Fungicide combinations

Abstract

The present invention provides a fungicide combination comprising ipconazole and thiabendazole for controlling infestation by saprophytic phytopathogenic fungi in crops.The present invention provides a fungicide combination comprising ipconazole and thiabendazole for controlling infestation by saprophytic phytopathogenic fungi in seed treatment crops.The present invention further relates to a method for controlling phytopathogenic fungi.

Description

[Technical field]

[0001] The present disclosure relates to a fungicide combination effective against plant pathogenic fungi. More specifically, the present disclosure relates to a fungicide combination comprising ipconazole and thiabendazole for effectively controlling plant pathogenic fungi, including saprophytic fungi. The present disclosure relates to a method for controlling plant pathogenic fungi. The present disclosure also relates to a method for controlling Rhizoctonia fungi and Sclerotinia sclerotiorum. [Background technology]

[0002] Achieving the production of high-quality, nutritious crops with efficient yields is a priority for farmers amid the infestation of crops by pests. It is therefore incumbent on farmers to provide optimal growing conditions for plants under existing field conditions and to protect them from damage caused by pests, including weeds, insects and fungal pathogenic microorganisms. Plant diseases result in an annual estimated loss of 10-15% of the world's major crops, with direct economic losses of which 70-80% of these diseases are caused by pathogenic fungi. Plant pathogenic fungi have a negative impact on crop growth and yield. In recent years, fungal diseases of crops have become increasingly serious, as they severely affect crop yield and quality, and have become a bottleneck in the development of sustainable agriculture. The use of synthetic pesticides to control and inhibit fungal plant pathogens has become an integral part of modern agriculture and is one of the main reasons for the dramatic increase in crop productivity.

[0003] The main factor that determines the efficacy of a pesticide is its unique mode of action. Fungicides are usually called single-site inhibitors because they attack a specific metabolic protein or metabolic process in plant pathogens. Almost all single-site or systemic fungicides are high-risk fungicides because a single mutation in the gene that codes for the target molecule is likely to prevent the binding of the active fungicidal component. The sustained use of single-site inhibitors can result in the development of fungicide resistance or insusceptibility. When only one or a few genes are involved, fungicide treatments result in the selection of fungal subpopulations of sensitive or extremely highly resistant strains.

[0004] The fungal genus Rhizoctonia belongs to the family Ceratobasidiaceae, order Cantharellales, class Agaricomycetes, division Basidiomycota, and has a very large number of susceptible host plants. Rhizoctonia species are necrotrophic pathogens, which precede fungal growth and kill the host cell by secretion of enzymes and toxins before colonizing it. Rhizoctonia is a soil-borne fungus known to cause root rot, sclerotinia rot, dieback, and in some cases leaf dieback, among other symptoms / diseases. Rhizoctonia is present in most soils, has a high survival rate, and causes disease in almost all cultivated crops.

[0005] Rhizoctonia species are strong saprophytes. They survive for long periods in the absence of living host plants by feeding on decaying organic matter. Losses due to Rhizoctonia include reduced numbers of newly planted plants in the field, early death of diseased plants, and production of small seeds. Rhizoctonia solani can cause seed rot, root rot, and lesions on hypocotyls. If germinating seedlings are infected before emergence, damping off occurs. Reddish-brown, sunken lesions form on the hypocotyls of young seedlings. The resulting hard, dry canker can surround the seedling and cause it to collapse.

[0006] Yield losses due to Rhizoctonia species infestation in the United States, Canada and Australia have been reported to be up to 50%. Azalea, hydrangea, osteospermum, pittosporum, poinsettia, rosemary and vince crops are listed as crops susceptible to cutting rot. Celosia, gomphrena, impatiens, snapdragon, stock and vinca crops are listed as crops susceptible to damping off. Aster, dianthus, impatiens, poinsettia and pothos crops are among the crops susceptible to sclerotinia disease. Agrionema, azalea, begonia, campanula, fern, holly, impatiens, juniper, philodendron, poansettia and spathiphyllum crops are among the crops susceptible to root rot. Azalea, holly, juniper and pittosporum crops are among the crops susceptible to leaf rot.

[0007] Demethylation inhibitors (a type of sterol synthesis inhibitor) are known to control Rhizoctonia fungi. They inhibit the biosynthesis of ergosterol, which is a major component of the plasma membrane of certain fungi and is necessary for fungal growth. Fungicide inhibitors of β-tubulin assembly are known to control Rhizoctonia fungi. They are fungicidal compounds that exert their biological activity by preventing cell division through the inhibition of tubulin polymerization, the main component of microtubules. Rhizoctonia fungi have a wide range of host plants, have excellent survival rates in soil, have a very large number of countries affected by them, and cause large losses of crop and seed yields worldwide, making them a very difficult, important and urgent problem to address.

[0008] Sclerotinia sclerotiorum is one of the most destructive generalist plant pathogens. Diseases caused by this fungal pathogen include cottony rot, watery soft rot, sclerotinia sclerotinia, leaf drop, crown rot, flower blight, and white mold. The fungus infects over 400 species of plants worldwide, including important crops and numerous weeds.

[0009] Despite the continuous use of these single-site inhibitor fungicides or systemic fungicides to control pathogenic saprophytic fungi in crops, damage caused by fungal infestation has an impact in terms of economic loss and reduced crop quality.Therefore, the present inventors aimed to provide a novel synergistic combination for effectively controlling fungal infestation in crops.

[0010] the purpose: It is an object of the present disclosure to provide fungicide combinations for effectively controlling infestations by plant pathogenic fungi.

[0011] Another object of the present disclosure is to provide a synergistic fungicidal combination for effectively controlling infestations by saprophytic phytopathogenic fungi.

[0012] Another object of the present disclosure is to provide a synergistic fungicide combination for effectively controlling infestation by saprophytic plant pathogenic fungi, said combination being suitable for seed treatment.

[0013] Another object of the present disclosure is to provide a fungicide composition for controlling infestation by phytopathogenic fungi.

[0014] Another object of the present disclosure is to provide a seed treatment composition for controlling infestation by phytopathogenic fungi.

[0015] It is an object of the present disclosure to provide a method of controlling fungi using a synergistic combination, the combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0016] Another object of the present disclosure is to provide a method for controlling saprophytic fungi using a synergistic combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0017] Another object of the present disclosure is to provide a method of controlling Rhizoctonia fungus using a synergistic combination, the combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0018] It is an object of the present disclosure to provide the use of a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide for controlling fungal infestation in crops.

[0019] It is an object of the present disclosure to provide the use of a fungicide composition comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide for controlling fungal infestation in crop plants. Summary of the Invention

[0020] The present disclosure provides a fungicidal combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0021] In one aspect, the present disclosure provides: (i) at least one demethylation inhibitor fungicide selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole, and (ii) at least one β-tubulin assembly fungicide selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; The present invention provides a synergistic fungicidal combination comprising:

[0022] In one aspect, the present disclosure provides a synergistic fungicidal combination comprising ipconazole and thiabendazole.

[0023] In one aspect, the disclosure provides a synergistic fungicide combination comprising ipconazole and thiabendazole, the combination being suitable for seed treatment.

[0024] In another aspect, the present disclosure provides a synergistic fungicidal composition for effectively controlling fungal infestation in crops, the composition comprising: (i) at least one demethylation inhibitor fungicide selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole; (ii) at least one β-tubulin assembly fungicide selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; and (iii) Agriculturally acceptable excipients The present invention provides a composition comprising:

[0025] In one aspect, the present disclosure provides a synergistic fungicidal composition comprising ipconazole, thiabendazole, and an agriculturally acceptable excipient for effectively controlling fungal infestation in crops.

[0026] The present disclosure provides seed treatment compositions comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0027] In one aspect, the present disclosure provides a seed treatment composition comprising ipconazole, thiabendazole, and an agriculturally acceptable excipient for effectively controlling fungal infestation in crops.

[0028] In one aspect, the disclosure provides a method for controlling plant pathogenic fungi by applying a synergistic combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide to a locus of a plant, plant part or propagation material.

[0029] In another aspect, the disclosure provides a method of controlling phytopathogenic fungi by applying a synergistic combination at a locus of a plant, plant part, or propagation material, the combination comprising: (i) at least one demethylation inhibitor fungicide selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole, and (ii) at least one β-tubulin assembly fungicide selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; The present invention provides a method comprising:

[0030] In one aspect, the disclosure provides a method of controlling plant pathogenic fungi by applying a synergistic combination comprising ipconazole and thiabendazole to a plant, plant part, or locus of propagation material.

[0031] In another aspect, the disclosure provides a method of controlling Rhizoctonia infestation in crops by applying a combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide.

[0032] In another aspect, the disclosure provides a method of controlling Rhizoctonia fungus using a synergistic combination, the combination comprising: (i) at least one demethylation inhibitor fungicide selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole, and (ii) at least one β-tubulin assembly fungicide selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; The present invention provides a method comprising:

[0033] In another aspect, the disclosure provides a method of controlling Rhizoctonia fungal infestation in crops by applying a combination comprising ipconazole and thiabendazole.

[0034] In another aspect, the present disclosure provides a method of controlling Sclerotinia sclerotiorum infestation in crops by applying a combination comprising ipconazole and thiabendazole.

[0035] In yet another aspect, the present disclosure provides the use of a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide for controlling fungal infestation in a crop.

[0036] In yet another aspect, the present disclosure provides the use of a fungicide combination comprising ipconazole and thiabendazole to control fungal infestation in crops.

[0037] In yet another aspect, the present disclosure provides the use of a fungicide composition comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide for controlling fungal infestation in a crop.

[0038] In yet another aspect, the present disclosure provides the use of a fungicide composition comprising ipconazole and thiabendazole for controlling fungal infestation in crops. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0039] Detailed Description Before describing the present disclosure in detail, it should be understood that the present disclosure is not limited to the particularly exemplified system or process parameters, which may of course vary. It should also be understood that the terms used herein are for the purpose of describing particular embodiments of the present disclosure only, and are not intended to limit the scope of the present disclosure in any way. The use of examples anywhere in the present specification, including examples of any term discussed herein, is illustrative only and in no way limits the scope and meaning of the present disclosure or any exemplified term.

[0040] It should be noted that as used herein, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. The terms "preferred" and "preferably" refer to embodiments of the present disclosure that may provide certain benefits, under particular circumstances.

[0041] As used herein, the terms "comprising," "including," "having," "containing," "involving," and the like, should be understood to be open-ended, i.e., to mean including but not limited to.

[0042] The term "plant propagation material" refers to parts of plants, such as seeds, that can be used to propagate plants and vegetative plant material. For example, plant parts can include seeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes. Included herein are sprouted plants or seedlings that can be transplanted after germination or emergence from the soil.

[0043] The term "seed" encompasses all types of seeds and plant propagation materials, including, but not limited to, true seeds, seed parts, suckers, corms, bulbs, fruits, tubers, grains, cuttings, stalks, etc. In a preferred embodiment, the seed is a true seed.

[0044] The term "seed" may also include transgenic seeds, i.e., seeds of transgenic plants. As used herein, "transgenic plant" refers to a plant or its progeny derived from a transformed plant cell or protoplast, in which the plant DNA contains an introduced exogenous DNA molecule that is not naturally present in a native non-transgenic plant of the same lineage.

[0045] "Fungicidal" refers to the ability of a substance to reduce or inhibit the growth of fungi.

[0046] "Control" or "controlling" a fungus means inhibiting and / or suppressing the ability of the fungus to grow and / or reproduce, or limiting fungal damage or loss in crop plants, or means controlling and preventing disease. Control effects include any deviation from natural occurrence, e.g., killing, delaying, reducing disease.

[0047] As used herein, the term "locus" is intended to refer to the vicinity of a desired crop plant where it is desired to control the spread of a phytopathogenic fungus. The locus includes the vicinity of a desired crop plant where a phytopathogenic fungal infection has appeared, is most likely to appear, or has not yet appeared.

[0048] According to the present disclosure, "increased yield" of an agricultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of a plant produced under the same conditions without application of a composition described herein.

[0049] According to the present disclosure, crop yield is preferably increased by at least 0.5%, preferably at least 2%, more preferably at least 5% when applying the combinations and compositions described herein.Therefore, a fungicide combination useful for combating Rhizoctonia fungi is provided.The compositions also increase plant vigor / yield.

[0050] Surprisingly, the problems described above are solved by the combination of active compounds and / or methods as defined herein. The inventors have unexpectedly found that application of a fungicide combination comprising a demethylation inhibitor fungicide and a β-tubulin assembly inhibitor fungicide significantly enhances crop plant health, crop yield and reduction of fungal disease caused by phytopathogenic fungi. More specifically, the inventors have unexpectedly found that application of a fungicide combination of the present invention comprising ipconazole and thiabendazole in a specific ratio significantly enhances crop plant health, crop yield and reduction of fungal disease caused by saprophytic plant fungi such as Rhizoctonia spp. and Sclerotinia sclerotiorum. The present inventors have treated the seeds of crops susceptible to fungal infestation by phytopathogenic fungi, primarily saprophytic fungi, with a fungicide combination comprising ipconazole and thiabendazole to achieve highly effective and synergistic control of pathogenic fungi. Improved crop health and reduced fungal disease were achieved by applying the inventive combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly fungicide.

[0051] The present disclosure provides a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide for effectively controlling plant pathogenic fungi.

[0052] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide The present invention provides a fungicidal combination comprising:

[0053] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, To provide a combination of fungicides which is suitable for seed treatment and which effectively controls saprophytic phytopathogenic fungi.

[0054] In one embodiment, the present disclosure provides a fungicide combination for controlling saprophytic phytopathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, The present invention provides a fungicide combination, wherein the plant pathogenic fungi are of the genus Rhizoctonia, Rhizoctonia solani and Sclerotinia sclerotiorum.

[0055] In one embodiment, a synergistic fungicide combination for controlling Rhizoctonia species, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide The present invention provides a fungicidal combination comprising:

[0056] In one embodiment, the present disclosure provides a synergistic fungicidal combination for controlling the Sclerotinia sclerotiorum fungus, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide The present invention provides a fungicidal combination comprising:

[0057] In another embodiment, the demethylation inhibitor fungicide is selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole.

[0058] In another embodiment, the β-tubulin assembly inhibitor fungicide is selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl.

[0059] In one embodiment there is provided a synergistic fungicide combination for controlling fungal infestations in crops, comprising: (i) at least one demethylation inhibitor fungicide selected from azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole, and (ii) at least one β-tubulin assembly inhibitor fungicide selected from benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; A fungicidal combination is provided, comprising:

[0060] In an embodiment, the demethylation inhibitor fungicide is tebuconazole.

[0061] In an embodiment, the demethylation inhibitor fungicide is prothioconazole.

[0062] In an embodiment, the demethylation inhibitor fungicide is cyproconazole.

[0063] In an embodiment, the demethylation inhibitor fungicide is mefentrifluconazole.

[0064] In a preferred embodiment, the demethylation inhibitor fungicide is ipconazole.

[0065] In an embodiment, the β-tubulin assembly inhibitor fungicide is thiophanate.

[0066] In an embodiment, the β-tubulin assembly inhibitor fungicide is carbendazim.

[0067] In a preferred embodiment, the β-tubulin assembly inhibitor fungicide is thiabendazole.

[0068] In all fungicide combinations embodying the principles of the present disclosure, the demethylation inhibitor fungicides include their derivatives such as salts, esters, ethers, solvates, hydrates and polymorphs.

[0069] In all fungicide combinations embodying the principles of the present disclosure, the β-tubulin assembly inhibitor fungicides include derivatives thereof such as salts, esters, ethers, solvates, hydrates and polymorphs.

[0070] Salts include derivatives of the disclosed compounds, including salts which retain the biological effectiveness and properties of the active ingredients of the demethylation inhibitor fungicide and β-tubulin assembly inhibitor fungicide, which are not biologically or otherwise undesirable, and in which the parent compound is modified by making inorganic and organic non-toxic acid or base addition salts thereof. The salts can be synthesized from the parent compound by conventional chemical methods.

[0071] For brevity, demethylation inhibitor fungicides may be referred to herein by their corresponding short reference numbers, as referenced in the table below.

[0072] [Table 1]

[0073] For brevity, β-tubulin assembly inhibitor fungicides may be referred to herein by their corresponding short reference numbers, as mentioned in the table below.

[0074] [Table 2]

[0075] The following table lists some examples of fungicide combinations according to the present disclosure.

[0076] [Table 3]

[0077] In any of the embodiments, the genus Rhizoctonia should be read to include the species Rhizoctonia solani.

[0078] As used throughout this specification, Rhizoctonia solani should be understood to include Thanatephorus cucumeris, which is a synonym for the same fungus in different states / phases, and any other names assigned to it now or in the future.

[0079] As used throughout this specification, Rhizoctonia solani should be understood to include all states / phases.

[0080] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling fungal infestations in crops comprising ipconazole and thiabendazole.

[0081] In a preferred embodiment, the present disclosure provides a synergistic fungicide combination for controlling fungal infestations in crops comprising ipconazole and thiabendazole.

[0082] In another preferred embodiment, the present disclosure provides a saprophytic fungicide combination for controlling fungal infestations in crops comprising ipconazole and thiabendazole.

[0083] In another preferred embodiment, the present disclosure provides a fungicide combination for controlling saprophytic fungal infestation in crops comprising ipconazole and thiabendazole, wherein the phytopathogenic fungi are Rhizoctonia solani and Sclerotinia Sclerotinia sclerotiorum.

[0084] In another preferred embodiment there is provided a synergistic fungicide combination for controlling Rhizoctonia fungi comprising ipconazole and thiabendazole.

[0085] In another preferred embodiment, the present disclosure provides a synergistic fungicide combination for controlling Rhizoctonia solani, the combination comprising ipconazole and thiabendazole.

[0086] In another preferred embodiment there is provided a synergistic fungicidal combination for controlling Sclerotinia sclerotiorum comprising ipconazole and thiabendazole.

[0087] In one embodiment, the present disclosure provides a fungicide combination for controlling phytopathogenic fungi in crops, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, Combinations of fungicides are provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 0.5:100 to 100:0.5, 1:50 to 50:1, 1:25 to 25:1.

[0088] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 0.5:10 to 10:0.5.

[0089] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 1:10 to 10:1.

[0090] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 1:8 to 8:1.

[0091] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 1:5 to 5:1.

[0092] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 1:2 to 2:1.

[0093] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide Including, A fungicide combination is provided in which the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is 1:1.

[0094] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio ranging from 0.5:10 to 10:0.5.

[0095] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio ranging from 1:10 to 10:1.

[0096] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio ranging from 1:8 to 8:1.

[0097] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio ranging from 1:5 to 5:1.

[0098] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio of 1:9.

[0099] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio of 1:8.

[0100] In a preferred embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio of 1:6.

[0101] In one embodiment, the present disclosure provides a fungicide combination for controlling plant pathogenic fungi comprising ipconazole and thiabendazole in a ratio ranging from 1:2 to 2:1.

[0102] In an embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier Including, the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 0.5:100 to 100:0.5, 1:50 to 50:1, 1:25 to 25:1; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0103] In one embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier Including, the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 0.5:10 to 10:0.5; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0104] In a preferred embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier Including, the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide ranges from 1:10 to 10:1; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0105] In a preferred embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier Including, the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:8 to 8:1; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0106] In another embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:2 to 2:1; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0107] In one embodiment, the present disclosure provides a fungicide combination for seed treatment comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) Inert Carrier Including, the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is 1:6; A fungicidal combination is provided, which combination controls saprophytic, plant pathogenic fungi.

[0108] In a preferred embodiment, the disclosure provides a fungicide combination for seed treatment comprising ipconazole, thiabendazole and an inert material, wherein the ipconazole to thiabendazole ratio is in the range of 0.5:10 to 10:0.5, and the combination controls saprophytic phytopathogenic fungi.

[0109] In a preferred embodiment, the disclosure provides a fungicide combination for seed treatment comprising ipconazole, thiabendazole and an inert material, wherein the ipconazole and thiabendazole are in a ratio ranging from 1:5 to 5:1, and the combination controls saprophytic phytopathogenic fungi.

[0110] In a preferred embodiment, the disclosure provides a fungicide combination for seed treatment comprising ipconazole, thiabendazole and an inert material, wherein the ipconazole and thiabendazole are in a ratio ranging from 1:2 to 2:1, and the combination controls saprophytic phytopathogenic fungi.

[0111] In a preferred embodiment, the present disclosure provides a fungicide combination for seed treatment comprising ipconazole, thiabendazole and an inert material, wherein the ipconazole and thiabendazole are in a 1:1 ratio, and the combination controls saprophytic phytopathogenic fungi.

[0112] In an embodiment the combination of the present disclosure includes at least a third additional fungicide or herbicide or insecticide.

[0113] In one embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) a demethylation inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) a β-tubulin assembly inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds The present invention provides a fungicidal combination comprising:

[0114] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) a demethylation inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) a β-tubulin assembly inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 75 g / 100 kg of seeds The present invention provides a fungicidal combination comprising:

[0115] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) a demethylation inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) β-tubulin assembly inhibitor fungicides applied at rates ranging from 1 g / 100 kg of seed to 70 g / 100 kg of seed. The present invention provides a fungicidal combination comprising:

[0116] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) a demethylation inhibitor fungicide in an amount ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) a β-tubulin assembly inhibitor fungicide applied at rates ranging from 5 g / 100 kg of seed to 65 g / 100 kg of seed The present invention provides a fungicidal combination comprising:

[0117] In an embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) ipconazole applied in an amount ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) Thiabendazole applied at rates ranging from 1 g / 100 kg of seed to 80 g / 100 kg of seed. The present invention provides a combination of fungicides comprising:

[0118] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) ipconazole applied in an amount ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole applied at rates ranging from 1 g / 100 kg of seed to 75 g / 100 kg of seed. The present invention provides a combination of fungicides comprising:

[0119] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) ipconazole applied in amounts ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole applied at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds The present invention provides a combination of fungicides comprising:

[0120] In another embodiment, the present invention provides a synergistic fungicidal combination comprising: (i) ipconazole applied in amounts ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole applied at rates ranging from 5 g / 100 kg of seed to 65 g / 100 kg of seed. The present invention provides a combination of fungicides comprising:

[0121] In one embodiment, the combination of the present disclosure includes at least an additional fungicide.

[0122] In one embodiment, the systemic fungicide can be a single fungicide or a combination of one or more systemic fungicides.

[0123] In one embodiment, the systemic fungicide is a combination of at least two fungicides.

[0124] In one embodiment, the systemic fungicide in the combination may be selected from nucleic acid synthesis inhibitors, cytoskeletal and motor protein inhibitors, amino acid and protein synthesis inhibitors, respiratory process inhibitors, signal transduction inhibitors, lipid synthesis and membrane integrity disruptors, sterol biosynthesis inhibitors, melanin synthesis inhibitors, cell wall biosynthesis inhibitors, cell wall melanin synthesis inhibitors, host plant defense inducers, fungicides with an unknown mode of action, unclassified fungicides, or biologics with multiple modes of action.

[0125] Thus, in one embodiment, the nucleic acid synthesis inhibitor fungicide may be selected from acylalanines such as benalaxyl, benalaxyl-M (chiralaxyl), furalaxyl, metalaxyl, metalaxyl-M (mefenoxam), oxazolidinones such as oxadixyl, butyrolactones such as ofurase, hydroxy-(2-amino-)pyrimidines such as bupirimate, isoxazoles such as dimethylimol, ethirimol, hymexazole, isothiazolones such as octhilinone, carboxylic acids such as oxolinic acid.

[0126] In one embodiment, the cytoskeletal and motor protein inhibitor can be a benzimidazole, e.g., benomyl, carbendazim, fuberidazole, thiabendazole, a thiophanate such as thiophanate, a thiophanate-methyl, an N-phenylcarbamate such as diethofencarb, a toluamide such as zoxamide, a thiazolecarboxamide such as ethaboxam, a phenylurea such as pencycuron, a benzamide such as fluopicolide, a cyanoacrylate such as phenamacryl.

[0127] In one embodiment, the respiratory process inhibitor fungicide is selected from the group consisting of pyrimidinamines (e.g., diflumetrim), pyrazole-5-carboxamides (e.g., tolfenpyrad), strobilurins (e.g., azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb, and mixtures thereof), oxazolidine-diones (e.g., famoxadone), imidazolinones (e.g., fenisoxystrobin, phen ... N-aminonamide), benzyl carbamates (e.g. pyribencarb), N-methoxy-(phenyl-ethyl)-pyrazole-carboxamides (e.g. pyrimidine amines, e.g. diflumetrim), cyano-imidazoles (e.g. cyazofamidosulfamoyl-triazoles, e.g. amisulbrom), dinitrophenyl crotonates (e.g. binapacryl), meptyl dinocap, dinocap, 2,6-dinitroanilines (e.g. fluazinam), pyrhydrazones (e.g. ferimzone), triphenyltin compounds (e.g. fentin acetate, fentin chloride, fentin hydroxide), thiophene-carboxamides (e.g. silthiofam), triazolo-pyrimidylamines (e.g. amethotrazine).

[0128] In one embodiment, the amino acid and protein synthesis inhibitor fungicide may be selected from anilino-pyrimidines such as cyprodinil, mepanipyrim, pyrimethanil, antibiotic fungicides such as blasticidin-S, kasugamycin, streptomycin, oxytetracycline, and the like.

[0129] In one embodiment, the signal transduction inhibitor fungicide may be selected from aryloxyquinolines (e.g., quinoxyfen), quinazolinones (e.g., proquinazide), phenylpyrroles (e.g., fenpiclonil, fludioxonil), dicarboximides (e.g., chlozolinate, dimethaclon, iprodione, procymidone, and vinclozolin).

[0130] In one embodiment, the third fungicide may be selected from lipid synthesis and membrane integrity enhancers, such as phosphothiolates (e.g., edifenphos, iprobenfos, pyrazophos), dithiolanes (e.g., isoprothiolane), aromatic hydrocarbons (e.g., biphenyl, chloroneb, dicloran, quintozene (PCNB), tecnazene (TCNB), tolclofos-methyl, etc.), 1,2,4 thiadiazoles (e.g., etridiazole), carbamates (e.g., iodocarb, propamocarb, prothiocarb, etc.).

[0131] Thus, in one embodiment, the sterol biosynthesis inhibitor is a triazole (e.g., azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxoconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibeconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, prothioconazole), piperazine (e.g., triforine), pyridine (e.g., pyrif The amines may be selected from the group consisting of phenox, pyrisoxazole, pyrimidines (e.g. fenarimol), nuarimol imidazoles (e.g. imazalil, oxoconazole, pefurazoate, prochloraz, triflumizole), morpholines (e.g. aldimorph, dodemorph, fenpropimorph, tridemorph, etc., piperidines (e.g. fenpropidin, piperalin), spiroketal amines (e.g. spiroxamine), hydroxyanilides (e.g. fenhexamid), amino-pyrazolinones (e.g. fenpyrazamine), thiocarbamates (e.g. pyributicarb), allylamines (e.g. naftifine, terbinafine) and mixtures thereof.

[0132] In one embodiment, the cell wall biosynthesis inhibitor fungicide may be selected from peptidyl pyrimidine nucleoside fungicides such as polyoxins, cinnamic acid amides such as dimethomorph, flumorph, pyrimorph, valinamide carbamates such as benthiavalicarb, iprovalicarb, valifenalate, mandelic acid amides such as mandipropamide, and mixtures thereof.

[0133] In one embodiment, the melanin synthesis inhibitor fungicide may be selected from isobenzo-furanones (e.g., fthalide), pyrroloquinolinones (e.g., pyroquilon), triazolobenzo-thiazoles (e.g., tricyclazole), cyclopropane-carboxamides (e.g., carpropamid), carboxamides (e.g., diclocymet), propionamides (e.g., fenoxanil), trifluoroethyl-carbamates (e.g., tolprocarb), and mixtures thereof.

[0134] In one embodiment, the host plant defense inducer fungicide may be selected from benzo-thiadiazoles such as acibenzolar-S-methyl, benzisothiazoles such as probenazole, thiadiazole-carboxamides such as thiadinil, isotianil, polysaccharides such as laminarin, and mixtures thereof.

[0135] In another embodiment, the ergosterol biosynthesis inhibitor may be selected from prothioconazole, tebuconazole, hexaconazole, cycloconazole, or epoxiconazole.

[0136] In one embodiment, the systemic fungicide may be a quinone external (QoI) inhibitor fungicide selected from azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb, and mixtures thereof.

[0137] In one embodiment, the quinone external inhibitor (QoI) fungicide may be selected from azoxystrobin, picoxystrobin, kresoxim-methyl, pyraclostrobin and trifloxystrobin.

[0138] In one embodiment, the third systemic fungicide is selected from a quinone external inhibitor, a quinone internal inhibitor, a demethylation inhibitor and / or a succinate dehydrogenase inhibitor; (i) the quinone external inhibitor is selected from fenamidone, famoxadone, and a strobilurin fungicide selected from the group consisting of azoxystrobin, mandestrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, pyraoxystrobin, dimoxystrobin, enestrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyrametostrobin, triclopyricarb, phenaminestrobin, pyraclostrobin, and trifloxystrobin; (ii) Demethylation inhibitors include triflumizole, triforine, pyridinitrile, pyrifenox, fenarimol, nuarimol, triarimol, climbazole, clotrimazole, imazalil, oxoconazole, prochloraz, prochlorazmanganese, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, and flutrimazole. , flukinokinazole, flusilazole, flutriafol, fluconazole, fluconazole, fluconazole-cis, hexaconazole, imibeconazole, ipconazole, metconazole, myclobutanil, pencoconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, perfurazoate and uniconazole-P; (iii) an internal quinone inhibitor selected from cyazofamid and amisulbrom, and (iv) A succinate dehydrogenase inhibitor selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane and boscalid.

[0139] In one embodiment, the multi-site fungicide is selected from the group consisting of copper (different salts), sulfur, ferbam, mancozeb, maneb, metiram, propineb, thiram, zinc thiazole, zineb, ziram, captan, captafol, folpet, chlorothalonil, dichlofluanid, tolylfluanid, guazatine, iminoctadine, anilazine, dithianone, quinomethionate / quinomethionate, fluoroimide and methasulfocarb.

[0140] In one embodiment, the dithiocarbamate fungicide is selected from the group consisting of amovam, azomate, azithiram, carbamorph, kufuraneb, cuprobam, disulfiram, ferbam, metham, nabam, tecoram, thiram, urvacid, ziram, dazomet, ethem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb, and zineb.

[0141] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides Combinations are provided that include:

[0142] In one embodiment, a synergistic fungicide combination for controlling Rhizoctonia spp. comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides Combinations are provided that include:

[0143] In one embodiment, a synergistic fungicidal combination for controlling Sclerotinia sclerotiorum species, comprising: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides Combinations are provided that include:

[0144] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Metalaxyl or Metalaxyl-M Combinations are provided that include:

[0145] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Carboxin Combinations are provided that include:

[0146] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) metalaxyl or metalaxyl-M, and (iv) Carboxin Combinations are provided that include:

[0147] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Chilam Combinations are provided that include:

[0148] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Fluazinam Combinations are provided that include:

[0149] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Cyazofamid Combinations are provided that include:

[0150] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Fluopyram Combinations are provided that include:

[0151] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) metalaxyl or metalaxyl-M, and (iv) Carboxin Combinations are provided that include:

[0152] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more pesticides Combinations are provided that include:

[0153] In one embodiment, a synergistic fungicide combination for controlling Rhizoctonia spp. comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more pesticides Combinations are provided that include:

[0154] In one embodiment, a synergistic fungicidal combination for controlling Sclerotinia sclerotiorum comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more pesticides Combinations are provided that include:

[0155] In one embodiment, the insecticide is derived from one or more of the following: acetylcholinesterase (AChE) inhibitors, ryanodine receptor modulators, GABA-gated chloride channel blockers, sodium channel modulators, nicotinic acetylcholine receptor (nAChR) competitive modulators, glutamatergic chloride channel (GluCl) allosteric modulators, chordate organ TRPV channel modulators, inhibitors of mitochondrial ATP synthase, mite growth inhibitors affecting CHS1, molting disruptors, microbial disruptors of insect midgut membranes, inhibitors of acetyl-CoA carboxylase, mitochondrial complex electron transport inhibitors, ecdysone receptor agonists, inhibitors of chitin biosynthesis.

[0156] In one embodiment, the insecticide is derived from one or more of the ryanodine receptor modulators including chlorantraniliprole, cyantraniliprole, cyclaniliprole, flubendiamide, and tetraniliprole.

[0157] In one embodiment, the insecticide is derived from one or more of the acetylcholinesterase (AChE) inhibitors, including carbamates and organophosphates.

[0158] In one embodiment, the insecticide is derived from one or more of the nicotinic acetylcholine receptor (nAChR) competitive modulators, including neonicotinoids, including acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam.

[0159] In one embodiment, the insecticide is a sodium channel modulator, including pyrethroids, and pyrethrins, including acrinathrin, allethrin, d-cis-trans-allethrin, d-trans-allethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer, bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, [( 1R)-trans-isomer], deltamethrin, empenthrin (EZ)-(1R)-isomer], esvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, imiprothrin, kadethrin, permethrin, fenothrin [(1R)-trans-isomer], prallethrin, pyrethrins (pyrethrins), resmethrin, silafluofen, tefluthrin, tetramethrin, tetramethrin [(1R)-isomer], tralomethrin, and transfluthrin.

[0160] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Flupirimine Combinations are provided that include:

[0161] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) flonicamid Combinations are provided that include:

[0162] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Chlorantraniliprole Combinations are provided that include:

[0163] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Cyantraniliprole Combinations are provided that include:

[0164] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Clothianidin Combinations are provided that include:

[0165] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Thiamethoxam Combinations are provided that include:

[0166] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Imidacloprid Combinations are provided that include:

[0167] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) Fipronil Combinations are provided that include:

[0168] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides and insecticides Combinations are provided that include:

[0169] In one embodiment, a synergistic fungicide combination for controlling Rhizoctonia spp. comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides and insecticides Combinations are provided that include:

[0170] In one embodiment, a synergistic fungicidal combination for controlling Sclerotinia sclerotiorum comprises: (i) ipconazole, (ii) thiabendazole, and (iii) one or more fungicides and insecticides Combinations are provided that include:

[0171] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) metalaxyl or metalaxyl-M, and (iv) one or more of flupirimine, flonicamid, chlorantraniliprole, cyantraniliprole, clothianidin, thiamethoxam, imidacloprid, or fipronil Combinations are provided that include:

[0172] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) carboxin, and (iv) one or more of flupirimine, flonicamid, chlorantraniliprole, cyantraniliprole, clothianidin, thiamethoxam, imidacloprid, or fipronil Combinations are provided that include:

[0173] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) Thiram, and (iv) one or more of flupirimine, flonicamid, chlorantraniliprole, cyantraniliprole, clothianidin, thiamethoxam, imidacloprid, or fipronil Combinations are provided that include:

[0174] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) fluazinam, and (iv) one or more of flupirimine, flonicamid, chlorantraniliprole, cyantraniliprole, clothianidin, thiamethoxam, imidacloprid, or fipronil Combinations are provided that include:

[0175] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) Cyazofamid, and (iv) one or more of flupirimine or flonicamid or chlorantraniliprole or cyantraniliprole or clothianidin or thiamethoxam or imidacloprid or fipronil Combinations are provided that include:

[0176] In one embodiment, a synergistic fungicidal combination for controlling saprophytic pathogenic fungi comprises: (i) ipconazole, (ii) thiabendazole, (iii) fluopyram, and (iv) one or more of flupirimine or flonicamid or chlorantraniliprole or cyantraniliprole or clothianidin or thiamethoxam or imidacloprid or fipronil Combinations are provided that include:

[0177] The active substances of the combination of the present invention can be applied simultaneously as tank mix, or can be applied successively or as formulations.Application can be carried out before plant emergence, either before or after planting stage, to soil.Application can be carried out as foliar spray, at different times during crop growth, either early or late after emergence, with one or two applications.More preferably, the combination of the present invention is applied to plant propagation material.

[0178] In some embodiments, combinations according to the present disclosure are used to treat plant propagation material.

[0179] In some embodiments, combinations according to the present disclosure are used to treat seeds, a type of plant propagation material.

[0180] The combinations of the present disclosure used to treat plant propagation material are effective in protecting the material and / or the plants derived therefrom during the life cycle of the target fungi that cause injury to the seeds or plants.

[0181] In one aspect, the present disclosure provides a fungicidal composition for controlling plant pathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a fungicidal composition comprising:

[0182] In one embodiment, the present disclosure provides a fungicide composition for controlling saprophytic phytopathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a fungicidal composition comprising:

[0183] In one embodiment, there is provided a synergistic fungicidal composition for controlling Rhizoctonia fungi, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; A fungicidal composition is provided comprising:

[0184] In one embodiment, the present disclosure provides a synergistic fungicidal composition for controlling the Sclerotinia sclerotiorum fungus, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a fungicidal composition comprising:

[0185] In one embodiment the disclosure provides a fungicidal composition for controlling plant pathogenic fungi comprising a demethylation inhibitor fungicide at a concentration in the range of 1% to 100% w / v of the composition, a β-tubulin assembly inhibitor fungicide at a concentration in the range of 1% to 100% w / v of the composition, and one or more pesticidally acceptable excipients at a concentration in the range of 1% to 50% w / v of the composition.

[0186] In an embodiment, the disclosure provides a fungicidal composition for controlling plant pathogenic fungi comprising a demethylation inhibitor fungicide at a concentration in the range of 1% to 80% w / v of the composition, a β-tubulin assembly inhibitor fungicide at a concentration in the range of 1% to 80% w / v of the composition, and one or more pesticidally acceptable excipients at a concentration in the range of 1% to 30% w / v of the composition.

[0187] In another embodiment, the demethylation inhibitor fungicide is selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole.

[0188] In a preferred embodiment, the demethylation inhibitor fungicide is ipconazole.

[0189] In another embodiment, the β-tubulin assembly inhibitor fungicide is selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl.

[0190] In a preferred embodiment, the β-tubulin assembly inhibitor fungicide is thiabendazole.

[0191] In one embodiment, the present disclosure provides a fungicidal composition for controlling plant pathogenic fungi comprising ipconazole, thiabendazole and one or more pesticidally acceptable excipients.

[0192] In one embodiment the disclosure provides a fungicidal composition for controlling a phytopathogenic fungus comprising ipconazole in a concentration ranging from 1% to 100% w / v of the composition, thiabendazole in a concentration ranging from 1% to 100% w / v of the composition, and one or more pesticidally acceptable excipients in a concentration ranging from 1% to 50% w / v of the composition.

[0193] In one embodiment the disclosure provides a fungicidal composition for controlling a phytopathogenic fungus comprising ipconazole in a concentration ranging from 1% to 80% w / v of the composition, thiabendazole in a concentration ranging from 1% to 80% w / v of the composition, and one or more pesticidally acceptable excipients in a concentration ranging from 1% to 30% w / v of the composition.

[0194] In one embodiment, the present disclosure provides a fungicidal composition for controlling saprophytic phytopathogenic fungi comprising ipconazole, thiabendazole and one or more pesticidally acceptable excipients.

[0195] In one embodiment there is provided a fungicidal composition for controlling Rhizoctonia spp., the composition comprising ipconazole, thiabendazole, and one or more pesticidally acceptable excipients.

[0196] In one embodiment there is provided a fungicidal composition for controlling Rhizoctonia solani, the composition comprising ipconazole, thiabendazole and one or more pesticidally acceptable excipients.

[0197] In one embodiment, the present disclosure provides a fungicidal composition for controlling Sclerotinia species, the composition comprising ipconazole, thiabendazole, and one or more pesticidally acceptable excipients.

[0198] In one embodiment, the present disclosure provides a fungicidal composition for controlling Sclerotinia sclerotiorum, the composition comprising ipconazole, thiabendazole, and one or more pesticidally acceptable excipients.

[0199] In one embodiment the disclosure provides a fungicidal composition for controlling a phytopathogenic fungus comprising ipconazole in a concentration ranging from 1% to 80% w / v of the composition, thiabendazole in a concentration ranging from 1% to 80% w / v of the composition, and one or more pesticidally acceptable excipients in a concentration ranging from 1% to 30% w / v of the composition.

[0200] The compositions used for treating seeds in the present disclosure may be in the form of soluble concentrates (SL, LS), dispersible concentrates (DC), emulsifiable concentrates (EC), suspensions (SC, OD, FS), emulsions (EW, EO, ES), slurries of particles in aqueous media (e.g. water), pastes, water-dispersible or water-soluble powders (WP, SP, SS, WS), pastilles, water-dispersible or water-soluble granules (WG, SG), dry granules (GR, FG, GG, MG), gel formulations (GF) and dusts (DP, DS). Water-soluble concentrates (LS), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC) and gels (GF) are commonly used for seed treatment purposes.

[0201] In one embodiment, the pesticidally acceptable excipient is selected from the group consisting of surfactants, antifreeze agents, wetting agents, antifoam agents, thickening agents, preservatives, colorants, fillers, and combinations thereof.

[0202] In a preferred embodiment, the composition is in the form of a suspension concentrate, a flowable concentrate or any suitable liquid formulation.

[0203] In one embodiment, the formulation comprises a nonionic surfactant and an anionic surfactant.

[0204] In an embodiment of the invention, the non-ionic surfactant is selected from the group comprising non-ionic surfactants such as polyalkylene oxide siloxanes, ethoxylated derivatives of fatty alcohols, alkyl glucosides, alkyl phenols, polyalkylene glycol ethers, and condensation products of alkyl phenols, amines, fatty acids, fatty acid esters, mono-, di- or triglycerides, alkylene oxides, such as ethylene oxide (EO) / propylene oxide (PO), various block copolymer surfactants derived from aliphatic amines or fatty acids and / or propylene oxide with ethylene oxide, such as ethoxylated alkylphenols or ethoxylated aryl or polyarylphenols, carboxylic acid esters solubilized with polyols or polyvinyl alcohol / polyvinyl acetate copolymers, polyvinyl alcohol, polyvinylpyrrolidone and acrylic acid graft copolymers and mixtures, reaction products and / or copolymers thereof.

[0205] In a preferred embodiment, the non-ionic surfactant of the surfactant mixture is selected from the group comprising non-ionic surfactants, for example alkylene oxides such as ethylene oxide / propylene oxide, aliphatic amines or fatty acids with ethylene oxide and / or propylene oxide such as ethoxylated alkylphenols or ethoxylated aryl or polyarylphenols, mixtures thereof, reaction products thereof, and / or various block copolymer surfactants derived from copolymers thereof.

[0206] In an embodiment, the composition comprises from about 0.1% to about 50% w / w, preferably from about 1% to about 40% w / w of a nonionic surfactant, based on the total weight of the pesticide composition.

[0207] In embodiments, the anionic surfactants include alkyl and aryl sulfates and sulfonates, such as sodium alkyl sulfates, sodium mono- and dialkylnaphthalene sulfonates, sodium α-olefin sulfonate, lignin and its derivatives (lignin sulfonates, sodium lignosulfonates), sodium alkanesulfonates, polyoxyalkyne alkyl ether sulfates, polyoxyalkylene alkyl ether sulfates, polyoxyalkylene styryl phenyl ether sulfates, mono- and di-alkylbenzene sulfonates, alkyl naphthalene sulfonates, alkyl naphthalene sulfonate formaldehyde condensates, alkyl diphenyl ether ... esters, olefin sulfonates, alkyl phosphates, polyoxyalkylene alkyl phosphates, polyoxyalkylene phenyl ether phosphates, polyoxyalkylphenol phosphates, polycarboxylates, fatty acids and their salts, alkyl glycinates, sulfonated methyl esters, sulfonated fatty acids, sulfosuccinates and their derivatives, acyl glutamates, acyl sarcosinates, alkyl sulfoacetates, acylated peptides, alkyl ether carboxylates, acyl lactates, anionic fluorosurfactants, ether sulfates, N-methyl fatty acid taurides, mixtures thereof, such as sodium, potassium, ammonium and amine salts, etc., or mixtures thereof.

[0208] In a preferred embodiment, the anionic surfactant is selected from the group comprising alkyl and aryl sulfates and sulfonates, such as sodium alkyl sulfates, sodium mono- and di-alkylnaphthalene sulfonates, lignin and its derivatives (such as lignosulfonates), polyoxyalkylene alkyl ether sulfates, alkylnaphthalene sulfonates, alkylnaphthalene sulfonate formaldehyde condensates.

[0209] In an embodiment, the composition comprises from about 0.1% to about 50% w / w, preferably from about 1% to about 40% w / w, of an anionic surfactant by total weight of the composition.

[0210] In embodiments, the compositions may further include one or more antifreeze agents, wetting agents, fillers, surfactants, anti-caking agents, pH adjusters, preservatives, biocides, antifoam agents, colorants, and other formulation aids.

[0211] In embodiments, the composition may further comprise one or more agriculturally acceptable excipients selected from the group consisting of surfactants, antifreeze agents, wetting agents, antifoaming agents, thickening agents, preservatives, colorants, fillers, and combinations thereof.

[0212] Suitable antifreeze agents which may be added to the agrochemical composition are liquid polyols, such as ethylene glycol, propylene glycol or glycerol.

[0213] Wetting agents that can be added to the pesticide composition of the present invention include, but are not limited to, polyarylalkoxylated phosphate esters and their potassium salts (e.g., Soprophor® FLK, Stepfac™ TSP PE-K). Other suitable wetting agents include sodium dioctyl sulfosuccinate (e.g., Geropon® SDS, Aerosol® OT) and ethoxylated alcohols (e.g., Trideceth-6, Rhodasurf® BC 610 and Tersperse® 4894).

[0214] Optionally, about 0.1% to about 5.0% w / w of an antiforming or defoamer is used to stop any unwanted foam generated during the manufacture of the concentrated liquid biocide dispersion composition. Preferred antifoaming agents are selected from the group of silicone-based compounds, alcohols, glycol ethers, mineral spirits, acetylenic diols, polysiloxanes, organosiloxanes, siloxane glycols, reaction products of silicon dioxide with organosiloxane polymers, polydimethylsiloxanes or polyalkylene glycols, alone or in combination. Suitable antifoaming agents include SAG™ Antifoams (e.g., SAG-10; SAG-1000AP; SAG-1529; SAG-1538; SAG-1571; SAG-1572; SAG-1575; SAG-2001; SAG-220; SAG-290; SAG-30; SAG-30E; SAG-330; SAG-47; SAG-5440; SAG-7133, and SAG-770).

[0215] Examples of thickeners based on anionic heteropolysaccharides belonging to the xanthan gum group are, inter alia, Rhodopol 23®, Rhodopol G®, Rhodopol 50 MD®, Rhodicare T®, Kelzan®, Kelzan S®, and Satiaxane CX91®.

[0216] The preservatives used can be benzoisothiazolinone (Proxel™ GXL) or phonol, 2-bromo-2-nitropropane-1,3-diol (Bioban™ BP 30), 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (Kathon™ CG / ICP), glutaraldehyde (Ucarcide™ 50), chloromethylisothiazolinone (CMIT) / methylisothiazolinone (MIT) (Isocil™ Ultra 1.5), 2.2-dibromo-3-nitrilopropioamide (Reputain™ D20), natamycin & Nisin, bronopol / CMIT / MIT (Mergal® 721K3).

[0217] Suitable colorants are preferably pigments that are poorly soluble in water and dyes that are water soluble, such as inorganic colorants such as iron oxide, titanium oxide, and iron hexacyanoferrate, and organic colorants such as alizarin, azo, and phthalocyanine colorants.

[0218] In one embodiment, the composition of the present disclosure is a seed treatment composition.

[0219] In one embodiment, the seed treatment composition is a suspension concentrate (SC), an emulsifiable concentrate (EC), a flowable concentrate, a flowable suspension (FS) microemulsion (ME), an oil dispersion (OD) and a suspoemulsion (SE).

[0220] In one embodiment, the present disclosure provides a seed treatment composition for controlling phytopathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a seed treatment composition comprising:

[0221] In one embodiment, the present disclosure provides a saprophytic seed treatment composition for controlling phytopathogenic fungi, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a seed treatment composition comprising:

[0222] In one embodiment, the present disclosure provides a seed treatment composition for controlling Rhizoctonia spp., comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a seed treatment composition comprising:

[0223] In one embodiment, the present disclosure provides a seed treatment composition for controlling Rhizoctonia solani, comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a seed treatment composition comprising:

[0224] In one embodiment, the present disclosure provides a seed treatment composition for controlling Sclerotinia spp., comprising: (i) at least one demethylation inhibitor fungicide; (ii) at least one β-tubulin assembly inhibitor fungicide, and (iii) one or more pesticidally acceptable excipients; The present invention provides a seed treatment composition comprising:

[0225] In one embodiment, the present disclosure provides a seed treatment composition for controlling Sclerotinia sclerotiorum fungus, comprising: (iv) at least one demethylation inhibitor fungicide; (v) at least one β-tubulin assembly inhibitor fungicide, and (vi) one or more pesticidally acceptable excipients. The present invention provides a seed treatment composition comprising:

[0226] In one embodiment the disclosure provides a seed treatment composition for controlling plant pathogenic fungi comprising a demethylation inhibitor fungicide at a concentration ranging from 1% to 100% w / v of the composition, a β-tubulin assembly inhibitor fungicide at a concentration ranging from 1% to 100% w / v of the composition, and an inert carrier at a concentration ranging from 1% to 50% w / v of the composition.

[0227] In one embodiment the disclosure provides a seed treatment composition for controlling plant pathogenic fungi comprising a demethylation inhibitor fungicide at a concentration ranging from 1% to 80% w / v of the composition, a β-tubulin assembly inhibitor fungicide at a concentration ranging from 1% to 80% w / v of the composition, and an inert carrier at a concentration ranging from 1% to 30% w / v of the composition.

[0228] In an embodiment, the present disclosure provides a seed treatment composition for controlling phytopathogenic fungi, the seed treatment composition comprising ipconazole, thiabendazole and one or more pesticidally acceptable excipients.

[0229] In one embodiment, the present disclosure provides a seed treatment composition for controlling saprophytic phytopathogenic fungi, the seed treatment composition comprising ipconazole, thiabendazole and one or more pesticidally acceptable excipients.

[0230] In one embodiment, the pesticidally acceptable excipient is selected from an adjuvant, a coating agent, or an inert carrier.

[0231] In one embodiment, the disclosure provides a seed treatment composition for controlling phytopathogenic fungi comprising ipconazole in a concentration range of 1% to 100% w / v of the composition, thiabendazole in a concentration range of 1% to 100% w / v of the composition, and a pesticidally acceptable excipient in a concentration range of 1% to 50% w / v of the composition.

[0232] In one embodiment, the disclosure provides a seed treatment composition for controlling phytopathogenic fungi comprising: ipconazole in a concentration range of 1% to 80% w / v of the composition; thiabendazole in a concentration range of 1% to 80% w / v of the composition; and a pesticidally acceptable excipient in a concentration range of 1% to 30% w / v of the composition.

[0233] In one embodiment, the disclosure provides a seed treatment composition for controlling plant pathogenic fungi comprising a fungicidal composition comprising ipconazole at a concentration ranging from 1% to 100% w / v of the composition, thiabendazole at a concentration ranging from 1% to 100% w / v of the composition, and an inert carrier at a concentration ranging from 1% to 50% w / v of the composition.

[0234] In one embodiment, the disclosure provides a seed treatment composition for controlling plant pathogenic fungi comprising: ipconazole at a concentration ranging from 1% to 80% w / v of the composition; thiabendazole at a concentration ranging from 1% to 80% w / v of the composition; and an inert carrier at a concentration ranging from 1% to 30% w / v of the composition.

[0235] In one embodiment there is provided a seed treatment composition for controlling Rhizoctonia spp., the seed treatment composition comprising ipconazole, thiabendazole and an inert carrier.

[0236] In one embodiment there is provided a seed treatment composition for controlling Rhizoctonia solani comprising ipconazole, thiabendazole and an inert carrier.

[0237] In one embodiment, the present disclosure provides a seed treatment composition for controlling Sclerotinia spp., the seed treatment composition comprising ipconazole, thiabendazole and an inert carrier.

[0238] In one embodiment, the disclosure provides a seed treatment composition for controlling Sclerotinia sclerotiorum, the composition comprising ipconazole, thiabendazole, and one or more pesticidally acceptable excipients.

[0239] The seed treatment composition according to the present invention comprises at least one inert carrier or adjuvant that is particularly useful for seed treatment.The inert carrier or adjuvant promotes adhesion and / or penetration of active ingredients into the seed layer and / or improves the stability of the composition and / or the manageability of the seeds treated with it.Therefore, the seed treatment composition according to the present invention comprises at least one adjuvant selected from coating agents, fillers, binders or plasticizers, or polymers.

[0240] Fillers may include organic or inorganic solid inert materials such as talc, clay, diatomaceous earth, magnesium aluminum silicate, white carbon black, pyrophyllite, precipitated calcium carbonate, high clay, organic bentonite, and the like, or mixtures thereof.

[0241] The filler may be an absorbent or inert carrier as known in the art and may include wood flour, grain flour, bark ground, wood and nut flour, sugars, especially polysaccharides, activated carbon, fine inorganic solids, silica gel, silicates, clays, chalk, diatomaceous earth, calcium carbonate, magnesium carbonate, dolomite, magnesium oxide, calcium sulfate, and the like. Clays and inorganic solids that may be used include calcium bentonite, kaolin, china clay, talc, perlite, mica, vermiculite, silicates, ground quartz, montmorillonite, attapulgite, boa, loess, limestone, lime, and mixtures thereof. Sugars that may be useful include dextrin and maltodextrin. Flours include wheat flour, oat flour, and barley flour. Fillers may also include fertilizer materials, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, and mixtures thereof.

[0242] The binder or polymer may be selected from the group consisting of polyesters, polyetheresters, polyanhydrides, polyesterurethanes, polyesteramides; polyvinyl acetates; polyvinyl acetate copolymers; polyvinyl alcohols and tyloses; polyvinyl alcohol copolymers; polyvinylpyrrolidones; starches, modified starches and starch derivatives, dextrins, maltodextrins, alginates, chitosans and celluloses, cellulose esters, cellulose ethers and cellulose esters including ethyl cellulose, methyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose and carboxymethyl cellulose. The polysaccharides may be selected from polysaccharides including ether esters; fats; oils; proteins including casein, gelatin and zein; gum arabic; shellac; vinylidene chloride and vinylidene chloride copolymers; lignosulfonates, especially calcium lignosulfonate; polyacrylates, polymethacrylates and acrylic copolymers; polyvinyl acrylate; polyethylene oxide; polybutene, polyisobutene, polystyrene, polyethyleneamine, polyethyleneamide; acrylamide based polymers and copolymers; polyhydroxyethyl acrylate, methylacrylamide monomer; and polychloroprene.

[0243] In one embodiment, the amount of the adjuvant does not exceed 10% by weight. Preferably, the amount of the adjuvant does not exceed 5% by weight and does not exceed 1% by weight, based on the total weight of the composition.

[0244] Further auxiliaries which may be present in the seed treatment composition include solvents, wetting agents, dispersing agents, emulsifiers, surfactants, thickeners, protective colloids, antifoaming agents and preservatives.

[0245] In one embodiment, the disclosure provides a seed treatment composition for controlling saprophytic phytopathogenic fungi comprising a fungicidal composition comprising ipconazole at a concentration ranging from 1% to 100% w / v of the composition, thiabendazole at a concentration ranging from 1% to 100% w / v of the composition, and an inert carrier at a concentration ranging from 1% to 50% w / v of the composition.

[0246] In one embodiment, the disclosure provides a seed treatment composition for controlling saprophytic phytopathogenic fungi comprising a fungicidal composition comprising ipconazole at a concentration ranging from 1% to 80% w / v of the composition, thiabendazole at a concentration ranging from 1% to 80% w / v of the composition, and an inert carrier at a concentration ranging from 1% to 30% w / v of the composition.

[0247] According to one embodiment of the present disclosure, there is provided a kit of parts comprising a fungicide composition, the kit comprising a plurality of components, each of which may comprise at least one of the components of the fungicide composition of the present disclosure.

[0248] One embodiment of the present invention discloses a kit of parts comprising a fungicide composition of a demethylation inhibitor, a β-tubulin assembly inhibitor fungicide and / or a pesticidally acceptable excipient.

[0249] One embodiment of the present invention discloses a kit-of-parts comprising ipconazole, thiabendazole and / or pesticidally acceptable excipients.

[0250] One or more of the components may be already combined or preformulated. In embodiments in which three or more components are provided in the kit, the components may be already combined and thus packaged in a single container, such as a vial, bottle, can, pouch, bag or canister.

[0251] The fungicide combination and composition of the present disclosure may be applied to the plant locus once or multiple times while the plant is growing. It may be applied to the planting locus before the seed is sown, during the seed sowing, before emergence and / or after emergence. The combination and composition may also be used while the plant is growing in a greenhouse, and may continue to be used after transplantation. The soil may be treated, for example, directly, before transplantation, at transplantation and / or after transplantation. The use of the composition may also be via any suitable method that ensures that the agent penetrates the soil, such as seedbed application, furrow application, soil drench, soil injection, drip irrigation, application via sprinkler or central pivot, introduction into the soil (broadcast or band), etc.

[0252] The rate and frequency of application of the compositions to the plants can vary within wide limits and will depend on the type of application, the particular active agent, the nature of the soil, the method of application (such as pre-emergence or post-emergence), the plant, the prevailing climatic conditions, and other factors governed by the method, time of application and the target plant.

[0253] The treatment of plants and plant parts with the active compound or compositions thereof according to the present disclosure is carried out by acting directly or in the surroundings, habitat or storage space using conventional treatment methods, for example by immersion, spraying, misting, irrigation, evaporation, dusting, misting, scattering, foaming, painting, spreading, watering (drenching), drip irrigation, and in the case of propagation material, especially seeds, also as dry seed treatment powders, seed treatment solutions, water-soluble powders for slurry treatment, by covering with husks, coating with one or more layers, etc. Furthermore, it is possible to apply the active compound in combination with other active substances by the ultra-low volume method, or to inject the active compound combination into the soil.

[0254] In an embodiment, when used in plant protection, the amount of active substance applied is in the range from 0.001 to 10 kg / ha, preferably from 0.001 to 5 kg / ha or from 0.001 to 2 kg / ha, preferably from 0.005 to 1 kg / ha, in particular from 0.005 to 0.5 kg / ha, depending on the type of effect desired.

[0255] The active substances of the combination of the present invention can be applied simultaneously as tank mix, or can be applied successively or as formulations.Application can be carried out before plant emergence, either before or after planting stage, to soil.Application can be carried out as foliar spray, at different times during crop growth, either early or late after emergence, with one or two applications.More preferably, the combination of the present invention is applied to plant propagation material.

[0256] In another embodiment, the seeds can be sprayed, coated or soaked. The process of coating the seeds refers to any process that partially or completely provides the outer surface of the seeds with one or more layers of the fungicide combination or composition of the present invention. According to this method, the seeds are washed and then coated with the diluted formulation for about a few minutes, for example by using a rotating pot mixer, followed by reversible rotation and then drying.

[0257] In an embodiment, coating of the plant or plant propagation material or seed may be done by any method known in the art.

[0258] In a preferred embodiment, the plants or plant propagation material or seeds are sown or planted in soil or in pots or beds.

[0259] In a preferred embodiment, sowing of the plants or plant propagation material or seeds is carried out by line sowing.

[0260] The seed treatment combinations may also contain further active compounds, which may be applied together and / or sequentially. These further compounds may be selected from fertilizers or micronutrient donors or other preparations that affect microorganisms or plant growth, such as inoculants (e.g. strains of nitrogen-fixing bacteria), plant inducers.

[0261] In embodiments, the methods of the present disclosure increase disease resistance in a plant or plant propagation material.

[0262] In an embodiment, the plant propagation material is a seed, rootstock or tuber.

[0263] In a preferred embodiment, the plant propagation material is a seed.

[0264] In a preferred embodiment, the plant propagation material of the crop is selected from the group consisting of brassicas (e.g., broccoli, Chinese cabbage, Brussels sprouts, cauliflower, Cavallo broccoli, kohlrabi, cabbage, Chinese cabbage and mustard greens); cilantro; coriander; corn; gourds such as chayote; wax gourd, citron melon, cucumber, gherkin, bottle gourd; muskmelon (e.g., cantaloupe, cassava, Crenshaw melon, golden pershaw melon, honeydew melon, honey ball, mango melon, Persian melon, pineapple melon, Santa Claus melon, and others). melon, snake melon, and watermelon); pumpkin, summer squash, winter squash, and watermelon; dried beans and peas, such as bean, field bean, kidney bean, lima bean, pinto bean, navy bean, tepari bean, adzuki bean, black eyed pea, cattle bean, cowpea, clouder pea, moss bean, mung bean, rice bean, southern pea, black gram, broad bean, chickpea, guar, hyacinth bean, lentil, field pea, and pigeon pea; eggplant; lettuce; broccoli raab, bok choy, collard, kale, mizuna, mustard spinach, rape green, and turnip green); okra; peppers; grass; soybeans; spinach; fleshy peas and peas such as peas, sunflowers, dwarf peas, edible snow peas, English peas, garden peas, green peas, snow peas, sugar snap peas, pigeon peas, kidney beans, broad beans, lima beans, runner beans, snap beans, wax beans, asparagus beans, yard long beans, jack beans, sword beans; tobacco; tomatoes; and tuber and corm vegetables such as potato, sweet potato, arracacha, arrowroot, bok choy, Jerusalem artichoke, edible canna, cassava, chayote, chufa, dasheen, ginger, lehren, tanier, turmel, yam beans, and true yams.

[0265] In an embodiment the seed is selected from the group of beans, field beans, kidney beans, lima beans, pinto beans, kidney beans, tepary beans, adzuki beans, field peas, soybeans, fleshy peas and peas, dwarf peas, edible snow peas, English peas, garden peas, green peas, snow peas, sugar snap peas, pigeon peas, kidney beans, broad beans, lima beans, runner beans, snap beans, wax beans.

[0266] In a preferred embodiment, the seeds may be selected from soybean seeds, orange seeds, rice seeds, raspberry seeds, broccoli seeds, prune seeds, corn seeds, peach seeds, mango seeds, celery seeds, conifer seeds, tangerine seeds, kiwi fruit seeds, gooseberry seeds, plum seeds, pumpkin seeds, beet seeds, star fruit seeds, bean seeds, asparagus seeds, apple seeds, crab apple seeds, Swiss chard seeds, and the like.

[0267] In embodiments, tubers include potatoes, carrots, parsnips, turnips, beet roots, sweet potatoes and taro.

[0268] In a preferred embodiment, the seeds are legumes including chickpeas, peanuts, black beans, green peas, lima beans, kidney beans, black-eyed peas, rapeseed and soybeans.

[0269] In a preferred embodiment, the seed is a soybean seed.

[0270] In another preferred embodiment, the seeds are selected from cereals.

[0271] In another embodiment, the seed is a row crop seed or an oil seed.

[0272] In an embodiment, the fungicide combination of the present invention comprising ipconazole and thiabendazole is applied to seeds and may be diluted or undiluted.

[0273] In an embodiment, the fungicide composition of the present invention comprising ipconazole and thiabendazole is applied to seeds and may be diluted or undiluted.

[0274] In an embodiment, the invention provides a method of controlling phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the weight ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:100 to 100:1.

[0275] In an embodiment, the invention provides a method for controlling phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the weight ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:10 to 10:1.

[0276] In an embodiment, the invention provides a method for controlling saprophytic phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a combination of a fungicide comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:10 to 10:1.

[0277] In an embodiment, the invention provides a method of controlling phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a combination of a fungicide comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is in the range of 1:5 to 5:1.

[0278] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a combination of a fungicide comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is 1:8.

[0279] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi in a plant, plant part or crop at the locus of plant propagation material comprising applying a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the ratio of demethylation inhibitor fungicide to β-tubulin assembly inhibitor fungicide is 1:6.

[0280] In an embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to the locus of a plant, plant part or plant propagation material a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:100 to 100:1.

[0281] In an embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to the locus of a plant, plant part or plant propagation material a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:10 to 10:1.

[0282] In an embodiment, the present invention provides a method for controlling saprophytic phytopathogenic fungi in crops comprising applying to the locus of a plant, plant part or plant propagation material a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:10 to 10:1.

[0283] In an embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to the locus of a plant, plant part or plant propagation material a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:5 to 5:1.

[0284] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying a combination comprising ipconazole and thiabendazole in a weight ratio of 1:8 to the locus of a plant, plant part or plant propagation material.

[0285] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying a combination comprising ipconazole and thiabendazole in a weight ratio of 1:6 to the locus of a plant, plant part or plant propagation material.

[0286] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to plant propagation material a combination comprising ipconazole, thiabendazole in a weight ratio ranging from 1:10 to 10:1.

[0287] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to seeds a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:10 to 10:1.

[0288] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to seeds a combination comprising ipconazole and thiabendazole in a weight ratio ranging from 1:5 to 5:1.

[0289] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to seeds a combination comprising ipconazole and thiabendazole in a weight ratio of 1:8.

[0290] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in a crop comprising applying to seeds a combination comprising ipconazole and thiabendazole in a weight ratio of 1:6.

[0291] In an embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising the steps of: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 50 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 100 g / 100 kg seed. and applying to a seed a combination comprising:

[0292] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (iii) demethylation inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 20 g / 100 kg seed, and (iv) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 80 g / 100 kg seed. and applying to a seed a combination comprising:

[0293] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 10 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 75 g / 100 kg seed. and applying to a seed a combination comprising:

[0294] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 8 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 70 g / 100 kg seed. and applying to a seed a combination comprising:

[0295] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 50 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 100 g / 100 kg of seeds and applying to a seed a combination comprising:

[0296] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds and applying to a seed a combination comprising:

[0297] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seed to 75 g / 100 kg of seed. and applying to a seed a combination comprising:

[0298] In another embodiment, the present invention provides a method for controlling phytopathogenic fungi in crop plants, comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds and applying to a seed a combination comprising:

[0299] The methods of controlling fungal infestations in crops using the combinations, fungicidal compositions and seed treatment compositions of the present invention provide synergistic control of the target plant pathogens.

[0300] In one embodiment, the present invention provides a method for the preparation of a soybean seed comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 50 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 100 g / 100 kg seed. and applying a fungicide combination comprising:

[0301] In one embodiment, the present invention provides a method for the preparation of a soybean seed comprising: (iii) demethylation inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 20 g / 100 kg seed, and (iv) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 80 g / 100 kg seed. and applying a fungicide combination comprising:

[0302] In another embodiment, the present invention provides a soybean seed comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 10 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 75 g / 100 kg seed. and applying a fungicide combination comprising:

[0303] In another embodiment, the present invention provides a soybean seed comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 8 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 70 g / 100 kg seed. and applying a fungicide combination comprising:

[0304] In another embodiment, the present invention provides a soybean seed comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 8 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 70 g / 100 kg seed. applying a fungicide combination comprising A method is provided which provides at least 70% synergistic control of plant pathogenic fungi.

[0305] In another embodiment, the present invention provides a soybean seed comprising: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 8 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg seed to 70 g / 100 kg seed. applying a fungicide combination comprising A method is provided which provides at least 80% synergistic control of plant pathogenic fungi.

[0306] In one embodiment, the present invention provides a method for the preparation of a soybean seed comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 50 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 100 g / 100 kg of seeds and applying a fungicide combination comprising:

[0307] In one embodiment, the present invention provides a method for the preparation of a soybean seed comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds and applying a fungicide combination comprising:

[0308] In another embodiment, the present invention provides a soybean seed comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds and applying a fungicide combination comprising:

[0309] In another embodiment, the present invention provides a soybean seed comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds and applying a fungicide combination comprising:

[0310] In one embodiment, the present invention provides a method for effectively controlling saprophytic phytopathogenic fungi comprising applying to soybean seeds a combination of fungicides comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 50 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 100 g / 100 kg of seeds The present invention provides a method comprising:

[0311] In one embodiment, the present invention provides a method for effectively controlling saprophytic phytopathogenic fungi comprising applying to soybean seeds a combination of fungicides comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds The present invention provides a method comprising:

[0312] In another embodiment, the present invention provides a method for effectively controlling saprophytic phytopathogenic fungi comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seed to 75 g / 100 kg of seed. The present invention provides a method comprising:

[0313] In another embodiment, the present invention provides a method for effectively controlling saprophytic phytopathogenic fungi comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds The present invention provides a method comprising:

[0314] In one embodiment, the present invention provides a method comprising applying to soybean seeds a combination of fungicides for effectively controlling Rhizoctonia solani, the combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 50 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 100 g / 100 kg of seeds The present invention provides a method comprising:

[0315] In one embodiment, the present invention provides a method comprising applying to soybean seeds a combination of fungicides for effectively controlling Rhizoctonia solani, the combination comprising: (iii) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (iv) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds. The present invention provides a method comprising:

[0316] In another embodiment, the present invention provides a method for effectively controlling Rhizoctonia solani comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seed to 75 g / 100 kg of seed. The present invention provides a method comprising:

[0317] In another embodiment, the present invention provides a method for effectively controlling Rhizoctonia solani comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds The present invention provides a method comprising:

[0318] In one embodiment, the present invention provides a method for effectively controlling Sclerotinia sclerotiorum comprising applying to soybean seeds a combination of fungicides comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 50 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 100 g / 100 kg of seeds The present invention provides a method comprising:

[0319] In one embodiment, the present invention provides a method for effectively controlling Sclerotinia sclerotiorum comprising applying to soybean seeds a combination of fungicides comprising: (iii) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (iv) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds. The present invention provides a method comprising:

[0320] In another embodiment, the present invention provides a method for effectively controlling Sclerotinia sclerotiorum comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seed to 75 g / 100 kg of seed. The present invention provides a method comprising:

[0321] In another embodiment, the present invention provides a method for effectively controlling Sclerotinia sclerotiorum comprising applying to soybean seeds a combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds The present invention provides a method comprising:

[0322] If the observed efficacy of a combination is greater than the expected efficacy, the combination is said to be "synergistic." Expected efficacy (E) is calculated using the following formula, also known as the Colby formula: E=(X+Y)-XY / 100

[0323] In the above formula, X is the potency of the demethylation inhibitor fungicide and Y is the potency of the β-tubulin assembly inhibitor fungicide.

[0324] In one embodiment the present invention relates to the use of a fungicide combination for controlling fungal infestations in crops, comprising the steps of: (i) a demethylation inhibitor fungicide at a rate ranging from 1 g / 100 kg seed to 20 g / 100 kg seed, and (ii) β-tubulin assembly inhibitor fungicides at application rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds Including, The use is provided, wherein the fungal infestation of the crop is caused by a saprophytic phytopathogenic fungus.

[0325] In one embodiment the present invention relates to the use of a fungicide combination for controlling fungal infestations in crops, comprising the steps of: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds Including, The use is provided, wherein the fungal infestation of the crop is caused by a saprophytic phytopathogenic fungus.

[0326] In one embodiment the present invention relates to the use of a fungicide combination for controlling fungal infestations in crops, comprising the steps of: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds Including, The use is provided, wherein the fungal infestation of the crop is caused by a saprophytic phytopathogenic fungus.

[0327] In one embodiment the present invention relates to the use of a fungicide combination for controlling fungal infestations in crops, comprising the steps of: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) Thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds Including, the fungal infestation of the crop is caused by a saprophytic phytopathogenic fungus, The use of the fungicide combination is suitable for seed treatment.

[0328] In another embodiment the present invention provides the use of a fungicide combination for controlling fungal infestations, the combination comprising ipconazole and thiabendazole for controlling fungal infestations caused by phytopathogenic saprophytic fungi in crops.

[0329] In another embodiment, the present invention provides the use of a combination of fungicides suitable for seed treatment.

[0330] In yet another embodiment, the combination of the present disclosure is used to treat soybean seeds.

[0331] In yet another embodiment, the fungicides in the combination according to the present disclosure are formulated together and applied pre- and / or post-emergence of the crop.

[0332] In yet another embodiment, the fungicides in the combination according to the present disclosure are formulated separately and applied sequentially.

[0333] In yet another embodiment, a fungicide combination according to the present disclosure is applied to the soil.

[0334] In yet another embodiment, the fungicide combination according to the present disclosure is applied to the soil immediately after sowing in an in-furrow treatment.

[0335] The combinations or compositions according to the present disclosure are effective in controlling plant diseases including:

[0336] Diseases in sorghum, e.g. leaf blight and leaf stripe Diseases in beans, e.g. leaf blight, spider blight and root rot Diseases of crinson clover, e.g. summer blight Diseases in Camphor seedlings, e.g. Southern blight Turfgrass diseases, such as brown patch and large patch Diseases in cabbage, such as: rot Diseases in lettuce, such as: bottom rot Diseases in buckwheat, e.g. damping-off Diseases in carrots, such as damping-off and crown rot Tulip diseases, such as leaf blight Diseases in radishes, such as root rot Diseases of edible burdock, such as black spot disease Konjac diseases, such as root rot Diseases in cereals, e.g. bear patch

[0337] Diseases in rice: Blast (Magnaporthe grisea), Southern leaf blight (Cochliobolus miyabeanus), Sheath blight (Rhizoctonia solani), and Bacaenae disease (Gibberella fujikuroi).

[0338] Diseases in wheat: e.g. powdery mildew (Erysiphe graminis), head blight (Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. recondita), pink snow mold (Micronectriella nivale), snow mold sclerotinia (Typhula species), Ustilago tritici, cattle smut (Tilletia caries), wheat eyespot (Pseudocercosporella herpotrichoides), leaf blight, (Mycosphaerella graminicola), wheat blast (Stagonospora nodorum), septilia, and wheat yellow spot (Pyrenophora tritici-repentis).

[0339] Barley diseases: Powdery mildew (Erysiphe graminis), Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale, Rust (Puccinia striiformis, P. graminis, P. hordei), Soft smut (Ustilago nuda), Scald (Rhynchosporium secalis), Net blotch (Pyrenophora teres), Leaf spot (Cochliobolus sativus), Stripe blight (Pyrenophora graminea), Rhizoctonia wilt (Rhizoctonia solani).

[0340] Diseases in maize: ear smut (Ustilago maydis), leaf spot (Cochliobolus heterostrophus), copper spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), grey leaf spot (Cercospora zeae-maydis), white spot (Phaeosphaeria mydis and / or Pantoea ananatis) and Rhizoctonia wilt (Rhizoctonia solani).

[0341] Citrus diseases: black spot (Diaporthe citri), scab (Elsinoe fawcetti), blue-green mold (Penicillium digitatum, P. italicum) and brown rot (Phytophthora parasitica, Phytophthora citrophthora).

[0342] Apple Diseases: Blossom bud blight (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Alternaria leaf spot, black spot (Venturia inaequalis), powdery mildew, bitter rot (Colletotrichum acutatum), neck rot (Phytophtora cactorum), brown spot (Diplocarpon mali), and apple ring spot (Botryosphaeria berengeriana).

[0343] Pear diseases: Black scab (Venturia nashicola, V.pirina), powdery mildew, black spot (Alternaria alternata Japanese pear pathotype), rust (Gymnosporangium haraeanum), and Phytophthora fruit rot (Phytophtora cactorum).

[0344] Peach diseases: Brown rot (Monilinia fructicola), powdery mildew, black spot (Cladosporium carpophilum), and Phomopsis rot (Phomopsis species).

[0345] Grape diseases: Anthracnose (Elsinoe ampelina), Ripe rot (Glomerella cingulata), Powdery mildew (Uncinula necator), Rust (Phakopsora ampelopsidis), Black rot (Guignardia bidwellii), Gray mold, and Downy mildew (Plasmopara viticola).

[0346] Persimmon diseases: anthracnose (Gloeosporium kaki), and leaf blight (Cercospora kaki, Mycosphaerella nawae).

[0347] Cucurbit diseases: Anthracnose (Colletotrichum lagenarium), Powdery mildew (Sphaerotheca fuliginea), Bitter gourd vine blight (Mycosphaerella melonis), Fusarium wilt (Fusarium oxysporum), Downy mildew (Pseudoperonospora cubensis), Phytophthora wilt (Phytophthora spp.), and damping off (Pythium spp.).

[0348] Tomato diseases: early blight (Alternaria solani), leaf mold (Cladosporium fulvum) and late blight (Phytophthora infestans), leaf blight and fruit rot.

[0349] Diseases of eggplant: Brown spot (Phomopsis vexans), powdery mildew (Erysiphe cichoracearum), leaf spot

[0350] Diseases of cruciferous vegetables: Alternaria leaf spot (Alternaria japonica), white spot (Cercosporella brassicae), clubroot (Plasmodiophora brassicae), and downy mildew (Peronospora parasitica), damping off.

[0351] Onion diseases such as rust (Puccinia allii) and downy mildew (Peronospora destructor).

[0352] Soybean diseases, such as purple spot (Cercospora kikuchii), black rot (Elsinoe glycines), cob rot (Diaporthe phaseolorum var. sojae), Septoria brown spot (Septoria glycines), frog spot (Cercospora sojina), rust (Phakopsora pachyrhizi), yellow rust, brown stem rot (Phytophthora sojae), and Rhizoctonia solani, leaf blight, wilt, and root rot.

[0353] Diseases of beans: Anthracnose (Colletotrichum lindemthianum). Diseases of groundnut: Spot (Cercospora personata), Brown spotted leaf (Cercospora arachidicola) and Southern blight (Sclerotium rolfsii).

[0354] Horticultural pea and pea diseases: powdery mildew (Erysiphe pisi), sclerotinia rot, root rot (Fusarium solani f.sp.pisi). Diseases in snap beans, e.g. black seed

[0355] Potato diseases: Early blight (Alternaria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), and powdery spot (Spongospora subterranean f.sp. subterranea), black spot, and stem / stolon canker and damping off.

[0356] Strawberry diseases: Powdery mildew (Sphaerotheca humuli), anthracnose (Glomerella cingulata).

[0357] Tea diseases: Exobasidium reticulatum, Elsinoe leucospila, gray blight (Pestalotiopsis species), and anthracnose (Colletotrichum theae sinensis).

[0358] Tobacco diseases: Brown spot (Alternaria longipes), Powdery mildew (Erysiphe cichoracearum), Anthracnose (Colletotrichum tabacum), Downy mildew (Peronospora tabacina), Anthracnose (Phytophthora nicotianae).

[0359] Rapeseed diseases: Sclerotinia sclerotiorum and Rhizoctonia solani. Cotton diseases: e.g. Rhizoctonia solani.

[0360] Sugar beet diseases: Cercospora leaf spot (Cercospora beticola), leaf blight (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris), and black root rot (Aphanomyces cochlioides).

[0361] Rose diseases: black spot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa), downy mildew (Peronospora sparsa). Chrysanthemum and Asteraceae diseases: downy mildew (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici), white rust (Puccinia horiana).

[0362] Diseases of various groups: diseases caused by Pythium species (Pythium aphanidermatum, Pythium debarianum, Pythium graminicola, Pythium irregulare, Pythium ultimum), gray mold (Botrytis cinerea) and sclerotinia sclerotiorum.

[0363] Radish diseases: Alternaria leaf spot (Alternaria brassicicola).

[0364] Turfgrass diseases: dollar spot (Sclerotinia homeocarpa), brown patch, and large patch (Rhizoctonia solani).

[0365] Banana diseases: Black sigutka (Mycosphaerella fijiensis), Yellow sigutka (Mycosphaerella musicola).

[0366] Sunflower diseases: Downy mildew (Plasmopara halstedii).

[0367] For example, seed diseases or diseases at the early stages of growth of various plants caused by Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp., and Diplodia spp.

[0368] A variety of plant viral diseases transmitted by Polymxa or Olpidium species.

[0369] The present invention provides a synergistic fungicide combination for effectively controlling fungal infestations in crops. The fungicide combination of the present invention effectively controls pathogenic saprophytic fungi in crops and reduces damage caused by fungal infestations.

[0370] In view of the above, it will be seen that the several advantages of the invention are achieved and other advantageous results attained.

[0371] Although the invention has been fully disclosed, it will be understood that numerous additional modifications and variations can be made without departing from the scope of the invention.

[0372] It will be understood that the specification and examples are illustrative but not limiting of the invention, and will suggest other embodiments to those skilled in the art that are within the spirit and scope of the disclosure. Other embodiments can be practiced that are also within the scope of the invention. The following examples illustrate the invention, but are not intended to limit the scope of the claims in any way. EXAMPLES

[0373] Example 1 Evaluation of the fungicidal effect of a combination of ipconazole and thiabendazole against Rhizoctonia solani

[0374] A method frequently used to improve the use profile of pesticides is the combination of an active compound with one or more other active compounds that contribute desired additional properties.However, when two or more active compounds are applied in combination, it is not uncommon for physical and biological incompatibility phenomena to occur, such as insufficient stability of the joint formulation, decomposition of the active compounds or antagonism of the active compounds.In contrast, what is desired is a combination of active compounds that has a favorable activity profile, high stability, and possibly synergistically enhanced activity, so that the application rate can be reduced compared to the individual application of the combined active compounds.

[0375] Chemical mixtures can show antagonism when mixed, in which case the results are lower than would be expected when the chemicals are combined. There can also be additive effects, in which the resulting mixture shows the results expected from the sum of its components. Finally, there can be synergy, in which the results are greater than expected. Synergistic results are rare and are typically only observed in results from high concentrations. In the highly regulated agrochemical industry, high concentrations are undesirable in the environment. Thus, when synergy is achieved at low doses, the resulting mixture is indeed a rare and unexpected discovery.

[0376] A synergistic effect of pesticides exists whenever the antiphytopathogenic activity of a combination of active compounds exceeds the sum of the activities of the active compounds when applied individually. The expected activity for a given combination of two active compounds can be calculated according to SR Colby ("Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 15, (1967), 20-22).

[0377] Colby Calculation: The efficacy of all treatments, as measured by the percentage reduction in the growth of the target plant pathogens, was assessed according to Colby's formula as follows:

[0378] if X is the percent inhibition of growth by ipconazole (A) at the application rate; Y is the percentage inhibition of growth by thiabendazole (B) at the applied dose; E is the predicted growth as a percentage of control with ipconazole and thiabendazole when active compounds A and B are applied at the rates At that time, Colby's formula is E=X+Y-XY / 100.

[0379] If the actual / observed antiphytopathogenic efficacy of the combination of ipconazole and thiabendazole against the growth of Rhizoctonia solani exceeds the calculated value, the activity of the combination is supraadditive, i.e. synergistic effects exist. In this case, the actual observed efficacy must be greater than the value of expected efficacy (E) calculated from the above formula.

[0380] Methods: An experiment was conducted to evaluate the biological efficacy of the disclosed inventive combination of ipconazole and thiabendazole against Rhizoctonia solani fungus on soybean seeds. Seeds were inoculated with Rhizoctonia solani. The fungicides were tank mixed and applied as seed treatments as listed in Table 4 below. Spray volume was 5ml / kg.

[0381] [Table 4]

[0382] The present combination of ipconazole and thiabendazole in its application for seed treatment is synergistic and provides effective control of the saprophytic Rhizoctonia solani fungus.

[0383] Example 2 Evaluation of the fungicidal effect of a combination of ipconazole and thiabendazole against Sclerotinia sclerotiorum

[0384] Colby calculation: The efficacy of all treatments, as measured by the percentage reduction in the growth of the target plant pathogen, was also evaluated according to Colby's formula as follows:

[0385] if X is the percent inhibition of growth by ipconazole (A) at the application rate; Y is the percentage inhibition of growth by thiabendazole (B) at the applied dose; E is the predicted growth as a percentage of control with ipconazole and thiabendazole when active compounds A and B are applied at the rates At that time, Colby's formula is E=X+Y-XY / 100.

[0386] If the actual / observed antiphytopathogenic efficacy of the combination of ipconazole and thiabendazole against the growth of S. sclerotiorum exceeds the calculated value, the activity of the combination is supraadditive, i.e., synergistic effects exist. In this case, the actual observed efficacy must be greater than the value of expected efficacy (E) calculated from the above formula.

[0387] Methods: A laboratory paper towel method was used to assess the incidence of the pathogen S. sclerotiorum in soybean seeds.

[0388] A paper towel was placed on a flat surface and moistened with water until thoroughly wet. A total of 100 soybean seeds in rows were placed on the sample-sized towel. The seeds were inoculated with a fungal pathogen. The seeds were pretreated according to the treatments listed in Table 5. A second towel was moistened and placed on the first paper towel, with the seeds remaining sandwiched between the two towels. It was observed that the air space between the two towels was maintained, but if not, excess water should be removed. The two towels were rolled with the seeds sandwiched between them and placed in a sealed container that retained moisture. The paper roll was upright and incubated in an incubator at 25°C for 14 days and with a 12-hour photoperiod, using plastic bags to maintain humidity during incubation. For each treatment, 400 seeds were analyzed with 8 replicates of 50 seeds each.

[0389] [Table 5]

[0390] The present combination of ipconazole and thiabendazole is synergistic when used as a seed treatment and provides effective control of saprophytic S. sclerotiorum.

Claims

1. 1. A fungicide combination for controlling fungal infestations in crops, comprising: (i) at least one demethylation inhibitor fungicide, and (ii) at least one β-tubulin assembly inhibitor fungicide. Including, A fungicide combination, wherein the ratio of said demethylation inhibitor fungicide to said β-tubulin assembly inhibitor fungicide is in the range of 1:10 to 10:

1.

2. (i) at least one demethylation inhibitor fungicide selected from one or more of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triazinol, triticonazole, and prothioconazole; and (ii) at least one β-tubulin assembly fungicide selected from one or more of benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, and thiophanate-methyl; 2. The fungicidal combination of claim 1 comprising:

3. 2. A fungicidal combination according to claim 1 comprising ipconazole and thiabendazole in a ratio ranging from 1:10 to 10:

1.

4. 4. A fungicidal combination according to claim 3 comprising ipconazole and thiabendazole in a ratio ranging from 1:10 to 10:1, said combination being suitable for seed treatment.

5. 5. A fungicidal combination according to claim 4 comprising ipconazole and thiabendazole in a ratio ranging from 1:10 to 10:1, said combination being suitable for controlling infestations of saprophytic phytopathogenic fungi in crops.

6. 5. The fungicidal combination of claim 4 comprising ipconazole and thiabendazole in a ratio of 1:

8.

7. 5. The fungicidal combination of claim 4 comprising ipconazole and thiabendazole in a ratio of 1:

6.

8. 2. A fungicidal combination according to claim 1, wherein ipconazole is in an amount ranging from 1 g / 100 kg seeds to 20 g / 100 kg seeds and thiabendazole is in an amount ranging from 1 g / 100 kg seeds to 80 g / 100 kg seeds.

9. 2. A fungicidal combination according to claim 1, wherein ipconazole is in an amount ranging from 1 g / 100 kg seeds to 10 g / 100 kg seeds and thiabendazole is in an amount ranging from 1 g / 100 kg seeds to 70 g / 100 kg seeds.

10. 10. A fungicide combination according to any one of claims 1 to 9, comprising an additional fungicide, herbicide or insecticide.

11. 1. A fungicidal composition for controlling fungal infestations comprising at least one demethylation inhibitor fungicide, at least one β-tubulin assembly inhibitor fungicide, and an agriculturally acceptable excipient, said composition being suitable for seed treatment.

12. 12. A fungicidal composition according to claim 11, wherein said composition comprises ipconazole, thiabendazole and an agriculturally acceptable excipient, said composition being suitable for seed treatment.

13. 12. A fungicidal composition according to claim 11, wherein said composition is a suspension concentrate (SC), an emulsion concentrate (EC), a flowable concentrate, a flowable suspension (FS) a microemulsion (ME), an oil dispersion (OD) and a suspoemulsion (SE).

14. A seed treatment composition for controlling fungal infestation comprising at least one demethylation inhibitor fungicide, at least one β-tubulin assembly inhibitor fungicide, and an inert carrier.

15. 15. The seed treatment composition of claim 14, wherein the composition comprises ipconazole, thiabendazole and an inert carrier.

16. 1. A method for controlling phytopathogenic fungi in a crop comprising applying a fungicide combination comprising at least one demethylation inhibitor fungicide and at least one β-tubulin assembly inhibitor fungicide, wherein the ratio of said demethylation inhibitor fungicide to said β-tubulin assembly inhibitor fungicide is in the range of 1:10 to 10:1, and is performed at the locus of a plant, plant part or plant propagation material.

17. 17. The method of claim 16, comprising applying to the locus of a plant, plant part or plant propagation material a fungicide combination comprising ipconazole and thiabendazole in a ratio ranging from 1:10 to 10:

1.

18. 20. The method of claim 17, comprising applying to the locus of a plant, plant part or plant propagation material a fungicide combination comprising ipconazole and thiabendazole in a ratio of 1:

8.

19. 20. The method of claim 17, comprising applying to the locus of a plant, plant part or plant propagation material a fungicide combination comprising ipconazole and thiabendazole in a ratio of 1:

6.

20. 17. The method of claim 16, wherein the plant propagation material is a seed, rhizome or tuber.

21. 21. The method of claim 17 or 20, comprising applying to the seed a fungicide combination comprising ipconazole and thiabendazole in a ratio in the range of 1:10 to 10:

1.

22. (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) thiabendazole at rates ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds 22. The method of claim 21 , comprising applying to the seed a fungicide combination comprising:

23. applying to the surface of a seed a combination of fungicides, said combination comprising: (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 10 g / 100 kg of seeds, and (ii) thiabendazole at rates ranging from 1 g / 100 kg of seeds to 75 g / 100 kg of seeds 22. The method of claim 21 , comprising:

24. (i) ipconazole at rates ranging from 1 g / 100 kg of seeds to 8 g / 100 kg of seeds, and (ii) thiabendazole at rates ranging from 1 g / 100 kg of seeds to 70 g / 100 kg of seeds 22. The method of claim 21, comprising applying to the surface of the seed a fungicide combination comprising:

25. 17. The method of claim 16, wherein the plant pathogenic fungi are Rhizoctonia solani and Sclerotinia sclerotiorum.

26. 21. The method of claim 20, wherein the seed is a cereal, legume, row crop or oil seed.

27. 21. The method of claim 20, wherein the seed is a soybean, corn, sunflower, or canola seed.

28. Use of a combination of fungicides to control fungal infestations in crops, said combination comprising: (i) ipconazole in an amount ranging from 1 g / 100 kg of seeds to 20 g / 100 kg of seeds, and (ii) thiabendazole in an amount ranging from 1 g / 100 kg of seeds to 80 g / 100 kg of seeds Including, The use, wherein said fungal infestation of crops is caused by phytopathogenic saprophytic fungi.

29. 29. Use according to claim 28, wherein the fungicide combination comprises ipconazole and thiabendazole for controlling fungal infestations caused by phytopathogenic saprophytic fungi in crops.

30. 29. The use according to claim 28, wherein the fungicide combination is suitable for seed treatment.

31. 29. The use according to claim 28, wherein the phytopathogenic fungi are Rhizoctonia solani and Sclerotinia Sclerotiorum.

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