Ferrocene-based phosphine derivative having adamantyl group and method for producing the same

A novel ferrocene-based phosphine derivative with an adamantyl group is synthesized via coupling reactions, addressing the lack of such ligands in existing technologies and improving catalytic activity and selectivity in coupling reactions.

JP2025128993APending Publication Date: 2025-09-03NIPPON CHEMICAL IND CO LTD
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Patent Information

Application Number
JP2024093746
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-02-22
Filing Date
2024-06-10
Publication Date
2025-09-03

AI Technical Summary

Technical Problem

There are few reports of metal complexes using ferrocene-based bidentate phosphine ligands with bulky substituents such as adamantyl groups, which are known to exhibit excellent catalytic activity in coupling reactions.

Method used

A novel ferrocene-based phosphine derivative having an adamantyl group is synthesized through a coupling reaction between a diiodoferrocene derivative and a diadamantylphosphine derivative, or by lithiating a dihalogenoferrocene and a diadamantyl halogenophosphine derivative, followed by further coupling reactions using transition metal catalysts and bases.

Benefits of technology

The resulting ferrocene-based phosphine derivative is expected to be useful as a ligand for coupling reaction catalysts, enhancing catalytic activity and reaction selectivity.

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Abstract

To provide a novel ferrocene-based phosphine derivative having an adamantyl group, which can be expected for use as a ligand for a coupling reaction catalyst, and a method for producing the same.SOLUTION: The present invention provides a ferrocene-based phosphine derivative having an adamantyl group, represented by the following general formula (1). (In the formula, R1 represents a group selected from alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, alkoxy and carbonyl groups; n represents an integer of 0 to 4; R3 represents a group selected from alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, alkoxy, carbonyl, amino, carboxyl, hydroxy and amide groups; and t represents an integer of 0 to 4.)SELECTED DRAWING: None
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Citation Information

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