Intestinal ventilation device

Abstract

To provide a device capable of continuously performing intestinal ventilation.SOLUTION: An intestinal ventilation device for administering oxygenated liquid into an intestine comprises: a propulsion section; a retaining section which retains the oxygenated liquid in a predetermined region of the intestine; an inlet section which supplies the oxygenated liquid into the intestine; an outlet section which discharges the oxygenated liquid from the intestine; a liquid circulation gas exchange section which supplies the oxygenated liquid to the inlet section, performs gas exchange on discharged liquid discharged from the outlet section and circulates the liquid; a propulsion drive section which performs propulsion drive of the propulsion section; and a retaining drive section which drives the retaining section. The propulsion section, the retaining section, the inlet section, and the outlet section constitute an intestinal insertion section inserted into the intestine.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a bowel ventilation device. [Background technology]

[0002] Currently, artificial ventilators and extracorporeal membrane oxygenation (ECMO) are used as treatments for severe respiratory failure. Because the use of these devices is highly invasive, research is underway into intestinal ventilation, a safer ventilation method that places less strain on the patient and is less invasive. Intestinal ventilation is a systemic gas exchange method in which oxygen is dissolved in a liquid with extremely high gas solubility (e.g., PFD; perfluorodecalin), and this oxygenated PFD (O2-PFD) is perfused through the large intestine, adding oxygen to the blood and removing carbon dioxide through the large intestine wall (Patent Document 1).

[0003] Patent Document 1 describes an administration device for performing gas exchange via a tube placed in the intestinal tract in intestinal ventilation. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication No. 2021 / 230317 Summary of the Invention [Problem to be solved by the invention]

[0005] However, while all of the reports on intestinal ventilation in Patent Document 1 were based on a single administration of O2-PFD, clinical application requires continuous gas exchange through continuous administration of O2-PFD. Continuous intestinal ventilation requires continuous administration and collection of O2-PFD, removal of carbon dioxide from the collected PFD, addition of oxygen, and reinfusion into the intestine. However, no continuous colonic circulation / perfusion device has yet been developed.

[0006] The present invention has been made in consideration of the above circumstances, and aims to achieve the objective of providing an intestinal ventilation device that can circulate O2-PFD over a wider area of ​​the large intestine and achieve active liquid circulation throughout the entire large intestine in order to obtain a greater gas exchange effect in intestinal ventilation.

[0007] Furthermore, in order to circulate the O2-PFD over a wider area of ​​the large intestine, it is necessary to insert the inlet tube deep into the large intestine. Although endoscopic devices are known as devices that can be inserted deep into the large intestine, existing endoscopic devices require a high level of expertise to operate, and it is expected that intestinal ventilation cannot be performed as is in emergency situations. For this reason, we investigated a system that allows the inlet tube to be automatically inserted deep into the intestine.

[0008] The present invention has been made in consideration of the above circumstances, and aims to achieve the object of providing a device that can automatically insert an inlet tube deep into the intestine in intestinal ventilation. [Means for solving the problem]

[0009] <1> An intestinal ventilation device according to one aspect of the present invention comprises: 1. An intestinal ventilation device for administering oxygenated liquid into the intestine, comprising: Promotion Department and a retention section for retaining the oxygenated liquid in a predetermined region within the intestine; an inlet portion for supplying the oxygenated liquid into the intestine; an outlet for discharging the oxygenated liquid from the intestine; a liquid circulation / gas exchange unit that supplies the oxygenated liquid to the inlet unit and circulates the discharged liquid from the outlet unit by gas exchange; a propulsion drive unit that propels and drives the propulsion unit; a placement drive unit that drives the placement unit; Equipped with the propulsion section, the retention section, the inlet section, and the outlet section constitute an intestinal insertion section to be inserted into the intestine. This solved the above problem. <2> The intestinal ventilation device of the present invention is <1> In The liquid circulation gas exchange unit includes a filter unit that filters the discharged liquid. It is possible. <3> The intestinal ventilation device of the present invention is <1> In the retention portion has a balloon portion, The placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit. It is possible. <4> The intestinal ventilation device of the present invention is <1> In the inlet portion has an inlet tube connected to a proximal end of the intestinal insertion portion, the inlet tube has a supply port for supplying the oxygenated liquid at a distal end thereof or at a position closer to a proximal end of the intestinal insertion section than the distal end thereof; It is possible. <5> The intestinal ventilation device of the present invention is <1> In The propelling portion is located at the tip of the enteral insertion portion. It is possible. <6> The intestinal ventilation device of the present invention is <1> In the retention section is disposed closer to the proximal end of the intestinal insertion section than the propulsion section. It is possible. <7> The intestinal ventilation device of the present invention is <1> In a distal end of the inlet section is disposed closer to the proximal end of the intestinal insertion section than the indwelling section; It is possible. <8> The intestinal ventilation device of the present invention is <1> In The outlet portion has an outlet for discharging the oxygenated liquid from the intestine, the outlet being disposed at a proximal end of the intestinal insertion portion. It is possible. <9> The intestinal ventilation device of the present invention is <1> In an outlet retention portion that retains the outlet portion near the anus; an outlet indwelling drive unit that drives the outlet indwelling unit; Equipped with It is possible. <10> The intestinal ventilation device of the present invention is <9> In the outlet retention portion has a balloon portion, The outlet placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit. It is possible. <11> The intestinal ventilation device of the present invention is <1> In The propulsion unit includes: The device comprises a tube assembly formed by spirally winding at least three flexible tubes that are expandable and contractible when pressure is applied thereto and sealing the ends of the tubes; the proximal ends of the tubes in the tube assembly are each connected to the propulsion drive; the propulsion drive unit is a fluid pressure source; (1) applying pressure from the propulsion drive to one of the at least three tubes; (2) depressurizing the tube and pressurizing another tube; (3) Repeat steps (1) and (2) above for all tubes in order, without overlapping, until returning to the first tube. (4) By repeating the steps (1) to (3) above, the tube assembly is deformed into a spiral shape, and the spirally transformed tube assembly rotates around the body axis, which is the center of at least three of the tubes, and the pressurized tubes of the spirally transformed tube assembly come into close contact with the inner wall of the intestine, while the entire tube assembly moves along the intestine while tracing a spiral trajectory. It is possible. <12> The intestinal ventilation device of the present invention is <11> In the propelling sections are each connected to the propelling drive section by a conduit that is less expandable than the tube at least from the proximal end of the tube assembly to the proximal end of the enteral insertion section; It is possible. <13> The intestinal ventilation device of the present invention is <1> In The intestinal insertion portion is provided with an X-ray fluoroscopy marker that can be distinguished under X-ray fluoroscopy. It is possible. <14> The intestinal ventilation device of the present invention is <1> In the liquid circulation gas exchange unit, the propulsion drive unit, and the placement drive unit are connected to a proximal end of the intestinal insertion unit. It is possible. <15> The intestinal ventilation device of the present invention is <1> In A measuring unit for measuring the pressure of the oxygenated liquid supplied into the intestine. It is possible. <16> The intestinal ventilation device of the present invention is <1> In The liquid circulation gas exchange unit includes at least a measuring unit for measuring the flow rate of the oxygenated liquid supplied to the inlet unit; a measuring unit for measuring the flow rate of the discharged liquid discharged from the outlet unit; The present invention provides one of the following: It is possible. <17> The intestinal ventilation device of the present invention is <1> In A control unit; a measuring unit that measures the pressure and flow rate of the oxygenated liquid supplied into the intestine; Equipped with the control unit controls the liquid circulation / gas exchange unit so that the pressure of the oxygenated liquid to be supplied into the intestine and the flow rate of the oxygenated liquid do not exceed predetermined values ​​based on the measurement value of the measurement unit. It is possible. <18> The intestinal ventilation device of the present invention is <17> In The measurement unit has a blood oxygen concentration sensor that measures the blood oxygen concentration of the treatment recipient, and a sensor that measures the blood carbon dioxide concentration of the treatment recipient, the control unit controls the liquid circulation / gas exchange unit based on values ​​of blood oxygen saturation and blood carbon dioxide concentration to adjust the pressure and flow rate of the oxygenated liquid to be supplied into the intestine. It is possible.

[0010] <1> An intestinal ventilation device according to one aspect of the present invention comprises: 1. An intestinal ventilation device for administering oxygenated liquid into the intestine, comprising: Promotion Department and a retention section for retaining the oxygenated liquid in a predetermined region within the intestine; an inlet portion for supplying the oxygenated liquid into the intestine; an outlet for discharging the oxygenated liquid from the intestine; a liquid circulation / gas exchange unit that supplies the oxygenated liquid to the inlet unit and circulates the discharged liquid from the outlet unit by gas exchange; a propulsion drive unit that propels and drives the propulsion unit; a placement drive unit that drives the placement unit; Equipped with the propulsion section, the retention section, the inlet section, and the outlet section constitute an intestinal insertion section to be inserted into the intestine. This solved the above problem.

[0011] In the above configuration, simply inserting the tip of the intestinal insertion section through the anus and driving the propulsion section allows the section to easily reach a predetermined position within the intestine. In this state, expanding the diameter of the retention section prevents the oxygenated liquid from leaking further into the intestine beyond a predetermined range, thereby limiting the area where intestinal ventilation is performed. Supplying oxygenated liquid through the inlet section in this state fills and stores the oxygenated liquid within the intestine (preferably the large intestine and rectum). The oxygen dissolved in the oxygenated liquid then permeates the intestinal mucosa, transferring dissolved oxygen into the blood and allowing carbon dioxide dissolved in the blood to be adsorbed by the oxygenated liquid. This allows intestinal ventilation via the intestinal mucosa.

[0012] Furthermore, by discharging oxygenated liquid from the intestine through the outlet and continuously supplying oxygenated liquid through the inlet, it is possible to generate a vigorous flow of oxygenated liquid over a wide area of ​​the intestine. By increasing the oxygen concentration of the oxygenated liquid and decreasing the carbon dioxide concentration in the liquid circulation gas exchange section, the oxygenated liquid can be regenerated and continuous gas exchange can be achieved. Therefore, continuous intestinal ventilation, which was not possible in the past, is now possible.

[0013] <2> The intestinal ventilation device of the present invention is <1> In The liquid circulation gas exchange unit includes a filter unit that filters the discharged liquid. It is possible.

[0014] In the above configuration, the drainage from the outlet is filtered by the filter, removing feces and other debris from the intestines, and the oxygenated liquid is regenerated and circulated, allowing for continuous gas exchange. Furthermore, by removing feces and the like from the intestines, preferably the large intestine and rectum, it becomes possible to improve the efficiency of gas exchange.

[0015] <3> The intestinal ventilation device of the present invention is <1> In the retention portion has a balloon portion, The placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit. It is possible.

[0016] In the above configuration, by reducing the diameter of the balloon portion, the intestinal insertion portion can be easily inserted to a predetermined position without obstructing its advance deep into the intestine. Furthermore, by expanding the diameter of the balloon portion, the oxygenated liquid can be prevented from flowing deeper into the intestine than the reservoir portion, allowing the oxygenated liquid to be stored in the intestine. The stored oxygenated liquid allows continuous gas exchange over a wide area of ​​the intestine. It is preferable to insert the balloon portion to a position close to the ileocecal junction. This allows almost the entire intestine, preferably the large intestine and rectum, to be used for gas exchange, improving the efficiency of intestinal ventilation.

[0017] <4> The intestinal ventilation device of the present invention is <1> In the inlet portion has an inlet tube connected to a proximal end of the intestinal insertion portion, the inlet tube has a supply port for supplying the oxygenated liquid at a distal end thereof or at a position closer to a proximal end of the intestinal insertion section than the distal end thereof; It is possible.

[0018] In the above configuration, the supply port is positioned deep inside the intestine, preferably deep inside the large intestine, and the balloon portion is inserted to a position close to the ileocecal region, allowing oxygenated liquid to be supplied from this position.By discharging the waste liquid from the anus through the outlet portion, almost the entire intestine, preferably the large intestine and rectum, can be used for gas exchange, thereby improving the efficiency of intestinal ventilation. In this case, the inlet tube can extend over the entire length of the intestinal insertion portion excluding the propulsion portion and the retention portion.

[0019] By locating the supply port near the tip of the inlet tube, oxygenated liquid can be supplied from as far inside the intestine as possible. Also, by locating the supply port at a peripheral position close to the tip of the inlet tube rather than at the tip, it is possible to prevent feces or the like from clogging the supply port when inserting the intestinal insertion section.

[0020] Furthermore, by providing multiple supply ports along the entire length of the inlet tube, the amount of circulating oxygenated liquid can be increased, improving the efficiency of intestinal ventilation. In particular, even if the oxygen content of oxygenated liquid supplied from a position deeper in the intestine decreases, oxygenated liquid with a higher oxygen content can be supplied from a supply port located closer to the base end, so the efficiency of intestinal ventilation does not decrease.

[0021] <5> The intestinal ventilation device of the present invention is <1> In The propelling portion is located at the tip of the enteral insertion portion. It is possible.

[0022] In the above configuration, by driving the propulsion unit, the propulsion unit can advance through the intestine and reach the back. At this time, the propulsion unit can pull the intestinal insertion unit as it advances. By setting the entry position of the propulsion unit, the region of the intestine where intestinal ventilation is to be performed can be easily set.

[0023] Furthermore, the intestinal insertion portion can be easily inserted without causing problems such as damaging the intestinal wall. This allows the intestinal insertion portion to automatically advance by driving the propulsion portion. Unlike a colonoscope, the intestinal insertion portion can be easily inserted without requiring specialized skills. Therefore, it is possible to easily set the intestinal insertion portion to a state in which intestinal ventilation is to be performed. This makes it possible to easily perform procedures involving intestinal ventilation even at emergency sites, etc.

[0024] <6> The intestinal ventilation device of the present invention is <1> In the retention section is disposed closer to the proximal end of the intestinal insertion section than the propulsion section. It is possible.

[0025] In the above configuration, the retention section does not interfere with the propulsion action of the propulsion section within the intestine. The retention section does not interfere with the action of the propulsion section pulling the intestinal insertion section. Furthermore, problems such as damage to the intestinal wall can be prevented when inserting the intestinal insertion section, making it easy to insert the intestinal insertion section. This enables the intestinal insertion section to advance automatically by driving the propulsion section. Therefore, intestinal ventilation can be easily performed without requiring specialized skills, as is the case with a colonoscope. This makes it possible to easily perform procedures involving intestinal ventilation, even at emergency sites, for example.

[0026] <7> The intestinal ventilation device of the present invention is <1> In a distal end of the inlet section is disposed closer to the proximal end of the intestinal insertion section than the indwelling section; It is possible.

[0027] In the above configuration, the expanded diameter of the retention section prevents the oxygenated liquid supplied from the supply port of the inlet from flowing deeper into the intestine than the storage section. This allows the oxygenated liquid supplied from the supply port of the inlet to be retained in the intestine on the anal side of the retention section. Expanding the diameter of the balloon section makes it possible to retain the oxygenated liquid in the intestine. The proximity of the storage section and the supply port prevents the oxygenated liquid from flowing between the supply port and the storage section, thereby preventing a decrease in the efficiency of intestinal ventilation.

[0028] <8> The intestinal ventilation device of the present invention is <1> In The outlet portion has an outlet for discharging the oxygenated liquid from the intestine, the outlet being disposed at a proximal end of the intestinal insertion portion. It is possible.

[0029] In the above configuration, oxygenated liquid can be stored in the intestine from the supply port to the discharge port of the inlet, and intestinal ventilation can be performed in the intestine from the supply port to the discharge port of the inlet. Therefore, intestinal ventilation can be performed throughout the intestine up to the anus.

[0030] <9> The intestinal ventilation device of the present invention is <1> In an outlet retention portion that retains the outlet portion near the anus; an outlet indwelling drive unit that drives the outlet indwelling unit; Equipped with It is possible.

[0031] In the above configuration, the outlet retention section can prevent oxygenated liquid from leaking from the anus. This makes it possible to maintain the treatment pressure when oxygenated liquid is stored in the intestine. It also prevents the proximal end of the intestinal insertion section from slipping out of the anus. This prevents the storage section from approaching the anus in the intestine, preventing a decrease in the area available for gas exchange in the intestine, and preventing a decrease in the efficiency of intestinal ventilation.

[0032] <10> The intestinal ventilation device of the present invention is <9> In the outlet retention portion has a balloon portion, The outlet placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit. It is possible.

[0033] In the above configuration, the balloon portion can be expanded in diameter to prevent the oxygenated liquid from leaking out of the anus. Furthermore, the balloon portion can be expanded in diameter to prevent the proximal end of the intestinal insertion portion from slipping out of the anus. These features make it possible to maintain the treatment pressure when the oxygenated liquid is stored in the intestine. Furthermore, the storage portion can be prevented from approaching the anus in the intestine, preventing a decrease in the area available for gas exchange in the intestine. Therefore, a decrease in the efficiency of intestinal ventilation can be prevented.

[0034] <11> The intestinal ventilation device of the present invention is <1> In The propulsion unit includes: The device comprises a tube assembly formed by spirally winding at least three flexible tubes that are expandable and contractible when pressure is applied thereto and sealing the ends of the tubes; the proximal ends of the tubes in the tube assembly are each connected to the propulsion drive; the propulsion drive unit is a fluid pressure source; (1) applying pressure from the propulsion drive to one of the at least three tubes; (2) depressurizing the tube and pressurizing another tube; (3) Repeat steps (1) and (2) above for all tubes in order, without overlapping, until returning to the first tube. (4) By repeating the steps (1) to (3) above, the tube assembly is deformed into a spiral shape, and the spirally transformed tube assembly rotates around the body axis, which is the center of at least three of the tubes, and the pressurized tubes of the spirally transformed tube assembly come into close contact with the inner wall of the intestine, while the entire tube assembly moves along the intestine while tracing a spiral trajectory. It is possible.

[0035] In the above configuration, multiple tubes are twisted and bonded to form a long, string-like body. This body is then placed inside a tube, and pressure is applied to each tube in turn, causing the entire body to twist in a spiral motion, propelling the body through the intestinal tract. When the multiple tubes include at least three tubes, reversing the order of pressure application reverses the direction of the spiral twisting motion and the propulsion direction. Furthermore, since the length along the body axis remains constant, passing a flexible hollow tube or cable through it can serve as a supply path for oxygenated liquid or driving fluid. Furthermore, since it is simply a bundle of flexible tubes, it is flexible and can easily pass through bent or curved parts of the intestinal tract.

[0036] <12> The intestinal ventilation device of the present invention is <11> In the propelling sections are each connected to the propelling drive section by a conduit that is less expandable than the tube at least from the proximal end of the tube assembly to the proximal end of the enteral insertion section; It is possible.

[0037] In the above-described configuration, the inlet tube and the fluid supply pipe for expanding the diameter of the balloon portion do not affect the spiral deformation drive of the tube assembly.

[0038] <13> The intestinal ventilation device of the present invention is <1> In The intestinal insertion portion is provided with an X-ray fluoroscopy marker that can be distinguished under X-ray fluoroscopy. It is possible.

[0039] In the above configuration, when the intestinal insertion portion is inserted into a curved intestine, the insertion position and insertion state of the intestinal insertion portion can be easily confirmed by X-ray irradiation. The X-ray fluoroscopy marker can be used to confirm the posture of the intestinal insertion portion, making it easy to determine the propulsion control of the propulsion portion, the setting of the diameter expansion position of the balloon portion, etc.

[0040] <14> The intestinal ventilation device of the present invention is <1> In the liquid circulation gas exchange unit, the propulsion drive unit, and the placement drive unit are connected to a proximal end of the intestinal insertion unit. It is possible.

[0041] In the above configuration, the liquid circulation / gas exchange unit, the propulsion drive unit, and the indwelling drive unit are arranged outside the body and connected to the proximal end of the intestinal insertion section, making the intestinal ventilation device easy to handle. This prevents the diameter and other dimensions of the intestinal insertion section from becoming too large, reducing the invasiveness of intestinal ventilation to the patient. This makes it possible to easily perform intestinal ventilation without the specialized skills required for colonoscopy. This makes it possible to easily perform procedures involving intestinal ventilation, even in emergency situations.

[0042] <15> The intestinal ventilation device of the present invention is <1> In A measuring unit for measuring the pressure of the oxygenated liquid supplied into the intestine. It is possible.

[0043] In the above configuration, it is possible to check whether the pressure of the oxygenated liquid supplied to the intestines is within an appropriate range, which facilitates efficient intestinal ventilation while reducing the burden on the intestinal tract.

[0044] <16> The intestinal ventilation device of the present invention is <1> In The liquid circulation gas exchange unit includes at least a measuring unit for measuring the flow rate of the oxygenated liquid supplied to the inlet unit; a measuring unit for measuring the flow rate of the discharged liquid discharged from the outlet unit; The present invention provides one of the following: It is possible.

[0045] The above configuration makes it possible to check whether the flow rate of the oxygenated liquid supplied to the intestines is within an appropriate range, thereby reducing the burden on the intestinal tract and facilitating efficient intestinal ventilation while checking whether a sufficient amount of oxygenated liquid is stored and filled in the intestines.

[0046] <17> The intestinal ventilation device of the present invention is <1> In A control unit; a measuring unit that measures the pressure and flow rate of the oxygenated liquid supplied into the intestine; Equipped with the control unit controls the liquid circulation / gas exchange unit so that the pressure of the oxygenated liquid to be supplied into the intestine and the flow rate of the oxygenated liquid do not exceed predetermined values ​​based on the measurement value of the measurement unit. It is possible.

[0047] In the above configuration, the pressure and flow rate of the oxygenated liquid in the intestine can be set within a predetermined range by controlling the control unit, and an appropriate state for intestinal ventilation can be easily maintained.

[0048] <18> The intestinal ventilation device of the present invention is <17> In The measurement unit has a blood oxygen concentration sensor that measures the blood oxygen concentration of the treatment recipient, and a sensor that measures the blood carbon dioxide concentration of the treatment recipient, the control unit controls the liquid circulation / gas exchange unit based on values ​​of blood oxygen saturation and blood carbon dioxide concentration to adjust the pressure and flow rate of the oxygenated liquid to be supplied into the intestine. It is possible.

[0049] In the above configuration, the control unit can control the pressure and flow rate of the oxygenated liquid in the intestine based on the blood oxygen concentration and blood carbon dioxide concentration, making it easy to maintain an appropriate state for intestinal ventilation.

[0050] Furthermore, in the present invention, the liquid circulation gas exchange section can be provided with a temperature control section. Furthermore, in the present invention, the liquid circulation gas exchange section can be provided with a gas-liquid separation section. Furthermore, in the present invention, the liquid circulation gas exchange section can include a pump section. Furthermore, in the present invention, the liquid circulation gas exchange section can be provided with a flow rate switching valve. [Effects of the Invention]

[0051] According to the present invention, it is possible to provide an intestinal ventilation device that can easily perform intestinal ventilation for a long period of time. [Brief explanation of the drawings]

[0052] [Figure 1] 1 is a schematic diagram showing a first embodiment of an intestinal ventilation device according to the present invention. FIG. [Figure 2] FIG. 1 is a schematic diagram showing a propelling section in a first embodiment of the intestinal ventilation device according to the present invention. [Figure 3] 1 is a perspective view showing the operation of a propelling part in a first embodiment of the intestinal ventilation device according to the present invention. FIG. [Figure 4] 10A and 10B are diagrams showing the pressurizing operation of the propelling part in the first embodiment of the intestinal ventilation device according to the present invention. [Figure 5] FIG. 2 is a view showing a pressurized state of the propelling part in the first embodiment of the intestinal ventilation device according to the present invention. [Figure 6] FIG. 1 is a schematic diagram showing an intestinal ventilation treatment state in a first embodiment of the intestinal ventilation apparatus according to the present invention. [Figure 7] 1 is an image showing an X-ray fluoroscopic state of an intestinal ventilation treatment in the first embodiment of the intestinal ventilation device according to the present invention. [Figure 8] FIG. 10 is a schematic diagram showing an inlet portion of a second embodiment of an intestinal ventilation device according to the present invention. [Figure 9] FIG. 10 is a schematic diagram showing an inlet portion of a third embodiment of the intestinal ventilation device according to the present invention. [Figure 10] FIG. 10 is a schematic diagram showing an inlet portion of a fourth embodiment of the intestinal ventilation device according to the present invention. [Figure 11]FIG. 10 is a schematic diagram showing an indwelling section in a fifth embodiment of the intestinal ventilation device according to the present invention. [Figure 12] FIG. 10 is a schematic diagram showing an indwelling section in a sixth embodiment of the intestinal ventilation device according to the present invention. [Figure 13] FIG. 10 is a schematic diagram showing a seventh embodiment of the intestinal ventilation device according to the present invention. [Figure 14] FIG. 10 is a schematic diagram showing an eighth embodiment of the intestinal ventilation device according to the present invention. [Figure 15] FIG. 13 is a schematic cross-sectional view showing the tube assembly portion of an eighth embodiment of an intestinal ventilation device according to the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0053] A first embodiment of an intestine ventilation apparatus according to the present invention will now be described with reference to the drawings. 1 is a schematic diagram showing an intestine ventilation device according to this embodiment, in which reference numeral 1 denotes the intestine ventilation device.

[0054] The intestinal ventilation device 1 of this embodiment is an administration device (apparatus) for performing intestinal ventilation as gas exchange within the intestinal tract by administering a perfluorocarbon solution containing dissolved oxygen into the intestinal tract, preferably the large intestine and rectum, to improve the subject's blood oxygen partial pressure by absorbing oxygen gas from within the intestinal tract, preferably the large intestine and rectum, and at the same time, inducing a decrease in the subject's blood carbon dioxide partial pressure by administering an oxygenated liquid into the intestinal tract, preferably the large intestine and rectum.

[0055] Furthermore, the intestinal ventilation device 1 according to this embodiment is a device that enables continuous and efficient intestinal ventilation through gas exchange by continuous administration of oxygenated liquid in clinical applications. To this end, the device enables continuous administration and collection of oxygenated liquid, removal of carbon dioxide from the collected oxygenated liquid and re-oxygenation, and reinfusion of the oxygenated liquid into the intestine to ensure smooth circulation and perfusion of the oxygenated liquid. Furthermore, the device increases the distance between the inlet and outlet points of the oxygenated liquid within the intestine, allowing circulation over a wider range of the intestine, preferably the large intestine and rectum, thereby achieving active circulation of the oxygenated liquid throughout the entire intestinal tract, preferably the large intestine and rectum. At the same time, this device can be automatically inserted deep into the intestine without damaging the intestinal wall when performing intestinal ventilation.

[0056] As shown in FIG. 1, the intestinal ventilation device 1 according to this embodiment has an intestinal insertion section 2 and an external placement section 3. The intestinal insertion section 2 is a section that is inserted from the tip to the base end into the intestine from the anus when intestinal ventilation is performed. The extracorporeal placement section 3 is connected to the intestinal insertion section 2. The extracorporeal placement section 3 is placed outside the body of the patient.

[0057] The intestinal insertion section 2 includes a propelling section 10, a retention section 20, an inlet section 30, an outlet section 40, an outlet retention section 50, and a measuring section 60. The intestinal insertion section 2 has the propelling section 10, the retention section 20, the inlet section 30, the outlet section 40, and the outlet retention section 50 arranged in a rod shape. The intestinal insertion section 2 has the propelling section 10, the retention section 20, the inlet section 30, the outlet section 40, and the outlet retention section 50 arranged in this order from the distal end to the proximal end. Here, the tip of the intestinal insertion portion 2 is the forward end in the insertion direction into the intestine. The base end of the intestinal insertion portion 2 is the rearward end in the insertion direction into the intestine. The base end of the intestinal insertion portion 2 is located near the anus when the intestinal insertion portion 2 is inserted into the intestine. When the intestinal insertion portion 2 is inserted into the intestine, the intestinal insertion portion 2 advances inside along the intestinal tract.

[0058] The intestinal insertion portion 2 is provided with X-ray fluoroscopy markers 2x that can be discerned under X-ray fluoroscopy. The X-ray fluoroscopy markers 2x are formed from a material that can be discerned under X-ray fluoroscopy, such as metal pieces. The X-ray fluoroscopy markers 2x can be metal pieces or metal spheres. A plurality of X-ray fluoroscopy markers 2x are arranged spaced apart in the longitudinal direction of the intestinal insertion portion 2. By arranging the X-ray fluoroscopy markers 2x at equal intervals in the longitudinal direction of the intestinal insertion portion 2, the position of the intestinal insertion portion 2 within the intestine can be discerned under X-ray fluoroscopy.

[0059] <Promotion Department> As shown in FIG. 1 , when the intestinal insertion section 2 is inserted into the intestine, the propulsion section 10 can automatically propel the intestine toward the back of the intestine. Driving the propulsion section 10 causes the intestinal insertion section 2 to move toward the back of the intestine. The propulsion section 10 is located at the tip of the intestinal insertion section 2. The propulsion section 10 is adjacent to the retention section 20. A plurality of X-ray fluoroscopy markers 2x can be arranged on the propulsion section 10 at intervals along its length. In particular, it is preferable that the X-ray fluoroscopy marker 2x be arranged at the tip 10a of the propulsion section 10. The propulsion unit 10 includes a pipe assembly 11 , a pipe line 12 , and a propulsion drive unit 13 .

[0060] FIG. 2 is a schematic diagram showing the propelling part of the intestinal ventilation device according to this embodiment. As shown in Figures 1 and 2, the tube assembly 11 is located at the front of the propulsion section 10 in the direction of entry into the intestine. The tube assembly 11 is in the form of a long, thin string. The tube assembly 11 has a plurality of tubes. The tube assembly 11 has a first tube 11a, a second tube 11b, and a third tube 11c. The first tube 11a, the second tube 11b, and the third tube 11c are formed by spirally winding or twisting together. The first tube 11a, the second tube 11b, and the third tube 11c all have the same diameter and length.

[0061] The first tube 11a, the second tube 11b, and the third tube 11c are made of a flexible material, such as silicone resin or silicone rubber. The first tube 11a, the second tube 11b, and the third tube 11c can be made of a material that can expand when pressurized. The first tube 11a, the second tube 11b, and the third tube 11c are spirally wound or twisted together, and then the surfaces are coated with silicone rubber to bond them together and form the tube assembly 11. The first tube 11a, the second tube 11b, and the third tube 11c have closed ends.

[0062] The first tube 11a, the second tube 11b, and the third tube 11c constitute the intestinal insertion section 2. The first tube 11a, the second tube 11b, and the third tube 11c all extend from the distal end to the proximal end of the tube assembly 11. The distal end and proximal end of the tube assembly 11 are equal to the distal end and proximal end of the propulsion section 10. The distal end of the tube assembly 11 is rounded as the distal end 10a of the propulsion section 10.

[0063] The first tube 11a is connected to the driving pressure source 13 via a first driving pressure supply line (line) 12a. The second tube 11b is connected to the driving pressure source 13 via a second driving pressure supply line (line) 12b. The third tube 11c is connected to the driving pressure source 13 via a third driving pressure supply line (line) 12c. The first tube 11a is connected to the first driving pressure supply line 12a at the proximal end of the tube assembly 11. The second tube 11b is connected to the second driving pressure supply line 12b at the proximal end of the tube assembly 11. The third tube 11c is connected to the third driving pressure supply line 12c at the proximal end of the tube assembly 11.

[0064] The first driving pressure supply pipe 12a, the second driving pressure supply pipe 12b, and the third driving pressure supply pipe 12c extend from the proximal end of the pipe assembly 11 to the proximal end of the intestinal insertion section 2. Unlike the first tube 11a, the second tube 11b, and the third tube 11c, the first driving pressure supply pipe 12a, the second driving pressure supply pipe 12b, and the third driving pressure supply pipe 12c may not be twisted together. The first driving pressure supply pipe 12a, the second driving pressure supply pipe 12b, and the third driving pressure supply pipe 12c may be made of the same flexible material as the first tube 11a, the second tube 11b, and the third tube 11c. Unlike the first tube 11a, the second tube 11b, and the third tube 11c, the first driving pressure supply pipe 12a, the second driving pressure supply pipe 12b, and the third driving pressure supply pipe 12c can be made of a material that does not expand when pressurized.

[0065] The first driving pressure supply conduit 12a is connected to the propulsion drive unit 13, which is the driving pressure source, via a first driving pressure supply outer conduit (conduit) 14a. The propulsion drive unit 13 constitutes the extracorporeal placement unit 3. The second driving pressure supply conduit 12b is connected to the propulsion drive unit 13, which is the driving pressure source, via a second driving pressure supply outer conduit (conduit) 14b. The third driving pressure supply conduit 12c is connected to the propulsion drive unit 13, which is the driving pressure source, via a third driving pressure supply outer conduit (conduit) 14c.

[0066] The first driving pressure supply outer conduit 14a, the second driving pressure supply outer conduit 14b, and the third driving pressure supply outer conduit 14c constitute the extracorporeal section 3. Although the first driving pressure supply conduit 12a and the first driving pressure supply outer conduit 14a are given different names for convenience, they can be configured as a continuous conduit. The second driving pressure supply outer conduit 14b and the third driving pressure supply outer conduit 14c can also have a similar configuration. The first tube 11a, the first driving pressure supply line 12a, and the first driving pressure outer supply line 14a are connected to each other and sealed. The second tube 11b and the third tube 11c can also be configured in a similar manner.

[0067] The first driving pressure supply pipe 14a has a first control valve 15a. The first control valve 15a is connected to the control unit 90 via a control line 16a. The control unit 90 constitutes the extracorporeal unit 3. The second driving pressure supply pipe 14b has a second control valve 15b. The second control valve 15b is connected to the control unit 90 via a control line 16b. The third driving pressure supply pipe 14c has a third control valve 15c. The third control valve 15c is connected to the control unit 90 via a control line 16c.

[0068] The first control valve 15a, the second control valve 15b, and the third control valve 15c constitute the extracorporeal unit 3. The control lines 16a to 16c constitute the extracorporeal unit 3. The first control valve 15a, the second control valve 15b, and the third control valve 15c may be, for example, two-position, three-port solenoid valves. The first control valve 15a, the second control valve 15b, and the third control valve 15c can independently connect the first tube 11a, the second tube 11b, and the third tube 11c to the driving pressure source 13 or open them to the atmosphere by energizing or deenergizing the respective solenoids using the control unit 90.

[0069] The propulsion drive unit 13 can supply fluid pressure as the driving pressure. The propulsion drive unit 13 can supply compressed air as the driving pressure. The propulsion drive unit 13 can be a compressor or service air in a hospital.

[0070] The control unit 90 can include a power supply that supplies potential to the solenoids of the first control valve 15a, the second control valve 15b, and the third control valve 165, a relay for switching the solenoid to which potential is to be supplied, a timer for timing the switching, a microcomputer for controlling the entire system, and the like.

[0071] FIG. 3 is a perspective view showing the operation of the propelling part of the intestinal ventilation device according to this embodiment. When pressure is applied to one of the three tubes of tube assembly 11, for example, first tube 11a, tube assembly 11 as a whole deforms into a spiral shape, becoming spiral 11s, as shown in Figure 3. Hereinafter, the center of this spiral 11s is defined as the spiral central axis Ah, and the centers of first, second, and third tubes 11a, 11b, and 11c are defined as the body axis Ab. When tube assembly 11 is deformed into spiral 11s inside the intestinal tract as shown in Figure 3, the pressurized tube, first tube 11a in Figure 3, becomes in close contact with the inner wall of the intestinal tract at all points along spiral central axis Ah.

[0072] In Figure 3, the first tube 11a is pressurized. When the first tube 11a is depressurized and the second tube 11b is pressurized from this state, the second tube 11b moves to the previous position of the first tube 11a. That is, the tube assembly 11 rotates counterclockwise around the body axis Ab. After the second tube 11b moves to the previous position of the first tube 11a, the second tube 11b is depressurized and the third tube 11c is pressurized, thereby achieving the aforementioned rotational motion. By sequentially repeating this pressurization and depressurization between the first, second, and third tubes 11a, 11b, and 11c, the spiral body 11s can continue its rotational motion. This rotational motion of the spiral body 11s around the body axis Ab is referred to as a spiral twisting motion. When the spiral twisting movement is performed inside a tube, the body axis Ab of the spiral body 11s is inclined relative to the inner wall of the intestinal tract, for example, the large intestine and rectum, so the spiral body 11s rolls in a direction perpendicular to the body axis Ab of the spiral body 11s, and the spiral body 11s moves along a spiral trajectory.

[0073] The propulsion unit 10 may have a central channel in addition to the three tubes of the tube assembly 11. The central channel may be, for example, a tube that supplies liquid into the intestine when the propulsion unit 10 is self-propelled. In this case, the liquid may be supplied at a position forward of the balloon unit 21 of the retention unit 20 in the propulsion direction, thereby improving lubrication when the propulsion unit 10 is propelled. The number of tubes that make up the tube assembly 11 of the propulsion section 10 may be greater than three.

[0074] <Detention Unit> As shown in FIG. 1, the indwelling section 20 has a balloon section 21, a driving pressure supply pipe line 22, and an indwelling drive section . The balloon section 21 is disposed near the base end of the propulsion section 10. The balloon section 21 is disposed at a position at the base end of the propulsion section 10 that does not hinder the expansion of the three tubes 11. The balloon section 21 and the driving pressure supply pipe 22 constitute the intestinal insertion section 2. The balloon portion 21 is connected to a driving pressure supply line 22 .

[0075] The driving pressure supply conduit 22 is connected to the balloon portion 21 at a position close to the base end of the intestinal insertion portion 2. The driving pressure supply conduit 22 extends from the balloon portion 21 to the base end of the intestinal insertion portion 2. The driving pressure supply conduit 22 is connected to the placement drive unit 23 via an outer driving pressure supply conduit 24. The outer driving pressure supply conduit 24 and the placement drive unit 23 constitute the extracorporeal placement portion 3.

[0076] The placement drive unit 23 can supply fluid pressure as the driving pressure. The placement drive unit 23 can supply compressed air as the driving pressure. The placement drive unit 23 can be a compressor or service air in a hospital. The placement drive unit 23 can also be shared with the propulsion drive unit 13. The driving pressure supply line 22 can have a control valve corresponding to the control valve 15, as with the driving pressure supply outer line 14. Alternatively, the driving pressure supply line 22 can have a switching valve. The placement drive unit 23 or the control valve is connected to the control unit 90 via a control line 26. The placement drive unit 23 or the control valve can be controlled by the control unit 90 to pressurize the balloon unit 21.

[0077] The pressurized balloon portion 21 can be expanded to increase its diameter. The size of the expanded balloon portion 21 can be set to a size that, when expanded, blocks the large intestine and prevents liquid from flowing further into the intestinal tract. FIG. 1 shows the expanded balloon portion 21. The expanded balloon portion 21 retains the oxygenated liquid in the intestine, as described below. The unpressurized balloon portion 21 has a reduced diameter. The reduced diameter balloon portion 21 may be small enough so as not to hinder the entry of the intestinal insertion portion 2 into the intestinal tract. In its reduced diameter state, the balloon portion 21 is pulled by the propulsion portion 10 and can enter the intestinal tract. Furthermore, the balloon portion 21 can be reduced in diameter to its original size or a size close to it by stopping the pressurization. The reduced diameter of the balloon portion 21 may be small enough not to hinder the removal of the intestinal insertion portion 2 from the intestinal tract.

[0078] <Inlet section> As shown in FIG. 1 , the inlet section 30 has an inlet tube 31 and an inlet conduit 32. The inlet tube 31 has a supply port 33. The supply port 33 supplies oxygenated liquid to a position closer to the base end of the intestinal insertion section 2 than the balloon section 21. In this embodiment, the supply port 33 is formed at the tip of the inlet tube 31. The inlet tube 31 extends from the supply port 33 along the intestinal insertion section 2 to the base end of the intestinal insertion section 2. The inlet tube 31 and the supply port 33 constitute the intestinal insertion section 2.

[0079] The inlet tube 31 is connected to an inlet conduit 32 at the proximal end of the intestinal insertion section 2. The inlet conduit 32 is connected to a liquid circulation / gas exchange section 70. The inlet conduit 32 and the liquid circulation / gas exchange section 70 constitute the extracorporeal section 3. The liquid circulation / gas exchange section 70 will be described later. The inlet section 30 supplies the oxygenated liquid supplied from the liquid circulation gas exchange section 70 from the supply port 33 into the intestine.

[0080] <Outlet section> As shown in FIG. 1 , the outlet section 40 has an outlet tube 41 and an outlet conduit 42. The outlet tube 41 has a discharge port 43. The discharge port 43 is formed at a position close to the proximal end of the intestinal insertion section 2. The discharge port 43 is located in the intestinal tract close to the anus during intestinal ventilation treatment. The discharge port 43 discharges oxygenated liquid in the intestine as discharge liquid. The outlet tube 41 is connected to the outlet conduit 42. The outlet conduit 42 is connected to the liquid circulation gas exchange section 70. The outlet tube 41 and the discharge port 43 constitute the intestinal insertion section 2. The outlet conduit 42 constitutes the extracorporeal placement section 3. The outlet section 40 discharges the oxygenated liquid used for gas exchange from the intestines and returns it to the liquid circulation gas exchange section 70.

[0081] <Outlet storage section> As shown in FIG. 1, the outlet placement section 50 has a balloon section 51, a driving pressure supply pipe line 52, an outlet placement drive section 53, a driving pressure supply outer pipe line 54, a flange section 55, and a stopper section 59. The stopper portion 59 forms the base end of the intestinal insertion portion 2. The stopper portion 59 is arranged at the base end of the intestinal insertion portion 2. The stopper portion 59 is placed in the anus during intestinal ventilation treatment. The stopper portion 59 is arranged both inside and outside the intestine relative to the anus during intestinal ventilation treatment. The stopper portion 59 serves as a plug during intestinal ventilation treatment. The stopper portion 59 has a columnar outer shape. A plurality of conduits 12, 22, 32, 42, etc. are arranged inside the stopper portion 59.

[0082] The stopper portion 59 has a flange portion 55 at a position outside the intestine relative to the anus. The flange portion 55 has a larger diameter than the stopper portion 59. The flange portion 55 defines the maximum insertion position of the intestinal insertion portion 2. The stopper portion 59 has the balloon portion 51 at a position that is closer to the intestine than the anus during intestinal ventilation treatment. The balloon portion 51 is connected to a driving pressure supply pipe 52. The stopper portion 59, the balloon portion 51, and the driving pressure supply pipe 52 constitute the intestinal insertion portion 2. The driving pressure supply conduit 52 extends from the balloon portion 51 to a position outside the anus of the stopper portion 59. The driving pressure supply conduit 52 is connected to the outlet placement drive unit 53 via an outer driving pressure supply conduit 54. The outer driving pressure supply conduit 54 and the outlet placement drive unit 53 constitute the extracorporeal placement unit 3.

[0083] The outlet placement drive unit 53 can supply fluid pressure as the driving pressure. The outlet placement drive unit 53 can supply compressed air as the driving pressure. The outlet placement drive unit 53 can be a compressor or hospital service air. The outlet placement drive unit 53 can also be shared with the placement drive unit 23 or the propulsion drive unit 13. The driving pressure supply line 52 can have a control valve corresponding to the control valve 15, as with the driving pressure supply line 14. Alternatively, the driving pressure supply line 52 can have a switching valve. The outlet placement drive unit 53 or the control valve is connected to the control unit 90 via a control line 56. The outlet placement drive unit 53 or the control valve can pressurize the balloon unit 51 under the control of the control unit 90.

[0084] The pressurized balloon portion 51 can be expanded to increase its diameter. The size of the expanded balloon portion 51 can be set to a size that, when expanded, blocks the anus and prevents liquid from flowing outward. FIG. 1 shows the expanded balloon portion 51. The expanded balloon portion 51 retains the oxygenated liquid in the intestine, as described below. The unpressurized balloon portion 51 has a reduced diameter. The reduced diameter of the balloon portion 51 need only be small enough not to obstruct the entry of the stopper portion 59 into the intestinal tract from the anus. In its reduced diameter state, the balloon portion 51 is pulled by the propulsion portion 10 and can enter the intestinal tract from the anus. Furthermore, the diameter of the balloon portion 51 can be reduced to its original size or a size close to it by stopping the pressure application. The reduced diameter of the balloon portion 51 needs to be small enough not to hinder the removal of the stopper portion 59 from the anus.

[0085] <Measurement part> As shown in FIG. 1 , the measuring unit 60 has a pressure sensor 61. The pressure sensor 61 is capable of measuring the pressure of the oxygenated liquid supplied into the intestine. The pressure sensor 61 is disposed at a position closer to the base end of the intestinal insertion unit 2 than the balloon unit 21 of the intestinal insertion unit 2. The pressure sensor 61 is connected to the control unit 90 via a control line 69. The pressure sensor 61 may be a fiber pressure sensor. The pressure sensor 61 is capable of outputting the measured pressure value to the control unit 90. The pressure sensor 61 constitutes the intestinal insertion unit 2.

[0086] The measuring unit 60 also has a pressure sensor 62 and a flow rate sensor 63. The pressure sensor 62 and the flow rate sensor 63 are arranged in the inlet conduit 32. The pressure sensor 62 and the flow rate sensor 63 are arranged in the immediate vicinity of where the inlet conduit 32 is connected to the intestinal insertion section 2. The pressure sensor 62 and the flow rate sensor 63 can measure the pressure and flow rate of the oxygenated liquid supplied into the intestine. The pressure sensor 62 and the flow rate sensor 63 are connected to the control unit 90 via a control line 69. The pressure sensor 62 and the flow rate sensor 63 constitute the extracorporeal section 3.

[0087] The measuring unit 60 has a flow rate sensor 64. The flow rate sensor 64 is disposed in the outlet conduit 42. The flow rate sensor 64 is disposed in the immediate vicinity of where the outlet conduit 42 is connected to the intestinal insertion section 2. The flow rate sensor 64 can measure the pressure and flow rate of the oxygenated liquid discharged from the intestine. The flow rate sensor 64 is connected to the control unit 90 via a control line 69. The flow rate sensor 64 constitutes the extracorporeal section 3. The measuring unit 60 is used to monitor the pressure in the intestine and control the flow rate. The measuring unit 60 is used to prevent excessive pressure by monitoring the flow rate and pressure of the delivered fluid.

[0088] <Liquid circulation gas exchange section> As shown in FIG. 1, the liquid circulation gas exchange unit 70 has a filter unit 71, a temperature adjustment unit (heat exchange unit) 72, a gas-liquid separation unit 73, an oxygenator unit 74, a pump 75, and a control valve 76. The liquid circulation gas exchange unit 70 supplies oxygenated liquid to the inlet unit 30 and performs gas exchange with the discharged liquid discharged from the outlet unit 40 to enable circulation. The liquid circulation gas exchange unit 70 is connected to the inlet unit 30 via the inlet pipe 32.

[0089] The liquid circulation gas exchange unit 70 is connected to the outlet unit 40 via an outlet conduit 42. The liquid circulation gas exchange unit 70 is connected to the control unit 90 via a control line 79. The liquid circulation gas exchange unit 70 constitutes the extracorporeal unit 3. The liquid circulation gas exchange section 70 may have a pressure sensor 62 and a flow rate sensor 63 between it and the inlet section 30 . The liquid circulation gas exchange unit 70 may have a flow rate sensor 64 between it and the outlet unit 40 .

[0090] The filter unit 71 is disposed at the most upstream of the liquid circulation gas exchange unit 70. The filter unit 71 removes contents such as feces from the discharged liquid discharged from the outlet unit 40, enabling the oxygenated liquid to be regenerated and circulated. The filter unit 71 can remove not only solid matter but also foreign matter such as liquid from the oxygenated liquid. The filter unit 71 may remove foreign matter by causing the discharged liquid to flow down through the filter. The filter unit 71 may remove foreign matter by pressurizing the discharged liquid. The filter unit 71 may have a reservoir for storing the filtered liquid.

[0091] The temperature adjustment unit 72 is positioned following the filter unit 71 in the direction of flow in the liquid circulation / gas exchange unit 70. The temperature adjustment unit 72 adjusts the liquid processed by the filter unit 71 to a predetermined temperature. The liquid circulation / gas exchange unit 70 adjusts the temperature of the regenerated oxygenated liquid to a preferred range for circulating and returning it to the intestine. The temperature range of the oxygenated liquid adjusted by the temperature adjustment unit 72 adjusts the temperature of the oxygenated liquid to be supplied to the intestine, taking into account the temperature decrease due to the processing time downstream of the liquid circulation / gas exchange unit 70. The temperature adjustment unit 72 may include a heat exchanger. The temperature adjustment unit 72 may also include a reservoir for storing the temperature-adjusted liquid. The temperature adjustment unit 72 can reduce the oxygen balance during intestinal ventilation. The temperature adjustment unit 72 is connected to the control unit 90 via a control line 79.

[0092] The gas-liquid separation unit 73 is disposed at a position following the temperature adjustment unit 72 in the direction of flow in the liquid circulation / gas exchange unit 70. The gas-liquid separation unit 73 separates gas from the liquid treated by the filter unit 71 and the temperature adjustment unit 72. The gas-liquid separation unit 73 is an air trap. The gas-liquid separation unit 73 separates gas, such as intestinal gas, from the liquid discharged from the outlet unit 40 if such gas is present. The gas-liquid separation unit 73 may have a reservoir for storing the liquid from which the gas and liquid have been separated. Even if gas accumulates in the intestines, the gas-liquid separation unit 73 can discharge the gas and circulate the liquid, thereby enabling sufficient intestinal ventilation.

[0093] The oxygenator 74 is disposed at a position following the gas-liquid separator 73 in the direction of flow in the liquid circulation gas exchanger 70. The oxygenator 74 is a gas exchanger. The oxygenator 74 performs gas exchange on the liquid treated by the filter 71, temperature regulator 72, and gas-liquid separator 73, enabling it to be recycled and reused. The oxygenator 74 removes carbon dioxide and adds oxygen to the oxygenated liquid circulated for use in intestinal ventilation. The oxygenator 74 removes carbon dioxide from the discharged liquid with a high carbon dioxide concentration discharged from the outlet 40 to reduce the carbon dioxide concentration. The oxygenator 74 adds carbon dioxide to the discharged liquid with a low oxygen concentration discharged from the outlet 40 to increase the oxygen concentration. The oxygenator 74 is connected to the controller 90 via a control line 79.

[0094] The configuration of the oxygenator 74 is not particularly limited as long as it is capable of performing gas exchange of the circulating oxygenated liquid. The oxygenator 74 may include a liquid storage section for gas exchange, a gas exchange section, an oxygen supply means, and a carbon dioxide removal means. The oxygenator 74 may also include a reservoir for storing the oxygenated liquid to be supplied.

[0095] The gas exchange section can be configured to add oxygen gas to the PFD by bubbling. When oxygen gas is bubbled into an oxygenated liquid when the oxygen concentration in the PFD is low, the oxygen concentration in the PFD is low. Therefore, oxygen moves into the oxygenated liquid due to the difference (balance) in the oxygen concentration in the PFD relative to the bubbled oxygen gas. The oxygen concentration in the PFD increases. At the same time, the bubbling agitates the liquid, accelerating the transfer of oxygen.

[0096] The gas exchange section may have a configuration for bubbling atmospheric air into the PFD to remove carbon dioxide from the PFD. When atmospheric air is bubbled into an oxygenated liquid with a high carbon dioxide concentration in the PFD, the carbon dioxide concentration in the air is lower than that in the PFD. Therefore, due to the difference (balance) between the carbon dioxide concentration in the PFD and that of the bubbled air, the carbon dioxide in the oxygenated liquid moves to the atmosphere. At the same time, the bubbling agitates the liquid, accelerating the movement of carbon dioxide. As the oxygenator 74, a known oxygenator can be used.

[0097] The oxygenator 74 can reduce the oxygen concentration to a level required for the oxygenated liquid circulated for intestinal ventilation and the carbon dioxide concentration to a level that allows it to be recirculated into the intestine. The oxygenator 74 sets the carbon dioxide and oxygen concentrations of the oxygenated liquid sent in the direction of flow through the liquid circulation gas exchange unit 70 to within predetermined ranges and sends the liquid downstream. The oxygenator 74 sets the carbon dioxide and oxygen concentrations of the oxygenated liquid sent in the direction of flow through the liquid circulation gas exchange unit 70 to within predetermined ranges and maintains them. The oxygenator 74 can send oxygenated liquid that can sustain intestinal ventilation in the direction of flow through the liquid circulation gas exchange unit 70 for a long period of time.

[0098] The pump 75 pressurizes the oxygenated liquid processed in the oxygenator 74 and delivers it to the inlet 30. The pump 75 can set the flow rate and pressure of the circulating oxygenated liquid so that intestinal ventilation is achieved as the oxygenated liquid is supplied from the inlet 30 to the depths of the intestine, moves through the intestine, and is discharged from the outlet 40 near the anus. The pump 75 can maintain a flow rate and pressure of the oxygenated liquid sufficient to achieve intestinal ventilation for a long period of time as the oxygenated liquid is supplied from the inlet 30 to the depths of the intestine, moves through the intestine, and is discharged from the outlet 40 near the anus. A centrifugal pump can be used as the pump 75 to prevent excessive pressure from being applied to the intestine during perfusion. The pump 75 sets the amount of liquid delivered per unit time per body weight. The pump 75 is connected to the control unit 90 via a control line 79.

[0099] The control valve 76 controls the flow rate of the oxygenated liquid supplied from the inlet 30 to the depths of the intestine. The control valve 76 is connected to the control unit 90 via a control line 79. The control valve 76 sets the amount of liquid delivered per unit time per body weight.

[0100] The control unit 90 controls the propulsion drive unit 13, the control valve 15, the placement drive unit 23, the outlet placement drive unit 53, and the liquid circulation gas exchange unit 70. The control unit 90 outputs measured values ​​from the pressure sensor 61, the pressure sensor 62, the flow rate sensor 63, and the flow rate sensor 64. The control unit 90 constitutes the extracorporeal unit 3.

[0101] The intestinal ventilation device 1 of this embodiment performs intestinal ventilation under the control of the control unit 90. Before the intestinal ventilation procedure, the intestinal ventilation device 1 is set to a position in the intestine where intestinal ventilation is possible. At this time, the balloon section 21 and the balloon section 51 are contracted in diameter. First, the intestinal insertion section 2 of the intestinal ventilation device 1 is inserted from the anus of the patient. The propelling section 10 inserted from the anus into the intestine does not expand in diameter in a spiral shape, as shown in FIG. 2. After the propulsion part 10 is inserted into the intestine through the anus, driving pressure is supplied to the three tubes 11, causing the propulsion part 10 to advance inside the intestine.

[0102] Fig. 4 is a diagram showing the pressurizing operation of the propelling part of the intestine ventilation device of this embodiment, and Fig. 5 is a diagram showing the relationship between the pressurized state of the propelling part of the intestine ventilation device of this embodiment and the helical pitch. The propulsion drive unit 13 and control valve 15, controlled by the control unit 90, alternately send compressed air to the first tube 11a, the second tube 11b, and the third tube 11c, which are elastic silicone tubes with closed tips, at different timings, as shown in Fig. 4. As a result, each tube deforms at different timings, as shown in Fig. 5. As a result, the tube assembly 11 becomes a spiral body 11s, as shown in Fig. 3, and this spiral body 11s advances into the intestines while tracing a spiral trajectory.

[0103] The deformation state of the spiral body 11s is shown in FIG. D: Diameter of the spiral formed by the center of the tube after deformation d: diameter of silicone tube L0: Length of the body axis per pitch L1: Tube length per pitch α: Tube axial elongation rate β: Radial elongation rate L'1 = α*L1 A: Outer diameter of the device after deformation A=D+βd is.

[0104] The propulsion unit 10, which is a soft robot, smoothly propels itself along the intestinal tract, preferably the large intestine and rectum. As the propulsion unit 10 advances, the entire intestinal insertion unit 2 is pulled and advances into the intestine. When the flange unit 55 advances until it is positioned near the outside of the anus, the driving of the propulsion drive unit 13 is stopped. The propulsion unit 10 is released from pressure and no longer spirals. The pressure applied to the intestine is also released. In this state, the intestinal insertion unit 2 has completed setting to the intestinal ventilation position. Note that the balloon units 21 and 51 maintain their reduced diameters.

[0105] 6 is a schematic diagram showing the intestinal ventilation treatment state of the intestinal ventilation device of this embodiment. Note that some components are omitted from the illustration of FIG. 6. At this time, the retention section 20 has reached position C1 before the small intestine in the intestine, as shown in Figure 6. The supply port 33 of the inlet section 30 is inserted deep into the large intestine and is positioned near position C1 before the small intestine. The propulsion section 10, which is a soft robot, spontaneously passes through bent section C2, which has a small radius of curvature, to reach position C1 before the small intestine. At the same time, the stopper portion 59 is positioned near the anus C0. The balloon portion 51 is positioned inside the rectum C3 near the anus C0. The flange portion 55 is positioned outside the intestine near the anus C0. The intestinal insertion portion 2 extends along the entire length of the large intestine C. The intestinal insertion portion 2 is bent along the large intestine C at a bending portion C2 inside the intestine.

[0106] Next, the placement drive unit 23 controlled by the control unit 90 supplies compressed air to expand the diameter of the balloon portion 21. Then, at a position C1 before the small intestine in the intestine, the balloon portion 21 comes into contact with the entire circumference in the radial direction and blocks the intestine, as shown in Fig. 6. The deployed balloon portion 21 becomes capable of sealing off the inflow of liquid into the small intestine.

[0107] Next, the outlet placement drive unit 53 controlled by the control unit 90 supplies compressed air to expand the diameter of the balloon unit 51. Then, at position C3 in the rectum near the anus C0, the balloon portion 51 comes into contact with the entire circumference in the radial direction and blocks the inside of the rectum, as shown in Fig. 6. The deployed balloon portion 51 becomes capable of sealing off the outflow of liquid from the anus to the outside of the body.

[0108] Next, in the liquid circulation gas exchange unit 70, the pump 75 and control valve 76 controlled by the control unit 90 supply the oxygenated liquid from the inlet unit 30 to the intestines. The supply pressure and supply flow rate of the oxygenated liquid supplied to the intestines are measured by the pressure sensor 62 and the flow rate sensor 63. In the liquid circulation gas exchange unit 70, the oxygenator 74 controlled by the controller 90 sets the oxygen concentration and carbon dioxide concentration of the supplied oxygenated liquid within predetermined ranges.

[0109] The oxygenated liquid can be a perfluorocarbon (PFC) with dissolved oxygen. The oxygenated liquid can be a perfluorodecarbon (PFD) with dissolved oxygen. The oxygenated liquid delivered to the intestine has a higher oxygen partial pressure than the blood oxygen partial pressure. The oxygenated liquid delivered to the intestine has a higher oxygen partial pressure than the blood oxygen partial pressure in the blood vessels of the intestinal wall. The oxygenated liquid delivered to the intestine has a carbon dioxide concentration sufficient to adsorb carbon dioxide in the blood and reduce the carbon dioxide concentration in the blood.

[0110] The supplied oxygenated liquid flows into the intestine from the supply port 33 via the inlet tube 31. The supplied oxygenated liquid is pressurized. The pressurized oxygenated liquid causes the large intestine C to expand. The pressure of the oxygenated liquid in the intestine is measured by the pressure sensor 61. At this time, the expanded balloon portion 21 blocks the flow of liquid into the small intestine. The oxygenated liquid in the intestine flows toward the anus C0. In Figure 6, the flow state of the oxygenated liquid in the intestine is indicated by arrows.

[0111] Near the anus C0, the deployed balloon portion 51 blocks outflow from the anus to the outside of the body. Therefore, the oxygenated liquid that reaches the vicinity of the anus C0 is discharged through the outlet 43 to the outlet conduit 42 outside the body. Note that feces, solid matter, liquid, etc. other than the oxygenated liquid that has been present in the intestines are also discharged through the outlet 43 to the outlet conduit 42 outside the body. In the outlet conduit 42, the flow rate is measured by a flow rate sensor 64.

[0112] In the intestine, the flowing oxygenated liquid carries out gas exchange throughout the body, adding oxygen to the blood and removing carbon dioxide through the intestinal wall. This gas exchange can occur along the intestinal tract between position C1 before the small intestine and position C3 in the rectum, i.e., along almost the entire length of the large intestine and rectum. In the subject's intestinal tract, preferably the large intestine and rectum, oxygen dissolved in the perfluorocarbon permeates the intestinal mucosa, transferring the dissolved oxygen into the blood. In the oxygenated liquid, gases dissolved in the blood, particularly carbon dioxide, are adsorbed by the perfluorocarbon, reducing the carbon dioxide concentration in the blood.

[0113] The oxygenated liquid flowing out of the outlet 40 has a lower oxygen concentration due to gas exchange with the blood, and an increased carbon dioxide concentration due to absorption from the blood. Therefore, although it is not accurate to call it an oxygenated liquid, this term is used because it is the same perfluorocarbon. The oxygenated liquid is pumped from the outlet 40 to the liquid circulation gas exchange section 70 .

[0114] The liquid circulation gas exchange unit 70 removes contents such as feces from the oxygenated liquid discharged from the outlet 40 in the filter unit 71. The liquid circulation gas exchange unit 70 adjusts the temperature of the oxygenated liquid to a predetermined value in the temperature adjustment unit 72 controlled by the control unit 90. The liquid circulation gas exchange unit 70 separates and removes gas contained in the oxygenated liquid discharged from the outlet 40 in the gas-liquid separation unit 73. The liquid circulation / gas exchange unit 70 performs gas exchange of the oxygenated liquid in the oxygenator 74 controlled by the controller 90, enabling it to be circulated. Specifically, the oxygenator 74 removes carbon dioxide from the oxygenated liquid to reduce the carbon dioxide concentration, and adds carbon dioxide to the oxygenated liquid to increase the oxygen concentration.

[0115] The liquid circulation / gas exchange unit 70 pressurizes the oxygenated liquid using a pump 75 controlled by the control unit 90, and supplies and circulates the liquid again into the intestines. This allows for continuous supply of fresh oxygenated liquid to the intestines, enabling long-term intestinal ventilation while maintaining high gas exchange efficiency.

[0116] This embodiment provides an intestinal ventilation device 1 that enables efficient intestinal ventilation through continuous administration of O2-PFD and continuous gas exchange through circulation. Furthermore, the self-propelled propulsion of the propulsion unit 10 allows the intestinal insertion unit 2 to be easily inserted to a predetermined position deep within the intestine, eliminating the need for highly specialized techniques, unlike colonoscopy. At the same time, the inlet unit 30 and outlet unit 40 can be positioned apart along the length of the intestine to perform intestinal ventilation, thereby expanding the intestinal area available for gas exchange and enabling efficient gas exchange. Furthermore, the liquid circulation gas exchange unit 70 continuously oxygenates the PFD and removes carbon dioxide outside the body, while maintaining a circulatory state in which a predetermined amount of oxygenated liquid (O2-PFD) is continuously delivered to the intestine, facilitating long-term intestinal ventilation. This reduces invasiveness to the patient and facilitates safe ventilation.

[0117] Furthermore, the control unit 90 controls the liquid circulation / gas exchange unit 70 based on the measurement value of the measurement unit 60, thereby enabling sustained and efficient intestinal ventilation.

[0118] Specifically, the control unit 90 controls the pump 75 and the control valve 76 based on the measurement value of the pressure sensor 61. When the measurement value of the pressure sensor 61 is high, the control unit 90 controls the pump 75 and the control valve 76 to decrease the pressure of the oxygenated liquid in the intestine. When the measurement value of the pressure sensor 61 is low, the control unit 90 controls the pump 75 and the control valve 76 to increase the pressure of the oxygenated liquid in the intestine. This makes it possible to maintain a suitable range of intestinal pressure for intestinal ventilation.

[0119] Furthermore, the control unit 90 controls the pump 75 and the control valve 76 based on the measurements of the pressure sensor 62 and the flow rate sensor 63. When the measurements of the pressure sensor 62 and the flow rate sensor 63 are high, the control unit 90 controls the pump 75 and the control valve 76 to decrease the pressure and flow rate of the oxygenated liquid in the intestine. When the measurements of the pressure sensor 62 and the flow rate sensor 63 are low, the control unit 90 controls the pump 75 and the control valve 76 to increase the pressure and flow rate of the oxygenated liquid in the intestine. This makes it possible to maintain a range of intestinal pressure and flow rate of the oxygenated fluid in the intestine that is suitable for intestinal ventilation.

[0120] Furthermore, the control unit 90 controls the pump 75 and the control valve 76 based on the measurement value of the flow rate sensor 64. When the measurement value of the flow rate sensor 64 is high, the control unit 90 controls the pump 75 and the control valve 76 to decrease the flow rate of the oxygenated liquid in the intestine. When the measurement value of the flow rate sensor 64 is low, the control unit 90 controls the pump 75 and the control valve 76 to increase the flow rate of the oxygenated liquid in the intestine. This makes it possible to maintain a range of flow rates of the oxygenated fluid suitable for intestinal ventilation.

[0121] Furthermore, it is possible to perform intestinal ventilation by combining the above controls.

[0122] In this embodiment, the insertion position of the intestinal insertion portion 2 can be detected during the intestinal ventilation procedure or while the intestinal insertion portion 2 is being set before the intestinal ventilation procedure. Figure 7 is an image showing an X-ray fluoroscopic image of the intestinal ventilation treatment performed by the intestinal ventilation device of this embodiment, taken in an animal experiment using a pig. Specifically, for example, the abdomen of the patient is fluoroscopically viewed using an X-ray device such as an X-ray device before or after the insertion of the intestinal insertion portion 2. Then, as shown in Fig. 7, the insertion position of the intestinal insertion portion 2 in the intestine can be determined by the X-ray fluoroscopic marker 2x. In the example shown in Fig. 7, the X-ray fluoroscopy markers 2x are spherical. Adjacent X-ray fluoroscopy markers 2x are set to be approximately equal in size. In the image shown in Fig. 7, it can be seen that the posture of the intra-intestinal insertion portion 2 can be determined from the change in the distance between adjacent X-ray fluoroscopy markers 2x.

[0123] This information makes it possible to adjust the intestinal insertion position of the intestinal insertion section 2, particularly the position of the retention section 20 in the intestine. This makes it possible to easily set the intestinal tract length within a predetermined range, thereby enabling efficient intestinal ventilation and preventing a decrease in intestinal ventilation efficiency. Moreover, this intestinal insertion position information acquisition, intestinal insertion position determination, and intestinal insertion position correction can be performed simply and quickly. This can also be done, for example, at the scene of emergency treatment.

[0124] The X-ray fluoroscopy marker 2x can also be provided on the balloon portion 21. In this case, it becomes easy to confirm the expanded diameter state of the balloon portion 21. Furthermore, it becomes easy to confirm directly whether the balloon portion 21 is sufficiently blocking the intestinal tract, rather than indirectly by using a sensor for intestinal pressure, flow rate, or the like.

[0125] The subject of intestinal ventilation is a mammal, particularly a primate, such as a human, a quadruped, or the like. For example, dogs, cats, hamsters, guinea pigs, horses, cows, sheep, pigs, camels, goats, and avian species, such as birds. The subject is in particular a human.

[0126] A "perfluorocarbon" is a molecule in which all hydrogen atoms of a hydrocarbon have been replaced with fluorine atoms. Perfluorocarbons may include straight-chain alkyl, branched alkyl, and cycloalkyl. Perfluorocarbons may have one or more carbon atoms replaced by an atom selected from the group consisting of O, N, and S. Perfluorocarbons (PFCs) are known for their high oxygen solubility. Perfluorocarbons can be liquids at room temperature. Perfluorocarbons can dissolve approximately 20 times more oxygen gas than water.

[0127] "Oxygen" refers to O2. Oxygen gas is highly soluble in liquid perfluorocarbons. In the atmosphere, oxygen typically accounts for about 21%.

[0128] Enteral ventilation can be used, for example, for oxygen therapy, which refers to a procedure that provides oxygen to a subject with the goal of ameliorating respiratory failure in the subject.

[0129] "Respiratory failure" is defined as a condition in which arterial blood gases show abnormal values, preventing the body from functioning normally. Hypoxemic respiratory failure (hypoxemia) refers to a respiratory dysfunction or equivalent abnormal condition in which the arterial blood oxygen partial pressure (PaO2) is 60 mmHg (approximately 8,000 Pa) or less when breathing room air. Respiratory failure is broadly divided into type I and type II respiratory failure. Type I respiratory failure is respiratory failure in which the PaO2 is 45 mmHg (approximately 6,000 Pa) or less, while type II respiratory failure is respiratory failure in which the PaO2 exceeds 45 mmHg (approximately 6,000 Pa). Pre-respiratory failure refers to a condition in which the PaO2 exceeds 60 mmHg (approximately 8,000 Pa) but is 70 mmHg (approximately 9,333 Pa) or less. 1 mmHg is equivalent to 1 Torr or 101,325 / 760 Pa. Respiratory failure can be caused, for example, by pneumonia (e.g., viral pneumonia caused by influenza virus, measles virus, coronavirus, and varicella virus, bacterial pneumonia caused by Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pneumonia, and atypical pneumonia caused by microorganisms such as mycoplasma and chlamydia).

[0130] Oxygen is added to oxygenated liquids as a gas. "Gas" means a gas. Gas may be in gaseous form or dissolved in a liquid. Unless otherwise specified, gas means the gas in gaseous form.

[0131] Oxygenated Liquid, "oxygen-containing liquid" means a liquid having dissolved O2.

[0132] "Intestinal tract" refers to the small intestine and large intestine. The large intestine includes the colon and rectum. Large intestinal administration and rectal administration do not exclude administration from outside the body by making a hole in the large intestine or rectum, but preferably may be administration via the anus. Large intestinal administration or rectal administration may preferably be administration using an administration device such as an enema device. Large intestinal administration or rectal administration may also be administration via an artificial anus (e.g., via a stoma).

[0133] Perfluorocarbons are liquids at room temperature. Perfluorocarbons and other highly fluorinated liquids have a high affinity for gases; for example, they can dissolve oxygen 20 times more than water. PFC liquids are also inert and have low or no toxicity (Riess, (1984) Artificial Organs, 8: 34-56). Mammals can breathe oxygenated perfluorocarbons without long-term side effects and subsequently return to air breathing (Modell et al., (1970) Federation Proc., 29: 1731-1739; Modell et al., (1976) Chest, 69: 79-81). Here, oxygenated perfluorocarbon refers to perfluorocarbons that have dissolved oxygen by bubbling oxygen through the perfluorocarbon liquid. The fluorocarbon molecules used in the present invention can have a variety of structures, including linear or branched chain, or cyclic structures (Riess, (1984) Artificial Organs, 8: 34-56). Preferably, the fluorocarbon has from about 2, 3, 4, or 5 carbon atoms to about 10, 12, or 14 carbon atoms.

[0134] There are many fluorocarbons that can be used in this embodiment, including perfluorocarbons that may have some degree of unsaturation and may contain bromine or hydrogen atoms, or they may be amine derivatives, but it is preferred that all hydrogen atoms in the fluorocarbons be replaced with fluorine. Fluorocarbons include bis(F-alkyl)ethanes, such as C4F9=CH4CF9 (sometimes referred to as "F-44E"), i-C3F9=CHCF 13 ("F-i36E"), and C6F 13 CH=CHC6CF 13 ("F-66E"); cyclic fluorocarbons, e.g., C 10 F 18("F-decalin", "perfluorodecalin" or "FDC"), F-adamantane ("FA"), F-methyladamantane ("FMA"), F-1,3-dimethyladamantane ("FDMA"), F-di- or F-trimethylbicyclo[3,3,1]nonane ("nonane"); perfluorinated amines, such as F-tripropylamine ("FTPA") and F-tributylamine ("FTBA"), F-4-methyloctahydroquinolizine ("FMOQ"); "), Fn-methyldecahydroisoquinoline ("FMIQ"), Fn-methyldecahydroquinoline ("FHQ"), Fn-cyclohexylprolidone ("FCHP"), and F-2-butyltetrahydrofuran ("FC-75" or "RM101"), perfluorobutane, perfluoropropane, perfluoropentane, perfluorohexane, perfluoroheptane, or perfluorooctane. Both linear and branched isomers are contemplated.

[0135] Other suitable fluorocarbons are brominated perfluorocarbons, such as 1-bromo-heptadecafluorooctane (CF 17 Br, "PFOB", perflubron or perflubron), 1-bromopenta-decafluorohexane (CF 13 Br, "PFHB"). Other brominated fluorocarbons are disclosed in U.S. Patent No. 3,975,512 to Long. Fluorocarbons having non-fluorine substituents, such as perfluorooctyl chloride and perfluorooctyl hydrogen, as well as those having different numbers of carbon atoms, e.g., 6-12 carbon atoms, are also contemplated. Other fluorocarbons contemplated according to the present invention include perfluoroalkylated ethers or polyethers, such as (CF3)2CFO(CF2CF2)2OCF(CF3)2, (CF3)2CFO(CF2CF2)3OCF(CF3), (CF3)CFO(CF2CF2)F, (CF3)2CFO(CF2CF2)2F, (CF3) 13 )2O. Additionally, fluorocarbon-hydrocarbon compounds such as those of the general formula C are included (as long as the compounds are liquid at room temperature). n F2n+1 C n’ F 2n’+1 , CnF 2n+1 O.C. n’ F2 n’+1 , or C n F 2n+1 CF=CHC n’ F 2n’+1 [wherein n and n' are the same or different and range from about 1 to about 10. Such compounds include, for example, C8F 17 C2H5 and C6F 13 CH=CHC6H 13 is included.

[0136] In preferred embodiments, the perfluorocarbon (PFC) is one or more selected from the group consisting of, for example, perfluorooctane, perfluorobutylperfluorotetrahydrofuran, perfluoro-1-isopropoxyhexane, perfluoro-1,4-diisopropoxybutane, and octadecafluorodecahydronaphthalene. In other or further embodiments, the PFC in the composition is perfluorodecalin (PFD; C 10 F 18 ), perflubron (PFB; C8BrF 17 ), perfluoro-1,3-dimethylcyclohexane, FC-75, perfluorooctane, and perfluoro-octyl bromide. In some embodiments, the PFC is or includes a PFC having a cycloalkyl group, such as perfluorodecalin, perfluoro-1,3-dimethylcyclohexane, or FC-75.

[0137] The oxygenated liquid contains an effective amount of a perfluorocarbon with dissolved oxygen, the effective amount being an amount that, when administered enterally, preferably into the colon and rectum, transfers oxygen across the intact intestinal mucosa into the blood, thereby increasing the oxygen partial pressure in the blood (e.g., in the arteries, veins, pulmonary arteries, pulmonary veins, or left or right ventricles).

[0138] Oxygenated liquids are perfluorocarbons with dissolved oxygen, which have a higher oxygen partial pressure than the blood oxygen partial pressure. In human adults, oxygen saturation is approximately 98% at an oxygen partial pressure of 100 mmHg, approximately 95% at an oxygen partial pressure of 80 mmHg, and approximately 90% at an oxygen partial pressure of 60 mmHg. Therefore, perfluorocarbons with dissolved oxygen preferably have an oxygen partial pressure of, for example, 100 mmHg or more, 150 mmHg or more, 200 mmHg or more, or 250 mmHg or more. This makes it possible to achieve intestinal gas ventilation using perfluorocarbons.

[0139] In a preferred embodiment, oxygen can be artificially dissolved in perfluorocarbon. For example, dissolving oxygen in perfluorocarbon can be achieved by bubbling oxygen gas through a perfluorocarbon solution. For example, oxygen gas can be bubbled until the oxygen concentration in the perfluorocarbon is saturated or reaches 50% or more, 60% or more, 70% or more, 80% or more, or 90% or more of the saturated oxygen concentration. Bubbling can also be performed using a device that bubbles oxygen gas through a perfluorocarbon solution. The saturated concentration is the concentration at room temperature and atmospheric pressure. For example, a gaseous composition containing oxygen gas can be dissolved in perfluorocarbon before administration and then administered to the intestines of a subject. For example, an oxygenated liquid containing perfluorocarbon can have oxygen dissolved therein, or preferably, oxygen can be dissolved therein before administration and then administered to the intestines (preferably the large intestine and rectum) of a subject. Alternatively, an oxygenated liquid containing a perfluorocarbon with an effective amount of dissolved oxygen can be provided and administered to the intestines of a subject.

[0140] The oxygenated liquid preferably has an oxygen partial pressure of 250 mmHg or more under atmospheric conditions (oxygen concentration of approximately 21%), and therefore perfluorocarbons maintained under atmospheric conditions (or with dissolved oxygen under atmospheric conditions) can be used for intestinal ventilation.

[0141] In intestinal ventilation, when an oxygenated liquid is administered to a subject's intestinal tract, oxygen dissolved in the perfluorocarbon permeates the intestinal mucosa and transfers dissolved oxygen into the blood. This improves the subject's blood oxygen partial pressure. Therefore, the intestinal ventilation device 1 can be used to treat hypoxemia. The subjects to whom the oxygenated liquid is administered using the intestinal ventilation device 1 may be, for example, patients with an arterial blood oxygen saturation of 90 or less, 85 or less, 80 or less, 75 or less, 70 or less, 65 or less, or 60 or less. Furthermore, when the oxygenated liquid is administered to a subject's intestinal tract (preferably the large intestine) using the intestinal ventilation device 1 of the present invention, gases (particularly carbon dioxide) dissolved in the blood are adsorbed by the perfluorocarbon, resulting in a decrease in the carbon dioxide concentration in the blood.

[0142] Therefore, oxygenated liquid administered using the intestinal ventilator 1 of the present invention can be used to reduce blood gas concentrations (particularly blood carbon dioxide concentrations). The intestinal ventilator 1 can be used, for example, in patients with an arterial blood carbon dioxide partial pressure (PaCO2) of >45 mmHg. In diseases involving airway obstruction, such as asthma and chronic obstructive pulmonary disease (COPD), carbon dioxide cannot be sufficiently excreted, resulting in elevated blood carbon dioxide partial pressure. Therefore, the intestinal ventilator 1 of the present invention can be used to treat these diseases (or conditions) associated with elevated blood carbon dioxide partial pressure (e.g., greater than 45 mmHg). In certain embodiments, the intestinal ventilator 1 of the present invention can administer oxygenated liquid in a single dose, multiple doses, or continuously. Continuous administration is achieved by withdrawing the administered PFC and administering a new PFC. When used to reduce carbon dioxide partial pressure, the PFC does not need to be further oxygenated.

[0143] Hypoxemia is also induced in subjects with respiratory failure. Thus, the intestinal ventilation device 1 of the present invention can be used to treat respiratory failure in a subject. Also, the intestinal ventilation device 1 of the present invention can be used to treat hypoxemia in a subject with respiratory failure. Thus, the intestinal ventilation device 1 of the present invention can be used to oxygenate the blood of a subject.

[0144] The oxygenated liquid is a liquid formulation, which may further comprise a pharmaceutically acceptable excipient. Administration of oxygenated fluids can increase a person's blood oxygen tension and / or decrease their blood carbon dioxide tension. The oxygenated liquid is artificially oxygenated by the liquid circulation gas exchange unit 70. In a preferred embodiment, the artificial oxygenation may be achieved by bubbling oxygen through a perfluorocarbon-containing liquid in the oxygenator unit 74. Enteral ventilation with such an oxygenated liquid may increase a person's blood oxygen partial pressure and / or decrease their blood carbon dioxide partial pressure.

[0145] The perfluorocarbon in the oxygenated liquid may be perfluorodecalin. In one preferred embodiment, the perfluorocarbon may be perflubron.

[0146] A second embodiment of the intestinal ventilation device according to the present invention will now be described with reference to the drawings. 8 is a schematic diagram showing the vicinity of the tip of the inlet in the intestinal ventilation device of this embodiment. This embodiment differs from the first embodiment in terms of the supply port. Other components corresponding to those of the first embodiment are assigned the same reference numerals and will not be described further.

[0147] 8, in the inlet portion 30 of this embodiment, the supply port 33 is formed not at the tip of the inlet tube 31 but on the circumferential surface near the tip. The tip of the inlet tube 31 is closed.

[0148] This configuration prevents the supply port 33 from being blocked by feces or the like when the intestinal insertion portion 2 enters the intestine, thereby enabling the oxygenated liquid to be supplied smoothly. At the same time, even when intestinal ventilation needs to be started quickly in emergency treatment or the like, there is no need to redo the insertion of the intestinal insertion portion 2 due to intestinal ventilation not working properly due to blockage of the supply port 33.

[0149] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0150] A third embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. 9 is a schematic diagram showing the vicinity of the tip of the inlet of the intestinal ventilation device of this embodiment. This embodiment differs from the second embodiment described above in terms of the supply port. Other components corresponding to those of the second embodiment described above are assigned the same reference numerals and will not be described again.

[0151] 9, in the inlet portion 30 of this embodiment, a plurality of supply ports 33 are formed on the circumferential surface near the tip of the inlet tube 31. The plurality of supply ports 33 are arranged spaced apart from one another in the axial direction of the inlet tube 31. The tip of the inlet tube 31 is closed. The inlet section 30 also has small supply ports 33s. The small supply ports 33s are arranged at positions closer to the base end of the intestinal insertion section 2 than the tip of the inlet tube 31. The small supply ports 33s each have a smaller opening area than the supply port 33. The multiple small supply ports 33s are arranged spaced apart from one another in the axial direction of the inlet tube 31.

[0152] This configuration prevents the supply port 33 and the small supply port 33s from being blocked by feces or the like when the intestinal insertion section 2 enters the intestine, enabling the oxygenated liquid to be supplied smoothly. In addition to the oxygenated liquid supplied from the supply port 33 located deep inside the intestine, additional oxygenated liquid can be supplied into the intestine from the small supply port 33s downstream in the flow direction of the oxygenated liquid within the intestine. Therefore, even if the oxygen concentration in the oxygenated liquid supplied from the supply port 33 decreases or the carbon dioxide concentration increases, oxygenated liquid with a high oxygen concentration or a low carbon dioxide concentration can be added from the small supply port 33s, so the efficiency of intestinal ventilation does not decrease. At the same time, even when rapid initiation of intestinal ventilation is required in emergency treatment, etc., it is possible to maintain high efficiency of gas exchange.

[0153] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0154] A fourth embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. 10 is a schematic diagram showing the vicinity of the tip of the inlet of the intestinal ventilation device of this embodiment. This embodiment differs from the third embodiment in terms of the supply port. Other components corresponding to those of the third embodiment are assigned the same reference numerals and will not be described again.

[0155] 10, the inlet portion 30 of this embodiment has a plurality of supply ports 33 and small supply ports 33s formed on the circumferential surface of the inlet tube 31 over the entire length from the tip to the base end. The plurality of supply ports 33 and small supply ports 33s are arranged spaced apart from one another in the axial direction of the inlet tube 31. The tip of the inlet tube 31 is closed.

[0156] This configuration prevents the supply port 33 and the small supply port 33s from being blocked by feces or the like when the intestinal insertion section 2 enters the intestine, enabling a smooth supply of oxygenated liquid. Since the oxygenated liquid supplied from the supply ports 33 and small supply ports 33s located along the entire length of the intestine can be used for intestinal ventilation, additional oxygenated liquid can be supplied to the intestine from the supply ports 33 and small supply ports 33s located sequentially downstream in the flow direction of the oxygenated liquid within the intestine. Therefore, even if the oxygen concentration in the supplied oxygenated liquid decreases or the carbon dioxide concentration increases, oxygenated liquid with a high oxygen concentration or a low carbon dioxide concentration can be supplied throughout the entire intestinal tract from the small supply ports 33s, further improving the efficiency of intestinal ventilation. At the same time, even when rapid initiation of intestinal ventilation is required in emergency treatment, etc., it becomes possible to maintain a much higher efficiency of gas exchange.

[0157] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0158] A fifth embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. 11 is a schematic diagram showing the indwelling section of the intestinal ventilation device of this embodiment. This embodiment differs from the first embodiment in terms of the indwelling section, and other components corresponding to those of the first embodiment are assigned the same reference numerals and will not be described further.

[0159] 11, in the indwelling section 20 of this embodiment, the indwelling drive section 23 supplies a liquid as a driving pressure. In addition, an oxygenated liquid is used as the liquid that supplies the driving pressure. In the indwelling section 20, a supply port 33 opens into a driving pressure supply pipe line 22 connected to the balloon section 21. In this embodiment, the driving pressure supply line 22 can also serve as an inlet tube. In this embodiment, the size of the supply port 33 can be set by the ratio between the amount of driving fluid required to expand the diameter of the balloon portion 21 and the flow rate of the oxygenated liquid to be supplied into the intestine.

[0160] This configuration makes it possible to reduce the diameter of the intestinal insertion portion 2. Furthermore, in the intestinal ventilation device 1, the number of parts of the intestinal insertion portion 2 can be reduced.

[0161] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0162] A sixth embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. 12 is a schematic diagram showing the indwelling section of the intestinal ventilation device of this embodiment. This embodiment differs from the first embodiment described above in terms of the indwelling section, and other components corresponding to those of the first embodiment described above are assigned the same reference numerals and will not be described again.

[0163] 12, in the retention section 20 of this embodiment, X-ray fluoroscopy markers 2x are placed on the balloon section 21. A plurality of X-ray fluoroscopy markers 2x are provided around the periphery of the balloon section 21 at positions that will result in the maximum diameter dimension when the balloon section 21 is expanded. The plurality of X-ray fluoroscopy markers 2x are spaced apart at equal distances from one another in the circumferential direction of the balloon section 21. The X-ray fluoroscopy markers 2x in this embodiment are metal foils with triangular contours. The X-ray fluoroscopy markers 2x are arranged in the circumferential direction of the balloon portion 21 with their apexes facing in the same direction. The X-ray fluoroscopy marker 2x is positioned so as not to hinder the expansion and contraction of the diameter of the balloon portion 21. Alternatively, the X-ray fluoroscopy marker 2x is a metal piece having a thickness that allows it to deform in accordance with the expansion and contraction of the diameter of the balloon portion 21.

[0164] With this configuration, the abdomen of the patient is viewed by an X-ray device such as an X-ray device before or after the insertion of the intestinal insertion portion 2. This allows the multiple X-ray fluoroscopy markers 2x to be distinguished. The X-ray fluoroscopy markers 2x make it possible to determine the insertion position of the intestinal insertion portion 2 in the intestine. At the same time, it becomes easy to check the expanded diameter state of the balloon portion 21. It also becomes easy to check whether the balloon portion 21 is sufficiently blocking the intestinal tract. Furthermore, by checking the orientation of the X-ray fluoroscopy markers 2x together with an image of the intestinal tract, the posture, expanded diameter state, and blocking state of the balloon portion 21 can be easily checked. The X-ray fluoroscopy marker 2x may have a shape other than a triangular flake, as long as the contour shape allows its orientation to be identified under X-ray fluoroscopy.

[0165] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0166] In each of the above-described embodiments, the outlet indwelling section 50 may be configured so that the position of the balloon section 51 is adjustable. In this case, the length of the balloon portion 51 can be adjusted by changing its position relative to the flange portion 55 in the length direction of the intestinal insertion portion 2. At the same time, the length of the balloon portion 51 can be changed relative to the stopper portion 59 in the length direction of the intestinal insertion portion 2. This ensures that the anus C0 is sufficiently sealed, and prevents the oxygenated liquid from leaking from anywhere other than the outlet portion 40, even when the insertion length of the intestinal insertion portion 2 is changed.

[0167] A seventh embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. Fig. 13 is a schematic diagram showing the intestinal ventilation device of this embodiment. This embodiment differs from the first embodiment described above in terms of the measurement unit and control, and the positions of the inlet and outlet. Other components corresponding to those of the first embodiment described above are assigned the same reference numerals and will not be described again.

[0168] As shown in FIG. 13, the intestinal ventilation device 1 of this embodiment has a measurement unit 60 that includes a blood oxygen concentration sensor 67 that measures the blood oxygen concentration of the subject, and a sensor 68 that measures the blood carbon dioxide concentration of the subject.

[0169] The blood oxygen concentration sensor 67 and the blood carbon dioxide concentration sensor 68 are connected to the patient. The blood oxygen concentration sensor 67 and the blood carbon dioxide concentration sensor 68 are connected to the control unit 90 via a control line 69. The blood oxygen concentration sensor 67 and the blood carbon dioxide concentration sensor 68 constitute the extracorporeal unit 3. In this embodiment, during intestinal ventilation, the blood oxygen concentration of the patient is measured by the blood oxygen concentration sensor 67, and the blood carbon dioxide concentration of the patient is measured by the blood carbon dioxide concentration sensor 68. The blood oxygen concentration sensor 67 and the blood carbon dioxide concentration sensor 68 monitor the blood concentrations. The control unit 90 controls the liquid circulation gas exchange unit 70 based on the measurements of the blood oxygen concentration sensor 67 and the blood carbon dioxide concentration sensor 68.

[0170] Specifically, when the blood oxygen concentration measured by the blood oxygen concentration sensor 67 is high, the control unit 90 controls the pump 75 and the control valve 76 to reduce the pressure and flow rate of the oxygenated liquid in the intestine. When the blood oxygen concentration measured by the blood oxygen concentration sensor 67 is high, the control unit 90 controls the oxygenator 74 to reduce the amount of oxygenated liquid added to the intestine. When the blood oxygen concentration measured by the blood oxygen concentration sensor 67 is low, the control unit 90 controls the pump 75 and the control valve 76 to increase the pressure and flow rate of the oxygenated liquid in the intestine. When the blood oxygen concentration measured by the blood oxygen concentration sensor 67 is low, the control unit 90 controls the oxygenator 74 to increase the amount of oxygenated liquid added to the intestine. This makes it possible to maintain an oxygen content range suitable for intestinal ventilation.

[0171] Furthermore, when the blood carbon dioxide concentration measured by the blood carbon dioxide concentration sensor 68 is high, the control unit 90 controls the pump 75 and the control valve 76 to increase the pressure and flow rate of the oxygenated liquid in the intestine. When the blood carbon dioxide concentration measured by the blood carbon dioxide concentration sensor 68 is high, the control unit 90 controls the oxygenator 74 to increase the amount of carbon dioxide removed by the oxygenated liquid. When the blood carbon dioxide concentration measured by the blood carbon dioxide concentration sensor 68 is high, the control unit 90 controls the oxygenator 74 to increase the amount of oxygenated liquid added to the intestine.

[0172] When the blood carbon dioxide concentration measured by the blood carbon dioxide concentration sensor 68 is low, the control unit 90 controls the pump 75 and the control valve 76 to reduce the pressure and flow rate of the oxygenated liquid in the intestine. When the blood carbon dioxide concentration measured by the blood carbon dioxide concentration sensor 68 is low, the control unit 90 controls the oxygenator 74 to reduce the amount of oxygenated liquid added to the intestine. This makes it possible to maintain a carbon dioxide content range suitable for intestinal ventilation.

[0173] Furthermore, it is possible to perform intestinal ventilation by combining the control of this embodiment with the control of the above-described embodiment.

[0174] 13, the intestinal ventilation device 1 of this embodiment has the inlet 30 and outlet 40 in the intestinal insertion section 2 reversed in position compared to the first embodiment shown in FIG. 1. That is, the outlet 40 of this embodiment is disposed close to the tip of the intestinal insertion section 2. The inlet 30 of this embodiment is disposed close to the base end of the intestinal insertion section 2.

[0175] In the intestinal ventilation of this embodiment, the supply port 33 is located in a position close to the anus C0, and the discharge port 43 is located in the intestine at a position C1 just before the small intestine behind the balloon portion 21. In this embodiment, the supply port 33 and the discharge port 43 are in a positional relationship interchanged with that of the first embodiment. With this arrangement, the oxygenated liquid supplied by the liquid circulation / gas exchange unit 70 flows from the vicinity of the anus C3 to a position C1 before the small intestine inside the intestine, thereby performing intestinal ventilation.

[0176] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0177] Furthermore, in the present invention, it is also possible to individually select and combine the individual configurations in the above-described embodiments.

[0178] Furthermore, in the above embodiment, the propulsion unit 10 is provided at a position closer to the tip of the intestinal insertion section 2 than the balloon section 21, but the propulsion unit 10 can also be provided at a position closer to the base end of the intestinal insertion section 2 than the balloon section 21. That is, in the above embodiment, the propulsion unit 10 is provided at a position further forward in the direction of travel than the balloon section 21, but the propulsion unit 10 can also be provided at a position further backward in the direction of travel than the balloon section 21.

[0179] In addition, the propelling section 10 may be disposed at both a position closer to the tip of the intestinal insertion section 2 relative to the balloon section 21 and a position closer to the base end of the intestinal insertion section 2 than the balloon section 21. In other words, in the configuration shown in Fig. 1, the balloon section 21 may be configured to be sandwiched between two propelling sections 10 in the longitudinal direction of the intestinal insertion section 2.

[0180] 11, an oxygenated liquid is used as the liquid that supplies the driving pressure to the balloon section 21, and the driving pressure supply pipe 22 can also be used as the inlet tube. As a result, the portion of the propulsion section 10 that is closer to the rear end of the intestinal insertion section 2 than the balloon section 21 is composed of four tubes: three tubes 11 and the driving pressure supply pipe 22.

[0181] Alternatively, it is also possible to arrange the propelling sections 10 at all positions facing forward from the stopper section 59 of the intraintestinal insertion section 2, and arrange the balloon section 21 at a position close to the tip 10a.

[0182] An eighth embodiment of the intestinal ventilation apparatus according to the present invention will now be described with reference to the drawings. Figure 14 is a schematic diagram showing the intestinal ventilation device of this embodiment, and Figure 15 is a schematic cross-sectional view showing the tube assembly portion of the intestinal ventilation device of this embodiment. This embodiment differs from the first embodiment described above in terms of the propulsion section and the retention section. Other configurations corresponding to those of the first embodiment described above are given the same reference numerals and descriptions thereof will be omitted.

[0183] In this embodiment, the intestinal insertion section 2 includes an indwelling section 20, a propelling section 10, an inlet section 30, and a measuring section 60, as shown in Fig. 14. The intestinal insertion section 2 has the indwelling section 20 disposed at the distal end section 2a. The intestinal insertion section 2 also has the propelling section 10, the inlet section 30, and the driving pressure supply pipe 22 arranged in parallel at a position closer to the proximal end section 2b than the indwelling section 20. The intestinal insertion section 2 has the indwelling section 20 disposed at the forefront in the direction of progression during insertion. Here, the tip end 2a of the intestinal insertion portion 2 is the forward end in the insertion direction into the intestine. The base end 2b of the intestinal insertion portion 2 is the rearward end in the insertion direction into the intestine. The base end 2b of the intestinal insertion portion 2 is located near the anus when the intestinal insertion portion 2 is inserted into the intestine. When the intestinal insertion portion 2 is inserted into the intestine, the intestinal insertion portion 2 can advance inside along the intestinal tract.

[0184] In this embodiment, the tube assembly 11 has a first tube 11a, a second tube 11b, and a third tube 11c. As shown in Fig. 15, the tube assembly 11 has a driving pressure supply pipe line 22 and an inlet tube 31 arranged at the radial center thereof. The driving pressure supply pipe 22 and the inlet tube 31 are surrounded radially outward by a first tube 11a, a second tube 11b, and a third tube 11c which are spirally wound or twisted together.

[0185] The driving pressure supply pipe 22, the inlet tube 31, the first tube 11a, the second tube 11b, and the third tube 11c are bundled together and extend in the longitudinal direction of the intestinal insertion section 2. The first tube 11a, the second tube 11b, and the third tube 11c can be spirally wound or twisted together with the driving pressure supply pipe line 22 and the inlet tube 31 positioned in the center, and then silicone rubber can be applied to and coated on the surfaces of the tubes to bond them together to form the tube assembly 11.

[0186] In this embodiment, the tube assembly 11 may extend over substantially the entire length of the intestinal insertion section 2. Alternatively, the tube assembly 11 may be located at the distal end 2a of the intestinal insertion section 2, and connected to the first driving pressure supply line 12a, the second driving pressure supply line 12b, and the third driving pressure supply line 12c at a position close to the proximal end 2b. The first driving pressure supply line 12a, the second driving pressure supply line 12b, and the third driving pressure supply line 12c may be bundled together, and may not be spirally wound or twisted together like the first tube 11a, the second tube 11b, and the third tube 11c. Even in this case, the driving pressure supply line 22 and the inlet tube 31 are surrounded radially outward by the first driving pressure supply line 12a, the second driving pressure supply line 12b, and the third driving pressure supply line 12c.

[0187] In this embodiment, the balloon section 21 is disposed at the tip end 2a, which is further forward in the direction of travel than the propulsion section 10, as shown in FIG. The balloon portion 21 is set so that the radial dimension in a reduced diameter state where it is not pressurized by the placement drive portion 23 is smaller than the minimum spiral diameter D1 of the spiral body 11s. It is preferable that the axial dimension of the balloon portion 21 along the spiral central axis Ah (see FIG. 3) is smaller than the radial dimension when the balloon portion 21 is in an expanded diameter state pressurized by the placement drive unit 23. Alternatively, it is preferable that the radial dimension of the balloon portion 21 along the spiral central axis Ah when the balloon portion 21 is in an expanded diameter state pressurized by the placement drive unit 23 is the same as the axial dimension of the balloon portion 21 along the spiral central axis Ah. By setting the balloon portion 21 to the above dimensions in the expanded and contracted diameter states, it becomes possible to suitably insert the intestinal insertion portion 2 into the intestinal tract and to suitably lock the intestinal insertion portion 2.

[0188] In this embodiment, the inlet portion 30 has a supply port 33 at a position axially adjacent to the balloon portion 21, as shown in Figure 14. The supply port 33 is provided at a position adjacent to the balloon portion 21 of the tube assembly 11. The supply port 33 is provided at a position adjacent to the tip portion 2a of the tube assembly 11.

[0189] In this embodiment, the same effects as those of the above-described embodiment can be achieved.

[0190] <1A> An intestinal ventilation device according to one aspect of the present invention, 1. An intestinal ventilation device for administering oxygenated liquid into the intestine, comprising: Promotion Department and a retention section for retaining the oxygenated liquid in a predetermined region within the intestine; an inlet portion for supplying the oxygenated liquid into the intestine; a liquid circulation / gas exchange unit that supplies the oxygenated liquid to the inlet unit and circulates the discharged liquid by gas exchange; a propulsion drive unit that propels and drives the propulsion unit; a placement drive unit that drives the placement unit; Equipped with the propulsion section, the retention section, and the inlet section constitute an intestinal insertion section to be inserted into the intestine. It is possible.

[0191] <4A> The intestinal ventilation device of the present invention is <3> In The detention section has the balloon section positioned at the leading end of the propulsion section in the direction of travel. It is possible. [Explanation of symbols]

[0192] 1. Intestinal ventilation device 2...Intestinal insertion part 2x...X-ray fluoroscopy marker 3...Extracorporeal placement part 10…Promotion Department 11...Pipe assembly 11a, 11b, 11c...Tube 11s…Spiral 12...Drive pressure supply line (line) 13...Propulsion drive unit (driving pressure source) 14...Drive pressure supply outer pipe (pipe) 15...Control valve 20...Detention area 21...Balloon section 22...Drive pressure supply line (line) 23...Indwelling drive unit 24...Drive pressure supply outer pipe (pipe) 30...Inlet section 31...Inlet tube 32...Inlet pipe (pipe) 33...Supply port 33s…Small supply port 40...Outlet section 41...Outlet tube 42...Outlet pipe (pipe) 43…Discharge port 50...Outlet storage section 51...Balloon section 52...Drive pressure supply line 53...Outlet placement drive unit 54...Outer driving pressure supply line 55...Flange 59...Stopper part 60...Measuring part 61, 62...Pressure sensors 63,64...Flow sensor 67...Blood oxygen concentration sensor 68...Blood carbon dioxide concentration sensor 70...Liquid circulation gas exchange section 71...Filter section 72...Temperature adjustment section (heat exchange section) 73...Gas-liquid separation section 74...Artificial lung department 75...Pump 76...Control valve 90...Control unit

Claims

1. 1. An intestinal ventilation device for administering oxygenated liquid into the intestine, comprising: Promotion Department and a retention section for retaining the oxygenated liquid in a predetermined region within the intestine; an inlet portion for supplying the oxygenated liquid into the intestine; an outlet for discharging the oxygenated liquid from the intestine; a liquid circulation / gas exchange unit that supplies the oxygenated liquid to the inlet unit and circulates the discharged liquid from the outlet unit by gas exchange; a propulsion drive unit that propels and drives the propulsion unit; a placement drive unit that drives the placement unit; Equipped with the propulsion section, the retention section, the inlet section, and the outlet section constitute an intestinal insertion section to be inserted into the intestine. An intestinal ventilation device characterized by:

2. The liquid circulation gas exchange unit includes a filter unit that filters the discharged liquid.

2. The intestinal ventilation device according to claim 1.

3. the retention portion has a balloon portion, The placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit.

2. The intestinal ventilation device according to claim 1.

4. the inlet portion has an inlet tube connected to a proximal end of the intestinal insertion portion, the inlet tube has a supply port for supplying the oxygenated liquid at a distal end thereof or at a position closer to a proximal end of the intestinal insertion section than the distal end thereof; 2. The intestinal ventilation device according to claim 1.

5. The propelling portion is located at the tip of the enteral insertion portion.

2. The intestinal ventilation device according to claim 1.

6. the retention section is disposed closer to the proximal end of the intestinal insertion section than the propulsion section.

2. The intestinal ventilation device according to claim 1.

7. a distal end of the inlet section is disposed closer to the proximal end of the intestinal insertion section than the indwelling section; 2. The intestinal ventilation device according to claim 1.

8. The outlet portion has an outlet for discharging the oxygenated liquid from the intestine, the outlet being disposed at a proximal end of the intestinal insertion portion.

2. The intestinal ventilation device according to claim 1.

9. an outlet retention portion that retains the outlet portion near the anus; an outlet indwelling drive unit that drives the outlet indwelling unit; Equipped with 2. The intestinal ventilation device according to claim 1.

10. the outlet retention portion has a balloon portion, The outlet placement drive unit is capable of supplying a fluid to the balloon unit to expand the diameter of the balloon unit.

10. The intestinal ventilation device of claim 9.

11. The propulsion unit includes: a tube assembly formed by spirally winding at least three flexible tubes that are expandable and contractible when pressure is applied to the inside of the tubes and sealing the ends of the tubes; the proximal ends of the tubes in the tube assembly are each connected to the propulsion drive; the propulsion drive unit is a fluid pressure source; (1) applying pressure from the propulsion drive to one of the at least three tubes; (2) depressurizing the tube and pressurizing another tube; (3) The above steps (1) and (2) are carried out sequentially for all tubes without overlapping until the first tube is reached. (4) By repeating the steps (1) to (3) above, the tube assembly is deformed into a spiral shape, and the spirally transformed tube assembly rotates around the body axis, which is the center of at least three of the tubes, and the pressurized tubes of the spirally transformed tube assembly come into close contact with the inner wall of the intestine, while the entire tube assembly moves along the intestine while tracing a spiral trajectory.

2. The intestinal ventilation device according to claim 1.

12. the propelling sections are each connected to the propelling drive section by a conduit that is less expandable than the tube at least from the proximal end of the tube assembly to the proximal end of the enteral insertion section; 12. The intestinal ventilation device of claim 11.

13. the intestinal insertion portion is provided with an X-ray fluoroscopy marker that can be distinguished under X-ray fluoroscopy; 2. The intestinal ventilation device according to claim 1.

14. the liquid circulation gas exchange unit, the propulsion drive unit, and the placement drive unit are connected to a proximal end of the intestinal insertion unit.

2. The intestinal ventilation device according to claim 1.

15. A measuring unit for measuring the pressure of the oxygenated liquid supplied into the intestine.

2. The intestinal ventilation device according to claim 1.

16. The liquid circulation gas exchange unit includes at least a measuring unit for measuring the flow rate of the oxygenated liquid supplied to the inlet unit; a measuring unit for measuring the flow rate of the discharged liquid discharged from the outlet unit; The present invention provides one of the following:

2. The intestinal ventilation device according to claim 1.

17. A control unit; a measuring unit that measures the pressure and flow rate of the oxygenated liquid supplied into the intestine; Equipped with the control unit controls the liquid circulation / gas exchange unit so that the pressure of the oxygenated liquid to be supplied into the intestine and the flow rate of the oxygenated liquid do not exceed predetermined values ​​based on the measurement value of the measurement unit.

2. The intestinal ventilation device according to claim 1.

18. The measurement unit has a blood oxygen concentration sensor that measures the blood oxygen concentration of the treatment recipient, and a sensor that measures the blood carbon dioxide concentration of the treatment recipient, the control unit controls the liquid circulation / gas exchange unit based on values ​​of blood oxygen saturation and blood carbon dioxide concentration to adjust the pressure and flow rate of the oxygenated liquid to be supplied into the intestine.

18. The intestinal ventilation device of claim 17.

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