Bioenergetic mixed twisted filament and usage thereof

Abstract

To provide a bioenergetic mixed twisted filament, and a bioenergetic yarn, bioenergetic woven fabric, and products manufactured using the same.SOLUTION: The bioenergetic mixed twisted filament comprises a first filament and a second filament twisted with each other. The first filament includes a first polymer matrix and nanoparticles dispersed within the first polymer matrix. The nanoparticles contain one or more elements selected from the group consisting of Au, Ag, Ti, Ge, Zn, Al, Mg, Si, Cu, Ca, Fe, Ba, K, Na, Mn, Ni, Ga, and Pt, and combinations thereof. The second filament has a material different from that of the first filament.SELECTED DRAWING: None

Description

[Technical Field]

[0001] (Priority Claim) This application claims the benefit of U.S. Provisional Patent Application No. 63 / 570,958, filed March 28, 2024, which is incorporated herein by reference in its entirety.

[0002] (Technical field) The present invention relates to blended and twisted bioenergetic fibers and uses thereof, including bioenergetic yarns, bioenergetic fabrics, and articles made therefrom. [Background technology]

[0003] Bleeding is one of the immediate dangers associated with open wounds, especially in situations involving massive bleeding on the battlefield, in emergency care, or in surgery. Rapid control of bleeding can effectively prevent the injured person from experiencing hypotension, hypothermia, hemorrhagic shock, and even death. Therefore, to minimize these unfortunate events, the industry has striven to develop more effective hemostatic products.

[0004] Common hemostatic products include cotton gauze and hemostatic bandages, which can control bleeding from open wounds by manual compression and their inherent liquid absorption capacity. In recent years, polysaccharide fibers such as chitosan and alginate have been applied to the development of hemostatic products such as chitosan gauze due to their advantages: excellent biocompatibility, biodegradability, and antibacterial properties. However, current hemostatic products continue to face limitations in their hemostatic capabilities. Summary of the Invention [Means for solving the problem]

[0005] The inventors of the present invention have discovered that hemostatic products made from bioenergy blended and twisted fibers capable of emitting far-infrared rays (also referred to herein as bioenergy radiation) exhibit exceptionally good hemostatic properties. This discovery is surprising, given that far-infrared rays are generally thought to promote blood circulation, which is harmful to hemostasis. The inventors have also discovered that by further selecting polysaccharide fibers in combination with far-infrared fibers as the twisting material for the blended and twisted fibers, a wound dressing with excellent wound healing properties can be provided, effectively solving the problem of scarring after wound healing.

[0006] In view of the above, one object of the present invention is to comprising first and second fibers twisted together; the first fibers comprise a first polymer matrix and nanoparticles dispersed within the first polymer matrix, the nanoparticles comprising one or more elements selected from the group consisting of Au, Ag, Ti, Ge, Zn, Al, Mg, Si, Cu, Ca, Fe, Ba, K, Na, Mn, Ni, Ga, Pt, and combinations thereof; the second fibers have a different material than the first fibers; The present invention provides a bioenergy blended and twisted fiber.

[0007] In one embodiment of the invention, the first fibers and the second fibers independently have a fineness between 1 denier and 5 denier.

[0008] In one embodiment of the invention, the first fibers and the second fibers independently have a length of 10 mm to 50 mm.

[0009] In one embodiment of the invention, the first polymer matrix is ​​selected from the group consisting of polyester, poly(ethylene terephthalate) (PET), polyurethane (PU), polyvinyl chloride (PVC), polypropylene (PP), polyamide (PA), amino-containing polymers, silicones, and combinations thereof.

[0010] In some embodiments of the invention, the material of the second fibers is selected from the group consisting of plant fibers, animal fibers, recycled fibers, semi-synthetic fibers, synthetic fibers, and combinations thereof. In some embodiments of the invention, the material of the second fibers is a polysaccharide, and the polysaccharide is selected from chitosan, cellulose, hydroxymethylcellulose, collagen, alginate, and combinations thereof.

[0011] In one embodiment of the invention, the weight ratio of the first fibers to the second fibers is from 15:85 to 80:20.

[0012] Another object of the present invention is to provide a bioenergetic yarn comprising the above-described blended and twisted bioenergetic fibers.

[0013] Yet another object of the present invention is to provide a bioenergetic textile comprising the bioenergetic yarn described above, wherein the textile may have a knitted structure.

[0014] In one embodiment of the present invention, the bioenergetic textile further comprises metal threads.

[0015] It is yet another object of the present invention to provide a bioenergetic product made from the bioenergetic fabric described above.

[0016] In one embodiment of the present invention, the bioenergetic product is a hemostatic dressing and the material of the second fiber in the bioenergetic twisted blended fiber is cotton or a polysaccharide.

[0017] In one embodiment of the invention, the bioenergetic product is a wound dressing and the material of the second fiber in the bioenergetic twisted blended fiber is a polysaccharide.

[0018] It is yet another object of the present invention to provide a method of hemostasis comprising covering a bleeding site in a subject with a hemostatic dressing made from the bioenergetic textile described above. Examples of hemostatic dressings include, but are not limited to, hemostatic gauze and hemostatic bandages.

[0019] It is yet another object of the present invention to provide a method for promoting wound healing, preventing scar formation, and / or reducing scarring, comprising covering an injured area in a subject with a wound dressing made from the bioenergetic textile described above. Examples of wound dressings may be in the form of band-aids, gauze, acne patches, or wound closure strips.

[0020] To make the above-mentioned objectives, technical features and advantages of the present invention more apparent, the present invention is described in detail below with reference to several embodiments. [Brief explanation of the drawings]

[0021] [Figure 1A] Figures 1A and 1B show scanning electron microscope (SEM) images of Au nanoparticles with an SP2 core-shell structure (Figure 1A: 2000x magnification, Figure 1B: 10,000x magnification). For observation, the Au nanoparticles were spin-coated onto a glass slide. [Figure 1B] See legend to Figure 1A. [Figure 2A] Figures 2A to 2D show SEM images of Au nanoparticles with an SP2 core-shell structure (Figure 2A: 9500x magnification, Figure 2B: 17000x magnification, Figure 2C: 18000x magnification, Figure 2D: 55000x magnification). For observation, the Au nanoparticles were applied to a glass slide by drop coating. [Figure 2B] See legend to Figure 2A. [Figure 2C] See legend to Figure 2A. [Figure 2D] See legend to Figure 2A. [Figure 3A]Figures 3A to 3D are SEM photographs of the first fiber containing Au nanoparticles (Figure 3A: 60x magnification, Figure 3B: 600x magnification, Figure 3C: 2500x magnification, Figure 3D: 50000x magnification). The arrows in Figures 3A and 3C indicate the Au nanoparticles. [Figure 3B] See legend to Figure 3A. [Figure 3C] See legend to Figure 3A. [Figure 3D] See legend to Figure 3A. [Figure 4] FIG. 4 is a photograph of a first fiber containing Au nanoparticles, having a fineness of 1.5 denier and a length of 38 mm. [Figure 5A] 5A to 5C are photographs of one embodiment of a bioenergetic yarn of the present invention made from a blended and twisted bioenergetic fiber produced by intertwisting a first fiber containing Au nanoparticles with a second fiber, chitosan fiber. [Figure 5B] See legend to Figure 5A. [Figure 5C] See legend to Figure 5A. [Figure 6A] FIG. 6A is an x-ray image of one embodiment of a bioenergetic fabric of the present invention comprising nine stainless steel yarns. [Figure 6B] 6B through 6D are x-ray photographs of one embodiment of a bioenergetic textile of the present invention comprising three (FIG. 6B), five (FIG. 6C), and eight (FIG. 6D) stainless steel yarns. [Figure 6C] See legend to Figure 6B. [Figure 6D] See legend to Figure 6B. [Figure 7] FIG. 7 is a photograph of one embodiment of a bioenergetic product of the present invention that is a hemostatic dressing. DETAILED DESCRIPTION OF THE INVENTION

[0022] The following paragraphs describe in detail some embodiments of the present invention, however, the present invention may be embodied in various embodiments and is not limited to the specific embodiments described herein.

[0023] Unless otherwise specified herein, the singular terms "a," "the," and "the" in the specification and claims encompass both the singular and the plural.

[0024] Numerical ranges recited herein (e.g., 5 to 100) encompass every rational number within the specified range, and any subrange defined by any two rational numbers within that range. Thus, the numerical ranges recited herein encompass every and every interval between any two numerical values ​​between the recited minimum and maximum values.

[0025] Unless otherwise specified, terms such as "first," "second," etc. used in the specification and claims are used only to distinguish between different elements or components and should not be construed as having any particular meaning or intent to limit the order of elements to any particular order.

[0026] (1. Bioenergy Blended Twisted Fiber) The twisted, blended bioenergetic fibers of the present invention comprise or consist essentially of a first fiber and a second fiber.

[0027] The fineness of the first fiber and the second fiber can independently range from 1 denier to 5 denier. For example, the fineness of the first fiber and the second fiber can independently be 1 denier, 1.5 denier, 2 denier, 2.5 denier, 3 denier, 3.5 denier, 4 denier, 4.5 denier, or 5 denier, or can be within a range between any two of the values ​​recited herein. In a preferred embodiment of the present invention, the fineness of the first fiber and the second fiber independently ranges from 1.5 denier to 3 denier. For example, the first fiber and the second fiber can have a fineness of 1.5 denier.

[0028] The first and second fibers are preferably short fibers. Specifically, the first and second fibers can independently have lengths ranging from 10 mm to 50 mm. For example, the lengths of the first and second fibers can independently be 10 mm, 12 mm, 15 mm, 18 mm, 20 mm, 23 mm, 25 mm, 27 mm, 30 mm, 32 mm, 35 mm, 38 mm, 40 mm, 43 mm, 45 mm, 47 mm, or 50 mm, or can be within a range between any two of the values ​​recited herein. In a preferred embodiment of the present invention, the first and second fibers independently have lengths ranging from 25 mm to 40 mm, such as a length of 38 mm. Without wishing to be bound by any theory, it is believed that lengths of the first and second fibers within a specific range can achieve optimal twisting effects.

[0029] In the twisted and blended bioenergetic fibers of the present invention, the first and second fibers can be mixed and twisted in any ratio as needed without any particular limitations. For example, the weight ratio of the first fiber to the second fiber can be in the range of 1:99 to 99:1, preferably 15:85 to 80:20. For example, the weight ratio of the first fiber to the second fiber can be 5:95, 10:90, 15:85, 20:80, 25:75, 30:70, 35:65, 40:60, 45:55, 50:50, 55:45, 60:40, 65:35, 70:30, 75:25, 80:20, 85:15, 90:10, or 95:5, or within a range between any two of the values ​​listed herein. For example, the weight ratio of the first fiber to the second fiber can be 1:4. Due to the above-mentioned preferred ranges, the twisted and blended bioenergetic fibers of the present invention provide enhanced inventive efficacy. Specifically, hemostatic products made from these twisted and blended bioenergetic fibers achieve excellent hemostatic performance, and wound dressings made from a combination of these twisted and blended bioenergetic fibers and polysaccharide fibers can effectively promote wound healing and significantly improve scar-related problems.

[0030] (1.1 First Fiber) The twisted and blended bioenergetic fibers of the present invention may include one or more first fibers. The first fibers may comprise, consist essentially of, or consist of a first polymer matrix and nanoparticles dispersed within the first polymer matrix. The nanoparticles may include one or more elements selected from the group consisting of Au, Ag, Ti, Ge, Zn, Al, Mg, Si, Cu, Ca, Fe, Ba, K, Na, Mn, Ni, Ga, Pt, or combinations thereof. Preferably, the nanoparticles include at least one of Au and Ti.

[0031] The nanoparticles used in the present invention can be prepared by gas condensation, liquid-phase reduction, and mechanical alloying. Examples of liquid-phase reduction methods include, but are not limited to, coprecipitation, sol-gel, microemulsion, hydrothermal / solvothermal synthesis, template synthesis, and biomimetic synthesis. In some embodiments of the present invention, the nanoparticles are prepared by the sol-gel method and therefore have a core-shell structure. For example, nanoparticles with a core-shell structure can be prepared as follows: First, a metal precursor containing the desired element and deionized water are placed in a conical flask under continuous stirring, the mixture is heated to boiling, and an aqueous sodium citrate solution is added dropwise to the conical flask while boiling. Next, the mixture in the conical flask is boiled for 15 to 25 minutes and allowed to cool to room temperature. Next, a polyvinylpyrrolidone (PVP) solution is added to the conical flask, and the mixture is heated again to 60 to 80°C under continuous stirring and maintained for 20 to 40 minutes to obtain a solution containing PVP-coated metal nanocores. Sodium citrate and silicon-containing materials are then added to the PVP-coated metal nanocore-containing solution, and the pH of the solution is adjusted to 5 to 7 with sodium bicarbonate to react to obtain the desired nanoparticles. In a specific embodiment of the present invention, Au nanoparticles with a core-shell structure are used.

[0032] In certain embodiments of the present invention, examples of metal precursors include, but are not limited to, tetrachloroauric acid (HAuCl), titanium tetrachloride (TiCl), titanium tetraisopropanolate, tetrabutyl titanate, chloroplatinic acid, platinum(II) acetylacetonate, silver nitrate, zinc chloride, zinc nitrate, etc. Examples of silicon-containing materials include, but are not limited to, silanes, siloxanes, silyl ethers, silanols, silanol salts, silyl chlorides, and silazoles. Examples of silanes include, but are not limited to, methylsilane, methyltrimethoxysilane, methyltriethoxysilane, propyltrimethoxysilane, isobutyltrimethoxysilane, isobutyltriethoxysilane, n-octyltriethoxysilane, vinyltrimethoxysilane, vinyltriethoxysilane, dimethyldimethoxysilane, tetramethoxysilane, tetraethoxysilane (TEOS), ethyltriacetoxysilane, cyclohexylmethyldimethoxysilane, and dicyclopentyldimethoxysilane. Examples of siloxanes include, but are not limited to, polydimethylsiloxane, polymethylhydrosiloxane (PMHS), polydiethylsiloxane, polymethyl(3-glycidyloxypropyl)siloxane (PMGS), hexamethyldisiloxane, hexamethylcyclotrisiloxane, octamethyltrisiloxane, octamethylcyclotetrasiloxane, and decamethyltetrasiloxane. Examples of silyl ethers include, but are not limited to, trimethylsilyl ether, tert-butyldimethylsilyl ether, and triisopropylsilyl ether. Examples of silanols include, but are not limited to, trimethylsilanol, triethylsilanol, and tri-tert-butylsilanol. In certain embodiments of the present invention, the silicon-containing material is TEOS.

[0033] In some embodiments of the present invention, the first polymer matrix used in the first fiber may be selected from the group consisting of polyester, PU, ​​PVC, PP, PA, amino-containing polymer, silicone, and combinations thereof. In preferred embodiments of the present invention, the first matrix may be a polyester such as poly(butylene terephthalate) (PBT), poly(ethylene terephthalate) (PET), or combinations thereof.

[0034] The first fibers can be prepared using conventional methods, including full granulation, masterbatch, and injection molding. In the following examples, the first fibers were obtained using the masterbatch method, which involves blending a nanoparticle-containing bioenergetic masterbatch with a nanoparticle-free polymer matrix masterbatch in a specific ratio, followed by extrusion and screw spinning.

[0035] (1.2 Secondary Fiber) The twisted and blended bioenergetic fibers of the present invention may include one or more second fibers, the material of which is different from the material of the first fiber. By combining fibers made from different materials, the twisted and blended bioenergetic fibers of the present invention may provide excellent composite effects.

[0036] The material of the second fiber can be plant fiber, animal fiber, regenerated fiber, semi-synthetic fiber, synthetic fiber, or a composite fiber containing two or more of the aforementioned types. Depending on the desired composite effect, the material of the second fiber can be selected from the group consisting of polysaccharides, cotton, rayon, silk, heparin, polyester, linen, wool, polyurethane, polyamide (e.g., nylon), polypropylene, and combinations thereof. Examples of polysaccharides include, but are not limited to, chitosan, hydroxymethylcellulose, cellulose, collagen, alginate, and combinations thereof. In a preferred embodiment of the present invention, the material of the second fiber is a polysaccharide. Research has shown that using a polysaccharide second fiber in combination with a first fiber can have a synergistic effect, not only effectively promoting wound healing but also minimizing post-healing scarring.

[0037] (2. Bioenergetic Yarns and Fabrics) The present invention also provides a bioenergetic yarn comprising, consisting essentially of, or consisting of a plurality of the above-described bioenergetic blended and twisted fibers.

[0038] The bioenergetic yarns of the present invention exhibit excellent strength and can be used alone or in combination with other yarns to form bioenergetic textiles with a woven structure, which offers various advantages. For example, nonwoven textiles formed by bonding staple fibers in a heat press often suffer from fiber peeling, which is unacceptable in many applications, particularly in the context of hemostasis and wound dressings. In contrast, the fibers of the bioenergetic textiles of the present invention are fixed by the woven structure, eliminating the problem of fiber peeling. Furthermore, the woven structure of bioenergetic textiles provides a higher surface area than nonwoven textiles, resulting in a larger contact area for improved hemostatic efficiency. The woven structure of bioenergetic textiles also provides better breathability than nonwoven textiles, which is advantageous for wound dressing applications. In a preferred embodiment of the present invention, the bioenergetic textile has a knitted structure with superior specific surface area, breathability, and stretchability compared to other woven textile structures.

[0039] The other thread types are not particularly limited and may include metallic threads, non-metallic threads, or combinations thereof. Examples of metallic threads include, but are not limited to, composite threads of metallic and organic fibers, metallized threads, and pure metallic threads. Examples of metallic thread materials include, but are not limited to, stainless steel, copper, iron, zinc, or combinations thereof. Examples of non-metallic thread materials include, but are not limited to, cotton, linen, wool, silk, polyester, polyurethane, polyamide (e.g., nylon), polypropylene, polysaccharides, rayon, heparin, and combinations thereof. In one embodiment of the present invention, the bioenergetic fabric includes one or more stainless steel threads, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 stainless steel threads. These stainless steel threads are distinguishable by X-ray, making the bioenergetic fabric particularly suitable for use as surgical gauze.

[0040] (3. Bioenergy products obtained using bioenergy textiles) The bioenergetic textile of the present invention can be further processed into various bioenergetic products. Examples of bioenergetic products include, but are not limited to, medical dressings, bedding (e.g., blankets, mattresses, quilt covers, etc.), clothing (e.g., jackets, pants, underwear, etc.), seat cushions, eye masks, belts, braces (e.g., knee braces, elbow braces, etc.), shawls, and topical patches. Examples of medical dressings include, but are not limited to, hemostatic dressings and wound dressings. Examples of hemostatic dressings include, but are not limited to, hemostatic gauze and hemostatic bandages. Examples of wound dressings include, but are not limited to, band-aids, gauze, acne patches, or wound closure strips.

[0041] In one embodiment of the present invention, the bioenergetic fabric of the present invention is processed into a hemostatic dressing, wherein the second fiber of the bioenergetic blended twisted fiber is made from a material with high liquid absorbency, such as cotton or a polysaccharide (e.g., chitosan).

[0042] In another embodiment of the present invention, the bioenergetic fabric of the present invention is fabricated into a wound dressing, wherein the second fiber of the bioenergetic blended twisted fiber is preferably made from a polysaccharide (e.g., chitosan) to provide a synergistic effect in wound healing.

[0043] (4. Treatment) As described above, hemostatic dressings made from the bioenergetic textiles of the present invention have surprisingly excellent hemostatic properties, and wound dressings made from the bioenergetic textiles of the present invention can be used on open wounds to provide excellent wound healing effects and minimize scarring. Thus, the present invention also provides a method of hemostasis, comprising covering a bleeding area of ​​an individual with a hemostatic dressing (e.g., hemostatic gauze or hemostatic bandage) made from the bioenergetic textile described above. Furthermore, the present invention provides a method of promoting wound healing, preventing scar formation, and / or reducing scarring, comprising covering a wound area of ​​an individual with a wound dressing (e.g., a band-aid, gauze, acne patch, or wound closure strip) made from the bioenergetic textile described above.

[0044] Such individuals can be humans or non-human vertebrates, including, but not limited to, livestock (e.g., cows, horses, sheep, pigs, donkeys, and mules), poultry (e.g., chickens, ducks, and geese), companion animals (e.g., dogs, cats, rabbits, birds, hamsters, and guinea pigs), primates (e.g., monkeys, gorillas, and apes), and the like.

[0045] 5. Working Example 5.1 Example 1: Bioenergetic Fabric Production (1-1) Bioenergy blended twisted fiber For the experiments described below, the inventors of the present invention prepared nanoparticles using the following two-step process. In the first step, tetrachloroauric acid (HAuCl4) and deionized water were added to a conical flask, which was then boiled under continuous stirring. While boiling, an aqueous sodium citrate solution was added dropwise to the conical flask. After boiling for 15 to 25 minutes, the mixture in the conical flask was allowed to cool to room temperature. Polyvinylpyrrolidone (PVP) was then added to the conical flask, and the mixture was heated again to 60 to 80 °C with continuous stirring for 20 to 40 minutes, yielding a solution containing PVP-coated gold nanocores. In the second step, a shell structure formed from tetraethoxysilane (TEOS) was prepared to coat the PVP-coated gold nanocores. First, sodium citrate and TEOS were added to the solution containing the PVP-coated metal nanocores. The pH value was adjusted to 5 to 7 with sodium bicarbonate to obtain nanoparticles with an SP2 core-shell structure, in which the shell material was TEOS and the core material was a gold nanocore, as shown in Figures 1A, 1B, and 2A to 2D.

[0046] The nanoparticles, dispersant, and poly(butylene terephthalate) (PBT) were thoroughly mixed using a mixer, and the mixture was extruded using an extruder at temperatures between 230 and 295°C to produce a far-infrared masterbatch.

[0047] The far-infrared masterbatch was blended with a poly(ethylene terephthalate) (PET) masterbatch in a weight ratio of 1:20 (far-infrared masterbatch:PET masterbatch) to obtain a blend. The blend was then extruded at 265°C using an extruder. After extrusion, the blend was subjected to screw spinning to obtain the first fiber (far-infrared fiber), as shown in Figures 3A to 3D and 4. The first fiber had a fineness of 1.5 denier and a length of approximately 38 mm. The arrows in Figures 3A and 3C indicate Au nanoparticles.

[0048] The first fiber and chitosan fiber (fineness: 1.5 denier, length: 38 mm) as the second fiber were mixed and twisted in a weight ratio of 1:4 (first fiber:chitosan fiber) to obtain a bioenergy blended twisted fiber.

[0049] (1-2) Bioenergy thread The bioenergy blended twisted fiber (1-1) was spun into a bioenergy yarn as shown in Figures 5A to 5C.

[0050] (1-3) Bioenergy textiles The bioenergy yarn (1-2) and stainless steel yarn were knitted using a knitting method to produce a bioenergy fabric containing stainless steel yarn.

[0051] The stainless steel yarn-containing bioenergetic fabric was examined using an X-ray detector. The results shown in Figure 6A revealed that the stainless steel yarn-containing bioenergetic fabric contained nine stainless steel yarns. This indicates that the metal yarn-containing bioenergetic fabric of the present invention can be identified by an X-ray detector, making it particularly suitable for use as surgical gauze.

[0052] Bioenergetic textiles of the present invention containing different numbers of stainless steel yarns are shown in Figures 6B to 6D (Figure 6B: 3, Figure 6C: 5, Figure 6D: 8).

[0053] 5.2 Example 2: Hemostatic Test The bioenergy yarn (1-2) was woven using a knitting method to produce hemostatic dressings with thicknesses of 1.2 mm and 1 mm (referred to as "GB (thick)" and "GB (thin)", respectively) as shown in Figure 7, which were used for further use.

[0054] In this example, Sprague-Dawley rats (male, 8-10 weeks old, weighing 250-300 g each) were used as an animal model. These rats were randomly divided into four groups (10 rats per group) and subjected to hemostasis tests using GB (thick), GB (thin), commercially available chitosan-containing gauze (referred to as "HB"; purchased from Sigma-Aldrich, catalog number: C3646), and regular gauze (purchased from Medline, catalog number: PRM21424C).

[0055] The rats were placed on the operating table and given general anesthesia with isoflurane. After confirming that the rats were anesthetized, a 1-cm horizontal incision was made in the right femoral artery using a scalpel to simulate acute bleeding, and a timer was started. To achieve hemostasis, the injury site was treated with GB (thick), GB (thin), HB, or regular gauze. The time to hemostasis was recorded for each group of rats, and the average time to hemostasis for each group was calculated. The results are shown in Table 1. [Table 1]

[0056] As shown in Table 1, the average hemostatic time for GB (thick) and GB (thin) was only 2 and 3 minutes, respectively, which was significantly better than that of commercially available chitosan-containing gauze (HB) (about 4 minutes) and regular gauze (about 24 minutes). This result indicates that the hemostatic dressing of the present invention has excellent hemostatic effect.

[0057] The above-described embodiments are merely intended to illustrate the principles and effects of the present invention and describe its technical features, and are not intended to limit the scope of the present invention. Any modifications or arrangements that can be easily implemented by those skilled in the art without departing from the principles of the present invention fall within the scope of the claims of the present invention. Therefore, the protection scope of the present invention is defined by the claims attached hereto.

[0058] [Note] [Appendix 1] comprising first and second fibers twisted together; the first fibers comprise a first polymer matrix and nanoparticles dispersed within the first polymer matrix, the nanoparticles comprising one or more elements selected from the group consisting of Au, Ag, Ti, Ge, Zn, Al, Mg, Si, Cu, Ca, Fe, Ba, K, Na, Mn, Ni, Ga, Pt, and combinations thereof; the second fibers have a different material than the first fibers; Bioenergy blended twisted fiber.

[0059] [Appendix 2] 2. The bioenergetic blended and twisted fiber of claim 1, wherein the first fiber and the second fiber independently have a fineness of 1 denier to 5 denier.

[0060] [Appendix 3] 3. The twisted and blended bioenergetic fiber of claim 1 or 2, wherein the first and second fibers independently have a length of 10 mm to 50 mm.

[0061] [Appendix 4] 3. The twisted and blended bioenergetic fiber of claim 1 or 2, wherein the first polymer matrix is ​​selected from the group consisting of polyester, poly(ethylene terephthalate) (PET), polyurethane (PU), polyvinyl chloride (PVC), polypropylene (PP), polyamide (PA), amino-containing polymers, silicone, and combinations thereof.

[0062] [Appendix 5] 3. The bioenergy blended and twisted fiber of claim 1 or 2, wherein the material of the second fiber is selected from the group consisting of plant fibers, animal fibers, regenerated fibers, semi-synthetic fibers, synthetic fibers, and combinations thereof.

[0063] [Appendix 6] 3. The bioenergetic blended and twisted fiber of claim 1 or 2, wherein the material of the second fiber is selected from the group consisting of polysaccharides, cotton, rayon, silk, heparin, polyester, linen, wool, polyurethane, polyamide, polypropylene, and combinations thereof.

[0064] [Appendix 7] 3. The bioenergetic blended and twisted fiber of claim 1 or 2, wherein the material of the second fiber is a polysaccharide.

[0065] [Appendix 8] 8. The twisted and blended bioenergetic fiber of claim 7, wherein the polysaccharide is selected from chitosan, cellulose, collagen, alginate, and combinations thereof.

[0066] [Appendix 9] 3. The twisted and blended bioenergetic fiber of claim 1 or 2, wherein the weight ratio of the first fibers to the second fibers is from 15:85 to 80:20.

[0067] [Appendix 10] A bioenergy yarn comprising the bioenergy blended and twisted fibers described in Appendix 1 or 2.

[0068] [Appendix 11] A bioenergetic textile comprising the bioenergetic yarn of claim 10.

[0069] [Appendix 12] 12. The bioenergetic textile of claim 11, having a knitted structure.

[0070] [Appendix 13] 12. The bioenergetic textile of claim 11, further comprising metal yarns.

[0071] [Appendix 14] 12. A bioenergetic product made from the bioenergetic textile described in Appendix 11.

[0072] [Appendix 15] The bioenergy product of claim 14, wherein the bioenergy product is a hemostatic dressing and the material of the second fiber in the bioenergy blended twisted fiber is cotton or a polysaccharide.

[0073] [Appendix 16] 15. The bioenergy product of claim 14, wherein the bioenergy product is a wound dressing and the material of the second fiber in the bioenergy blended twisted fiber is a polysaccharide.

Claims

1. comprising first and second fibers twisted together; the first fibers comprise a first polymer matrix and nanoparticles dispersed within the first polymer matrix, the nanoparticles comprising one or more elements selected from the group consisting of Au, Ag, Ti, Ge, Zn, Al, Mg, Si, Cu, Ca, Fe, Ba, K, Na, Mn, Ni, Ga, Pt, and combinations thereof; the second fibers have a different material than the first fibers; Bioenergy blended twisted fiber.

2. 10. The twisted, blended bioenergetic fiber of claim 1, wherein the first and second fibers independently have a fineness between 1 denier and 5 denier.

3. 3. The twisted, blended bioenergetic fiber of claim 1, wherein the first and second fibers independently have a length of from 10 mm to 50 mm.

4. 3. The twisted and blended bioenergetic fiber of claim 1, wherein the first polymer matrix is ​​selected from the group consisting of polyester, poly(ethylene terephthalate) (PET), polyurethane (PU), polyvinyl chloride (PVC), polypropylene (PP), polyamide (PA), amino-containing polymers, silicone, and combinations thereof.

5. 3. The bioenergy blended twisted fiber of claim 1, wherein the material of the second fiber is selected from the group consisting of plant fiber, animal fiber, regenerated fiber, semi-synthetic fiber, synthetic fiber, and combinations thereof.

6. 3. The twisted and blended bioenergetic fiber of claim 1, wherein the material of the second fiber is selected from the group consisting of polysaccharides, cotton, rayon, silk, heparin, polyester, linen, wool, polyurethane, polyamide, polypropylene, and combinations thereof.

7. The bioenergetic blended twisted fiber of claim 1 or 2, wherein the material of the second fiber is a polysaccharide.

8. 8. The twisted, blended bioenergetic fiber of claim 7, wherein the polysaccharide is selected from chitosan, cellulose, collagen, alginate, and combinations thereof.

9. 3. The twisted bioenergetic blended fiber of claim 1, wherein the weight ratio of the first fibers to the second fibers is from 15:85 to 80:

20.

10. A bioenergy yarn comprising the bioenergy blended twisted fiber according to claim 1 or 2.

11. A bioenergetic textile comprising the bioenergetic yarn of claim 10.

12. The bioenergetic textile of claim 11 having a knitted structure.

13. The bioenergetic textile of claim 11 , further comprising metal yarns.

14. A bioenergetic product made from the bioenergetic textile of claim 11.

15. 15. The bioenergetic product of claim 14, wherein the bioenergetic product is a hemostatic dressing and the material of the second fiber in the bioenergetic blended twisted fiber is cotton or a polysaccharide.

16. 15. The bioenergetic product of claim 14, wherein the bioenergetic product is a wound dressing and the material of the second fiber in the bioenergetic twisted blended fiber is a polysaccharide.

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