Skin external preparation

Abstract

To provide a skin external preparation containing hydrolyzed gardenia extract that allows suppression of discoloration of the hydrolyzed gardenia extract and enables application to a broad range of formulations.SOLUTION: A skin external preparation contains (A) hydrolyzed gardenia extract and (B) nicotinamide. By containing (A) hydrolyzed gardenia extract and (B) nicotinamide, the skin external preparation prevents discoloration of the hydrolyzed gardenia extract while enabling application to a broad range of formulations.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] Natural pigments derived from animals, plants, and microorganisms not only impart color to formulations but also change the color of skin and hair to a desired shade, and thus have been used in many topical skin preparations. Some natural pigments not only have skin color-imparting effects, but also have skin care effects, such as moisturizing the skin. For example, hydrolyzed gardenia extract obtained from gardenia is cited. It has been reported that when combined with a moisturizer, it is effective in moisturizing, improving rough skin, and preventing skin aging, and that when combined with a whitening agent, it enhances the whitening effect (Patent Documents 1 and 2).

[0003] On the other hand, many natural pigments, including hydrolyzed gardenia extract, have poor light and heat resistance and tend to fade over time, resulting in reduced skin benefits. Therefore, when incorporating natural pigments into topical skin preparations, measures to ensure quality are necessary. Measures to ensure quality include, for example, the use of an anti-fading agent for gardenia blue pigment and / or safflower yellow pigment containing chlorogenic acids as active ingredients (Patent Document 3), and containing 20% ​​by weight or more of a natural pigment, a hydrophilic surfactant, and at least one polyhydric alcohol having at least three or more hydroxyl groups in the molecule, with a substantial water content of 10% by weight or less (Patent Document 4). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2000-119155 [Patent Document 2] Japanese Patent Application Laid-Open No. 2000-119156 [Patent Document 3] Japanese Patent Application Publication No. 5-032909 [Patent Document 4] Japanese Patent Application Laid-Open No. 2007-077112 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the above-mentioned measures have limitations on the amount added and applications due to the unique color or fragrance caused by the anti-fading agent, and the range of formulations is limited if the water content is 10% by mass or less, making it difficult to apply to a wide range of formulations. For these reasons, a new method for preventing or suppressing the fading of hydrolyzed gardenia extract that is not limited by the amount added or applications and can be applied to a wide range of formulations is needed.

[0006] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an external skin preparation containing hydrolyzed gardenia extract that can be applied to a wide range of formulations while preventing discoloration of the hydrolyzed gardenia extract. [Means for solving the problem]

[0007] As a result of intensive research to solve the above problems, the present inventors discovered that the incorporation of nicotinamide can inhibit the discoloration of hydrolyzed gardenia extract. Therefore, by combining hydrolyzed gardenia extract and nicotinamide, they discovered an external skin preparation that can achieve a water content of 10% by mass or more without impairing the appearance of the external skin preparation or its effects on the skin over time, without imposing restrictions on the amount added or application, and completed the present invention.

[0008] The external skin preparation according to the present invention contains the following component (A) and component (B): (A) Hydrolyzed Gardenia Extract (B) Nicotinamide

[0009] With this constitution, the external skin preparation of the present invention can be applied to a wide range of preparations while preventing discoloration of the hydrolyzed gardenia extract.

[0010] The topical skin preparation according to the present invention may have an amount of component (A) of 0.0001 to 3% by mass relative to the total mass of the topical skin preparation, an amount of component (B) of 0.01 to 10% by mass relative to the total mass of the topical skin preparation, and a ratio (A / B) of the amount of component (A) to the amount of component (B) of 5.0 or less.

[0011] With this constitution, the external skin preparation of the present invention suppresses stickiness and nicotinamide precipitation, and further improves the anti-fading effect of the hydrolyzed gardenia extract. [Effects of the Invention]

[0012] According to the present invention, it is possible to provide an external skin preparation that can be applied to a wide range of formulations while preventing discoloration of hydrolyzed gardenia extract. DETAILED DESCRIPTION OF THE INVENTION

[0013] The following describes in detail embodiments of the present invention, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims. Embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, in this specification, unless otherwise specified, "A to B" representing a numerical range means "greater than or equal to A and less than or equal to B."

[0014] The topical skin preparation according to this embodiment contains (A) hydrolyzed gardenia extract and (B) nicotinamide.

[0015] <(A) Hydrolyzed Gardenia Extract> The component (A) used in the topical skin preparation according to this embodiment is a hydrolyzed gardenia extract. The hydrolyzed gardenia extract is obtained by hydrolyzing an extract obtained from the fruit of gardenia, a plant of the Rubiaceae family. Methods for hydrolysis include, but are not limited to, the use of acids and enzymes.

[0016] These ingredients are available as commercially available cosmetic ingredients, such as "Gardenia Green Color PG1" and "Gardenia Blue Color 1250P" (both from Glico Nutrition Foods Co., Ltd.) and "Gardenia Blue" (from Koei Kogyo Co., Ltd.).

[0017] The inclusion of hydrolyzed gardenia extract as component (A) in the topical skin preparation according to this embodiment reduces skin dullness, contributes to improving skin clarity, and provides moisture to the skin. The amount of component (A) is not particularly limited, but is preferably 0.0001% by mass or more and 3% by mass or less of the total mass of the topical skin preparation. A content of component (A) of 0.0001% by mass or more sufficiently reduces dullness and achieves a sufficient effect of improving skin clarity. On the other hand, a content of component (A) of 3% by mass or less reduces stickiness and improves the complexion of the skin. From the viewpoint of usability, the amount of component (A) is more preferably 0.0005% by mass or more and 1% by mass or less, and even more preferably 0.001% by mass or more and 0.5% by mass or less.

[0018] Hydrolyzed gardenia extract alone provides moisturizing effects, but adding hydrolyzed gardenia extract to ingredient (B), which will be described later, synergistically improves the moisturizing effects.

[0019] <(B) Nicotinamide> The component (B) used in the topical skin preparation according to this embodiment is nicotinamide. Nicotinamide is a water-soluble vitamin belonging to the vitamin B group, and is also called niacinamide. Any nicotinamide commonly used in pharmaceuticals, quasi-drugs, and cosmetics can be used without particular limitation, and these may be natural or synthetic. Nicotinamide is known to have anti-wrinkle effects, promoting blood circulation, improving rough skin, inhibiting melanin production, and whitening effects.

[0020] Nicotinamide is available as a commercially available cosmetic raw material. Examples of commercially available products include "Niacinamide USP PC (manufactured by Arcsada Japan)" and "Nicotinamide (manufactured by DSM)."

[0021] The inclusion of nicotinamide as component (B) in the topical skin preparation according to this embodiment can inhibit discoloration of hydrolyzed gardenia extract. The amount of component (B) contained in the topical skin preparation according to this embodiment is preferably 0.01% by mass or more and 10% by mass or less of the total mass of the topical skin preparation. A content of component (B) of 0.01% by mass or more provides a sufficient effect of inhibiting discoloration of hydrolyzed gardenia extract, while a content of component (B) of 10% by mass or less can inhibit stickiness and precipitation of nicotinamide over time. From the viewpoint of usability, the amount of component (B) is more preferably 0.03% by mass or more and 3% by mass or less, and even more preferably 0.05% by mass or more and 1% by mass or less.

[0022] Nicotinamide alone provides moisturizing effects, but adding nicotinamide to component (A) synergistically improves the moisturizing effects.

[0023] Furthermore, in the topical skin preparation according to this embodiment, the ratio (A / B) of the amount of component (A) to the amount of component (B) is preferably 5.0 or less, more preferably 1.0 or less, and even more preferably 0.5 or less. When this ratio is 5.0 or less, the effect of component (B) in inhibiting fading of component (A) can be fully exerted, and the effect of maintaining skin transparency over time can be maintained.

[0024] The topical skin preparation according to this embodiment contains nicotinamide (component (B)), which inhibits discoloration of the hydrolyzed gardenia extract (component (A)). Furthermore, there is no effect on color or fragrance due to nicotinamide, and there are no restrictions on the amount added or application. Furthermore, there is no restriction on the water content of the topical skin preparation. Therefore, the topical skin preparation according to this embodiment can be applied to a wide range of formulations.

[0025] <Other ingredients> In addition to the above-mentioned components, the topical skin preparation according to this embodiment may contain other components, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, polymeric compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, and the like, as appropriate, provided that the purpose of the present invention is not impaired.

[0026] Furthermore, the topical skin preparation of the present invention can be appropriately blended with physiologically active ingredients within the scope of the present invention. A physiologically active substance is a substance that imparts some physiological activity to the skin when applied to the skin, and examples thereof include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, and the like. Examples of such agents include stimulating agents, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation soothing agents, analgesics, and cell activators.

[0027] The topical skin preparation according to this embodiment can be manufactured according to a conventional method. The topical skin preparation according to this embodiment can be used, for example, as a lotion, emulsion, cream, gel, serum, sheet mask, makeup, body lotion, body gel, body cream, makeup base, etc. The dosage form can also be selected arbitrarily depending on the purpose. Examples include liquid, cream, gel, emulsion, sheet, stick, and aerosol forms. The topical skin preparation according to this embodiment is not limited to general topical preparations, but also includes quasi-drugs, designated quasi-drugs, topical medicines, etc. [Example]

[0028] The present invention will now be described in detail with reference to examples, but is not limited thereto. Prior to the examples, the test and evaluation methods employed in each example will be described.

[0029] 1. Skin clarity evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. An appropriate amount of each skin preparation from the Examples and Comparative Examples was then applied, and a sensory evaluation of the skin translucency after use was carried out using the following scoring system. The evaluation criteria were based on the average of the scores for translucency from the 10 panelists, and the results were classified as follows: <Transparency rating and details> 5 points: After use, the skin feels very clear. 4 points: After use, the skin feels slightly clearer. 3 points: After use, I feel that my skin is slightly clearer. 2 points: After use, I feel that my skin is slightly clearer. 1 point: My skin doesn't feel any clearer after using it. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0030] 2. Evaluation test of changes in skin clarity over time The above-mentioned "skin transparency evaluation test" was also performed using the same test system and evaluation method on the topical skin preparations of the Examples and Comparative Examples that had been stored at 45°C for one month, and the amount of change in the sensory evaluation over time was calculated. The amount of change in the skin transparency evaluation was calculated using the following formula. <Changes in skin clarity evaluation> Change in skin transparency evaluation = {Scores of the topical skin preparations of Examples and Comparative Examples in the above "Skin Transparency Evaluation Test"} - {Scores of the topical skin preparations of Examples and Comparative Examples stored at 45°C for 1 month}

[0031] 3. Skin moisture evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment at 25°C and 50% relative humidity. An appropriate amount of each skin topical preparation from the Examples and Comparative Examples was then applied, and after acclimatization for 20 minutes again in an environment at 25°C and 50% relative humidity, the stratum corneum moisture content (conductance value) was measured using a Corneometer (MPA580, Courage+Khazaka). The moisturizing effect was evaluated by calculating the moisturizing effect (%) using the following formula, and the average value of the 10 panelists was calculated, based on the following criteria: <Skin moisturizing effect rating> Moisture effect (%) = (skin keratin moisture content after application / keratin moisture content before application) x 100 (Evaluation criteria for skin moisturizing effect) ⊚: Moisturizing effect (%) was 150% or more. ○: Moisturizing effect (%) was 120% or more and less than 150%. △: Moisturizing effect (%) was 100% or more but less than 120%. ×: Moisturizing effect (%) was less than 100%.

[0032] 4. Evaluation test of color difference change in the appearance of topical skin preparations over time The topical skin preparations of the present invention and comparative examples were measured using a colorimeter (ZE 6000, manufactured by Nippon Denshoku Industries Co., Ltd.) and the b* values ​​were quantified. The values ​​were quantified for the products immediately after production and for the products stored at 45°C for one month, and the color difference change Δb* was calculated using the following formula. <Score for redness reduction effect> Δb* = (b* value of topical skin preparations of Examples and Comparative Examples stored at 45°C for 1 month / b* value of topical skin preparations of Examples and Comparative Examples immediately after production) × 100 (Evaluation criteria for color difference change) ⊚: The change in color difference was less than 15. ◯: The amount of change in color difference was 15 or more and less than 30. △: The amount of change in color difference was 30 or more and less than 45. ×: The amount of change in color difference was 45 or more.

[0033] 5. Non-stickiness evaluation test Ten expert panelists washed their forearms with lukewarm water and then allowed them to acclimate for 20 minutes in an environment at 25°C and 50% relative humidity. Then, an appropriate amount of each skin preparation from the Examples and Comparative Examples was applied, and a sensory evaluation was conducted on the stickiness of the skin during and after use using the following scoring system. The evaluation criteria were based on the average of the scores of the 10 panelists regarding the lack of stickiness, and the results were classified as follows: <Scores and details regarding non-stickiness> 5 points: Skin does not feel sticky during or after use. 4 points: Skin feels slightly sticky during and after use. 3 points: Skin feels slightly sticky during and after use. 2 points: Skin feels sticky during and after use. 1 point: The skin feels very sticky during and after use, which is uncomfortable. (Evaluation criteria for non-stickiness) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)

[0034] <Examples 1 to 11 and Comparative Examples 1 and 2> The topical skin preparations having the formulations of Examples 1 to 11 and Comparative Examples 1 and 2 shown in Tables 1 and 2 were prepared by conventional methods and evaluated by the respective test methods.

[0035] [Table 1]

[0036] [Table 2]

[0037] As is clear from Tables 1 and 2, all of the topical skin preparations of the Examples had excellent performance. In particular, the change in color difference in appearance over time was small, and there was no fading of the hydrolyzed gardenia extract over time. It was also shown that the water content was sufficient and that the product could be applied to a wide range of preparations. On the other hand, the comparative example was inferior in any of the following aspects: skin transparency, change in skin transparency evaluation over time, skin moisture, change in color difference in appearance over time, non-stickiness, and stability, and the object of the present invention could not be achieved.

[0038] Other examples are listed below as formulation examples to demonstrate that the topical skin preparation of the present invention can be applied to a wide range of formulations. The topical skin preparations of these formulation examples were also examined for the above-mentioned skin transparency, changes in skin transparency evaluation over time, skin moisture, changes in color difference in appearance over time, non-stickiness, and stability, and were found to have excellent properties in all respects.

[0039] Formulation example 1 (beauty serum) (mass%) (1) Hydrolyzed Gardenia Extract 3.0% (2) Angelica keiskei leaf / stem extract 0.4% (3) Niacinamide 0.02% (4) Glucosylceramide 0.01% (5) Retinol palmitate 0.1% (6) Ascorbic acid 2-glucoside 3.0% (7) L-Ascorbic acid sulfate disodium 0.7% (8) Loquat Fruit Extract 0.4% (9) Rose water 2.0% (10) Job's Tears Seed Extract 0.01% (11) Agar 0.1% (12) Diphenylsiloxyphenyl trimethicone 0.3% (13) Trimethylsiloxyphenyl dimethicone 0.2% (14) Phenyl trimethicone 0.01% (15) Yuzu Fruit Extract 0.4% (16) PEG-20 0.07% (17) PEG-400 0.5% (18) Polyglycerin-6 0.1% (19) Methylgluceth-20 5.0% (20) Glycerin 10.0% (21) Dipropylene glycol 3.0% (22) 1,3-butylene glycol 0.5% (23) EDTA-2Na 0.01% (24) Xanthan gum 0.01% (25) Carboxyvinyl polymer 0.2% (26) Alkyl-modified carboxyvinyl polymer 0.01% (27) Trisodium Hydroxyethylethylenediaminetriacetate 0.001% (28) PPG-13 decyltetradeceth-24 0.5% (29) Polysorbate 20 0.1% (30) Polyglyceryl-10 myristate 1.5% (31) Citric acid 0.02% (32) Sodium citrate 0.004% (33)Fragrance 0.07% (34) Phenoxyethanol 0.1% (35) Methylparaben 0.5% (36) Purified water remainder

[0040] (Production method) (12) to (36) were heated to 80°C and dissolved uniformly. After cooling to room temperature, (1) to (11) were added and dissolved uniformly, and the mixture was filled into a container to prepare a beauty serum.

[0041] Formulation example 2 (sheet mask) (mass%) (1) Hydrolyzed Gardenia Extract 0.2% (2) Niacinamide 2.0% (3) Water-soluble collagen 1.0% (4) Glucosyltrehalose 0.01% (5) Betaine 0.01% (6) Royal jelly extract 0.02% (7) Ascorbic acid 2-glucoside 0.1% (8) Sage Leaf Extract 0.6% (9) Lemon Fruit Extract 0.5% (10) α-glucan 1.5% (11) PEG-250 2.5% (12) Sodium polyacrylate 1.0% (13) Dipropylene glycol 3.0% (14) Copper chlorophyll 0.01% (15) Alkyl-modified carboxyvinyl polymer 0.15% (16) PEG-10 glyceryl triisostearate 0.1% (17) (PCA / Isostearic acid) PEG-40 Hydrogenated Castor Oil 0.1% (18) PEG-60 hydrogenated castor oil 0.1% (19) Monopotassium phosphate 0.09% (20) Disodium phosphate 0.01% (21) Methylparaben 0.005% (22) Cyclohexylglycerin 0.5% (23) Squalane 0.1% (24) PEG-11 methyl ether dimethicone 0.05% (25) Ethylhexyl palmitate 0.1% (26) Diphenylsiloxyphenyl trimethicone 0.5% (27) Purified water remainder

[0042] (Production method) (1) to (22) and (27) were heated to 80°C and stirred to dissolve uniformly (Liquid A). (23) to (26) were heated to 80°C and stirred to disperse uniformly (Liquid B). Liquid B was added to Liquid A and dispersed uniformly using a homomixer, and then cooled to 30°C to prepare a beauty serum. The prepared beauty serum was then impregnated into a nonwoven fabric sheet to prepare a sheet mask.

[0043] Formulation example 3 (whitening makeup base cream) (mass%) (1) Gardenia blue liquid 0.5% (2) Nicotinamide 0.9% (3) Japanese Knotweed Root Extract 1.2% (4) Peony extract 0.1% (5) Glycine 8.0% (6) Scutellaria root extract 0.75% (7) D-Pantothenyl alcohol 0.05% (8) Chamomile flower extract 0.0003% (9) Gardenia fruit extract 2.5% (10) Licorice Root Extract 5.0% (11) Althea Root Extract 0.0007% (12) Aloe vera juice 0.85% (13) Fennel Fruit Extract 1.0% (14) Turmeric extract 0.02% (15) Coenzyme Q10 0.001% (16) Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.75% (17) Dipotassium glycyrrhizinate 0.2% (18) Ascorbic acid 2-glucoside 2.0% (19) Tranexamic acid 3.0% (20) Sodium N-stearoyl-L-glutamate 0.5% (21) Sorbitan monoisostearate 0.1% (22) PEG-10 glyceryl triisostearate 0.2% (23) PEG-60 hydrogenated castor oil 0.9% (24) Carboxyvinyl polymer 0.1% (25) Xanthan gum 0.01% (26) Hydrophobized hydroxypropyl methylcellulose 0.01% (27) Potassium hydroxide 0.02% (28) L-Arginine 0.01% (29) Citric acid 0.01% (30) Dipotassium phosphate 0.04% (31)Tartaric acid 0.01% (32) Triethanolamine 0.02% (33) Ethylparaben 0.05% (34) Methylparaben 0.05% (35) Phenoxyethanol 0.5% (36) 3-O-Ethyl ascorbic acid 0.01% (37) Retinol palmitate 0.01% (38) dl-α-Tocopherol Nicotinate 0.05% (39) Mineral oil 7.0% (40) Octyldodecyl myristate 2.0% (41) Squalane 1.0% (42) Tri(caprylic / capric / myristic / stearic acid) Glyceryl Glyceryl 0.5% (43) Zinc oxide 0.1% (44) Di(phytosteryl / isostearyl / dilinoleate) Cetyl / Stearyl / Behenyl) 0.3% (45) White Beeswax 1.2% (46) Sodium cetyl sulfate 0.5% (47) Phenyl trimethicone 0.3% (48) Methylphenylpolysiloxane 1.0% (49) Diphenyl trimethicone 0.1% (50) Purified water remainder

[0044] (Production method) (20) to (35) and a portion of (50) were heated to approximately 80°C and stirred to dissolve uniformly (liquid A). (36) to (49) were heated to approximately 80°C and stirred to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed using a homomixer. The mixture was then cooled, and a solution of (1) to (19) in the remainder of (50) at 40°C was added and further dissolved uniformly. The mixture was again cooled to 30°C to prepare a whitening makeup base cream.

[0045] Formulation example 4 (gel cream) (mass%) (1) Hydrolyzed Gardenia Extract 0.5% (2) Niacinamide 0.2% (3) White clover extract 0.1% (4) Tranexamic acid 2.0% (5) Aminobutyric acid 0.5% (6) Guaiazulene 0.01% (7) Carambola Fruit Extract 0.8% (8) Glycereth-26 0.5% (9) Arginine 0.1% (10) Edetate disodium 0.01% (11) PEG-20 0.01% (12) Behenyl alcohol 1.0% (13) Sodium stearoyl glutamate 1.2% (14) Carboxyvinyl polymer 0.2% (15) (Acrylates / C10-30 alkyl acrylate) Crosspolymer 0.1% (16)HEDTA-3Na 0.005% (17) Citric acid 0.01% (18) Potassium hydroxide 0.22% (19) Caramel 0.2% (20) 1,3-butylene glycol 5.0% (21) Glyceryl monostearate 3.0% (22) Octyldodecyl myristate 0.5% (23) Methylpolysiloxane (6CS) 1.5% (24) Diphenylsiloxyphenyl trimethicone 0.05% (25) Beeswax 1.0% (26) Ceramide III 0.1% (27) Polyglyceryl-10 myristate 0.5% (28) Sorbitan isostearate 0.2% (29) Pure water remainder

[0046] Manufacturing method) (9) to (20) and (29) were heated to 80°C and uniformly dissolved (liquid A). (21) to (28) were uniformly dissolved and then heated to 80°C (liquid B). Liquid A was added to liquid B, and the mixture was dispersed using a homomixer. The mixture was then cooled to room temperature to prepare a gel cream.

[0047] Formulation example 5 (wrinkle concealing cream) (mass%) (1) Hydrolyzed Gardenia Extract 1.2% (2) Niacinamide 4.0% (3) Hot spring water 25.0% (4) Hydrolyzed collagen 0.05% (5) Lactobacillus / Pear Juice Fermentation Filtrate 0.5% (6) Silk hydrolyzate 0.3% (7) Rosa multiflora fruit extract 0.0008% (8) Rosemary leaf extract 0.09% (9) Brown algae extract 0.0001% (10) Red algae extract 0.45% (11) Green algae extract 0.5% (12) Saccharomyces / Rice Fermentation Liquid 0.9% (13) Ethanol 15.0% (14) Polyoxyethylene (2) alkyl (12-15) phosphate 0.5% (15) Polyoxyethylene (2) oleyl ether 0.5% (16) PEG-60 hydrogenated castor oil 0.5% (17) Polyvinylpyrrolidone 0.1% (18) Carboxyvinyl polymer 0.3% (19) Potassium hydroxide 0.15% (20) Edetate disodium 0.05% (21)Fragrance 0.1% (22) Phenoxyethanol 0.2% (23) Liquid paraffin 5.0% (24) Methylpolysiloxane (100cs) 1.0% (25) Vaseline 1.0% (26) Diphenyl trimethicone 1.5% (27) Diphenylsiloxyphenyl trimethicone 1.0% (28) Purified water remainder

[0048] (Production method) (14) to (22) are added to (28) and heated to 70°C to dissolve uniformly (liquid A). (23) to (27) are heated to 60°C to disperse uniformly, and added to liquid A and dispersed using a homomixer. Next, (1) to (13) are added and stirred, and the mixture is filled into a tube container to prepare a wrinkle concealing cream.

[0049] Formulation example 6 (skin texture improving serum) (mass %) (1) Hydrolyzed Gardenia Extract 1.3% (2) Niacinamide 7.0% (3) PEG-75 1.0% (4) Birch bark extract 0.7% (5) Tea leaf extract 0.01% (6) Hydrolyzed elastin 0.5% (7) Orange flower water 0.3% (8) PEG-20 0.2% (9) English: ... (10) Elderberry Extract 0.5% (11) Parietaria extract 0.75% (12) Arnica flower extract 0.3% (13) Soybean Seed Extract 0.1% (14) Grape Leaf Extract 0.1% (15) Hypericum perforatum flower / leaf / stem extract 0.07% (16) Hamamelis leaf extract 0.1% (17) Horse Chestnut Leaf Extract 0.1% (18) Fuyubotaiju extract 0.004% (19) Calendula officinalis flower extract 0.25% (20) Cornflower flower extract 0.1% (21) Roman chamomile flower extract 0.1% (22) Peach Leaf Extract 0.005% (23) Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.01% (24) (Sodium acrylate / sodium acryloyldimethyltaurate) Copolymer 0.4% (25) Polyquaternium-52 0.7% (26) POE(60) hydrogenated castor oil 0.5% (27) 1,3-butylene glycol 8.0% (28) Glycerin 10.0% (29) Methylgluceth-20 1.0% (30) Sorbitol 1.0% (31) Maltitol 1.0% (32) Diisopropanolamine 0.05% (33) Potassium hydroxide 0.05% (34) Carboxyvinyl polymer 0.1% (35) Alkyl-modified carboxyvinyl polymer 0.12% (36) Xanthan gum 0.1% (37) Edetate disodium 0.01% (38) Sodium pyrosulfite 0.005% (39) Octyldodecyl myristate 3.0% (40) Cholesterol 0.5% (41) Diphenylsiloxyphenyl trimethicone 1.2% (42) Purified water remainder

[0050] (Production method) (1) to (38) and (42) were uniformly dissolved at 80°C, and (39) to (41) were uniformly dispersed at 80°C. The mixture was added to the solution, dispersed using a homomixer, and then cooled to prepare a texture-improving serum.

[0051] Formulation example 7 (Sunscreen) (mass%) (1) Hydrolyzed Gardenia Extract 0.001% (2) Niacinamide 0.2% (3) Sodium hyaluronate 0.001% (4) Ethanol 15.0% (5) Dipropylene glycol 2.0% (6) Ethylhexyl methoxycinnamate 2.0% (7) Diethylaminohydroxybenzoylhexyl benzoate 1.0% (8) Bis-ethylhexyloxyphenol Methoxyphenyltriazine 3.0% (9) t-Butyl methoxydibenzoylmethane 3.0% (10) Starch octenyl succinate aluminum 0.2% (11) POE·POP modified dimethylpolysiloxane 1.0% (12) Octyldodecyl myristate 5.0% (13) Isononyl isononanoate 1.0% (14) Diphenylsiloxyphenyl trimethicone 8.0% (15) Methylcyclopolysiloxane 1.0% (16) Dimethylpolysiloxane 1.0% (17) Hydrogenated lecithin 0.8% (18) Phytosterol 0.8% (19) DL-α-Tocopherol Acetate 0.1% (20) Scutellaria root extract 0.5% (21) Lithospermum Root Extract 0.005% (22) Angelica acutiloba root extract 0.002% (23) Royal Jelly Extract 0.9% (24) Glucosylceramide 0.01% (25) Aloe vera leaf extract 0.01% (26) Sodium chondroitin sulfate 0.001% (27) Ceramide NG 0.003% (28) Acetylglucosamine 0.2% (29) Bentonite 0.5% (30) Disteardimonium hectorite 0.1% (31) Silica-coated zinc oxide 5.0% (32) Purified water remainder

[0052] (Production method) (1) to (3) are added to (31) heated to 80°C and dissolved (Liquid A). (5), (16) to (32) are added and heated to 80°C to disperse uniformly (Liquid B). (6) to (15) are heated to 70°C to dissolve uniformly (Liquid C). Liquids B and C are added to Liquid A in this order, mixed uniformly using a homomixer, and then cooled to 50°C. (4) and (10) are added to this, mixed uniformly using a homomixer, and then cooled to obtain the sunscreen.

Claims

1. A topical skin preparation containing the following components (A) and (B): (A) Hydrolyzed Gardenia Extract (B) Nicotinamide

2. The amount of component (A) is 0.0001 to 3% by mass relative to the total mass of the topical skin preparation, The amount of component (B) is 0.01 to 10% by mass relative to the total mass of the topical skin preparation, 2. The external skin preparation according to claim 1, wherein the ratio (A / B) of the amount of component (A) to the amount of component (B) is 5.0 or less.

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