Gamma stimulation apparatus

Abstract

To provide a gamma stimulation apparatus.SOLUTION: A gamma stimulation apparatus comprises a rectifier, a microcontroller, a first modulation operation switch (MOS), a second MOS, and first and second light sources. The microcontroller sends the first MOS a first signal having a first periodical waveform at a first operating frequency (OF1). The first MOS operates the first light source according to the first signal, producing a first light output at the OF1 frequency. The microcontroller sends to the second MOS a second signal having a second periodical waveform at a second operating frequency (OF2). The second MOS operates the second light source according to the second signal, producing a second light output at the OF2 frequency. The first and second light outputs superimpose each other to form a superimposed light having a superimposed frequency equal to OF2-OF1 and between 20 Hz and 45 Hz. The superimposed light appears flicker-free (free of flicker) to eyes of a subject.SELECTED DRAWING: Figure 4

Description

[Technical Field]

[0001] [background] This disclosure is a continuation-in-part (CIP) of U.S. patent application Ser. No. 18 / 613,079, filed March 21, 2024, which is itself a CIP of U.S. patent application Ser. No. 18 / 408,523, filed January 9, 2024. The contents of both of the above applications are incorporated herein by reference in their entirety.

[0002] [Technical field] The present disclosure relates to the field of lighting devices, and more particularly to a gamma stimulator. [Background technology]

[0003] [Description of Related Art] It has been discovered that flickering light or sound at frequencies between 35 Hz and 45 Hz, or similar frequencies, can stimulate cells in specific areas of the brain, and as a result, flickering light or sound at such frequencies has been used to treat Alzheimer's disease. However, turning a light source on and off at frequencies between 35 Hz and 45 Hz can cause visual discomfort to the subject's eyes. Various approaches have been introduced to overcome this visual discomfort under 40 Hz flickering light.

[0004] One approach in U.S. Patent Application No. 18 / 408,523 introduces the use of a controller and two light sources, with the controller operating the two light sources at two different frequencies to produce a superimposed light operating at a third frequency equal to the difference between the two frequencies. The operating frequency of the first light source is ≥ 50 Hz, and the operating frequency of the second light source is at least 30 Hz greater than the operating frequency of the first light source but not more than 65 Hz. U.S. Patent Application No. 18 / 613,079 introduces a lighting device for generating gamma visual stimuli between 20 Hz and 45 Hz by using a smart controller and a single light source, with the smart controller operating the single light source according to a superimposed waveform to produce the same gamma stimulus waveform previously produced using two light sources operating at different frequencies. The present disclosure provides further details regarding the implementation of these lighting devices for gamma stimulation. Summary of the Invention [Means for solving the problem]

[0005] In one embodiment, a gamma stimulator includes a rectifier, a microcontroller, a first modulation-operated switch (MOS), a second MOS, a first light source, and a second light source. The rectifier is configured to convert external alternating current (AC) power to internal direct current (DC) power to power the microcontroller, the first light source, and the second light source. The microcontroller is configured to send a first signal having a first periodic waveform at a first operating frequency (OF1) to the first MOS, and the first MOS (functioning like a switch) is then configured to operate the first light source in accordance with the first signal to generate a first light output at the OF1 frequency. Similarly, the microcontroller is configured to send a second signal having a second periodic waveform at a second operating frequency (OF2) greater than the OF1 frequency to the second MOS, and the second MOS (functioning like a switch) is then configured to operate the second light source in accordance with the second signal to generate a second light output at the OF2 frequency. The first light output and the second light output are superimposed on each other to form a superimposed light having a superimposition frequency equal to OF2-OF1, the superimposition frequency being between 20 Hz and 45 Hz, and the superimposed light appearing flicker-free to the eye of a subject.

[0006] Figure 1 shows a first periodic (sinusoidal) waveform at 8 Hz and a second periodic (sinusoidal) waveform at 12 Hz that generate a 4 Hz superimposed waveform (red). Figure 2 shows a first periodic (trapezoidal) waveform at 8 Hz and a second periodic (trapezoidal) waveform at 12 Hz that generate a 4 Hz superimposed waveform (red). Figure 3 shows two longer periodic trapezoidal waveforms in the on state that also generate a 4 Hz superimposed waveform (red). The trapezoidal waveforms in Figures 2 and 3 could be replaced with rectangular, square, or triangular waveforms, which would also be able to generate a corresponding 4 Hz superimposed waveform.

[0007] In some embodiments, the first periodic waveform and the second periodic waveform have the same waveform type, for example, a sinusoidal waveform, a square waveform, a rectangular waveform, a triangular waveform, or a trapezoidal waveform.

[0008] In some embodiments, the OF1 frequency is greater than 50 Hz to ensure that the baseline frequency is flicker-free to the human eye.

[0009] In some embodiments, the superimposed frequency is 40 Hz, as this frequency is known to have the best effect of stimulating specific areas of the brain to treat Alzheimer's disease. Further, in some embodiments, the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz, resulting in a superimposed frequency of 40 Hz.

[0010] In some embodiments, the first light source comprises a light-emitting diode (LED) or an organic light-emitting diode (OLED), and the second light source comprises an LED or an OLED. LEDs and OLEDs can be quickly turned on and off, making them ideal for precisely operating at the OF1 frequency and the OF2 frequency to generate a superimposed light having a waveform that is a nearly perfect superposition of the first periodic waveform and the second periodic waveform. If the first light source and the second light source had a longer ramp-up or ramp-down time when turning on and off, the superimposed light would still have a superimposed frequency equal to OF2-OF1, but its waveform would deviate slightly from the superimposed waveform of the first periodic waveform and the second periodic waveform.

[0011] It is foreseeable that one of the two microcontrollers is used to operate the first MOS and the other to operate the second MOS. Thus, in another embodiment, a gamma stimulator comprises a rectifier, a first microcontroller, a second microcontroller, a first MOS, a second MOS, a first light source, and a second light source. The rectifier is configured to convert external AC power into internal DC power to power the first microcontroller, the second microcontroller, the first light source, and the second light source. The first microcontroller is configured to send a first signal having a first periodic waveform at a first operating frequency (OF1) to the first MOS, and subsequently, the first MOS is configured to operate the first light source according to the first signal to generate a first light output at the OF1 frequency. The second microcontroller is configured to send a second signal having a second periodic waveform at a second operating frequency (OF2) greater than the OF1 frequency to the second MOS, and the second MOS is then configured to operate the second light source according to the second signal to generate a second light output at the OF2 frequency. The first light output and the second light output are superimposed on each other to form a superimposed light having a superimposed frequency equal to OF2-OF1. The superimposed frequency is between 20 Hz and 45 Hz. The superimposed light appears flicker-free to the subject's eye.

[0012] In some embodiments, the first periodic waveform and the second periodic waveform have the same waveform type, for example, a sinusoidal waveform, a square waveform, a rectangular waveform, a triangular waveform, or a trapezoidal waveform.

[0013] In some embodiments, the OF1 frequency is greater than 50 Hz to ensure that the baseline frequency is flicker-free to the human eye.

[0014] In some embodiments, the superimposed frequency is 40 Hz, as this frequency is known to have the best effect of stimulating specific areas of the brain to treat Alzheimer's disease. Further, in some embodiments, the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz, resulting in a superimposed frequency of 40 Hz.

[0015] In some embodiments, the first light source comprises an LED or an OLED and the second light source comprises an LED or an OLED.

[0016] In another embodiment, a gamma stimulator includes a rectifier, a microcontroller, a MOS, and a light source. The rectifier is configured to convert external AC power to internal DC power to power the microcontroller and the light source. The microcontroller is configured to send a signal to the MOS having a periodic waveform signal at a first frequency (F1) between 20 Hz and 45 Hz, and the MOS is then configured to operate the light source according to the signal to generate a light output at the F1 frequency. The periodic waveform is decomposable into a first periodic baseline waveform at a second frequency (F2) and a second periodic baseline waveform at a third frequency (F3), such that F1 = F3 - F2. The light output of the light source appears flicker-free to the subject's eye.

[0017] In some embodiments, the first periodic baseline waveform and the second periodic baseline waveform have the same waveform type but different frequencies.

[0018] In some embodiments, the periodic waveform has two or more peaks within a full period.

[0019] In some embodiments, the F2 frequency is greater than 50 Hz to ensure that the baseline frequency is flicker-free to the human eye.

[0020] In some embodiments, the F1 frequency is 40 Hz, as this frequency is known to have the best effect of stimulating specific areas of the brain to treat Alzheimer's disease. Further, in some embodiments, the F2 frequency is 80 Hz and the F3 frequency is 120 Hz, resulting in a superimposed frequency of 40 Hz.

[0021] In some embodiments, the light source comprises an LED or an OLED.

[0022] The microcontroller(s) and MOS(es) may be combined into a control module, while the light source(s) may be external, provided the control module is capable of powering the external light source(s) with the appropriate periodic waveform(s). Accordingly, in another aspect, a gamma stimulator includes a rectifier and a control module having a first power output port and a second power output port. The rectifier is configured to convert external AC power to internal DC power for powering the control module. The control module is configured to output a first output power having a first periodic waveform at a first operating frequency (OF1) via the first power output port. The control module is configured to output a second output power having a second periodic waveform at a second operating frequency (OF2) via the second power output port. The first power output port is configured to power a first external light source, and the second power output port is configured to power a second external light source. The light output of the first external light source and the light output of the second external light source are superimposed on each other to form a superimposed light having a superimposition frequency equal to OF2-OF1, the superimposition frequency being between 20 Hz and 45 Hz, and the superimposed light appearing flicker-free to the subject's eye.

[0023] In some embodiments, the first periodic waveform and the second periodic waveform have the same waveform type, for example, a sinusoidal waveform, a square waveform, a rectangular waveform, a triangular waveform, or a trapezoidal waveform.

[0024] In some embodiments, the OF1 frequency is greater than 50 Hz to ensure that the baseline frequency is flicker-free to the human eye.

[0025] In some embodiments, the superimposed frequency is 40 Hz, as this frequency is known to have the best effect of stimulating specific areas of the brain to treat Alzheimer's disease. Further, in some embodiments, the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz, resulting in a superimposed frequency of 40 Hz.

[0026] In yet another aspect, a gamma stimulator comprises a rectifier and a control module having a power output port. The rectifier is configured to convert external AC power to internal DC power to power the control module. The control module is configured to output an output power via the power output port having a periodic waveform signal at a first frequency (F1) between 20 Hz and 45 Hz. The periodic waveform is decomposable into a first periodic baseline waveform at a second frequency (F2) and a second periodic baseline waveform at a third frequency (F3) such that F1 = F3 - F2. The power output port is configured to supply power to an external light source. The light output of the external light source appears flicker-free to the subject's eye.

[0027] In some embodiments, the first periodic baseline waveform and the second periodic baseline waveform have the same waveform type but different frequencies.

[0028] In some embodiments, the periodic waveform has two or more peaks within a full period.

[0029] In some embodiments, the F2 frequency is greater than 50 Hz.

[0030] In some embodiments, the F1 frequency is 40 Hz. Further, in some embodiments, the F2 frequency is 80 Hz and the F3 frequency is 120 Hz. [Brief explanation of the drawings]

[0031] The accompanying drawings are included to facilitate a further understanding of the present disclosure, and are incorporated by reference into and constitute a part of this disclosure. The drawings illustrate selected embodiments of the present disclosure and, together with the detailed description below, serve to explain the principles of the present disclosure. It should be apparent that the drawings are not necessarily drawn to scale, as some components may be exaggerated relative to the size of specific implementations in order to clearly illustrate the concepts of the present disclosure.

[0032] [Figure 1] 1 schematically illustrates the superposition of two sinusoidal waveforms, the first periodic at 8 Hz and the second periodic at 12 Hz. [Figure 2] Schematically depicts the superposition of two trapezoidal waveforms, the first periodic at 8 Hz and the second periodic at 12 Hz. [Figure 3] The superposition of two further trapezoidal waveforms with longer on-state durations is depicted schematically. [Figure 4] 1 schematically illustrates an embodiment of the present disclosure using one microcontroller and two light sources. [Figure 5] 1 schematically illustrates an embodiment of the present disclosure using two microcontrollers and two light sources. [Figure 6] 1 schematically illustrates an embodiment of the present disclosure using one microcontroller and one light source. [Figure 7] 10 schematically illustrates an embodiment of the present disclosure using one control module with two power output ports. [Figure 8]10 schematically illustrates an embodiment of the present disclosure using one control module with one power output port. DETAILED DESCRIPTION OF THE INVENTION

[0033] [Overview] Various implementations of the present disclosure and related inventive concepts are described below. However, it should be appreciated that the present disclosure is not limited to any particular manner of implementation, and the various embodiments expressly described herein are primarily for illustrative purposes. For example, the various concepts described herein may be suitably implemented in a variety of gamma stimulation devices having a variety of form factors.

[0034] The gamma stimulator includes a rectifier, a microcontroller, a first modulation-operated switch (MOS), a second MOS, a first light source, and a second light source. The microcontroller sends a first signal having a first periodic waveform at a first operating frequency (OF1) to the first MOS, causing the first MOS to operate the first light source according to the first signal and generate a first light output at OF1. The microcontroller sends a second signal having a second periodic waveform at a second operating frequency (OF2) to the second MOS, causing the second MOS to operate the second light source according to the second signal and generate a second light output at OF2. The first light output and the second light output are superimposed on each other to form a superimposed light having a superimposition frequency equal to OF2-OF1, the superimposition frequency being between 20 Hz and 45 Hz. The superimposed light appears flicker-free to the subject's eyes. Various embodiments of the gamma stimulator are also presented.

[0035] [Example Implementation] 4 illustrates one embodiment 100 of a gamma stimulator of the present disclosure. The gamma stimulator 100 includes a rectifier 101, a microcontroller 102, a first MOS 103, a second MOS 104, a first light source 105, and a second light source 106. The rectifier 101 converts external AC power (120 Vac at 60 Hz) into internal DC power (V2 voltage = 24 V) to power the microcontroller 102, the first light source 105, and the second light source 106. The microcontroller 102 sends a first signal having a first periodic waveform (e.g., a square waveform) at a first operating frequency (OF1) of 80 Hz to the first MOS 103. The first MOS 103 functions like a switch to turn the first light source 105 on and off according to the first signal, generating a first light output at the OF1 frequency of 80 Hz. The microcontroller 102 sends a second signal having a second periodic waveform (e.g., a square waveform) at a second operating frequency (OF2) of 120 Hz to the second MOS 104. The second MOS 104 functions like a switch, turning the second light source 106 on and off according to the second signal to generate a second light output at the OF2 frequency of 120 Hz. The first light output and the second light output are superimposed on each other to form a superimposed light having a superimposed frequency of OF2-OF1=120 Hz-80 Hz=40 Hz. Such superimposed light appears flicker-free to the subject's eyes. The first periodic waveform and the second periodic waveform have the same waveform type, i.e., a square waveform as shown in FIG. 4, but different frequencies. The first light source 105 and the second light source 106 include an LED or an OLED.

[0036] 4, the first light source 105 and the second light source 106 are shown operating on a square waveform with a V2 voltage of 24 V. However, the first light source 105 and the second light source 106 do not have to operate on the same 24 V DC voltage as the microcontroller 102. The present disclosure requires only an internal DC power supply to power the microcontroller, the first light source, and the second light source. It is foreseeable that the internal DC power supply can be adjusted to a different voltage, i.e., a different voltage than the voltage used to power the microcontroller, to power the first light source and the second light source.

[0037] 5 illustrates another embodiment 200 of the gamma stimulator of the present disclosure. The gamma stimulator 200 includes a rectifier 201, a first microcontroller 202, a second microcontroller 203, a first MOS 204, a second MOS 205, a first light source 206, and a second light source 207. The rectifier 201 converts external AC power (120 Vac at 60 Hz) into internal DC power (V2 voltage=24 V) to power the first microcontroller 202, the second microcontroller 203, the first light source 206, and the second light source 207. The first microcontroller 202 sends a first signal having a first periodic waveform (e.g., a square waveform) at a first operating frequency (OF1) of 80 Hz to the first MOS 204. The first MOS 204 functions as a switch to turn on and off the first light source 206 according to the first signal, generating a first light output with an OF1 frequency of 80 Hz. The second microcontroller 203 sends a second signal having a second periodic waveform (e.g., a square waveform) with a second operating frequency (OF2) of 120 Hz to the second MOS 205. The second MOS 205 functions as a switch to turn on and off the second light source 207 according to the second signal, generating a second light output with an OF2 frequency of 120 Hz. The first light output and the second light output are superimposed on each other to form a superimposed light with a superimposed frequency of OF2-OF1=120 Hz-80 Hz=40 Hz. This superimposed light appears flicker-free to the subject's eyes. The first periodic waveform and the second periodic waveform have the same waveform type, i.e., a square waveform as shown in FIG. 5, but different frequencies. The first light source 206 and the second light source 207 include an LED or an OLED.

[0038] 5, the first light source 206 and the second light source 207 are shown operating on a square waveform with a V2 voltage of 24 V. However, the first light source 206 and the second light source 207 do not have to operate on the same 24 V DC voltage as the first microcontroller 202 and the second microcontroller 203. The present disclosure requires only an internal DC power supply to power the first microcontroller, the second microcontroller, the first light source, and the second light source. It is foreseeable that the internal DC power supply can be adjusted to a different voltage, i.e., a voltage different from the voltage used to power the first microcontroller and the second microcontroller, to power the first light source and the second light source.

[0039] 6 illustrates another embodiment 300 of a gamma stimulation device of the present disclosure. The gamma stimulation device 300 includes a rectifier 301, a microcontroller 302, a MOS 303, and a light source 304. The rectifier 301 is configured to convert external AC power into internal DC power (V2 voltage=24 V) to power the microcontroller 302 and the light source 304. The microcontroller 302 sends a signal having a periodic waveform signal (similar to the superimposed waveform of FIG. 1 but at 40 Hz) with a first frequency (F1) of 40 Hz to the MOS 303. The MOS 303 functions like a switch to turn the light source 304 on and off according to the signal, generating a light output with the F1 frequency of 40 Hz. The periodic waveform can be resolved into a first periodic baseline waveform (similar to the first waveform of FIG. 1 but at 80 Hz) at a second frequency (F2) of 80 Hz and a second periodic baseline waveform (similar to the second waveform of FIG. 1 but at 120 Hz) at a third frequency (F3) of 120 Hz, such that F1 = F3 - F2 = 120 Hz - 80 Hz = 40 Hz. The light output of the light source 304 appears flicker-free to the subject's eye. As can be seen in the superimposed waveform of FIG. 1, the periodic waveform has two major peaks and one minor peak within a full period. The light source 304 includes an LED or an OLED.

[0040] 6, light source 304 may or may not operate at V2 voltage=24V, i.e., the voltage used to power microcontroller 302. The present disclosure requires only internal DC power to power the microcontroller and light source. It is foreseeable that the internal DC power may be adjusted to a different voltage, i.e., a different voltage than the voltage used to power the microcontroller, to power the light source.

[0041] 1-3 to create a superimposed waveform, and then instructs MOS 303 to operate light source 304 according to the superimposed waveform. Alternatively, microcontroller 302 may locally have stored data of a periodic waveform (increased to 40 Hz) such as the red waveform in FIGS. 1-3, and instructs MOS 303 to operate light source 304 according to the stored periodic waveform, without performing any superimposition of two periodic baseline waveforms.

[0042] FIG. 7 illustrates another embodiment 400 of a gamma stimulator of the present disclosure. The gamma stimulator 400 includes a rectifier 401 and a microcontroller 402 having a first power output port 403 and a second power output 404. The rectifier 401 converts external AC power to internal DC power (V2 voltage = 24 V) to power a control module 402. The control module 402 outputs a first output power having a first periodic waveform (e.g., square waveform) at a first operating frequency (OF1) of 80 Hz via the first power output port 403. The control module 402 outputs a second output power having a second periodic waveform (e.g., square waveform) at a second operating frequency (OF2) of 120 Hz via the second power output port 404. The first power output port 403 connects to and provides power to a first external light source 405, and the second power output port 404 connects to and provides power to a second external light source 406. The light output of the first external light source 405 and the light output of the second external light source 406 are superimposed on each other to form a superimposed light having a superimposed frequency equal to OF2-OF1=120Hz-80Hz=40Hz. The superimposed light appears flicker-free to the subject's eye. The first periodic waveform and the second periodic waveform have the same waveform type, i.e., a square waveform as shown in FIG. 7, but different frequencies.

[0043] 7, the first external light source 405 and the second external light source 406 are shown operating at a square waveform with a V2 voltage of 24 V. However, the first external light source 405 and the second external light source 406 do not have to operate at the same 24 V DC voltage as the control module 402. The present disclosure requires only an internal DC power source to power the control module, a first power output port to power the first external light source, and a second power output port to power the second external light source. It is foreseeable that the voltage powering the control module may be different from the voltage of the first power output port and / or the voltage of the second power output port.

[0044] FIG. 8 illustrates another embodiment 500 of a gamma stimulator of the present disclosure. The gamma stimulator 500 includes a rectifier 501 and a microcontroller 502 having a power output port 503. The rectifier 501 converts external AC power to internal DC power (V2 voltage = 24 V) to power a control module 502. The control module 502 outputs output power via its power output port 503, having a first periodic waveform (e.g., a square waveform) at a first frequency F1 of 40 Hz. The periodic waveform is decomposable into a first periodic baseline waveform (similar to the first waveform of FIG. 1 but at 80 Hz) at a second frequency (F2) of 80 Hz and a second periodic baseline waveform (similar to the second waveform of FIG. 1 but at 120 Hz) at a third frequency (F3) of 120 Hz, such that F1 = F3 - F2 = 120 Hz - 80 Hz = 40 Hz. The power output port 503 connects to and supplies power to an external light source 504. The light output of the external light source 504 appears flicker-free to the subject's eye. As can be seen in the superimposed waveform in Figure 1, the periodic waveform has two major peaks and one minor peak within a full period.

[0045] 8, the external light source 504 may or may not operate at V2 voltage=24V, i.e., the voltage used to power the control module 502. The present disclosure requires only an internal DC power supply to power the control module and a power output port to power the external light source. It is foreseeable that the voltage powering the control module may differ from the voltage at the power output port.

[0046] The control module 502 may internally superimpose a first baseline waveform and a second baseline waveform as shown in Figures 1-3 to create a superimposed waveform, or alternatively, the control module 502 may have locally stored data of a periodic waveform (increased to 40 Hz) as shown by the red waveform in Figures 1-3 and operate the external light source 504 according to the stored periodic waveform, without performing any superimposition of two periodic baseline waveforms.

[0047] [Further and alternative implementation notes] Although the present technology has been described in language specific to particular applications, it is to be understood that the appended claims are not necessarily limited to the specific features or applications described herein. Rather, the specific features and examples are disclosed as non-limiting exemplary forms of implementing such technology.

[0048] As used in this application, the term "or" is intended to mean an inclusive "or" rather than an exclusive "or." That is, unless specified otherwise or clear from the context, "X uses A or B" is intended to mean any of the natural inclusive permutations. That is, if X uses A, X uses B, or X uses both A and B, then "X uses A or B" would be satisfied under any of the above examples. Also, the articles "a" and "an" as used in this application and the appended claims should generally be construed to mean "one or more" unless specified otherwise or clear from the context that the singular form is intended.

Claims

1. A rectifier; A microcontroller; a first modulation control switch (MOS); a second MOS; A first light source; A second light source; 1. A gamma stimulation device comprising: the rectifier is configured to convert external alternating current (AC) power into internal direct current (DC) power to power the microcontroller, the first light source, and the second light source; the microcontroller is configured to send a first signal having a first periodic waveform at a first operating frequency (OF1) to the first MOS; the first MOS is configured to operate the first light source according to the first signal to generate a first light output at the OF1 frequency; the microcontroller is configured to send a second signal having a second periodic waveform at a second operating frequency (OF2) greater than the OF1 frequency to the second MOS; the second MOS is configured to operate the second light source in accordance with the second signal to generate a second light output at the OF2 frequency; the first optical output and the second optical output are superimposed on each other to form a superimposed light having a superimposed frequency equal to OF2-OF1; the superposition frequency is between 20 Hz and 45 Hz; The apparatus, wherein the superimposed light appears flicker-free to the subject's eye.

2. The apparatus of claim 1 , wherein the first periodic waveform and the second periodic waveform have the same waveform type.

3. The apparatus of claim 1 , wherein the OF1 frequency is greater than 50 Hz.

4. 2. The apparatus of claim 1, wherein the superposition frequency is 40 Hz.

5. 5. The apparatus of claim 4, wherein the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz.

6. The device of claim 1 , wherein the first light source comprises a light emitting diode (LED) or an organic LED (OLED) and the second light source comprises another LED or OLED.

7. A rectifier; a first microcontroller; a second microcontroller; and a first modulation control switch (MOS); a second MOS; A first light source; A second light source; 1. A gamma stimulation device comprising: the rectifier is configured to convert external alternating current (AC) power into internal direct current (DC) power to power the first microcontroller, the second microcontroller, the first light source, and the second light source; the first microcontroller is configured to send a first signal having a first periodic waveform at a first operating frequency (OF1) to the first MOS; the first MOS is configured to operate the first light source according to the first signal to generate a first light output at the OF1 frequency; the second microcontroller is configured to send a second signal having a second periodic waveform at a second operating frequency (OF2) greater than the OF1 frequency to the second MOS; the second MOS is configured to operate the second light source in accordance with the second signal to generate a second light output at the OF2 frequency; the first optical output and the second optical output are superimposed on each other to form a superimposed light having a superimposed frequency equal to OF2-OF1; the superposition frequency is between 20 Hz and 45 Hz; The apparatus, wherein the superimposed light appears flicker-free to the subject's eye.

8. 8. The apparatus of claim 7, wherein the first periodic waveform and the second periodic waveform have the same waveform type.

9. 8. The apparatus of claim 7, wherein the OF1 frequency is greater than 50 Hz.

10. 8. The device of claim 7, wherein the superposition frequency is 40 Hz.

11. 11. The apparatus of claim 10, wherein the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz.

12. 8. The device of claim 7, wherein the first light source comprises a light emitting diode (LED) or an organic LED (OLED), and the second light source comprises another LED or OLED.

13. A rectifier; A microcontroller; A modulation operation switch (MOS), A light source and 1. A gamma stimulation device comprising: the rectifier is configured to convert external alternating current (AC) power into internal direct current (DC) power to power the microcontroller and the light source; the microcontroller is configured to send a signal to the MOS having a periodic waveform signal at a first frequency (F1) between 20 Hz and 45 Hz; the MOS is configured to operate the light source in accordance with the signal to generate an optical output at the F1 frequency; the periodic waveform is decomposable into a first periodic baseline waveform at a second frequency (F2) and a second periodic baseline waveform at a third frequency (F3), such that F1=F3-F2; wherein the light output of said light source appears flicker-free to the eye of a subject.

14. 14. The apparatus of claim 13, wherein the first periodic baseline waveform and the second periodic baseline waveform have the same waveform type but different frequencies.

15. 14. The apparatus of claim 13, wherein the periodic waveform has two or more peaks within a full period.

16. 14. The apparatus of claim 13, wherein the F2 frequency is greater than 50 Hz.

17. 14. The apparatus of claim 13, wherein the F1 frequency is 40 Hz.

18. 18. The apparatus of claim 17, wherein the F2 frequency is 80 Hz and the F3 frequency is 120 Hz.

19. The device of claim 13 , wherein the light source comprises a light emitting diode (LED) or an organic LED (OLED).

20. A rectifier; a control module having a first power output port and a second power output port; 1. A gamma stimulation device comprising: the rectifier is configured to convert external alternating current (AC) power into internal direct current (DC) power to power the control module; the control module is configured to output a first output power having a first periodic waveform at a first operating frequency (OF1) via the first power output port; the control module is configured to output a second output power having a second periodic waveform at a second operating frequency (OF2) via the second power output port; the first power output port is configured to provide power to a first external light source to generate a first light output; the second power output port is configured to supply power to a second external light source to generate a second light output that is superimposed on the first light output to form a superimposed light having a superimposition frequency equal to OF2-OF1; the superposition frequency is between 20 Hz and 45 Hz; The apparatus, wherein the superimposed light appears flicker-free to the subject's eye.

21. 21. The apparatus of claim 20, wherein the first periodic waveform and the second periodic waveform have the same waveform type.

22. 21. The apparatus of claim 20, wherein the OF1 frequency is greater than 50 Hz.

23. 21. The device of claim 20, wherein the superposition frequency is 40 Hz.

24. 24. The apparatus of claim 23, wherein the OF1 frequency is 80 Hz and the OF2 frequency is 120 Hz.

25. A rectifier; a control module having a power output port; 1. A gamma stimulation device comprising: the rectifier is configured to convert external alternating current (AC) power into internal direct current (DC) power to power the control module; the control module is configured to output, via the power output port, an output power having a periodic waveform signal at a first frequency (F1) between 20 Hz and 45 Hz; the periodic waveform is decomposable into a first periodic baseline waveform at a second frequency (F2) and a second periodic baseline waveform at a third frequency (F3), such that F1=F3-F2; 10. An apparatus, wherein the power output port is configured to supply power to an external light source to produce a light output of the external light source that appears flicker-free to the eye of a subject.

26. 26. The apparatus of claim 25, wherein the first periodic baseline waveform and the second periodic baseline waveform have the same waveform type but different frequencies.

27. 26. The apparatus of claim 25, wherein the periodic waveform has two or more peaks within a full period.

28. 26. The apparatus of claim 25, wherein the F2 frequency is greater than 50 Hz.

29. 26. The apparatus of claim 25, wherein the F1 frequency is 40 Hz.

30. 30. The apparatus of claim 29, wherein the F2 frequency is 80 Hz and the F3 frequency is 120 Hz.

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