Double chamber internal circulation sealed liquid medicine transfer device and liquid medicine transfer system

Abstract

The present invention discloses a double-chamber internal circulation sealed liquid medicine transfer device and transfer system, the liquid medicine transfer device includes a double-chamber syringe 10, a dispensing needle assembly 20, and a needle seal assembly 30. The product structure of the present invention is exquisitely designed and easy to assemble, can realize completely sealed preparation and transfer of medicine, can automatically or manually adjust and balance the air pressure in the medicine container during use, can minimize the risk of drug leakage, has excellent sealing effect, low cost, and is convenient to use.

Description

[Technical field]

[0001] The present invention relates to the field of drug preparation and delivery devices, and more particularly to a double-chamber internal circulation sealed drug delivery device and drug delivery system. [Background technology]

[0002] Hazardous drugs, such as chemotherapy drugs, pose great harm to the health of medical personnel who are engaged in the preparation and transport of such drugs for a long time, such as carcinogenesis, damage to internal organs, DNA damage, reproductive problems, miscarriage, and teratogenesis. According to previous data, the cancer incidence rate of pharmacists, nurses, and other personnel who have long-term contact with hazardous drugs is 3 to 10 times higher than that of the general public, and the risk of infertility or miscarriage is 2 to 5 times higher. Therefore, some medical institutions have built various purification rooms, biocabinets, and other facilities to reduce the risk of drug leakage, but although they have made large investments, the actual application effect is not good. In the domestic medical treatment stage, there is a large demand for sealed drug liquid transporters, but there are few options, and products are required to have good sealing properties, low cost, and convenient use. In recent years, BD, an American company, has launched a sealed configuration and transport system, but it is difficult to popularize due to its complex structure, high cost, and complicated operation, and the system can only reduce the risk of leakage by 50 to 80%. The applicant of the present invention has previously launched two types of medicinal liquid transfer devices (CN111346008A and CN111346009A) equipped with airbags for pneumatic pressure balancing, which are low-cost, convenient to use and have relatively good internal circulation sealing effect. However, in popular applications, some problems have been found, such as the airbag structure being easily damaged / detached, and the channel connecting the airbag being easily blocked by the medicinal liquid, so there is still a certain risk of leakage. Summary of the Invention [Problem to be solved by the invention]

[0003] In response to the shortcomings of the prior art and the needs of practical applications, the object of the present invention is to provide a double-chamber internal circulation sealed drug liquid transfer device and transfer system, which has an intricately designed structure and is easy to assemble, and can realize completely sealed drug preparation and transfer. During the use process, the air pressure inside the drug container can be automatically or manually adjusted to achieve balance, thereby minimizing the risk of drug leakage. It has the advantages of excellent sealing effect, low cost, and high convenience of use. [Means for solving the problem]

[0004] In order to achieve the above object, a first aspect of the present invention provides a double-chamber internal circulation sealed drug liquid transfer device, which includes a double-chamber syringe, a dispensing needle assembly, and a needle seal assembly, The double-chamber syringe comprises a first syringe barrel, a first piston rod that can slide back and forth along an internal cavity within the first syringe barrel, a second syringe barrel, and a second piston rod that can slide back and forth along an internal cavity within the second syringe barrel, wherein the first syringe barrel and the second syringe barrel are arranged side by side, facing in the same direction, and fixedly installed in a manner that the front ends are flush with each other, a first joint is installed on the front end surface of the first syringe barrel, and a second joint is installed on the front end surface of the second syringe barrel; The dispensing needle assembly includes a dispensing needle and a needle hub, the dispensing needle being fixedly connected to the needle hub in a manner that the rear end of the dispensing needle is embedded in the front end of the needle hub, wherein: The needle hub has a rear end provided with a first connecting hole corresponding to the first joint and a second connecting hole corresponding to the second joint, and the needle hub has an inside provided with a first channel and a second channel communicating with the first connecting hole and the second connecting hole respectively and independent of each other; The dispensing needle has a double-layered columnar structure and has an inner column channel and a side ring channel, where the inner column channel communicates with the first channel and the side ring channel communicates with the second channel; The first joint and the second joint are respectively embedded in the first connecting hole and the second connecting hole, so that the dispensing needle assembly and the double-chamber syringe achieve a fixed and sealed connection; The needle seal assembly includes a sheath disposed coaxially with the dispensing needle, a sealing member, and a resilient member, wherein: The sheath is a hollow cylindrical structure that is open at the front and rear, and is axially movable at the front end of the needle hub. The sealing member is made of an elastic material and is fixedly installed in the front end of the sheath. The central axis of the sealing member is provided with a hole through which the dispensing needle passes, and the inner diameter of the hole is smaller than the outer diameter of the dispensing needle. a resilient member disposed between the closure member and the needle hub, the resilient member providing axial resilient support to the closure member at the front end, depending on the needle hub; In the non-pressurized state, the elastic member expands in the axial direction, and the sheath shields the dispensing needle inside the sheath. At the same time, the sealing member tightly encloses the front end of the dispensing needle due to the elastic action of the elastic material, and seals the front end channel mouths of the inner column channel and the side ring channel inside; In the pressurized state, the elastic member is compressed in the axial direction, and the front end of the dispensing needle, including the inner column channel and the front end channel mouth of the side ring channel, can exit the sheath through the hole tube of the sealing member.

[0005] In the present invention, unless otherwise specified, the front end refers to the end pointed to by the tip of the dispensing needle, and the rear end refers to the other end opposite thereto.

[0006] In the sealed liquid medicine transfer device of the present invention, the double-chamber syringe is composed of a first syringe barrel, a first piston rod that can slide back and forth along the inner cavity in the first syringe barrel, a second syringe barrel, and a second piston rod that can slide back and forth along the inner cavity in the second syringe barrel, and the first syringe barrel and the second syringe barrel are arranged side by side, in the same direction, and fixed in a manner that the front ends are flush with each other. The present invention does not particularly limit the specifications of the first syringe barrel and the second syringe barrel, and the two can be the same or different, but in consideration of the convenience of production and actual operation, in a preferred embodiment, the first syringe barrel and the second syringe barrel have the same size specifications. Preferably, the first syringe barrel and the second syringe barrel are made of a transparent material, and a scale indicating the volume is provided on the surface of the barrel.

[0007] The function of the joint on the front end surface of the syringe barrel is mainly embodied in two aspects, namely, one is a plug-in fixed connection part between the double-chamber syringe and the dispensing needle assembly, and the other is an inlet / outlet for the drug liquid or gas to enter and exit the syringe barrel. In view of the size limitation of the needle hub, preferably, the first joint and the second joint are installed in a manner as close as possible.

[0008] In a preferred embodiment, the outer walls of the first and second couplings are tapered surfaces, and at least one annular boss is provided on the tapered surfaces. Accordingly, the shapes of the first and second connecting holes provided at the rear end of the needle hub respectively match the tapered surfaces of the corresponding couplings, and an annular groove corresponding to the annular boss is provided on the hole wall. Through the insertion and fixing of the couplings and the connecting holes, a fixed and sealed connection between the dispensing needle assembly and the dual-chamber syringe can be easily achieved.

[0009] In the closed type drug solution transfer device of the present invention, the dispensing needle assembly includes a dispensing needle and a needle hub, and the dispensing needle is fixedly connected to the needle hub in a manner that the rear end of the dispensing needle is embedded in the front end of the needle hub.

[0010] The dispensing needle has a double-layered columnar structure, and has an inner column channel and a side ring channel. In a preferred embodiment, the dispensing needle can be composed of an inner needle tube and an outer needle tube, the inner needle tube is drilled into the outer needle tube, and both ends extend outside the outer needle tube, at which time the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer needle tube and the inner needle tube.

[0011] The inner needle tube and the outer needle tube may be independent of each other, or may be integrally molded and fixedly connected to each other. If the latter type is selected, preferably the front end of the outer needle tube is hermetically fixedly connected to the front end side wall of the inner needle tube. More preferably, the front end of the inner needle tube is set to an oblique opening, or the front end of the inner needle tube is a tip and a side opening is set, and the front end side wall of the outer needle tube is set to a side opening. Designing the opening in this way is not only advantageous for the dispensing needle to pierce the drug container, but also can reduce the interference between both the inner column channel and the side ring channel, and when the side ring channel is the drug liquid channel, the side opening set at the rear is more suitable for the medical staff's operation habit of inverting the liquid drug bottle when preparing the drug, and is more advantageous for the medical staff to more fully aspirate the drug liquid (especially the drug liquid at the bolt mouth), avoiding the waste of the drug or the increased operation risk caused by secondary operations.

[0012] The needle hub is a carrier for mounting the dispensing needle and the needle seal assembly. As mentioned above, the rear end of the needle hub is provided with a first connecting hole matching the first joint and a second connecting hole matching the second joint, and the inside of the needle hub is provided with a first channel and a second channel respectively communicating with the first connecting hole and the second connecting hole and being independent from each other, the inner column channel of the dispensing needle communicates with the first channel, and the side ring channel communicates with the second channel.

[0013] In a preferred embodiment, a mounting groove is provided at the front end of the needle hub, and a needle threading stand (corresponding to a lump excavated from the front end of the needle hub) whose external structure matches the mounting groove is installed in the mounting groove, the front end openings of the first channel and the second channel are both located at the bottom of the mounting groove, and the position of the front end opening of the first channel is coaxial with the prescription needle, the inside of the needle threading stand is provided with a hole tube that penetrates from front to back at a position corresponding to the axis of the prescription needle, and is composed of a needle threading hole located at the front and a fixing hole located at the rear, the needle threading hole is trumpet-shaped, and the inner diameter to the fixing hole gradually decreases from front to rear, the inner diameter of the fixing hole matches the outer diameter of the outer needle tube, and a connecting groove is provided on the rear end surface of the needle threading stand, and both ends are connected to the second channel and the fixing hole respectively. The rear end of the inner needle tube of the dispensing needle is fixed in the first channel through the needle threading base in an embedding manner, and the rear end of the outer needle tube is fixed in the fixing hole of the needle threading base in an embedding manner.

[0014] More preferably, in the above embodiment, a first channel in the needle hub is disposed in a manner that is coaxial with the dispensing needle, and a second channel is disposed parallel to one side of the first channel.

[0015] More preferably, the cross section of the needle passer is not circular and maintains no change along the axial direction. The purpose of this design is to allow the needle passer to be mounted in the mounting groove of the needle hub only at a fixed angle, and to facilitate accurate alignment of the communicating groove at the bottom of the needle passer with the second channel.

[0016] After fully understanding the structure of the needle hub and the dispensing needle, how to assemble the dispensing needle assembly can be easily determined by those skilled in the art. For example, when the dispensing needle is composed of an inner needle tube and an outer needle tube independent of each other, the needle passer can be taken out first, the rear end of the inner needle tube is embedded in the first channel, and then the outer needle tube is fixed to the needle passer, and the integrated outer needle tube and the needle passer can be set outside the inner needle tube and inserted into the mounting groove; or when the inner needle tube and the outer needle tube are integrally formed and fixedly connected to each other, the needle passer can be taken out first, the dispensing needle can be fixed to the needle passer, and the rear end of the outer needle tube is embedded in the fixing hole of the needle passer and penetrates the rear end of the inner needle tube and comes out of the needle passer, and then the needle passer can be inserted into the mounting groove, and the exposed rear end of the inner needle tube can be completely embedded in the first channel.

[0017] After the dispensing needle assembly and the double-chamber syringe are fixed and hermetically connected, the inner column channel, the first channel, the first connecting hole and the first syringe communicate from front to rear to form a sealed passage I, and the side ring channel, the second channel, the second connecting hole and the second syringe communicate from front to rear to form a sealed passage II. The sealed passages I and II are independent of each other, and in the process of preparing and transferring the medicinal liquid, one of the two passages can be used to transfer the medicinal liquid, and the other can transfer gas and play the role of balancing air pressure.

[0018] In the present invention, the needle seal assembly includes a sheath, a sealing member, and an elastic member, which are arranged coaxially with the dispensing needle. The needle seal assembly can not only achieve the function of preventing needle penetration, but also ensure that the entire process of preparing and transferring the medicinal liquid is completely sealed, and avoid the risk of the medicinal liquid leaking from the front end channel. Assemblies with similar structure and function have been reported in the applicant's previous patents, such as CN111346008A and CN111346009A, but their manufacturing processes are relatively complex, and require the use of parts with relatively complex structures, and cannot be achieved by combining simple structural parts, so that they require the use of specific equipment during batch production, or the requirements for the precision of the equipment are relatively high.

[0019] In order to realize the purpose of simplifying the manufacturing process, easy assembly, and reducing the batch production cost, the applicant optimized the structure of the needle seal assembly. In a preferred embodiment of the present invention, the needle seal assembly includes a sheath, a sealing member, an elastic member, and an inner sleeve, which are coaxially arranged, wherein: a front end of the sheath having a smaller radial size and forming a composite tubular structure having a first tubular segment having a relatively small inner diameter and a second tubular segment having a relatively large inner diameter; the sealing member is designed as an inverted T-shaped structure in cross section, with a front diameter corresponding to the inner diameter of the first cylindrical segment and a rear diameter corresponding to the inner diameter of the second cylindrical segment, so that the sealing member can completely fill the inner cavity of the first cylindrical segment and at the same time fill at least a part of the inner cavity of the second cylindrical segment; The inner sleeve has an inner diameter corresponding to the outer diameter of the needle hub, the inner sleeve has an outer diameter corresponding to the inner diameter of the second cylindrical segment of the sheath, the front end surface of the inner sleeve is sealed, and the center of the end surface is provided with a through hole for the dispensing needle to pass through, the inner sleeve is fixedly connected in the second cylindrical segment of the sheath, and the front end surface abuts against the rear end surface of the sealing member; The elastic member is disposed within the inner sleeve, and both ends abut against the inner surface of the front end of the inner sleeve and the front end surface of the needle hub, respectively.

[0020] The structure of the sheath and the sealing member is improved, and an inner sleeve is added, so that the sealing member is fixed by a stopper, and both the front and rear ends of the elastic member are abutted against a hard material, making the overall structure and performance more stable. More preferably, a buckle is provided on the outer wall of the inner sleeve, and a corresponding locking hole is provided on the second cylindrical segment of the sheath, so that the buckle and the locking hole cooperate to realize a fixed connection between the sheath and the inner sleeve when the inner sleeve is inserted into the sheath. Preferably, a ring boss is provided at the rear end opening of the inner sleeve in a radially outward manner, so that when the front end face of the inner sleeve abuts against the rear end face of the sealing member, the ring boss at the rear end is exposed from the sheath and abuts against the rear end of the sheath.

[0021] It is easy to understand that in the process of using the drug solution transfer device of the present invention, the needle seal assembly moves in the axial direction with the expansion and contraction of the elastic member, but always maintains a state of being connected to the needle hub. In one preferred embodiment, the inner surface of the front end of the inner sleeve and the front end surface of the needle hub are both provided with a buckle structure, thereby realizing a fixed connection with the elastic member. In another preferred embodiment, the side of the needle hub is provided with an L-shaped groove consisting of an axial groove and a lateral groove (a groove perpendicular to the axial direction), and the rear end of the inner sleeve is provided with a slide table radially inwardly, which is embedded in the L-shaped groove and can slide along the groove. The position design of the slide table and the L-shaped groove can flexibly adjust and limit the movable range of the needle seal assembly relative to the needle hub. As the slide table slides backward along the axial groove, the elastic member is compressed, and the dispensing needle breaks through the sealing member. After reaching a set degree, the slide table rotates along the lateral groove, thereby limiting the axial movement of the needle seal assembly, thereby achieving the effect of fixing the stopper.

[0022] The sealing member is made of an elastic material, preferably made of any one of rubber, silica gel, and synthetic rubber. The applied elastic material should comply with the relevant standards of medical materials, which is easily known and determined by those skilled in the art. In a preferred embodiment, the front end surface of the sealing member protrudes outward from the front end surface of the sheath, so that the sealing member made of an elastic material can fit the opening of the drug container and better seal the opening of the drug container during preparation and transfer of the drug solution.

[0023] The resilient member may be a resilient collapsible tube, a spring, or the like, and is preferably a spring.

[0024] When the sealed drug liquid transfer device of the present invention is used in cooperation with a liquid transfer connector to prepare and transfer drug liquid, in order to facilitate fixed connection with the liquid transfer connector, two engaging platforms that are convex radially outward are preferably provided symmetrically on the outer wall of the front end of the sheath.

[0025] In the sealed liquid medicine transfer device of the present invention, in a non-pressurized state, the elastic member stretches in the axial direction, and the sheath shields the dispensing needle inside the sheath, and the sealing member tightly encloses the front end of the dispensing needle and seals the front end channel mouth of the inner column channel and the side ring channel inside due to the elastic action of the elastic material, and in a pressurized state, the elastic member is compressed in the axial direction, and the front end of the dispensing needle including the inner column channel and the front end channel mouth of the side ring channel can exit from the sheath through the hole tube of the sealing member. The initial state of the sealed liquid medicine transfer device may be in a non-pressurized state or a pressurized state, but for the purpose of preventing needle penetration, avoiding contamination, and avoiding inertial deformation of the elastic member and the sealing member, the initial state is preferably in a non-pressurized state.

[0026] Preferably, the closed drug liquid transfer device of the present invention further includes a protective cap, which is set on the sheath in a standby state to avoid potential contamination risks.

[0027] In a second aspect of the present invention, there is further provided a closed liquid drug transfer system, the system comprising: The device includes a double chamber internal circulation sealed type drug solution transfer device and a liquid transfer connector for fixing and connecting the drug solution transfer device to a drug container, One end of the liquid transfer connector is used for removably fixing and connecting the drug container, and the other end is used for removably fixing and connecting the drug liquid transporter, and when fixedly connected, the front end face of the sealing member abuts against the container mouth of the drug container.

[0028] In one preferred embodiment, the liquid transfer connector includes a first sleeve and a second sleeve coaxially connected to each other, the first sleeve is used to be removably fitted to the front end of the sheath of the drug liquid transport device, and the second sleeve is used to be removably fitted to the container mouth of the drug container, and when fixedly connected, the front end face of the sealing member and the container mouth of the drug container maintain stable abutment within the sleeve.

[0029] More preferably, buckle claws extending axially forward are symmetrically arranged on the outer edge of the second sleeve, and a release arm extending rearward is arranged at the rear end of each buckle claw, so that the second sleeve is fixed to the container mouth via the buckle claws and removed from the container mouth via the release arms.

[0030] More preferably, two engagement grooves are symmetrically provided on the inner wall of the first sleeve, the engagement groove being an L-shaped structure consisting of an axial groove and a lateral groove, and two engagement platforms that are convex radially outward are symmetrically provided on the outer wall of the front end of the sheath accordingly. When the sheath is inserted into the first sleeve, the engagement platforms synchronously enter the axial grooves of the engagement grooves, and after reaching a predetermined position, the drug solution transporter is rotated so that the engagement platforms rotate into the lateral grooves, and the drug solution transporter can be fixed to the liquid transfer connector, and can be removed and separated by operating in the opposite direction.

[0031] The sealed liquid medicine transfer device of the present invention has the feature of double-chamber internal circulation, in which the sealed passages I and II are independent of each other, the sealed passage I communicates with the first syringe and the drug container, and the sealed passage II communicates with the second syringe and the drug container. After the front end of the dispensing needle is inserted into the drug container, one of the first syringe and the second syringe is used to transfer the liquid medicine, and the other can cooperate with the air previously drawn into the syringe by the back and forth movement of the piston rod to achieve the purpose of air pressure equilibrium.

[0032] The sealed liquid medicine transfer device of the present invention may be used for the purpose of preparing a mixed drug and transferring the prepared liquid medicine into an infusion bottle or an indwelling needle, etc. With a full understanding of the structure of the above-mentioned sealed liquid medicine transfer device and transfer system of the present invention, a person skilled in the art can easily determine how to use it to prepare and transfer a liquid medicine.

[0033] Taking the example of preparing a medicinal liquid (involving dissolving powdered medicine) and injecting it into an infusion bottle, a flow for using the medicinal liquid transfer system of the present invention may include the following steps.

[0034] (1) The first piston rod of the double-chamber syringe is pulled backward until the volume of the front cavity of the first syringe barrel becomes larger than the volume of the medicinal liquid to be prepared. To carry out this gas storage step, the dispensing needle may be pierced through the sealing member in advance and reset after gas storage, or the double-chamber syringe may be separated from the dispensing needle assembly and re-fixed and connected to the dispensing needle assembly after gas storage.

[0035] (2) The second sleeve of the infusion connector A is fitted onto the bolt mouth of the infusion bottle and fixed to it using a buckle claw. Then, the sheath of the drug solution transfer device (where the engagement base is provided) is held and aligned, and inserted into the first sleeve (where the engagement groove is provided) of the infusion connector A, and rotated to fix it. At this time, the front end face of the sealing member and the back mouth of the infusion bottle abut within the sleeve.

[0036] (3) Hold the syringe barrel of the drug solution transfer device and push it forward. As the spring compresses, the dispensing needle penetrates the sealing member and pierces the infusion bottle. After it is completely pierced, rotate the syringe barrel (e.g., clockwise) to stopper the needle seal assembly and the needle hub.

[0037] (4) The second piston rod of the double-chamber syringe is pulled to extract a portion of the medicinal liquid (e.g., saline) in the infusion bottle into the second syringe barrel through the sealed passage II. At this time, negative pressure is generated in the infusion bottle. Under the action of the pressure difference between the inside and outside, the first piston rod advances until the air pressures inside and outside the bottle are equilibrated, and the air reserved in the first syringe barrel is replenished into the infusion bottle.

[0038] (5) After the extraction of the medicinal liquid is completed, the syringe barrel is rotated in the opposite direction (e.g., counterclockwise) to release the stopper fixing between the needle seal assembly and the needle hub, and under the assistance of the elastic potential energy of the spring, the double-chamber syringe and the dispensing needle assembly are moved backward until the dispensing needle is reset, and then withdrawn from the infusion bottle and resealed by the sealing member.

[0039] (6) Twist the sheath of the drug solution transfer device to release the fixed connection between the drug solution transfer device and the liquid transfer connector A, and pull it out from the liquid transfer connector A.

[0040] (7) The second sleeve of the liquid transfer connector B is fitted onto the bolt mouth of the vial and fixed to it using a buckle claw, and then the first sleeve (having an engagement groove) of the liquid transfer connector B is inserted while holding the sheath of the drug liquid transfer device to align it, and then rotated to fix it. At this time, the front end face of the sealing member and the back mouth of the vial abut within the sleeve.

[0041] (8) Hold the syringe barrel of the drug solution transfer device and push it forward. As the spring compresses, the dispensing needle penetrates the sealing member and pierces the vial. After it is completely pierced, rotate the syringe barrel (e.g., clockwise) to stopper the needle seal assembly and the needle hub.

[0042] (9) By pressing the second piston rod of the double-chamber syringe, the medicinal liquid is injected from the second syringe barrel through sealed passage II into the vial. At this time, positive pressure is generated in the vial, and the air therein automatically flows into the first syringe barrel through sealed passage I, causing the first piston rod to retract.

[0043] (10) After the medicinal liquid injected into the vial has sufficiently dissolved the original powder in the vial, the second piston rod is pulled, and the mixed medicinal liquid in the vial is extracted into the second syringe through the sealed passage II. At this time, negative pressure is generated in the vial, and the gas in the first syringe is automatically replenished into the vial. Under the action of the pressure difference between the inside and outside of the first piston rod, it moves forward until the air pressure inside and outside are equilibrated.

[0044] (11) After the extraction of the mixed medicinal liquid is completed, reset the dispensing needle and pull out the medicinal liquid transfer device from the liquid transfer connector B, referring to steps (5) and (6).

[0045] (12) Hold the sheath of the drug solution transfer device and realign it, then insert the first sleeve of the infusion connector A and rotate it to fix it in place, so that the front end face of the sealing member and the mouth of the infusion bottle abut again inside the sleeve.

[0046] (13) After operating with reference to step (3), press the second piston rod of the double-chamber syringe, and the mixed liquid is injected from the second syringe barrel through the sealed passage II into the infusion bottle. At this time, a positive pressure is generated in the infusion bottle, and the air therein automatically enters the first syringe barrel through the sealed passage I, causing the first piston rod to retract.

[0047] (14) After the mixed medicinal liquid is completely injected into the infusion bottle, reset the dispensing needle and pull out the medicinal liquid transfer device from the infusion connector A, referring to steps (5) and (6).

[0048] During the preparation and delivery process, the second syringe delivers the liquid medicine through the sealed passage II, and the first syringe moves back and forth by the first piston rod, and balances the air pressure inside and outside the delivery system together with the air previously drawn into the first syringe. The back and forth movement of the first piston rod can be completed only by the pressure difference between the inside and outside without the aid of external force, or can be flexibly adjusted by manual assistance. Effect of the Invention

[0049] Compared with the prior art, the beneficial effects of the present invention include at least the following aspects:

[0050] (1) The structure of the drug solution transfer device of the present invention is intricately designed, and each component is easy to produce and assemble in batches, eliminating the need for components with relatively complex structures and the need for specific equipment.

[0051] (2) The product has stable structure and performance, low cost, high yield and easy use.

[0052] (3) During the process of drug preparation and delivery, the air pressure inside and outside the drug delivery system is perfectly balanced.

[0053] (4) It can realize completely sealed drug preparation and transfer, minimize the risk of drug leakage, and has excellent sealing effect.

[0054] The invention will be further explained below in conjunction with the drawings. [Brief description of the drawings]

[0055] [Figure 1] 1A and 1B are schematic cross-sectional views of a drug solution transferring device according to a first embodiment, in which FIG. 1A is the drug solution transferring device in a non-pressurized state, and FIG. 1B is the drug solution transferring device in a pressurized state. [Diagram 2]2A and 2B are schematic cross-sectional views of a perspective view of a drug solution transferring device of the first embodiment, in which FIG. 2A is the drug solution transferring device in a non-pressurized state, and FIG. 2B is the drug solution transferring device in a pressurized state. [Diagram 3] FIG. 1 is a representative diagram of a drug transfer device. [Figure 4] 4A is a schematic diagram of the cross-sectional structure of a drug liquid transfer device and a liquid transfer connector in the drug liquid transfer system of Example 2, where FIG. 4A is in a non-connected state, FIG. 4B is in a connected state, and FIG. 4C is in a running state of the drug liquid transfer system. [Diagram 5] FIG. 1 is a representative illustration of a drug delivery system. [Figure 6] FIG. 1 is an actual diagram of the detection results using a three-purpose ultraviolet analysis device in application example 1. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0056] In order to better explain the objectives, technical solutions and advantages of the present invention, the specific embodiments of the present invention will be described in more detail below in conjunction with the drawings and examples. The following examples are provided to illustrate the present invention but are not intended to limit the scope of the present invention.

[0057] Example 1 As shown in FIG. 1, the double-chamber internal circulation sealed liquid medicine transfer device includes a double-chamber syringe 10, a dispensing needle assembly 20, and a needle seal assembly 30.

[0058] The double-chamber syringe 10 is composed of a first syringe barrel 11, a first piston rod 12 that can slide back and forth along the inner cavity in the first syringe barrel 11, a second syringe barrel 14, and a second piston rod 15 that can slide back and forth along the inner cavity in the second syringe barrel 14. Here, the first syringe barrel 11 and the second syringe barrel 14 are made of a transparent material, and both have the same specifications, are arranged side by side, are oriented in the same direction, and are fixedly installed in a manner that the front ends are flush with each other, and a scale (not shown) that indicates the volume is installed on the surface of the cylinder. A first joint 13 and a second joint 16 are installed on the front end surfaces of the first syringe barrel 11 and the second syringe barrel 14, respectively, in a manner close to each other, and the structure of the two joints is the same, and both outer walls are tapered surfaces, and the tapered surfaces do not have a single annular boss (not shown).

[0059] The dispensing needle assembly 20 includes a dispensing needle 21 and a needle hub 22 .

[0060] The dispensing needle 21 is a two-layer columnar structure consisting of an inner needle tube and an outer needle tube fixed to each other. The inner needle tube is longer than the outer needle tube, and both ends extend to the outside of the outer needle tube, and the front end of the outer needle tube is hermetically fixed and connected to the front end side wall of the inner needle tube. The front end opening of the inner needle tube is an oblique opening, and the front end of the outer needle tube is provided with a side opening. Thus, the inner cavity of the inner needle tube forms an inner column channel 211, and the side ring channel 212 is formed by the cavity between the outer needle tube and the inner needle tube.

[0061] The rear end of the needle hub 22 is provided with a first connecting hole 221, which matches the position and shape of the first joint 13, and a second connecting hole 223, which matches the position and shape of the second joint 16. The inside of the needle hub 22 is provided with a first channel 222 and a second channel 224, which are connected to the first connecting hole 221 and the second connecting hole 223 respectively and are independent of each other, where the first channel 222 is arranged coaxially with the dispensing needle 21, and the second channel 224 is arranged parallel to one side of the first channel 222.

[0062] The front end of the needle hub 22 is provided with a mounting groove with an elliptical cross section, and the front end openings of the first channel 222 and the second channel 224 are both located at the bottom of the mounting groove. The needle pass-through base 23, whose external structure matches the mounting groove, is installed in the mounting groove, and the inside of the needle pass-through base 23 is provided with a hole tube that penetrates from front to back at the axis position of the corresponding prescription needle 21, and is composed of a needle pass-through hole located at the front and a fixing hole located at the rear, where the needle pass-through hole is trumpet-shaped (to facilitate the installation of the prescription needle 21), and the inner diameter to the fixing hole gradually decreases from front to rear, and the inner diameter of the fixing hole matches the outer diameter of the outer needle tube. The rear end surface of the needle pass-through base 23 is further provided with a communication groove, and both ends are respectively connected to the second channel 224 and the fixing hole.

[0063] The dispensing needle 21 is fixedly connected to the needle hub 22 by embedding its rear end in the needle hub 22. At this time, the rear end of the inner needle tube passes through the hole tube of the needle passer 23 and is fixed in the first channel 222 by embedding, and the rear end of the outer needle tube passes through the needle passer hole and is fixed in the fixing hole of the needle passer 23 by embedding.

[0064] By embedding the first coupling 13 and the second coupling 16 into the first connecting hole 221 and the second connecting hole 223 respectively, the dispensing needle assembly 20 and the dual chamber syringe 10 achieve a fixed and sealed connection.

[0065] Needle seal assembly 30 includes a coaxially disposed sheath 31, a sealing member 32, a resilient member 33, and an inner sleeve 34.

[0066] The front end of the sheath 31 has a relatively small radial size and forms a composite cylindrical structure composed of a first cylindrical segment with a relatively small inner diameter and a second cylindrical segment with a relatively large inner diameter. Two engagement bases that protrude radially outward are symmetrically provided on the outer wall of the first cylindrical segment for fixed connection to the liquid transfer connector, and two locking holes are symmetrically provided on the cylindrical wall near the rear end opening of the second cylindrical segment.

[0067] The sealing member 32 is made of silica gel, and its cross section has an inverted T-shaped structure, its front diameter is equal to the inner diameter of the first cylindrical segment of the sheath 31, its length is slightly longer than the axial length of the first cylindrical segment, and its rear diameter is equal to the inner diameter of the second cylindrical segment. The sealing member 32 completely fills the inner cavity of the first cylindrical segment and the inner cavity of the front end of the second cylindrical segment, and its front end surface protrudes outward beyond the front end surface of the sheath 31. The central axis of the sealing member 32 is provided with a hole tube through which the dispensing needle 21 passes, and the inner diameter of the hole tube is smaller than the outer diameter of the dispensing needle 21.

[0068] The inner diameter and outer diameter of the inner sleeve 34 correspond respectively to the outer diameter of the needle hub 22 and the inner diameter of the second cylindrical segment of the sheath 31. Its front end face is sealed, and a through hole is provided in the center of the end face for the dispensing needle 21 to pass through. A ring boss is provided at the rear end opening in a radially outward manner, and two buckles matching the locking holes are symmetrically provided on the outer wall adjacent to the rear end opening.

[0069] The inner sleeve 34 is inserted into the second cylindrical segment of the sheath 31, and a fixed connection between the two is realized by cooperation of the buckle and the locking hole, and the front end surface of the inner sleeve 34 abuts against the rear end surface of the sealing member 32, and the annular boss at the rear end is exposed from the sheath 31 and abuts against the rear end of the sheath 31.

[0070] The elastic member 33 is a spring that is disposed within the inner sleeve 34, and both ends of the elastic member 33 abut against the inner surface of the front end of the inner sleeve 34 and the front end surface of the needle hub 22, respectively.

[0071] An L-shaped groove consisting of two axial grooves and a lateral groove is symmetrically arranged on the side of the needle hub 22, and accordingly, two slide tables are symmetrically arranged inwardly in the radial direction of the rear end of the inner sleeve 34, and the slide tables are embedded in the L-shaped groove and can slide along the groove.

[0072] As shown in FIG. 1a, the sealed liquid transporter is in a non-pressurized state, the elastic member stretches in the axial direction, the sliding table of the inner sleeve 34 is located at the front end of the axial groove on the side of the needle hub 22, the sheath 31 shields the dispensing needle 21 inside the sheath 31, and under the elastic action of the silica gel, the sealing member 32 tightly encloses the front end of the dispensing needle 21 and seals the front end channel mouths of the inner column channel 211 and the side ring channel 212 inside.

[0073] 1a, the dispensing needle assembly 20 is fixedly and hermetically connected to the double-chamber syringe 10, the inner column channel 211, the first channel 222, the first connecting hole 221 and the first syringe barrel 11 communicate from front to rear to form a sealed passage I, and the side ring channel 212, the second channel 224, the second connecting hole 223 and the second syringe barrel 14 communicate from front to rear to form a sealed passage II. The sealed passages I and II are independent of each other.

[0074] 1b is a schematic cross-sectional view of the above-mentioned drug solution transfer device in an axial pressure state. In the pressure state, the spring is compressed in the axial direction, and the front end of the dispensing needle 21, including the inner column channel 211 and the front end channel port of the side ring channel 212, exits from the sheath 31 through the hole tube of the sealing member 32. The sliding table of the inner sleeve 34 slides backward synchronously along the axial groove, and moves into the lateral groove through the rotating double-chamber syringe 10 or the sheath 31, thereby limiting the axial movement of the needle seal assembly 30 and achieving the effect of fixing the stopper.

[0075] 2a and 2b are schematic cross-sectional views of the liquid medicine transfer device in a non-pressurized and pressurized state.

[0076] Fig. 3 is a representative real-life view of the drug solution delivery device of the present invention, in which Fig. 3a is a sample real-life view in a preliminary state, Fig. 3b is a sample real-life view after the double-chamber syringe, the dispensing needle assembly and the needle seal assembly are separated from each other, and Fig. 3c is a sample real-life view after each component is separated (in order to show the internal structure more comprehensively and clearly, the inner needle tube and the outer needle tube of the dispensing needle are presented separately here).

[0077] Example 2 Shown in FIG. 4 is a closed type drug liquid transfer system, which includes a double-chamber internal circulation closed type drug liquid transfer device (as shown in FIGS. 1 to 3, not shown in full in FIG. 4) and a liquid transfer connector 40 for fixing and connecting the drug liquid transfer device to a drug container.

[0078] The fluid transfer connector 40 includes a first sleeve 41 and a second sleeve 42 that are coaxially connected to each other.

[0079] The first sleeve 41 is used to be removably fitted on the front end of the sheath 31 of the drug solution transferring device. Two engagement grooves 45 are symmetrically installed on the inner wall of the first sleeve 41 corresponding to the engagement base on the outer wall of the front end of the sheath 31, and the engagement grooves 45 have an L-shaped structure composed of an axial groove and a lateral groove. When the sheath 31 is inserted into the first sleeve 41, the engagement bases synchronously enter the axial grooves of the engagement grooves, and after reaching a predetermined position, the drug solution transferring device is rotated so that the engagement bases rotate into the lateral grooves, and the drug solution transferring device can be fixed to the liquid transfer connector.

[0080] The second sleeve 42 is adapted to be removably fitted to the opening of a drug container. Buckle claws 43 extending axially forward are symmetrically provided on the outer edge of the second sleeve 42, and a release arm 44 extending rearward is provided at the rear end of each buckle claw 43. The second sleeve 42 is fixed to the opening of the container through the buckle claws 43 and removed from the opening of the container through the release arm 44.

[0081] When the drug solution transporter and the drug container are fixedly connected via the liquid transfer connector 40, the front end face of the sealing member 32 and the container mouth of the drug container maintain stable contact within the sleeve.

[0082] In the liquid medicine transfer system shown in Fig. 4a, the liquid medicine transfer device and the liquid transfer connector are in an unconnected state. Fig. 4b is a schematic cross-sectional view of the liquid medicine transfer device and the liquid transfer connector in a connected state in the liquid medicine transfer system. Fig. 4c is a schematic cross-sectional view of the liquid medicine transfer system in an operating state.

[0083] Fig. 5 is a representative view of the liquid medicine transfer system of the present invention, in which Fig. 5a is a sample view of the system in a preliminary state, and Fig. 5b and Fig. 5c are sample views of the system at different angles when the infusion bottle and the vial are fixedly connected to the liquid transfer connector.

[0084] Application Example 1 The above has already described in detail the performance advantages of the liquid drug transfer device and liquid drug transfer system of the present invention compared to the prior art. In order to further verify the technical effects, application experiments are currently being carried out using actual products.

[0085] 1. Experiment location Zhanjiang Kenliyuan Medical Supplies Co., Ltd. Product Research and Development Laboratory.

[0086] 2. Experimental subjects The drug solution transfer system shown in FIG. 5 was adopted as the experimental sample, in which the drug solution transfer device was as shown in FIG. 3, and the specifications of the first and second syringes were 20 mL.

[0087] Add 10 mL of 10 g / L aqueous solution of sodium fluoride to the vial and seal it with an aluminum cap chlorinated butyl rubber stopper to designate it as vial A. Take another empty vial and seal it similarly with an aluminum cap chlorinated butyl rubber stopper to designate it as vial B as a spare.

[0088] 3. Experimental method 1) The first piston rod of the double-chamber syringe was pulled back until the volume of the front cavity of the first syringe barrel was greater than 10 mL. To perform this gas storage operation, the double-chamber syringe was separated from the dispensing needle assembly, and after storing the gas, it was re-fixed and connected to the dispensing needle assembly.

[0089] 2) The second sleeve of the liquid transfer connector A is fitted onto the bolt mouth of the vial bottle A and fixed to it using a buckle claw. Then, the sheath of the drug liquid transfer device is held and aligned, and the first sleeve of the liquid transfer connector A is inserted and rotated to fix it. At this time, the front end face of the sealing member and the back mouth of the vial bottle A abut within the sleeve.

[0090] 3) The syringe barrel of the drug solution transfer device was held and pushed forward, and as the spring compressed, the dispensing needle penetrated the sealing member and pierced the vial A. After completely piercing, the syringe barrel was rotated, and the needle seal assembly and the needle hub were fixed with the stopper.

[0091] 4) The second piston rod of the double-chamber syringe is pulled, and the solution in vial A is extracted into the second syringe barrel through the sealed passage II. At this time, negative pressure is generated in vial A, and under the action of the pressure difference between the inside and outside, the first piston rod moves forward, replenishing the air reserved in the first syringe barrel into vial A until the air pressures inside and outside the vial A are equilibrated.

[0092] 5) After the extraction of the solution is completed, the syringe barrel is rotated in the reverse direction to release the stopper fixing between the needle seal assembly and the needle hub, and under the assistance of the elastic potential energy of the spring, the double chamber syringe and the dispensing needle assembly are moved backward until the dispensing needle is reset, exiting from vial A and being resealed by the sealing member.

[0093] 6) The sheath of the drug solution transfer device was twisted to release the fixed connection between the drug solution transfer device and the liquid transfer connector A, and then the drug solution transfer device was pulled out from the liquid transfer connector A.

[0094] 7) The second sleeve of the liquid transfer connector B is fitted onto the bolt mouth of the vial bottle B and fixed to it using a buckle claw. Then, the sheath of the drug liquid transfer device is held and aligned, and inserted into the first sleeve of the liquid transfer connector B, and rotated to fix it. At this time, the front end face of the sealing member and the glue mouth of the vial bottle B abut within the sleeve.

[0095] 8) The syringe barrel of the drug solution transfer device was held and pushed forward, and as the spring compressed, the dispensing needle penetrated the sealing member and pierced vial B. After completely piercing, the syringe barrel was rotated and the needle seal assembly and needle hub were fixed with the stopper.

[0096] 9) The second piston rod of the double-chamber syringe is pressed, and the solution is injected from the second syringe barrel through sealed passage II into vial B. At this time, positive pressure is generated in vial B, and the air therein automatically flows into the first syringe barrel through sealed passage I, causing the first piston rod to retract.

[0097] 10) After the solution was completely injected into vial B, refer to steps (5) and (6) to reset the dispensing needle and pull out the drug transfer connector from the transfer connector B.

[0098] A three-purpose ultraviolet analyzer (model: ZF-1) was used to detect the liquid transport system at different stages in the above process. The specific method was to place the liquid transport system on the operation table of the three-purpose ultraviolet analyzer, turn on the instrument to irradiate ultraviolet light onto it, and observe whether fluorescent spots appeared in specific areas.

[0099] 4. Experimental results The detection results obtained using the triple-purpose ultraviolet analyzer are shown in FIG.

[0100] Figure 6a is a fluorescent display diagram after the drug liquid transfer device is fixed and connected to the vial bottle A through the liquid transfer connector A, and the initial fluorescent state at the time of connection is presented. Note: Since it is only to present the initial fluorescent state, no gas was stored in the first syringe beforehand.

[0101] Figure 6b is a fluorescence display diagram of the drug transfer system after the above steps 1) to 6) are completed. As can be seen, there is no fluorescence at the contact point between vial bottle A and the drug transfer device. This indicates that the extraction process of the fluorescent sodium aqueous solution is completed in a completely sealed state, the sealing performance of the drug transfer system is very good, and there is no leakage at all at the contact point between vial bottle A and the drug transfer device.

[0102] FIG. 6c is a system fluorescence display diagram after injecting some fluorescent sodium aqueous solution into vial B during the process of performing the above-mentioned step 9), pausing the operation, and separating the liquid transfer device and the liquid transfer connector B. As can be seen, there is no fluorescence at the contact site between vial B and the liquid transfer device, and no fluorescence phenomenon appears on the sample appearance of the liquid transfer device, except for a small amount of transmissive fluorescence caused by the adhesion residue inside the second syringe filled with fluorescent sodium aqueous solution and the liquid channel of the solution. These phenomena indicate that the liquid transfer system of the present invention has very good sealing performance, and both sealing passages I and II play their respective roles and do not interfere with each other.

[0103] Furthermore, when using the drug solution transfer system of the present invention, it is possible to ensure that the pressure inside and outside the vial is always equal, so that the suction and injection of the solution is very smooth and there is no problem of having to overcome the pressure difference between the inside and outside of the vial, which would make the operation more difficult.

[0104] Application Example 2 In order to further verify the sealing performance during the preparation and transfer of the liquid medicine of the liquid medicine transfer device and the liquid medicine transfer system of the present invention, an application experiment was carried out using an odorous solution in combination.

[0105] 1. Experiment location Zhanjiang Kenliyuan Medical Supplies Co., Ltd. Product Research and Development Laboratory.

[0106] 2. Experimental subjects The drug solution transfer system shown in FIG. 5 was adopted as the experimental sample, in which the drug solution transfer device was as shown in FIG. 3, and the specifications of the first and second syringes were 20 mL.

[0107] In a laboratory ventilation room, 10 mL of a 0.1 g / L garlic odorant solution was added to a vial and sealed with an aluminum cap chlorinated butyl rubber stopper. The outer surface was then thoroughly washed and dried to an odorless state, and this was designated vial A. Another empty vial was taken and similarly sealed with an aluminum cap chlorinated butyl rubber stopper, designated vial B, and kept as a spare.

[0108] 3. Experimental method In an independent and sealed laboratory with an area of ​​about 12 square meters, referring to the steps of Application Example 1, the garlic odorant solution in vial A was transferred entirely to vial B.

[0109] After that, three men and three women between the ages of 26 and 43, who were healthy and had a normal sense of smell, were selected to enter the laboratory and stay there for 30 seconds, and then provided feedback on whether or not they could smell the corresponding odor and its intensity.

[0110] 4. Experimental results According to the feedback results, out of the six test subjects, three males and two females said they did not smell anything, and one female said that there seemed to be a slight odor in the air, but the type of odor could not be determined. This result further demonstrated the perfect sealing effect of the drug liquid delivery system of the present invention in the drug liquid preparation and delivery process, which can minimize the risk of drug leakage, and the sealing effect is very good.

[0111] The above embodiments mainly describe the basic principle, main features and advantages of the present invention. Those skilled in the art should understand that the present application is not limited to the above embodiments, and that the above embodiments and descriptions in the specification are merely illustrative of the principles of the present invention, and that there are various changes and modifications to the present invention, all of which are within the scope of the present invention that claims protection, provided that they do not deviate from the spirit and scope of the present invention. [Explanation of symbols]

[0112] 10, double chamber syringe, 11, first syringe barrel, 12, first piston rod, 13, first coupling, 14, second syringe barrel, 15, second piston rod, 16, second coupling, 20, dispensing needle assembly, 21, dispensing needle, 211, inner column channel, 212, side ring channel, 22, needle hub, 221, first connecting hole, 222, first channel, 223, second connecting hole, 224, second channel, 23, needle threader, 30, needle seal assembly, 31, sheath, 32, sealing member, 33, elastic member, 34, inner sleeve, 40, transfer coupling, 41, first sleeve, 42, second sleeve, 43, buckle claw, 44, release arm, 45, engagement groove.

Claims

1. A double-chamber internal circulation sealed liquid medicine transfer device including a double-chamber syringe (10), a dispensing needle (21) assembly (20), and a needle seal assembly (30), The double-chamber syringe (10) is composed of a first syringe barrel (11), a first piston rod (12) that can slide back and forth along an internal cavity in the first syringe barrel (11), a second syringe barrel (14), and a second piston rod (15) that can slide back and forth along an internal cavity in the second syringe barrel (14), where the first syringe barrel (11) and the second syringe barrel (14) are arranged side by side, in the same direction, and fixedly installed in a manner that their front ends are flush with each other, a first joint (13) is installed on the front end surface of the first syringe barrel (11), and a second joint (16) is installed on the front end surface of the second syringe barrel (14); The dispensing needle (21) assembly (20) includes a dispensing needle (21) and a needle hub (22), the dispensing needle (21) being fixedly connected to the needle hub (22) in a manner that the rear end of the dispensing needle (21) is embedded in the front end of the needle hub (22), wherein: The needle hub (22) has a first connecting hole (221) at the rear end thereof, which is adapted to fit the first joint (13), and a second connecting hole (223) at the rear end thereof, and the needle hub (22) has a first channel (222) and a second channel (224) at the rear end thereof, which are connected to the first connecting hole (221) and the second connecting hole (223), respectively, and which are independent of each other; The dispensing needle (21) has a double-layered columnar structure, and has an inner column channel (211) and a side ring channel (212), where the inner column channel (211) communicates with a first channel (222), and the side ring channel (212) communicates with a second channel (224); By embedding the first coupling (13) and the second coupling (16) into the first connecting hole (221) and the second connecting hole (223), respectively, the dispensing needle (21) assembly (20) and the double-chamber syringe (10) achieve a fixed and sealed connection; The needle seal assembly (30) includes a sheath (31) disposed coaxially with the dispensing needle (21), a sealing member (32), and an elastic member (33), wherein: The sheath (31) is a hollow cylindrical structure that is open at the front and rear, and is axially movably mounted on the front end of the needle hub (22). The sealing member (32) is made of an elastic material and is fixedly installed within the front end barrel of the sheath (31); The central axis of the sealing member (32) is provided with a hole tube through which the dispensing needle (21) passes, and the inner diameter of the hole tube is smaller than the outer diameter of the dispensing needle (21); The elastic member (33) is disposed between the sealing member (32) and the needle hub (22), and depending on the needle hub (22), the elastic member (33) provides an axial elastic support to the sealing member (32) at the front end; In a non-pressurized state, the elastic member (33) extends in the axial direction, and the sheath (31) shields the preparation needle (21) inside the sheath (31). At the same time, due to the elastic action of the elastic material, the sealing member (32) tightly encloses the front end of the preparation needle (21) and seals the front end channel mouths of the inner column channel (211) and the side ring channel (212) inside. In a pressurized state, the elastic member (33) is compressed in the axial direction, and the front end of the dispensing needle (21), including the inner column channel (211) and the front end channel port of the side ring channel (212), can exit from the sheath (31) through the hole tube of the sealing member (32).

2. 2. The sealed liquid medicine transfer device according to claim 1, wherein the first syringe barrel (11) and the second syringe barrel (14) have the same size specifications.

3. 2. The closed type liquid medicine transfer device according to claim 1, wherein the first joint (13) and the second joint (16) are installed in a close proximity manner.

4. The outer walls of the first joint (13) and the second joint (16) are tapered surfaces, and at least one annular boss is provided on the tapered surfaces; Accordingly, the shapes of the first connecting hole (221) and the second connecting hole (223) installed at the rear end of the needle hub (22) respectively match the tapered surfaces of the corresponding joints, and an annular groove corresponding to the annular boss is installed on the hole wall.

5. 2. The closed liquid medicine transfer device according to claim 1, wherein the dispensing needle (21) is composed of an inner needle tube and an outer needle tube, the inner needle tube is inserted into the outer needle tube, and both ends extend outside the outer needle tube, at this time, the inner column channel (211) is formed by the inner cavity of the inner needle tube, and the side ring channel (212) is formed by the cavity between the outer needle tube and the inner needle tube.

6. The sealed liquid medicine transfer device according to claim 5, characterized in that the inner needle tube and the outer needle tube are independent of each other or are integrally molded and fixedly connected to each other, and if the latter type is selected, preferably the front end of the outer needle tube is hermetically fixedly connected to the front end side wall of the inner needle tube.

7. 7. The sealed liquid medicine transfer device according to claim 6, wherein the front end of the inner needle tube is provided with an oblique opening, or the front end of the inner needle tube is a tip end with a side opening, and the front end side wall of the outer needle tube is provided with a side opening.

8. A mounting groove is provided at the front end of the needle hub (22), and a needle threading base (23) having an outer shape matching the mounting groove is mounted in the mounting groove; The front end openings of the first channel (222) and the second channel (224) are both located at the bottom of the mounting groove, and the front end opening of the first channel (222) is coaxial with the dispensing needle (21); The inside of the needle threading table (23) is provided with a through hole tube that penetrates from front to back at a position corresponding to the axis of the preparation needle (21), and is composed of a needle threading hole located at the front and a fixing hole located at the rear. The needle threading hole is trumpet-shaped, and the inner diameter of the fixing hole gradually decreases from front to rear. The inner diameter of the fixing hole matches the outer diameter of the outer needle tube; A connecting groove is provided on the rear end surface of the needle threading base (23), and both ends of the connecting groove are connected to the second channel (224) and the fixing hole, respectively; 2. The closed type liquid medicine transfer device according to claim 1, wherein the rear end of the inner needle tube of the dispensing needle (21) passes through the needle threading base (23) and is fixed in the first channel (222) in an embedded manner, and the rear end of the outer needle tube is fixed in the fixing hole of the needle threading base (23) in an embedded manner.

9. 9. The closed liquid medicine transfer device according to claim 8, characterized in that the first channel (222) in the needle hub (22) is arranged in a manner coaxial with the dispensing needle (21), and the second channel (224) is arranged parallel to one side of the first channel (222).

10. 9. The sealed liquid medicine transfer device according to claim 8, wherein the cross section of the needle threader (23) is not circular and remains unchanged along the axial direction.

11. 11. The sealed liquid transfer device according to claim 1, wherein after the dispensing needle assembly (20) and the double-chamber syringe (10) are fixed and hermetically connected, the inner column channel (211), the first channel (222), the first connecting hole (221) and the first syringe barrel (11) communicate with each other from front to rear to form a sealed passage I, the side ring channel (212), the second channel (224), the second connecting hole (223) and the second syringe barrel (14) communicate with each other from front to rear to form a sealed passage II, and the sealed passages I and II are independent of each other.

12. The needle seal assembly (30) includes a coaxially disposed sheath (31), a sealing member (32), a resilient member (33), and an inner sleeve (34), wherein: the front end of the sheath (31) has a smaller radial size and forms a composite tubular structure consisting of a first tubular segment having a relatively small inner diameter and a second tubular segment having a relatively large inner diameter; the sealing member (32) is designed as an inverted T-shaped structure in cross section, with a front diameter corresponding to the inner diameter of the first cylindrical segment and a rear diameter corresponding to the inner diameter of the second cylindrical segment, so that the sealing member (32) can completely fill the inner cavity of the first cylindrical segment and at the same time fill at least a part of the inner cavity of the second cylindrical segment; The inner diameter of the inner sleeve (34) corresponds to the outer diameter of the needle hub (22), the outer diameter of the inner sleeve (34) corresponds to the inner diameter of the second cylindrical segment of the sheath (31), its front end face is sealed, and a through hole is provided in the center of the end face for the dispensing needle (21) to pass through, the inner sleeve (34) is fixedly connected in the second cylindrical segment of the sheath (31), and its front end face abuts against the rear end face of the sealing member (32); 2. The sealed liquid medicine transfer device of claim 1, wherein the elastic member (33) is installed within the inner sleeve (34) and both ends abut against the inner surface of the front end of the inner sleeve (34) and the front end surface of the needle hub (22), respectively.

13. The sealed drug liquid transfer device of claim 12, characterized in that a buckle is provided on the outer wall of the inner sleeve (34), and a corresponding locking hole is provided on the second cylindrical segment of the sheath (31), and the cooperation of the buckle and the locking hole realizes a fixed connection between the sheath (31) and the inner sleeve (34) when the inner sleeve (34) is inserted into the sheath (31).

14. The sealed liquid drug transfer device according to claim 12 or 13, characterized in that an annular boss is provided at the rear end opening of the inner sleeve (34) in a radially outward manner, and when the front end face of the inner sleeve (34) abuts against the rear end face of the sealing member (32), the annular boss at the rear end is exposed from the sheath (31) and abuts against the rear end of the sheath (31).

15. The sealed liquid medicine transfer device according to any one of claims 12 to 14, characterized in that a buckle structure is provided on the inner surface of the front end of the inner sleeve (34) and the front end surface of the needle hub (22), thereby realizing a fixed connection with the elastic member (33).

16. 15. The sealed drug solution transfer device according to claim 12, wherein an L-shaped groove consisting of an axial groove and a lateral groove is provided on the side of the needle hub (22), and a slide table is provided radially inward at the rear end of the inner sleeve (34), and the slide table is embedded in the L-shaped groove and is slidable along the groove.

17. 2. The sealed liquid medicine transfer device according to claim 1, wherein the sealing member (32) is made of an elastic material, preferably any one of rubber, silica gel, and synthetic rubber.

18. 2. The sealed liquid drug transporter according to claim 1, wherein a front end surface of the sealing member (32) protrudes outward beyond a front end surface of the sheath (31).

19. 2. The sealed liquid drug transfer device according to claim 1, wherein the elastic member (33) is an elastic folded tube or a spring.

20. The sealed liquid drug transfer device according to claim 1, characterized in that two engaging platforms that are convex radially outward are symmetrically installed on the outer wall of the front end of the sheath (31) to facilitate fixed connection with the liquid transfer connector (40).

21. The sealed liquid drug transfer device according to claim 1 , further comprising a protective cap.

22. A closed drug transfer system comprising: The device includes a sealed liquid medicine transfer device according to any one of claims 1 to 21, and a liquid transfer connector (40) for fixedly connecting the liquid medicine transfer device to a drug container, A sealed drug liquid transfer system, in which one end of the liquid transfer connector (40) is used for removably fixing and connecting a drug container, and the other end is used for removably fixing and connecting a drug liquid transfer device, and when fixedly connected, the front end face of the sealing member abuts against the container mouth of the drug container.

23. The closed liquid medicine transfer system of claim 22, characterized in that the liquid transfer connector (40) includes a first sleeve (41) and a second sleeve (42) which are coaxially and connected to each other, the first sleeve (41) is used to be removably fitted to the front end of the sheath (31) of the liquid medicine transfer device, and the second sleeve (42) is used to be removably fitted to the container mouth of the drug container, and when fixedly connected, the front end face of the sealing member and the container mouth of the drug container maintain stable abutment within the sleeve.

24. The closed liquid medicine transfer system of claim 23, characterized in that the second sleeve (42) has symmetrically arranged buckle claws (43) extending axially forward on its outer edge, and a rear end of each buckle claw (43) has a rearward extending release arm (44) installed, and the second sleeve (42) is fixed to the container mouth via the buckle claws (43) and detached from the container mouth via the release arms (44).

25. The sealed drug solution transfer system of claim 23, characterized in that two engagement grooves (45) are symmetrically installed on the inner wall of the first sleeve (41), the engagement groove (45) being an L-shaped structure consisting of an axial groove and a lateral groove, and correspondingly, two engagement platforms that are convex radially outward are symmetrically installed on the front end outer wall of the sheath (31).

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