" refers to hsa-miR-6766 set forth in SEQ ID NO: 174. -5p gene (miRBase Accession No. MIMAT0027432 ) and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6766-5p has a hairpin-like structure as its precursor, hsa-mir -6766" (miRBase Accession No. MI0022611, sequence Number 452) is known.

[0254] As used herein, "hsa-miR-4447 gene" or "hsa-miR-4 The term "miR-4447" refers to the hsa-miR-4447 gene (miR-4447) set forth in SEQ ID NO: 175. RBase Accession No. MIMAT0018966) and other species The hsa-miR-4447 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4447" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4447" (miRBase Accession No. on No. MI0016790, SEQ ID NO: 453) is known.

[0255] As used herein, "hsa-miR-4656 gene" or "hsa-miR-4 The term "miR-4656" refers to the hsa-miR-4656 gene (miR-4656) set forth in SEQ ID NO: 176. RBase Accession No. MIMAT0019723) and other species The hsa-miR-4656 gene is a homologue or ortholog. sson H et al., 2011, Cancer Res, Vol. 71, p78-86 Furthermore, "hsa-miR-4656" can be obtained by the method described above. The miRBase Accession No. 10000126662 ... The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0017284, sequence number 454.

[0256] As used herein, "hsa-miR-7108-5p gene" or "hsa-mi The term "miR-7108-5p" refers to hsa-miR-7108 as set forth in SEQ ID NO: 177. -5p gene (miRBase Accession No. MIMAT0028113 ) and other species homologs or orthologs. The 8-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7108-5p has a hairpin-like structure as its precursor, hsa-mir -7108" (miRBase Accession No. MI0022959, sequence Number 455) is known.

[0257] As used herein, "hsa-miR-3191-3p gene" or "hsa-mi The term "miR-3191-3p" refers to hsa-miR-3191 set forth in SEQ ID NO: 178. -3p gene (miRBase Accession No. MIMAT0015075 ) and other species homologs or orthologs. 1-3p genes are described in Stark MS et al., 2010, PLoS One, Vol. 5, e96 The miR-3191 gene can be obtained by the method described in 85. 3p" has a hairpin-like structure as its precursor "hsa-mir-3191" (mi RBase Accession No. MI0014236, sequence number 456) It is being done.

[0258] As used herein, "hsa-miR-1273g-3p gene" or "hsa-m The term "miR-1273g-3p" refers to hsa-miR-12 73g-3p gene (miRBase Accession No. MIMAT0022 742) and other species homologs or orthologs. The 1273g-3p gene is described in Reshmi G et al., 2011, Genomics, 97 It can be obtained by the method described in Vol. 1, pp. 333-340. iR-1273g-3p is a precursor of hsa-mir, which has a hairpin-like structure. -1273g” (miRBase Accession No. MI0018003, Column number 457) is known.

[0259] As used herein, "hsa-miR-4463 gene" or "hsa-miR-4 The term "miR-4463" refers to the hsa-miR-4463 gene (miR-4463) set forth in SEQ ID NO: 180. RBase Accession No. MIMAT0018987) and other species The hsa-miR-4463 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4463" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4463" (miRBase Accession No. on No. MI0016811, SEQ ID NO: 458) is known.

[0260] As used herein, "hsa-miR-2861 gene" or "hsa-miR-2 The term "miR-2861" refers to the hsa-miR-2861 gene (miR-2861) set forth in SEQ ID NO: 181. RBase Accession No. MIMAT0013802) and other species The hsa-miR-2861 gene is a homologue or ortholog. H et al., 2009, J Clin Invest, Vol. 119, p3666-3677 hsa-miR-2861 can be obtained by the method described in the The precursor, "hsa-mir-2861" (miRBase A Accession No. MI0013006, SEQ ID NO: 459) is known.

[0261] As used herein, "hsa-miR-3196 gene" or "hsa-miR-3 The term "miR-3196" refers to the hsa-miR-3196 gene (miR-3196) set forth in SEQ ID NO: 182. RBase Accession No. MIMAT0015080) and other species The hsa-miR-3196 gene is a homologue or ortholog of the Sta rk MS et al., 2010, PLoS One, Vol. 5, e9685 In addition, "hsa-miR-3196" can be obtained by The pin-like structure of "hsa-mir-3196" (miRBase Accession No. No. MI0014241, SEQ ID NO: 460) is known.

[0262] As used herein, "hsa-miR-6877-5p gene" or "hsa-mi The term "miR-6877-5p" refers to hsa-miR-6877 as set forth in SEQ ID NO: 183. -5p gene (miRBase Accession No. MIMAT0027654 ) and other species homologs or orthologs. The 7-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6877-5p has a hairpin-like structure as its precursor, hsa-mir -6877" (miRBase Accession No. MI0022724, sequence Number 461) is known.

[0263] As used herein, "hsa-miR-3679-5p gene" or "hsa-mi The term "miR-3679-5p" refers to hsa-miR-3679 as set forth in SEQ ID NO: 184. -5p gene (miRBase Accession No. MIMAT0018104 ) and other species homologs or orthologs. The 79-5p gene is Creighton CJ et al., 2010, PLoS One, 5 The miR-hsa gene can be obtained by the method described in Vol. 3679-5p is a precursor of hsa-mir-367, which has a hairpin-like structure. 9" (miRBase Accession No. MI0016080, SEQ ID NO: 46 2) is known.

[0264] As used herein, "hsa-miR-4442 gene" or "hsa-miR-4 The term "miR-4442" refers to the hsa-miR-4442 gene (miR-4442) set forth in SEQ ID NO: 185. RBase Accession No. MIMAT0018960) and other species The hsa-miR-4442 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4442" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4442" (miRBase Accession No. on No. MI0016785, SEQ ID NO: 463) is known.

[0265] As used herein, "hsa-miR-6789-5p gene" or "hsa-mi The term "miR-6789-5p" refers to hsa-miR-6789 set forth in SEQ ID NO: 186. -5p gene (miRBase Accession No. MIMAT0027478 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6789-5p has a hairpin-like structure as its precursor, hsa-mir -6789" (miRBase Accession No. MI0022634, sequence Number 464) is known.

[0266] As used herein, "hsa-miR-6782-5p gene" or "hsa-mi The term "miR-6782-5p" refers to hsa-miR-6782 set forth in SEQ ID NO: 187. -5p gene (miRBase Accession No. MIMAT0027464 ) and other species homologs or orthologs. The 2-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6782-5p has a hairpin-like structure as its precursor, hsa-mir -6782" (miRBase Accession No. MI0022627, sequence Number 465) is known.

[0267] As used herein, "hsa-miR-486-3p gene" or "hsa-miR The term "miR-486-3p" refers to hsa-miR-486-3p set forth in SEQ ID NO: 188. Gene (miRBase Accession No. MIMAT0004762) and This includes homologs or orthologs of other species. Genes: Fu H et al., 2005, FEBS Lett, vol. 579, p3849-38 54. Also, "hsa-miR-486-3 p" has a hairpin-like structure as its precursor, "hsa-mir-486, hsa-m ir-486-2” (miRBase Accession No. MI0002470 , MI0023622, SEQ ID NOs: 466, 467) are known.

[0268] As used herein, "hsa-miR-6085 gene" or "hsa-miR-6 The term "miR-6085" refers to the hsa-miR-6085 gene (miR-6085) set forth in SEQ ID NO: 189. RBase Accession No. MIMAT0023710) and other species The hsa-miR-6085 gene is a homologue or ortholog of the Voe The method described in Illenkle C et al., 2012, RNA, Vol. 18, p. 472-484 hsa-miR-6085 can be obtained by the method described above. The miRBase Accession No. 100002666666 (hsa-mir-6085) (miRBase Accession No. 1000026666666) forms a hairpin-like structure. ion No. MI0020362, SEQ ID NO: 468) is known.

[0269] As used herein, "hsa-miR-4746-3p gene" or "hsa-mi The term "miR-4746-3p" refers to hsa-miR-4746 as set forth in SEQ ID NO: 190. -3p gene (miRBase Accession No. MIMAT0019881 ) and other species homologs or orthologs. The 6-3p gene is Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4746-3p is a precursor of hsa-mir-474, which has a hairpin-like structure. 6" (miRBase Accession No. MI0017385, SEQ ID NO: 46 9) is known.

[0270] As used herein, "hsa-miR-619-5p gene" or "hsa-miR The term "miR-619-5p" refers to hsa-miR-619-5p as set forth in SEQ ID NO: 191. Gene (miRBase Accession No. MIMAT0026622) and This includes homologs or orthologs of other species. Genes are listed in Cummins JM et al., 2006, Proc Natl Acad Sc i USA, Vol. 103, pp. 3687-3692 In addition, "hsa-miR-619-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. 0003633, SEQ ID NO: 470) is known.

[0271] As used herein, "hsa-miR-937-5p gene" or "hsa-miR The term "miR-937-5p" refers to hsa-miR-937-5p as set forth in SEQ ID NO: 192. Gene (miRBase Accession No. MIMAT0022938) and This includes homologs or orthologs of other species. The gene is described in Lui WO et al., 2007, Cancer Res, Vol. 67, p6031- The miR-937 can be obtained by the method described in 6043. -5p" has a hairpin-like structure as its precursor, "hsa-mir-937" (mi RBase Accession No. MI0005759, sequence number 471) It is being done.

[0272] As used herein, "hsa-miR-6803-5p gene" or "hsa-mi The term "miR-6803-5p" refers to hsa-miR-6803 as set forth in SEQ ID NO: 193. -5p gene (miRBase Accession No. MIMAT0027506 ) and other species homologs or orthologs. The 3-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6803-5p has a hairpin-like structure as its precursor, hsa-mir -6803" (miRBase Accession No. MI0022648, sequence Number 472) is known.

[0273] As used herein, "hsa-miR-4298 gene" or "hsa-miR-4 The term "miR-4298" refers to the hsa-miR-4298 gene (mi RBase Accession No. MIMAT0016852) and other species The hsa-miR-4298 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4298" can be obtained by using hairpin as its precursor. The miRBase Accession No. 10000126666444 has a phosphodiesterase-like structure, "hsa-mir-4298" (miRBase Accession No. 10000126666444). No. MI0015830, SEQ ID NO: 473) is known.

[0274] As used herein, "hsa-miR-4454 gene" or "hsa-miR-4 The term "miR-4454" refers to the hsa-miR-4454 gene (miR-4454) set forth in SEQ ID NO: 195. RBase Accession No. MIMAT0018976) and other species The hsa-miR-4454 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 In addition, "hsa-miR-4454" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4454" (miRBase Accession No. on No. MI0016800, SEQ ID NO: 474) is known.

[0275] As used herein, "hsa-miR-4459 gene" or "hsa-miR-4 The term "miR-4459" refers to the hsa-miR-4459 gene (miR-4459) set forth in SEQ ID NO: 196. RBase Accession No. MIMAT0018981) and other species The hsa-miR-4459 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4459" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4459" (miRBase Accession No. on No. MI0016805, SEQ ID NO: 475) is known.

[0276] As used herein, "hsa-miR-7150 gene" or "hsa-miR-7 The term "miR-7150" refers to the hsa-miR-7150 gene (miR-7150) set forth in SEQ ID NO: 197. RBase Accession No. MIMAT0028211) and other species The hsa-miR-7150 gene is a homologue or ortholog. As A et al., 2009, Nucleic Acids Res, Vol. 37, p3276- 3287. 0” has a hairpin-like structure as its precursor “hsa-mir-7150” (miR Base Accession No. MI0023610, SEQ ID NO: 476) is known are.

[0277] As used herein, "hsa-miR-6880-5p gene" or "hsa-mi The term "miR-6880-5p" refers to hsa-miR-6880 set forth in SEQ ID NO: 198. -5p gene (miRBase Accession No. MIMAT0027660 ) and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6880-5p has a hairpin-like structure as its precursor, hsa-mir -6880" (miRBase Accession No. MI0022727, sequence Number 477) is known.

[0278] As used herein, "hsa-miR-4449 gene" or "hsa-miR-4 The term "miR-4449" refers to the hsa-miR-4449 gene (miR-4449) set forth in SEQ ID NO: 199. RBase Accession No. MIMAT0018968) and other species The hsa-miR-4449 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4449" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4449" (miRBase Accession No. on No. MI0016792, SEQ ID NO: 478) is known.

[0279] As used herein, "hsa-miR-8063 gene" or "hsa-miR-8 The term "miR-8063" refers to the hsa-miR-8063 gene (miR-8063) set forth in SEQ ID NO: 200. RBase Accession No. MIMAT0030990) and other species The hsa-miR-8063 gene is a homologue or ortholog. g HJ et al., 2013, Shock, Vol. 39, p. 480-487 In addition, "hsa-miR-8063" can be obtained by The pin-like structure of "hsa-mir-8063" (miRBase Accession No. No. MI0025899, SEQ ID NO: 479) is known.

[0280] As used herein, "hsa-miR-4695-5p gene" or "hsa-mi The term "miR-4695-5p" refers to hsa-miR-4695 as set forth in SEQ ID NO: 201. -5p gene (miRBase Accession No. MIMAT0019788 ) and other species homologs or orthologs. The 5-5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4695-5p is a precursor of hsa-mir-469, which has a hairpin-like structure. 5" (miRBase Accession No. MI0017328, SEQ ID NO: 48 0) is known.

[0281] As used herein, "hsa-miR-6132 gene" or "hsa-miR-6 The term "miR-6132" refers to the hsa-miR-6132 gene (miR-6132) set forth in SEQ ID NO: 202. RBase Accession No. MIMAT0024616) and other species The hsa-miR-6132 gene is a homologue or ortholog. Nemann M et al., 2012, Genome Biol Evol, vol. 4, p. 552 The miR-613 can be obtained by the method described in ref. 4. 2” has a hairpin-like structure as its precursor, “hsa-mir-6132” (miR Base Accession No. MI0021277, SEQ ID NO: 481) is known are.

[0282] As used herein, "hsa-miR-6829-5p gene" or "hsa-mi The term "miR-6829-5p" refers to hsa-miR-6829 set forth in SEQ ID NO: 203. -5p gene (miRBase Accession No. MIMAT0027558 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6829-5p has a hairpin-like structure as its precursor, hsa-mir -6829" (miRBase Accession No. MI0022674, sequence Number 482) is known.

[0283] As used herein, "hsa-miR-4486 gene" or "hsa-miR-4 The term "miR-4486" refers to the hsa-miR-4486 gene (miR-4486) set forth in SEQ ID NO: 204. RBase Accession No. MIMAT0019020) and other species The hsa-miR-4486 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 In addition, "hsa-miR-4486" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4486" (miRBase Accession No. on No. MI0016847, SEQ ID NO: 483) is known.

[0284] As used herein, "hsa-miR-6805-3p gene" or "hsa-mi The term "miR-6805-3p" refers to hsa-miR-6805 set forth in SEQ ID NO: 205. -3p gene (miRBase Accession No. MIMAT0027511 ) and other species homologs or orthologs. The 5-3p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6805-3p has a hairpin-like structure as its precursor, hsa-mir -6805" (miRBase Accession No. MI0022650, sequence Number 304) is known.

[0285] As used herein, "hsa-miR-6826-5p gene" or "hsa-mi The term "miR-6826-5p" refers to hsa-miR-6826 set forth in SEQ ID NO: 206. -5p gene (miRBase Accession No. MIMAT0027552 ) and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6826-5p has a hairpin-like structure as its precursor, hsa-mir -6826" (miRBase Accession No. MI0022671, sequence Number 484) is known.

[0286] As used herein, "hsa-miR-4508 gene" or "hsa-miR-4 The term "miR-4508" refers to the hsa-miR-4508 gene (miR-4508) set forth in SEQ ID NO: 207. RBase Accession No. MIMAT0019045) and other species The hsa-miR-4508 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4508" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4508" (miRBase Accession No. on No. MI0016872, SEQ ID NO: 485) is known.

[0287] As used herein, "hsa-miR-1343-5p gene" or "hsa-mi The term "miR-1343-5p" refers to hsa-miR-1343 as set forth in SEQ ID NO: 208. -5p gene (miRBase Accession No. MIMAT0027038 ) and other species homologs or orthologs. The 3-5p gene is Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 1343-5p is a precursor of hsa-mir-134, which has a hairpin-like structure. 3" (miRBase Accession No. MI0017320, SEQ ID NO: 36 1) is known.

[0288] As used herein, "hsa-miR-7114-5p gene" or "hsa-mi The term "miR-7114-5p" refers to hsa-miR-7114 set forth in SEQ ID NO: 209. -5p gene (miRBase Accession No. MIMAT0028125 ) and other species homologs or orthologs. The 4-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7114-5p has a hairpin-like structure as its precursor, hsa-mir -7114" (miRBase Accession No. MI0022965, sequence Number 486) is known.

[0289] As used herein, "hsa-miR-3622a-5p gene" or "hsa-m The term "hsa-miR-3622a-5p" refers to hsa-miR-3622a-5p as set forth in SEQ ID NO: 210. 22a-5p gene (miRBase Accession No. MIMAT0018 003) and other species homologs or orthologs. The 3622a-5p gene is described in Witten D et al., 2010, BMC Biol, Vol. 8 , p58. 2a-5p has a hairpin-like structure as its precursor, hsa-mir-3622a ” (miRBase Accession No. MI0016013, SEQ ID NO: 487 ) is known.

[0290] As used herein, "hsa-miR-6765-5p gene" or "hsa-mi The term "miR-6765-5p" refers to hsa-miR-6765 set forth in SEQ ID NO: 211. -5p gene (miRBase Accession No. MIMAT0027430 ) and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6765-5p has a hairpin-like structure as its precursor, hsa-mir -6765" (miRBase Accession No. MI0022610, sequence Number 488) is known.

[0291] As used herein, "hsa-miR-7845-5p gene" or "hsa-mi The term "miR-7845-5p" refers to hsa-miR-7845 as set forth in SEQ ID NO: 212. -5p gene (miRBase Accession No. MIMAT0030420 ) and other species homologs or orthologs. The 5-5p gene is Ple H et al., 2012, PLoS One, Vol. 7, e50746 The miR-7845-5p gene can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-7845" (miRB The enzyme (Accession No. MI0025515, SEQ ID NO: 489) is known There are.

[0292] As used herein, "hsa-miR-3960 gene" or "hsa-miR-3 The term "miR-3960" refers to the hsa-miR-3960 gene (miR-3960) set forth in SEQ ID NO: 213. RBase Accession No. MIMAT0019337) and other species The hsa-miR-3960 gene is a homologue or ortholog of the R et al., 2011, J Biol Chem, Vol. 286, p12328-12339 hsa-miR-3960 can be obtained by the method described in the The precursor of "hsa-mir-3960" (miRBase A Accession No. MI0016964, SEQ ID NO: 490) is known.

[0293] As used herein, "hsa-miR-6749-5p gene" or "hsa-mi The term "miR-6749-5p" refers to hsa-miR-6749 set forth in SEQ ID NO: 214. -5p gene (miRBase Accession No. MIMAT0027398 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6749-5p has a hairpin-like structure as its precursor, hsa-mir -6749" (miRBase Accession No. MI0022594, sequence Number 491) is known.

[0294] As used herein, "hsa-miR-1260b gene" or "hsa-miR- The term "miR-1260b" refers to the hsa-miR-1260b gene set forth in SEQ ID NO: 215. (miRBase Accession No. MIMAT0015041) and other The hsa-miR-1260b gene includes species homologs or orthologs. , Stark MS et al., 2010, PLoS One, Vol. 5, e9685 Furthermore, "hsa-miR-1260b" can be obtained by the method The miRBase Accelerator has a hairpin-like structure called "hsa-mir-1260b" ( Session No. MI0014197, SEQ ID NO: 492) is known.

[0295] As used herein, "hsa-miR-6799-5p gene" or "hsa-mi The term "miR-6799-5p" refers to hsa-miR-6799 set forth in SEQ ID NO: 216. -5p gene (miRBase Accession No. MIMAT0027498 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6799-5p has a hairpin-like structure as its precursor, hsa-mir -6799" (miRBase Accession No. MI0022644, sequence Number 493) is known.

[0296] As used herein, "hsa-miR-4723-5p gene" or "hsa-mi The term "miR-4723-5p" refers to hsa-miR-4723 set forth in SEQ ID NO: 217. -5p gene (miRBase Accession No. MIMAT0019838 ) and other species homologs or orthologs. The 3-5p gene is Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4723-5p is a precursor of hsa-mir-472, which has a hairpin-like structure. 3" (miRBase Accession No. MI0017359, SEQ ID NO: 49 4) is known.

[0297] As used herein, "hsa-miR-6784-5p gene" or "hsa-mi The term "miR-6784-5p" refers to hsa-miR-6784 set forth in SEQ ID NO: 218. -5p gene (miRBase Accession No. MIMAT0027468 ) and other species homologs or orthologs. The 4-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6784-5p has a hairpin-like structure as its precursor, hsa-mir -6784" (miRBase Accession No. MI0022629, sequence Number 495) is known.

[0298] As used herein, "hsa-miR-5100 gene" or "hsa-miR-5 The term "miR-5100" refers to the hsa-miR-5100 gene (miR-5100) set forth in SEQ ID NO: 219. RBase Accession No. MIMAT0022259) and other species The hsa-miR-5100 gene is a homologue or ortholog. Don M et al., 2012, Oral Dis, Vol. 18, p. 127-131 hsa-miR-5100 can be obtained by the method described above. The miRBase Accession No. 10002266664, which forms a hairpin-like structure, is sion No. MI0019116, SEQ ID NO: 496) is known.

[0299] As used herein, "hsa-miR-6769b-5p gene" or "hsa-m The term "miR-6769b-5p" refers to hsa-miR-6769b-5p as set forth in SEQ ID NO: 220. 69b-5p gene (miRBase Accession No. MIMAT0027 620) and other species homologs or orthologs. The 6769b-5p gene is from Ladewig E et al., 2012, Genome Res It can be obtained by the method described in Vol. 22, pp. 1634-1645. hsa-miR-6769b-5p is a precursor of hs a-mir-6769b” (miRBase Accession No. MI0022 706, SEQ ID NO: 497) are known.

[0300] As used herein, "hsa-miR-1207-5p gene" or "hsa-mi The term "miR-1207-5p" refers to hsa-miR-1207 as set forth in SEQ ID NO: 221. -5p gene (miRBase Accession No. MIMAT0005871 ) and other species homologs or orthologs. The 7-5p gene is described in Huppi K et al., 2008, Mol Cancer Res, 6 It can be obtained by the method described in Vol. 1, pp. 212-221. iR-1207-5p is a precursor of the hairpin-like structure known as hsa-mir- 1207" (miRBase Accession No. MI0006340, sequence no. No. 498) is known.

[0301] As used herein, "hsa-miR-642a-3p gene" or "hsa-mi The term "miR-642a-3p" refers to hsa-miR-642a set forth in SEQ ID NO: 222. -3p gene (miRBase Accession No. MIMAT0020924 ) and other species homologs or orthologs. The a-3p gene is described in Cummins JM et al., 2006, Proc Natl Aca d Sci USA, Vol. 103, pp. 3687-3692. In addition, "hsa-miR-642a-3p" is a precursor of hair follicles. The pin-like structure of "hsa-mir-642a" (miRBase Accession No. No. MI0003657, SEQ ID NO: 499) are known.

[0302] As used herein, "hsa-miR-4505 gene" or "hsa-miR-4 The term "miR-4505" refers to the hsa-miR-4505 gene (miR-4505) set forth in SEQ ID NO: 223. RBase Accession No. MIMAT0019041) and other species The hsa-miR-4505 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4505" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4505" (miRBase Accession No. on No. MI0016868, SEQ ID NO: 500) is known.

[0303] As used herein, "hsa-miR-4270 gene" or "hsa-miR-4 The term "miR-4270" refers to the hsa-miR-4270 gene (miR-4270) set forth in SEQ ID NO: 224. RBase Accession No. MIMAT0016900) and other species The hsa-miR-4270 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4270" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664 (hsa-mir-4270) has a phosphodiesterase-like structure. No. MI0015878, SEQ ID NO: 501) is known.

[0304] As used herein, "hsa-miR-6721-5p gene" or "hsa-mi The term "miR-6721-5p" refers to hsa-miR-6721 set forth in SEQ ID NO: 225. -5p gene (miRBase Accession No. MIMAT0025852 ) and other species homologs or orthologs. The 1-5p gene is described in Li Y et al., 2012, Gene, Vol. 497, p. 330-335. The "hsa-miR-6721-5p" can be obtained by the method described in the literature. The precursor of miRBa is a hairpin-like structure called "hsa-mir-6721" (miRBa (Accession No. MI0022556, SEQ ID NO: 502) do.

[0305] As used herein, "hsa-miR-7111-5p gene" or "hsa-mi The term "miR-7111-5p" refers to hsa-miR-7111 set forth in SEQ ID NO: 226. -5p gene (miRBase Accession No. MIMAT0028119 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7111-5p has a hairpin-like structure as its precursor, hsa-mir -7111" (miRBase Accession No. MI0022962, sequence Number 503) is known.

[0306] As used herein, "hsa-miR-6791-5p gene" or "hsa-mi The term "miR-6791-5p" refers to hsa-miR-6791 set forth in SEQ ID NO: 227. -5p gene (miRBase Accession No. MIMAT0027482 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6791-5p has a hairpin-like structure as its precursor, hsa-mir -6791" (miRBase Accession No. MI0022636, sequence Number 504) is known.

[0307] As used herein, "hsa-miR-7109-5p gene" or "hsa-mi The term "miR-7109-5p" refers to hsa-miR-7109 set forth in SEQ ID NO: 228. -5p gene (miRBase Accession No. MIMAT0028115 ) and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7109-5p has a hairpin-like structure as its precursor, hsa-mir -7109" (miRBase Accession No. MI0022960, sequence Number 505) is known.

[0308] As used herein, "hsa-miR-4258 gene" or "hsa-miR-4 The term "miR-4258" refers to the hsa-miR-4258 gene (miR-4258) set forth in SEQ ID NO: 229. RBase Accession No. MIMAT0016879) and other species The hsa-miR-4258 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4258" can be obtained by using hairpin as its precursor. The miRBase Accession No. 1000012666644444 has a phosphodiesterase-like structure, "hsa-mir-4258" (miRBase Accession No. 100001266666444444). No. MI0015857, SEQ ID NO: 506) is known.

[0309] As used herein, "hsa-miR-6515-3p gene" or "hsa-mi The term "miR-6515-3p" refers to hsa-miR-6515 as set forth in SEQ ID NO: 230. -3p gene (miRBase Accession No. MIMAT0025487 ) and other species homologs or orthologs. The 5-3p gene is Joyce CE et al., 2011, Hum Mol Genet, 2 0, pp. 4025-4040. a-miR-6515-3p has a hairpin-like structure as its precursor, hsa-m ir-6515” (miRBase Accession No. MI0022227, SEQ ID NO: 507) is known.

[0310] As used herein, "hsa-miR-6851-5p gene" or "hsa-mi The term "miR-6851-5p" refers to hsa-miR-6851 set forth in SEQ ID NO: 231. -5p gene (miRBase Accession No. MIMAT0027602 ) and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6851-5p has a hairpin-like structure as its precursor, hsa-mir -6851" (miRBase Accession No. MI0022697, sequence Number 508) is known.

[0311] As used herein, "hsa-miR-6125 gene" or "hsa-miR-6 The term "miR-6125" refers to the hsa-miR-6125 gene (miR-6125) set forth in SEQ ID NO: 232. RBase Accession No. MIMAT0024598) and other species The hsa-miR-6125 gene is a homologue or ortholog of the Smi th JL et al., 2012, J Virol, Vol. 86, p5278-5287 Furthermore, "hsa-miR-6125" can be obtained by the method described above. The miRBase Accession No. 10000125 (hsa-mir-6125) has a hairpin-like structure as a The sequence number of the nucleotide sequence ...

[0312] As used herein, "hsa-miR-4749-5p gene" or "hsa-mi The term "miR-4749-5p" refers to hsa-miR-4749 set forth in SEQ ID NO: 233. -5p gene (miRBase Accession No. MIMAT0019885 ) and other species homologs or orthologs. The 9-5p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4749-5p is a precursor of hsa-mir-474, which has a hairpin-like structure. 9" (miRBase Accession No. MI0017388, SEQ ID NO: 51 0) is known.

[0313] As used herein, "hsa-miR-4726-5p gene" or "hsa-mi The term "miR-4726-5p" refers to hsa-miR-4726 set forth in SEQ ID NO: 234. -5p gene (miRBase Accession No. MIMAT0019845 ) and other species homologs or orthologs. The 6-5p gene is Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4726-5p is a precursor of hsa-mir-472, which has a hairpin-like structure. 6" (miRBase Accession No. MI0017363, SEQ ID NO: 51 1) is known.

[0314] As used herein, "hsa-miR-4513 gene" or "hsa-miR-4 The term "miR-4513" refers to the hsa-miR-4513 gene (miR-4513) set forth in SEQ ID NO: 235. RBase Accession No. MIMAT0019050) and other species The hsa-miR-4513 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 In addition, "hsa-miR-4513" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4513" (miRBase Accession No. on No. MI0016879, SEQ ID NO: 512) is known.

[0315] As used herein, "hsa-miR-760 gene" or "hsa-miR-76 The term "miR-760" refers to the hsa-miR-760 gene (miRBa se Accession No. MIMAT0004957) and other species homologs or orthologues thereof. ov E et al., 2006, Genome Res, vol. 16, pp. 1289-1298 Furthermore, "hsa-miR-760" can be obtained by the method described above. The miRBase Accession No. 1000126 ... The sequence number of the gene encoding the nucleotide sequence of the present invention is 513 (sequence number MI0005567).

[0316] As used herein, "hsa-miR-602 gene" or "hsa-miR-60 The term "miR-602" refers to the hsa-miR-602 gene (miRBa 2) set forth in SEQ ID NO: 237. se Accession No. MIMAT0003270) and other species homologs The hsa-miR-602 gene is also included in the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 It can be obtained by the method described in the "hsa- miR-602 has a hairpin-like structure as its precursor, hsa-mir-602 ” (miRBase Accession No. MI0003615, SEQ ID NO: 514 ) is known.

[0317] As used herein, "hsa-miR-423-5p gene" or "hsa-miR The term "miR-423-5p" refers to hsa-miR-423-5p set forth in SEQ ID NO: 238. Gene (miRBase Accession No. MIMAT0004748) and This includes homologs or orthologs of other species. The gene is from Kasashima K et al., 2004, Biochem Biophys Obtained by the method described in Res Commun, Vol. 322, pp. 403-410 In addition, "hsa-miR-423-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. I0001445, SEQ ID NO: 515) is known.

[0318] As used herein, "hsa-miR-92a-2-5p gene" or "hsa-m The term "miR-92a-2-5p" refers to hsa-miR-92a-2-5p as set forth in SEQ ID NO: 239. a-2-5p gene (miRBase Accession No. MIMAT0004 508) and other species homologs or orthologs. The 92a-2-5p gene is described in Mourelatos Z et al., 2002, Genes D EV, Vol. 16, pp. 720-728. hsa-miR-92a-2-5p is a precursor of hsa-miR-92a-2-5p, which has a hairpin-like structure. a-mir-92a-2” (miRBase Accession No. MI0000 094, SEQ ID NO: 516) is known.

[0319] As used herein, "hsa-miR-16-5p gene" or "hsa-miR- The term "miR-16-5p" refers to the hsa-miR-16-5p gene set forth in SEQ ID NO: 240. (miRBase Accession No. MIMAT0000069) and other The hsa-miR-16-5p gene includes species homologs or orthologs. , Lagos-Quintana M et al., 2001, Science, Vol. 294, p. 8 53-858. 6-5p" has a hairpin-like structure as its precursor, "hsa-mir-16-1, h sa-mir-16-2” (miRBase Accession No. MI0000 070, MI0000115, SEQ ID NOs: 517, 518) are known.

[0320] As used herein, "hsa-miR-451a gene" or "hsa-miR-4 The term "miR-451a" refers to the hsa-miR-451a gene (mi RBase Accession No. MIMAT0001631) and other species The hsa-miR-451a gene contains Alt Uvia Y et al., 2005, Nucleic Acids Res, Vol. 33, p. 269 The miR-4 gene can be obtained by the method described in Japanese Patent Application Publication No. 2007-2706. 51a" has a hairpin-like structure as its precursor, "hsa-mir-451a" (m iRBase Accession No. MI0001729, sequence number 519) It is being done.

[0321] As used herein, "hsa-miR-135a-3p gene" or "hsa-mi The term "miR-135a-3p" refers to hsa-miR-135a set forth in SEQ ID NO: 242. -3p gene (miRBase Accession No. MIMAT0004595 ) and other species homologs or orthologs. The a-3p gene is described in Lagos-Quintana M et al., 2002, Curr Biology It can be obtained by the method described in Vol. 12, pp. 735-739. hsa-miR-135a-3p is a precursor of hsa -mir-135a” (miRBase Accession No. MI000045 2, SEQ ID NO: 520) is known.

[0322] As used herein, "hsa-miR-486-5p gene" or "hsa-miR The term "miR-486-5p" refers to hsa-miR-486-5p set forth in SEQ ID NO: 243. Gene (miRBase Accession No. MIMAT0002177) and This includes homologs or orthologs of other species. Genes: Fu H et al., 2005, FEBS Lett, vol. 579, p3849-38 54. Also, "hsa-miR-486-5 p" has a hairpin-like structure as its precursor, "hsa-mir-486, hsa-m ir-486-2” (miRBase Accession No. MI0002470 , MI0023622, SEQ ID NOs: 466, 467) are known.

[0323] As used herein, "hsa-miR-4257 gene" or "hsa-miR-4 The term "miR-4257" refers to the hsa-miR-4257 gene (miR-4257) set forth in SEQ ID NO: 244. RBase Accession No. MIMAT0016878) and other species The hsa-miR-4257 gene is a homologue or ortholog of Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4257" can be obtained by using hairpin as its precursor. The miRBase Accession No. 10000126634444 has a phosphodiesterase-like structure, "hsa-mir-4257" (miRBase Accession No. 100001266344444). No. MI0015856, SEQ ID NO: 521) is known.

[0324] As used herein, "hsa-miR-92b-5p gene" or "hsa-miR The term "miR-92b-5p" refers to hsa-miR-92b-5p set forth in SEQ ID NO: 245. Gene (miRBase Accession No. MIMAT0004792) and This includes homologs or orthologs of hsa-miR-92b-5p from other species. Genes are listed in Cummins JM et al., 2006, Proc Natl Acad Sc i USA, Vol. 103, pp. 3687-3692 In addition, "hsa-miR-92b-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. 0003560, SEQ ID NO: 522) is known.

[0325] As used herein, "hsa-miR-1915-3p gene" or "hsa-mi The term "miR-1915-3p" refers to hsa-miR-1915 as set forth in SEQ ID NO: 246. -3p gene (miRBase Accession No. MIMAT0007892 ) and other species homologs or orthologs. The 5-3p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 24 The "hsa-miR- 1915-3p is a precursor of hsa-mir-191, which has a hairpin-like structure. 5" (miRBase Accession No. MI0008336, SEQ ID NO: 33 9) is known.

[0326] As used herein, "hsa-miR-718 gene" or "hsa-miR-71 The term "miR-718" refers to the hsa-miR-718 gene (miRBa se Accession No. MIMAT0012735) and other species homologs or orthologues thereof. The hsa-miR-718 gene is (2008), BMC Bioinformatics, Vol. 9, p. 39 hsa-miR-718 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-718" (miRBase Accession No. n No. MI0012489, sequence number 523) is known.

[0327] As used herein, "hsa-miR-940 gene" or "hsa-miR-94 The term "miR-940" refers to the hsa-miR-940 gene (miRBa se Accession No. MIMAT0004983) and other species homologs The hsa-miR-940 gene is described in Lui WO et al. , 2007, Cancer Res, Vol. 67, pp. 6031-6043 hsa-miR-940 can be obtained by The apin-like structure of "hsa-mir-940" (miRBase Accession No. No. MI0005762, SEQ ID NO: 524) is known.

[0328] As used herein, "hsa-miR-296-5p gene" or "hsa-miR The term "miR-296-5p" refers to hsa-miR-296-5p set forth in SEQ ID NO: 249. Gene (miRBase Accession No. MIMAT0000690) and This includes homologs or orthologs of other species. Genes: Houbaviy HB et al., 2003, Dev Cell, vol. 5, p. 351 The miR-296 can be obtained by the method described in Ref. 358. -5p has a hairpin-like structure as its precursor, hsa-mir-296 (mi RBase Accession No. MI0000747, sequence number 409) It is being done.

[0329] As used herein, "hsa-miR-23b-3p gene" or "hsa-miR The term "miR-23b-3p" refers to hsa-miR-23b-3p as set forth in SEQ ID NO: 250. Gene (miRBase Accession No. MIMAT0000418) and This includes homologs or orthologs of hsa-miR-23b-3p from other species. The gene is from Lagos-Quintana M et al., 2002, Curr Biol, 1 It can be obtained by the method described in Vol. 2, pp. 735-739. miR-23b-3p has a hairpin-like structure as its precursor, hsa-mir- 23b" (miRBase Accession No. MI0000439, SEQ ID NO: 525) is known.

[0330] As used herein, "hsa-miR-92a-3p gene" or "hsa-miR The term "miR-92a-3p" refers to hsa-miR-92a-3p set forth in SEQ ID NO: 251. Gene (miRBase Accession No. MIMAT0000092) and This includes homologs or orthologs of hsa-miR-92a-3p from other species. Genes: Mourelatos Z et al., 2002, Genes Dev, vol. 16, p. The "hsa-miR- The precursor of 92a-3p is a hairpin-like structure called hsa-mir-92a- 1, hsa-mir-92a-2” (miRBase Accession No. MI 0000093, MI0000094, SEQ ID NOs: 526, 527) are known.

[0331] As used herein, "hsa-miR-658 gene" or "hsa-miR-65 The term "miR-658" refers to the hsa-miR-658 gene (miRBa se Accession No. MIMAT0003336) and other species homologs The hsa-miR-658 gene is also included in the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 It can be obtained by the method described in the "hsa- miR-658 has a hairpin-like structure as its precursor, hsa-mir-658 ” (miRBase Accession No. MI0003682, SEQ ID NO: 528 ) is known.

[0332] As used herein, "hsa-miR-6842-5p gene" or "hsa-mi The term "miR-6842-5p" refers to hsa-miR-6842 as set forth in SEQ ID NO: 253. -5p gene (miRBase Accession No. MIMAT0027586 ) and other species homologs or orthologs. The 2-5p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6842-5p has a hairpin-like structure as its precursor, hsa-mir -6842" (miRBase Accession No. MI0022688, sequence Number 529) is known.

[0333] As used herein, "hsa-miR-6124 gene" or "hsa-miR-6 The term "miR-6124" refers to the hsa-miR-6124 gene (miR-6124) set forth in SEQ ID NO: 254. RBase Accession No. MIMAT0024597) and other species The hsa-miR-6124 gene is a homologue or ortholog of the Smi th JL et al., 2012, J Virol, Vol. 86, p5278-5287 Furthermore, "hsa-miR-6124" can be obtained by the method described above. The miRBase Accession No. 10000124 (hsa-mir-6124) has a hairpin-like structure as a The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0021258, sequence number 530.

[0334] As used herein, "hsa-miR-6765-3p gene" or "hsa-mi The term "miR-6765-3p" refers to hsa-miR-6765 set forth in SEQ ID NO: 255. -3p gene (miRBase Accession No. MIMAT0027431 ) and other species homologs or orthologs. The 5-3p gene is Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6765-3p has a hairpin-like structure as its precursor, hsa-mir -6765" (miRBase Accession No. MI0022610, sequence Number 531) is known.

[0335] As used herein, "hsa-miR-7106-5p gene" or "hsa-mi The term "miR-7106-5p" refers to hsa-miR-7106 set forth in SEQ ID NO: 256. -5p gene (miRBase Accession No. MIMAT0028109 ) and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-7106-5p has a hairpin-like structure as its precursor, hsa-mir -7106" (miRBase Accession No. MI0022957, sequence Number 532) is known.

[0336] As used herein, "hsa-miR-4534 gene" or "hsa-miR-4 The term "miR-4534" refers to the hsa-miR-4534 gene (miR-4534) set forth in SEQ ID NO: 257. RBase Accession No. MIMAT0019073) and other species The hsa-miR-4534 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4534" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4534" (miRBase Accession No. on No. MI0016901, SEQ ID NO: 533) is known.

[0337] As used herein, "hsa-miR-92b-3p gene" or "hsa-miR The term "miR-92b-3p" refers to hsa-miR-92b-3p set forth in SEQ ID NO: 258. Gene (miRBase Accession No. MIMAT0003218) and This includes homologs or orthologs of hsa-miR-92b-3p from other species. Genes are listed in Cummins JM et al., 2006, Proc Natl Acad Sc i USA, Vol. 103, pp. 3687-3692 In addition, "hsa-miR-92b-3p" has a hairpin-like structure as its precursor. The miRBase Accession No. 0003560, SEQ ID NO: 522) is known.

[0338] As used herein, "hsa-miR-3135b gene" or "hsa-miR- The term "miR-3135b" refers to the hsa-miR-3135b gene set forth in SEQ ID NO: 259. (miRBase Accession No. MIMAT0018985) and other The hsa-miR-3135b gene includes species homologs or orthologs. , Jima DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-3135b can be obtained by the method described above. The miRBase A receptor has a hairpin-like structure as a precursor of hsa-mir-3135b. Accession No. MI0016809, SEQ ID NO: 534) is known.

[0339] As used herein, "hsa-miR-4687-3p gene" or "hsa-mi The term "miR-4687-3p" refers to hsa-miR-4687 set forth in SEQ ID NO: 260. -3p gene (miRBase Accession No. MIMAT0019775 ) and other species homologs or orthologs. The 7-3p gene is described in Persson H et al., 2011, Cancer Res, Vol. 71 The "hsa-miR- 4687-3p is a precursor of hsa-mir-468, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017319, SEQ ID NO: 53 5) is known.

[0340] As used herein, "hsa-miR-762 gene" or "hsa-miR-76 The term "miR-762" refers to the hsa-miR-762 gene (miRBa se Accession No. MIMAT0010313) and other species homologs or orthologues thereof. ov E et al., 2006, Genome Res, vol. 16, pp. 1289-1298 Furthermore, "hsa-miR-762" can be obtained by the method described above. The miRBase Accession No. 126621 (hsa-mir-762) has a hairpin-like structure as a target. The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0003892, sequence number 536.

[0341] As used herein, "hsa-miR-3619-3p gene" or "hsa-mi The term "miR-3619-3p" refers to hsa-miR-3619 set forth in SEQ ID NO: 262. -3p gene (miRBase Accession No. MIMAT0019219 ) and other species homologs or orthologs. The 9-3p gene is described in Witten D et al., 2010, BMC Biol, Vol. 8, p. 58 The miR-3619-3p gene can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-3619" (miRB The enzyme (Accession No. MI0016009, SEQ ID NO: 537) is known There are.

[0342] As used herein, "hsa-miR-4467 gene" or "hsa-miR-4 The term "miR-4467" refers to the hsa-miR-4467 gene (miR-4467) set forth in SEQ ID NO: 263. RBase Accession No. MIMAT0018994) and other species The hsa-miR-4467 gene is a homologue or ortholog of the Jim a Method described in DD et al., 2010, Blood, Vol. 116, p. e118-e127 Furthermore, "hsa-miR-4467" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4467" (miRBase Accession No. on No. MI0016818, SEQ ID NO: 538) is known.

[0343] As used herein, "hsa-miR-557 gene" or "hsa-miR-55 The term "miR-557" refers to the hsa-miR-557 gene (miRBa 7) set forth in SEQ ID NO: 264. se Accession No. MIMAT0003221) and other species homologs The hsa-miR-557 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci USA, vol. 103 It can be obtained by the method described in the "hsa- miR-557 has a hairpin-like structure as its precursor, hsa-mir-557 ” (miRBase Accession No. MI0003563, SEQ ID NO: 539 ) is known.

[0344] As used herein, "hsa-miR-1237-5p gene" or "hsa-mi The term "miR-1237-5p" refers to hsa-miR-1237 as set forth in SEQ ID NO: 265. -5p gene (miRBase Accession No. MIMAT0022946 ) and other species homologs or orthologs. The 7-5p gene is described in Berezikov E et al., 2007, Mol Cell, vol. 28 It can be obtained by the method described in the "Hsa-mi R-1237-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 237" (miRBase Accession No. MI0006327, SEQ ID NO: 540) is known.

[0345] As used herein, "hsa-miR-1908-5p gene" or "hsa-mi The term "miR-1908-5p" refers to hsa-miR-1908 as set forth in SEQ ID NO: 266. -5p gene (miRBase Accession No. MIMAT0007881 ) and other species homologs or orthologs. The 8-5p gene is described in Bar M et al., 2008, Stem Cells, Vol. 26, p. 24 The "hsa-miR- 1908-5p is a precursor of hsa-mir-190, which has a hairpin-like structure. 8" (miRBase Accession No. MI0008329, SEQ ID NO: 54 1) is known.

[0346] As used herein, "hsa-miR-4286 gene" or "hsa-miR-4 The term "miR-4286" refers to the hsa-miR-4286 gene (miR-4286) set forth in SEQ ID NO: 267. RBase Accession No. MIMAT0016916) and other species The hsa-miR-4286 gene is a homologue or ortholog of the Gof f By the method described in LA et al., 2009, PLoS One, Vol. 4, e7192 In addition, "hsa-miR-4286" can be obtained by using hairpin as its precursor. The miRBase Accession No. 1000012664444444 has a phosphodiesterase-like structure. No. MI0015894, SEQ ID NO: 542) is known.

[0347] As used herein, "hsa-miR-6885-5p gene" or "hsa-mi The term "miR-6885-5p" refers to hsa-miR-6885 set forth in SEQ ID NO: 268. -5p gene (miRBase Accession No. MIMAT0027670 ) and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res, vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6885-5p has a hairpin-like structure as its precursor, hsa-mir -6885" (miRBase Accession No. MI0022732, sequence Number 543) is known.

[0348] As used herein, "hsa-miR-6763-5p gene" or "hsa-mi The term "miR-6763-5p" refers to hsa-miR-6763 set forth in SEQ ID NO: 269. -5p gene (miRBase Accession No. MIMAT0027426 ) and other species homologs or orthologs. The 3-5p genes are described in Ladewig E et al., 2012, Genome Res, Vol. 22 It can be obtained by the method described in the above, pp. 1634-1645. miR-6763-5p has a hairpin-like structure as its precursor, hsa-mir -6763" (miRBase Accession No. MI0022608, sequence Number 544) is known.

[0349] As used herein, "hsa-miR-6089 gene" or "hsa-miR-6 The term "miR-6089" refers to the hsa-miR-6089 gene (miR-6089) set forth in SEQ ID NO: 851. RBase Accession No. MIMAT0023714) and other species The hsa-miR-6089 gene is a homologue or ortholog of the JK et al., 2012, Stem Cells Dev, Vol. 21, p2049-205 7. Also, "hsa-miR-6089" can be obtained by the method described in , and its precursors, "hsa-mir-6089-1" and "hsa-m ir-6089-2” (miRBase Accession No. MI002036 6, MI0023563, SEQ ID NOs: 857, 858) are known.

[0350] As used herein, "hsa-miR-6816-5p gene" or "hsa-mi The term "miR-6816-5p" refers to hsa-miR-6816 set forth in SEQ ID NO: 852. -5p gene (miRBase Accession No. MIMAT0027532 ) and other species homologs or orthologs. The 16-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 It can be obtained by the method described in Vol. 2, pp. 1634-1645. a-miR-6816-5p has a hairpin-like structure as its precursor, hsa-m ir-6816” (miRBase Accession No. MI0022661, SEQ ID NO: 859) is known.

[0351] As used herein, "hsa-miR-4466 gene" or "hsa-miR-4 The term "miR-4466" refers to the hsa-miR-4466 gene (miR-4466) set forth in SEQ ID NO: 853. RBase Accession No. MIMAT0018993) and other species The hsa-miR-4466 gene is a homologue or ortholog. Ma DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4466 can be obtained by the method described above. The miRBase Accession No. 10000266 (hsa-mir-4466) forms a hairpin-like structure. ion No. MI0016817, SEQ ID NO: 860) is known.

[0352] As used herein, "hsa-miR-4488 gene" or "hsa-miR-4 The term "miR-4488" refers to the hsa-miR-4488 gene (miR-4488) set forth in SEQ ID NO: 854. RBase Accession No. MIMAT0019022) and other species The hsa-miR-4488 gene is a homologue or ortholog of the Ji Ma DD et al., 2010, Blood, Vol. 116, e118-e127 hsa-miR-4488 can be obtained by the method described above. The miRBase Accession No. 10062666666 (hsa-mir-4488) forms a hairpin-like structure. ion No. MI0016849, SEQ ID NO: 861) is known.

[0353] As used herein, "hsa-miR-6752-5p gene" or "hsa-mi The term "miR-6752-5p" refers to hsa-miR-6752 set forth in SEQ ID NO: 855. -5p gene (miRBase Accession No. MIMAT0027404 ) and other species homologs or orthologs. The 52-5p gene is Ladewig E et al., 2012, Genome Res, 22 It can be obtained by the method described in Vol. 1, pp. 1634-1645. -miR-6752-5p has a hairpin-like structure as its precursor, "hsa-mi r-6752" (miRBase Accession No. MI0022597, Column number 862) is known.

[0354] As used herein, "hsa-miR-4739 gene" or "hsa-miR-4 The term "miR-4739" refers to the hsa-miR-4739 gene (miR-4739) set forth in SEQ ID NO: 856. RBase Accession No. MIMAT0019868) and other species The hsa-miR-4739 gene is a homologue or ortholog of the rsson H et al., 2011, Cancer Res, Vol. 71, p78-86 hsa-miR-4739 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure called "hsa-mir-4739" ( Session No. MI0017377, SEQ ID NO: 863) is known.

[0355] In addition, mature miRNAs are formed from RNA precursors with hairpin-like structures. When excised as A, one to several bases before and after the sequence may be excised shorter or longer, Base substitutions can occur, resulting in mutants, called isomiRs (Morin R D. et al., 2008, Genome Res., Vol. 18, pp. 610-621). In RBase Release 20, any of SEQ ID NOs: 1 to 269 and 851 to 856 In addition to the base sequences shown above, there are numerous isomiRs, such as those shown in SEQ ID NOs: 545 to 850. Variants and fragments of the nucleotide sequences represented by any of nucleotides 864 to 871 are also shown. These mutants also contain the bases represented by any of SEQ ID NOs: 1 to 269 and 851 to 856. The miRNAs can be obtained as miRNAs having the sequences of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 8, 11, 14, 15, 19, 20, 21, 23, 27, 28, 31, 35, 37, 38, 40, 42, 43, 47, 48, 50, 51, 52, 55, 56, 5 8, 60, 61, 62, 64, 65, 66, 67, 71, 72, 73, 76, 77, 78 , 79, 80, 82, 83, 85, 86, 88, 89, 90, 92, 95, 97, 98, 99, 100, 102, 103, 107, 109, 110, 113, 114, 115, 1 16, 117, 118, 120, 122, 123, 126, 127, 129, 131, 1 33, 137, 141, 142, 143, 145, 146, 148, 149, 153, 1 54, 155, 156, 157, 161, 164, 165, 167, 168, 171, 1 72, 173, 178, 179, 180, 181, 182, 184, 185, 188, 1 91, 192, 194, 195, 196, 199, 201, 202, 204, 207, 2 10, 213, 215, 217, 219, 222, 223, 225, 230, 232, 2 33, 234, 235, 236, 238, 239, 240, 241, 242, 243, 2 45, 246, 247, 248, 249, 250, 251, 252, 254, 258, 2 59, 260, 263, 265, 266, 267, 851, 853, 854 and 856 or a polynucleotide consisting of a base sequence in which u is t in the base sequence Among the mutants of otide, for example, those registered in miRBase Release 20 The longest variants are SEQ ID NOs: 545, 547, 549, 551, 553, and 5 55, 557, 559, 561, 563, 565, 567, 569, 571, 573, 5 75, 577, 579, 581, 583, 585, 587, 589, 591, 593, 5 95, 597, 599, 601, 603, 605, 607, 609, 611, 613, 6 15, 617, 619, 621, 623, 625, 627, 629, 631, 633, 6 35, 637, 639, 641, 643, 645, 647, 649, 651, 653, 6 55, 657, 659, 661, 663, 665, 667, 669, 671, 673, 6 75, 677, 679, 681, 683, 685, 687, 689, 691, 693, 6 95, 697, 699, 701, 703, 705, 707, 709, 711, 713, 7 15, 717, 719, 721, 723, 725, 727, 729, 731, 733, 7 35, 737, 739, 741, 743, 745, 747, 749, 751, 753, 7 55, 757, 759, 761, 763, 765, 767, 769, 771, 773, 7 75, 777, 779, 781, 783, 785, 787, 789, 791, 793, 7 95, 797, 799, 801, 803, 805, 807, 809, 811, 813, 8 15, 817, 819, 821, 823, 825, 827, 829, 831, 833, 8 35, 837, 839, 841, 843, 845, 847, 849, 864, 866, 8 68 and 870. Also, the polynucleotides of the present invention are represented by SEQ ID NO: 1, 2, 3, 4, 5, 6, 8, 11, 14, 15, 19, 20, 21, 23, 27, 28, 3 1, 35, 37, 38, 40, 42, 43, 47, 48, 50, 51, 52, 55, 56 , 58, 60, 61, 62, 64, 65, 66, 67, 71, 72, 73, 76, 77, 78, 79, 80, 82, 83, 85, 86, 88, 89, 90, 92, 95, 97, 9 8, 99, 100, 102, 103, 107, 109, 110, 113, 114, 115 , 116, 117, 118, 120, 122, 123, 126, 127, 129, 131 , 133, 137, 141, 142, 143, 145, 146, 148, 149, 153 , 154, 155, 156, 157, 161, 164, 165, 167, 168, 171 , 172, 173, 178, 179, 180, 181, 182, 184, 185, 188 , 191, 192, 194, 195, 196, 199, 201, 202, 204, 207 , 210, 213, 215, 217, 219, 222, 223, 225, 230, 232 , 233, 234, 235, 236, 238, 239, 240, 241, 242, 243 , 245, 246, 247, 248, 249, 250, 251, 252, 254, 258 , 259, 260, 263, 265, 266, 267, 851, 853, 854 and 85 6 or a polynucleotide consisting of the base sequence represented by the base sequence in which u is t Nucleotide variants, for example, those registered in miRBase Release 20 The shortest variants are SEQ ID NOs: 546, 548, 550, 552, and 555, respectively. 4, 556, 558, 560, 562, 564, 566, 568, 570, 572, 57 4, 576, 578, 580, 582, 584, 586, 588, 590, 592, 59 4, 596, 598, 600, 602, 604, 606, 608, 610, 612, 61 4, 616, 618, 620, 622, 624, 626, 628, 630, 632, 63 4, 636, 638, 640, 642, 644, 646, 648, 650, 652, 65 4, 656, 658, 660, 662, 664, 666, 668, 670, 672, 67 4, 676, 678, 680, 682, 684, 686, 688, 690, 692, 69 4, 696, 698, 700, 702, 704, 706, 708, 710, 712, 71 4, 716, 718, 720, 722, 724, 726, 728, 730, 732, 73 4, 736, 738, 740, 742, 744, 746, 748, 750, 752, 75 4, 756, 758, 760, 762, 764, 766, 768, 770, 772, 77 4, 776, 778, 780, 782, 784, 786, 788, 790, 792, 79 4, 796, 798, 800, 802, 804, 806, 808, 810, 812, 81 4, 816, 818, 820, 822, 824, 826, 828, 830, 832, 83 4, 836, 838, 840, 842, 844, 846, 848, 850, 865, 86 7, 869 and 871. In addition to the mutants and fragments, the sequences of SEQ ID NOs: 1 to 269 and 851 registered in miRBase are also included. Polynucleotides that are isomiRs include up to 856 polynucleotides. A polynucleotide comprising a base sequence represented by any one of 1 to 269 and 851 to 856 Examples include any of the precursors SEQ ID NOS: 270 to 544 and 857 to 863, respectively. Examples of polynucleotides include those represented by the following:

[0356] Names of genes represented by SEQ ID NOs: 1 to 871 and miRBase Accession Numbers The registration numbers are listed in Table 1.

[0357] As used herein, the term "capable of specifically binding" refers to the nucleic acid probe or probe used in the present invention. This means that the primer binds to a specific target nucleic acid and is substantially incapable of binding to other nucleic acids. .

[0358] [Table 1] TIFF2025128367000002.tif246143TIFF2025128367000003.tif247143TIFF2025128367000004.tif246143TIFF20 25128367000005.tif246143TIFF2025128367000006.tif248144TIFF2025128367000007.tif247144TIFF20251283 67000008.tif247145TIFF2025128367000009.tif246144TIFF2025128367000010.tif248145TIFF20251283670000 11.tif247145TIFF2025128367000012.tif247146TIFF2025128367000013.tif247146TIFF2025128367000014.tif 248145TIFF2025128367000015.tif247146TIFF2025128367000016.tif249143TIFF2025128367000017.tif248145 TIFF2025128367000018.tif248145TIFF2025128367000019.tif248144TIFF2025128367000020.tif248145TIFF20 25128367000021.tif248143TIFF2025128367000022.tif247143TIFF2025128367000023.tif247146TIFF2025128367000024.tif247143TIFF2025128367000025.tif73145This specification is based on Japanese Patent Application Nos. 2014-122672 and 2015-069321, from which the present application claims priority. It includes the contents described in the specification and / or drawings. [Effects of the Invention]

[0359] The present invention makes it possible to detect breast cancer easily and with high accuracy. The indicators are several miRNA measurements in the patient's blood, serum, and / or plasma, which can be collected minimally invasively. This makes it possible to easily detect whether a patient has breast cancer or not. [Brief explanation of the drawings]

[0360] [Figure 1] This figure shows the relationship between the base sequences of hsa-miR-6805-5p, represented by sequence number 34, which is generated from its precursor hsa-mir-6805, represented by sequence number 304, and hsa-miR-6805-3p, represented by sequence number 205. [Figure 2] Left: The vertical axis shows the measured expression levels of hsa-miR-4783-3p (SEQ ID NO: 1) for healthy individuals (100 individuals) and breast cancer patients (62 individuals) selected as the training sample group. The horizontal line in the figure indicates the threshold (6.63) for discriminating between the two groups, optimized by Fisher's discriminant analysis. Right: The vertical axis shows the measured expression levels of hsa-miR-4783-3p (SEQ ID NO: 1) for healthy individuals (50 individuals) and breast cancer patients (31 individuals) selected as the test sample group. The horizontal line in the figure indicates the threshold (6.63) for discriminating between the two groups, set in the training sample group. [Figure 3] Left: The horizontal axis shows the measured expression levels of hsa-miR-4783-3p (SEQ ID NO: 1) and the vertical axis shows the measured expression levels of hsa-miR-4730 (SEQ ID NO: 2) for healthy individuals (100 individuals, circles) and breast cancer patients (62 individuals, triangles) selected as the training sample group. The line in the figure represents the discriminant function (0 = 1.41x + y + 0.77) optimized by Fisher's discriminant analysis to discriminate between the two groups. Right: The horizontal axis shows the measured expression levels of hsa-miR-4783-3p (SEQ ID NO: 1) and the vertical axis shows the measured expression levels of hsa-miR-4730 (SEQ ID NO: 2) for healthy individuals (50 individuals, circles) and breast cancer patients (31 individuals, triangles) selected as the test sample group. The line in the figure represents the threshold (0 = 1.41x + y + 0.77) for discriminating between the two groups, established for the training sample group. [Figure 4]A: A discriminant equation was created using Fisher's discriminant analysis based on the expression level measurements of hsa-miR-602 (SEQ ID NO: 237) and hsa-miR-4730 (SEQ ID NO: 2) from 62 breast cancer patients, 102 healthy subjects, and 33 prostate cancer patients selected as the training sample group (1.87 x hsa-miR-4730 + 0.42 x hsa-miR-602 - 18.58). The discriminant score obtained from the discriminant equation is shown on the vertical axis, with the sample group on the horizontal axis. The dotted line in the figure indicates the discrimination boundary for discriminating between the two groups, where the discriminant score is 0. B: The discriminant scores obtained from the discriminant equation created for the training sample group are shown on the vertical axis, with the sample group on the horizontal axis, for the expression level measurements of hsa-miR-602 (SEQ ID NO: 237) and hsa-miR-4730 (SEQ ID NO: 2) from 31 breast cancer patients, 48 ​​healthy subjects, and 19 prostate cancer patients selected as the test sample group. The dotted line in the figure indicates the discrimination boundary for discriminating between the two groups, where the discrimination score is 0. DETAILED DESCRIPTION OF THE INVENTION

[0361] The present invention will be described in more detail below. 1. Target nucleic acids for breast cancer The above-defined nucleic acid probe or primer for detecting breast cancer of the present invention is used to detect breast cancer or are major breast cancer markers for detecting the presence and / or absence of breast cancer cells. The target nucleic acids include hsa-miR-4783-3p, hsa-miR-4730, and hsa- miR-1307-3p, hsa-miR-4634, hsa-miR-663a, hs a-miR-4532, hsa-miR-7704, hsa-miR-3178, hsa -miR-6729-5p, hsa-miR-6090, hsa-miR-4732-5 p, hsa-miR-3184-5p, hsa-miR-6727-5p, hsa-mi R-6088, hsa-miR-4674, hsa-miR-8073, hsa-miR -4787-5p、hsa-miR-1469、hsa-miR-125a-3p、hs a-miR-1233-5p、hsa-miR-885-3p、hsa-miR-680 2-5p、hsa-miR-328-5p、hsa-miR-6787-5p、hsa- miR-8069, hsa-miR-6875-5p, hsa-miR-1246, hs a-miR-4734、hsa-miR-6757-5p、hsa-miR-6756- 5p、hsa-miR-3665、hsa-miR-6836-3p、hsa-miR- 6821-5p、hsa-miR-6805-5p、hsa-miR-4728-5p、 hsa-miR-6726-5p、hsa-miR-197-5p、hsa-miR-1 49-3p、hsa-miR-6850-5p、hsa-miR-4476、hsa-m iR-6858-5p、hsa-miR-564、hsa-miR-4763-3p、h sa-miR-575、hsa-miR-6771-5p、hsa-miR-1231、 hsa-miR-1908-3p、hsa-miR-150-3p、hsa-miR-3 937、hsa-miR-887-3p、hsa-miR-3940-5p、hsa-m iR-4741、hsa-miR-6808-5p、hsa-miR-6869-5p、 hsa-miR-5090, hsa-miR-615-5p, hsa-miR-8072 、hsa-miR-128-1-5p、hsa-miR-1238-5p、hsa-mi R-365a-5p、hsa-miR-204-3p、hsa-miR-4492、hs a-miR-6785-5p、hsa-miR-6511a-5p、hsa-miR-4 525、hsa-miR-1915-5p、hsa-miR-3180、hsa-miR -6879-5p、hsa-miR-1199-5p、hsa-miR-6746-5p hsa-miR-711, hsa-miR-663b, hsa-miR-4707-3 p、hsa-miR-6893-5p、hsa-miR-4675、hsa-miR-4 638-5p、hsa-miR-4651、hsa-miR-6087、hsa-miR -4665-5p、hsa-miR-4758-5p、hsa-miR-6887-5p hsa-miR-3620-5p, hsa-miR-1909-3p, hsa-miR -7641、hsa-miR-6724-5p、hsa-miR-1343-3p、hs a-miR-6780b-5p、hsa-miR-4484、hsa-miR-4690 -5p、hsa-miR-4429、hsa-miR-1227-5p、hsa-miR -4725-3p、hsa-miR-6861-5p、hsa-miR-6812-5p 、hsa-miR-3197、hsa-miR-8059、hsa-miR-3185、 hsa-miR-4706、hsa-miR-4497、hsa-miR-3131、h sa-miR-6806-5p、hsa-miR-187-5p、hsa-miR-31 80-3p、hsa-miR-6848-5p、hsa-miR-6820-5p、hs a-miR-6800-5p、hsa-miR-6717-5p、hsa-miR-67 95-5p、hsa-miR-4632-5p、hsa-miR-665、hsa-mi R-6778-5p、hsa-miR-3663-3p、hsa-miR-4689、h sa-miR-211-3p、hsa-miR-6511b-5p、hsa-miR-4 750-5p、hsa-miR-6126、hsa-miR-614、hsa-miR- 7110-5p、hsa-miR-744-5p、hsa-miR-6769a-5p、 hsa-miR-4792, hsa-miR-5787, hsa-miR-6798-5 p、hsa-miR-6781-5p、hsa-miR-4419b、hsa-miR- 4446-3p、hsa-miR-4259、hsa-miR-5572、hsa-mi R-6075、hsa-miR-296-3p、hsa-miR-6891-5p、hs a-miR-4745-5p、hsa-miR-6775-5p、hsa-miR-68 70-5p、hsa-miR-920、hsa-miR-4530、hsa-miR-6 819-5p、hsa-miR-6825-5p、hsa-miR-7847-3p、h sa-miR-6131, hsa-miR-4433-3p, hsa-miR-1228 -5p、hsa-miR-6743-5p、hsa-miR-1268a、hsa-mi R-3917、hsa-miR-6786-5p、hsa-miR-3154、hsa- miR-638、hsa-miR-6741-5p、hsa-miR-6889-5p、 hsa-miR-6840-3p、hsa-miR-6510-5p、hsa-miR- 3188、hsa-miR-551b-5p、hsa-miR-5001-5p、hsa -miR-1268b、hsa-miR-7107-5p、hsa-miR-6824- 5p、hsa-miR-6732-5p、hsa-miR-371a-5p、hsa-m iR-6794-5p、hsa-miR-6779-5p、hsa-miR-4271、 hsa-miR-5195-3p、hsa-miR-6762-5p、hsa-miR- 939-5p、hsa-miR-1247-3p、hsa-miR-6777-5p、h sa-miR-6722-3p、hsa-miR-3656、hsa-miR-4688 hsa-miR-3195, hsa-miR-6766-5p, hsa-miR-44 47、hsa-miR-4656、hsa-miR-7108-5p、hsa-miR- 3191-3p、hsa-miR-1273g-3p、hsa-miR-4463、hs a-miR-2861、hsa-miR-3196、hsa-miR-6877-5p、 hsa-miR-3679-5p, hsa-miR-4442, hsa-miR-678 9-5p、hsa-miR-6782-5p、hsa-miR-486-3p、hsa- miR-6085、hsa-miR-4746-3p、hsa-miR-619-5p、 hsa-miR-937-5p、hsa-miR-6803-5p、hsa-miR-4 298, hsa-miR-4454, hsa-miR-4459, hsa-miR-71 50、hsa-miR-6880-5p、hsa-miR-4449、hsa-miR- 8063、hsa-miR-4695-5p、hsa-miR-6132、hsa-mi R-6829-5p、hsa-miR-4486、hsa-miR-6805-3p、h sa-miR-6826-5p、hsa-miR-4508、hsa-miR-1343 -5p、hsa-miR-7114-5p、hsa-miR-3622a-5p、hsa -miR-6765-5p、hsa-miR-7845-5p、hsa-miR-396 0、hsa-miR-6749-5p、hsa-miR-1260b、hsa-miR- 6799-5p, hsa-miR-4723-5p, hsa-miR-6784-5p, hsa-miR-5100, hsa-miR-6769b-5p, hsa-miR-12 07-5p, hsa-miR-642a-3p, hsa-miR-4505, hsa-m iR-4270, hsa-miR-6721-5p, hsa-miR-7111-5p, hsa-miR-6791-5p, hsa-miR-7109-5p, hsa-miR- 4258, hsa-miR-6515-3p, hsa-miR-6851-5p, hsa -miR-6125, hsa-miR-4749-5p, hsa-miR-4726-5 p, hsa-miR-4513, hsa-miR-6089, hsa-miR-6816 -5p, hsa-miR-4466, hsa-miR-4488, hsa-miR-67 at least one miR selected from the group consisting of miR-52-5p and hsa-miR-4739 iRNA can be used. Furthermore, these can be combined with miRNA. Other breast cancer markers, i.e., hsa-miR-760, hsa-miR-602, h sa-miR-423-5p, hsa-miR-92a-2-5p, hsa-miR-1 6-5p, hsa-miR-451a, hsa-miR-135a-3p, hsa-mi R-486-5p, hsa-miR-4257, hsa-miR-92b-5p, hsa -miR-1915-3p, hsa-miR-718, hsa-miR-940, hsa -miR-296-5p, hsa-miR-23b-3p and hsa-miR-92a- At least one miRNA selected from the group consisting of 3p is also preferably used as the target nucleic acid. Furthermore, other breast cancer miRNAs that can be combined with these miRNAs can be used. hsa-miR-658, hsa-miR-6842-5p, hsa -miR-6124, hsa-miR-6765-3p, hsa-miR-7106-5 p, hsa-miR-4534, hsa-miR-92b-3p, hsa-miR-31 35b, hsa-miR-4687-3p, hsa-miR-762, hsa-miR- 3619-3p, hsa-miR-4467, hsa-miR-557, hsa-miR -1237-5p, hsa-miR-1908-5p, hsa-miR-4286, hs a-miR-6885-5p and hsa-miR-6763-5p At least one miRNA that is expressed in a specific region can also be preferably used as a target nucleic acid.

[0362] The above miRNAs include, for example, any of SEQ ID NOs: 1 to 269 and 851 to 856. Human genes containing the base sequences represented by the miR-4783- 3p, hsa-miR-4730, hsa-miR-1307-3p, hsa-miR- 4634, hsa-miR-663a, hsa-miR-4532, hsa-miR-7 704, hsa-miR-3178, hsa-miR-6729-5p, hsa-miR -6090, hsa-miR-4732-5p, hsa-miR-3184-5p, hs a-miR-6727-5p, hsa-miR-6088, hsa-miR-4674, hsa-miR-8073, hsa-miR-4787-5p, hsa-miR-146 9, hsa-miR-125a-3p, hsa-miR-1233-5p, hsa-mi R-885-3p, hsa-miR-6802-5p, hsa-miR-328-5p, hsa-miR-6787-5p、hsa-miR-8069、hsa-miR-687 5-5p、hsa-miR-1246、hsa-miR-4734、hsa-miR-6 757-5p、hsa-miR-6756-5p、hsa-miR-3665、hsa- miR-6836-3p、hsa-miR-6821-5p、hsa-miR-6805 -5p、hsa-miR-4728-5p、hsa-miR-6726-5p、hsa- miR-197-5p、hsa-miR-149-3p、hsa-miR-6850-5 p、hsa-miR-4476、hsa-miR-6858-5p、hsa-miR-5 64, hsa-miR-4763-3p, hsa-miR-575, hsa-miR-6 771-5p、hsa-miR-1231、hsa-miR-1908-3p、hsa- miR-150-3p、hsa-miR-3937、hsa-miR-887-3p、h sa-miR-3940-5p、hsa-miR-4741、hsa-miR-6808 -5p、hsa-miR-6869-5p、hsa-miR-5090、hsa-miR -615-5p、hsa-miR-8072、hsa-miR-128-1-5p、hs a-miR-1238-5p、hsa-miR-365a-5p、hsa-miR-20 4-3p、hsa-miR-4492、hsa-miR-6785-5p、hsa-mi R-6511a-5p、hsa-miR-4525、hsa-miR-1915-5p、 hsa-miR-3180, hsa-miR-6879-5p, hsa-miR-119 9-5p、hsa-miR-6746-5p、hsa-miR-711、hsa-miR -663b、hsa-miR-4707-3p、hsa-miR-6893-5p、hs a-miR-4675、hsa-miR-4638-5p、hsa-miR-4651、 hsa-miR-6087, hsa-miR-4665-5p, hsa-miR-475 8-5p、hsa-miR-6887-5p、hsa-miR-3620-5p、hsa -miR-1909-3p、hsa-miR-7641、hsa-miR-6724-5 p、hsa-miR-1343-3p、hsa-miR-6780b-5p、hsa-m iR-4484、hsa-miR-4690-5p、hsa-miR-4429、hsa -miR-1227-5p、hsa-miR-4725-3p、hsa-miR-686 1-5p、hsa-miR-6812-5p、hsa-miR-3197、hsa-mi R-8059, hsa-miR-3185, hsa-miR-4706, hsa-miR -4497、hsa-miR-3131、hsa-miR-6806-5p、hsa-m iR-187-5p、hsa-miR-3180-3p、hsa-miR-6848-5 p、hsa-miR-6820-5p、hsa-miR-6800-5p、hsa-mi R-6717-5p、hsa-miR-6795-5p、hsa-miR-4632-5 p、hsa-miR-665、hsa-miR-6778-5p、hsa-miR-36 63-3p、hsa-miR-4689、hsa-miR-211-3p、hsa-mi R-6511b-5p、hsa-miR-4750-5p、hsa-miR-6126、 hsa-miR-614、hsa-miR-7110-5p、hsa-miR-744- 5p、hsa-miR-6769a-5p、hsa-miR-4792、hsa-miR -5787、hsa-miR-6798-5p、hsa-miR-6781-5p、hs a-miR-4419b、hsa-miR-4446-3p、hsa-miR-4259 hsa-miR-5572, hsa-miR-6075, hsa-miR-296-3 p、hsa-miR-6891-5p、hsa-miR-4745-5p、hsa-mi R-6775-5p、hsa-miR-6870-5p、hsa-miR-920、hs a-miR-4530、hsa-miR-6819-5p、hsa-miR-6825- 5p、hsa-miR-7847-3p、hsa-miR-6131、hsa-miR- 4433-3p、hsa-miR-1228-5p、hsa-miR-6743-5p、 hsa-miR-1268a、hsa-miR-3917、hsa-miR-6786- 5p、hsa-miR-3154、hsa-miR-638、hsa-miR-6741 -5p、hsa-miR-6889-5p、hsa-miR-6840-3p、hsa- miR-6510-5p、hsa-miR-3188、hsa-miR-551b-5p hsa-miR-5001-5p, hsa-miR-1268b, hsa-miR-7 107-5p、hsa-miR-6824-5p、hsa-miR-6732-5p、h sa-miR-371a-5p、hsa-miR-6794-5p、hsa-miR-6 779-5p、hsa-miR-4271、hsa-miR-5195-3p、hsa- miR-6762-5p、hsa-miR-939-5p、hsa-miR-1247- 3p、hsa-miR-6777-5p、hsa-miR-6722-3p、hsa-m iR-3656、hsa-miR-4688、hsa-miR-3195、hsa-mi R-6766-5p、hsa-miR-4447、hsa-miR-4656、hsa- miR-7108-5p、hsa-miR-3191-3p、hsa-miR-1273 g-3p, hsa-miR-4463, hsa-miR-2861, hsa-miR-3 196、hsa-miR-6877-5p、hsa-miR-3679-5p、hsa- miR-4442, hsa-miR-6789-5p, hsa-miR-6782-5p hsa-miR-486-3p, hsa-miR-6085, hsa-miR-474 6-3p、hsa-miR-619-5p、hsa-miR-937-5p、hsa-m iR-6803-5p、hsa-miR-4298、hsa-miR-4454、hsa -miR-4459、hsa-miR-7150、hsa-miR-6880-5p、h sa-miR-4449、hsa-miR-8063、hsa-miR-4695-5p hsa-miR-6132, hsa-miR-6829-5p, hsa-miR-44 86、hsa-miR-6805-3p、hsa-miR-6826-5p、hsa-m iR-4508、hsa-miR-1343-5p、hsa-miR-7114-5p、 hsa-miR-3622a-5p、hsa-miR-6765-5p、hsa-miR -7845-5p、hsa-miR-3960、hsa-miR-6749-5p、hs a-miR-1260b、hsa-miR-6799-5p、hsa-miR-4723 -5p、hsa-miR-6784-5p、hsa-miR-5100、hsa-miR -6769b-5p、hsa-miR-1207-5p、hsa-miR-642a-3 p, hsa-miR-4505, hsa-miR-4270, hsa-miR-6721 -5p, hsa-miR-7111-5p, hsa-miR-6791-5p, hsa- miR-7109-5p, hsa-miR-4258, hsa-miR-6515-3p , hsa-miR-6851-5p, hsa-miR-6125, hsa-miR-47 49-5p, hsa-miR-4726-5p, hsa-miR-4513, hsa-m iR-6089, hsa-miR-6816-5p, hsa-miR-4466, hsa -miR-4488, hsa-miR-6752-5p, hsa-miR-4739, h sa-miR-760, hsa-miR-602, hsa-miR-423-5p, hs a-miR-92a-2-5p, hsa-miR-16-5p, hsa-miR-451 a, hsa-miR-135a-3p, hsa-miR-486-5p, hsa-miR -4257, hsa-miR-92b-5p, hsa-miR-1915-3p, hsa -miR-718, hsa-miR-940, hsa-miR-296-5p, hsa- miR-23b-3p, hsa-miR-92a-3p, hsa-miR-658, hs a-miR-6842-5p, hsa-miR-6124, hsa-miR-6765- 3p, hsa-miR-7106-5p, hsa-miR-4534, hsa-miR- 92b-3p, hsa-miR-3135b, hsa-miR-4687-3p, hsa -miR-762, hsa-miR-3619-3p, hsa-miR-4467, hs a-miR-557, hsa-miR-1237-5p, hsa-miR-1908-5 p, hsa-miR-4286, hsa-miR-6885-5p and hsa-miR- 6763-5p), its homologs, its transcription products, and its variants or derivatives. Here, the terms gene, homologue, transcription product, variant and derivative are as defined above.

[0363] A preferred target nucleic acid is a human gene comprising a base sequence represented by any one of SEQ ID NOs: 1 to 871. A gene or its transcription product, more preferably, the transcription product, i.e., miRNA, The miRNA is a precursor RNA of the miRNA, pri-miRNA or pre-miRNA.

[0364] The first target gene is the hsa-miR-4783-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0365] The second target gene is the hsa-miR-4730 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0366] The third target gene is the hsa-miR-1307-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0367] The fourth target gene is the hsa-miR-4634 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0368] The fifth target gene is the hsa-miR-663a gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0369] The sixth target gene is the hsa-miR-4532 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0370] The seventh target gene is the hsa-miR-7704 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0371] The eighth target gene is the hsa-miR-3178 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0372] The ninth target gene is the hsa-miR-6729-5p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0373] The tenth target gene is the hsa-miR-6090 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0374] The eleventh target gene is the hsa-miR-4732-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0375] The 12th target gene is the hsa-miR-3184-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0376] The 13th target gene is the hsa-miR-6727-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0377] The 14th target gene is the hsa-miR-6088 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0378] The 15th target gene is the hsa-miR-4674 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0379] The 16th target gene is the hsa-miR-8073 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0380] The 17th target gene is the hsa-miR-4787-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0381] The 18th target gene is the hsa-miR-1469 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0382] The 19th target gene is the hsa-miR-125a-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0383] The 20th target gene is the hsa-miR-1233-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0384] The 21st target gene is the hsa-miR-885-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0385] The 22nd target gene is the hsa-miR-6802-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0386] The 23rd target gene is the hsa-miR-328-5p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0387] The 24th target gene is the hsa-miR-6787-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0388] The 25th target gene is the hsa-miR-8069 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0389] The 26th target gene is the hsa-miR-6875-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0390] The 27th target gene is the hsa-miR-1246 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0391] The 28th target gene is the hsa-miR-4734 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0392] The 29th target gene is the hsa-miR-6757-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0393] The 30th target gene is the hsa-miR-6756-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0394] The 31st target gene is the hsa-miR-3665 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0395] The 32nd target gene is the hsa-miR-6836-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0396] The 33rd target gene is the hsa-miR-6821-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0397] The 34th target gene is the hsa-miR-6805-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0398] The 35th target gene is the hsa-miR-4728-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0399] The 36th target gene is the hsa-miR-6726-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0400] The 37th target gene is the hsa-miR-197-5p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0401] The 38th target gene is the hsa-miR-149-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0402] The 39th target gene is the hsa-miR-6850-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0403] The 40th target gene is the hsa-miR-4476 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0404] The 41st target gene is the hsa-miR-6858-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0405] The 42nd target gene is the hsa-miR-564 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0406] The 43rd target gene is the hsa-miR-4763-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0407] The 44th target gene is the hsa-miR-575 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0408] The 45th target gene is the hsa-miR-6771-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0409] The 46th target gene is the hsa-miR-1231 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0410] The 47th target gene is the hsa-miR-1908-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0411] The 48th target gene is the hsa-miR-150-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0412] The 49th target gene is the hsa-miR-3937 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0413] The 50th target gene is the hsa-miR-887-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0414] The 51st target gene is the hsa-miR-3940-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0415] The 52nd target gene is the hsa-miR-4741 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0416] The 53rd target gene is the hsa-miR-6808-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0417] The 54th target gene is the hsa-miR-6869-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0418] The 55th target gene is the hsa-miR-5090 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0419] The 56th target gene is the hsa-miR-615-5p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0420] The 57th target gene is the hsa-miR-8072 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0421] The 58th target gene is the hsa-miR-128-1-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0422] The 59th target gene is the hsa-miR-1238-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0423] The 60th target gene is the hsa-miR-365a-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0424] The 61st target gene is the hsa-miR-204-3p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0425] The 62nd target gene is the hsa-miR-4492 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0426] The 63rd target gene is the hsa-miR-6785-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0427] The 64th target gene is the hsa-miR-6511a-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0428] The 65th target gene is the hsa-miR-4525 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0429] The 66th target gene is the hsa-miR-1915-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0430] The 67th target gene is the hsa-miR-3180 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0431] The 68th target gene is the hsa-miR-6879-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0432] The 69th target gene is the hsa-miR-1199-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0433] The 70th target gene is the hsa-miR-6746-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0434] The 71st target gene is the hsa-miR-711 gene, its homologs, and their transcription factors. The gene or its transcript, or a variant or derivative thereof, has not been There are no known reports that altered expression of these proteins could be markers for breast cancer.

[0435] The 72nd target gene is the hsa-miR-663b gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0436] The 73rd target gene is the hsa-miR-4707-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0437] The 74th target gene is the hsa-miR-6893-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0438] The 75th target gene is the hsa-miR-4675 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0439] The 76th target gene is the hsa-miR-4638-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0440] The 77th target gene is the hsa-miR-4651 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0441] The 78th target gene is the hsa-miR-6087 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0442] The 79th target gene is the hsa-miR-4665-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0443] The 80th target gene is the hsa-miR-4758-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0444] The 81st target gene is the hsa-miR-6887-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0445] The 82nd target gene is the hsa-miR-3620-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0446] The 83rd target gene is the hsa-miR-1909-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0447] The 84th target gene is the hsa-miR-7641 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0448] The 85th target gene is the hsa-miR-6724-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0449] The 86th target gene is the hsa-miR-1343-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0450] The 87th target gene is the hsa-miR-6780b-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0451] The 88th target gene is the hsa-miR-4484 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0452] The 89th target gene is the hsa-miR-4690-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0453] The 90th target gene is the hsa-miR-4429 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0454] The 91st target gene is the hsa-miR-1227-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0455] The 92nd target gene is the hsa-miR-4725-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0456] The 93rd target gene is the hsa-miR-6861-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0457] The 94th target gene is the hsa-miR-6812-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0458] The 95th target gene is the hsa-miR-3197 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0459] The 96th target gene is the hsa-miR-8059 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0460] The 97th target gene is the hsa-miR-3185 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0461] The 98th target gene is the hsa-miR-4706 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0462] The 99th target gene is the hsa-miR-4497 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0463] The 100th target gene is the hsa-miR-3131 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0464] The 101st target gene is the hsa-miR-6806-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0465] The 102nd target gene is the hsa-miR-187-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0466] The 103rd target gene is the hsa-miR-3180-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0467] The 104th target gene is the hsa-miR-6848-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0468] The 105th target gene is the hsa-miR-6820-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0469] The 106th target gene is the hsa-miR-6800-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0470] The 107th target gene is the hsa-miR-6717-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0471] The 108th target gene is the hsa-miR-6795-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0472] The 109th target gene is the hsa-miR-4632-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0473] The 110th target gene is the hsa-miR-665 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0474] The 111th target gene is the hsa-miR-6778-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0475] The 112th target gene is the hsa-miR-3663-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0476] The 113th target gene is the hsa-miR-4689 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0477] The 114th target gene is the hsa-miR-211-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0478] The 115th target gene is the hsa-miR-6511b-5p gene and its homologs , their transcription products, or their mutants or derivatives. There are no known reports that altered expression of its transcripts can be a marker for breast cancer. .

[0479] The 116th target gene is the hsa-miR-4750-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0480] The 117th target gene is the hsa-miR-6126 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0481] The 118th target gene is the hsa-miR-614 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0482] The 119th target gene is the hsa-miR-7110-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0483] The 120th target gene is the hsa-miR-744-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0484] The 121st target gene is the hsa-miR-6769a-5p gene and its homologs , their transcription products, or their mutants or derivatives. There are no known reports that altered expression of its transcripts can be a marker for breast cancer. .

[0485] The 122nd target gene is the hsa-miR-4792 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0486] The 123rd target gene is the hsa-miR-5787 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0487] The 124th target gene is the hsa-miR-6798-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0488] The 125th target gene is the hsa-miR-6781-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0489] The 126th target gene is the hsa-miR-4419b gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0490] The 127th target gene is the hsa-miR-4446-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0491] The 128th target gene is the hsa-miR-4259 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0492] The 129th target gene is the hsa-miR-5572 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0493] The 130th target gene is the hsa-miR-6075 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0494] The 131st target gene is the hsa-miR-296-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0495] The 132nd target gene is the hsa-miR-6891-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0496] The 133rd target gene is the hsa-miR-4745-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0497] The 134th target gene is the hsa-miR-6775-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0498] The 135th target gene is the hsa-miR-6870-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0499] The 136th target gene is the hsa-miR-920 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0500] The 137th target gene is the hsa-miR-4530 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0501] The 138th target gene is the hsa-miR-6819-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0502] The 139th target gene is the hsa-miR-6825-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0503] The 140th target gene is the hsa-miR-7847-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0504] The 141st target gene is the hsa-miR-6131 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0505] The 142nd target gene is the hsa-miR-4433-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0506] The 143rd target gene is the hsa-miR-1228-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0507] The 144th target gene is the hsa-miR-6743-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0508] The 145th target gene is the hsa-miR-1268a gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0509] The 146th target gene is the hsa-miR-3917 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0510] The 147th target gene is the hsa-miR-6786-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0511] The 148th target gene is the hsa-miR-3154 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0512] The 149th target gene is the hsa-miR-638 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0513] The 150th target gene is the hsa-miR-6741-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0514] The 151st target gene is the hsa-miR-6889-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0515] The 152nd target gene is the hsa-miR-6840-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0516] The 153rd target gene is the hsa-miR-6510-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0517] The 154th target gene is the hsa-miR-3188 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0518] The 155th target gene is the hsa-miR-551b-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0519] The 156th target gene is the hsa-miR-5001-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0520] The 157th target gene is the hsa-miR-1268b gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0521] The 158th target gene is the hsa-miR-7107-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0522] The 159th target gene is the hsa-miR-6824-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0523] The 160th target gene is the hsa-miR-6732-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0524] The 161st target gene is the hsa-miR-371a-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0525] The 162nd target gene is the hsa-miR-6794-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0526] The 163rd target gene is the hsa-miR-6779-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0527] The 164th target gene is the hsa-miR-4271 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0528] The 165th target gene is the hsa-miR-5195-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0529] The 166th target gene is the hsa-miR-6762-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0530] The 167th target gene is the hsa-miR-939-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0531] The 168th target gene is the hsa-miR-1247-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0532] The 169th target gene is the hsa-miR-6777-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0533] The 170th target gene is the hsa-miR-6722-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0534] The 171st target gene is the hsa-miR-3656 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0535] The 172nd target gene is the hsa-miR-4688 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0536] The 173rd target gene is the hsa-miR-3195 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0537] The 174th target gene is the hsa-miR-6766-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0538] The 175th target gene is the hsa-miR-4447 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0539] The 176th target gene is the hsa-miR-4656 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0540] The 177th target gene is the hsa-miR-7108-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0541] The 178th target gene is the hsa-miR-3191-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0542] The 179th target gene is the hsa-miR-1273g-3p gene and its homologs. , their transcription products, or their mutants or derivatives. There are no known reports that altered expression of its transcripts can be a marker for breast cancer. .

[0543] The 180th target gene is the hsa-miR-4463 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0544] The 181st target gene is the hsa-miR-2861 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0545] The 182nd target gene is the hsa-miR-3196 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0546] The 183rd target gene is the hsa-miR-6877-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0547] The 184th target gene is the hsa-miR-3679-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0548] The 185th target gene is the hsa-miR-4442 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0549] The 186th target gene is the hsa-miR-6789-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0550] The 187th target gene is the hsa-miR-6782-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0551] The 188th target gene is the hsa-miR-486-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0552] The 189th target gene is the hsa-miR-6085 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0553] The 190th target gene is the hsa-miR-4746-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0554] The 191st target gene is the hsa-miR-619-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0555] The 192nd target gene is the hsa-miR-937-5p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0556] The 193rd target gene is the hsa-miR-6803-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0557] The 194th target gene is the hsa-miR-4298 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0558] The 195th target gene is the hsa-miR-4454 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0559] The 196th target gene is the hsa-miR-4459 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0560] The 197th target gene is the hsa-miR-7150 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0561] The 198th target gene is the hsa-miR-6880-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0562] The 199th target gene is the hsa-miR-4449 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0563] The 200th target gene is the hsa-miR-8063 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0564] The 201st target gene is the hsa-miR-4695-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0565] The 202nd target gene is the hsa-miR-6132 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0566] The 203rd target gene is the hsa-miR-6829-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0567] The 204th target gene is the hsa-miR-4486 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0568] The 205th target gene is the hsa-miR-6805-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0569] The 206th target gene is the hsa-miR-6826-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0570] The 207th target gene is the hsa-miR-4508 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0571] The 208th target gene is the hsa-miR-1343-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0572] The 209th target gene is the hsa-miR-7114-5p gene, its homologs, The genes or their transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0573] The 210th target gene is the hsa-miR-3622a-5p gene and its homologs , their transcription products, or their mutants or derivatives. There are no known reports that altered expression of its transcripts can be a marker for breast cancer. .

[0574] The 211th target gene is the hsa-miR-6765-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0575] The 212th target gene is the hsa-miR-7845-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0576] The 213th target gene is the hsa-miR-3960 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0577] The 214th target gene is the hsa-miR-6749-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0578] The 215th target gene is the hsa-miR-1260b gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0579] The 216th target gene is the hsa-miR-6799-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0580] The 217th target gene is the hsa-miR-4723-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0581] The 218th target gene is the hsa-miR-6784-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0582] The 219th target gene is the hsa-miR-5100 gene, its homologs, and its The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0583] The 220th target gene is the hsa-miR-6769b-5p gene and its homologs , their transcription products, or their mutants or derivatives. There are no known reports that altered expression of its transcripts can be a marker for breast cancer. .

[0584] The 221st target gene is the hsa-miR-1207-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0585] The 222nd target gene is the hsa-miR-642a-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0586] The 223rd target gene is the hsa-miR-4505 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0587] The 224th target gene is the hsa-miR-4270 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0588] The 225th target gene is the hsa-miR-6721-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0589] The 226th target gene is the hsa-miR-7111-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0590] The 227th target gene is the hsa-miR-6791-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0591] The 228th target gene is the hsa-miR-7109-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0592] The 229th target gene is the hsa-miR-4258 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0593] The 230th target gene is the hsa-miR-6515-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0594] The 231st target gene is the hsa-miR-6851-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0595] The 232nd target gene is the hsa-miR-6125 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0596] The 233rd target gene is the hsa-miR-4749-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0597] The 234th target gene is the hsa-miR-4726-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0598] The 235th target gene is the hsa-miR-4513 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0599] The 236th target gene is the hsa-miR-760 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. It has been reported that changes in the expression of these products can be markers for breast cancer (see the above non-specific Reference 3).

[0600] The 237th target gene is the hsa-miR-602 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. It has been reported that changes in the expression of the product can be a marker for breast cancer (see the above patent). Reference 1).

[0601] The 238th target gene is the hsa-miR-423-5p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Non-patent document 4).

[0602] The 239th target gene is the hsa-miR-92a-2-5p gene and its homologs. , their transcription products, or their mutants or derivatives. It has been reported that changes in the expression of its transcripts can be a marker for breast cancer ( The above-mentioned patent document 3).

[0603] The 240th target gene is the hsa-miR-16-5p gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. It has been reported that changes in transcript expression can be a marker for breast cancer (see above). Patent document 4).

[0604] The 241st target gene is the hsa-miR-451a gene, its homologs, and their The gene or its transcription product, or its variant or derivative. It has been reported that changes in the expression of transcripts can be markers for breast cancer (see above). Permitted document 4).

[0605] The 242nd target gene is the hsa-miR-135a-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. It has been reported that changes in the expression of its transcripts can be a marker for breast cancer (see above). The above-mentioned Patent Documents 1 and 2).

[0606] The 243rd target gene is the hsa-miR-486-5p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Non-patent document 4).

[0607] The 244th target gene is the hsa-miR-4257 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. It has been reported that changes in the expression of transcripts can be markers for breast cancer (see the above non- Patent document 5).

[0608] The 245th target gene is the hsa-miR-92b-5p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Patent document 3).

[0609] The 246th target gene is the hsa-miR-1915-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. It has been reported that changes in the expression of its transcripts can be a marker for breast cancer (see above). See the above non-patent document 5).

[0610] The 247th target gene is the hsa-miR-718 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. It has been reported that changes in the expression of these products can be markers for breast cancer (see the above non-specific Permitted document 5).

[0611] The 248th target gene is the hsa-miR-940 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. It has been reported that changes in the expression of these products can be markers for breast cancer (see the above non-specific Reference 6).

[0612] The 249th target gene is the hsa-miR-296-5p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Patent document 4).

[0613] The 250th target gene is the hsa-miR-23b-3p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Patent document 2).

[0614] The 251st target gene is the hsa-miR-92a-3p gene, its homologs, and These are transcription products, or their variants or derivatives. It has been reported that changes in the expression of the transcripts of these genes can be a marker for breast cancer (see above). Patent document 3).

[0615] The 252nd target gene is the hsa-miR-658 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0616] The 253rd target gene is the hsa-miR-6842-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0617] The 254th target gene is the hsa-miR-6124 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0618] The 255th target gene is the hsa-miR-6765-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0619] The 256th target gene is the hsa-miR-7106-5p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0620] The 257th target gene is the hsa-miR-4534 gene, its homologs, and their The gene or its transcription product, or its variant or derivative. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0621] The 258th target gene is the hsa-miR-92b-3p gene, its homologs, and These are transcription products, or their variants or derivatives. There are no known reports that altered expression of this transcript could be a marker for breast cancer.

[0622] The 259th target gene is the hsa-miR-3135b gene, its homologs, and The gene is a transcription product of the gene, or a variant or derivative thereof. There are no known reports that altered transcript expression can be a marker for breast cancer.

[0623] The 260th target gene is the hsa-miR-4687-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0624] The 261st target gene is the hsa-miR-762 gene, its homologs, and their The gene or its transcription product, or a variant or derivative thereof. There are no known reports that altered expression of these products could be a marker for breast cancer.

[0625] The 262nd target gene is the hsa-miR-3619-3p gene, its homologs, The gene is a transcription product thereof, or a variant or derivative thereof. There are no known reports suggesting that changes in the expression of its transcripts could be a marker for breast cancer.

[0626] The 263rd target gene is th...

Claims

1. A kit for detecting breast cancer, comprising a nucleic acid capable of specifically binding to miR-1233-5p, a breast cancer marker.

2. The nucleic acid A polynucleotide or a fragment thereof shown in any one of (1) to (5) below: (1) A polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (2) A polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (1), (3) The polynucleotide of (1) or (2) or a fragment thereof containing a modified nucleic acid and / or a modified nucleotide; (4) A polynucleotide containing a base sequence complementary to the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (5) A polynucleotide that hybridizes under highly stringent conditions with any one of the following polynucleotides (a) to (d) or a fragment thereof: (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (b) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (a); (c) a polynucleotide of (a) or (b) or a fragment thereof comprising modified nucleic acids and / or modified nucleotides; and (d) a polynucleotide containing the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; 2. The kit of claim 1, wherein the kit is selected from the group consisting of:

3. The kit includes other breast cancer markers, namely miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p, miR-6812-5pmiR-3197、miR-8059、miR-3185、miR-4706、miR-4497、miR-3131、miR-6806 -5p、miR-187-5p、miR-3180-3p、miR-6848-5p、miR-6800-5p、 miR-6717-5p、miR-6795-5p、miR-4632-5p、miR-6778-5p、miR-3663-3p、mi R-4689、miR-211-3p、miR-6511b-5p、miR-4750-5p、miR-6126、miR-614、miR -7110-5p、miR-744-5p、miR-6769a-5p、miR-4792、miR-5787、miR-6798-5p 、miR-6781-5p、miR-4419b、miR-4446-3p、miR-4259、miR-5572、miR-6075、m iR-296-3p、miR-6891-5p、miR-4745-5p、miR-6770-5p、miR- 920、miR-4530、miR-6819-5p、miR-6825-5p、miR-7847-3p、miR-6131、miR-4 433-3p、miR-1228-5p、miR-6743-5p、miR-1268a、miR-3917、miR-6786-5p、 miR-3154、miR-638、miR-6741-5p、miR-6889-5p、miR-6840-3p、miR-6510-� p、miR-3188、miR-551b-5p、miR-5001-5p、miR-1268b、miR-7107-5p、miR-6 824-5p、miR-6732-5p、miR-371a-5p、miR-6794-5p、miR-4271 、miR-5195-3p、miR-6762-5p、miR-1247-3p、miR-6777-5p、mi R-6722-3p、miR-3656、miR-4688、miR-3195、miR-6766-5p、miR-4447、miR-4 656、miR-7108-5p、miR-3191-3p、miR-1273g-3p、miR-4463、miR-2861、miR -3196、miR-6877-5p、miR-3679-5p、miR-6782-5p、miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803 -5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, m iR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR-6 765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p, miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR- 642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749- 5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-4488 , miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p, miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, mi The kit according to claim 1 or 2, further comprising a nucleic acid capable of specifically binding to at least one polynucleotide selected from the group consisting of miR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p, and miR-6763-5p.

4. The nucleic acid is a polynucleotide or a fragment thereof shown in any one of (6) to (10) below: (6) A polynucleotide consisting of a base sequence complementary to any of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases; (7) A polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof according to (6). (8) A polynucleotide or a fragment thereof according to (6) or (7) containing a modified nucleic acid and / or a modified nucleotide. (9) A polynucleotide containing a base sequence complementary to any of the base sequences represented by SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (10) A polynucleotide that hybridizes under highly stringent conditions with any one of the following polynucleotides (e) to (h) or a fragment thereof: (e) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases; (f) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (e); (g) a polynucleotide or fragment thereof of (e) or (f) comprising modified nucleic acids and / or modified nucleotides; and (h) a polynucleotide containing a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases The kit of claim 3, wherein the kit is selected from the group consisting of:

5. A device for detecting breast cancer, comprising a nucleic acid capable of specifically binding to miR-1233-5p, a breast cancer marker.

6. The nucleic acid A polynucleotide or a fragment thereof shown in any one of (1) to (5) below: (1) A polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (2) A polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (1), (3) The polynucleotide of (1) or (2) or a fragment thereof containing a modified nucleic acid and / or a modified nucleotide; (4) A polynucleotide containing a base sequence complementary to the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (5) A polynucleotide that hybridizes under highly stringent conditions with any one of the following polynucleotides (a) to (d) or a fragment thereof: (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; (b) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (a); (c) a polynucleotide of (a) or (b) or a fragment thereof comprising modified nucleic acids and / or modified nucleotides; and (d) a polynucleotide containing the base sequence represented by SEQ ID NO: 20 or the base sequence in which u is t, or a fragment thereof containing 15 or more consecutive bases; 6. The device of claim 5, selected from the group consisting of:

7. The device is another breast cancer marker, miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p, miR-6812-5p,miR-3197、miR-8059、miR-3185、miR-4706、miR-4497、miR-3131、miR-6806 -5p、miR-187-5p、miR-3180-3p、miR-6848-5p、miR-6800-5p、 miR-6717-5p、miR-6795-5p、miR-4632-5p、miR-6778-5p、miR-3663-3p、mi R-4689、miR-211-3p、miR-6511b-5p、miR-4750-5p、miR-6126、miR-614、miR -7110-5p、miR-744-5p、miR-6769a-5p、miR-4792、miR-5787、miR-6798-5p 、miR-6781-5p、miR-4419b、miR-4446-3p、miR-4259、miR-5572、miR-6075、m iR-296-3p、miR-6891-5p、miR-4745-5p、miR-6770-5p、miR- 920、miR-4530、miR-6819-5p、miR-6825-5p、miR-7847-3p、miR-6131、miR-4 433-3p、miR-1228-5p、miR-6743-5p、miR-1268a、miR-3917、miR-6786-5p、 miR-3154、miR-638、miR-6741-5p、miR-6889-5p、miR-6840-3p、miR-6510-� p、miR-3188、miR-551b-5p、miR-5001-5p、miR-1268b、miR-7107-5p、miR-6 824-5p、miR-6732-5p、miR-371a-5p、miR-6794-5p、miR-4271 、miR-5195-3p、miR-6762-5p、miR-1247-3p、miR-6777-5p、mi R-6722-3p、miR-3656、miR-4688、miR-3195、miR-6766-5p、miR-4447、miR-4 656、miR-7108-5p、miR-3191-3p、miR-1273g-3p、miR-4463、miR-2861、miR -3196、miR-6877-5p、miR-3679-5p、miR-6782-5p、miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803 -5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, m iR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR-6 765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p, miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR- 642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p, miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749- 5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-4488 , miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p, miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p, miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, mi The device according to claim 5 or 6, further comprising a nucleic acid capable of specifically binding to at least one polynucleotide selected from the group consisting of miR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p and miR-6763-5p.

8. The nucleic acid is a polynucleotide or a fragment thereof shown in any one of (6) to (10) below: (6) A polynucleotide consisting of a base sequence complementary to any of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases; (7) A polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof according to (6). (8) A polynucleotide or a fragment thereof according to (6) or (7) containing a modified nucleic acid and / or a modified nucleotide. (9) A polynucleotide comprising a base sequence complementary to any of the base sequences represented by SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or the base sequence in which u is t; and (10) A polynucleotide that hybridizes under highly stringent conditions with any one of the polynucleotides (e) to (h) or a fragment thereof. (e) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases; (f) a polynucleotide or a fragment thereof containing a deletion, substitution, addition, or insertion of one or two bases in the base sequence of the polynucleotide or a fragment thereof of (e); (g) a polynucleotide or fragment thereof of (e) or (f) comprising modified nucleic acids and / or modified nucleotides; and (h) a polynucleotide containing a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269, or a base sequence in which u is t in the base sequence, or a fragment thereof containing 15 or more consecutive bases; 8. The device of claim 7, selected from the group consisting of:

9. A method for assisting in the detection of breast cancer, which comprises using the kit according to any one of claims 1 to 4 or the device according to any one of claims 5 to 8 to measure the expression level of each target nucleic acid in a specimen from a subject, and comparing the measured expression levels with control expression levels from healthy subjects similarly measured, to determine whether a subject is suffering from breast cancer based on whether the expression level of the corresponding target nucleic acid in the subject is higher or lower than the expression level of each target nucleic acid in healthy subjects.

10. The method of claim 9, wherein the subject is a human.

11. The method of claim 9 or 10, wherein the sample is blood, serum, or plasma.

12. Use of miR-1233-5p as a breast cancer marker for the detection of breast cancer.

13. The use according to claim 12, wherein the miR-1233-5p is a polynucleotide shown in either (a) or (b) below: (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 20; (b) A polynucleotide comprising the base sequence represented by SEQ ID NO:

20.

14. The miR-1233-5p is miR-4783-3p, miR-1307-3p, miR-4634, miR-663a, miR-4532, miR-7704, miR-3178, miR-6729-5p, miR-6090, miR-4732-5p, miR-3184-5p, miR-6727-5p, miR-6088, miR-4674, miR-8073, miR-4787-5p, miR-1469, miR-125a-3p, miR-885-3p, miR-6802-5p, miR-328-5p, miR-6787-5p, miR-8069, miR-6875-5p, miR-1246, miR-4734, miR-6756-5p, miR-3665, miR-6821-5p, miR-6805-5p, miR-4728-5p, miR-6726-5p, miR-197-5p, miR-149-3p, miR-6850-5p, miR-4476, miR-6858-5p, miR-564, miR-4763-3p, miR-575, miR-6771-5p, miR-1231, miR-1908-3p, miR-150-3p, miR-3937, miR-887-3p, miR-3940-5p, miR-4741, miR-6808-5p, miR-6869-5p, miR-5090, miR-615-5p, miR-8072, miR-128-1-5p, miR-1238-5p, miR-365a-5p, miR-204-3p, miR-4492, miR-6785-5p, miR-6511a-5p, miR-4525, miR-1915-5p, miR-3180, miR-6879-5p, miR-1199-5p, miR-6746-5p, miR-711, miR-663b, miR-4707-3p, miR-6893-5p, miR-4675, miR-4638-5p, miR-4651, miR-6087, miR-4665-5p, miR-4758-5p, miR-6887-5p, miR-3620-5p, miR-1909-3p, miR-7641, miR-6724-5p, miR-1343-3p, miR-6780b-5p, miR-4484, miR-4690-5p, miR-4429, miR-1227-5p, miR-4725-3p, miR-6861-5p, miR-6812-5p, miR-3197,miR-8059、miR-3185、miR-4706、miR-4497、miR-3131、miR-6806-5p、miR- 187-5p、miR-3180-3p、miR-6848-5p、miR-6820-5p、miR-6800-5p、miR-671 7-5p、miR-6795-5p、miR-4632-5p、miR-6778-5p、miR-3663-3p、miR-4689、 miR-211-3p、miR-6511b-5p、miR-470-5p、miR-6126、miR-614、miR-7110- 5p、miR-744-5p、miR-6769a-5p、miR-4792、miR-5787、miR-6798-5p、miR-6 781-5p、miR-4419b、miR-4446-3p、miR-4259、miR-5572、miR-6075、miR-29 6-3p、miR-6891-5p、miR-4745-5p、miR-6775-5p、miR-920、m iR-4530、miR-6819-5p、miR-6825-5p、miR-7847-3p、miR-6131、miR-4433- 3p、miR-1228-5p、miR-6743-5p、miR-1268a、miR-3917、miR-6786-5p、miR- 3154、miR-638、miR-6741-5p、miR-6889-5p、miR-6840-3p、miR-6510-5p、m iR-3188、miR-551b-5p、miR-5001-5p、miR-1268b、miR-7107-5p、miR-6824 -5p、miR-6732-5p、miR-371a-5p、miR-6794-5p、miR-4271、m iR-5195-3p、miR-6762-5p、miR-1247-3p、miR-6777-5p、miR- 6722-3p、miR-3656、miR-4688、miR-3195、miR-6766-5p、miR-4447、miR-46 56、miR-7108-5p、miR-3191-3p、miR-1273g-3p、miR-4463、miR-2861、miR- 3196、miR-6877-5p、miR-3679-5p、miR-442、miR-6782-5p、miR-486-3p, miR-6085, miR-4746-3p, miR-619-5p, miR-937-5p, miR-6803 -5p, miR-4298, miR-4454, miR-4459, miR-7150, miR-6880-5p, miR-4449, m iR-8063, miR-4695-5p, miR-6132, miR-6829-5p, miR-4486, miR-6805-3p, miR-6826-5p, miR-4508, miR-1343-5p, miR-7114-5p, miR-3622a-5p, miR- 6765-5p, miR-7845-5p, miR-3960, miR-6749-5p, miR-1260b, miR-6799-5p , miR-4723-5p, miR-6784-5p, miR-5100, miR-6769b-5p, miR-1207-5p, miR -642a-3p, miR-4505, miR-4270, miR-6721-5p, miR-7111-5p, miR-6791-5p , miR-7109-5p, miR-4258, miR-6515-3p, miR-6851-5p, miR-6125, miR-4749 -5p, miR-4726-5p, miR-4513, miR-6089, miR-6816-5p, miR-4466, miR-448 8, miR-6752-5p, miR-4739, miR-760, miR-602, miR-423-5p, miR-92a-2-5p , miR-16-5p, miR-451a, miR-135a-3p, miR-486-5p, miR-4257, miR-92b-5p , miR-1915-3p, miR-718, miR-940, miR-296-5p, miR-23b-3p, miR-92a-3p, m and (c) a polynucleotide selected from the group consisting of iR-658, miR-6842-5p, miR-6124, miR-6765-3p, miR-7106-5p, miR-4534, miR-92b-3p, miR-3135b, miR-4687-3p, miR-762, miR-3619-3p, miR-4467, miR-557, miR-1237-5p, miR-1908-5p, miR-4286, miR-6885-5p, and miR-6763-5p, for use as a breast cancer marker for detecting breast cancer.Use according to claim 12 or 13.

15. The use according to claim 14, wherein the at least one polynucleotide is at least one selected from the group consisting of polynucleotides shown in either (c) or (d) below: (c) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269; (d) A polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1, 3 to 19, 21 to 28, 30, 31, 33 to 109, 111 to 235, 851 to 856, and 236 to 269.

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