New heterocyclic compounds

Abstract

The present invention relates to general formula (I) TIFF2025504522000834.tif32161 (In the formula, A and R 1 ~R 4 The present invention provides a novel heterocyclic compound having (as described herein), a composition comprising the compound, a method for producing the compound, and a method for using the compound.

Description

[Technical Field]

[0001] The present invention relates to organic compounds useful for the treatment or prevention in mammals, in particular monoacylglycerol lipase (MAGL) inhibitors for the treatment or prevention of neuroinflammation, neurodegenerative diseases, pain, cancer, psychiatric disorders, multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, inflammatory bowel disease, abdominal pain, abdominal pain associated with irritable bowel syndrome, and / or visceral pain in mammals. [Background technology]

[0002] Endocannabinoids (ECs) are signaling lipids that exert their biological effects by interacting with cannabinoid receptors (CB1 and CB2). They regulate multiple physiological processes, including neuroinflammation, neurodegeneration, and tissue regeneration (Iannotti, FA, et al., Progress in lipid research 2016, 62, 107-28). In the brain, the main endocannabinoid, 2-arachidonoylglycerol (2-AG), is produced by diacylglycerol lipase (DAGL) and hydrolyzed by monoacylglycerol lipase MAGL. MAGL hydrolyzes 85% of 2-AG, while the remaining 15% is hydrolyzed by ABHD6 and ABDH12 (Nomura, DK, et al., Science 2011, 334, 809). MAGL is expressed throughout the brain and in most brain cell types, including neurons, astrocytes, oligodendrocytes, and microglial cells (Chanda, P.K., et al., Molecular Pharmacology 2010, 78, 996; Viader, A., et al., Cell Reports 2015, 12, 798). Hydrolysis of 2-AG leads to the formation of arachidonic acid (AA), a precursor of prostaglandins (PGs) and leukotrienes (LTs). AA oxidative metabolism is increased in inflamed tissues. Two major enzymatic pathways for arachidonic acid oxidation involved in the inflammatory process are cyclooxygenase, which produces PGs, and 5-lipoxygenase, which produces LTs. Among the various cyclooxygenase products formed during inflammation, PGE2 is one of the most important. These products have been detected at sites of inflammation, for example, in the cerebrospinal fluid of patients with neurodegenerative disorders, and are thought to contribute to the inflammatory response and disease progression. Mice lacking MAGL (Mgll- / -) exhibit a dramatic reduction in 2-AG hydrolase activity and a dramatic increase in 2-AG levels in the nervous system, whereas other arachidonoyl-containing phospholipids and neutral lipid species, including anandamide (AEA), and other free fatty acids, are unchanged.Conversely, levels of AA and AA-derived prostaglandins, as well as other eicosanoids including prostaglandins E2 (PGE2), D2 (PGD2), and F2 (PGF2), and thromboxane B2 (TXB2), are greatly reduced. Although the phospholipase A2 (PLA2) enzyme has been considered the major source of AA, cPLA2-deficient mice have unchanged AA levels in their brains, highlighting the importance of MAGL's role in regulating AA production and brain inflammatory processes.

[0003] Neuroinflammation is a common pathological feature of brain diseases, including, but not limited to, neurodegenerative diseases (e.g., multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, and psychiatric disorders such as anxiety and migraine). In the brain, the production of eicosanoids and prostaglandins regulates the neuroinflammatory process. The inflammatory progenitor lipopolysaccharide (LPS) produces a robust, time-dependent increase in brain eicosanoids that is significantly blunted in Mgll- / - mice. LPS treatment also induces a widespread increase in inflammatory cytokines, including interleukin-1-a (IL-1-a), IL-1b, IL-6, and tumor necrosis factor-a (TNF-a), which are suppressed in Mgll- / - mice.

[0004] Neuroinflammation is characterized by the activation of innate immune cells in the central nervous system, microglia, and astrocytes. Anti-inflammatory drugs have been shown to suppress glial cell activation and disease progression in preclinical models, including Alzheimer's disease and multiple sclerosis (Lleo A., Cell Mol Life Sci 2007, 64, 1403). Importantly, genetic and / or pharmacological disruption of MAGL activity also inhibits LPS-induced activation of microglial cells in the brain (Nomura, DK, et al., Science 2011, 334, 809).

[0005] Furthermore, genetic and / or pharmacological disruption of MAGL activity has been shown to be protective in several animal models of neurodegeneration, including, but not limited to, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. For example, irreversible MAGL inhibitors have been widely used in preclinical models of neuroinflammation and neurodegeneration (Long, JZ, et al., Nature Chemical Biology 2009, 5, 37). Systemic injection of such inhibitors recapitulates the Mgll- / - mouse phenotype in the brain, including increased 2-AG levels, decreased AA levels and related eicosanoid production, and suppression of cytokine production and microglial activation after LPS-induced neuroinflammation (Nomura, DK, et al., Science 2011, 334, 809), confirming MAGL as a druggable target.

[0006] Following genetic and / or pharmacological disruption of MAGL activity, endogenous levels of 2-AG, a natural MAGL substrate, increase in the brain. 2-AG has been reported to have beneficial effects, for example, on pain-induced antinociception in mice (Ignatowska-Jankowska B. et al., J. Pharmacol. Exp. Ther. 2015, 353, 424) and on psychiatric disorders such as depression in chronic stress models (Zhong P. et al., Neuropsychopharmacology 2014, 39, 1763).

[0007] Furthermore, oligodendrocytes (OLs), myelinating cells in the central nervous system, and their precursors (OPCs) express cannabinoid receptor 2 (CB2) on their membranes. 2-AG is an endogenous ligand for both CB1 and CB2 receptors. It has been reported that both cannabinoids and pharmacological inhibition of MAGL attenuate the vulnerability of OLs and OPCs to excitotoxic injury and may therefore be neuroprotective (Bernal-Chico, A., et al., Glia 2015, 63, 163). Additionally, pharmacological inhibition of MAGL increases the number of myelinating OLs in the mouse brain, suggesting that MAGL inhibition may promote OPC differentiation into myelinating OLs in vivo (Alpar, A., et al., Nature Communications 2014, 5, 4421). Inhibition of MAGL has also been shown to promote remyelination and functional recovery in a mouse model of progressive multiple sclerosis (Feliu A et al., Journal of Neuroscience 2017, 37(35), 8385.).

[0008] Furthermore, metabolism, especially lipid metabolism, has recently been given great importance in cancer research. Researchers believe that de novo fatty acid synthesis plays an important role in tumor development. Many studies have shown that endocannabinoids have antitumor effects, including antiproliferative, apoptosis-inducing, and anti-metastatic effects. MAGL, as a key degradative enzyme for both lipid metabolism and the endocannabinoid system, further contributes to various aspects of tumorigenesis, including glioblastoma, as part of gene expression profiles (Qin, H., et al., Cell Biochem. Biophys. 2014, 70, 33; Nomura DK et al., Cell 2009, 140(1), 49-61; Nomura DK et al., Chem. Biol. 2011, 18(7), 846-856; Jinlong Yin et al., Nature Communications 2020, 11, 2978).

[0009] The endocannabinoid system is also involved in many gastrointestinal physiological and physiopathological functions (Marquez, Suarez et al. 2009). All of these effects are primarily driven through cannabinoid receptors (CB1 and CB2). CB1 receptors are present throughout the gastrointestinal tract in animals and healthy humans, particularly in the enteric nervous system (ENS) and epithelial lining, as well as in smooth muscle cells of blood vessels in the colon wall (Wright, Rooney et al. 2005, Duncan, Davison et al. 2005). CB1 activation provides antiemetic, antimotility, and anti-inflammatory effects and helps regulate pain (Perisetti, Rimu et al. 2020). CB2 receptors are expressed in immune cells such as plasma cells and macrophages, the lamina propria of the gastrointestinal tract (Wright, Rooney et al. 2005), and the epithelium of human colonic tissue, primarily associated with inflammatory bowel disease (IBD). CB2 activation exerts anti-inflammatory effects by reducing pro-inflammatory cytokines. MAGL expression is increased in colonic tissues of UC patients (Marquez, Suarez, et al. 2009), and 2-AG levels are increased in the plasma of IBD patients (Grill, Hogenauer, et al. 2019). Several animal studies have demonstrated the potential of MAGL inhibitors for the symptomatic treatment of IBD. MAGL inhibition prevents TNBS-induced murine colitis and reduces local and circulating inflammatory markers via CB1 / CB2 MoA (Marquez, Suarez, et al. 2009). Furthermore, MAGL inhibition improves intestinal wall integrity and intestinal permeability via CB1-driven MoA (Wang, Zhang, et al. 2020).

[0010] In conclusion, inhibiting the action and / or activation of MAGL is a promising new therapeutic strategy for treating or preventing neuroinflammation, neurodegenerative diseases, pain, cancer, psychiatric disorders, inflammatory bowel disease, abdominal pain, and abdominal pain associated with irritable bowel syndrome. Furthermore, inhibiting the action and / or activation of MAGL is a promising new therapeutic strategy for neuroprotection and myelin regeneration. Thus, there is a high unmet medical need for new MAGL inhibitors. Summary of the Invention

[0011] In a first aspect, the present invention provides a compound of formula (I) [ka] (Wherein A and R 1 ~R 4 is as defined herein.

[0012] In a further aspect, the present invention provides a method for preparing a compound of formula (I) described herein, or a pharmaceutically acceptable salt thereof, the method being described in any one of Schemes 1 to 40.

[0013] In a further aspect, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, when prepared according to the processes described herein.

[0014] In a further aspect, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, for use as a therapeutically active substance.

[0015] In a further aspect, the present invention provides a pharmaceutical composition comprising a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.

[0016] In a further aspect, the present invention provides a compound of formula (I), as described herein, or a pharmaceutically acceptable salt thereof, for use in a method of inhibiting monoacylglycerol lipase in a mammal.

[0017] In a further aspect, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of neuroinflammation, neurodegenerative diseases, pain, cancer, psychiatric disorders and / or inflammatory bowel disease in a mammal.

[0018] In a further aspect, the present invention provides a compound of formula (I) as described herein or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, hepatocellular carcinoma, colon carcinogenesis, ovarian cancer, neuropathic pain, chemotherapy-induced neuropathy, acute pain, chronic pain, spasticity associated with pain, abdominal pain, abdominal pain associated with irritable bowel syndrome, and / or visceral pain in a mammal. DETAILED DESCRIPTION OF THE INVENTION

[0019] definition It should be understood that any feature, integer, characteristic, compound, chemical moiety, or group described in connection with a particular aspect, embodiment, or example of the invention is applicable to any other aspect, embodiment, or example described herein, except where inconsistent therewith. All features disclosed herein (including any accompanying claims, abstract, and drawings), and / or all steps of any method or process so disclosed, may be combined in any combination, except combinations in which at least some of such features and / or steps are mutually exclusive. The invention is not limited to the details of any of the foregoing embodiments. The invention extends to any novel or any novel combination of features disclosed herein (including any accompanying claims, abstract, and drawings), or any novel or any novel combination of steps of any method or process so disclosed.

[0020] The term "alkyl" refers to a monovalent or polyvalent, e.g., monovalent or divalent, straight-chain or branched saturated hydrocarbon group having 1 to 12 carbon atoms. In some preferred embodiments, an alkyl group has 1 to 6 carbon atoms ("C 1-6In other embodiments, the alkyl group contains 1 to 3 carbon atoms, e.g., 1, 2, 3, 4, 5, or 6 carbon atoms. In other embodiments, the alkyl group contains 1 to 3 carbon atoms, e.g., 1, 2, or 3 carbon atoms. Some non-limiting examples of alkyl include methyl, ethyl, propyl, 2-propyl (isopropyl), n-butyl, iso-butyl, sec-butyl, tert-butyl, and 2,2-dimethylpropyl. Particularly preferred, but non-limiting, examples of alkyl are methyl, tert-butyl, and 2,2-dimethylpropyl.

[0021] The term "alkoxy" refers to an alkyl group, as defined previously, attached to the parent molecular moiety through an oxygen atom. An alkoxy group contains 1 to 12 carbon atoms, unless otherwise specified. In some preferred embodiments, an alkoxy group contains 1 to 6 carbon atoms ("C 1-6 In other embodiments, alkoxy groups contain 1 to 4 carbon atoms. In still other embodiments, alkoxy groups contain 1 to 3 carbon atoms. Some non-limiting examples of alkoxy groups include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, and tert-butoxy. A particularly preferred, but non-limiting example of alkoxy is methoxy.

[0022] The term "halogen" or "halo" refers to fluoro (F), chloro (Cl), bromo (Br), or iodo (I). Preferably, the term "halogen" or "halo" refers to fluoro (F), chloro (Cl), or bromo (Br). Particularly preferred, but non-limiting, examples of "halogen" or "halo" are fluoro (F) and chloro (Cl).

[0023] As used herein, the term "cycloalkyl" refers to a saturated or partially unsaturated, monocyclic or bicyclic hydrocarbon group of 3 to 10 ring carbon atoms ("C 3-10In some preferred embodiments, the cycloalkyl group is a saturated monocyclic hydrocarbon group of 3 to 8 ring carbon atoms. "Bicyclic cycloalkyl" refers to a cycloalkyl moiety consisting of two saturated carbocyclic rings having two common carbon atoms, i.e., the bridge separating the two rings is either a single bond or a chain of one or two ring atoms, and a spirocyclic moiety, i.e., the two rings are joined through one common ring atom. Preferably, the cycloalkyl group is a saturated monocyclic hydrocarbon group of 3 to 6 ring carbon atoms, e.g., 3, 4, 5, or 6 carbon atoms. Some non-limiting examples of cycloalkyl include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, 1-bicyclo[1.1.1]pentanyl, norbornanyl, and 1-bicyclo[2.2.2]octanyl. A particularly preferred, but non-limiting, example of cycloalkyl is cyclopropyl.

[0024] The term "aryl" refers to a group having a total of 6 to 14 ring members ("C6-C 14 -aryl"), preferably a monocyclic, bicyclic, or tricyclic carbocyclic ring system having 6 to 12 ring members, more preferably 6 to 10 ring members, in which at least one ring of the system is aromatic. Some non-limiting examples of aryl include phenyl and 9H-fluorenyl (e.g., 9H-fluoren-9-yl). A particularly preferred, but non-limiting example of aryl is phenyl.

[0025] The term "heteroaryl" refers to a monocyclic or polyvalent monocyclic, bicyclic, or tricyclic, preferably monocyclic or bicyclic, ring system having a total of 5 to 14 ring members, preferably 5 to 12 ring members, more preferably 5 to 10 ring members, and especially 5 to 9 ring members, 5 to 8 ring members, or 5 to 6 ring members, in which at least one ring in the system is aromatic and at least one ring in the system contains one or more heteroatoms. Preferably, "heteroaryl" refers to a 5- to 10-membered heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from O, S, and N. Most preferably, "heteroaryl" refers to a 5- to 10-membered heteroaryl, 5- to 9-membered heteroaryl, 5- to 8-membered heteroaryl, or 5- to 6-membered heteroaryl containing 1 to 2 heteroatoms independently selected from O, S, and N.Some non-limiting examples of heteroaryls include spiro[cyclopropane-1,3′-indoline] (e.g., spiro[cyclopropane-1,3′-indoline]-1′-yl), 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrazin-2-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-6-yl, indol-1-yl, 1H-indol-2-yl, 1H-indol-3-yl, 1H-indol-4-yl, 1H-indol-5-yl, 1H-indol-6-yl, 1H-indol-8-yl, 1H-indol-9-yl, 1H-indol-10-yl, 1H-indol-11-yl, 1H-indol-12-yl, 1H-indol-13-yl, 1H-indol-14-yl, 1H-indol-15-yl, 1H-indol-16-yl, 1H-indol-17-yl, 1H-indol-18-yl, 1H-indol-19-yl, 1H-indol-19-yl, 1H-indol-20-yl, 1H-indol-21-yl, 1H-indol-22-yl, 1H-indol-23-yl, 1H-indol-24-yl, 1H-indol-25-yl, 1H-indol-26-yl, 1H-indol-27-yl, 1H-indol-28-yl, 1H-indol-29-yl, 1H-indol-21-yl, 1H-indol-21-yl, 1H-indol-21-yl, 1H-indol-22-yl, 1H-indol-23-yl indol-6-yl, 1H-indol-7-yl, 1,2-benzoxazol-3-yl, 1,2-benzoxazol-4-yl, 1,2-benzoxazol-5-yl, 1,2-benzoxazol-6-yl, 1,2-benzoxazol-7-yl, 1H-indazol-3-yl, 1H-indazol-4-yl, 1H-indazol-5-yl, 1H-indazol-6-yl, 1H-indazol-7-yl, pyrazol-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, 1H-Pyrazol-5-yl, pyrazolo[1,5-a]pyridine, 2H-pyrazolo[4,3-b]pyridine, [1,2,4]triazolo[1,5-a]pyridine, 1H-pyrrolo[2,3-b]pyridine, imidazol-1-yl, 1H-imidazol-2-yl, 1H-imidazol-4-yl, 1H-imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, thiazol-2-yl, thiazol- 4-yl, thiazol-5-yl, pyridazin-3-yl, pyridazin-4-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-1-yl, 4H-1,2,4-triazol-3-yl, triazol-2-yl, 2H-triazolyl, 4,5,6,7-tetrahydroindazol-2-yl, 6,7-dihydro-4H-pyrano[4,3-c]pyrazol-2-yl, thiazolyl, benzofurazan-4-yl, tetrazolyl, isoxazolyl, pyrrolyl and morpholinyl.Particularly preferred, but non-limiting examples of heteroaryl are pyridyl, pyrazinyl, pyrimidinyl, pyrazolyl, imidazolyl, oxazolyl, oxadiazolyl and triazolyl.

[0026] The term "heterocyclyl" refers to a saturated or partially unsaturated monocyclic or bicyclic ring system of 3 to 14 ring atoms, preferably 3 to 10 ring atoms, more preferably 3 to 8 ring atoms, more preferably 3 to 6 ring atoms, especially 3, 4, 5, or 6 ring atoms, in which 1, 2, or 3 of the ring atoms are heteroatoms selected from N, O, and S, and the remaining ring atoms are carbon. Preferably, 1 to 2 of the ring atoms are selected from N and O, and the remaining ring atoms are carbon. "Bicyclic heterocyclyl" refers to heterocyclic moieties consisting of two rings that share two ring atoms (i.e., the bridge separating the two rings is either a single bond or a chain of one or two ring atoms) and spirocyclic moieties (i.e., the two rings are connected through one common ring atom). Some non-limiting examples of heterocyclyl groups include azetidinyl, pyrrolidinyl, oxetanyl, 5-azaspiro[2.5]octan-5-yl, piperidyl, 3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl, 2-azaspiro[3.3]heptan-2-yl, 2,6-diazaspiro[3.3]heptanyl, 2-azaspiro[3.4]octane, 2-azaspiro[3.5]nonan-2-yl, 1,2-dihydropyridinyl, piperidyl, and thietanyl.

[0027] The term "hydroxy" refers to the group --OH.

[0028] The term "cyano" refers to a -CN (nitrile) group.

[0029] The term "carboxy" refers to a -COOH group (ie, a carboxylic acid group).

[0030] The term "alkoxycarbonyl" refers to a -C(O)-O-C1-C6-alkyl group (ie, a carboxylic acid ester group).

[0031] The term "oxo" refers to a double-bonded oxygen (=O).

[0032] The term "carbamoyl" refers to the group H2N-C(O)-.

[0033] The term "haloalkyl" refers to an alkyl group in which at least one hydrogen atom of the alkyl group is replaced by a halogen atom, preferably fluoro. Preferably, "haloalkyl" refers to an alkyl group in which one, two, or three hydrogen atoms of the alkyl group are replaced by a halogen atom, most preferably fluoro. Particularly preferred, but non-limiting, examples of haloalkyl are trifluoromethyl, difluoromethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, and 2,2,2-trifluoroethyl.

[0034] The term "hydroxyalkyl" refers to an alkyl group in which at least one hydrogen atom of the alkyl group is replaced by a hydroxy group. Preferably, "haloalkyl" refers to an alkyl group in which one, two, or three hydrogen atoms, particularly one hydrogen atom, of the alkyl group is replaced by a hydroxy group. A particularly preferred, but non-limiting example of a hydroxyalkyl is hydroxymethyl.

[0035] The term "carboxyalkyl" refers to an alkyl group in which at least one of the alkyl group's hydrogen atoms has been replaced by a carboxy group. Preferably, "carboxyalkyl" refers to an alkyl group in which one, two, or three, and particularly one, hydrogen atom of the alkyl group has been replaced by a carboxy group. A particularly preferred, but non-limiting, example of a carboxyalkyl is 1-carboxy-1-methyl-ethyl.

[0036] The term "haloalkoxy" refers to an alkoxy group in which at least one hydrogen atom of the alkoxy group is replaced by a halogen atom, preferably fluoro. Preferably, "haloalkoxy" refers to an alkoxy group in which one, two, or three hydrogen atoms of the alkoxy group are replaced by a halogen atom, most preferably fluoro. Particularly preferred, but non-limiting, examples of haloalkoxy are trifluoromethoxy, difluoromethoxy, 2,2,2-trifluoro-1,1-dimethyl-ethoxy, (1,1,1-trifluoropropan-2-yl)oxy, and 2,2,2-trifluoroethoxy.

[0037] The term "pharmaceutically acceptable salt" refers to a salt that retains the biological effectiveness and properties of the free base or free acid, and is not biologically or otherwise undesirable. Salts are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, etc., especially hydrochloric acid, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, N-acetylcysteine, etc. Additionally, these salts can be prepared by adding an inorganic or organic base to the free acid. Salts derived from inorganic bases include, but are not limited to, sodium, potassium, lithium, ammonium, calcium, and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, lysine, arginine, N-ethylpiperidine, piperidine, polyimine resins, and the like.

[0038] The compounds of formula (I) may contain several asymmetric centers and may exist as optically pure enantiomers, mixtures of enantiomers, e.g. racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereomeric racemates or mixtures of diastereomeric racemates.

[0039] According to the Cahn-Ingold-Prelog rules, the asymmetric carbon atom may be of the "R" or "S" configuration.

[0040] The abbreviation "MAGL" refers to the enzyme monoacylglycerol lipase. The terms "MAGL" and "monoacylglycerol lipase" are used interchangeably herein.

[0041] The term "treatment," as used herein, includes: (1) suppressing the symptom, disorder, or condition (e.g., in the case of maintenance treatment, arresting, reducing, or delaying the onset or recurrence of at least one clinical symptom or subclinical disease thereof), and / or (2) alleviating the condition (i.e., causing regression of the symptom, disorder, or condition, or at least one of its clinical symptoms or subclinical symptoms). The benefit to the patient to be treated is either statistically significant or at least discernible to the patient or physician. However, it will be understood that when a patient is administered a medication to treat a disease, the outcome need not necessarily be effective treatment.

[0042] The term "prophylaxis" as used herein includes preventing or delaying the appearance of clinical symptoms of a condition, disorder or condition that develops in a mammal, particularly in a human suffering from or susceptible to the condition, disorder or condition, but who has not yet experienced or exhibited clinical symptoms or asymptomatic symptoms of the condition, disorder or condition.

[0043] The term "neuroinflammation," as used herein, refers to acute and chronic inflammation of nervous tissue, which is a major tissue component of two parts of the nervous system: the brain and spinal cord of the central nervous system (CNS), and the branching peripheral nerves of the peripheral nervous system (PNS). Chronic neuroinflammation is associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Acute neuroinflammation usually occurs immediately after central nervous system injury, for example, as a result of traumatic brain injury (TBI).

[0044] The term "traumatic brain injury" (also known as "TBI," "intracranial injury") relates to damage to the brain resulting from an external mechanical force such as rapid acceleration or deceleration, impact, blast, or penetration by a projectile.

[0045] The term "neurodegenerative disease" refers to diseases associated with the progressive loss of neuronal structure or function, including neuronal death. Examples of neurodegenerative diseases include, but are not limited to, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

[0046] The term "mental disorder" (also called mental illness or mental disorder) relates to a behavioral or mental pattern that can cause distress or impaired functioning in life. Such characteristics may occur as persistent, relapsing, and remitting, or as a single episode. Examples of mental disorders include, but are not limited to, anxiety and depression.

[0047] The term "pain" relates to an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Examples of pain include, but are not limited to, nociceptive pain, chronic pain (including idiopathic pain), neuropathic pain including chemotherapy-induced neuropathy, phantom limb pain, and psychogenic pain. A particular example of pain is neuropathic pain, which is caused by injury or disease affecting any part of the nervous system involved in bodily sensations (i.e., the somatosensory system). In one embodiment, the "pain" is neuropathic pain resulting from amputation or thoracotomy. In one embodiment, the "pain" is chemotherapy-induced neuropathy.

[0048] The term "neurotoxicity" relates to toxicity in the nervous system. It occurs when exposure to natural or man-made toxic substances (neurotoxins) alters the normal activity of the nervous system, causing damage to nervous tissue. Examples of neurotoxicity include, but are not limited to, exposure to substances used in chemotherapy, radiation treatment, drug therapy, drug abuse, and organ transplants, as well as neurotoxicity resulting from exposure to heavy metals, certain foods and food additives, pesticides, industrial and / or cleaning solvents, cosmetics, and some naturally occurring substances.

[0049] The term "cancer" refers to a disease characterized by the presence of a neoplasm or tumor, resulting from the abnormal and uncontrolled growth of cells (such cells are "cancer cells"). As used herein, the term cancer expressly includes, but is not limited to, hepatocellular carcinoma, colon carcinoma, and ovarian cancer.

[0050] The term "mammal," as used herein, includes both humans and non-humans, including, but not limited to, humans, non-human primates, canines, felines, murines, bovines, equines, and porcines. In a particularly preferred embodiment, the term "mammal" refers to humans.

[0051] Compounds of the Invention In a first aspect, the present invention provides a compound of formula (I) [ka] (In the formula, A is, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 is a covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13c CH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -CH2SO2-, -SO2CH2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2 is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CHO-, -OCH2-, -SO2-, -CH2SO2-, and -SO2CH2-; X is NH or O, R 1 is the base [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 3 is selected from hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy and hydroxy, R 4 is hydrogen and the group -C(R 4a R 4b R 4c ) and R 4a is selected from C-C-alkyl and halo-C-C-alkyl, R 4b is selected from hydrogen and hydroxy; R 4C is hydrogen, or R 4a , R 4b and R 4c are each independently selected from hydrogen and halogen; R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 -cycloalkyl or 3- to 14-membered heterocyclyl, and R 4c is selected from hydrogen, hydroxy, amino, and halogen, and C3-C 10 -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R 5is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, amino, C1-C6-alkyl-NH-, (C1-C6-alkyl)2N-, carbamoyl, C1-C6-alkyl-NH-C(O)-, (C1-C6-alkyl)2N-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, groups [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen, halogen, C1-C6-alkyl and carbamoyl, R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkyl-NH-, (C1-C6-alkyl)2N-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 Together, we can [ka] Forming R 10 is selected from hydrogen, halogen, C1-C6-alkyl, halo-C1-C6-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13a , R 13b and R 13c are each independently hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-) or a pharmaceutically acceptable salt thereof.

[0052] In one embodiment, the present invention provides A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10- selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 But covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13c CH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -CH2SO2-, -SO2CH2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2 is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CHO-, -OCH2-, -SO2-, -CH2SO2-, and -SO2CH2-; X is NH or O, R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 3 is selected from hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy and hydroxy, R 4 is hydrogen, and the group -C(R 4a R 4b R 4c ) and R 4ais selected from C-C-alkyl and halo-C-C-alkyl, R 4b is selected from hydrogen and hydroxy; R 4C is hydrogen, or R 4a , R 4b and R 4c are each independently selected from hydrogen and halogen; R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 -cycloalkyl or 3- to 14-membered heterocyclyl, and R 4c is selected from hydrogen, hydroxy, amino, and halogen, and the C3-C 10 -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R 5 is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, amino, C1-C6-alkyl-NH-, (C1-C6-alkyl)2N-, carbamoyl, C1-C6-alkyl-NH-C(O)-, (C1-C6-alkyl)2N-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, groups [ka] and groups [ka] is selected from R 6is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen, halogen, and carbamoyl; R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkyl-NH-, (C1-C6-alkyl)2N-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 But together, [ka] Forming R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13ais hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, R 13c is selected from hydrogen and C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0053] In one embodiment, the present invention provides a compound wherein A is [ka] or a pharmaceutically acceptable salt thereof.

[0054] In a preferred embodiment, the present invention provides a compound wherein A is [ka] or a pharmaceutically acceptable salt thereof.

[0055] In one embodiment, the present invention provides B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 But covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13CCH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2 is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CHO-, -OCH2-, -SO2-, and -CH2SO2-; X is NH or O, R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 5 is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen, halogen, C1-C6-alkyl, and carbamoyl, R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 But together, [ka] Forming R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R12 is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13a is hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, R 13c is selected from hydrogen and C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0056] In one embodiment, the present invention provides B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 But covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13C CH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2 is a covalent bond, -CR 8a R 8bselected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CH2O-, -SO2-, and -CH2SO2-; X is NH or O, R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 5 is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8ais selected from hydrogen, halogen, and carbamoyl; R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 But together, [ka] Forming R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13a is hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, R 13cis selected from hydrogen and C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0057] In a preferred embodiment, the present invention comprises: B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C3-C 10 - selected from cycloalkyl and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CR 8a R 8b -, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 Based on [ka] and R 2 is hydrogen, R 5 is halogen, cyano, halo-C1-C6-alkyl, oxo, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano and halo-C1-C6-alkyl, R 7 is selected from hydrogen and C1-C6-alkyl, R8a is selected from hydrogen and halogen; R 8b is selected from hydrogen and halogen; R 9 is selected from hydrogen, C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen, C1-C6-alkyl and halo-C1-C6-alkyl, R 11 is hydrogen, R 12 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0058] In a particularly preferred embodiment, the present invention comprises: B is selected from phenyl, bicyclo[1.1.1]pentyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-dihydropyridyl, and 1,2-dihydropyrazinyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazolyl, 1,3,4-thiadiazolyl, and pyrazinyl; L 1 is a covalent bond, -CR 8a R 8b -, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 But, [ka] and R 2 is hydrogen, R 5chloro, fluoro, cyano, CF3, 2,2,2-trifluoroethyl, CF3O, oxo, methylsulfonyl, CF3-SO2-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro, cyano and CF3; R 7 is selected from hydrogen and methyl; R 8a is selected from hydrogen and fluoro; R 8b is selected from hydrogen and fluoro; R 9 is selected from hydrogen, methyl, 2,2-dimethylpropyl, CHF2 and CF3; R 10 is selected from hydrogen, methyl and CF3; R 11 is hydrogen, R 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0059] In a particularly preferred embodiment, the present invention comprises: B is selected from phenyl, bicyclo[1.1.1]pentyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, and 1,2-dihydropyridyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazolyl, 1,3,4-thiadiazolyl, and pyrazinyl; L 1is a covalent bond, -CR 8a R 8b -, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 But, [ka] and R 2 is hydrogen, R 5 chloro, fluoro, cyano, CF3, CF3O, oxo, methylsulfonyl, CF3-SO2-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro, cyano and CF3; R 7 is selected from hydrogen and methyl; R 8a is selected from hydrogen and fluoro; R 8b is selected from hydrogen and fluoro; R 9 is selected from hydrogen, methyl, 2,2-dimethylpropyl, CHF2 and CF3; R 10 is selected from hydrogen, methyl and CF3; R 11 is hydrogen, R 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0060] In one embodiment, the present invention provides A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 But covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13C CH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2 is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CHO-, -OCH2-, -SO2-, and -CH2SO2-; X is NH or O, R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R2 is selected from hydrogen and hydroxy; R 3 is hydrogen, R 4 is hydrogen, and the group -C(R 4a R 4b R 4c ) and R 4a is halo-C1-C6-alkyl and R 4b is hydroxy and R 4c is hydrogen, or R 4a , R 4b , and R 4c are each independently a halogen; R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 -cycloalkyl or 3- to 14-membered heterocyclyl, and R 4c is selected from hydrogen, hydroxy, amino, and halogen, and C3-C 10 -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R 5 is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen, halogen, C1-C6-alkyl, and carbamoyl, R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 But together, [ka] Forming R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13a is hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, R 13c is selected from hydrogen and C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0061] In one embodiment, the present invention provides A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 But covalent bond, carbonyl, -CR 8a R 8b -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b CH2-, -CH2CH2-, -CH2NR 13C CH2-, -CH2NHCO-, -O-, -NH-, -SO2NH-, -NHSO2-, -SO2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)-, -C(O)NH-, and [ka] is selected from L 2is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CH2O-, -SO2-, and -CH2SO2-; X is NH or O, R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a is halo-C1-C6-alkyl and R 4b is hydroxy and R 4c is hydrogen, or R 4a , R 4b , and R 4c are each independently a halogen; R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 -cycloalkyl or 3- to 14-membered heterocyclyl, and R 4c is selected from hydrogen, hydroxy, amino, and halogen, and C3-C 10 -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R 5is hydrogen, hydroxy, halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, hydroxy-halo-C1-C6-alkyl, carboxy-C1-C6-alkyl, halo-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-; R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen, halogen, and carbamoyl; R 8b is selected from hydrogen and halogen; R 9 is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkyl-NH-, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C3-C 10-cycloalkyl, cyano, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl; 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted with one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, or R 9 and R 5 But together, [ka] Forming R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from amino, C1-C6-alkyl and halo-C1-C6-alkyl, R 13a is hydrogen, C1-C6-alkyl, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, R 13c is selected from hydrogen and C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0062] In a preferred embodiment, the present invention comprises: A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C3-C 10 - selected from cycloalkyl and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CR 8a R 8b -, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 But, [ka] and R 2 is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently a halogen, or R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is selected from hydrogen, hydroxy, and halogen, and the C3-C 10 -cycloalkyl is optionally substituted with 1 to 2 halogen substituents; R 5 is halogen, cyano, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, oxo, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano and halo-C1-C6-alkyl, R 7 is selected from hydrogen and C1-C6-alkyl, R 8a is selected from hydrogen and halogen; R 8b is selected from hydrogen and halogen; R 9 is selected from hydrogen, C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen, C1-C6-alkyl and halo-C1-C6-alkyl, R 11 is hydrogen, R 12 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0063] In a particularly preferred embodiment, the present invention comprises: A, [ka] is selected from B is selected from phenyl, bicyclo[1.1.1]pentanyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-dihydropyridyl, and 1,2-dihydropyrazinyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazole, pyrazinyl, and 1,3,4-thiadiazolyl; L 1 is a covalent bond, -CR 8a R 8b-, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 But, [ka] and R 2 is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently fluoro, or R 4a and R 4b together with the carbon atom to which they are attached to form a cyclopropyl, and R 4c is selected from hydrogen, hydroxy, and fluoro, wherein the cyclopropyl is optionally substituted with 1 to 2 fluoro substituents; R 5 chloro, fluoro, cyano, CF3, 2,2,2-trifluoroethyl, CF3O, methylsulfonyl, CF3-SO2-, oxo, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro, cyano and CF3; R 7 is selected from hydrogen and methyl; R 8ais selected from hydrogen and fluoro; R 8b is selected from hydrogen and fluoro; R 9 is selected from hydrogen, methyl, 2,2-dimethylpropyl, CHF2 and CF3; R 10 is selected from hydrogen, methyl and CF3; R 11 is hydrogen, R 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0064] In a particularly preferred embodiment, the present invention comprises: A, [ka] is selected from B is selected from phenyl, bicyclo[1.1.1]pentanyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, and 1,2-dihydropyridyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazole, pyrazinyl, and 1,3,4-thiadiazolyl; L 1 is a covalent bond, -CR 8a R 8b -, and -CHO-; L 2 is selected from a covalent bond, —NH—, and —CHNH—; X is NH or O, R 1 But, [ka] and R 2is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently fluoro, or R 4a and R 4b together with the carbon atom to which they are attached to form a cyclopropyl, and R 4c is selected from hydrogen, hydroxy, and fluoro, wherein the cyclopropyl is optionally substituted with 1 to 2 fluoro substituents; R 5 Chloro, fluoro, CF3, CF3O, methylsulfonyl, CF3-SO2-, oxo, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro, cyano and CF3; R 7 is selected from hydrogen and methyl; R 8a is selected from hydrogen and fluoro; R 8b is selected from hydrogen and fluoro; R 9 is selected from methyl, 2,2-dimethylpropyl, CHF2 and CF3; R 10 is selected from hydrogen, methyl and CF3; R 11 is hydrogen, R 12is CF3, or a pharmaceutically acceptable salt thereof.

[0065] In a particularly preferred embodiment, the present invention comprises: A, [ka] and B is a 5- to 6-membered heteroaryl; L 1 Ga-CR 8a R 8b - and R 1 But, [ka] and R 2 is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a and R 4b together with the carbon atom to which they are attached to form a cyclopropyl, and R 4c is hydrogen, R 5 is halo-C1-C6-alkyl, R 6 is hydrogen, R 7 is hydrogen, R 8a is hydrogen, R 8b is hydrogen, or a pharmaceutically acceptable salt thereof.

[0066] In one embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-9 membered heteroaryl.

[0067] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-6 membered heteroaryl.

[0068] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is a 5-membered heteroaryl.

[0069] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 6-membered heteroaryl.

[0070] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is selected from phenyl, bicyclo[1.1.1]pentyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-dihydropyridyl and 1,2-dihydropyrazinyl.

[0071] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is selected from pyrimidinyl, pyrazinyl, and 2H-triazolyl.

[0072] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is phenyl.

[0073] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is bicyclo[1.1.1]pentyl.

[0074] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is oxazolyl.

[0075] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyrazinyl.

[0076] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyridazinyl.

[0077] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl.

[0078] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is imidazolyl.

[0079] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1H-1,2,4-triazolyl.

[0080] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 2H-triazolyl.

[0081] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is isoxazolyl.

[0082] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,2,4-oxadiazolyl.

[0083] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,3,4-oxadiazolyl.

[0084] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,2-dihydropyrazinyl.

[0085] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is selected from pyridyl, 1,2-dihydropyridyl, pyrimidinyl, 1,2,4-thiadiazolyl, 1,2,3-oxadiazolyl, triazol-2-yl, and pyrazolyl.

[0086] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,2,3-oxadiazolyl.

[0087] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,2-dihydropyridyl.

[0088] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is triazol-2-yl.

[0089] In a preferred embodiment, the present invention comprises: C is C3-C 10 -cycloalkyl, R 9 is halo-C1-C6-alkyl, R 10 is hydrogen, R 11 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0090] In a particularly preferred embodiment, the present invention comprises: C is cyclopropyl; R 9 is CF3, R 10 is hydrogen, R 11 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0091] In one embodiment, the present invention provides a method for producing a compound comprising: 1 is a covalent bond, or a pharmaceutically acceptable salt thereof.

[0092] In one embodiment, the present invention provides L 1 Ga-CR 8a R 8b - and R 8a is selected from hydrogen and halogen; R 8b is selected from hydrogen and halogen, or a pharmaceutically acceptable salt thereof.

[0093] In a preferred embodiment, the present invention comprises: L 1 Ga-CR 8a R 8b - and R 8a is selected from hydrogen and fluoro; R 8b is selected from hydrogen and fluoro, or a pharmaceutically acceptable salt thereof.

[0094] In a particularly preferred embodiment, the present invention provides 1 is —CH 2 —, or a pharmaceutically acceptable salt thereof.

[0095] In one embodiment, the present invention provides a method for producing a compound comprising: 1is —CH2O—, or a pharmaceutically acceptable salt thereof.

[0096] In a particularly preferred embodiment, the present invention comprises: L 1 is -CH2-, Provided herein is a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-6 membered heteroaryl.

[0097] In a particularly preferred embodiment, the present invention comprises: L 1 is -CH2-, Provided herein are compounds of formula (I) or pharmaceutically acceptable salts thereof, as described herein, wherein B is selected from pyrimidinyl, pyrazinyl and 2H-triazolyl.

[0098] In one embodiment, the present invention provides L 2 is a covalent bond, -CR 8a R 8b selected from -, -NH-, -N(C1-C6-alkyl)-, -O-, -CH2NH-, -NHCH2-, -CHO-, -OCH2-, -SO2-, and -CH2SO2-; R 8a is selected from hydrogen, halogen, C1-C6-alkyl, and carbamoyl, R 8b Provided herein are compounds of formula (I) as described herein, or pharmaceutically acceptable salts thereof, wherein is selected from hydrogen and halogen.

[0099] In a preferred embodiment, the present invention provides L 2 is a covalent bond, or a pharmaceutically acceptable salt thereof.

[0100] In a preferred embodiment, the present invention provides R 3 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0101] In one embodiment, the present invention provides R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently a halogen, or R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is selected from hydrogen, hydroxy, and halogen, and C3-C 10 The present invention provides compounds of formula (I) as described herein, or pharmaceutically acceptable salts thereof, wherein -cycloalkyl is optionally substituted with 1 to 2 halogen substituents.

[0102] In a preferred embodiment, the present invention comprises: R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently a halogen, or R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is selected from hydrogen, hydroxy, and halogen, and C3-C 10 The present invention provides compounds of formula (I) as described herein, or pharmaceutically acceptable salts thereof, wherein -cycloalkyl is optionally substituted with 1 to 2 halogen substituents.

[0103] In a particularly preferred embodiment, the present invention comprises: R 4 is the group -C(R 4a R 4b R 4c ) and R 4a , R 4b , and R 4c are each independently fluoro, or R 4a and R 4b together with the carbon atom to which they are attached to form cyclopropyl or cyclobutyl, and R 4c is selected from hydrogen, hydroxy, and fluoro, and cyclopropyl is substituted with 1 to 2 fluoro substituents, or a pharmaceutically acceptable salt thereof.

[0104] In one embodiment, the present invention provides a compound comprising R 4 halo-C1-C6-alkyl and C3-C 10 -cycloalkyl, wherein the C3-C 10 -cycloalkyl is optionally substituted with 1 to 3 substituents selected from halogen and hydroxy; or a pharmaceutically acceptable salt thereof.

[0105] In one embodiment, the present invention provides a compound comprising R 4 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0106] In a preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein R 4 is CF3.

[0107] In one embodiment, the present invention provides a compound comprising R 4 C3-C 10 -cycloalkyl, and the C3-C 10 -cycloalkyl is optionally substituted with 1 to 3 substituents selected from halogen and hydroxy; or a pharmaceutically acceptable salt thereof.

[0108] In a preferred embodiment, the present invention provides R4 is cyclopropyl or cyclobutyl, and said cyclopropyl or cyclobutyl is optionally substituted with 1 to 3 substituents selected from halogen and hydroxy, or a pharmaceutically acceptable salt thereof.

[0109] In a particularly preferred embodiment, the present invention provides 4 is selected from CF3, cyclopropyl, 1-fluorocyclopropyl, 1-hydroxycyclopropyl, and 3,3-difluorocyclobutyl, or a pharmaceutically acceptable salt thereof.

[0110] In a particularly preferred embodiment, the present invention provides 4 but [ka] or a pharmaceutically acceptable salt thereof.

[0111] In a preferred embodiment, the present invention provides R 5 is halogen, cyano, halo-C1-C6-alkyl, oxo, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, [ka] and groups [ka] or a pharmaceutically acceptable salt thereof.

[0112] In a preferred embodiment, the present invention provides R 5 halo-C1-C6-alkyl, [ka] and groups [ka] or a pharmaceutically acceptable salt thereof.

[0113] In a preferred embodiment, the present invention provides R 5 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0114] In a preferred embodiment, the present invention provides R 5 Based on [ka] or a pharmaceutically acceptable salt thereof.

[0115] In a preferred embodiment, the present invention provides R 5 Based on [ka] or a pharmaceutically acceptable salt thereof.

[0116] In a particularly preferred embodiment, the present invention provides 5 chloro, fluoro, cyano, CF3, 2,2,2-trifluoroethyl, CF3O, oxo, methylsulfonyl, CF3-SO2-, [ka] and groups [ka] or a pharmaceutically acceptable salt thereof.

[0117] In a particularly preferred embodiment, the present invention provides 5 is CF3, or a pharmaceutically acceptable salt thereof.

[0118] In a preferred embodiment, the present invention provides R 6 is selected from hydrogen and oxo, or a pharmaceutically acceptable salt thereof.

[0119] In a particularly preferred embodiment, the present invention provides 6 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0120] In a particularly preferred embodiment, the present invention provides 6 is oxo, or a pharmaceutically acceptable salt thereof.

[0121] In a particularly preferred embodiment, the present invention provides 7 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0122] In a particularly preferred embodiment, the present invention provides 6 and R 7 and R are each hydrogen, or a pharmaceutically acceptable salt thereof.

[0123] In a particularly preferred embodiment, the present invention provides a [ka] but [ka] or a pharmaceutically acceptable salt thereof.

[0124] In one embodiment, the present invention provides A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CHR 8 -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13b selected from CH2-, -CH2CH2-, -CH2NHCH2-, -CH2NHCO-, -O-, -NH-, -SON2NH-, -NHSO2-, -SON2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)- and -C(O)NH-; L 2 is selected from a covalent bond, —CH—, —NH—, —N(C1-C6-alkyl)-, —O—, —CH2NH—, —NHCH2—, —CHO—, and SO2—; R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 3is selected from hydrogen, halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, and hydroxy; R 4 is the group -C(R 4a R 4b R 4c ) and R 4a is halo-C1-C6-alkyl and R 4b is hydroxy and R 4c is hydrogen, or R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is hydrogen or hydroxy, R 5 is hydrogen, hydroxy, halogen, C1-C6-alkyl, C1-C6-alkoxy, carbonyl-C1-C6-alkyl, carboxy-C1-C6-alkyl, carbonyl-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-SO2-, carbonyl-C1-C6-alkyl-SO2-, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-, R 7 is selected from hydrogen and C1-C6-alkyl, R 8 is selected from hydrogen and carbamoyl; R 9 is hydrogen, halogen, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl, 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted by one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 13a But hydrogen, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, or a pharmaceutically acceptable salt thereof.

[0125] In one embodiment, the present invention provides a compound wherein A is [ka] or a pharmaceutically acceptable salt thereof.

[0126] In a preferred embodiment, the present invention provides a compound wherein A is [ka] or a pharmaceutically acceptable salt thereof.

[0127] In a particularly preferred embodiment, the present invention provides a method for producing a compound in which A is [ka] or a pharmaceutically acceptable salt thereof.

[0128] In a particularly preferred embodiment, the present invention provides a method for producing a compound in which A is [ka] or a pharmaceutically acceptable salt thereof.

[0129] In a particularly preferred embodiment, the present invention provides a method for producing a compound in which A is [ka] or a pharmaceutically acceptable salt thereof.

[0130] In one embodiment, the present invention provides a method for treating a cancer comprising administering to a patient a cancer treatment comprising administering to a patient a cancer 14 -Aryl, C3-C 10 -cycloalkyl, and 5- to 14-membered heteroaryl, or a pharmaceutically acceptable salt thereof.

[0131] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-14 membered heteroaryl.

[0132] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-10 membered heteroaryl.

[0133] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 5-6 membered heteroaryl.

[0134] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is selected from phenyl, bicyclo[1.1.1]pentane, pyridyl, oxazolyl, pyrimidine, pyrazine, pyridazine, 1,2,4-thiadiazole, pyrazolyl, imidazolyl, and 1H-1,2,4-triazole.

[0135] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is phenyl.

[0136] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is bicyclo[1.1.1]pentane.

[0137] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyridyl.

[0138] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is oxazolyl.

[0139] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyrimidine.

[0140] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyrazine.

[0141] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyridazine.

[0142] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1,2,4-thiadiazole.

[0143] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl.

[0144] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is imidazolyl.

[0145] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein B is 1H-1,2,4-triazole.

[0146] In one embodiment, the present invention provides a method for treating a cancer cell comprising administering to a patient a cancer treatment agent in which C is C3 10 -cycloalkyl and 5- to 14-membered heteroaryl, or a pharmaceutically acceptable salt thereof.

[0147] In a preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein C is selected from cyclopropyl, pyrazolyl, and 1,3,4-oxadiazole.

[0148] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein C is cyclopropyl.

[0149] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein C is pyrazolyl.

[0150] In a particularly preferred embodiment, the present invention provides compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein C is 1,3,4-oxadiazole.

[0151] In a preferred embodiment, the present invention comprises: L 1 is a covalent bond, -CHR 8 -, -CH2O-, and -SO2-; R 8 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0152] In a particularly preferred embodiment, the present invention provides 1 is a covalent bond, or a pharmaceutically acceptable salt thereof.

[0153] In a particularly preferred embodiment, the present invention provides 1 is —CH 2 —, or a pharmaceutically acceptable salt thereof.

[0154] In a particularly preferred embodiment, the present invention provides 1 is —CH2O—, or a pharmaceutically acceptable salt thereof.

[0155] In a particularly preferred embodiment, the present invention provides 1 is —SO 2 —, or a pharmaceutically acceptable salt thereof.

[0156] In a preferred embodiment, the present invention comprises: B is a 5- to 6-membered heteroaryl; L 1

[0013] Provided herein are compounds of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein is -CH2-.

[0157] In a preferred embodiment, the present invention provides L 2 is selected from a covalent bond and —CH 2 NH—, or a pharmaceutically acceptable salt thereof.

[0158] In a preferred embodiment, the present invention provides R 1 Based on [ka] or a pharmaceutically acceptable salt thereof.

[0159] In a preferred embodiment, the present invention provides R 2 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0160] In one embodiment, the present invention provides a compound comprising R 5 is halogen, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, [ka] and groups [ka] or a pharmaceutically acceptable salt thereof.

[0161] In a preferred embodiment, the present invention provides R 5 Chloro, fluoro, CF3, CF3O, methylsulfonyl, CF3-SO2-, groups [ka] and groups [ka] or a pharmaceutically acceptable salt thereof.

[0162] In a preferred embodiment, the present invention provides R 5 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0163] In a particularly preferred embodiment, the present invention provides 5 is CF3, or a pharmaceutically acceptable salt thereof.

[0164] In a preferred embodiment, the present invention comprises: B is a 5- to 6-membered heteroaryl; L 1 is -CH2-, R 5 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0165] In a preferred embodiment, the present invention provides R 6 is selected from hydrogen, halogen and cyano, or a pharmaceutically acceptable salt thereof.

[0166] In a particularly preferred embodiment, the present invention provides 6 is selected from hydrogen, fluoro, and cyano, or a pharmaceutically acceptable salt thereof.

[0167] In a particularly preferred embodiment, the present invention provides 6 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0168] In a particularly preferred embodiment, the present invention comprises: B is a 5- to 6-membered heteroaryl; L1 is -CH2-, R 5 is halo-C1-C6-alkyl, R 6 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0169] In a preferred embodiment, the present invention provides R 7 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0170] In a particularly preferred embodiment, the present invention comprises: B is a 5- to 6-membered heteroaryl; L 1 is -CH2-, R 5 is halo-C1-C6-alkyl, R 6 is hydrogen, R 7 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0171] In a preferred embodiment, the present invention provides R 8 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0172] In a preferred embodiment, the present invention provides R 9 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0173] In a particularly preferred embodiment, the present invention provides 9 is selected from methyl, 2,2-dimethylpropyl, and CF3, or a pharmaceutically acceptable salt thereof.

[0174] In a preferred embodiment, the present invention provides R 10is selected from hydrogen and halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0175] In a particularly preferred embodiment, the present invention provides 10 is selected from hydrogen and CF3, or a pharmaceutically acceptable salt thereof.

[0176] In a preferred embodiment, the present invention provides R 11 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0177] In a preferred embodiment, the present invention comprises: C is C3-C 10 - selected from cycloalkyl and 5- to 14-membered heteroaryl; L 2 is selected from a covalent bond and —CHNH—; R 9 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen and halo-C1-C6-alkyl, R 11 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0178] In a particularly preferred embodiment, the present invention comprises: C is selected from cyclopropyl, pyrazolyl, and 1,3,4-oxadiazole; L 2 is selected from a covalent bond and —CHNH—; R 9 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen and halo-C1-C6-alkyl, R 11is hydrogen, or a pharmaceutically acceptable salt thereof.

[0179] In a preferred embodiment, the present invention provides R 12 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0180] In a particularly preferred embodiment, the present invention provides 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0181] In a preferred embodiment, the present invention comprises: B is C6-C 14 -Aryl, C3-C 10 -cycloalkyl, and 5- to 14-membered heteroaryl; C is C3-C 10 - selected from cycloalkyl and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CHR 8 -, -CH2O-, and -SO2-; L 2 is selected from a covalent bond and —CHNH—; R 1 But, [ka] and R 2 is hydrogen, R 5 is halogen, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen and cyano; R 7 is hydrogen, R 8 is hydrogen, R 9 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen and halo-C1-C6-alkyl, R 11 is hydrogen, R 12 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0182] In a particularly preferred embodiment, the present invention comprises: B is selected from phenyl, bicyclo[1.1.1]pentane, pyridyl, oxazolyl, pyrimidine, pyrazine, pyridazine, 1,2,4-thiadiazole, pyrazolyl, imidazolyl, and 1H-1,2,4-triazole; C is selected from cyclopropyl, pyrazolyl, and 1,3,4-oxadiazole; L 1 is a covalent bond, -CR 8 R 9 -, -CH2O-, and -SO2-; L 2 is selected from a covalent bond and —CHNH—; R 1 But, [ka] and R 2 is hydrogen, R 5 Chloro, fluoro, CF3, CF3O, methylsulfonyl, CF3-SO2-, groups [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro and cyano; R 7 is hydrogen, R 8 is hydrogen, R 9 is selected from methyl, 2,2-dimethylpropyl, and CF3; R 10 is selected from hydrogen and CF3; R 11 is hydrogen, R 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0183] In a preferred embodiment, the present invention provides R 3 is hydrogen, or a pharmaceutically acceptable salt thereof.

[0184] In a preferred embodiment, the present invention comprises: R 4 is the group -C(R 4a R 4b R 4c ) and R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is hydrogen or hydroxy, or a pharmaceutically acceptable salt thereof.

[0185] In a particularly preferred embodiment, the present invention comprises: R 4is the group -C(R 4a R 4b R 4c ) and R 4a and R 4b together with the carbon atom to which they are attached form cyclopropyl, R 4c is hydrogen or hydroxy, or a pharmaceutically acceptable salt thereof.

[0186] In a particularly preferred embodiment, the present invention provides 4 C3-C 10 or a pharmaceutically acceptable salt thereof.

[0187] In a particularly preferred embodiment, the present invention provides 4 is cyclopropyl.

[0188] In one embodiment, the present invention provides A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C6-C 14 -Aryl, C3-C 10 - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CHR 8 -, -CH2O-, -OCH2-, -CH2NR 13a -, -NR 13bselected from CH2-, -CH2CH2-, -CH2NHCH2-, -CH2NHCO-, -O-, -NH-, -SON2NH-, -NHSO2-, -SON2NHCH2-, -CH2NHSO2-, -SO2-, -NHC(O)- and -C(O)NH-; L 2 is selected from a covalent bond, —CH—, —NH—, —N(C1-C6-alkyl)-, —O—, —CH2NH—, —NHCH2—, —CHO—, and SO2—; R 1 But, [ka] selected from C-C-alkyl-SO—NH—, C-C-alkyl-SO—, and halo-C-C-alkyl-C(O)—; R 2 is selected from hydrogen and hydroxy; R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a is halo-C1-C6-alkyl and R 4b is hydroxy and R 4c is hydrogen, or R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is hydrogen or hydroxy, R 5is hydrogen, hydroxy, halogen, C1-C6-alkyl, C1-C6-alkoxy, carbonyl-C1-C6-alkyl, carboxy-C1-C6-alkyl, carbonyl-C1-C6-alkoxy, oxo, NH2-SO2-, C1-C6-alkyl-SO2-, carbonyl-C1-C6-alkyl-SO2-, C1-C6-alkyl-NH-C(O)-, carboxy, C1-C6-alkoxycarbonyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl-, (C1-C6-alkyl)2P(O)-C1-C6-alkyl-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen, cyano, oxo, C-C-alkoxy, halo-C-C-alkyl, and C-C-alkyl-SO-, R 7 is selected from hydrogen, C1-C6-alkyl, R 8 is selected from hydrogen and carbamoyl; R 9 is hydrogen, halogen, hydroxy, oxo, carboxy, C1-C6-alkoxycarbonyl, carbamoyl, C1-C6-alkyl-NH-C(O)-, C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C3-C 10 -cycloalkyl, cyano, C1-C6-alkyl-SO2-, and 5- to 14-membered heteroaryl, 10 -cycloalkyl and 5- to 14-membered heteroaryl may be substituted by one substituent selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10is selected from hydrogen, halogen, C-C-alkyl, halo-C-C-alkyl and oxo, R 11 is selected from hydrogen and halogen; R 12 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 13a But hydrogen, C3-C 10 -Cycloalkyl, C3-C 10 -cycloalkyl-C1-C6-alkyl-, R 13b is hydrogen, or a pharmaceutically acceptable salt thereof.

[0189] In a preferred embodiment, the present invention comprises: A, [ka] is selected from B is C6-C 14 -Aryl, C3-C 10 -cycloalkyl, and 5- to 14-membered heteroaryl; C is C3-C 10 - selected from cycloalkyl and 5- to 14-membered heteroaryl; L 1 is a covalent bond, -CHR 8 -, -CH2O-, and -SO2-; L 2 is selected from a covalent bond and —CHNH—; R 1 But, [ka] and R 2 is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R4b R 4c ) and R 4a and R 4b together with the carbon atoms to which they are attached, form C3-C 10 - forms a cycloalkyl, R 4c is hydrogen or hydroxy, R 5 is halogen, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkyl-SO2-, halo-C1-C6-alkyl-SO2-, [ka] and groups [ka] is selected from R 6 is selected from hydrogen, halogen and cyano; R 7 is hydrogen, R 8 is hydrogen, R 9 is selected from C1-C6-alkyl and halo-C1-C6-alkyl, R 10 is selected from hydrogen and halo-C1-C6-alkyl, R 11 is hydrogen, R 12 is halo-C1-C6-alkyl, or a pharmaceutically acceptable salt thereof.

[0190] In a particularly preferred embodiment, the present invention comprises: A, [ka] is selected from B is selected from phenyl, bicyclo[1.1.1]pentane, pyridyl, oxazolyl, pyrimidine, pyrazine, pyridazine, 1,2,4-thiadiazole, pyrazolyl, imidazolyl, and 1H-1,2,4-triazole; C is selected from cyclopropyl, pyrazolyl, and 1,3,4-oxadiazole; L 1 is a covalent bond, -CR 8 R 9 -, -CH2O-, and -SO2-; L 2 is selected from a covalent bond and —CHNH—; R 1 But, [ka] and R 2 is hydrogen, R 3 is hydrogen, R 4 is the group -C(R 4a R 4b R 4c ) and R 4a and R 4b together with the carbon atom to which they are attached form cyclopropyl, R 4c is hydrogen or hydroxy, R 5 Chloro, fluoro, CF3, CF3O, methylsulfonyl, CF3-SO2-, groups [ka] and groups [ka] is selected from R 6 is selected from hydrogen, fluoro and cyano; R 7is hydrogen, R 8 is hydrogen, R 9 is selected from methyl, 2,2-dimethylpropyl, and CF3; R 10 is selected from hydrogen and CF3; R 11 is hydrogen, R 12 is CF3, or a pharmaceutically acceptable salt thereof.

[0191] In one embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is selected from: [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-fluoro-5-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-fluoro-5-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-fluoro-2-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-fluoro-2-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(2,4-difluorophenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(4-methyl-4-oxo-1,4λ5-azaphosphinan-1-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-3-(trifluoromethyl)benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]amino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[1-(trifluoromethyl)cyclopropyl]-2-azaspiro[3.3]heptane-6-carboxamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[2-(trifluoromethyl)pyrimidin-4-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(1,1-dioxothiolan-3-yl)amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(3-hydroxy-3-methyl-azetidin-1-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)azetidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethylsulfonyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonyl)phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-fluoro-5-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2,4-difluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(3,4-difluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [2-(2-chloro-4-fluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2-methoxyphenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[5-(trifluoromethyl)-3-pyridyl]sulfonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-methylsulfonyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-methylsulfonyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(methylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(methylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (rac)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (S)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (R)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (R)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (S)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-fluoro-4-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[5-(trifluoromethyl)pyrimidin-2-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-(5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[[6-(difluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6R)-6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6R)-6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; 5-[[rac-(6S)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]oxy]-2-(trifluoromethyl)pyridine-4-carbonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[4-methylsulfonyl-3-(trifluoromethyl)phenoxy]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzenesulfonamide; Methyl 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzoate; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzoic acid; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-N-methyl-benzamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-[1-(methoxymethyl)-1,2,4-triazol-3-yl]phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-[1-(methoxymethyl)imidazol-2-yl]phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(4-methylsulfonylphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(3-methylsulfonylphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-fluoro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-chloro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethoxy)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-chloro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethoxy)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[3-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[3-chloro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-fluoro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[5-chloro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[cyclopropyl-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]amino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[cyclopropylmethyl-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]amino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-3-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-2-fluoro-4-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-4,4-difluoro-cyclohexanesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-3-(trifluoromethoxy)benzenesulfonamide; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoroethoxy)pyrazol-1-yl]azetidin-1-yl]methanone; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-3-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-3-(trifluoromethyl)benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2,2-dimethylpropylsulfonyl)-2,6-diazaspiro[3.3]heptan-6-yl]methanone; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-(1-methylcyclopropyl)-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[(4-fluorophenyl)methyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[1-(trifluoromethyl)cyclopropyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[[1-(trifluoromethyl)cyclopropyl]methyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 1-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]-2,2,2-trifluoroethanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4,4-difluoro-1-piperidyl)methyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-1-(trifluoromethyl)cyclopropanecarboxamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-4-(trifluoromethyl)benzenesulfonamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-2-(trifluoromethyl)benzenesulfonamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-2,2-dimethyl-propane-1-sulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-(2,2,2-trifluoro-1-hydroxy-ethyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-[(1R)-2,2,2-trifluoro-1-hydroxy-ethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-[(1S)-2,2,2-trifluoro-1-hydroxy-ethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]pyridazin-3-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[1-(trifluoromethyl)cyclopropyl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-fluoro-4-(trifluoromethoxy)phenyl]azetidin-1-yl]methanone; [3-[3-fluoro-4-(trifluoromethoxy)phenyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonyl)phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoroethyl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methyl]-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-3-yl]azetidin-1-yl]methanone; [3-(2-chloro-4-isopropylsulfonyl-phenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-4-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-4-fluorobenzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]-4-(trifluoromethoxy)benzenesulfonamide; 4-chloro-N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]benzenesulfonamide; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methylamino]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methylamino]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]methylamino]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3R)-3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3S)-3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(3S)-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(3R)-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[rac-(3R)-3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[rac-(3S)-3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]amino]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-diisopropylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [3-[4-(3-tert-butyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; (4R) or (4S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)piperidin-2-one; (4S) or (4R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)piperidin-2-one; [7-(5-chloro-3-fluoro-2-pyridyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(4-chloro-2-fluoro-phenyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)pyridin-2-one; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-(5-spiro[3.3]heptan-2-ylpyrazin-2-yl)azetidin-1-yl]methanone; [3-[4-(5-cyclopropyl-3-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-cyclopropyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2,2-difluoro-5-azaspiro[2.4]heptan-5-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(6-oxa-2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-hydroxy-3-(trifluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[3-(trifluoromethyl)azetidin-1-yl]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(5-oxa-2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-dimethylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(hydroxymethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2-oxaspiro[3.3]heptan-6-yl)-3-pyridyl]azetidin-1-yl]methanone; 4-Methylbenzenesulfonic acid; [3-(4-cyclobutyl-3-methylsulfonyl-phenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(1-hydroxy-1-methyl-ethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2,2-dimethylpropyl)-3-pyridyl]azetidin-1-yl]methanone; (trans)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)cyclobutyl]-3-pyridyl]azetidin-1-yl]methanone; (trans)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(difluoromethyl)cyclobutyl]-3-pyridyl]azetidin-1-yl]methanone; [3-[6-(2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2-oxa-7-azaspiro[3.4]octan-7-yl)-3-pyridyl]azetidin-1-yl]methanone; trans-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; cis-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-hydroxy-3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; 2-Cyclopropyl-6-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxy-benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [3-(4-cyclopropylphenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-(4-cyclopropyl-2-fluoro-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(trifluoromethyl)pyridazin-3-yl]oxyazetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethoxy)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; 5-Cyclopropyl-2-[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxy-benzonitrile; Methyl 2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxyphenyl]-2-methyl-propanoate; [3-[3-cyclopropyl-4-(trifluoromethyl)phenoxy]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(2-chloro-4-fluoro-phenyl)methoxy]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[3-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; [3-(3-cyclopropyl-2-fluoro-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethyl)phenoxy]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-(4-chloro-3-cyclopropyl-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4,4-difluorocyclohexyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(6,6-difluoro-3-bicyclo[3.1.0]hexanyl)methoxy]azetidin-1-yl]methanone; [3-[(6-chloro-5-cyclopropyl-3-pyridyl)oxy]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-(trifluoromethyl)-3-pyridyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(2-fluoro-4-methylsulfonyl-phenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[1-(trifluoromethyl)cyclopropyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[6-(trifluoromethyl)-3-pyridyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(3-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(2-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-(2,2,2-trifluoro-1-hydroxyethyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-chloro-2-methylsulfonyl-phenyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [[3-[4-(2-chloro-4-methylsulfonyl-phenyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; Methyl 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzoate; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2,2-trifluoroethyl)-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [3-[3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(2,5-dichlorophenoxy)-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenoxy]methyl]azetidin-1-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.5]nonan-7-yl]-3-(trifluoromethoxy)benzenesulfonamide; [3-[2-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(5-chloro-2-methylsulfonyl-phenoxy)-2-azaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]methylamino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(2-chloro-4-fluoro-phenoxy)methyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(4-fluoro-2-methylsulfonyl-phenoxy)-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(2-chloro-4-fluorophenyl)sulfonyl-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[(3-methyl-1,1-dioxo-thietan-3-yl)amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.5]nonan-7-yl]-4,4-difluoro-cyclohexanesulfonamide; 2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[[1-(trifluoromethyl)cyclopropyl]methyl]-2-azaspiro[3.3]heptane-6-carboxamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[1-[[4-(trifluoromethyl)phenyl]methyl]azetidin-3-yl]azetidin-1-yl]methanone; [3-[(4-chlorophenyl)methyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-2-(4-fluorophenyl)acetamide; [(3aR,6aS)-2-benzyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[(1,1-dioxothietan-3-yl)amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-[1-(2-tert-butyltetrazol-5-yl)cyclopropyl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)phenyl]azetidin-1-yl]methanone; [3-[6-(2-chlorophenoxy)-3-pyridyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(2,2-dimethylpropyl)triazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-(trifluoromethyl)pyrazin-2-yl]oxyphenyl]azetidin-1-yl]methanone; [3-[4-(benzenesulfonyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; Methyl 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxylate; [3-(4-cyclohexylsulfonylphenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[6-(2-chlorophenoxy)-3-pyridyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]methoxy]phenyl]azetidin-1-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-[1-(trifluoromethyl)cyclopropyl]-4H-1,2,4-triazol-3-yl]phenyl]azetidin-1-yl]methanone; [3-[6-(2-chlorophenoxy)pyridazin-3-yl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(1H-tetrazol-5-yl)cyclopropyl]phenyl]azetidin-1-yl]methanone; 4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(dimethylphosphorylmethyl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(4-isopropyl-N-methyl-anilino)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(N-methylanilino)-3-pyridyl]azetidin-1-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]piperidine-2-carboxamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4,4-difluoro-piperidine-2-carboxamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; 2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxyphenyl]-2-methyl-propanoic acid; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzoic acid; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-N-ethyl-benzamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxylic acid; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]piperidine-2-carboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4,4-difluoro-piperidine-2-carboxamide; (2R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-4,4-difluoro-piperidine-2-carboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; (2R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; [3-(6-tert-butyl-3-pyridyl)azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; Bis[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-ylidene]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylphenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-benzyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(2-tert-butylthiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-(2-hydroxy-2-methylpropyl)indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-triflylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[3-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethyl)thiazol-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-(2,2,2-trifluoroethyl)-2-pyridone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethyl)phenyl]sulfonimidoyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methoxy]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isothiazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[3-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[3-(5-neopentyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[[1-(trifluoromethyl); Cyclopropyl]amino]methyl]pyrazin-2-yl]azetidin-1-yl)methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[difluoro-[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(5-ethoxy-3-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-thiadiazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(2-fluoro-4-triflyl-benzyl)-2,6-diazaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-chloro-2-mesyl-phenyl)phenyl]azetidin-1-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)phenyl]sulfonimidoyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[3-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-dimethylphosphoryl-2-fluoro-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]-5-fluoro-benzonitrile; 3-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]; Pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methoxy]pyrazin-2-yl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-2-pyridyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-1-bicyclo[1.1.1]pentanyl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl-sulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(8S)-8-methyl-8-oxo-8λ6-thia-9-azatricyclo[8.4.0.02,7]tetradeca-1(10),2(7),3,5,8,11,13-heptaen-12-yl]azetidin-1-yl]methanone; 2-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(8R)-8-methyl-8-oxo-8λ6-thia-9-azatricyclo[8.4.0.02,7]tetradeca-1(10),2(7),3,5,8,11,13-heptaen-12-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-6-keto-nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-(methylsulfonimidoyl)-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[(4-tert-butyloxazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethoxy)phenyl]sulfonyl-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-fluoro-benzonitrile; [6-[(5-tert-butyl-1,3,4-thiadiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-cyclopropylthiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(cyclopropylsulfonimidoyl); Phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(5-fluoro-3-pyridyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[3-(5-neopentyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]oxy]-2-(trifluoromethyl)benzonitrile; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(4-mesylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl); Cyclopropyl]methylamino]pyrazin-2-yl]azetidin-1-yl)methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(4-cyclopropylsulfonylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(difluoromethyl)thiazol-2-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-Fluoro-2-[3-[1-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]benzonitrile; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-keto-nicotinonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3-cyclopropyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2-mesylphenyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[1-(2-hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-1H-imidazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methylsulfonyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[3-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethoxy)phenyl]sulfonyl-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-methyl-imidazole-4-carbonitrile; [2-(4-chloro-2-mesyl-phenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-triflylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1-methylpyrazol-4-yl)oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)tetrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[4-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(trifluoromethyl)pyrazin-2-yl]oxy-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(2-fluoro-4-triflyl-benzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-ethoxy-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(4-chloro-2-mesyl-phenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1h-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[6-(trifluoromethyl)-3-pyridyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-(2,2,2-trifluoroethyl)-2-pyridone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethoxy)phenyl]sulfonimidoyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[2-fluoro-4-(trifluoromethyl-sulfonimidoyl)benzyl]oxyazetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-phenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)-cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 3-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-methyl-pyrazole-3-sulfonamide; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(2,4-difluorobenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-cyclopropyl-3-methyl-pyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-cyclopropyl-3-methyl-pyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[(4-tert-butylisoxazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-methyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2-difluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-(methylamino)-1,3,4-thiadiazol-2-yl]phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]oxy]-2-(trifluoromethyl)benzonitrile; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-cyclobutylthiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[(6S)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclobutyl-1H-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-[(3-chloro-5-fluoro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-2-methyl-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-([1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-(trifluoromethyl)pyrimidin-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]oxyazetidin-1-yl]methanone; [6-[2-mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-1,2,4-thiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)oxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-([1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-hydroxy-1,2,4-triazol-1-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(difluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(4-tert-butyl-1H-imidazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(methylsulfonimidoyl)-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3R)-3-(trifluoromethyl)pyrrolizino]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[(6R)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-mesyl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(4-fluorophenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)isothiazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-dimethylphosphoryl-5-fluoro-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)-2-pyridyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazolo[4,3-b]pyridin-5-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-fluoro-2-mesyl-phenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[(3-cyclopropyl-5-methyl-isoxazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(2,2,2-trifluoroethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazolo[4,3-b]pyridin-5-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrimidin-2-yl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(2,2,2-trifluoroethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-[[(6S)-2-[6-[3-(1-hydroxy-cyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]oxy]-2-(trifluoromethyl)isonicotinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]-amino]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)oxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3-cyclopropyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(4-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-fluoro-5-methoxyphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro-[3.3]heptan-2-yl]-[4-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo-[1.1.1]pentanyl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(trifluoromethyl)pyrazin-2-yl]oxy-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3S)-3-(trifluoromethyl)pyrrolizino]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3,5-dimethylpyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-(4-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-pyridone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethyl)phenyl]sulfonyl-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[4-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(difluoromethoxy)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3,5-dimethylpyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)phenoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[[3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethylsulfonimidoyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-tert-butylthiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-fluoro-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(1,1-difluoroethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(cyclopropylsulfonimidoyl)phenyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1,2,4-triazol-1-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro-[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3,5-diisopropylpyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-fluoro-4-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]benzonitrile; [6-[3-Mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethoxy)-2-pyridone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-fluoro-3-pyridyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-ethyl-1,2,4-thiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)oxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-4-(trifluoromethyl)pyridin-2-one; 5-chloro-2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]-N-ethyl-benzamide; [6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-fluoro-benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-fluorophenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-mesylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-6-(trifluoromethyl)picolinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2-mesylphenyl)phenyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-methylsulfonylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-mesylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-[[1-(trifluoromethyl); Cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-imidazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-fluoro-4-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[difluoro-[4-(trifluoromethyl)-phenyl]methyl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazol-3-ylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,5-dimethylthiazol-4-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-mesyl-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)-3-pyridyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(4-methylimidazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]-sulfonyl]-1-bicyclo[1.1.1]pentanyl]-azetidin-1-yl]methanone; 5-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-mesyl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[5-(trifluoromethyl)pyrazin-2-yl]amino]cuban-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-neopentyltriazol-4-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-tert-butyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-cyclopropyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[2-mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-N-[[6-(trifluoromethyl)-3,4-diazatricyclo[7.1.1.03,7]undeca-4,6-dien-1-yl]methyl]-2-azaspiro[3.3]heptane-2-carboxamide; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)-3-pyridyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-cyclopropylimidazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-(2,4-difluorobenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[3-methyl-5-(trifluoromethyl)-2-pyridyl]oxy]-7-azaspiro[3.5]nonan-7-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-dimethylphosphoryl-2-methyl-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-[5-cyclopropyl-3-(difluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[4-(1-hydroxyethyl)-5-methyl-thiazol-2-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-dimethyl-1,2,4-triazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[6-(trifluoromethyl)-3-pyridyl]methyl]piperazino]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[fluoro-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-3-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-5-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)phenoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 3-[[2-[6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethoxy)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2-hydroxyethyl)-3-(trifluoromethyl)pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(4-cyclopropylsulfonylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-3-methoxy-benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-dimethylphosphoryl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-[(2S)-3,3,3-trifluoro-2-hydroxy-propyl]indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-propyl]indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[6-(trifluoromethyl)-3-pyridyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [7-(4-chloro-2-mesyl-phenyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(4-ethylphenyl)methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-[5-(2-pyridyl)-2-thienyl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-[4-(methylamino)phenyl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(4-methyl-2-thienyl)methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-[3-cyclopropyl-5-(difluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[5-(trifluoromethyl)-2-pyridyl]methyl]piperazino]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-dimethylthiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[(2-methyloxazol-4-yl)methyl]piperazino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[(4-methylthiazol-5-yl)methyl]piperazino]methanone; [4-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]piperazino]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-3-methyl-pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-dimethylphosphoryl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-3-methoxy-benzamide; [6-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(pyrazolo[1,5-a]pyridin-3-ylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-mesyl-4-(trifluoromethyl)benzyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-dimethylphosphoryl-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(4-chloro-2-methoxy-benzyl)-methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-benzyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[(4-chloro-2-methoxy-benzyl)-methylamino]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[(4-chloro-2-methoxy-benzyl)-methylamino]methyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylthiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylthiazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1,5-dimethylpyrazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-dimethyloxazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-chloro-2-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methoxy]nicotinamide; [6-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylpyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1-methylpyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[6-(trifluoromethyl)-3-pyridyl]oxymethyl]piperidino]methanone; 4-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-2-methoxy-benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-fluoro-4-(trifluoromethoxy)benzyl]oxypiperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-fluoro-4-(trifluoromethyl)benzyl]oxypiperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-mesyl-4-(trifluoromethyl)benzyl]-oxypiperidino]methanone; 5-chloro-2-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methoxy]nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(2-methylsulfonylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 4-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-1H-triazole-5-carbonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzoic acid methyl ester; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzoic acid methyl ester; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzamide; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzamide; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [4-[[4-fluoro-3-(trifluoromethyl)phenoxy]methyl]piperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethoxy)phenoxy]methyl]piperidino]methanone; [4-(2-chloro-4-mesyl-benzyl)oxypiperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethyl)phenoxy]methyl]-piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [4-[[3-fluoro-5-(trifluoromethyl)phenoxy]methyl]piperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[4-mesyl-3-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethoxy)phenoxy]methyl]-piperidino]methanone; [6-(5-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[4-mesyl-3-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [4-(2-chloro-4-mesyl-benzyl)oxypiperidino]-[6-(5-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-dimethylphosphorylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [3-[3-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-fluorophenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-fluorophenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-fluorophenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-cyclopropyl-1,2,4-triazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-dimethylphosphorylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(5-fluoro-3-pyridyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[6-(2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-mesylphenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[4-(trifluoromethyl)-2-pyridyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methoxy-5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]methyl]-5-(trifluoromethyl)-2-pyridone; 1-[[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]methyl]-4-(trifluoromethyl)-2-pyridone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-triflylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(methylsulfonimidoyl)-3-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-mesylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(difluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(difluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)pyrazin-2-one; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(2,2,2-trifluoroethoxy)-3-pyridyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-isopropoxy-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1S)-1-[4-methyl-5-(trifluoromethyl)-2-pyridyl]ethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1#H!-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1#R!)-1-[4-methyl-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-triflylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]oxymethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(3,3,3-trifluoropropyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-[difluoro-[4-(trifluoromethyl)phenyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-methyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-mesyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(3-fluorophenyl)methanone; 4-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-2-methoxy-benzamide; [3-[4-(2-chloro-4-mesyl-phenyl)phenyl]azetidin-1-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[2-fluoro-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[4-mesyl-3-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-indazol-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazo[1,2-a]pyrazin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)imidazo[1,5-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-indazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; and [6-(3-Cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0192] In a preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is selected from: [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl); 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]-amino]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethylsulfonimidoyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-[[1-(trifluoromethyl); [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[fluoro-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-3-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-5-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-triflylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)pyrazin-2-one; and [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0193] In particularly preferred embodiments, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is selected from: [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0194] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein or a pharmaceutically acceptable salt thereof, wherein the compound is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0195] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0196] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0197] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0198] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0199] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone.

[0200] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0201] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0202] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0203] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0204] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0205] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0206] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein or a pharmaceutically acceptable salt thereof, wherein the compound is [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0207] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

[0208] In a particularly preferred embodiment, the present invention provides a compound of formula (I) as described herein, or a pharmaceutically acceptable salt thereof, wherein said compound of formula (I) is [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone. In certain embodiments, the present invention provides pharmaceutically acceptable salts of compounds according to formula (I) described herein. In more particular embodiments, the present invention provides compounds according to formula (I) described herein as the free base.

[0209] In some embodiments, compounds of formula (I) are isotopically labeled by replacing one or more atoms therein with atoms having a different atomic mass or mass number. Such isotopically labeled (i.e., radiolabeled) compounds of formula (I) are considered to be within the scope of the present disclosure. Examples of isotopes that may be incorporated into compounds of formula (I) include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, chlorine, and iodine, respectively, e.g., 2 H, 3 H, 11 C. 13 C. 14 C. 13 N, 15 N, 15 O. 17 O. 18 O. 31 P, 32 P, 35 S, 18 F,36 Cl, 123 I, and 125 Certain isotopically labeled compounds of formula (I), for example those incorporating a radioactive isotope, are useful in drug and / or substrate tissue distribution studies. The radioactive isotope tritium, i.e., 3 H and carbon-14, i.e., 14 C are particularly useful for this purpose given their ease of incorporation and ready means of detection. For example, compounds of formula (I) can be enriched with 1, 2, 5, 10, 25, 50, 75, 90, 95, or 99% of a given isotope.

[0210] Heavier isotopes, such as deuterium, i.e. 2 Substitutions such as H may result in greater metabolic stability and may confer certain therapeutic advantages, for example, by increasing in vivo half-life or requiring lower dosages. 11 C. 18 F, 15 O and 13 Substitution with positron emitting isotopes, such as N, can be useful in positron emission tomography (PET) studies for examining substrate receptor occupancy. Isotopically labeled compounds of formula (I) can generally be prepared by conventional techniques known to those skilled in the art, or by methods analogous to those described in the Examples set forth below, substituting an appropriate isotopically labeled reagent for the previously employed non-isotopically labeled reagent.

[0211] Manufacturing method The preparation of the compounds of formula (I) of the present invention can be carried out by sequential or convergent synthetic routes. The synthesis of the present invention is shown in the following general scheme. The skills required to carry out the reactions and purification of the resulting products are known to those skilled in the art. The substituents and indices used in the following process descriptions have the meanings given herein unless indicated to the contrary.

[0212] If one of the starting materials, intermediates, or compounds of formula (I) contains one or more functional groups that are not stable or reactive under the reaction conditions of one or more reaction steps, suitable protecting groups (such as those described in "Protective Groups in Organic Chemistry," by T.W. Greene and P.G.M. Hutts, 5th Edition, 2014, John Wiley & Sons, NY) may be introduced prior to a critical step by applying methods well known in the art. Such protecting groups may be removed at a later stage of the synthesis using standard methods described in the literature.

[0213] When the starting material or intermediate contains a stereocenter, the compound of formula (I) is obtained as a mixture of diastereomers or enantiomers, which can be separated by methods known in the art, such as chiral HPLC, chiral SFC, or chiral crystallization. Racemates can be separated into their antipodes via diastereomeric salts, for example, by crystallization with an optically pure acid, or by separating the antipodes by specific chromatographic methods using either a chiral adsorbent or a chiral eluent. Starting materials and intermediates containing a stereocenter can also be separated to obtain diastereomerically / enantiomerically enriched starting materials and intermediates. The use of such diastereomerically / enantiomerically enriched starting materials and intermediates in the synthesis of the compound of formula (I) generally results in the respective diastereomerically / enantiomerically enriched compounds of formula (I).

[0214] Those skilled in the art will recognize that in the synthesis of compounds of formula (I), unless otherwise desired, an "orthogonal protecting group strategy" may be applied to cleave some protecting groups one at a time without affecting other protecting groups in the molecule. The principle of orthogonal protection is well known in the art and has been described in the literature (e.g., Barany and R.B. Merrifield, J. Am. Chem. Soc. 1977, 99, 7363; H. Waldmann et al., Angew. Chem. Int. Ed. Engl. 1996, 35, 2056).

[0215] Those skilled in the art will recognize that the reaction sequence may vary depending on the reactivity and nature of the intermediates.

[0216] More specifically, compounds of formula (I) can be prepared by the methods described below, the methods described in the Examples, or similar methods. Appropriate reaction conditions for the individual reaction steps are known to those skilled in the art. For literature-described reaction conditions that affect the described reactions, see, for example, "Comprehensive Organic Transformations: A Guide to Functional Group Preparations, 2nd Edition, Richard C. Larock, John Wiley & Sons, New York, NY, 1999." The reactions could be easily carried out with or without a solvent. There are no particular restrictions on the nature of the solvent used, so long as it does not adversely affect the reaction or the reagents involved and is capable of dissolving the reagents to at least some extent. The described reactions can occur over a wide range of temperatures, and the exact reaction temperature is not critical to the present invention. It is convenient to carry out the described reactions at temperatures ranging from -78°C to reflux. The reaction time required for the reaction can also vary widely, depending on many factors, particularly the reaction temperature and the nature of the reagents. However, a period of 0.5 hours to several days is usually sufficient to obtain the intermediates and compounds described. The reaction order is not limited to the order shown in the scheme, but the order of the reaction steps can be freely changed depending on the starting materials and their respective reactivities.

[0217] If the starting materials or intermediates are not commercially available or their synthesis is not described in the literature, they can be prepared analogously to existing procedures for similar analogs or as outlined in the experimental section.

[0218] The following abbreviations are used herein:

[0219] AcOH = acetic acid, ACN = acetonitrile, Bn = benzyl, BINAP = (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl), Boc = tert-butyloxycarbonyl, CAS RN = Chemical Abstracts Registry Number, Cbz = benzyloxycarbonyl, CDI = N,N'-carbonyldiimidazole, Cs2CO3 = cesium carbonate, CO = carbon monoxide, CuCl = copper(I) chloride, CuCN = copper(I) cyanide, CuI = copper(I) iodide, DABCO = 1,4-diazabicyclo[2.2.2]octane; triethylenediamine, DAST = (diethylamino)sulfur trifluoride, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene, DEAD = diethyl azodicarboxylate, DIAD = diisopropyl azodicarboxylate, DIBAL-H = diisobutylaluminum hydride, DMAP = 4-dimethylaminopyridine, DME = dimethoxyethane, D MEDA = N,N'-dimethylethylenediamine, DMF = N,N-dimethylformamide, DIPEA = N,N-diisopropylethylamine, dppf = 1,1-bis(diphenylphosphino)ferrocene, EDC.HCl = N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, EI = electron impact, ESI = electrospray ionization, EtOAc = ethyl acetate, EtOH = ethanol, h = hour, FA = formic acid, H2O = water, H2SO4 = sulfuric acid, HATU = 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate, HBTU = O-benzotriazole-N,N,N'N'-Tetramethyl-uronium-hexafluorophosphate, HCl = hydrogen chloride, HOBt = 1-hydroxy-1H-benzotriazole; HPLC = high performance liquid chromatography, iPrMgCl = isopropyl magnesium chloride, I2 = iodine, IPA = 2-propanol, ISP = ion spray positive (mode), ISN = ion spray negative (mode), K2CO3 = potassium carbonate, KHCO3 = potassium bicarbonate, KI = potassium iodide, KOH = potassium hydroxide, K3PO4 = lithium tripotassium phosphate, LiAlH4 or LAH = lithium aluminum hydride, LiHMDS = lithium bis(trimethylsilyl)amide, LiOH = lithium hydroxide, mCPBA = meta-chloroperoxybenzoic acid, MgSO4 = magnesium sulfate, min = minutes, mL = milliliters, MPLC = medium pressure liquid chromatography, MS = mass spectrum, MTBE = methyl tert-butyl ether, nBuLi = n-butyllithium, NaBH3CN = sodium cyanohydride, NaH = sodium hydride , NBS = N-bromosuccinimide, NaHCO3 = sodium bicarbonate, NaNO2 = sodium nitrite, NaBH(OAc)3 = sodium triacetoxyborohydride, NaOH = sodium hydroxide, Na2CO3 = sodium carbonate, Na2SO4 = sodium sulfate, Na2S2O3 = sodium thiosulfate, NEt3 = triethylamine (TEA), NH4Cl = ammonium chloride, NMP = N-methyl-2-pyrrolidone, OAc = acetoxy, T3P = propylphosphonic anhydride, PE = Petroleum ether, PG = protecting group, Pd-C = palladium on activated carbon, PdCl2(dppf)-CH2Cl2 = 1,1'-bis(diphenylphosphino)ferrocene-palladium(II) dichloromethane complex, Pd2(dba)3 = tris(dibenzylideneacetone)dipalladium(0), Pd(OAc)2 = palladium(II) acetate, Pd(OH)2 = palladium hydroxide, Pd(PPh3)4 = tetrakis(triphenylphosphine)palladium(0), PE = petroleum ether, PMP = 1,2,2,6,6-pentamethylpiperidine, PTSA = p-toluenesulfonic acid, R = any group, RP = reverse phase, RT = room temperature, SFC = supercritical fluid chromatography, S-PHOS = 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl, TBAI = tetrabutylammonium iodide, TEA = triethylamine, TFA = trifluoroacetic acid, THF = tetrahydrofuran, TMEDA = N,N,N',N'-tetramethylethylenediamine, TS-TPP = triphenylphosphine-polymer-bound, XPhos = 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl, ZnCl2 = zinc chloride, Hal = halogen, prep-TLC = preparative thin layer chromatography.

[0220] The present compounds of formula I can be prepared by reacting an activated intermediate of formula 2 with a nucleophilic spirocyclic amine 1 by heating in the presence of a base such as DIPEA in a solvent such as DMF or CHCN (Scheme 1). [ka] Scheme 1

[0221] The activated intermediate 2 can be generated either transiently in the reaction mixture or by reacting amine 3 with a coupling agent such as di(1H-1,2,4-triazol-1-yl)methanone in a solvent such as CH2Cl2 in the presence of a base such as DIPEA (Scheme 2). [ka] Scheme 2

[0222] Building blocks of formula 4 where L1 = CH2 can be generated by Suzuki reaction (e.g., (Pd(dppf)Cl2, K2CO3, dioxane / HO)), (X = Br, I), followed by hydrogenation (e.g., Pd / C, H2). The required boronate intermediate 5 can be generated by reacting the ketone with 4,4,5,5-tetramethyl-2-[(tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane (LiTMP, THF, -78 °C). (Scheme 3) When B = N-linked heteroaryl, a Chan-Lam-type coupling can be used instead of the Suzuki reaction (e.g., using Cu(OAc)2 under an oxygen atmosphere), followed by hydrogenation / deprotection. A similar sequence can also be used to generate building blocks where L1 = -CH(Me)-, bearing an additional Me group on the alkene carbon bearing the boronate, for example, starting from an appropriately functionalized boronate 5. [ka] Scheme 3

[0223] The building blocks of formula 8, where L1 = bond and B = C-linked (hetero)aryl, can be generated by nickel- or palladium-catalyzed coupling of appropriately protected boronic acid derivatives 9 (X = B(OR)2) with iodides or bromides (Y = I or Br) 10. Alternatively, bromides 9 (X = Br) can be directly coupled with 10 (Y = I or Br) via photochemical reaction using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2.DME, dtbbpy, and (TMS)3SiH (Scheme 4). Alternatively, cross-coupling can be carried out under Negishi conditions using a zincate transiently generated from 10 (Y = I) and a (hetero)aryl halide (X = I, Br); or by reaction of a p-tolylsulfonylhydrazono derivative of 10 with boronic acid 9 (Y = B(OH)2). Alternatively, the C-linked heteroaryl ring B can be introduced using standard heterocyclic ring synthesis, typically starting from an acid or cyano derivative of the (spiro)cyclic amine A. [ka] Scheme 4

[0224] Alternatively, the components of formula 11 where L1=oxygen and B is (hetero)aryl (X is S N Ar substitution), in the presence of a base such as NaOtBu, 12 (X is a leaving group such as Cl, Br, and is typically S N Ar (adjacent to the aromatic N for the reaction) can be prepared by reacting with an appropriately protected alcohol building block 13, followed by deprotection under standard conditions (e.g., with TsOH when PG=Boc). (Scheme 5) The S of the leaving group X (typically OM, Br, or I) can be prepared using a base such as NaH. N A similar scheme can be used to introduce small aliphatic units such as cyclopropyl or aliphatic (hetero)cycles as ring B via disubstitution. Alternatively, building blocks of formula 11 where L1 = oxygen and B is (hetero)aryl can be generated by palladium-catalyzed cross-coupling of alcohol 13 with (hetero)aryl halide 12 (X = typically Br, I), followed by deprotection. [ka] Scheme 5

[0225] Alternatively, building blocks of formula 14 where L1 = NHC(O) can be prepared by reacting a suitably protected carboxylic acid 15 (or alternatively an acid chloride) with amine 16 to generate amide 17 using standard amide coupling techniques (e.g., HATU, EtN), followed by deprotection. Amide 17 can also be reduced (e.g., using borane-methylsulfide complex) prior to deprotection to give amine building blocks of formula 18. (Scheme 6) These two sequences are also suitable for introducing the B ring when L1 = -CH2NHCH2- or -CH2NHC(O)-, starting from amine building block 15 bearing a -CH2NH2 group instead of the amine. [ka] Scheme 6

[0226] Alternatively, building blocks of formula 19 where L1 = SO2NH can be prepared by reacting sulfonyl chloride 20 with an appropriately protected amine building block 21 in the presence of a base such as DIPEA, followed by deprotection under standard conditions (e.g., with TsOH or TFA when PG = Boc) (Scheme 7). [ka] Scheme 7

[0227] Alternatively, L1 = NH or CH2NH and B is (hetero)aryl (X is S N The components of formula 22 are 12 (X is a leaving group such as Cl, Br, etc., and S N Ar (often adjacent to an aromatic N for reaction) can be prepared by reaction with an appropriately protected amine building block 21 in the presence of a base such as DIPEA, followed by deprotection under standard conditions (e.g., with TsOH when PG=Boc) (Scheme 8). [ka] Scheme 8

[0228] Alternatively, building blocks of formula 22 where L1 = a bond and B is an N-linked heterocycle can be prepared by reacting the nucleophilic heterocycle B (24) with a suitably protected building block 25 (X = OMs, a leaving group such as I, Br, etc.) in the presence of a base such as Cs2CO3, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). (Scheme 9) Typically, a mesylate building block 25 is used (X = OMs), which can be conveniently generated from the hydroxyl analog by reaction with MsCl in the presence of a mild base such as Et3N. [ka] Scheme 9

[0229] Alternatively, components of formula 22 where L1 = a bond and B is an N-linked heterocycle can be prepared by reductive amination of heterocycle B (24) with an appropriately protected ketone component 26 in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 10). [ka] Scheme 10

[0230] Alternatively, building blocks of formula 27 where L1 = CH2N can be installed by reductive amination of amine 28 with an appropriately protected ketone building block 26 in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 11). [ka] Scheme 11

[0231] Alternatively, building blocks of formula 28, where L1 = CH2 and A is N-linked, can be prepared by reductive amination of aldehyde 29 with a suitably protected heterocycle A (30) in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). (Scheme 12) The same sequence can also be carried out to generate building blocks of formula 31, where L1 = CH2NH or CH2NHCH2, from aldehyde 29 and amine 21. (Scheme 12) L1 = CH2NR 13aThe building block 31a, where L = CHNR, can be generated by reductive amination of the aldehyde 29 with a suitably protected alkylamine building block 21a. Alternatively, L = CHNR 13a The building block 31a can be prepared by reductive amination of aldehyde 29 with a suitably protected amine building block 21a, followed by the addition of the amino group (e.g., CsCO) and an appropriate alkyl halide R 13a -X (where X = Br or I) in a solvent such as DMF) and deprotection (Scheme 13). [ka] Scheme 12

[0232] [ka] Scheme 13

[0233] Alternatively, building blocks of formula 32 where L1 = SO2 and A is N-linked can be prepared from sulfonyl chloride 33 and a suitably protected heterocycle A (30) in the presence of a base such as DIPEA, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). (Scheme 14) This sequence is also appropriate when A is N-linked and R1 is C1-C6-alkyl-SO2-. [ka] Scheme 14

[0234] Alternatively, building blocks of formula 11 where L1 = oxygen and B is (hetero)aryl (OH is positioned such that it is nucleophilic) can be prepared by reacting a suitably protected building block 13 (X is a leaving group such as Cl, Br, I, or OM) with alcohol 34 in the presence of a base such as NaH, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). (Scheme 15) S of the leaving group X (typically OM, Br, or I) with a small aliphatic alcohol. N A similar procedure can be used to introduce, via 2 substitution, a small aliphatic unit in place of the B ring, or an aliphatic (hetero) ring such as cyclopropyl as the B ring with an additional CH2 linker. [ka] Scheme 15

[0235] Alternatively, components of formula 28 where L = CH and A is N-linked can be prepared by reductive amination of a suitably protected heterocycle A (30) with (hetero)arylmethyl halides (X = Cl, Br, I) 35 in the presence of a base such as KCO in a solvent such as ACN, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 16). [ka] Scheme 16

[0236] Alternatively, building blocks of formula 28 where L=CH and A is N-linked can be prepared by reductive amination of acid chloride 36 with a suitably protected heterocycle A (30) in the presence of a base (e.g., DIPEA) to form the amide, followed by reduction of the amide (e.g., using borane tetrahydrofuran complex) and deprotection under standard conditions (e.g., with TsOH when PG=Boc) (Scheme 17). [ka] Scheme 17

[0237] Alternatively, sulfonylurea building blocks of formula 37, where L = -NHSO- or -CHNHSO-, can be prepared by activation of 2-methyl-1-(2-methylimidazol-1-yl)sulfonyl-imidazole by methylation with methyl trifluoromethanesulfonate, followed by reaction with an appropriately protected amine 30, a further activation sequence by methylation with methyl trifluoromethanesulfonate followed by reaction with amine 28, and finally deprotection under standard conditions (e.g., with TsOH or TFA when PG = Boc). (Scheme 18) Alternatively, sulfonylurea building block 37 can be generated from sulfuryl chloride, followed by the sequential addition of 30 and 28 in the presence of a base such as EtN or DIPEA, followed by final deprotection under standard conditions. [ka] Scheme 18

[0238] Alternatively, components of formula 38, where L1=bond, A is an N-bond, and B is a (hetero)aryl, can be prepared by metal-catalyzed cross-coupling of an appropriately protected heterocycle A (30) with a (hetero)aryl halide (X=Br, I, Cl) (e.g., Buchwald reaction, Pd catalyzed), followed by deprotection under standard conditions (e.g., with TsOH or TFA when PG=Boc). (Scheme 19) In a particular example, the (hetero)aryl 39 is S N When suitable for Ar reaction (X=F), the components of formula 38 can be converted to the S-type (spiro)cycles A30 and A39 in the presence of a base (e.g., K2CO3 or Et3N, DMSO, heat). N It can be produced by Ar reaction. [ka] Scheme 19

[0239] Alternatively, components of formula 40 where L1 = a bond and B is an N-linked heterocycle can be prepared by reductive amination of appropriately protected aldehydes 41 with heterocyclic amines 24 in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 20). [ka] Scheme 20

[0240] Alternatively, building blocks of formula 42 where L1 = C(O)NH could be prepared by reacting a suitably protected amine 44 with a carboxylic acid 43 to generate amide 45 using standard amide coupling techniques (e.g., HATU, DIPEA), followed by deprotection under standard conditions (e.g., with TsOH or TFA when PG = Boc) (Scheme 21). [ka] Scheme 21

[0241] Alternatively, components of formula 46, where L1 = bond, B = (hetero)aryl, L2 = bond, and C = cyclopropyl, can be generated by metal-catalyzed cross-coupling of appropriately protected halides 10 (Y = I, Br) with cyclopropyl (hetero)halides 49 (X = Br, Cl), such as the photochemical reaction of 10 (Y = Br) with 49 using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2.DME, dtbbpy, and (TMS)3SiH. 11 =H, and R 10When Y = CF, trifluoromethylcyclopropyl building block 49 is not commonly available and instead was generated from halide building block 47 (X1 = I, Br is typically adjacent to the aromatic N, where X2 = Br, which needs to be more reactive towards Suzuki reaction than Cl) by Suzuki reaction with 1-(trifluoromethyl)vinylboronic acid to give 48. Cyclopropanation with diphenyl(methyl)sulfonium tetrafluoroborate and LiHMDS afforded the required building block 49 (Scheme 22). Alternatively, the sequence of steps could be reversed so that the Negishi cross-coupling of 10 (Y = I) was first carried out with 47 (in this case, X1 needs to be less reactive towards cross-coupling than X2) to give intermediate 52 (Scheme 23), followed by the Suzuki-cyclopropanation sequence and deprotection. [ka] Scheme 22

[0242] Building blocks where L1 = bond, B = C-linked (hetero)aryl, and R5 = amine (L2 = -NH- or -CHNH-, where C is an aliphatic heterocycle such as cyclopropyl (50) or C=N-linked heterocycle (51)) can be generated by metal-catalyzed amination of intermediate 52 (X1 = Br, Cl adjacent to the aromatic N) with the relevant amine building block 53 or 54 (typically Pd-catalyzed, Buchwald reaction). The required intermediate 52 can be generated by cross-coupling, such as the Negishi reaction, between a temporarily generated, appropriately protected zincate salt of building block 10 (Y = I) and the appropriate dihalogenated (hetero)aryl building block 47 (X2 should be more reactive to cross-coupling conditions than X1; typically, X2 = I or Br, and X1 = Br). (Scheme 23) Alternatively, intermediate 52 can be generated by reacting the p-tolylsulfonylhydrazono derivative of 10 (Y = N-NH-Ts) with boronic acid 47 (X2 = B(OH)2) in the presence of a base such as K2CO3. [ka] Scheme 23

[0243] Alternatively, amines 53 or 54 can be reacted with S N The SNAr reaction with (hetero)aryl building block 47 (X1 = F) can be used to generate intermediates 55 or 56, followed by cross-coupling with the A ring (typically using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2.DME, dtbbpy, and (TMS)3SiH to photochemically react 10 (Y = Br) with halide 55 or 56) and subsequent deprotection. (Scheme 23) Alternatively, this SNAr approach to generating R5 amines can be carried out with intermediates such as 52 (where X1 = F). (Scheme 24) Optionally, copper-catalyzed S N Ar or Ullmann-type reactions were used in the reaction of 47 and 54 to give 56. [ka] Scheme 24

[0244] The building block where L1 = bond, B = C-linked (hetero)aryl, and C = N-linked heteroaryl (57) can be generated by Chan-Lam coupling of boronic acid 47 (X1 = B(OH)2, X2 = Br) with the heteroaryl in the presence of Cu(OAc)2 to give intermediate 56, which can then be reacted with an appropriately protected (spiro)cyclic amine 10 (Y = Br) in a photochemical cross-coupling using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2, DME, dtbbpy, and (TMS)3SiH), followed by deprotection (Scheme 25). Alternatively, in the case of C-linked heterocycles, heterocycle C can be constructed by standard heterocycle synthesis techniques prior to photochemical cross-coupling and deprotection. In some cases, the order of steps can be reversed. [ka] Scheme 25

[0245] Building blocks (58) where L1 = -CHO- can be generated from a suitably protected hydroxylated building block 13 and a (hetero)aryl building block 35 (X = typically Br) bearing a leaving group at the benzylic position by alkylation (e.g., using potassium tert-butoxide) followed by deprotection (e.g., with TsOH or TFA when PG = Boc). (Scheme 26) A similar approach can be used to introduce small alkyl units bearing an aliphatic B ring. [ka] Scheme 26

[0246] Alternatively, building blocks of formula 59, where L1 = oxygen and B is (hetero)aryl, can be prepared by reacting a suitably protected (spiro)cyclic amine (13) bearing a hydroxyl group with a nucleophilic (hetero)aryl alcohol (60) under Mitsunobu-type conditions (e.g., using Tsunoda reagent, (tributylphosphoranylidene)acetonitrile, or PPh3 / DIAD), followed by deprotection (Scheme 27). [ka] Scheme 27

[0247] Alternatively, building blocks of formula 61, where L1 is 1, L2 is a bond, and B and C are (hetero)aryl, can be prepared by reacting appropriately protected (spiro)cyclic amines (Y = I or Br) in two sequential cross-coupling reactions, followed by deprotection. Most typically, this involves Ni-catalyzed cross-coupling between 10 (Y = I) and building block 62, which bears both bromide and boronic acid functionalities, to give bromo(hetero)aryl intermediate 63. Intermediate 63 is coupled with boronic acid derivative 64 under Suzuki conditions, followed by deprotection to give 61. (Scheme 28) [ka] Scheme 28

[0248] Building blocks of formula 65, where L1 = bond and L2 = -NHCH2-, can be generated by reductive amination reaction of appropriately protected aldehyde 66 with amine 53 in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). Optionally, the reductive amination step can be carried out before the coupling of A and B, which can be carried out as described in Scheme 4 (Scheme 29). [ka] Scheme 29

[0249] Building blocks of formula 67, where L1 = bond and L2 = -NHCH2-, can be generated by Curtius rearrangement of appropriately protected acid building blocks 68 (e.g., using diphenylphosphonic acid azide, benzyl alcohol) and deprotection of the resulting carbamate (e.g., Pd / C, H2) to give amines 69, followed by further reductive amination of amines 69 with the appropriate aldehyde 70, followed by subsequent deprotection (Scheme 30). [ka] Scheme 30

[0250] Building blocks of formula 71, where L1 = bond, L2 = bond, and C = heteroaryl, can be prepared using standard heteroaryl synthesis techniques starting from building blocks 72 (X = CN, COOH) bearing cyano or carboxylic acid groups. Typical heterocyclic synthesis reactions can include, for example, the reaction of a carboxylic acid with a hydrazide to form a 1,3,4-oxadiazole derivative, the reaction of a cyano group with a hydrazide derivative to form a 1,2,4-triazole, or the cycloaddition of a cyano group with azidotrimethylsilane to form a tetrazole. (Scheme 31) [ka] Scheme 31

[0251] Alternatively, building blocks of formula 73 where L1 = -CH2NH- or -CH2NH- can be installed by reductive amination of amine 28 with an appropriately protected aldehyde building block 41 in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanoborohydride, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 32). [ka] Scheme 32

[0252] Alternatively, the component of formula 74 where A is a C bond and L = -SO2- can be prepared by the reaction of thiol 75 with (spiro)cyclic amine A (Y = leaving group, e.g., OMs) and S under basic conditions (e.g., K2CO3). N 2, followed by oxidation of the thioether to the sulfone (e.g., mCPBA) and deprotection under standard conditions (e.g., with TsOH when PG=Boc). (Scheme 33) The same sequence can be used to generate sulfoximes (L1=-SNO-) using a modified oxidation step (e.g., using iodobenzene diacetate and ammonium carbamate) to introduce sulfoximines from the thioether. [ka] Scheme 33

[0253] Alternatively, building blocks of Formula 76 where L1 = -SO2NH- can be prepared by reaction of sulfonyl chloride 33 and an appropriately protected (spiro)cyclic amine (44) in the presence of a base such as DIPEA, followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc) (Scheme 34). [ka] Scheme 34

[0254] Alternatively, building blocks of formula 77, where L1 and L2 = bond, B is (hetero)aryl, and C is an N-linked cyclic amine, can be prepared by reacting an appropriately protected (spiro)cyclic amine (Y = I or Br) in two sequential cross-coupling reactions, followed by deprotection. Most typically, this involves Ni-catalyzed cross-coupling between 10 (Y = I) and building block 62, which bears both bromide and boronic acid functionalities, to give bromo(hetero)aryl intermediate 63. Intermediate 63 is coupled with amine 78 (e.g., under Buchwald conditions, Pd catalysis), followed by deprotection, to give 77. (Scheme 35) [ka] Scheme 35

[0255] The component (79) where L1=bond, L2=O, and B=C-bonded (hetero)aryl and C=(hetero)aryl can be prepared by reacting (hetero)aryl alcohol 80 with dihalo(hetero)aryl 47 (X1, X2=halides, e.g., Br) in S NIt can be generated by Ar reaction (e.g., using K2CO3), followed by cross-coupling to introduce the A ring (e.g., photochemical cross-coupling using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2.DME, dtbbpy, and (TMS)3SiH), followed by deprotection (Scheme 36). [ka] Scheme 36

[0256] Alternatively, L1=bond, L2=O, and B=C-bonded (hetero)aryl or C3-C 10 The building blocks (79) where Y is -cycloalkyl and C=(hetero)aryl can be prepared by cross-coupling (spiro)cyclic amines 10 (Y=Br, I) with halophenol building blocks 82 (X1=Br, I) (e.g., photochemical cross-coupling using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2, DME, dtbbpy, and (TMS)3SiH), followed by S-coupling of phenols 83 with (hetero)aryl halides 84 (X2=F, Cl, Br) (e.g., using K2CO3). N A similar scheme can be used to prepare the compound S. N It is also suitable for introducing small (cyclo)aliphatic units onto the phenolic oxygen via the 2 reaction. In some cases, especially when B=C3-C 10 In the case of -cycloalkyl, intermediates of general formula 83 are commercially available and can be used directly in the aromatic substitution step. [ka] Scheme 37

[0257] L1 and L2 = bond, B = (hetero)aryl, and C = C3-C 10The -cycloalkyl, 3- to 14-membered heterocyclyl building blocks of formula 61 can be prepared by reacting appropriately protected (spiro)cyclic amines 10 (Y = I or Br) in two sequential cross-coupling reactions, followed by deprotection. Most typically, this involves a Negishi cross-coupling of the zincate transiently generated from 10 (Y = I) with building blocks 85 bearing two bromide functional groups, yielding bromo(hetero)aryl intermediates 63. Cross-coupling between intermediate 63 and bromide 86 in a photochemical reaction using Ir[dF(CF3)ppy]2(dtbbpy)PF6, NiCl2, DME, dtbbpy, and (TMS)3SiH, followed by deprotection, generates building blocks of general formula 61. (Scheme 38) [ka] Scheme 38

[0258] R 3 =H, and R 4 Building blocks of formula 3, where PG = halo-C1-C6-(cyclo)alkyl, can be generated by cyclization of nitrile 87 with carbohydrazide 88 in the presence of a base such as K2CO3 in a polar protic solvent such as n-BuOH to give intermediate 89. Building block 3 can be generated by deprotection of intermediate 89 (e.g., using TsOH or TFA where PG = Boc, or Pd(OH)2 / C catalyzed hydrogenation where PG = Cbz). (Scheme 39) If cyano building block 87 is not commercially available due to the required protecting group, it can be obtained by conversion of the alcohol to the mesylate (e.g., using MsCl, Et3N) and subsequent deprotection of the S with the cyano group. N It can be conveniently generated via 2-substitution (eg, using NaCN in DMF). [ka] Scheme 39

[0259] Alternatively, R 4=H, the building blocks of formula 3 could be generated by heating the appropriately protected amide in the presence of DMF-DMA, followed by heating in the presence of hydrazine and acetic acid to generate the 1,2,4-triazole, which could then be deprotected under standard conditions (e.g., using TsOH or TFA where PG = Boc).

[0260] Alternatively, R 3 =H, and R 4 = group-C(R 4a R 4b R 4c ) and R 4a is halo-C1-C6-(cyclo)alkyl, and R 4b is hydroxy and R 4c For building blocks of formula 3 where PG is hydrogen, nitrile building block 87 can be converted to the corresponding thioamide 90 using, for example, (NH)S and MgCl. Intermediate 90 can then be converted to carboximidothioate 91 using MeI in a solvent such as acetone or THF. Triazole 89 can be obtained after cyclization of intermediates 88 and 91 in the presence of a base such as KCO in a polar protic solvent such as n-BuOH. Building block 3 can be generated from intermediate 89 after a deprotection step (e.g., using TsOH or TFA where PG=Boc). (Scheme 40) [ka] Scheme 40

[0261] Alternatively, compounds of formula I in which the A ring is C-linked to the carbonyl can be generated by amide coupling of acid 92 with amine 3 under standard conditions, for example, using HATU and DIPEA in DMF (Scheme 41). [ka] Scheme 41

[0262] Alternatively, the acid component of general formula 93, where L1 = NH, A is a C bond, and B is a (hetero)aryl, can be prepared by the S reaction of (hetero)aryl halides 39 (X = F, Cl, Br, adjacent to the pyridyl nitrogen) with amines 94. N It can be prepared using Ar reaction (e.g., using DIPEA, DMF) followed by deprotection of the methyl ester to the carboxylic acid (e.g., using aqueous base, e.g., LiOH(aq)). (Scheme 42)

[0263] It can also be appreciated that in Schemes 3-38, 43-45, and 47-61, the N-PG on the A ring can also be a suitably protected carboxylic acid equivalent (e.g., CH(COOPG)), and the same synthetic sequence can be followed to further functionalize the A ring to generate additional acid building blocks 92. [ka] Scheme 42

[0264] Building blocks of formula 95, where L1 = bond and L2 = -NHCH2-, can be generated by Curtius rearrangement of an appropriately protected acid building block 96 (e.g., using diphenylphosphonic acid azide, benzyl alcohol) and deprotection of the resulting carbamate (e.g., Pd / C, H2) to give amine 97, followed by further reductive amination of amine 97 with an appropriate aldehyde 98, followed by subsequent deprotection. (Scheme 39) Alternatively, amine 97 can be used in heterocycle synthesis reactions to generate N-linked heterocyclic C-rings (e.g., condensation with an appropriate 1,3-dione, O-(4-nitrobenzoyl)hydroxylamine, to generate pyrazoles). [ka] Scheme 43

[0265] Alternatively, components of general formula 99, where L1 = bond, L2 = CH2, and B is C-bonded heteroaryl or C3-C10-(cyclo)alkyl, can be prepared by Mitsunobu-type reaction of heterocycle B (100) with hydroxyl component 101 (e.g., using diisopropyl azodicarboxylate and triphenylphosphine, or Tsunoda reagent (cyanomethylenetrimethylphosphorane)), followed by deprotection under standard conditions (e.g., with TsOH when PG = Boc). (Scheme 44) Alternatively, components of formula 99 can be prepared by converting hydroxyl component 101 to a mesylate (e.g., using MsCl, Et3N), followed by deprotection of heterocycle B (100) with S in the presence of a base such as NaH. N It can be prepared by reacting [ka] Scheme 44

[0266] Alternatively, components of formula 102 where B is a C-linked heteroaryl and L = -CH- can be prepared using standard heterocyclic synthesis techniques starting from the appropriate carboxylic acid or (104) or ester, nitrile (105) or diketone (106) derivatives. The nitrile derivatives can be prepared from the hydroxyl derivative (101) by conversion to the mesylate (e.g., with MsCl, EtN) followed by conversion of the mesylate group to S with cyanide. N The diketone derivative can be prepared from the commercially available ester derivative (103) by di-substitution (e.g., with KCN). (Scheme 45) [ka] Scheme 45

[0267] The (hetero)aryltrifluoromethylcyclopropyl building block 107 is not commonly available and was instead generated from the halide building block 108 ((X = I, Br)) by Suzuki reaction with 1-(trifluoromethyl)vinylboronic acid to give 109. Cyclopropanation with diphenyl(methyl)sulfonium tetrafluoroborate and LiHMDS afforded the required building block 107. (Scheme 46) This sequence can also be performed in other synthetic schemes, for example, between steps of the N-linked heteroaryl ring B; these functionalization steps can also be performed after the Suzuki / hydrogenation sequence but before final deprotection while preparing the building block of formula 4 (see Scheme 3). Alternatively, the (hetero)aryltrifluoromethylcyclopropyl building block can be generated from commerci...

Claims

1. Formula (I) 【Chemistry 1】 (In the formula, A is, 【Chemistry 2】 is selected from B is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L １ は, shared combination, カルボニル, -CR ８ａ R ８ｂ -, -CH ２ O-, -OCH ２ -, -CH ２ NR １３ａ - NR １３ｂ CH ２ -, -CH ２ CH ２ -, -CH ２ NR １３ｃ CH ２ -, -CH ２ NHCO-、-O-、-NH-、-SOO ２ NH-, -NHSO ２ -, -SO ２ NHCH ２ -, -CH ２ NH4SO ２ -, -SO ２ -, -CH ２ SO ２ -, -SO ２ CH ２ -, -NHC (O) -, -C (O) NH -, および 【Transformation 3】 is selected from L ２ is a covalent bond, -CR ８ａ R ８ｂ -, -NH-, -N(C １ -C ６ -alkyl)-, -O-, -CH ２ NH-, -NHCH ２ -, -CH ２ O-, -OCH ２ -, -SO ２ -, -CH ２ SO ２ -, and -SO ２ CH ２ - is selected from, X is NH or O; R １ is the base 【Chemistry 4】 C １ -C ６ -Alkyl-SO ２ -NH-, C １ -C ６ -Alkyl-SO ２ -, and halo-C １ -C ６ -alkyl-C(O)-; R ２ is selected from hydrogen and hydroxy; R ３ is hydrogen, halogen, cyano, C １ -C ６ Alkyl, C １ -C ６ selected from alkoxy and hydroxy; R ４ is hydrogen and a group —C(R ４ａ R ４ｂ R ４ｃ ) are selected from R ４ａ is C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R ４ｂ is selected from hydrogen and hydroxy; R ４Ｃ is hydrogen, or R ４ａ , R ４ｂ and R ４ｃ are each independently selected from hydrogen and halogen; R ４ａ and R ４ｂ together with the carbon atoms to which they are attached, form C ３ -C １０ -cycloalkyl or 3- to 14-membered heterocyclyl, R ４ｃ is selected from hydrogen, hydroxy, amino, and halogen, ３ -C １０ -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R ５ is hydrogen, hydroxy, halogen, cyano, C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, hydroxy-halo-C １ -C ６ -Alkyl, carboxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -alkoxy, oxo, NH ２ -SO ２ -, Amino, C １ -C ６ Alkyl-NH-, (C １ -C ６ -alkyl) ２ N-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, (C １ -C ６ -alkyl) ２ N—C(O)—, carboxy, C １ -C ６ -alkoxycarbonyl, C １ -C ６ -alkoxycarbonyl-C １ -C ６ -alkyl-, (C １ -C ６ -alkyl) ２ P(O)-, (C １ -C ６ -alkyl) ２ P(O)-C １ -C ６ -alkyl-, group 【Transformation 5】 and groups 【Transformation 6】 is selected from R ６ is hydrogen, halogen, cyano, oxo, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, halo-C １ -C ６ - alkyl, and C １ -C ６ -Alkyl-SO ２ - is selected from, R ７ is hydrogen and C １ -C ６ - alkyl, R ８ａ is hydrogen, halogen, C １ -C ６ - alkyl, and carbamoyl; R ８ｂ is selected from hydrogen and halogen; R ９ is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C １ -C ６ -alkoxycarbonyl, amino, C １ -C ６ -alkyl-NH-, (C １ -C ６ -alkyl) ２ N-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, C ３ -C １０ -cycloalkyl, cyano, C １ -C ６ -Alkyl-SO ２ -, Halo-C １ -C ６ -Alkyl-SO ２ -, and 5- to 14-membered heteroaryl, ３ -C １０ -Cycloalkyl and 5- to 14-membered heteroaryl are C １ -C ６ -Alkyl and halo-C １ -C ６ - optionally substituted with one substituent selected from alkyl, or R ９ and R ５ Together, we can 【Transformation 7】 Forming R １０ is hydrogen, halogen, C １ -C ６ -Alkyl, halo-C １ -C ６ - selected from alkyl and oxo, R １１ is selected from hydrogen and halogen; R １２ is amino, C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R １３ａ , R １３ｂ and R １３ｃ are each independently hydrogen, C １ -C ６ -Alkyl, C ３ -C １０ -cycloalkyl, C ３ -C １０ -cycloalkyl-C １ -C ６ -alkyl-) or a pharmaceutically acceptable salt thereof.

2. A is, 【Transformation 8】 2. The compound of formula (I) according to claim 1, selected from: or a pharmaceutically acceptable salt thereof.

3. A is, 【Chemistry 9】 3. The compound of formula (I) according to claim 2, selected from: or a pharmaceutically acceptable salt thereof.

4. B is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L １ が, shared combination, カルボニル, -CR ８ａ R ８ｂ -, -CH ２ O-, -OCH ２ -, -CH ２ NR １３ａ - NR １３ｂ CH ２ -, -CH ２ CH ２ -, -CH ２ NR １３ｃ CH ２ -, -CH ２ NHCO-、-O-、-NH-、-SOO ２ NH-, -NHSO ２ -, -SO ２ NHCH ２ -, -CH ２ NH4SO ２ -, -SO ２ -, -NHC (O) -, -C (O) NH -, および 【Chemistry 10】 is selected from L ２ is a covalent bond, -CR ８ａ R ８ｂ -, -NH-, -N(C １ -C ６ -alkyl)-, -O-, -CH ２ NH-, -NHCH ２ -, -CH ２ O-, -OCH ２ -, -SO ２ - and -CH ２ SO ２ - is selected from, X is NH or O, R １ But, 【Chemistry 11】 C １ -C ６ -Alkyl-SO ２ -NH-, C １ -C ６ -Alkyl-SO ２ -, and halo-C １ -C ６ -alkyl-C(O)-; R ２ is selected from hydrogen and hydroxy; R ５ is hydrogen, hydroxy, halogen, cyano, C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, hydroxy-halo-C １ -C ６ -Alkyl, carboxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -alkoxy, oxo, NH ２ -SO ２ -, C １ -C ６ -Alkyl-NH-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, carboxy, C １ -C ６ -alkoxycarbonyl, C １ -C ６ -alkoxycarbonyl-C １ -C ６ -alkyl-, (C １ -C ６ -alkyl) ２ P(O)-, (C １ -C ６ -alkyl) ２ P(O)-C １ -C ６ -alkyl-, group 【Chemistry 12】 and groups 【Chemistry 13】 is selected from R ６ is hydrogen, halogen, cyano, oxo, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, halo-C １ -C ６ - alkyl, and C １ -C ６ -Alkyl-SO ２ - is selected from, R ７ is hydrogen and C １ -C ６ - alkyl, R ８ａ But hydrogen, halogen, C １ -C ６ - alkyl, and carbamoyl; R ８ｂ is selected from hydrogen and halogen; R ９ is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C １ -C ６ -alkoxycarbonyl, C １ -C ６ -Alkyl-NH-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, C ３ -C １０ -cycloalkyl, cyano, C １ -C ６ -Alkyl-SO ２ -, Halo-C １ -C ６ -Alkyl-SO ２ -, and 5- to 14-membered heteroaryl, ３ -C １０ -Cycloalkyl and 5- to 14-membered heteroaryl are C １ -C ６ -Alkyl and halo-C １ -C ６ - optionally substituted with one substituent selected from alkyl, or R ９ and R ５ Together, we can 【Chemistry 14】 Forming R １０ But hydrogen, halogen, C １ -C ６ -Alkyl, halo-C １ -C ６ - selected from alkyl and oxo, R １１ is selected from hydrogen and halogen; R １２ But Amino, C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R １３ａ But hydrogen, C １ -C ６ -Alkyl, C ３ -C １０ -cycloalkyl, C ３ -C １０ -cycloalkyl-C １ -C ６ -alkyl-, R １３ｂ is hydrogen, R １３ｃ is hydrogen and C １ -C ６ 4. The compound of formula (I) according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, wherein: - alkyl is selected from:

5. B is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C ３ -C １０ - selected from cycloalkyl and 5- to 14-membered heteroaryl; L １ is a covalent bond, -CR ８ａ R ８ｂ - and -CH ２ O-, L ２ is a covalent bond, -NH-, and -CH ２ NH-; X is NH or O, R １ Based on 【Chemistry 15】 and R ２ is hydrogen, R ５ But halogen, cyano, halo-C １ -C ６ -Alkyl, oxo, halo-C １ -C ６ -alkoxy, C １ -C ６ -Alkyl-SO ２ -, Halo-C １ -C ６ -Alkyl-SO ２ -, group 【Chemistry 16】 and groups 【Chemistry 17】 is selected from R ６ is hydrogen, halogen, cyano and halo-C １ -C ６ - alkyl, R ７ is hydrogen and C １ -C ６ - alkyl, R ８ａ is selected from hydrogen and halogen; R ８ｂ is selected from hydrogen and halogen; R ９ But hydrogen, C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R １０ But hydrogen, C １ -C ６ -alkyl, and halo-C １ -C ６ - alkyl, R １１ is hydrogen, R １２ But, Halo-C １ -C ６ 5. The compound of formula (I) according to claim 4, or a pharmaceutically acceptable salt thereof, wherein R is - alkyl.

6. B is selected from phenyl, bicyclo[1.1.1]pentyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-dihydropyridyl, and 1,2-dihydropyrazinyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazolyl, 1,3,4-thiadiazolyl, and pyrazinyl; L １ is a covalent bond, -CR ８ａ R ８ｂ - and -CH ２ O-, L ２ is a covalent bond, -NH-, -CH ２ NH-; X is NH or O, R １ Based on [Chemistry 18] and R ２ is hydrogen, R ５ However, chloro, fluoro, cyano, CF ３ , 2,2,2-trifluoroethyl, CF ３ O, oxo, methylsulfonyl, CF ３ -SO ２ -, group 【Chemistry 19】 and groups 【Chemistry 20】 is selected from R ６ is hydrogen, fluoro, cyano and CF ３ is selected from R ７ is selected from hydrogen and methyl; R ８ａ is selected from hydrogen and fluoro; R ８ｂ is selected from hydrogen and fluoro; R ９ is hydrogen, methyl, 2,2-dimethylpropyl, CHF ２ and C.F. ３ is selected from R １０ is hydrogen, methyl and CF ３ is selected from R １１ is hydrogen, R １２ is CF ３ 6. The compound of formula (I) according to claim 5, wherein:

7. R ３ The compound of formula (I) according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, wherein is hydrogen.

8. R ４ is a group -C(R ４ａ R ４ｂ R ４ｃ ) and R ４ａ , R ４ｂ , and R ４ｃ are each independently a halogen, or R ４ａ and R ４ｂ together with the carbon atoms to which they are attached, C ３ -C １０ - forms a cycloalkyl, R ４ｃ is selected from hydrogen, hydroxy, and halogen, and said C ３ -C １０ 4. A compound of formula (I) according to any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, wherein -cycloalkyl is optionally substituted with 1 to 2 halogen substituents.

9. R ４ is a group -C(R ４ａ R ４ｂ R ４ｃ ) and R ４ａ , R ４ｂ , and R ４ｃ are each independently fluoro, or R ４ａ and R ４ｂ together with the carbon atom to which they are attached form cyclopropyl or cyclobutyl, R ４ｃ 9. The compound of formula (I) according to claim 8, or a pharmaceutically acceptable salt thereof, wherein is selected from hydrogen, hydroxy, and fluoro, and said cyclopropyl is substituted with 1 to 2 fluoro substituents.

10. A is, 【Chemistry 21】 is selected from B is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl; L １ が, shared combination, カルボニル, -CR ８ａ R ８ｂ -, -CH ２ O-, -OCH ２ -, -CH ２ NR １３ａ - NR １３ｂ CH ２ -, -CH ２ CH ２ -, -CH ２ NR １３ｃ CH ２ -, -CH ２ NHCO-、-O-、-NH-、-SOO ２ NH-, -NHSO ２ -, -SO ２ NHCH ２ -, -CH ２ NH4SO ２ -, -SO ２ -, -NHC (O) -, -C (O) NH -, および 【Chemistry 22】 is selected from L ２ is a covalent bond, -CR ８ａ R ８ｂ -, -NH-, -N(C １ -C ６ -alkyl)-, -O-, -CH ２ NH-, -NHCH ２ -, -CH ２ O-, -OCH ２ -, -SO ２ - and -CH ２ SO ２ - is selected from, X is NH or O, R １ But, 【Chemistry 23】 C １ -C ６ -Alkyl-SO ２ -NH-, C １ -C ６ -Alkyl-SO ２ -, and halo-C １ -C ６ -alkyl-C(O)-; R ２ is selected from hydrogen and hydroxy; R ３ is hydrogen, R ４ is hydrogen, and the group —C(R ４ａ R ４ｂ R ４ｃ ) are selected from R ４ａ Halo-C １ -C ６ -alkyl, and R ４ｂ is hydroxy, and R ４ｃ is hydrogen, or R ４ａ , R ４ｂ , and R ４ｃ are each independently a halogen, or R ４ａ and R ４ｂ together with the carbon atoms to which they are attached, form C ３ -C １０ -cycloalkyl or 3- to 14-membered heterocyclyl, R ４ｃ is selected from hydrogen, hydroxy, amino, and halogen, ３ -C １０ -cycloalkyl and 3- to 14-membered heterocyclyl are optionally substituted by 1 to 2 halogen substituents; R ５ is hydrogen, hydroxy, halogen, cyano, C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, hydroxy-halo-C １ -C ６ -Alkyl, carboxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -alkoxy, oxo, NH ２ -SO ２ -, C １ -C ６ -Alkyl-NH-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, carboxy, C １ -C ６ -alkoxycarbonyl, C １ -C ６ -alkoxycarbonyl-C １ -C ６ -alkyl-, (C １ -C ６ -alkyl) ２ P(O)-, (C １ -C ６ -alkyl) ２ P(O)-C １ -C ６ -alkyl-, group 【Chemistry 24】 and groups 【Chemistry 25】 is selected from R ６ is hydrogen, halogen, cyano, oxo, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, halo-C １ -C ６ - alkyl, and C １ -C ６ -Alkyl-SO ２ - is selected from, R ７ is hydrogen and C １ -C ６ - alkyl, R ８ａ But hydrogen, halogen, C １ -C ６ - alkyl, and carbamoyl; R ８ｂ is selected from hydrogen and halogen; R ９ is hydrogen, halogen, cyano, hydroxy, oxo, carboxy, C １ -C ６ -alkoxycarbonyl, C １ -C ６ -Alkyl-NH-, carbamoyl, C １ -C ６ -alkyl-NH-C(O)-, C １ -C ６ -Alkyl, hydroxy-C １ -C ６ -Alkyl, halo-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy-C １ -C ６ -Alkyl, C １ -C ６ -alkoxy, halo-C １ -C ６ -alkoxy, C ３ -C １０ -cycloalkyl, cyano, C １ -C ６ -Alkyl-SO ２ -, Halo-C １ -C ６ -Alkyl-SO ２ -, and 5- to 14-membered heteroaryl, ３ -C １０ -Cycloalkyl and 5- to 14-membered heteroaryl are C １ -C ６ -Alkyl and halo-C １ -C ６ - optionally substituted with one substituent selected from alkyl, or R ９ and R ５ But together, 【Chemistry 26】 Forming R １０ But hydrogen, halogen, C １ -C ６ -Alkyl, halo-C １ -C ６ - selected from alkyl and oxo, R １１ is selected from hydrogen and halogen; R １２ But Amino, C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R １３ａ But hydrogen, C １ -C ６ -Alkyl, C ３ -C １０ -cycloalkyl, C ３ -C １０ -cycloalkyl-C １ -C ６ -alkyl-, R １３ｂ is hydrogen, R １３ｃ is hydrogen and C １ -C ６ 2. The compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R is selected from -alkyl.

11. A is, 【Chemistry 27】 is selected from B is C ６ -C １４ -aryl, C ３ -C １０ - selected from cycloalkyl, 5- to 14-membered heteroaryl, and 3- to 14-membered heterocyclyl; C is C ３ -C １０ - selected from cycloalkyl and 5- to 14-membered heteroaryl; L １ is a covalent bond, -CR ８ａ R ８ｂ - and -CH ２ O-, L ２ is a covalent bond, -NH-, -CH ２ NH-; X is NH or O, R １ Based on 【Chemistry 28】 and R ２ is hydrogen, R ３ is hydrogen, R ４ is a group -C(R ４ａ R ４ｂ R ４ｃ ) and R ４ａ , R ４ｂ , and R ４ｃ are each independently a halogen, or R ４ａ and R ４ｂ together with the carbon atoms to which they are attached, C ３ -C １０ - forms a cycloalkyl, R ４ｃ is selected from hydrogen, hydroxy, and halogen, and said C ３ -C １０ -cycloalkyl optionally substituted with 1 to 2 halogen substituents; R ５ But halogen, cyano, halo-C １ -C ６ -Alkyl, halo-C １ -C ６ -alkoxy, C １ -C ６ -Alkyl-SO ２ -, Halo-C １ -C ６ -Alkyl-SO ２ -, oxo, group 【Chemistry 29】 and groups 【Transformation 30】 is selected from R ６ is hydrogen, halogen, cyano and halo-C １ -C ６ - alkyl, R ７ is hydrogen and C １ -C ６ - alkyl, R ８ａ is selected from hydrogen and halogen; R ８ｂ is selected from hydrogen and halogen; R ９ But hydrogen, C １ -C ６ -Alkyl and halo-C １ -C ６ - alkyl, R １０ But hydrogen, C １ -C ６ -alkyl, and halo-C １ -C ６ - alkyl, R １１ is hydrogen, R １２ Halo-C １ -C ６ 11. The compound of formula (I) according to claim 10, or a pharmaceutically acceptable salt thereof, wherein: R is alkyl;

12. A is, 【Chemistry 31】 is selected from B is selected from phenyl, bicyclo[1.1.1]pentanyl, pyridyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,4-thiadiazolyl, pyrazolyl, imidazolyl, 1H-1,2,4-triazolyl, triazol-2-yl, 2H-triazolyl, isoxazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-dihydropyridyl, and 1,2-dihydropyrazinyl; C is selected from cyclopropyl, pyrazolyl, 1,3,4-oxadiazole, pyrazinyl, and 1,3,4-thiadiazolyl; L １ is a covalent bond, -CR ８ａ R ８ｂ - and -CH ２ O-, L ２ is a covalent bond, -NH-, -CH ２ NH-; X is NH or O, R １ Based on 【Chemistry 32】 and R ２ is hydrogen, R ３ is hydrogen, R ４ is a group -C(R ４ａ R ４ｂ R ４ｃ ) and R ４ａ , R ４ｂ , and R ４ｃ are each independently fluoro, or R ４ａ and R ４ｂ together with the carbon atom to which they are attached form a cyclopropyl, and R ４ｃ is selected from hydrogen, hydroxy, and fluoro, said cyclopropyl being optionally substituted with 1 to 2 fluoro substituents; R ５ However, chloro, fluoro, cyano, CF ３ , 2,2,2-trifluoroethyl, CF ３ O, methylsulfonyl, CF ３ -SO ２ -, oxo, group 【Transformation 33】 and groups 【Transformation 34】 is selected from R ６ is hydrogen, fluoro, cyano and CF ３ is selected from R ７ is selected from hydrogen and methyl; R ８ａ is selected from hydrogen and fluoro; R ８ｂ is selected from hydrogen and fluoro; R ９ is hydrogen, methyl, 2,2-dimethylpropyl, CHF ２ and C.F. ３ is selected from R １０ is hydrogen, methyl and CF ３ is selected from R １１ is hydrogen, R １２ is CF ３ 12. The compound of formula (I) according to claim 11, wherein:

13. 2. A compound of formula (I) according to claim 1 selected from the following or a pharmaceutically acceptable salt thereof: [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-fluoro-5-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-fluoro-5-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-fluoro-2-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-fluoro-2-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(2,4-difluorophenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methylsulfonyl-4-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(4-methyl-4-oxo-1,4λ ５ -azaphosphinan-1-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-3-(trifluoromethyl)benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]amino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[1-(trifluoromethyl)cyclopropyl]-2-azaspiro[3.3]heptane-6-carboxamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[2-(trifluoromethyl)pyrimidin-4-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyridazin-3-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(1,1-dioxothiolan-3-yl)amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(3-hydroxy-3-methyl-azetidin-1-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)azetidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethylsulfonyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonyl)phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethoxy)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-fluoro-2-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[3-fluoro-5-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[2-[4-(trifluoromethyl)phenyl]sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2,4-difluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(3,4-difluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [2-(2-chloro-4-fluorophenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2-methoxyphenyl)sulfonyl-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[5-(trifluoromethyl)-3-pyridyl]sulfonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-methylsulfonyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-methylsulfonyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(methylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(methylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (rac)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (S)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (R)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (R)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; (S)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-fluoro-4-methylsulfonyl-phenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)pyrazin-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[5-(trifluoromethyl)pyrimidin-2-yl]oxy-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-(5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [7-[(5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[[6-(difluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6R)-6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6R)-6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methylsulfonyl-3-(trifluoromethyl)phenyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; 5-[[rac-(6S)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]oxy]-2-(trifluoromethyl)pyridine-4-carbonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[rac-(6S)-6-[4-methylsulfonyl-3-(trifluoromethyl)phenoxy]-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluorophenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3,5-difluoro-2-pyridyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylsulfonylphenyl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzenesulfonamide; Methyl 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzoate; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]benzoic acid; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-N-methyl-benzamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-[1-(methoxymethyl)-1,2,4-triazol-3-yl]phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-[1-(methoxymethyl)imidazol-2-yl]phenyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(4-methylsulfonylphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethylsulfonyl)phenyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[(3-methylsulfonylphenyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-fluoro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-chloro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethoxy)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-chloro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethoxy)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[3-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[3-chloro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-fluoro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[5-chloro-2-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[cyclopropyl-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]amino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[cyclopropylmethyl-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]amino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-3-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-2-fluoro-4-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-4,4-difluoro-cyclohexanesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-3-(trifluoromethoxy)benzenesulfonamide; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methylamino]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoroethoxy)pyrazol-1-yl]azetidin-1-yl]methanone; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-3-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]methyl]-3-(trifluoromethyl)benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-(2,2-dimethylpropylsulfonyl)-2,6-diazaspiro[3.3]heptan-6-yl]methanone; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-(1-methylcyclopropyl)-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[(4-fluorophenyl)methyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[1-(trifluoromethyl)cyclopropyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 6-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[[1-(trifluoromethyl)cyclopropyl]methyl]-2,6-diazaspiro[3.3]heptane-2-sulfonamide; 1-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]-2,2,2-trifluoroethanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrazin-2-yl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4,4-difluoro-1-piperidyl)methyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1,1-dioxo-1,4-thiazinan-4-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-1-(trifluoromethyl)cyclopropanecarboxamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-4-(trifluoromethyl)benzenesulfonamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-2-(trifluoromethyl)benzenesulfonamide; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]-2,2-dimethyl-propane-1-sulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-(2,2,2-trifluoro-1-hydroxy-ethyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-[(1R)-2,2,2-trifluoro-1-hydroxy-ethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[5-[(1S)-2,2,2-trifluoro-1-hydroxy-ethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[1-(trifluoromethyl)cyclopropyl]pyridazin-3-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[1-(trifluoromethyl)cyclopropyl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]sulfonyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[2-fluoro-4-(trifluoromethyl)phenyl]sulfonyl-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-fluoro-4-(trifluoromethoxy)phenyl]azetidin-1-yl]methanone; [3-[3-fluoro-4-(trifluoromethoxy)phenyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonyl)phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoroethyl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methyl]-1,2,4-oxadiazol-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-3-yl]azetidin-1-yl]methanone; [3-(2-chloro-4-isopropylsulfonyl-phenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-4-(trifluoromethyl)benzenesulfonamide; N-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-4-fluorobenzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]-4-(trifluoromethyl)benzenesulfonamide; N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]-4-(trifluoromethoxy)benzenesulfonamide; 4-chloro-N-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methyl]benzenesulfonamide; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]methylamino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methylamino]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methylamino]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]methylamino]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3R)-3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3S)-3-(trifluoromethyl)pyrrolidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(3S)-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[(3R)-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[rac-(3R)-3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[rac-(3S)-3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclobutyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[[1-(trifluoromethyl)cyclopropyl]amino]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]amino]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-diisopropylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [3-[4-(3-tert-butyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; (4R) or (4S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)piperidin-2-one; (4S) or (4R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)piperidin-2-one; [7-(5-chloro-3-fluoro-2-pyridyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(4-chloro-2-fluoro-phenyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4-(trifluoromethyl)pyridin-2-one; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-(5-spiro[3.3]heptan-2-ylpyrazin-2-yl)azetidin-1-yl]methanone; [3-[4-(5-cyclopropyl-3-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-cyclopropyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2,2-difluoro-5-azaspiro[2.4]heptan-5-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(6-oxa-2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-hydroxy-3-(trifluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[3-(trifluoromethyl)azetidin-1-yl]-2-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(5-oxa-2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-dimethylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(hydroxymethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2-oxaspiro[3.3]heptan-6-yl)-3-pyridyl]azetidin-1-yl]methanone; 4-methylbenzenesulfonic acid; [3-(4-cyclobutyl-3-methylsulfonyl-phenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(1-hydroxy-1-methyl-ethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2,2-dimethylpropyl)-3-pyridyl]azetidin-1-yl]methanone; (trans)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(trifluoromethyl)cyclobutyl]-3-pyridyl]azetidin-1-yl]methanone; (trans)-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-(difluoromethyl)cyclobutyl]-3-pyridyl]azetidin-1-yl]methanone; [3-[6-(2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(2-oxa-7-azaspiro[3.4]octan-7-yl)-3-pyridyl]azetidin-1-yl]methanone; trans-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; cis-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)cyclobutyl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-hydroxy-3-[4-[3-(trifluoromethyl)azetidin-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-methoxy-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; 2-cyclopropyl-6-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxy-benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]methanone; [3-(4-cyclopropylphenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-(4-cyclopropyl-2-fluoro-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(trifluoromethyl)pyridazin-3-yl]oxyazetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethoxy)phenyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[4-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; 5-cyclopropyl-2-[1-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxy-benzonitrile; Methyl 2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxyphenyl]-2-methyl-propanoate; [3-[3-cyclopropyl-4-(trifluoromethyl)phenoxy]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(2-chloro-4-fluoro-phenyl)methoxy]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[3-(trifluoromethylsulfonyl)phenyl]methoxy]azetidin-1-yl]methanone; [3-(3-cyclopropyl-2-fluoro-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethyl)phenoxy]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-(4-chloro-3-cyclopropyl-phenoxy)azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4,4-difluorocyclohexyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(6,6-difluoro-3-bicyclo[3.1.0]hexanyl)methoxy]azetidin-1-yl]methanone; [3-[(6-chloro-5-cyclopropyl-3-pyridyl)oxy]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-(trifluoromethyl)-3-pyridyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(2-fluoro-4-methylsulfonyl-phenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[1-(trifluoromethyl)cyclopropyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[6-(trifluoromethyl)-3-pyridyl]methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(4-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(3-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(2-methylsulfonylphenyl)methoxy]azetidin-1-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-(2,2,2-trifluoro-1-hydroxyethyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-chloro-2-methylsulfonyl-phenyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [[3-[4-(2-chloro-4-methylsulfonyl-phenyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; Methyl 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzoate; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2,2-trifluoroethyl)-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [3-[3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(2,5-dichlorophenoxy)-2-azaspiro[3.5]nonan-2-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[2-fluoro-4-(trifluoromethyl)phenoxy]methyl]azetidin-1-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.5]nonan-7-yl]-3-(trifluoromethoxy)benzenesulfonamide; [3-[2-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [7-(5-chloro-2-methylsulfonyl-phenoxy)-2-azaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]methylamino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(2-chloro-4-fluoro-phenoxy)methyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(4-fluoro-2-methylsulfonyl-phenoxy)-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(2-chloro-4-fluorophenyl)sulfonyl-2-azaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[(3-methyl-1,1-dioxo-thietan-3-yl)amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; N-[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.5]nonan-7-yl]-4,4-difluoro-cyclohexanesulfonamide; 2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-N-[[1-(trifluoromethyl)cyclopropyl]methyl]-2-azaspiro[3.3]heptane-6-carboxamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[1-[[4-(trifluoromethyl)phenyl]methyl]azetidin-3-yl]azetidin-1-yl]methanone; [3-[(4-chlorophenyl)methyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]-2-(4-fluorophenyl)acetamide; [(3aR,6aS)-2-benzyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[(1,1-dioxothietan-3-yl)amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-[1-(2-tert-butyltetrazol-5-yl)cyclopropyl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)phenyl]azetidin-1-yl]methanone; [3-[6-(2-chlorophenoxy)-3-pyridyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(2,2-dimethylpropyl)triazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-(trifluoromethyl)pyrazin-2-yl]oxyphenyl]azetidin-1-yl]methanone; [3-[4-(benzenesulfonyl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; Methyl 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxylate; [3-(4-cyclohexylsulfonylphenyl)azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[6-(2-chlorophenoxy)-3-pyridyl]azetidin-1-yl]-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[[1-(trifluoromethyl)cyclopropyl]methoxy]phenyl]azetidin-1-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-[1-(trifluoromethyl)cyclopropyl]-4H-1,2,4-triazol-3-yl]phenyl]azetidin-1-yl]methanone; [3-[6-(2-chlorophenoxy)pyridazin-3-yl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(1H-tetrazol-5-yl)cyclopropyl]phenyl]azetidin-1-yl]methanone; 4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]benzenesulfonamide; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(dimethylphosphorylmethyl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(4-isopropyl-N-methyl-anilino)-3-pyridyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[6-(N-methylanilino)-3-pyridyl]azetidin-1-yl]methanone; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]piperidine-2-carboxamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4,4-difluoro-piperidine-2-carboxamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; 2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]oxyphenyl]-2-methyl-propanoic acid; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[2-fluoro-4-(trifluoromethyl)phenyl]methoxy]azetidin-1-yl]-[6-[5-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]benzoic acid; 2-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-N-ethyl-benzamide; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxylic acid; 1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]cyclopropanecarboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]piperidine-2-carboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4,4-difluoro-piperidine-2-carboxamide; (2R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-4,4-difluoro-piperidine-2-carboxamide; (2S)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; (2R)-1-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]pyrrolidine-2-carboxamide; [3-(6-tert-butyl-3-pyridyl)azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; Bis[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-ylidene]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylphenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-benzyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(2-tert-butylthiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-(2-hydroxy-2-methylpropyl)indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-triflylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[3-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethyl)thiazol-2-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-(2,2,2 trifluoroethyl)-2-pyridone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethyl)phenyl]sulfonimidoyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methoxy]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isothiazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-fluoro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[3-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[3-(5-neopentyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[[1-(trifluoromethyl); Cyclopropyl]amino]methyl]pyrazin-2-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[difluoro-[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(5-ethoxy-3-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-thiadiazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(2-fluoro-4-triflyl-benzyl)-2,6-diazaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-chloro-2-mesyl-phenyl)phenyl]azetidin-1-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)phenyl]sulfonimidoyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[3-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-dimethylphosphoryl-2-fluoro-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]-5-fluoro-benzonitrile; 3-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]; pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl)cyclopropyl]methoxy]pyrazin-2-yl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[1-(trifluoromethyl)cyclopropyl]-2-pyridyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-1-bicyclo[1.1.1]pentanyl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl-sulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(8S)-8-methyl-8-oxo-8λ6-thia-9-azatricyclo[8.4.0.02,7]tetradeca-1(10),2(7),3,5,8,11,13-heptaen-12-yl]azetidin-1-yl]methanone; 2-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[(8R)-8-methyl-8-oxo-8λ6-thia-9-azatricyclo[8.4.0.02,7]tetradeca-1(10),2(7),3,5,8,11,13-heptaen-12-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-6-keto-nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-(methylsulfonimidoyl)-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[(4-tert-butyloxazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethoxy)phenyl]sulfonyl-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-fluoro-benzonitrile; [6-[(5-tert-butyl-1,3,4-thiadiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-cyclopropylthiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(cyclopropylsulfonimidoyl); Phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(5-fluoro-3-pyridyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[3-(5-neopentyl-1,3,4-oxadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]piperidino]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]oxy]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(4-mesylpyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl); Cyclopropyl]methylamino]pyrazin-2-yl]azetidin-1-yl)methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(4-cyclopropylsulfonylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(difluoromethyl)thiazol-2-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-fluoro-2-[3-[1-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]benzonitrile; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-keto-nicotinonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3-cyclopropyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2-mesylphenyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[1-(2-hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-1H-imidazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[2-fluoro-4-(trifluoromethyl); phenyl]methyl]-1-bicyclo[1.1.1]; pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]; methylsulfonyl]-1-bicyclo[1.1.1]; pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[3-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethoxy)phenyl]sulfonyl-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-methyl-imidazole-4-carbonitrile; [2-(4-chloro-2-mesyl-phenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-triflylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1-methylpyrazol-4-yl)oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)tetrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[4-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethoxy)phenyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(trifluoromethyl)pyrazin-2-yl]oxy-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-ethyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(2-fluoro-4-triflyl-benzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 2-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-ethoxy-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(4-chloro-2-mesyl-phenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[6-(trifluoromethyl)-3-pyridyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-1-(2,2,2-trifluoroethyl)-2-pyridone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethoxy)phenyl]sulfonimidoyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[2-fluoro-4-(trifluoromethyl-sulfonimidoyl)benzyl]oxyazetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-phenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)-cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 3-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-methyl-pyrazole-3-sulfonamide; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(2,4-difluorobenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-cyclopropyl-3-methyl-pyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-cyclopropyl-3-methyl-pyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[(4-tert-butylisoxazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-methyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2-difluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[5-(methylamino)-1,3,4-thiadiazol-2-yl]phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]oxy]-2-(trifluoromethyl)benzonitrile; 5-[[2-[6-[5-(1-hydroxycyclopropyl)-4H-1,2,4-triazol-3-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-cyclobutylthiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[(6S)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclobutyl-1H-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(difluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-[(3-chloro-5-fluoro-2-pyridyl)oxy]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-2-methyl-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-([1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-(trifluoromethyl)pyrimidin-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]oxy-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]oxyazetidin-1-yl]methanone; [6-[2-mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-1,2,4-thiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)oxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-([1,2,4]triazolo[1,5-a]pyridin-6-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[6-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]-3-pyridyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-hydroxy-1,2,4-triazol-1-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(difluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(4-tert-butyl-1H-imidazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(methylsulfonimidoyl)-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-fluoro-5-(trifluoromethyl)-2-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3R)-3-(trifluoromethyl)pyrrolizino]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(4-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[(6R)-2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-mesyl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(4-fluorophenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)isothiazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-fluoro-5-(trifluoromethyl)-2-pyridyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-dimethylphosphoryl-5-fluoro-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)-2-pyridyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazolo[4,3-b]pyridin-5-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-fluoro-2-mesyl-phenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone [6-[(3-cyclopropyl-5-methyl-isoxazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(2,2,2-trifluoroethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazolo[4,3-b]pyridin-5-ylmethyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)oxazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[5-(trifluoromethyl)pyrimidin-2-yl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(2,2,2-trifluoroethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-[[(6S)-2-[6-[3-(1-hydroxy-cyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.4]octan-6-yl]oxy]-2-(trifluoromethyl)isonicotinonitrile; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]-amino]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)oxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3-cyclopropyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(4-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-fluoro-5-methoxyphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro-[3.3]heptan-2-yl]-[4-[3-[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo-[1.1.1]pentanyl]piperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(trifluoromethyl)pyrazin-2-yl]oxy-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[(3S)-3-(trifluoromethyl)pyrrolizino]pyrimidin-5-yl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)imidazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-(3,5-dimethylpyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isothiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-(4-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-2-pyridone; 1-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethoxy)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[4-(trifluoromethyl)phenyl]sulfonyl-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[4-(trifluoromethyl)phenyl]sulfonyl-2-azaspiro[3.5]nonan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(difluoromethoxy)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3,5-dimethylpyrazol-1-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6S)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)phenoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[[3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-fluoro-2-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[(5-chloro-3-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethylsulfonimidoyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(4-tert-butylthiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[(6R)-6-(3-triflylbenzyl)-2-azaspiro[3.4]octan-2-yl]methanone; [6-[3-fluoro-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(1,1-difluoroethyl)-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(cyclopropylsulfonimidoyl)phenyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1,2,4-triazol-1-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro-[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3,5-diisopropylpyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-fluoro-4-[[2-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]benzonitrile; [6-[3-mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[4-fluoro-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [7-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.5]nonan-2-yl]-[6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethoxy)-2-pyridone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 3-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(5-fluoro-3-pyridyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-ethyl-1,2,4-thiadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)oxazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-4-(trifluoromethyl)pyridin-2-one; 5-chloro-2-[3-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]-N-ethyl-benzamide; [6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethoxy)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-fluoro-benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-fluorophenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-mesylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-6-(trifluoromethyl)picolinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2-mesylphenyl)phenyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)phenyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)thiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)thiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(4-methylsulfonylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-chloro-5-fluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-mesylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[5-[[1-(trifluoromethyl); Cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1H-imidazol-4-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 3-fluoro-4-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[difluoro-[4-(trifluoromethyl)-phenyl]methyl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-pyrazol-3-ylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[3-(5-neopentyl-1,3,4-thiadiazol-2-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]pyrazole-4-carbonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(2,5-dimethylthiazol-4-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-mesyl-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)-3-pyridyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(4-methylimidazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]-sulfonyl]-1-bicyclo[1.1.1]pentanyl]-azetidin-1-yl]methanone; 5-[[2-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-mesyl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[5-(trifluoromethyl)pyrazin-2-yl]amino]cuban-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-neopentyltriazol-4-yl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.5]nonan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(4-mesylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-tert-butyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(3-cyclopropyl-5-methyl-pyrazol-1-yl)phenyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[1-(trifluoromethyl)cyclopropyl]methylamino]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[2-mesyl-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; 6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-N-[[6-(trifluoromethyl)-3,4-diazatricyclo[7.1.1.03,7]undeca-4,6-dien-1-yl]methyl]-2-azaspiro[3.3]heptane-2-carboxamide; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[6-(trifluoromethyl)-3-pyridyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[4-(4-cyclopropylimidazol-1-yl)phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]phenyl]azetidin-1-yl]methanone; [6-(2,4-difluorobenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(oxetan-3-yl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[2-[[3-methyl-5-(trifluoromethyl)-2-pyridyl]oxy]-7-azaspiro[3.5]nonan-7-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-dimethylphosphoryl-2-methyl-pyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-[5-cyclopropyl-3-(difluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[4-(1-hydroxyethyl)-5-methyl-thiazol-2-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3,5-dimethyl-1,2,4-triazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[6-(trifluoromethyl)-3-pyridyl]methyl]piperazino]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[fluoro-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-3-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-5-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethylsulfonimidoyl)phenoxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl]azetidin-1-yl]methanone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; 3-[[2-[6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-3-(trifluoromethyl)pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethoxy)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2-hydroxyethyl)-3-(trifluoromethyl)pyrrolo[2,3-b]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(4-cyclopropylsulfonylbenzyl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-3-methoxy-benzonitrile; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1,3,4-oxadiazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-dimethylphosphoryl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-[(2S)-3,3,3 trifluoro-2-hydroxy-propyl]indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[5-chloro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-propyl]indazol-3-yl]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[6-(trifluoromethyl)-3-pyridyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)benzonitrile; [7-(4-chloro-2-mesyl-phenyl)-2,7-diazaspiro[3.5]nonan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(4-ethylphenyl)methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-[5-(2-pyridyl)-2-thienyl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-[4-(methylamino)phenyl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(4-methyl-2-thienyl)methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[4-[3-cyclopropyl-5-(difluoromethyl)pyrazol-1-yl]phenyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[5-(trifluoromethyl)-2-pyridyl]methyl]piperazino]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-dimethylthiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[(2-methyloxazol-4-yl)methyl]piperazino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[(4-methylthiazol-5-yl)methyl]piperazino]methanone; [4-[(5-chloro-1,3-dimethyl-pyrazol-4-yl)methyl]piperazino]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2,6-diazaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(difluoromethyl)-3-methyl-pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[3-dimethylphosphoryl-5-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-3-methoxy-benzamide; [6-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(pyrazolo[1,5-a]pyridin-3-ylmethyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-mesyl-4-(trifluoromethyl)benzyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-dimethylphosphoryl-2-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[(4-chloro-2-methoxy-benzyl)-methylamino]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-mesyl-benzyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [4-[(4-chloro-2-methoxy-benzyl)-methylamino]piperidino]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[[(4-chloro-2-methoxy-benzyl)-methylamino]methyl]azetidin-1-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-methylthiazol-2-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylthiazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1,5-dimethylpyrazol-4-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2,4-dimethyloxazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 5-chloro-2-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methoxy]nicotinamide; [6-[(3-cyclopropyl-1H-pyrazol-5-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(2-methylpyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1-methylpyrazol-3-yl)methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[6-(trifluoromethyl)-3-pyridyl]oxymethyl]piperidino]methanone; 4-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-2-methoxy-benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-fluoro-4-(trifluoromethoxy)benzyl]oxypiperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-fluoro-4-(trifluoromethyl)benzyl]oxypiperidino]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[2-mesyl-4-(trifluoromethyl)benzyl]-oxypiperidino]methanone; 5-chloro-2-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]methoxy]nicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(2-methylsulfonylphenyl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; 4-[4-[1-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]phenyl]-1H-triazole-5-carbonitrile; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzoic acid methyl ester; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzoic acid methyl ester; 4-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzamide; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethoxy)benzamide; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [4-[[4-fluoro-3-(trifluoromethyl)phenoxy]methyl]piperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethoxy)phenoxy]methyl]piperidino]methanone; [4-(2-chloro-4-mesyl-benzyl)oxypiperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethyl)phenoxy]methyl]-piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [4-[[3-fluoro-5-(trifluoromethyl)phenoxy]methyl]piperidino]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[4-mesyl-3-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[4-[[2-mesyl-4-(trifluoromethoxy)phenoxy]methyl]-piperidino]methanone; [6-(5-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[4-[[4-mesyl-3-(trifluoromethyl)phenoxy]-methyl]piperidino]methanone; [4-(2-chloro-4-mesyl-benzyl)oxypiperidino]-[6-(5-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-dimethylphosphorylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.4]octan-2-yl]methanone; [3-[3-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.4]octan-2-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-fluorophenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-fluorophenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [2-(4-chloro-2-fluorophenyl)-6-azaspiro[3.4]octan-6-yl]-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(3-cyclopropyl-1,2,4-triazol-1-yl)phenyl]azetidin-1-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(3-dimethylphosphorylphenyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(5-fluoro-3-pyridyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [3-[6-(2-azaspiro[3.4]octan-2-yl)-3-pyridyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-mesylphenyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)-2-pyridyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[4-(trifluoromethyl)-2-pyridyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methoxy-5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]methyl]-5-(trifluoromethyl)-2-pyridone; 1-[[3-[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]azetidin-3-yl]-1-bicyclo[1.1.1]pentanyl]methyl]-4-(trifluoromethyl)-2-pyridone; [6-[3-(1-aminocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethylsulfonimidoyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-triflylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(methylsulfonimidoyl)-3-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-mesylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(difluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[3-(trifluoromethyl)isoxazol-5-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; 3-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(difluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)pyrazin-2-one; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(2,2,2-trifluoroethoxy)-3-pyridyl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]imidazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-isopropoxy-5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1S)-1-[4-methyl-5-(trifluoromethyl)-2-pyridyl]ethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1#H!-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(1#R!)-1-[4-methyl-5-(trifluoromethyl)pyridin-2-yl]ethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(1-triflylcyclopropyl)phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]oxy]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]oxymethyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(3,3,3-trifluoropropyl)pyrazol-3-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [3-[3-[difluoro-[4-(trifluoromethyl)phenyl]methyl]-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]-[6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[3-(3-methyl-1H-pyrazol-5-yl)-1-bicyclo[1.1.1]pentanyl]azetidin-1-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[4-(methylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-mesyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[2-[3-(trifluoromethyl)azetidin-1-yl]pyrimidin-5-yl]azetidin-1-yl]methanone; [4-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]piperazino]-(3-fluorophenyl)methanone; 4-[[1-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-4-piperidyl]oxymethyl]-2-methoxy-benzamide; [3-[4-(2-chloro-4-mesyl-phenyl)phenyl]azetidin-1-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[2-fluoro-4-(trifluoromethyl)phenyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[[1-(trifluoromethyl)cyclopropyl]amino]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[4-mesyl-3-(trifluoromethyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3,5-difluoro-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-indazol-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)imidazo[1,2-a]pyrazin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)imidazo[1,5-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-indazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; and [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-6-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

14. 14. A compound of formula (I) according to claim 13, selected from the following: or a pharmaceutically acceptable salt thereof: [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyrimidin-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1H-pyrazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)-2-pyridone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)triazol-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-methyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[6-(trifluoromethyl)pyridazin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[2-methyl-4-(trifluoromethyl)pyrazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-[3-(3,3-difluorocyclobutyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-(2-fluoro-4-triflyl-benzyl)oxyazetidin-1-yl]methanone; [6-[3-(1-hydroxycyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[5-[[1-(trifluoromethyl); 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-3-(trifluoromethyl)picolinonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[4-[3-(difluoromethyl)-5-methyl-1,2,4-triazol-1-yl]phenyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-[[5-(trifluoromethyl)isoxazol-3-yl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[7-(3-triflylbenzyl)-2,7-diazaspiro[3.4]octan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[3-[4-(trifluoromethylsulfonimidoyl)phenyl]azetidin-1-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-(trifluoromethyl)pyrimidin-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 4-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[5-(2,2-dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; 5-[[2-[6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)benzonitrile; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-triflylbenzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-(3-fluoro-5-triflyl-benzyl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[3-[3-[[5-(trifluoromethyl)pyrazin-2-yl]-amino]-1-bicyclo[1.1.1]-pentanyl]azetidin-1-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[2-methyl-5-(trifluoromethyl)triazol-4-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-3-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-(trifluoromethylsulfonimidoyl)-2-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(1-fluorocyclopropyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[[1-(trifluoromethyl); [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(5-triflyl-2-pyridyl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[6-(trifluoromethyl)-3-pyridyl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)nicotinonitrile; 5-[[2-[6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-2-(trifluoromethyl)isonicotinonitrile; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[fluoro-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(5-cyclopropyl-3-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[(3-cyclopropyl-5-methyl-pyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[2-fluoro-4-(trifluoromethylsulfonimidoyl)benzyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-[3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl]-2-azaspiro[3.3]heptan-2-yl]-[6-(4-triflylbenzyl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[4-(trifluoromethyl)pyrazol-1-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(5-cyclopropyl-4H-1,2,4-triazol-3-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-(trifluoromethyl)-1,2,4-thiadiazol-5-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[difluoro-[5-(trifluoromethyl)pyrazin-2-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[5-[1-(trifluoromethyl)cyclopropyl]-1H-pyrazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[(4-triflylpyrazol-1-yl)methyl]-2-azaspiro[3.3]heptan-2-yl]methanone; [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[3-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-5-yl]methyl]-2,6-diazaspiro[3.3]heptan-2-yl]methanone; 1-[[2-[6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptane-2-carbonyl]-2-azaspiro[3.3]heptan-6-yl]methyl]-5-(trifluoromethyl)pyrazin-2-one; and [6-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-azaspiro[3.3]heptan-2-yl]-[6-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]-2-azaspiro[3.3]heptan-2-yl]methanone.

15. A method for producing a compound of formula (I) according to any one of claims 1 to 3 or a pharmaceutically acceptable salt thereof, comprising reacting a compound of formula 2 【Chemistry 35】 (In the formula, R ３ and R ４ is as defined in any one of claims 1 to 3) by reacting a compound of formula 1 【Transformation 36】 (In the formula, R ３ and R ４ is as defined in any one of claims 1 to 3) with DMF or CH ３ reacting to form said compound of formula (I) by heating in the presence of a base such as DIPEA in a solvent such as CN.

16. A compound of formula (I) or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 3 for use as a therapeutically active substance.

17. A pharmaceutical composition comprising a compound of formula (I) according to any one of claims 1 to 3 or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.

18. 18. The pharmaceutical composition of claim 17 for the treatment or prevention of neuroinflammation, neurodegenerative diseases, pain, cancer, psychiatric disorders, and / or inflammatory bowel disease in a mammal.

19. 19. The pharmaceutical composition of claim 18, wherein the neuroinflammation, neurodegenerative disease, pain, cancer and psychiatric disorder is selected from multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, epilepsy, anxiety, migraine, depression, hepatocellular carcinoma, colon carcinogenesis, ovarian cancer, neuropathic pain, chemotherapy-induced neuropathy, acute pain, chronic pain, pain-associated spasticity, abdominal pain, abdominal pain and / or visceral pain associated with irritable bowel syndrome.

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