Botanical sedative composition

Abstract

Disclosed herein is a topical composition that provides high environmental protection to skin, brightens skin complexion, and provides anti-aging benefits to skin.The topical composition comprises a vitamin C source, a copper source, one or more cannabinoid components, and sodium hyaluronate.Disclosed herein is also a method for administering the topical composition.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This invention claims priority to U.S. Provisional Patent Application No. 63 / 299,209, filed January 13, 2022, the entire contents of which are incorporated herein in their entirety.

[0002] The present invention relates to cosmetic compositions for skin care applications. [Background technology]

[0003] Excessive exposure to sunlight and other toxic free radical sources and irritants induces skin damage, resulting in various disfiguring skin conditions. Among these skin conditions, wrinkles, fine lines, loss of elasticity, sagging, dryness, and age spots are caused by sun damage and aging. Skin wrinkles are either deep grooves and creases or fine lines. Wrinkles can occur anywhere on the body, but especially where sun exposure is greatest, such as the face, neck, forearms, and hands.

[0004] It is known that free radicals from ultraviolet (UV) radiation increase with air pollution in populated areas, exacerbating the problem. Free radicals are destructive in that they hydrolyze elastin fibers in the skin and desynthesize collagen in the lower dermal layer of the skin, thereby causing wrinkles and other damaging skin conditions.

[0005] Nowadays, people often seek measures to prevent and / or combat the effects of aging and sun exposure. A variety of cosmetic compositions and homeopathic remedies are available to consumers who seek to achieve a more youthful, healthy appearance. However, there remains a need for topical compositions that provide effective treatment and prevention against skin photoaging and related skin disorders. Summary of the Invention

[0006] It is an object of certain embodiments of the present disclosure to provide topical compositions, methods of preparing said topical compositions, and methods of using said topical compositions to protect the skin against exogenous and endogenous aggressors that can deteriorate the youthful appearance of the skin.

[0007] The term "administering a topical composition" as used herein refers to topically applying onto the skin of a subject, for example, to the face, neck, hands, feet, elbows, knees, etc. As used herein, with respect to the disclosed topical formulations or the method of using the disclosed topical formulations, the terms "application", "applying" and "applying" refer to any manner of administering a topical formulation to skin, for example, human skin, such as the skin of a patient, that delivers the formulation to the skin surface of a subject in a medical or cosmetic procedure. Smearing, rubbing, spreading, spraying the disclosed topical formulation onto the skin of a subject, with or without the aid of a suitable device, are all included within the scope of the term "application" as used herein. With respect to administering or applying the disclosed skin care formulations, the term "topical" or "topically" refers to epicutaneous administration or application onto the skin. Application may be manual (e.g., directly by hand) or manipulated with an applicator, cloth, device, roll-on, wipe, unit dose sponge applicator, liquid applied with a swab or cotton ball, impregnated gauze or other substrate, coated silicone sheet or other sheet goods, coated bandage or external fixation device, moistened paper towels, individually wrapped cotton balls, transdermal delivery systems, etc. Administration may be self-administered or administered by a medical professional or caregiver.

[0008] In one embodiment of the present invention, the topical composition comprises a vitamin C source, a copper source, one or more cannabinoid components, and sodium hyaluronate.In another embodiment, the topical composition may comprise two or more of a vitamin C source, a copper source, one or more cannabinoid components, or sodium hyaluronate.In another embodiment, the topical composition may comprise three or more of a vitamin C source, a copper source, one or more cannabinoid components, or sodium hyaluronate.

[0009] In certain embodiments of the topical composition, the vitamin C source comprises ascorbic acid, tetrahexyldecyl ascorbate, or a combination thereof.

[0010] In certain embodiments of the topical composition, the copper source comprises copper PCA (pyrrolidone carboxylic acid), copper peptide, or a combination thereof.

[0011] In certain embodiments of the topical composition, the one or more cannabinoid components include hemp oil, refined cannabinoids, hemp seed oil, or a combination thereof.

[0012] In one embodiment, the topical composition further comprises a source of azelaic acid. The source of azelaic acid may include Azeloglycina.

[0013] In certain embodiments, the topical composition further comprises an adaptogen source. The adaptogen source comprises Resurgent Power BCR.

[0014] In certain embodiments, the topical composition further comprises an antioxidant system comprising green tea polyphenols.

[0015] In some embodiments, the topical composition further comprises one or more of the following: a solvent, a thickener, a chelating agent, vitamin D, a solubilizer, melatonin, a preservative, one or more plant extracts, a colorant, or a combination thereof.In certain embodiments, the topical composition may comprise a solvent comprising water, glycerin, or a combination thereof.In certain embodiments, the topical composition may comprise a thickener comprising a cellulose thickener, a synthetic polymer thickener, or a combination thereof.In certain embodiments, the topical composition may comprise a solubilizer having an HLB of greater than 6, preferably greater than 12.In certain embodiments, the topical composition may comprise one or more plant extracts selected from thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extract, or a combination thereof.

[0016] In certain embodiments, the topical composition may further comprise a plant-derived growth factor. In certain embodiments, the plant-derived growth factor may comprise a plant-derived synthetic human epidermal growth factor (EGF), a plant-derived synthetic vascular endothelial growth factor (VEGF), a plant-derived synthetic transforming growth factor (TGF), a plant-derived synthetic insulin growth factor (IGF), or a combination thereof.

[0017] In certain embodiments of the topical composition, the vitamin C source may be included in an amount of about 0.001 wt.% to about 20 wt.%, about 0.05 wt.% to about 10 wt.%, about 0.1 wt.% to about 5 wt.%, or about 1 wt.% to about 2.5 wt.%, based on the total weight of the topical composition.

[0018] In certain embodiments of the topical composition, the copper source may be included in an amount of about 0.001 wt.% to about 5 wt.%, about 0.05 wt.% to about 4 wt.%, about 0.1 wt.% to about 3 wt.%, or about 1 wt.% to about 2.5 wt.%, based on the total weight of the topical composition.

[0019] In some embodiments of the topical composition, the one or more cannabinoid components may be hemp oil. In some embodiments, the hemp oil may be present in an amount of about 0.001 wt.% to about 10 wt.%, about 0.05 wt.% to about 5 wt.%, about 0.1 wt.% to about 5 wt.%, or about 1 wt.% to about 2.5 wt.% based on the total weight of the topical composition.

[0020] In some embodiments of the topical composition, the one or more cannabinoid components may be purified cannabinoids. In some embodiments of the topical composition, the purified cannabinoid may be present in an amount of about 0.0001 wt.% to about 5 wt.%, about 0.001 wt.% to about 4 wt.%, about 0.01 wt.% to about 3 wt.%, about 0.1 wt.% to about 2.5 wt.%, or about 1 wt.% to about 1.75 wt.% based on the total weight of the topical composition.

[0021] In some embodiments of the topical composition, the one or more cannabinoid components may be hemp seed oil. In some embodiments, the hemp seed oil may be present in an amount of about 0.001 wt.% to about 10 wt.%, about 0.05 wt.% to about 5 wt.%, about 0.1 wt.% to about 5 wt.%, or about 1 wt.% to about 2.5 wt.% based on the total weight of the topical composition.

[0022] In some embodiments of the topical composition, sodium hyaluronate may be included in an amount of about 0.1 wt.% to about 5 wt.%, about 1 wt.% to about 4 wt.%, or about 2 wt.% to about 3 wt.%, based on the total weight of the topical composition.

[0023] In some embodiments of the topical composition, the thickening agent may be included in an amount of about 0 wt.% to about 3 wt.%, about 0.5 wt.% to about 2.5 wt.%, or about 1 wt.% to about 2 wt.%, based on the total weight of the topical composition.

[0024] In some embodiments of the topical composition, the solubilizer may be included in an amount of about 0 wt.% to about 10 wt.%, about 1 wt.% to about 9 wt.%, about 2 wt.% to about 8 wt.%, about 3 wt.% to about 7 wt.%, or about 4 wt.% to about 6 wt.%, based on the total weight of the topical composition.

[0025] In some embodiments of the topical composition, the one or more plant extracts may be thyme herb. In some embodiments, the thyme herb may be present in an amount of about 0 wt.% to about 10 wt.%, about 1 wt.% to about 9 wt.%, about 2 wt.% to about 8 wt.%, about 3 wt.% to about 7 wt.%, or about 4 wt.% to about 6 wt.%, based on the total weight of the topical composition.

[0026] In some embodiments of the topical composition, the one or more plant extracts may be mulberry extract. In some embodiments, the mulberry extract may be present in an amount of about 0 wt.% to about 10 wt.%, about 1 wt.% to about 9 wt.%, about 2 wt.% to about 8 wt.%, about 3 wt.% to about 7 wt.%, or about 4 wt.% to about 6 wt.%, based on the total weight of the topical composition.

[0027] In some embodiments of the topical composition, the one or more plant extracts can be elderberry, hi some embodiments, the elderberry can be present in an amount of about 0 wt.% to about 10 wt.%, about 1 wt.% to about 9 wt.%, about 2 wt.% to about 8 wt.%, about 3 wt.% to about 7 wt.%, or about 4 wt.% to about 6 wt.%, based on the total weight of the topical composition.

[0028] In some embodiments of the topical composition, the one or more plant extracts may be willow bark extract. In some embodiments, the willow bark extract may be present in an amount of about 0 wt.% to about 10 wt.%, about 1 wt.% to about 9 wt.%, about 2 wt.% to about 8 wt.%, about 3 wt.% to about 7 wt.%, or about 4 wt.% to about 6 wt.%, based on the total weight of the topical composition.

[0029] In some embodiments of the topical composition, the preservative may be phenoxyethanol. In some embodiments of the topical composition, the solvent may include glycerin and water. In some embodiments of the topical composition, the glycerin may be included in an amount of about 0 wt.% to about 20 wt.%, about 1 wt.% to about 15 wt.%, about 2 wt.% to about 12 wt.%, about 3 wt.% to about 10 wt.%, 4 wt.% to about 8 wt.%, or about 5 wt.% to about 7 wt.% based on the total weight of the topical composition.

[0030] In certain embodiments of the topical composition, melatonin may be included in an amount of about 0.001 wt.% to about 2 wt.%, about 0.01 wt.% to about 1 wt.%, or about 0.1 wt.% to about 0.5 wt.%, based on the total weight of the topical composition.

[0031] In certain embodiments, the topical composition further comprises allantoin. In some embodiments, the allantoin may be present in an amount of about 0 wt.% to about 2 wt.%, about 0.01 wt.% to about 1 wt.%, or about 0.1 wt.% to about 0.5 wt.%, based on the total weight of the topical composition.

[0032] In certain embodiments, the topical composition further comprises DL panthenol, which may be present in an amount of about 0 wt.% to about 5 wt.%, about 1 wt.% to about 4 wt.%, or about 2 wt.% to about 3 wt.%, based on the total weight of the topical composition.

[0033] In certain embodiments, the topical composition further comprises disodium EDTA, which may be present in an amount of about 0 wt.% to about 1 wt.%, about 0.001 wt.% to about 0.9 wt.%, about 0.01 wt.% to about 0.75 wt.%, or about 0.1 wt.% to about 0.5 wt.%, based on the total weight of the topical composition.

[0034] In certain embodiments, the topical composition further comprises a plant growth factor. In some embodiments, the plant growth factor may be included in an amount of about 0.1 wt.% to about 10 wt.%, about 0.5 wt.% to about 9 wt.%, about 1 wt.% to about 8 wt.%, about 2 wt.% to about 7 wt.%, about 3 wt.% to about 6 wt.%, or about 4 wt.% to about 5 wt.%, based on the total weight of the topical composition.

[0035] In another embodiment, a method of treating the skin comprises administering a topical composition to the skin.

[0036] In certain embodiments, the present disclosure is directed to a method of preparing any of the topical compositions described herein by combining an ascorbate component and greater than 0 wt% to about 1 wt% of an antioxidant system comprising green tea polyphenols. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0037] Unless otherwise stated, the following definitions are used.

[0038] The term "alkyl" as used herein refers to straight-chain and branched hydrocarbon groups. References to individual groups such as propyl include only the straight-chain group; branched-chain isomers such as isopropyl are specifically referenced.

[0039] The term "halo" or "halogen" as used herein refers to fluoro, chloro, bromo and iodo.

[0040] The term "carbocycle" or "carbocyclyl" refers to a single saturated (i.e., cycloalkyl) or single partially unsaturated (e.g., cycloalkenyl, cycloalkadienyl, etc.) ring (i.e., (C3-C7) carbocycle) having 3-7 carbon atoms. The term "carbocycle" or "carbocyclyl" also includes multiple condensed ring systems (e.g., ring systems containing 2, 3, or 4 carbocyclic rings). Thus, carbocycle includes polycyclic carbocycles having 7-12 carbon atoms as bicycles and up to about 20 carbon atoms as polycycles. Polycyclic carbocycles can be linked together through a single carbon atom to form a spiro linkage (e.g., spiropentane, spiro[4,5]decane, spiro[4.5]decane, etc.), through two adjacent carbon atoms to form a fused linkage, such as a bicyclo[4,5], [5,5], [5,6] or [6,6] system, or 9 or 10 ring atoms arranged as a bicyclo[5,6] or [6,6] system (e.g., decahydronaphthalene, norsabinane, norcarane), or through two non-adjacent carbon atoms to form a bridged linkage (e.g., norbornane, bicyclo[2.2.2]octane, etc.). A "carbocycle" or "carbocyclyl" may also be optionally substituted with one or more (e.g., 1, 2 or 3) oxo groups. Non-limiting examples of monocyclic carbocycles include cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopent-1-enyl, 1-cyclopent-2-enyl, 1-cyclopent-3-enyl, cyclohexyl, 1-cyclohex-1-enyl, 1-cyclohex-2-enyl, 1-cyclohex-3-enyl, and cycloheptyl.

[0041] The term "aryl" as used herein refers to a single aromatic ring or a multiple condensed ring system. For example, an aryl group can have 6-20 carbon atoms, 6-14 carbon atoms, or 6-12 carbon atoms. Aryl includes phenyl groups. Aryl also includes multiple condensed ring systems (e.g., ring systems containing 2, 3, or 4 rings) having about 9-20 carbon atoms, in which at least one ring is aromatic. Such multiple condensed ring systems may be optionally substituted with one or more (e.g., 1, 2, or 3) oxo groups at any carbocyclic portion of the multiple condensed ring system. It should be understood that the point of attachment of a multiple condensed ring system as defined above may be at any position of the ring system, including the aryl or carbocyclic portion of the ring. Exemplary aryl groups include, but are not limited to, phenyl, indenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, anthracenyl, and the like.

[0042] It will be recognized by those skilled in the art that compounds of the present invention having chiral centers can exist and be isolated in optically active and racemic forms. Some compounds may exhibit polymorphism. It should be understood that the present invention encompasses any racemic, optically active, polymorphic, or stereoisomeric form of the compounds of the present invention, or mixtures thereof, that have the useful properties described herein, and how to prepare optically active forms is well known in the art (e.g., by resolution of racemic forms by recrystallization techniques, by synthesis from optically active starting materials, by chiral synthesis, or by chromatographic separation using chiral stationary phases).

[0043] As used herein, "free or substantially free" refers to a topical composition that contains less than about 1 wt%, less than about 0.5 wt%, less than about 0.25 wt%, less than about 0.1 wt%, less than about 0.05 wt%, less than about 0.01 wt%, or 0 wt% of said ingredient.

[0044] As used herein, the term "phytosynthetic," when referring to growth factors, refers to botanical plants that have been bioengineered such that the botanical plant or an extract therefrom functions as a growth factor.

[0045] Topical Compositions According to various embodiments, the present disclosure relates to a topical composition comprising a continuous phase and a dispersed phase.The topical composition comprises an ascorbate component, a copper component and a cannabinoid component.In certain embodiments, the topical composition further comprises at least one additional cosmetically acceptable excipient.

[0046] The ascorbate component in any of the topical compositions described herein may comprise ascorbic acid or a derivative thereof, such as ascorbyl palmitate, sodium ascorbate, potassium ascorbate, ammonium ascorbate, triethanolamine ascorbate, ascorbyl or magnesium phosphate, ascorbyl polypeptides, ascorbyl glucosamine, ascorbic acid polymers, esters of ascorbic acid, amides of ascorbic acid, L-ascorbic acid, tetrahexyldecyl ascorbate, known as vitamin C, or other derivatives, or related compounds, including plant or herb extracts such as acerola extracts, citrus extracts, strawberry, etc., that may provide L-ascorbic acid or its derivatives. In certain embodiments, the ascorbate component in the topical composition comprises ascorbic acid, tetrahexyldecyl ascorbate, or a combination thereof.

[0047] The ascorbate component in any of the topical compositions described herein may be present in a concentration of from about 0.001 wt%, 0.01 wt%, 0.1 wt%, about 1 wt%, about 5 wt%, about 10 wt%, to about 12 wt%, about 15 wt%, about 18%, or about 20 wt%, based on the total weight of the topical composition. In certain embodiments, the ascorbate component is present in any of the topical compositions described herein in an amount ranging from about 0.001 wt% to about 20 wt%, about 0.05 wt% to about 10 wt%, about 0.1 wt% to about 5 wt%, or about 1 wt% to about 2.5 wt%, based on the total weight of the topical composition.

[0048] The copper component in any of the topical compositions described herein may include copper pyrrolidone carboxylic acid ("PCA"), a copper peptide, or a combination thereof.

[0049] The copper component in any of the topical compositions described herein may be present in a concentration of from about 0.001 wt%, about 0.01 wt%, about 0.1 wt%, about 1 wt%, to about 2 wt%, about 2.5 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, based on the total weight of the topical composition.

[0050] The cannabinoid component in any of the topical compositions described herein may include hemp oil, refined cannabinoids, hemp seed oil, cannabidiol, or a combination thereof.

[0051] In some embodiments, the cannabinoid component may include hemp oil, which may be present in a concentration of about 0.001 wt%, about 0.01 wt%, about 0.1 wt%, about 1 wt%, about 2.5 wt%, about 5 wt%, to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0052] In some embodiments, the cannabinoid component comprises a purified cannabinoid, which may be present in a concentration of about 0.0001 wt%, about 0.001 wt%, about 0.01 wt%, about 0.1 wt%, 1 wt%, up to about 1.75 wt%, about 2.5 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, based on the total weight of the topical composition.

[0053] In some compositions, the cannabinoid component may include hemp seed oil, which may be present in a concentration of about 0.001 wt%, about 0.01 wt%, about 0.1 wt%, about 1 wt%, about 2.5 wt%, about 5 wt%, to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0054] The sodium hyaluronate in the topical composition may be present in a concentration of from about 0.1 wt%, about 1 wt%, or about 2 wt%, up to about 3 wt%, 4 wt%, or 5 wt%, based on the total weight of the topical composition. The sodium hyaluronate in the topical composition may also be present in a concentration of from greater than 0 to about 5 wt%.

[0055] Certain plants, such as green tea, which is a bioflavonoid and consists of a high content of polyphenols with antioxidant properties, can be included in any of the topical compositions described herein.The antioxidant system in the topical compositions described herein can be present at a concentration of more than 0%, about 0.01 wt%, about 0.05 wt%, about 0.1 wt%, about 0.15 wt%, about 0.2 wt%, about 0.25 wt%, about 0.3 wt%, about 0.35 wt%, or about 0.4 wt%, to about 0.45 wt%, about 0.5 wt%, about 0.55 wt%, about 0.6 wt%, about 0.65 wt%, about 0.7 wt%, about 0.75 wt%, about 0.8 wt%, about 0.85 wt%, about 0.9 wt%, about 0.95 wt%, or about 1 wt%, based on the total weight of the topical composition.

[0056] In certain embodiments, the topical composition comprises an antioxidant system comprising any of the green tea polyphenols described herein in combination with at least one additional antioxidant.

[0057] In one embodiment, the additional antioxidants in the antioxidant system may be selected from the group of cinnamic acid, ferulic acid, caffeic acid, p-coumaric acid, sinapic acid, their cis and trans isomers, their salts, their equivalent derivatives, and combinations thereof. In another embodiment, the additional antioxidants in the antioxidant system (and in the topical composition overall) may be free or substantially free of cinnamic acid, ferulic acid, caffeic acid, p-coumaric acid, sinapic acid, their cis and trans isomers, their salts, their equivalent derivatives, and combinations thereof.

[0058] In certain embodiments, the additional antioxidant in the antioxidant system may be selected from the group of gallic acid, delphinidin, luteolin, quercetin, cyanidin, taxifolin, kaempferol, malvidin, hesperetin, pelargonidin, apigenin, naringenin, chrysin, ergothioneine, cis and trans isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof.

[0059] In certain embodiments, the additional antioxidant in the antioxidant system may be selected from the group of apigenin, ergothioneine, cis and trans isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof.

[0060] Each of the antioxidants in the antioxidant system may be present individually or cumulatively at a concentration of from greater than 0 wt%, about 0.01 wt%, about 0.05 wt%, about 0.1 wt%, about 0.15 wt%, about 0.2 wt%, about 0.25 wt%, about 0.3 wt%, about 0.35 wt%, or about 0.4 wt%, to about 0.45 wt%, about 0.5 wt%, about 0.55 wt%, about 0.6 wt%, about 0.65 wt%, about 0.7 wt%, about 0.75 wt%, about 0.8 wt%, about 0.85 wt%, about 0.9 wt%, about 0.95 wt%, or about 1 wt%, based on the total weight of the topical composition.

[0061] In certain embodiments, the antioxidant system comprises green tea polyphenols in an amount ranging from greater than 0 wt% to about 0.5 wt%, greater than 0 wt% to about 0.1 wt%, or greater than 0 wt% to about 0.01 wt%, based on the total weight of the topical composition.

[0062] In some embodiments, the topical composition comprises a source of azelaic acid. The source of azelaic acid can be azelogicina.

[0063] In some embodiments, the topical composition comprises an adaptogen source. The adaptogen source may comprise Resurgent Power BCR.

[0064] In some embodiments, the topical composition further comprises one or more of a solvent, a thickening agent, a chelating agent, vitamin D, a solubilizing agent, melatonin, a preservative, at least one botanical extract, or a colorant.

[0065] Suitable solvents that may be used in the topical compositions described herein include, but are not limited to, polysorbate 20, water, alkanediols (e.g., ethylene glycol, propylene glycol, butylene glycol), ethoxylated or propoxylated diglycols, ethanol, propanol, isopropanol, glycerin, methoxyisopropanol, PPG-2 methyl ether, PPG-3 methyl ether, propylene glycol butyl ether, PPG-2 butyl ether, phenoxyisopropanol, butoxyethanol, butoxydiglycol, methoxydiglycol, phenoxyethanol, PPG-3 butyl ether, PPG-2 propyl ether, propylene glycol propyl ether, or dipropylene glycol dimethyl ether, or mixtures thereof.

[0066] In certain embodiments, the solvent may be water, glycerin, or a combination thereof. In some embodiments, glycerin is present in an amount of about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 7 wt%, about 8 wt%, about 10 wt%, about 12%, about 15 wt%, or about 20 wt%, based on the total weight of the topical composition.

[0067] In certain embodiments, the thickener may include a cellulosic thickener, a synthetic polymeric thickener, or a combination thereof. The thickener may be included in the topical composition in any of the following amounts, based on the total weight of the topical composition: about 0 wt%, about 0.5 wt%, about 1 wt%, to about 2 wt%, about 2.5 wt%, or about 3 wt%.

[0068] In certain embodiments, the solubilizer may have an HLB of greater than 6, preferably greater than 12. The solubilizer may be included in the topical composition in any of the following amounts, from about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0069] In certain embodiments, the plant extract may be thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extract, or combinations thereof.

[0070] In some embodiments, the plant extract is thyme herb, which is present in an amount ranging from about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0071] In some embodiments, the plant extract is a mulberry extract, which is present in an amount ranging from about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0072] In some embodiments, the plant extract is elderberry, which is present in an amount ranging from about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0073] In some embodiments, the plant extract is willow bark extract, which is present in an amount of from about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt%, up to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%, based on the total weight of the topical composition.

[0074] In one particular embodiment, the preservative is phenoxyethanol.

[0075] In some embodiments, the topical composition further comprises melatonin, which may be present in an amount ranging from about 0.001 wt%, about 0.01 wt%, or about 0.1 wt%, to about 0.5 wt%, about 1 wt%, or about 2 wt%, based on the total weight of the topical composition.

[0076] In some embodiments, the topical composition further comprises allantoin, which may be present in an amount ranging from about 0.001 wt%, about 0.01 wt%, or about 0.1 wt%, to about 0.5 wt%, about 1 wt%, or about 2 wt%, based on the total weight of the topical composition.

[0077] In some embodiments, the topical composition further comprises DL panthenol, which may be present in any amount from about 0 wt%, about 1 wt%, or about 2 wt%, to about 3 wt%, about 4 wt%, or about 5 wt%, based on the total weight of the topical composition.

[0078] In some embodiments, the topical composition further comprises disodium EDTA, which may be present in an amount ranging from about 0 wt%, about 0.001 wt%, about 0.01 wt%, about 0.1 wt%, to about 0.5 wt%, about 0.75 wt%, about 0.9 wt%, or about 1 wt%, based on the total weight of the topical composition.

[0079] In some embodiments, the topical composition further comprises a plant growth factor. In some embodiments, the plant growth factor may comprise a plant synthetic human epidermal growth factor (EGF), a plant synthetic vascular endothelial growth factor (VEGF), a plant synthetic transforming growth factor (TGF), a plant synthetic insulin growth factor (IGF), or a combination thereof. For example, the plant growth factor may be Reneseed®, Epitensive®, Scelleye®, or a combination thereof (produced by Lipotrue). In some embodiments, the plant growth factor may be present in an amount of about 0.1 wt.% to about 10 wt.%, about 0.5 wt.% to about 9 wt.%, about 1 wt.% to about 8 wt.%, about 2 wt.% to about 7 wt.%, about 3 wt.% to about 6 wt.%, about 4 wt.% to about 5 wt.%, or about 1 wt.% to about 2 wt.% based on the total weight of the topical composition.

[0080] In certain embodiments, the topical composition further comprises a cosmetically acceptable excipient. Exemplary cosmetically acceptable excipients include, without limitation, epidermal penetration enhancers, solvents, mild surfactants, oil bodies, emulsifiers, pearlescent waxes, consistency regulators, thickeners, rheology modifiers, suspending agents, chelating agents, preservatives, superfatting agents, stabilizers, polymers, silicone or siloxane compounds, fats, waxes, lecithin, phospholipids, UV photoprotective agents, bioactive ingredients, additional antioxidants, deodorants, antiperspirants, antidandruff agents, film formers, bulking agents, insect repellents, self-tanning agents, tyrosinase inhibitors, hydrotropes, solubilizers, fragrance oils, pigments, zinc oxide, fatty alcohols, esters of fatty acids, adjuvants, natural or synthetic triglycerides including glyceryl esters and derivatives, hydrocarbon oils, superfatting agents, polymers, bioactive ingredients, hydrotropes, bacterial inhibitors, colorants, UV screening agents, agents that absorb UV light and provide photoprotection to the skin, or combinations thereof. In certain embodiments, the topical composition comprises a cosmetically acceptable excipient selected from the group of a solvent, an emulsifier, a consistency regulator, a thickener, a suspending agent, an additional antioxidant, a preservative, a balm, or a combination thereof. In certain embodiments, the topical composition is free or substantially free of silicone compounds.

[0081] In certain embodiments, the cosmetically acceptable excipient comprises glycerin in the topical composition in an amount of about 2 wt% to about 25 wt%, about 5 wt% to about 15 wt%, or about 8 wt% to about 12 wt%, based on the total weight of the topical composition.

[0082] In certain embodiments, the cosmetically acceptable excipient comprises water in the topical composition in an amount of about 5 wt% to about 95 wt%, about 10 wt% to about 95 wt%, about 20 wt% to about 80 wt%, about 35 wt% to about 70 wt%, or about 50 wt% to about 60 wt%, based on the total weight of the topical composition.

[0083] In certain embodiments, the cosmetically acceptable excipient comprises a viscosity agent. The viscosity agent may comprise xanthan gum, such as Keltrol Advanced Performance LAX-T. In certain embodiments, the cosmetically acceptable excipient comprises a chelating agent. Suitable chelating agents include, but are not limited to, disodium ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), N-(hydroxyethyl)-ethylenediaminetriacetic acid (HEDTA), tetrasodium glutamate diacetate (GLDA), and nitrilotriacetic acid (NTA).

[0084] How to use In some embodiments, the present disclosure is directed to a method for treating the skin of a subject for the effects of radical-induced damage.Radical-induced damage can include damage caused by free radicals from sunlight (UVB, UVA, visible light), HEV (blue) light, infrared (IR), pollution, irritants, allergens, and various environmental toxins, which are destructive to skin by hydrolyzing elastin fibers in skin and desynthesizing collagen in the lower dermis layer of skin. Exemplary radical-induced damage that may be treated, prevented, minimized, reduced, or attenuated following administration to the skin of a subject of an effective amount of any of the topical compositions described herein include, but are not limited to, skin wrinkling, the appearance of fine lines, rough skin, sagging skin, skin firmness, reduced skin elasticity, age spots, hyperpigmentation, scars, uneven skin surface, rosacea, acne, psoriasis, slowed skin renewal and metabolic processes, weathered appearance, yellowing, redness, dryness, ichthyosis, and other damaged skin conditions.

[0085] In certain embodiments, the present disclosure is directed to a method of lightening the skin of a subject by administering to the skin of the subject an effective amount of any of the topical compositions described herein, wherein the skin becomes lighter following administration of the topical composition.

[0086] In certain embodiments, the present disclosure is directed to a method of treating the skin of a subject for the effects of atmospheric aging by administering to the skin of the subject an effective amount of any of the topical compositions described herein, wherein the skin exhibits a reduction or attenuation of the effects of atmospheric aging following administration.

[0087] In certain embodiments, the present disclosure is directed to a treatment regimen method comprising administering an effective amount of any of the topical compositions described herein to the skin of a subject that has been subjected to a dermatological treatment. Dermatological treatments that may benefit from the subsequent (i.e., post-treatment) administration of the topical compositions described herein include, but are not limited to, non-ablative dermatological treatments, chemical peels, microablation, lasers, and the like. In certain embodiments, dermatological treatments that may benefit from the subsequent (i.e., post-treatment) administration of the topical compositions described herein include microdermabrasion, intense pulsed light (IPL), or non-ablative laser treatments. In certain embodiments, the methods described herein further comprise administering a dermatological treatment after administration of the topical composition and / or before administration of the topical composition, depending on the treatment regimen.

[0088] As used herein, the term "treatment" or "treating" in relation to a skin condition generally means "having a positive effect on a skin condition" and includes reducing, improving, and / or alleviating at least one symptom of the skin condition, reducing, improving, and / or alleviating the severity of the skin condition, or delaying, preventing, or inhibiting the progression of the skin condition. Thus, treatment, as used herein, does not require a complete cure of the condition. The formulations of the present disclosure useful for treating a skin condition or a method of treating a skin condition need only reduce the severity of the skin condition, reduce the severity of symptoms associated therewith, provide an improvement to the quality of life of the patient, or delay, prevent, or inhibit the onset of one or more symptoms of the skin condition. As used herein, these terms also include aesthetic improvements to the skin after application of the disclosed formulations having, for example, a combination of an ascorbate component and green tea polyphenols.

[0089] As used herein, the phrase "effective amount" refers to an amount of the topical composition of the present disclosure or components thereof effective to treat skin conditions as described above, including effects ranging from detectable local improvement in the area of ​​topical application to substantial relief of symptoms, improvements in one or more aesthetic criteria including, but not limited to, perceived improvements in free radical damage from sunlight (UVB, UVA, visible light), HEV (blue) light, infrared (IR), pollution, irritants, allergens, and various environmental toxins, skin wrinkling, the appearance of fine lines, rough skin, sagging skin, skin firmness, skin elasticity, age spots, hyperpigmentation, scars, uneven skin surface, rosacea, acne, psoriasis, skin renewal and metabolism processes, weathered appearance, yellowing, redness, dryness, ichthyosis, and other damaged skin conditions.

[0090] Effective amount varies according to the specific condition or condition to be treated, the severity of the condition, the duration of treatment, the specific components of the composition used, and other factors.In certain embodiments, the topical composition described herein is suitable for administration by frequent regular application, such as by application once, twice, three times, or four times or more per day, for a duration of at least 1 day, at least 3 days, at least 5 days, at least 7 days, at least 10 days, at least 14 days, at least 21 days, at least 30 days, etc.Therefore, in certain embodiments, the method described herein further comprises repeating the administration of the topical composition periodically.

[0091] In certain embodiments, the topical compositions described herein are suitable for pre- or post-treatment administration, such as before or after a dermatological treatment.

[0092] In certain embodiments, the topical composition described herein is an emulsion of aqueous and oily phases, so that the two phases may separate during storage.Therefore, in certain embodiments, the method described herein further comprises shaking the topical composition to uniformly disperse the oily phase in the aqueous phase before administration.

[0093] Preparation method The present disclosure is also directed to a method of preparing any of the topical compositions described herein, the method comprising combining an ascorbate component, greater than 0 wt% to about 1 wt% of an antioxidant system including green tea polyphenols, and optionally at least one cosmetically acceptable excipient to produce any of the topical compositions described herein.

[0094] Topical compositions may be formulated into serums, gels, lotions, creams, pad-on formulations, and the like. EXAMPLES

[0095] The following examples are presented to aid in the understanding of the invention and, of course, should not be construed as specifically limiting the invention described and claimed herein. Such variations of the invention, including the substitution of all currently known or later developed equivalents that are within the scope of one skilled in the art, and slight modifications of formulations or experimental designs, should be considered to fall within the scope of the invention incorporated herein.

[0096] [Example 1] Topical compositions according to embodiments described herein were formulated into serums having the compositions set forth below in Table 1. The serums were emulsions of an aqueous phase and an oily phase and had a pH ranging from about 2.5 to about 3.5.

[0097] [Table 1]

[0098] For ease of explanation, embodiments of the methods of this disclosure are shown and described as a series of acts. However, acts according to this disclosure may occur in various orders and / or simultaneously, with other acts not shown and described herein. Moreover, not all illustrated acts may be required to perform a methodology in accordance with the disclosed subject matter. In addition, those skilled in the art will understand and appreciate that a methodology may alternatively be represented as a series of interrelated states via a state diagram or events.

[0099] In the foregoing description, numerous specific details are set forth, such as specific materials, dimensions, process parameters, etc., to provide a thorough understanding of the present invention. Particular features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments. The word "example" or "exemplary" is used herein to mean serving as an example, instance, or illustration. Any aspect or design described herein as "example" or "exemplary" should not necessarily be construed as preferred or advantageous over other aspects or designs. Rather, use of the word "example" or "exemplary" is intended to present concepts in a specific manner. As used in this application, the term "or" is intended to mean an inclusive "or" rather than an exclusive "or." That is, unless otherwise specified or clear from the context, "X includes A or B" is intended to mean any of the natural inclusive permutations. That is, if X includes A, X includes B, or X includes both A and B, then "X includes A or B" is satisfied in any of the foregoing cases. In addition, the articles "a" and "an" as used in this application and the appended claims should be construed generally to mean "one or more" unless otherwise specified or unless the singular form is clearly intended from the context. References throughout this specification to "an embodiment," "a particular embodiment," or "one embodiment" mean that the particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, appearances of the phrases "an embodiment," "a particular embodiment," or "one embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment.

[0100] References to numerical ranges throughout this specification should not be construed as limiting, but should be understood to include the outer limits of the ranges, as well as each number and / or narrower range within the recited numerical ranges.

[0101] The term "about" when referring to a physical quantity should be understood to include a measurement error within 10%, including 10%. For example, "about 100°C" should be understood to mean "100±10°C."

[0102] The present invention has been described with reference to certain exemplary embodiments thereof. Accordingly, the specification and drawings are to be regarded in an illustrative rather than a restrictive sense. Various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art and are intended to fall within the scope of the appended claims.

Claims

1. Vitamin C source, copper source, one or more cannabinoid components, and Sodium hyaluronate 1. A topical composition comprising:

2. 10. The topical composition of claim 1, wherein the vitamin C source comprises ascorbic acid, tetrahexyldecyl ascorbate, or a combination thereof.

3. 10. The topical composition of claim 1, wherein the copper source comprises copper PCA (pyrrolidone carboxylic acid), copper peptide, or a combination thereof.

4. 10. The topical composition of claim 1, wherein the one or more cannabinoid components comprise hemp oil, purified cannabinoids, hemp seed oil, or a combination thereof.

5. The topical composition of claim 1 , further comprising a source of azelaic acid.

6. 6. The topical composition of claim 5, wherein the source of azelaic acid comprises azeloglycina.

7. The topical composition of claim 1 further comprising an adaptogen.

8. 8. The topical composition of claim 7, wherein the adaptogen source comprises Resurgent Power BCR.

9. 10. The topical composition of claim 1, further comprising an antioxidant system comprising green tea polyphenols.

10. 10. The topical composition of claim 1, further comprising one or more of a solvent, a thickening agent, a chelating agent, vitamin D, a solubilizing agent, melatonin, a preservative, one or more botanical extracts, a colorant, or a combination thereof.

11. The topical composition of claim 10 comprising a solvent comprising water, glycerin, or a combination thereof.

12. 11. The topical composition of claim 10, comprising a thickener comprising a cellulosic thickener, a synthetic polymeric thickener, or a combination thereof.

13. 11. The topical composition of claim 10, comprising a solubilizer having an HLB greater than 6, preferably greater than 12.

14. 11. The topical composition of claim 10, comprising one or more plant extracts selected from thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extract, or combinations thereof.

15. 10. The topical composition of claim 1, wherein the vitamin C source is included in an amount of 0.001 wt.% to 20 wt.%, 0.05 wt.% to 10 wt.%, 0.1 wt.% to 5 wt.%, or 1 wt.% to 2.5 wt.%, based on the total weight of the topical composition.

16. 10. The topical composition of claim 1, wherein the copper source is included in an amount of 0.001 wt. % to 5 wt. %, 0.05 wt. % to 4 wt. %, 0.1 wt. % to 3 wt. %, or 1 wt. % to 2.5 wt. %, based on the total weight of the topical composition.

17. 5. The topical composition of claim 4, wherein the one or more cannabinoid components is hemp oil.

18. 18. The topical composition of claim 17, wherein the hemp oil is present in an amount of 0.001 wt.% to 10 wt.%, 0.05 wt.% to 5 wt.%, 0.1 wt.% to 5 wt.%, or 1 wt.% to 2.5 wt.%, based on the total weight of the topical composition.

19. 5. The topical composition of claim 4, wherein the one or more cannabinoid components are purified cannabinoids.

20. 20. The topical composition of claim 19, wherein the purified cannabinoid is present in an amount of 0.0001 wt.% to 5 wt.%, 0.001 wt.% to 4 wt.%, 0.01 wt.% to 3 wt.%, 0.1 wt.% to 2.5 wt.%, or 1 wt.% to 1.75 wt.%, based on the total weight of the topical composition.

21. 5. The topical composition of claim 4, wherein the one or more cannabinoid components is hemp seed oil.

22. 22. The topical composition of claim 21, wherein the hemp seed oil is present in an amount of 0.001 wt.% to 10 wt.%, 0.05 wt.% to 5 wt.%, 0.1 wt.% to 5 wt.%, or 1 wt.% to 2.5 wt.%, based on the total weight of the topical composition.

23. 10. The topical composition of claim 1, wherein the sodium hyaluronate is present in an amount of 0.1 wt. % to 5 wt. %, 1 wt. % to 4 wt. %, or 2 wt. % to 3 wt. %, based on the total weight of the topical composition.

24. 13. The topical composition of claim 12, wherein the thickener is present in an amount of 0 wt. % to 3 wt. %, 0.5 wt. % to 2.5 wt. %, or 1 wt. % to 2 wt. %, based on the total weight of the topical composition.

25. 14. The topical composition of claim 13, wherein the solubilizing agent is present in an amount of 0 wt.% to 10 wt.%, 1 wt.% to 9 wt.%, 2 wt.% to 8 wt.%, 3 wt.% to 7 wt.%, or 4 wt.% to 6 wt.%, based on the total weight of the topical composition.

26. 15. The topical composition of claim 14, wherein the one or more plant extracts is thyme herb.

27. 27. The topical composition of claim 26, wherein the thyme herb is included in an amount of 0 wt.% to 10 wt.%, 1 wt.% to 9 wt.%, 2 wt.% to 8 wt.%, 3 wt.% to 7 wt.%, or 4 wt.% to 6 wt.%, based on the total weight of the topical composition.

28. 15. The topical composition of claim 14, wherein the one or more plant extracts is a mulberry fruit extract.

29. 29. The topical composition of claim 28, wherein the mulberry fruit extract is included in an amount of 0 wt.% to 10 wt.%, 1 wt.% to 9 wt.%, 2 wt.% to 8 wt.%, 3 wt.% to 7 wt.%, or 4 wt.% to 6 wt.%, based on the total weight of the topical composition.

30. 15. The topical composition of claim 14, wherein the one or more plant extracts is elderberry.

31. 31. The topical composition of claim 30, wherein the elderberry is present in an amount of 0 wt.% to 10 wt.%, 1 wt.% to 9 wt.%, 2 wt.% to 8 wt.%, 3 wt.% to 7 wt.%, or 4 wt.% to 6 wt.%, based on the total weight of the topical composition.

32. 15. The topical composition of claim 14, wherein the one or more plant extracts is willow bark extract.

33. 33. The topical composition of claim 32, wherein the willow bark extract is included in an amount of 0 wt.% to 10 wt.%, 1 wt.% to 9 wt.%, 2 wt.% to 8 wt.%, 3 wt.% to 7 wt.%, or 4 wt.% to 6 wt.%, based on the total weight of the topical composition.

34. 11. The topical composition of claim 10, wherein the preservative is phenoxyethanol.

35. The topical composition of claim 11 , wherein the solvent comprises glycerin and water.

36. 36. The topical composition of claim 35, wherein glycerin is included in an amount of 0 wt.% to 20 wt.%, 1 wt.% to 15 wt.%, 2 wt.% to 12 wt.%, 3 wt.% to 10 wt.%, 4 wt.% to 8 wt.%, or 5 wt.% to 7 wt.%, based on the total weight of the topical composition.

37. 11. The topical composition of claim 10, wherein the melatonin is included in an amount of 0.001 wt. % to 2 wt. %, 0.01 wt. % to 1 wt. %, or 0.1 wt. % to 0.5 wt. %, based on the total weight of the topical composition.

38. 10. The topical composition of claim 1, further comprising allantoin.

39. 39. The topical composition of claim 38, wherein allantoin is included in an amount of 0 wt. % to 2 wt. %, 0.01 wt. % to 1 wt. %, or 0.1 wt. % to 0.5 wt. %, based on the total weight of the topical composition.

40. 10. The topical composition of claim 1, further comprising DL panthenol.

41. 41. The topical composition of claim 40, wherein DL panthenol is included in an amount of 0 wt. % to 5 wt. %, 1 wt. % to 4 wt. %, or 2 wt. % to 3 wt. %, based on the total weight of the topical composition.

42. 10. The topical composition of claim 1, further comprising disodium EDTA.

43. 43. The topical composition of claim 42, wherein disodium EDTA is included in an amount of 0 wt. % to 1 wt. %, 0.001 wt. % to 0.9 wt. %, 0.01 wt. % to 0.75 wt. %, or 0.1 wt. % to 0.5 wt. %, based on the total weight of the topical composition.

44. The topical composition of claim 1 further comprising a plant growth factor.

45. 45. The topical composition of claim 44, wherein the plant growth factor comprises a synthetic plant human epidermal growth factor (EGF), a synthetic plant vascular endothelial growth factor (VEGF), a synthetic plant transforming growth factor (TGF), a synthetic plant insulin growth factor (IGF), or a combination thereof.

46. 45. The topical composition of claim 44, wherein the plant growth factor is included in an amount of 0.1 wt.% to 10 wt.%, 0.5 wt.% to 9 wt.%, 1 wt.% to 8 wt.%, 2 wt.% to 7 wt.%, 3 wt.% to 6 wt.%, or 4 wt.% to 5 wt.%, based on the total weight of the topical composition.

47. 47. A topical composition according to any one of claims 1 to 46 for treating skin.