Oral appliance cleaner for effervescent tablets

Abstract

To provide an oral appliance cleaner for effervescent tablets, which has excellent deodorizing properties, by using a novel formulation technology.SOLUTION: The oral appliance cleanser for effervescent tablets of the present disclosure (excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried Piper betle leaves, those containing an extract extracted from fresh or dried Punica granatum fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate) comprises (A) cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates, and (C) an effervescent agent, the effervescent agent (C) being a combination of a carbonate and an acid.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present disclosure relates to an oral instrument cleanser for effervescent tablets that has excellent deodorizing effects. [Background technology]

[0002] Dentures and other oral appliances are prone to the accumulation of bacteria, biofilms, and other deposits, and if left uncleaned, this can not only cause bad breath but can also contribute to the development of oral diseases such as periodontal disease. Therefore, cleaning oral appliances and keeping them clean is essential as part of oral care. Because bacteria and dirt adhering to oral appliances cannot be sufficiently removed by brushing, cleaning with a detergent is important.

[0003] Cleaning of intraoral appliances with a detergent is generally carried out by adding the detergent to water to prepare cleaning water, and then immersing the intraoral appliances in the water. Conventionally, intraoral appliance cleaners have been formulated with surfactants and foaming agents (carbonates and acids), and are designed to enhance cleaning effectiveness by exerting chemical cleaning power through surface activation and physical cleaning power through foaming when added to water.

[0004] Furthermore, in order to impart a bleaching effect and improve cleaning and deodorizing power, bleaching agents are generally blended into oral instrument cleaners. For example, Patent Document 1 proposes a denture cleaner containing an oxygen-based bleaching agent. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2005-272365 Summary of the Invention [Problem to be solved by the invention]

[0006] However, formulation technologies that incorporate surfactants and foaming agents (carbonate compounds and acids) or bleaching agents into oral instrument cleansers have limitations in terms of improving the deodorizing power of the cleansers. Furthermore, from the perspective of expanding the variety of oral instrument cleansers, there has been a demand for the development of new formulation technologies to improve the deodorizing power of oral instrument cleansers.

[0007] The object of the present disclosure is to provide an oral instrument cleanser for effervescent tablets that has excellent deodorizing effects through the use of a new formulation technology. [Means for solving the problem]

[0008] The present inventors have conducted extensive research to solve the above problems and have unexpectedly found that by blending cyclodextrin with at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and hydrogen carbonates into an oral instrument cleanser for effervescent tablets, an oral instrument cleanser with excellent deodorizing effect can be obtained. The present disclosure has been completed based on this finding and through further research.

[0009] That is, the present disclosure provides the inventions of the following aspects. Item 1. A foaming agent comprising (A) a cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates and hydrogen carbonates having an alkyl group having 8 to 20 carbon atoms, and (C) a foaming agent; Oral appliance cleansers for effervescent tablets, in which the effervescent agent (C) is a combination of carbonate and acid (however, excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried betel leaves, those containing an extract extracted from fresh or dried pomegranate fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate). Item 2. The oral instrument cleanser for effervescent tablets according to Item 1, wherein the alkyl sulfate is lauryl sulfate. Item 3. The oral instrument cleanser for effervescent tablets according to Item 1 or 2, wherein the bicarbonate is sodium bicarbonate. Item 4. The cleanser for an oral instrument worn on an effervescent tablet according to any one of Items 1 to 3, wherein the cleanser for an oral instrument worn on an effervescent tablet is a denture cleanser. Item 5. A tablet-shaped intraoral instrument cleaner obtained from the intraoral instrument cleaner for effervescent tablets according to any one of Items 1 to 4. Item 6. A method for producing a tablet-form cleanser for oral instruments, comprising subjecting a raw material mixture containing (A) cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and hydrogen carbonates, and (C) a foaming agent, wherein the foaming agent (C) is a combination of carbonate and acid, to a tableting step. Item 7. Use of a composition comprising (A) cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates, and (C) a foaming agent, wherein the foaming agent (C) is a combination of a carbonate and an acid (excluding compositions containing an extract extracted from mangosteen fruit, an extract extracted from fresh or dried betel leaves, an extract extracted from fresh or dried pomegranate fruit, and titanium dioxide, sodium carbonate, and sodium bicarbonate), for cleaning an intraoral appliance. Item 8. Use of a composition comprising (A) cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates, and (C) an effervescent agent, wherein the effervescent agent (C) is a combination of a carbonate and an acid (excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried betel leaves, those containing an extract extracted from fresh or dried pomegranate fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate) as an intraoral instrument cleanser for effervescent tablets. Item 9. Use of a composition comprising (A) cyclodextrin, (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates, and (C) a foaming agent, wherein the foaming agent (C) is a combination of a carbonate and an acid (excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried betel leaves, those containing an extract extracted from fresh or dried pomegranate fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate) as a tablet oral instrument cleanser. Item 10. A method for cleaning an intraoral instrument, comprising immersing an intraoral instrument in water containing a tablet-shaped intraoral instrument cleaner (excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried betel leaves, those containing an extract extracted from fresh or dried pomegranate fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate) comprising: (A) cyclodextrin; (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and hydrogen carbonates; and (C) a foaming agent, wherein the foaming agent (C) is a combination of carbonate and acid. Item 11. Use of a composition for the manufacture of an oral instrument cleanser for effervescent tablets, the composition comprising: (A) cyclodextrin; (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates; and (C) an effervescent agent, wherein the effervescent agent (C) is a combination of a carbonate and an acid (excluding compositions containing an extract extracted from mangosteen fruit, an extract extracted from fresh or dried betel leaves, an extract extracted from fresh or dried pomegranate fruit, and a composition containing titanium dioxide, sodium carbonate, and sodium bicarbonate). Item 12. Use of a composition for the manufacture of a tablet-form cleanser for oral instruments, the composition comprising: (A) cyclodextrin; (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates; and (C) a foaming agent, wherein the foaming agent (C) is a combination of a carbonate and an acid (excluding compositions containing an extract extracted from mangosteen fruit, an extract extracted from fresh or dried betel leaves, an extract extracted from fresh or dried pomegranate fruit, and a composition containing titanium dioxide, sodium carbonate, and sodium bicarbonate). [Effects of the Invention]

[0010] The intraoral instrument cleanser for effervescent tablets of the present disclosure exhibits an excellent deodorizing effect by containing a combination of cyclodextrin and at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates. Furthermore, the intraoral instrument cleanser for effervescent tablets of the present disclosure has an excellent deodorizing effect due to the adoption of a new formulation technology in which cyclodextrin is combined with at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates, and has the advantage of being able to expand the variety of intraoral instrument cleansers with deodorizing effects. DETAILED DESCRIPTION OF THE INVENTION

[0011] In this specification, the notation X to Y regarding a numerical range means that the range is from X to Y.

[0012] In this specification, the term "oral appliance" refers to a dental appliance that must be worn and removed in the oral cavity, such as a complete denture, a partial denture, an orthodontic appliance, a retainer, and a mouthpiece.

[0013] 1. Cleansing agent for oral instruments used in effervescent tablets The intraoral instrument cleanser for effervescent tablets of the present disclosure (hereinafter simply referred to as "oral instrument cleanser") comprises (A) cyclodextrin (hereinafter sometimes referred to as component (A)), (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and hydrogen carbonates (hereinafter sometimes referred to as component (B)), and (C) an effervescent agent (hereinafter sometimes referred to as component (C)), wherein the effervescent agent (C) is a combination of a carbonate and an acid. The intraoral instrument cleanser of the present disclosure will be described in detail below.

[0014] [Cyclodextrin] The intraoral instrument cleanser of the present disclosure contains cyclodextrin as component (A). In the intraoral instrument cleanser of the present disclosure, cyclodextrin is a component that, when incorporated into the intraoral instrument cleanser in combination with component (B), imparts excellent deodorizing power to the intraoral instrument cleanser.

[0015] The cyclodextrin is not particularly limited, and examples thereof include those having five or more glucose atoms bound thereto, specifically α-cyclodextrin having six glucose atoms bound thereto, β-cyclodextrin having seven glucose atoms bound thereto, and γ-cyclodextrin having eight glucose atoms bound thereto. The above-mentioned cyclodextrin examples may be used alone or in combination of two or more.

[0016] In one embodiment of the intraoral instrument cleanser of the present disclosure, it is preferable to use α-, β-, or γ-cyclodextrin as the cyclodextrin, from the viewpoint of further improving the deodorizing power. Also, in another embodiment of the intraoral instrument cleanser of the present disclosure, it is preferable to use any two types of cyclodextrin selected from the group consisting of α-, β-, and γ-cyclodextrin, from the viewpoint of further improving the deodorizing power. Also, in another embodiment of the intraoral instrument cleanser of the present disclosure, it is preferable to use three types of cyclodextrin, α-, β-, and γ-cyclodextrin, from the viewpoint of further improving the deodorizing power. When α-, β-, and γ-cyclodextrins are used, the weight ratios of α-, β-, and γ-cyclodextrins are not particularly limited, but from the viewpoint of further improving deodorizing power, when the total amount of α-, β-, and γ-cyclodextrins is taken as 100 parts by weight, the content of α-cyclodextrin is preferably 20 to 40 parts by weight, more preferably 25 to 35 parts by weight, the content of β-cyclodextrin is preferably 35 to 70 parts by weight, more preferably 45 to 60 parts by weight, and the content of γ-cyclodextrin is preferably 10 to 25 parts by weight, more preferably 15 to 20 parts by weight.

[0017] In the intraoral instrument cleanser of the present disclosure, the content of component (A) may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.01 to 20% by weight, and from the viewpoint of further improving the deodorizing power, the content is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight, and even more preferably 0.5 to 3% by weight.

[0018] [Alkyl sulfates and hydrogen carbonates having alkyl groups with 8 to 20 carbon atoms] The intraoral instrument cleanser of the present disclosure contains, as component (B), at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and bicarbonates. When component (B) is incorporated into the intraoral instrument cleanser in combination with cyclodextrin, it is possible to significantly improve the deodorizing power of the intraoral instrument cleanser. Furthermore, the alkyl sulfate also serves as an anionic surfactant, exerting a chemical cleaning effect. Furthermore, the bicarbonate is a constituent of a foaming agent, and also serves to generate carbon dioxide gas by reacting with acid during cleaning of intraoral instruments.

[0019] The number of carbon atoms in the alkyl group constituting the alkyl sulfate must be 8 to 20, preferably 10 to 18, and more preferably 12 to 18, from the viewpoint of significantly improving the deodorizing power of the oral instrument cleanser. The alkyl group constituting the alkyl sulfate may be either linear or branched, but is preferably linear. Examples of salts constituting the alkyl sulfate include alkali metal salts such as sodium salts and potassium salts. The alkyl sulfates may be used singly or in combination of two or more.

[0020] Among the alkyl sulfates, lauryl sulfate is preferred, alkali metal lauryl sulfate is more preferred, and sodium lauryl sulfate is even more preferred, from the viewpoint of significantly improving the deodorizing power of the oral instrument cleanser.

[0021] In the intraoral instrument cleanser of the present disclosure, the content of the alkyl sulfate may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.01 to 20% by weight, and from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight, and even more preferably 0.5 to 3% by weight.

[0022] In the intraoral instrument cleanser of the present disclosure, the content ratio of the alkyl sulfate relative to component (A) is not particularly limited, and the content of the alkyl sulfate per 1 part by weight of component (A) is, for example, 0.1 to 15 parts by weight. From the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.3 to 10 parts by weight, more preferably 0.5 to 8 parts by weight, and even more preferably 1 to 5 parts by weight.

[0023] The hydrogen carbonate salt is not particularly limited, but examples thereof include alkali metal hydrogen carbonate salts such as sodium hydrogen carbonate and potassium hydrogen carbonate, and sodium hydrogen carbonate is preferred. The hydrogen carbonate salts may be used alone or in combination of two or more.

[0024] In the intraoral instrument cleanser of the present disclosure, the content of bicarbonate may be appropriately set within a range in which the desired deodorizing effect is obtained, for example, 0.1 to 30% by weight, and from the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.5 to 20% by weight, more preferably 1 to 18% by weight, and even more preferably 3 to 15% by weight.

[0025] In the intraoral instrument cleanser of the present disclosure, the content ratio of bicarbonate relative to component (A) is not particularly limited, and the content of bicarbonate per 1 part by weight of component (A) is, for example, 0.1 to 50 parts by weight. From the viewpoint of significantly improving the deodorizing power of the intraoral instrument cleanser, the content is preferably 0.5 to 45 parts by weight, more preferably 1 to 40 parts by weight, and even more preferably 3 to 30 parts by weight.

[0026] [Foaming agent] The intraoral instrument cleanser of the present disclosure contains a foaming agent, which is a combination of a carbonate and an acid, as component (C). By containing the foaming agent, the intraoral instrument cleanser of the present disclosure can generate carbon dioxide bubbles in the rinse water, thereby exerting physical cleansing power through the foaming action.

[0027] The carbonate is not particularly limited, and examples thereof include alkali metal salts of carbonate such as sodium carbonate and potassium carbonate. The carbonate may be used alone or in combination of two or more. The acid is not particularly limited, and examples thereof include organic acids such as citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, and salicylic acid; and inorganic acids such as phosphoric acid and sulfamic acid. The acid may be used alone or in combination of two or more.

[0028] The carbonate constituting the effervescent agent is preferably an alkali metal salt of carbonic acid, more preferably sodium carbonate, and the acid constituting the effervescent agent is preferably an organic acid, more preferably citric acid or malic acid.

[0029] In the foaming agent, the ratio of carbonate to acid is not particularly limited as long as the two can react in water to generate carbon dioxide, but the content of the acid per 100 parts by weight of carbonate is, for example, 10 to 200 parts by weight, preferably 15 to 150 parts by weight, and more preferably 20 to 100 parts by weight.

[0030] In the intraoral instrument cleanser of the present disclosure, the content of foaming agent (total amount of carbonate and acid) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intraoral instruments, but can be, for example, 10 to 75 wt %, preferably 20 to 70 wt %, and more preferably 30 to 65 wt %.

[0031] [Other ingredients] In addition to the components described above, the oral instrument cleanser of the present disclosure may contain other components as needed, to the extent that the effects of the present disclosure are not impaired.

[0032] (bleach) The intraoral instrument cleanser of the present disclosure may contain a bleaching agent, which can improve cleaning power.

[0033] The type of bleaching agent used in the intraoral instrument cleanser of the present disclosure is not particularly limited as long as it is non-toxic and physiologically acceptable, and a wide range of bleaching agents commonly used in intraoral instrument cleansers can be used.

[0034] Bleaching agents include, for example, oxygen bleaching agents such as monopersulfates, perborates, percarbonates, and persulfates.

[0035] Specific examples of monopersulfates include alkali metal salts of monopersulfate such as sodium monopersulfate and potassium monopersulfate (e.g., bis(peroxymonosulfate)-bis(sulfate)-pentapotassium), ammonium monopersulfate, and hydrates thereof. Specific examples of perborates include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of percarbonates include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of persulfates include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. The bleaching agents exemplified above may be used alone or in combination of two or more. Among the bleaching agents exemplified above, preferred are monopersulfate, perborate, and percarbonate, more preferred are alkali metal monopersulfate, alkali metal perborate, and alkali metal percarbonate, and even more preferred are potassium monopersulfate, sodium perborate, and sodium percarbonate.

[0036] In the intraoral instrument cleanser of the present disclosure, the content of the bleaching agent may be appropriately set within a range that can exert the desired bleaching effect, and may be, for example, 1 to 40% by weight, preferably 5 to 35% by weight, and more preferably 10 to 30% by weight.

[0037] (bleach activator) When the intraoral instrument cleaner of the present disclosure contains an oxygen bleaching agent, it may also contain a bleaching activator. The bleaching activator is HO2 generated from the oxygen bleaching agent in water. - It reacts with the bleaching agent to generate organic peracids with a stronger bleaching effect.

[0038] The bleach activator may be any known bleach activator without any particular limitation, and examples thereof include tetraacetylethylenediamine; alkanoyloxybenzenesulfonic acids or salts thereof having an alkanoyl group containing 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms; and alkanoyloxybenzoic acids or salts thereof having an alkanoyl group containing 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms. Examples of the salts include alkali metal salts and ammonium salts. The bleach activators exemplified above may be used alone or in combination of two or more. Of the bleach activators exemplified above, tetraacetylethylenediamine is preferred from the viewpoint of excellent efficiency in generating organic peracids.

[0039] In the intraoral instrument cleanser of the present disclosure, the content of the bleaching activator may be adjusted appropriately depending on the content of the oxygen bleach, and may be, for example, 0.01 to 5 wt %, preferably 0.1 to 3 wt %, and more preferably 0.5 to 2 wt %.

[0040] (surfactant) The intraoral instrument cleanser of the present disclosure may contain a surfactant other than the alkyl sulfate. The surfactant serves as a component that exerts a chemical cleansing effect, etc.

[0041] The type of surfactant to be incorporated into the intraoral instrument cleanser of the present disclosure is not particularly limited as long as it is usable as a component of a cleanser, and any of anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants may be used. Among these surfactants, anionic surfactants are preferred.

[0042] Examples of anionic surfactants include α-olefin sulfonates, alkylbenzene sulfonates, alkylsulfoacetates, alkanesulfonates, etc. Examples of salt forms of anionic surfactants include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, amine salts, and acid addition salts such as hydrochlorides.

[0043] In the intraoral instrument cleanser of the present disclosure, one type of surfactant may be blended alone, or two or more types of surfactants may be blended in combination.

[0044] In the cleanser for intraoral instruments of the present disclosure, the content of surfactant (including the content of the alkyl sulfate) is not particularly limited as long as it can exert a foaming effect when cleaning intraoral instruments, and may be set appropriately depending on the type of surfactant used, the cleaning power to be provided, etc., and can be, for example, 0.1 to 10 wt %, preferably 0.5 to 7 wt %, and more preferably 1 to 5 wt % in terms of the total amount of surfactant.

[0045] (sugar alcohol) The oral instrument cleanser of the present disclosure may contain a sugar alcohol, which is a component that functions as a binder.

[0046] The type of sugar alcohol is not particularly limited, and examples thereof include sorbitol, mannitol, xylitol, erythritol, etc. The sugar alcohols listed above may be used alone or in combination of two or more. Among the sugar alcohols listed above, sorbitol is preferred.

[0047] In the intraoral instrument cleanser of the present disclosure, the sugar alcohol content is, for example, 1 to 30 wt %, preferably 3 to 20 wt %, more preferably 4 to 15 wt %, based on the total amount of sugar alcohol.

[0048] (Polyalkylene glycol) The oral instrument cleanser of the present disclosure may contain polyalkylene glycol, which is a component that functions as a binder.

[0049] Specific examples of polyalkylene glycols include polyethylene glycol, polypropylene glycol, and polybutylene glycol.

[0050] The polyalkylene glycol may be used alone or in combination of two or more. Among the polyalkylene glycols exemplified above, polyethylene glycol is preferred.

[0051] In the intraoral instrument cleanser of the present disclosure, the content of polyalkylene glycol is, for example, 0.1 to 5 wt %, preferably 0.5 to 2 wt %, and more preferably 0.5 to 1.5 wt %.

[0052] (lubricant) The oral instrument cleanser of the present disclosure may contain a lubricant to facilitate the process of molding into tablets.

[0053] The type of lubricant is not particularly limited, and examples thereof include magnesium stearate, calcium stearate, sodium stearyl fumarate, sucrose fatty acid esters, sodium lauryl sulfate, talc, light anhydrous silicic acid, and hydrous silicon dioxide.

[0054] The lubricant may be used alone or in combination of two or more. Among the lubricants exemplified above, magnesium stearate is preferred.

[0055] In the intraoral instrument cleanser of the present disclosure, the content of the lubricant is, for example, 0.01 to 1 wt %, preferably 0.015 to 0.5 wt %, and more preferably 0.02 to 0.3 wt %.

[0056] Other additives that can be blended into the intraoral instrument cleanser of the present disclosure include base materials (sodium sulfate, etc.), magnesium oxide, flavorings, colorants, deodorizers, anti-tartar agents, anti-rust agents, chelating agents, pH adjusters, enzymes (proteases, etc.), sweeteners, refreshing agents, foam stabilizers, preservatives, antibacterial agents, disinfectants, antiseptics, bulking agents, excipients, disintegrants, fluidizing agents, etc. The other components exemplified above may be blended singly or in any combination of two or more.

[0057] However, the intraoral instrument cleaners of the present disclosure exclude (1) those containing an extract extracted from mangosteen fruit, (2) those containing an extract extracted from fresh or dried betel leaves, (3) those containing an extract extracted from fresh pomegranate or its dried product, and (4) those containing a combination of titanium dioxide, sodium carbonate, and sodium bicarbonate. In other words, the intraoral instrument cleaners of the present disclosure do not contain (1) an extract extracted from mangosteen fruit, (2) those containing an extract extracted from fresh or dried betel leaves, (3) those containing an extract extracted from fresh pomegranate or its dried product, or (4) those containing a combination of titanium dioxide, sodium carbonate, and sodium bicarbonate. The intraoral instrument cleaners of the present disclosure are technically completely different from the intraoral instrument cleaners having the compositions (1) to (4) above.

[0058] Specifically, the extract extracted from the mangosteen (scientific name: Garcinia mangostana L.) fruit is obtained by immersing the mangosteen fruit in an aqueous organic solvent, evaporating the organic solvent from the resulting liquid, filtering and / or centrifuging the resulting precipitate, and washing the precipitate with a liquid containing an acid and / or a reducing agent as a darkening / deepening inhibitor.

[0059] The extract extracted from fresh or dried leaves of betel quid (also known as Kushou, scientific name: Piper Betle L., English name: Betel pepper) is specifically obtained by extracting fresh or dried betel leaves as they are, or crushing or pulverizing them, with water and / or an organic solvent, or by steam distilling them and then concentrating and / or extracting them with an organic solvent.

[0060] The extract extracted from the fresh fruit or dried product of pomegranate (also known as 'Sekiryu' or 'Sekiryu', scientific name: Punica granatum L., English name: Pomegranate) is specifically obtained by extracting the fresh fruit or dried product of pomegranate, either as is or after crushing or pulverizing, with water and / or an organic solvent.

[0061] 2. Formulation and manufacturing method of oral instrument cleaner The tablet-shaped oral instrument cleanser of the present disclosure can be obtained by tableting using the oral instrument cleanser for effervescent tablets of the present disclosure. Formulation into tablets can be carried out by a commonly employed tableting method. For example, a raw material mixture containing components (A) to (C) and other additives as needed may be subjected to a tableting step. Furthermore, prior to the tableting step, the mixture may be granulated as needed.

[0062] Furthermore, the tablet-form intraoral instrument cleansers of the present disclosure exclude (1) those containing an extract extracted from mangosteen fruit, (2) those containing an extract extracted from fresh or dried betel leaves, (3) those containing an extract extracted from fresh pomegranate or its dried product, and (4) those containing titanium dioxide, sodium carbonate, and sodium bicarbonate. In other words, the tablet-form intraoral instrument cleansers of the present disclosure do not contain (1) an extract extracted from mangosteen fruit, (2) those containing an extract extracted from fresh or dried betel leaves, (3) those containing an extract extracted from fresh pomegranate or its dried product, or (4) those containing a combination of titanium dioxide, sodium carbonate, and sodium bicarbonate. The tablet-form intraoral instrument cleansers of the present disclosure are technically completely different from the intraoral instrument cleansers having the compositions (1) to (4) above.

[0063] Furthermore, in the tablet-shaped intraoral instrument cleanser of the present disclosure, the weight per tablet is not particularly limited and may be appropriately determined based on ease of use, but it is desirable to set the weight per tablet to the amount required for one intraoral instrument cleansing. Specifically, the weight per tablet is 1 to 4 g, preferably 2 to 3 g.

[0064] 3. Uses of oral appliance cleaners The cleanser for intraoral instruments of the present disclosure is used as a cleaner for various intraoral instruments, but is particularly suitable for use as a denture cleanser.

[0065] 4. How to use the oral appliance cleaner The tablet-form intraoral instrument cleanser of the present disclosure is added to water, heated if necessary, and the intraoral instrument (preferably a denture) to be cleaned is placed in the water. The tablet-form intraoral instrument cleanser of the present disclosure dissolves and foams, thereby cleaning the intraoral instrument. Furthermore, since the tablet-form intraoral instrument cleanser of the present disclosure contains components (A) and (B), immersing the intraoral instrument in the cleaning solution can effectively reduce the odor of the intraoral instrument after cleaning.

[0066] The water used when cleaning an oral appliance using the tablet-shaped oral appliance cleanser of the present disclosure is not particularly limited, but examples include tap water, purified water, distilled water, and physiological saline.

[0067] When cleaning an oral appliance using the tablet-type oral appliance cleaner of the present disclosure, the oral appliance may be immersed in water and then the tablet-type oral appliance cleaner of the present disclosure added, or the oral appliance may be immersed in water after adding the tablet-type oral appliance cleaner of the present disclosure.

[0068] In addition, in cleaning intraoral instruments, the ratio of the tablet-form intraoral instrument cleaner of the present disclosure to water is appropriately set depending on the composition of the tablet-form intraoral instrument cleaner of the present disclosure, the degree of soiling of the intraoral instruments to be cleaned, etc., but for example, the tablet-form intraoral instrument cleaner may be typically about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight, per 100 parts by weight of water. More specifically, in one cleaning of intraoral instruments, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g, more preferably 1 to 5 g of the tablet-form intraoral instrument cleaner of the present disclosure is added to this.

[0069] The temperature during cleaning of intraoral instruments may be about room temperature. The time for immersing the intraoral instruments in the cleaning solution for intraoral instruments is usually about 5 minutes to 24 hours, preferably about 10 minutes to 12 hours, and more preferably about 30 minutes to 8 hours.

[0070] Furthermore, while cleaning the intraoral appliances, it is not necessary to agitate the water to which the intraoral appliance cleanser has been added. However, in order to more effectively remove dirt, odors, and the like from the intraoral appliances, the water may be agitated as needed, or the intraoral appliances may be scrubbed with a cleaning tool such as a brush. [Example]

[0071] The invention of the present disclosure will be explained in more detail below by showing examples, but the present disclosure is not limited to these examples.

[0072] Details of the cyclodextrins used in the following test examples and formulation examples are as follows: Cyclodextrin: a mixture of 13 parts by weight of α-cyclodextrin, 20 parts by weight of β-cyclodextrin, 7 parts by weight of γ-cyclodextrin, and 60 parts by weight of powdered sugar Sodium α-olefin sulfonate: Contains an average of 14 to 16 carbon atoms per molecule

[0073] Test Example Tablet-shaped cleansers for oral instruments were prepared with the compositions shown in Table 1. Specifically, the compositions prepared by mixing the components shown in Table 1 were tableted at 40 MPa using a 22mm diameter mold and a tableting machine (SMP-3012SK, small electric hydraulic pump, manufactured by Rikenkiki Co., Ltd.), to prepare tablets each weighing 2 g. In Table 1, the amount in the cyclodextrin column indicates the total amount of α-, β-, and γ-cyclodextrin.

[0074] The prepared intraoral instrument cleansers were subjected to a deodorizing test by the following method.

[0075] <Deodorization test A> 200 μL of a malodorous aqueous solution containing methyl mercaptan (methyl mercaptan concentration: 3000 ppm) was placed in a glass container. A cleaning solution was prepared by adding one tablet of each of the intraoral instrument cleaners prepared in Examples 1 to 6 and Comparative Examples 1 to 7 to 180 mL of water at 25°C. Then, 400 μL of each prepared cleaning solution was added to the glass container, and the opening of the glass container was sealed with paraffin film. The glass container was then left to stand at 25°C for 30 minutes. The concentration (ppm) of methyl mercaptan in the gas in the glass container was then measured using a detector tube gas measuring instrument and detector tube 71H-71 (manufactured by Gastec Corporation). The results are shown in Table 1. It is believed that the lower the concentration of methyl mercaptan in the gas in the glass container, the greater the ability of the components contained in the intraoral instrument cleaner to retain (encapsulate) methyl mercaptan.

[0076] <Deodorization test B> Resin chips (20 mm × 20 mm × 1.5 mm) of denture material were immersed in the malodorous aqueous solution used in Deodorization Test A. The resin chips removed from the malodorous aqueous solution were then immersed in a glass container containing 180 ml of water at 25°C, and one tablet of each of the intraoral instrument cleaners prepared in Examples 1 to 6 and Comparative Examples 1 to 7 was added and dissolved. The resin chips were then left to stand at 25°C for 3 hours to clean them. After cleaning, the resin chips were removed and placed in a 10-liter airbag, which was filled with 1.5 liters of odorless air per five resin chips. After standing at 25°C for 10 minutes, the gas in the airbag was subjected to a sensory evaluation of deodorizing properties. A 6-level odor intensity method was used for the sensory evaluation of deodorizing properties.

[0077] [6-level odor intensity method] The odor intensity of the gas inside the airbag was scored using a six-point odor intensity scale (0: no odor, 1: barely detectable odor, 2: weak odor that is identifiable, 3: easily detectable odor, 4: strong odor, 5: awful odor). The odor intensity was scored by eight trained sensory evaluation monitors who had passed an olfactory blindness test. The average score of the six monitors was used, excluding one who scored the highest and one who scored the lowest. The results are shown in Table 1. The lower the average odor intensity score, the better the deodorizing effect of the oral appliance cleaner.

[0078] [Table 1]

[0079] As shown in Table 1, the intraoral instrument cleansers containing both cyclodextrin and sodium lauryl sulfate (Examples 1 to 3) and the intraoral instrument cleansers containing both cyclodextrin and sodium bicarbonate (Examples 4 to 6) had significantly lower methyl mercaptan concentrations and lower average odor intensities than the intraoral instrument cleansers not containing either cyclodextrin or sodium lauryl sulfate or sodium bicarbonate (Comparative Examples 1 to 7), demonstrating significantly better deodorizing effects.

[0080] Prescription example Tablet-shaped intraoral instrument cleansers having the compositions shown in Tables 2 and 3 were prepared in the same manner as in the above-mentioned Test Example, and deodorizing tests were carried out in the same manner as in the above-mentioned Test Example. In Tables 2 and 3, the amount in the cyclodextrin column indicates the total amount of α-, β-, and γ-cyclodextrin. The results of the deodorizing tests confirmed that all of the intraoral instrument cleansers had excellent deodorizing effects.

[0081] [Table 2]

[0082] [Table 3]

Claims

1. (A) a cyclodextrin; (B) at least one selected from the group consisting of alkyl sulfates having an alkyl group of 8 to 20 carbon atoms and hydrogen carbonates; and (C) a foaming agent, An oral instrument cleanser for effervescent tablets, wherein the effervescent agent (C) is a combination of carbonate and acid (however, excluding those containing an extract extracted from mangosteen fruit, those containing an extract extracted from fresh or dried betel leaves, those containing an extract extracted from fresh or dried pomegranate fruit, and those containing titanium dioxide, sodium carbonate, and sodium bicarbonate).

2. 2. The oral instrument cleanser for effervescent tablets according to claim 1, wherein the alkyl sulfate is lauryl sulfate.

3. 2. The oral instrument cleanser for effervescent tablets according to claim 1, wherein the bicarbonate is sodium bicarbonate.

4. 2. The intraoral instrument cleanser for effervescent tablets according to claim 1, wherein the intraoral instrument cleanser is a denture cleanser.

5. A tablet-shaped cleanser for oral instruments, obtained from the cleanser for oral instruments for effervescent tablets according to any one of claims 1 to 4.

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