Stinging irritation inhibitor, cosmetic, and stinging irritation inhibition method

Abstract

To provide a stinging irritation inhibitor, a cosmetic, and a method for inhibiting stinging irritation, which are capable of inhibiting stinging irritation induced by a stinging irritation-inducing component.SOLUTION: A stinging irritation inhibitor contains nicotinamide as an active ingredient and inhibits stinging irritation caused by a stinging irritation-inducing component. A cosmetic contains nicotinamide and a stinging irritation-inducing component and inhibits stinging irritation. A stinging irritation inhibition method inhibits stinging irritation caused by a stinging irritation-inducing component by means of nicotinamide.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an agent for suppressing stinging irritation, a cosmetic, and a method for suppressing stinging irritation. [Background technology]

[0002] Cosmetics contain a variety of ingredients, including moisturizing ingredients, beauty ingredients, and cosmetic quality preserving ingredients. It is known that some of these ingredients can cause skin irritation, such as tingling, burning, burning, or a cold sensation, when applied to the skin. For example, ingredients such as parabens, phenoxyethanol, and alkanediols, which are used as quality preserving ingredients, and some vitamins, which are used as beauty ingredients, are known to cause skin irritation. This irritation is experienced as a sensory irritation rather than as a serious skin symptom such as redness, peeling, or rough skin. Because it is not a serious skin symptom, little attention has been paid to treatments or methods other than discontinuing the use of the relevant skin care product. However, for consumers, the presence or absence of irritation is extremely important when using cosmetics, as it can cause significant discomfort in daily skin care.

[0003] However, quality-preserving ingredients and beauty ingredients are considered essential ingredients in cosmetics, and therefore, rather than simply studying cosmetics that do not contain ingredients that cause irritation, there is a demand for cosmetics that contain essential ingredients but suppress irritation to the skin during use.

[0004] Against this background, efforts have been made to suppress the irritation or irritation caused by quality-preserving ingredients and cosmetic ingredients. Examples of suppressing irritation or irritation include suppressing the irritation caused by fragrances with cyclodextrin (see Patent Document 1), suppressing the irritation caused by anionic surfactants with polyethylene glycol (see Patent Document 2), suppressing the irritation caused by ultraviolet absorbers with hydroquinone glycosides (see Patent Document 3), and suppressing the irritation caused by pigments with hydroquinone glycosides (see Patent Document 4). Other examples of suppressing irritation include using polyoxyethylene cholesterol or verapamil (see Patent Document 5), suppressing the irritation caused by cleansers containing sea mud and charcoal (see Patent Document 6), using foam in an aerosol formulation (see Patent Document 7), and suppressing TRPA1 activity (see Patent Document 8). Other examples of cleansers that do not use irritating ingredients or that do not allow them to reach the skin include a combination of a fatty acid ester of polyglycerin with an HLB of 10 or higher, a skin repair material, and phenoxyethanol (see Patent Document 9), a cleanser that reduces irritation by not using parabens (see Patent Document 10), and a cleanser that reduces irritation by improving the skin barrier function (see Patent Document 11).

[0005] The cosmetics described in Patent Documents 1 to 11 refer to the alleviation of various irritations, but the substances that cause irritation are diverse, and no invention has been developed that can comprehensively suppress them. Furthermore, the components that cause irritation, which is a sensory stimulus different from irritation that causes damage to the skin, such as inflammation, are even more diverse, including unknown components, so there is a need for other components that can alleviate irritation. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Publication No. 59-010323 [Patent Document 2] Japanese Patent Application Publication No. 54-145225 [Patent Document 3] Japanese Patent Application Publication No. 61-200906 [Patent Document 4] Japanese Patent Application Publication No. 61-210007 [Patent Document 5] Japanese Patent Application Publication No. 63-280006 [Patent Document 6] Japanese Patent Application Laid-Open No. 2001-233722 [Patent Document 7] Japanese Patent Application Laid-Open No. 2003-292431 [Patent Document 8] Japanese Patent Application Laid-Open No. 2013-256473 [Patent Document 9] Japanese Patent Application Laid-Open No. 2004-196666 [Patent Document 10] Japanese Patent Application Laid-Open No. 2007-161641 [Patent Document 11] Japanese Patent Application Laid-Open No. 2007-210892 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention has been made in view of the above problems, and an object of the present invention is to provide a stinging irritation inhibitor, a cosmetic, and a method for suppressing stinging irritation that suppress the stinging irritation caused by stinging-inducing components. [Means for solving the problem]

[0008] As a result of further intensive research to achieve the above object, the present inventors discovered that nicotinamide has the effect of reducing the unpleasant stinging sensation caused by stinging-inducing components, and thus completed the present invention.

[0009] The present invention is as follows. [1] A stinging stimulus inhibitor containing nicotinamide as an active ingredient, which suppresses the stinging stimulus caused by a stinging stimulus-inducing component. [2] The stinging stimulus suppressant according to [1] above, wherein the stinging stimulus inducing component is one or more selected from parabens, phenoxyethanol, alkyldiols having 6 or more carbon atoms, vitamin B6, and vitamin B12. [3] A cosmetic that suppresses stinging irritation, containing nicotinamide and a component that induces stinging irritation. [4] The cosmetic preparation according to [3] above, wherein the stinging stimulation-inducing component is one or more selected from parabens, phenoxyethanol, alkanediols having six or more carbon atoms, vitamin B6, and vitamin B12. [5] A method for suppressing stinging stimulation, in which stinging stimulation caused by a stinging stimulation-inducing component is suppressed by nicotinamide. [6] The method for suppressing stinging irritation described in [5] above, wherein the stinging irritation-inducing component is one or more selected from parabens, phenoxyethanol, alkanediols having 6 or more carbon atoms, vitamin B6, and vitamin B12. [Effects of the Invention]

[0010] The present invention can provide a stinging irritation suppressant, a cosmetic, and a method for suppressing stinging irritation, which suppress the stinging irritation caused by a stinging-inducing component. DETAILED DESCRIPTION OF THE INVENTION

[0011] The stinging irritation inhibitor, cosmetic, and stinging irritation suppression method according to this embodiment will be described below, but the present invention is not limited to the following embodiment. The present invention is not limited to the individual configurations described below, and various modifications are possible within the scope of the claims. Embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, in this specification, unless otherwise specified, "A to B" representing a numerical range means "greater than or equal to A and less than or equal to B."

[0012] In this specification, the term "stinging stimulation" encompasses irritation sensations such as prickling, tingling, burning, hot flashes, and cold sensations that occur when applied to the skin, and further refers to sensations that are felt as sensory stimulation but do not cause serious skin symptoms such as redness, peeling, or rough skin.

[0013] <Stinging irritation suppressant> The stinging stimulus inhibitor according to this embodiment, which suppresses the stinging stimulus caused by the stinging stimulus-inducing component, contains nicotinamide as an active ingredient.

[0014] <Nicotinamide> The active ingredient in the stinging irritation inhibitor according to this embodiment is nicotinamide. Nicotinamide, also known as nicotinamide and niacinamide, is an amide of niacin (vitamin B3) and is a water-soluble vitamin with a molecular weight of 122.12 and CAS registration number 98-92-0. Nicotinamide is a component commonly used in cosmetics as a beauty ingredient for moisturizing, anti-inflammatory, whitening, etc., and is available as a commercially available cosmetic ingredient. Nicotinamide is known as a beauty ingredient for the skin, but there have been no reports to date of its effectiveness in preventing stinging irritation, which is a sensory irritation.

[0015] The nicotinamide in the stinging stimulus inhibitor according to this embodiment can suppress the stinging stimulus on the skin caused by the stinging stimulus-inducing component described below. This is presumably because the nicotinamide and the stinging stimulus-inducing component form a complex on the skin surface, reducing their permeability into the skin.

[0016] <Stinging stimulus-inducing ingredient> The stinging stimulus inhibitor according to this embodiment suppresses stinging stimulus from a stinging stimulus inducing component, i.e., a component that inflicts stinging stimulus on the skin. Here, inducing stinging stimulus means inducing a stinging sensation on the skin, rather than causing symptoms such as inflammation, suppuration, or rough skin. The stinging stimulus inducing component is not particularly limited as long as it induces stinging stimulus on the skin, but examples include paraben, phenoxyethanol, alkanediols having 5 or more carbon atoms, vitamin B5, and vitamin B12.

[0017] Parabens are esters of parahydroxybenzoic acid and are used as preservatives. Parabens can be industrially synthesized from petroleum and are commonly sold as raw materials for cosmetics. Specific examples of parabens include methylparaben, ethylparaben, propylparaben, and butylparaben. When parabens are included in cosmetics, they are generally contained in a range of 0.01% to 0.5% by mass.

[0018] Phenoxyethanol is a monoether of phenol and ethylene glycol, and is commonly used in cosmetics as a preservative. Phenoxyethanol can be industrially synthesized from petroleum and is commonly sold as a cosmetic ingredient. When phenoxyethanol is added to cosmetics, its content is generally in the range of 0.01% to 1.0% by mass.

[0019] 1,2-alkanediols with 5 or more carbon atoms are commonly used in skin cosmetics as moisturizing ingredients, but they are also known to have excellent bacteriostatic and antiseptic properties. 1,2-alkanediols with 5 or more carbon atoms become more hydrophobic, which increases their antiseptic properties, but it is also known that the stinging irritation to the skin increases accordingly. 1,2-alkanediols can be synthesized from crude materials derived from petroleum or plants, and commercially available products can be used as raw materials for cosmetics. Specific examples of alkanediols having 5 or more carbon atoms include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol. Furthermore, when 1,2-alkanediols having 5 or more carbon atoms are incorporated into cosmetics, their content is generally within the range of 0.1% to 5.0% by mass.

[0020] Vitamin B6, also known as pyridoxine hydrochloride, is a pyridine derivative used in cosmetics as a beauty ingredient to promote skin metabolism and control sebum production. Vitamin B6 can be industrially synthesized from petroleum and is commonly sold as a cosmetic ingredient. When vitamin B6 is included in cosmetics, it is generally contained in a range of 0.0001% to 0.5% by mass.

[0021] Vitamin B12, also known as cyanocobalamin, is a component with a porphyrin structure, and its aqueous solution is bright pink to red. In cosmetics, it is used as an anti-inflammatory component or a coloring component. Vitamin B12 can be synthesized industrially from petroleum or by fermentation using microorganisms, and is commonly sold as a cosmetic ingredient. When vitamin B12 is included in cosmetics, its content is generally in the range of 0.0001% to 0.05% by mass.

[0022] The stinging stimulus suppressant according to this embodiment contains nicotinamide as an active ingredient, and is therefore capable of suppressing the stinging stimulus caused by the stinging-inducing component.

[0023] <Cosmetics> The cosmetic according to this embodiment contains nicotinamide and a stinging stimulus-inducing component. The nicotinamide and the stinging stimulus-inducing component are as described above. In the cosmetic according to this embodiment, the blending amount of nicotinamide in the cosmetic is preferably 0.1% by mass or more. When the nicotinamide is 0.1% by mass or more, the stinging stimulus to the skin caused by the stinging stimulus-inducing component in the general blending amount contained in the cosmetic can be sufficiently suppressed.

[0024] <Other ingredients> In addition to the above-mentioned nicotinamide and stinging stimulation-inducing component, the cosmetic composition according to this embodiment may contain other components as appropriate, provided that the purpose of the present invention is not impaired, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, emollients, polymeric compounds, thickeners, polysaccharides, powders (colorants, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, vitamins, amino acids, and other components.

[0025] Furthermore, the cosmetic composition according to this embodiment may contain an appropriate physiologically active ingredient, provided that the objectives of the present invention are not impaired. A physiologically active substance is a substance that imparts some physiological activity to the skin when applied to the skin, and examples thereof include whitening agents, anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, cooling agents, warming agents, wound healing promoters, irritation soothing agents, analgesics, and cell activators.

[0026] The cosmetic composition according to this embodiment can be produced by a conventional method. Examples of the cosmetic composition according to this embodiment include lotions, emulsions, creams, beauty serums, gels, sheet masks, and the like. Examples of the cosmetic product include face wash, makeup, body lotion, body gel, body cream, facial soap, facial cleanser, body soap, cleansing agent, and makeup base. The dosage form can also be selected arbitrarily depending on the purpose. Examples include liquid, cream, gel, emulsion, sheet, stick, and aerosol forms. The cosmetic product according to this embodiment is not limited to general skin cosmetics, but also includes quasi-drugs, designated quasi-drugs, and topical medicines.

[0027] Furthermore, because stinging irritation is closely related to the amount and duration of time that a cosmetic is applied to the skin, a cosmetic that fully utilizes the stinging irritation suppression effect of the cosmetic according to this embodiment is a facial pack. Since a large amount of cosmetic remains and accumulates on the skin for a long period of time, facial packs are particularly prone to causing stinging irritation. The stinging irritation suppression effect of the cosmetic according to this embodiment is also fully applicable to the irritation caused by such cosmetics.

[0028] The cosmetic composition according to this embodiment contains nicotinamide, and thus can suppress the stinging irritation caused by the stinging-inducing component.

[0029] <Method for suppressing stinging stimuli> In the method for suppressing stinging according to this embodiment, stinging caused by a stinging-inducing component is suppressed by nicotinamide. Nicotinamide and the stinging-inducing component are as described above.

[0030] The method for suppressing stinging stimulation according to this embodiment contains nicotinamide, and thus the stinging stimulation caused by the stinging-inducing component can be suppressed by nicotinamide. [Example]

[0031] The present invention will now be described in detail with reference to examples, but is not limited thereto. Prior to the examples, the test and evaluation methods employed in each example will be described.

[0032] <Stinging stimulation suppression test> A sheet mask was prepared by impregnating 18 mL of each cosmetic composition from each Example and Comparative Example onto a rayon nonwoven fabric (basis weight: 50 g) cut into the shape of a face. Five expert panelists applied the sheet mask for 10 minutes and evaluated whether they felt any stinging sensation during application or within one hour after application, based on the following scale. The scores were calculated using the average of the five panelists and categorized as follows:

[0033] <Rating for the effect of suppressing stinging stimuli> 5 points: No stinging sensation felt at all. 4 points: A slight stinging sensation is felt, but it is not unpleasant. 3 points: There is a slight stinging sensation, but it is not unpleasant. 2 points: I feel a stinging sensation, but it's not uncomfortable. 1 point: You feel a stinging sensation and it is uncomfortable. <Evaluation criteria for stinging stimulus suppression effect> ◎: The average score of the 5 participants was 4.0 points or higher. ○: The average score of the 5 people was 3.0 points or more and less than 4.0 points. △: The average score of the 5 people was 2.0 or more and less than 3.0 points. ×: The average score of 5 people was less than 2.0 points.

[0034] <Examples 1 to 28 and Comparative Examples 1 to 12> The cosmetics having the formulations of Examples 1 to 28 and Comparative Examples 1 to 12 shown in Tables 1 to 5 were prepared in a conventional manner. The results are shown in Tables 1 to 5.

[0035] [Table 1]

[0036] [Table 2]

[0037] [Table 3]

[0038] [Table 4]

[0039] [Table 5]

[0040] As can be seen from Tables 1 to 5, Examples 1 to 28, which contain nicotinamide, have a high effect of suppressing the stinging stimulus caused by the stinging stimulus-inducing component, whereas Comparative Examples 1 to 12, which do not contain nicotinamide, have a low effect of suppressing the stinging stimulus. This indicates that nicotinamide acts as an active ingredient to suppress the stinging stimulus.

Claims

1. A stinging stimulus suppressant containing nicotinamide as an active ingredient, which suppresses stinging stimulus caused by a stinging stimulus inducing component.

2. The stinging stimulus suppressant according to claim 1, wherein the stinging stimulus inducing component is one or more selected from parabens, phenoxyethanol, alkanediols having 6 or more carbon atoms, vitamin B6, and vitamin B12.

3. A cosmetic that suppresses stinging irritation, comprising nicotinamide and a component that induces stinging irritation.

4. 4. The cosmetic according to claim 3, wherein the stinging stimulation inducing component is one or more selected from the group consisting of parabens, phenoxyethanol, alkanediols having 6 or more carbon atoms, vitamin B6, and vitamin B12.

5. A method for suppressing stinging stimulation, which uses nicotinamide to suppress stinging stimulation caused by a stinging stimulation-inducing component.

6. 6. The method for suppressing stinging irritation according to claim 5, wherein the stinging irritation-inducing component is one or more selected from parabens, phenoxyethanol, alkanediols having six or more carbon atoms, vitamin B6, and vitamin B12.

Images