Devices for aortic repair and related systems and methods

Abstract

Aortic repair devices and related systems and methods are disclosed herein. An aortic repair device configured according to embodiments of the present technology can include a base member configured to be implanted in the aorta proximate a diseased portion of the aorta (e.g., aneurysm or dissection). The base member can direct blood flow through the diseased portion of the aorta and perfuse a portion of the aorta distal to the diseased portion and / or various branch vessels. In some embodiments, one or more spanning members or other implants can be coupled (e.g., docked) to the base member during the same or separate endovascular procedure to provide additional flow paths through the diseased portion.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application No. 63 / 316,896, entitled "DEVICES FOR AORTIC REPAIR, AND ASSOCIATED SYSTEMS AND METHODS," filed March 4, 2022, U.S. Provisional Patent Application No. 63 / 425,600, entitled "DEVICES FOR AORTIC REPAIR, AND ASSOCIATED SYSTEMS AND METHODS," filed November 15, 2022, and U.S. Provisional Patent Application No. 63 / 437,916, entitled "DEVICES FOR AORTIC REPAIR, AND ASSOCIATED SYSTEMS AND METHODS," filed January 9, 2023, each of which is incorporated by reference in its entirety herein.

[0002] The present technology relates to devices, systems, and methods for repairing diseased aortas, and more particularly, to devices configured to be implanted at least partially within the proximal aorta to treat aneurysms and dissections in the ascending aorta and / or aortic arch. [Background technology]

[0003] Aneurysms, dissections, penetrating ulcers, intramural hematomas, and / or transections can occur in blood vessels, most typically in the aorta and peripheral arteries. Affected regions of the aorta can extend into areas with vessel branching points or segments of the aorta from which smaller "branch" arteries extend.

[0004] Diseased regions of the aorta and other blood vessels can be bypassed by stent grafts placed inside the vessel to span the diseased region. The stent graft can effectively seal the diseased region from further exposure to blood flow and prevent aneurysms, dissections, or other types of diseased regions from worsening. However, using stent grafts to internally bypass diseased regions of blood vessels is not without challenges. In particular, care must be taken to ensure that the stent graft does not cover or occlude critical branch vessels, yet the stent graft must adequately seal against healthy regions of the vessel wall and remain open to provide a flow conduit for blood to flow past the diseased region. Summary of the Invention

[0005] Many aspects of the present disclosure can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure. [Brief description of the drawings]

[0006] [Figure 1A] FIG. 1 is a side view of a diseased aorta and surrounding anatomical structures into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 1B] FIG. 1 is a side view of a diseased aorta and surrounding anatomical structures into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 2A] FIG. 1 is a side cross-sectional view of a diseased aorta into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 2B] FIG. 1 is a side cross-sectional view of a diseased aorta into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 2C] FIG. 1 is a side cross-sectional view of a diseased aorta into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 2D]FIG. 1 is a side cross-sectional view of a diseased aorta into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 3A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 3B] FIG. 14 is a side perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 3C] 3C is a cross-sectional view of the aortic repair device of FIGS. 3A and 3B taken along line 3C-3C of FIG. 3A in accordance with an embodiment of the present technology. [Figure 3D] FIG. 3C is a side view of the aortic repair device of FIGS. 3A-3C implanted in the aorta in accordance with an embodiment of the present technology. [Figure 4A] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 4B] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 5A] FIG. 5 is a side view of an aortic repair device 500 in accordance with an embodiment of the present technology. [Figure 5B] 5B is a cross-sectional view of the aortic repair device of FIG. 5A taken along line 5B-5B of FIG. 5A in accordance with an embodiment of the present technology. [Figure 5C] 5B is a cross-sectional view of the aortic repair device of FIG. 5A taken along line 5B-5B of FIG. 5A in accordance with an embodiment of the present technology. [Figure 6A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 6B] 6B is a cross-sectional view of the aortic repair device of FIG. 6A taken along line 6B-6B of FIG. 6A in accordance with an embodiment of the present technology. [Figure 7A] FIG. 13 is a distal-facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 7B] FIG. 13 is a distal-facing end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 7C]FIG. 7C is a distal-facing end view of the aortic repair device of FIGS. 7A and 7B being expanded in the aorta in accordance with an embodiment of the present technology. [Figure 8A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 8B] FIG. 14 is a side perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 8C] FIG. 13 is a proximal-facing perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 8D] FIG. 13 is a proximal facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 8E] FIG. 13 is a distal-facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 8F] 8F-8F is a cross-sectional view of the aortic repair device of FIGS. 8A-8E taken along line 8F-8F of FIG. 8B. [Figure 8G] 8F-8F is a cross-sectional view of the aortic repair device of FIGS. 8A-8E taken along line 8F-8F of FIG. 8B. [Figure 8H] FIG. 8F is a cross-sectional view of the aortic repair device of FIGS. 8A-8G taken along line 8F-8F of FIG. 8B with a spanning member deployed within the lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 9A] FIG. 8H is a cross-sectional view of the aortic repair device of FIG. 8H during a first delivery stage and a second delivery stage in accordance with an embodiment of the present technology. [Figure 9B] FIG. 8H is a cross-sectional view of the aortic repair device of FIG. 8H during a first delivery stage and a second delivery stage in accordance with an embodiment of the present technology. [Figure 10A] FIG. 13 is a distal-facing end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 10B] FIG. 13 is a distal-facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 10C]FIG. 10C is a distal-facing end view of the aortic repair device of FIGS. 10A and 10B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 10D] FIG. 10C is a perspective distal end view of the aortic repair device of FIGS. 10A and 10B with a spanning member placed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 11A] 1 is a cross-sectional view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 11B] FIG. 11B is a cross-sectional side view of a stent of the spanning member of the aortic repair device of FIG. 11A in accordance with an embodiment of the present technology. [Figure 12A] 1 is a cross-sectional view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 12B] FIG. 12B is a cross-sectional side view of a stent of the spanning member of the aortic repair device of FIG. 12A in accordance with an embodiment of the present technology. [Figure 13A] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 13B] FIG. 13 is a distal-facing perspective end view of a spanning member in accordance with an embodiment of the present technology. [Figure 13C] FIG. 13 is another distal-facing perspective end view of a spanning member in accordance with an embodiment of the present technology. [Figure 14A] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 14B] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 14C] FIG. 14C is a perspective distal end view of an aortic repair device including the spanning member of FIGS. 14A and 14B disposed within a base member in accordance with an embodiment of the present technology. [Figure 14D] FIG. 14C is an enlarged, distal-facing perspective end view of an aortic repair device including the spanning member of FIGS. 14A and 14B positioned within a base member in accordance with an embodiment of the present technology. [Figure 15A] FIG. 13 is a side view of a spanning member in accordance with an embodiment of the present technology; [Figure 15B] FIG. 13 is a distal-facing end view of a spanning member in accordance with an embodiment of the present technology. [Figure 15C] FIG. 15C is a distal end view of an aortic repair device including the spanning member of FIGS. 15A and 15B in accordance with an embodiment of the present technology. [Figure 15D] 15A-15C when undergoing blood flow and having graft material attached inside multiple stents in accordance with an embodiment of the present technology. FIG. [Figure 15E] 15A-15C when undergoing blood flow and having graft material attached to the outside of a number of stents in accordance with an embodiment of the present technology. FIG. [Figure 16A] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 16B] FIG. 13 is a perspective end view of a spanning member in accordance with an embodiment of the present technology; [Figure 17A] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 17B] 1 is a side cross-sectional view of a spanning member in accordance with an embodiment of the present technology; [Figure 17C] FIG. 13 is a perspective end view of a spanning member in accordance with an embodiment of the present technology; [Figure 18A] 13A-13D are end views of a spanning member in a constrained and expanded configuration in accordance with an embodiment of the present technology. [Figure 18B] FIG. 18B is a distal-facing end view of an aortic repair device 1800 including the spanning member of FIG. 18A in accordance with an embodiment of the present technology. [Figure 19] FIG. 13 is a distal-facing end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 20A] FIG. 13 is an enlarged side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 20B] FIG. 13 is a distal-facing perspective end view of a spanning member in accordance with an embodiment of the present technology. [Figure 21] 1 is a side perspective view of a spanning member constructed in accordance with an embodiment of the present technology; FIG. [Figure 22A] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 22B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Diagram 23] 22A and 22B in accordance with an embodiment of the present technology. FIG. [Figure 24] 1A-1D are side views of the aorta illustrating aspects of an aortic repair device delivery procedure. [Figure 25A] 1A-1D are side perspective views of various aortic repair devices configured in accordance with embodiments of the present technology. [Figure 25B] 1A-1D are side perspective views of various aortic repair devices configured in accordance with embodiments of the present technology. [Figure 25C] 1A-1D are side perspective views of various aortic repair devices configured in accordance with embodiments of the present technology. [Figure 25D] 1A-1D are side perspective views of various aortic repair devices configured in accordance with embodiments of the present technology. [Figure 25E] 1A-1D are side perspective views of various aortic repair devices configured in accordance with embodiments of the present technology. [Figure 26A] FIG. 13 is an enlarged side view of a portion of an aortic repair device in a first position in accordance with an embodiment of the present technology. [Figure 26B] FIG. 13 is an enlarged side view of a portion of an aortic repair device in a second position in accordance with an embodiment of the present technology. [Figure 27A] FIG. 1 is a side perspective view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 27B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 27C]FIG. 27C is a perspective view of a first stent component of the aortic repair device of FIGS. 27A and 27B in accordance with an embodiment of the present technology. [Figure 27D] FIG. 27C shows the aortic repair device of FIGS. 27A and 27B implanted in the aorta and conforming to the wall of the ascending aorta proximal to the aortic arch in accordance with an embodiment of the present technology. [Figure 28A] FIG. 1 is a perspective view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 28B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 29A] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 29B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 30A] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 30B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 30C] FIG. 30C is a perspective end view of a secondary lumen stent component of the aortic repair device of FIGS. 30A and 30B in accordance with an embodiment of the present technology. [Figure 30D] FIG. 30C is an end view of the secondary lumen stent component of the aortic repair device of FIGS. 30A and 30B in accordance with an embodiment of the present technology. [Figure 30E] FIG. 30C is a perspective end view of the aortic repair device of FIGS. 30A and 30B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 30F] FIG. 30C is a perspective end view of the aortic repair device of FIGS. 30A and 30B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 31A] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 31B] FIG. 1 is a perspective end view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 31C] FIG. 31C is a perspective end view of a secondary lumen stent of the aortic repair device of FIGS. 31A and 31B in accordance with an embodiment of the present technology. [Figure 31D] FIG. 31C is an end view of a secondary lumen stent of the aortic repair device of FIGS. 31A and 31B in accordance with an embodiment of the present technology. [Figure 31E] FIG. 31C is a perspective end view of the aortic repair device of FIGS. 31A and 31B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Fig. 31F] FIG. 31C is a perspective end view of the aortic repair device of FIGS. 31A and 31B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Figure 31G] FIG. 31C is a perspective end view of the aortic repair device of FIGS. 31A and 31B with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Fig. 31H] 31A and 31B are perspective end views of the aortic repair device, illustrating increased radial compression of the aortic repair device in accordance with an embodiment of the present technology. [Fig. 31I] 31A and 31B are perspective end views of the aortic repair device, illustrating increased radial compression of the aortic repair device in accordance with an embodiment of the present technology. [Figure 31J] 31A and 31B are perspective end views of the aortic repair device, illustrating increased radial compression of the aortic repair device in accordance with an embodiment of the present technology. [Figure 31K] 31A and 31B are perspective end views of the aortic repair device, illustrating increased radial compression of the aortic repair device in accordance with an embodiment of the present technology. [Figure 31L] 31A and 31B are perspective end views of the aortic repair device, illustrating increased radial compression of the aortic repair device in accordance with an embodiment of the present technology. [Figure 32A] FIG. 13 is a perspective end view of an aortic repair device deployed within a lumen in accordance with an embodiment of the present technology. [Figure 32B] FIG. 32B is an end view of the secondary lumen stent component of the aortic repair device of FIG. 32A in accordance with an embodiment of the present technology. [Figure 32C] FIG. 32B is a perspective end view of the aortic repair device of FIG. 32A with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Fig. 32D] FIG. 32B is a perspective end view of the aortic repair device of FIG. 32A with a spanning member deployed within the primary lumen of the aortic repair device in accordance with an embodiment of the present technology. [Diagram 33] 1 is a cross-sectional view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 34A] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 34B] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally compressed position in accordance with an embodiment of the present technology. [Figure 35A] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 35B] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally compressed position in accordance with an embodiment of the present technology. [Figure 36A] 13A-13D are side perspective views of an aortic repair device in a longitudinally elongated position from different circumferential views in accordance with an embodiment of the present technology. [Figure 36B] 13A-13D are side perspective views of an aortic repair device in a longitudinally elongated position from different circumferential views in accordance with an embodiment of the present technology. [Figure 36C] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally compressed position in accordance with an embodiment of the present technology. [Figure 36D]FIG. 36C is a plan view of a first stent and a second stent of the aortic repair device in accordance with an embodiment of the present technology. [Figure 37A] FIG. 1 is a side perspective view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 37B] FIG. 37B is a plan view of a first stent and a second stent of the aortic repair device of FIG. 37A configured in accordance with an embodiment of the present technology. [Figure 38] FIG. 13 is a plan view of a first stent and a second stent of an aortic repair device in accordance with an additional embodiment of the present technology. [Figure 39A] FIG. 13 is a side view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 39B] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 39C] FIG. 39C is a side perspective view of the aortic repair device of FIGS. 39A and 39B in a longitudinally compressed position in accordance with an embodiment of the present technology. [Figure 40A] FIG. 13 is a side view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 40B] FIG. 13 is a side perspective view of an aortic repair device in a longitudinally elongated position in accordance with an embodiment of the present technology. [Figure 40C] FIG. 40C is a side perspective view of the aortic repair device of FIGS. 40A and 40B in a longitudinally compressed position in accordance with an embodiment of the present technology. [Figure 40D] FIG. 39A is a side view of the aortic repair device of FIGS. 39A-39C or 40A-40C implanted in the aorta in accordance with an embodiment of the present technology. [Figure 41A] 1 is a side view of a spanning member configured in accordance with an embodiment of the present technology; [Figure 41B] 1 is a side view of a spanning member configured in accordance with an embodiment of the present technology; [Figure 41C]FIG. 41C is a close-up view of a portion of the spanning member shown in FIG. 41B in accordance with an embodiment of the present technology. [Figure 41D] 1A-1C are enlarged views of proximal and distal end portions of components of an aortic repair device in accordance with an embodiment of the present technology. [Figure 41E] 1A-1C are enlarged views of proximal and distal end portions of components of an aortic repair device in accordance with an embodiment of the present technology. [Fig.41F] 1A-1C are enlarged views of proximal and distal end portions of components of an aortic repair device in accordance with an embodiment of the present technology. [Figure 42A] FIG. 1 is an anterior view of the aorta and surrounding anatomical structures into which an aortic repair device may be implanted in accordance with an embodiment of the present technology. [Figure 42B] 1A-1D are side views of various aortic repair devices in accordance with embodiments of the present technology. [Figure 42C] 1A-1D are side views of various aortic repair devices in accordance with embodiments of the present technology. [Fig.42D] 1A-1D are side views of various aortic repair devices in accordance with embodiments of the present technology. [Figure 43A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 43B] FIG. 14 is a side perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 43C] FIG. 13 is a distal-facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 43D] FIG. 43C is a side view of the aortic repair device of FIGS. 43A-43C implanted in the aorta in accordance with an embodiment of the present technology. [Figure 44A] FIG. 13 is a side view of a spanning member in accordance with an embodiment of the present technology; [Figure 44B] FIG. 13 is a side perspective view of a spanning member in accordance with an embodiment of the present technology; [Figure 44C] FIG. 13 is a distal-facing perspective end view of a spanning member in accordance with an embodiment of the present technology. [Fig.44D]44A-44C coupled to the base member of FIGS. 43A-43D in accordance with an embodiment of the present technology. FIG. [Figure 44E] 44A-44C coupled to the base member of FIGS. 43A-43D in accordance with an embodiment of the present technology. FIG. [Figure 45A] FIG. 13 is an enlarged side view of a spanning member in accordance with an embodiment of the present technology. [Figure 45B] FIG. 45B is a side view of an aortic repair device including the spanning member of FIG. 45A coupled to the base member of FIGS. 43A-43D in accordance with an embodiment of the present technology. [Figure 45C] FIG. 45C is a proximal-facing perspective view of the primary leg of the base member of FIG. 45B in accordance with an embodiment of the present technology. [Figure 45D] FIG. 45B is an enlarged side perspective view of a proximal end portion of the spanning member of FIG. 45A in accordance with an embodiment of the present technology. [Figure 45E] FIG. 45D is a proximal-facing perspective view of the spanning member of FIG. 45D coupled to the primary leg of the base member of FIG. 45C in accordance with an embodiment of the present technology. [Figure 46] FIG. 13 is a side perspective view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Figure 47A] FIG. 13 is a distal-facing perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 47B] FIG. 13 is a proximal facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 47C] FIG. 47C is a side perspective view of a base member of the aortic repair device of FIGS. 47A and 47B in accordance with an embodiment of the present technology. [Figure 47D] FIG. 47C is a perspective distal end view of a base member of the aortic repair device of FIGS. 47A and 47B in accordance with an embodiment of the present technology. [Figure 47E] FIG. 47C and 47D are cross-sectional views of a base member of the aortic repair device in accordance with an embodiment of the present technology. [Fig.47F]FIG. 47C and 47D are cross-sectional views of a base member of the aortic repair device in accordance with an embodiment of the present technology. [Figure 47G] FIG. 47C and 47D are cross-sectional views of a base member of the aortic repair device in accordance with an embodiment of the present technology. [Figure 48-1] Figure 48A is an isometric side view of an aortic repair device in accordance with an embodiment of the present technology. Figures 48E, F, G, and H are cross-sectional views of an aortic repair device as shown in Figure 48A in accordance with an embodiment of the present technology. [Figure 48-2] 48B, 48C, and 48D are side perspective, enlarged, side, and distal-facing perspective end views of an aortic repair device in accordance with an embodiment of the present technology. [Figure 49] FIG. 48C is an isometric side view of a spanning member configured to couple to the base member of the aortic repair device of FIGS. 48A-H in accordance with an embodiment of the present technology. [Figure 50] 49 is a side view of an aortic repair device including a pair of base members of FIGS. 48A-48H and the spanning member of FIG. 49 implanted in the aorta in accordance with an embodiment of the present technology. [Figure 51A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 51B] FIG. 14 is a side perspective view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 51C] FIG. 13 is a perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 51D] FIG. 13 is a distal-facing perspective end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 51E] FIG. 51C is a distal-facing end view of the aortic repair device of FIGS. 51A-51C in accordance with an additional embodiment of the present technology. [Fig. 51F] FIG. 51A-51C are side views of the aortic repair device in accordance with an additional embodiment of the present technology. [Figure 52A]51D during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 52B] 51D during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 52C] 51D during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 53A] FIG. 51C is an enlarged side view of the septum and stent of the aortic repair device in accordance with an embodiment of the present technology. [Figure 53B] FIG. 51C is a side perspective view of the septum and stent of the aortic repair device of FIGS. 51A-51C in accordance with an embodiment of the present technology. [Figure 54A] FIG. 51C is an enlarged side view of the septum and stent of the aortic repair device in accordance with an embodiment of the present technology. [Figure 54B] FIG. 51C is a perspective top view of the septum and stent of the aortic repair device in accordance with an embodiment of the present technology. [Fig. 54C] FIG. 51C is a side perspective view of the septum and stent of the aortic repair device of FIGS. 51A-51C in accordance with an embodiment of the present technology. [Figure 55A] 51A-51C in accordance with an additional embodiment of the present technology. FIG. [Figure 55B] FIG. 51C is a perspective end view of a base member of the aortic repair device of FIGS. 51A-51C in accordance with an additional embodiment of the present technology. [Figure 55C] 55A and 55B including a first spanning member, a second spanning member, and a third spanning member coupled to the base member in accordance with an embodiment of the present technology. [Fig. 55D] 55A and 55B including a first spanning member, a second spanning member, and a third spanning member coupled to the base member in accordance with an embodiment of the present technology. [Figure 56A] FIG. 13 is an enlarged isometric end view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 56B] 56B is a side view of the aortic repair device of FIG. 56A during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 56C] 56B is a side view of the aortic repair device of FIG. 56A during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 57] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 58A] 1 is a side view of an aortic repair device implanted in an aorta in accordance with an additional embodiment of the present technology; [Figure 58B] 58B are side views of the aortic repair device of FIG. 58A implanted in the aorta in different configurations in accordance with embodiments of the present technology. [Figure 58C] FIG. 58C is a side view of the aortic repair device of FIG. 58B implanted in the aorta and including an additional extension member in accordance with an embodiment of the present technology. [Figure 59] FIG. 1 is a side view of an aortic repair device configured in accordance with an embodiment of the present technology. [Figure 60A] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 60B] FIG. 60B is a cross-sectional view of the aortic repair device of FIG. 60A taken along line 60B-60B in accordance with an embodiment of the present technology. [Figure 60C] FIG. 60B is a cross-sectional view of the aortic repair device of FIG. 60A taken along line 60B-60B in accordance with an embodiment of the present technology. [Figure 61A] 1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Figure 61B] 1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Figure 61C]1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Figure 61D] 1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Figure 61E] 1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Fig.61F] 1A-1C are side views of various stages of a procedure for implanting an aortic repair device in an aorta in accordance with an embodiment of the present technology. [Figure 62A] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an embodiment of the present technology. [Figure 62B] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an embodiment of the present technology. [Figure 63A] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 63B] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an additional embodiment of the present technology. [Fig. 64A] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 64B] FIG. 61C is a schematic illustration of the aortic repair device of FIGS. 61A-61F implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 65A] FIG. 1 is a side view of an aortic repair device implanted in the ascending aorta in accordance with an embodiment of the present technology. [Figure 65B] FIG. 65B is a side view of the aortic repair device of FIG. 65A implanted in the descending aorta in accordance with an embodiment of the present technology. [Figure 66A] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 66B] FIG. 66B is a cross-sectional view of the aortic repair device of FIG. 66A taken along line 66B-66B of FIG. 66A in accordance with an additional embodiment of the present technology. [Figure 67A] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 67B] FIG. 67B is a cross-sectional view of the aortic repair device of FIG. 67A taken along line 67B-67B of FIG. 67A in accordance with an additional embodiment of the present technology. [Figure 68A] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 68B] FIG. 68B is a cross-sectional view of the aortic repair device of FIG. 68A taken along line 68B-68B of FIG. 68A in accordance with an additional embodiment of the present technology. [Figure 69A] FIG. 13 is a side view of an aortic repair device implanted in the aorta in accordance with an additional embodiment of the present technology. [Figure 69B] FIG. 69B is a cross-sectional view of the aortic repair device of FIG. 69A taken along line 69B-69B of FIG. 69A in accordance with an additional embodiment of the present technology. [Figure 70] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 71] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 72A] FIG. 13 is an enlarged isometric side view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 72B] FIG. 13 is an enlarged isometric side view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Figure 73A] 72C are end views illustrating sequential folding of the anchors of the base member of FIGS. 72A and 72B for loading into a delivery catheter system in accordance with an embodiment of the present technology. [Figure 73B]72C are end views illustrating sequential folding of the anchors of the base member of FIGS. 72A and 72B for loading into a delivery catheter system in accordance with an embodiment of the present technology. [Fig. 74A] FIG. 72C is an enlarged isometric side view of a base member of the aortic repair device of FIG. 72B in accordance with an embodiment of the present technology. [Fig. 74B] FIG. 72C is an enlarged isometric side view of a base member of the aortic repair device of FIG. 72B in accordance with an embodiment of the present technology. [Fig. 75A] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 75B] FIG. 13 is an enlarged isometric side view of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 75C] FIG. 75C is an isometric side view of a stent from the aortic repair device of FIGS. 75A and 75B in accordance with an embodiment of the present technology. [Fig. 75D] FIG. 75A-75C are side views of the aortic repair device implanted in the aorta in accordance with an embodiment of the present technology. [Figure 76A] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 76B] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 76C] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 77A] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Fig. 77B] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Fig. 78A] 1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Fig. 78B]1A-1D are side views of an arterial repair device during different stages of implantation within the aorta in accordance with an embodiment of the present technology. [Figure 79A] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 79B] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 80] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Figure 81A] FIG. 1 is a side view of an aortic repair device implanted in an aorta in accordance with an embodiment of the present technology. [Fig. 81B] FIG. 81B is an enlarged isometric side view of a portion of the aortic repair device of FIG. 81A in accordance with an embodiment of the present technology. [Fig. 82A] FIG. 13 is a side view of a bifurcation perfusion member in accordance with an embodiment of the present technology. [Fig. 82B] FIG. 13 is a side view of a spanning member in accordance with an embodiment of the present technology; [Fig. 82C] FIG. 82C is a side view of a portion of a modularly assembled aortic repair device including the bifurcation perfusion member and spanning member of FIGS. 82A and 82B in accordance with an embodiment of the present technology. [Figure 83A] FIG. 13 is a side perspective view of a spanning member of an aortic repair device in accordance with an embodiment of the present technology. [Figure 83B] FIG. 13 is a distal-facing perspective end view of a spanning member of an aortic repair device in accordance with an embodiment of the present technology. [Figure 84] FIG. 13 is a side perspective view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 85A] FIG. 13 is a side perspective view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Fig. 85B] FIG. 13 is a distal-facing perspective end view of a base member of an aortic repair device in accordance with an embodiment of the present technology. [Figure 86] FIG. 13 is a side view of an aortic repair device in accordance with an embodiment of the present technology. [Figure 87A] FIG. 13 is a side view of a spanning member in a first position in accordance with an embodiment of the present technology. [Fig. 87B] FIG. 13 is a side view of a spanning member in a second position in accordance with an embodiment of the present technology. [Fig. 87C] FIG. 87C is an enlarged side view of a portion of the spanning member of FIGS. 87A and 87B in accordance with an additional embodiment of the present technology. [Fig. 88A] FIG. 13 is a side perspective view of a spanning member of an aortic repair device in a first position in accordance with an embodiment of the present technology. [Fig. 88B] FIG. 13 is a side perspective view of a spanning member of an aortic repair device in a second position in accordance with an embodiment of the present technology. [Fig. 88C] 88C is an enlarged side view of a portion of the spanning member of FIGS. 88A and 88B illustrating two different potential attachments of the elastic fibers of the tension member in accordance with an embodiment of the present technology. [Figure 89A] FIG. 13 is a side perspective view of a base member of an aortic repair device in a first position in accordance with an embodiment of the present technology. [Figure 89B] FIG. 13 is a side perspective view of a base member of an aortic repair device in a second position in accordance with an embodiment of the present technology. [Figure 90A] 1 is a close-up view of a pair of stents, components of an aortic repair device, in a free state, in accordance with an embodiment of the present technology. [Figure 90B] 1 is a close-up view of a pair of stents, components of an aortic repair device, in a compacted state in accordance with an embodiment of the present technology. [Figure 90C] 90A and 90B in a free state, following attachment of one or more tensioning sutures to the stent, in accordance with an embodiment of the present technology. [Figure 90D] 90A and 90B in a compacted state, following attachment of one or more tensioning sutures to the stent in accordance with an embodiment of the present technology. [Figure 90E]90C and 90D in a free state in accordance with an embodiment of the present technology. FIG. [Fig. 90F] 90C and 90D in a compacted state in accordance with an embodiment of the present technology. FIG. [Figure 91A] 90A-90D in a magnified view of the stent in a free state in accordance with an additional embodiment of the present technology. [Figure 91B] FIG. 90C is a close-up view of the stent of FIGS. 90A-90D in a compacted state in accordance with an additional embodiment of the present technology. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] The present technology relates to devices and associated systems and methods for treating a diseased aorta in a patient (e.g., a human patient, etc.). In some embodiments, for example, an aortic repair device includes a base member configured to be implanted at least partially in a proximal region of the aorta proximate a diseased portion of the aorta (e.g., an aneurysm or dissection, etc.). The base member can provide a conduit for directing blood flow through the diseased portion of the aorta and perfuse a portion of the aorta distal to the diseased portion and / or various branch vessels. In some embodiments, one or more spanning members or other implants can be coupled (e.g., docked) to the base member during the same or a separate endovascular procedure to provide additional flow conduits through the diseased portion.

[0008] Specific details of some embodiments of the present technology are described herein with reference to Figures 1-91B. However, the present technology can be practiced without some of these specific details. In some cases, well-known structures and techniques often associated with catheter-based delivery systems and implantable repair devices, etc., are not shown in detail so as not to obscure the present technology. The terminology used in the description presented below is intended to be interpreted in its broadest reasonable manner, even if it is used in connection with the detailed description of certain specific embodiments of the present disclosure. Certain terms may be highlighted below, but any terminology intended to be interpreted in any limited manner will be so expressly and specifically defined in this detailed description section.

[0009] The accompanying figures depict embodiments of the present technology and are not intended to limit its scope. The sizes of the various depicted elements are not necessarily drawn to scale, and these various elements may be arbitrarily enlarged to improve legibility. Details of components may be abstracted in the figures to exclude details such as the location of components and specific precise connections between such components when such details are not necessary for a complete understanding of how to make and use the technology. Many of the details, dimensions, angles, and other features shown in the figures are merely illustrative of certain embodiments of the present disclosure. Thus, other embodiments may have other details, dimensions, angles, and features without departing from the spirit or scope of the present technology.

[0010] When used in reference to an aortic repair device, the term "distal" can refer to a portion of the aortic repair device that is positioned and / or configured to be positioned further from the heart and downstream in the blood flow path, while the term "proximal" can refer to a portion of the aortic repair device that is positioned and / or configured to be positioned closer to the heart and upstream in the blood flow path. In contrast, when used in reference to a catheter subsystem or delivery procedure, the term "distal" can refer to a portion of the catheter system that is further from the operator and / or handle, while the term "proximal" can refer to a portion of the catheter system that is closer to the operator and / or handle. Thus, as described below, in many cases, the proximal portion of the aortic repair device is farther from the operator and / or handle of the catheter system used to deliver the aortic repair device than the distal portion of the aortic repair device. Similarly, in many cases, the distal portion of the aortic repair device is closer to the operator and / or handle of the catheter system than the proximal portion.

[0011] Additionally, as used herein, designations such as "rear-facing," "forward-facing," "upward-facing," "downward-facing," etc. are not meant to limit the referenced components to use in a particular orientation. Such designations refer to the orientation of the referenced components as illustrated in the figures, with it being recognized that the systems of the present technology may be used in any orientation suitable to a user.

[0012] The headings provided herein are for convenience only and should not be construed as limiting the subject matter disclosed.

[0013] I. Overview 1A and 1B are side views of a diseased aorta and surrounding anatomical structures into which an aortic repair device may be implanted according to an embodiment of the present technology. Referring together to FIGS. 1A and 1B, the aorta is the largest blood vessel in the human body, carrying oxygen-rich blood away from the left ventricle and aortic valve of the heart for circulation to all parts of the body. The aorta is divided into different segments, including the ascending aorta (which extends from the left ventricle), the aortic arch, and the descending thoracic aorta. The ascending aorta and the aortic arch together can be referred to as the "proximal aorta." The aorta includes branches into several supra-aortic arteries, including the brachiocephalic artery, the left common carotid artery, and the left subclavian artery, each of which extends from the aortic arch. The brachiocephalic artery is the first branch of the aortic arch and sends blood flow to the right common carotid artery and the right subclavian artery for supplying the right arm, head, and neck. It is also known as the innominate artery or brachiocephalic trunk. The left common carotid artery is the second branch of the aortic arch and sends blood flow to the left head and neck. The left subclavian artery is the third branch of the aortic arch and sends blood flow to the left arm.

[0014] Affected aortas include aneurysms in the ascending aorta in FIG. 1A and aneurysms in the aortic arch in FIG. 1B. An aortic aneurysm is a thickening (e.g., dilation) of the aorta that weakens the aorta and increases the likelihood of rupture. Most people with aortic aneurysms have no symptoms until the aorta ruptures, and the mortality rate following an aortic aneurysm rupture can be greater than 90%. In many cases, aortic aneurysms are detected during routine medical tests, such as chest x-rays, computed tomography (CT) imaging, cardiac ultrasound imaging, and magnetic resonance imaging (MRI).

[0015] 2A-2D are cross-sectional side views of diseased aortas into which an aortic repair device may be implanted according to an embodiment of the present technology. Diseased aortas include a smaller type A aortic dissection in FIG. 2A and a larger type A aortic dissection in FIG. 2B. Diseased aortas include a smaller type B aortic dissection in FIG. 2C and a larger type B aortic dissection in FIG. 2D. An aortic dissection is a tear in the intimal layer of the aorta, which causes blood to dissect the intimal layer and block flow. A type A aortic dissection may occur in the proximal aorta (e.g., the ascending aorta) and extend progressively from the ascending aorta, along the aortic arch and / or down the descending aorta, as shown in FIG. 2B. A type B aortic dissection may occur in the descending aorta and extend progressively down the descending aorta, as shown in FIG. 2D. Aortic dissections can be acute or chronic, with acute aortic dissections often causing the sudden onset of severe pain in the chest, back, and / or abdomen. Most acute aortic dissections require emergency surgery and pose approximately a 1% risk of death every hour for the first two days after dissection, meaning that urgent diagnosis and surgery are critical to the patient's treatment.

[0016] 1A-2D together, aspects of the present technology relate to an aortic repair device that may be implanted in the aorta to treat aortic aneurysm, type A aortic dissection, type B aortic dissection, and / or other types of disease conditions. In some embodiments, the aortic repair device can span across the origin of the aneurysm or dissection and provide one or more flow conduits for diverting blood flow away from and / or through the diseased portion. In some embodiments, the aortic repair device can span between the aorta and one or more branch arteries and provide one or more flow conduits for directing blood flow between the aorta and one or more branch arteries.

[0017] II. SELECTED EMBODIMENTS OF AORTIC REPAIR DEVICES INCLUDE INTERNAL SEPTUM AND / OR INTERNAL ATTACHMENT MECHANISM 3A and 3B are side and side perspective views, respectively, of an aortic repair device 300 (which may also be referred to as an aortic prosthesis, an aortic treatment device, and / or an aortic implant, etc.) in accordance with an embodiment of the present technology. Referring together to FIGS. 3A and 3B, in the illustrated embodiment, aortic repair device 300 includes a base member 310 configured to be implanted within a diseased aorta. Base member 310 includes a tubular body portion 312 (e.g., main body portion) and a tubular leg portion 314 extending distally from body portion 312. More specifically, body portion 312 includes a proximal (e.g., first, leading) end portion 311 that defines a proximal (e.g., first, leading) end of base member 310, and a distal (e.g., second, trailing) end portion 313. The legs 314 include a proximal (e.g., first, leading) end portion 315 that is coupled to and / or extends integrally from the distal end portion 313 of the body portion 312 and a distal (e.g., second, trailing) end portion 317 that defines a distal (e.g., second, trailing) end of the base member 310. In the illustrated embodiment, the body portion 312 has a first length L1 (FIG. 3A) and the legs 314 have a second length L2 (FIG. 3A) that is less than the first length L1. In some embodiments, the second length L2 is the same as or greater than the first length L1. In some embodiments, the first length L1 can be between about 20 and 120 millimeters, and the second length L2 can be between about 20 and 120 millimeters.

[0018] Figure 3C is a cross-sectional view of aortic repair device 300 of Figures 3A and 3B taken along line 3C-3C of Figure 3A in accordance with an embodiment of the present technology. Referring together to Figures 3A-3C, base member 310 can be generally hollow and can define one or more lumens (e.g., flow conduits) therethrough. Thus, in the illustrated embodiment, the base member 310 includes (i) a proximal opening 320 (e.g., a fluid opening, a first opening, a first body fluid opening, and / or an inlet, etc.) at the proximal end portion 311 of the body portion 312 and having a first diameter D1 (FIG. 3A), (ii) a distal body opening 321 (e.g., a fluid opening, a second opening, a second body fluid opening, and / or a distal body outlet, etc.) at the distal end portion 313 of the body portion 312 and having a second diameter D2 (FIG. 3A), and (iii) a distal leg opening 322 (e.g., a fluid opening, a third opening, a leg fluid opening, and / or a distal leg outlet, etc.) at the distal end portion 317 of the leg portion 314 and having a third diameter D3 (FIG. 3A). The first diameter D1 is larger than the second and third diameters D2, D3 and can be sized to generally match or be larger than (e.g., oversized relative to) the diameter of the patient's aorta (e.g., between about 20-60 mm, between about 26-54 mm, about 40 mm). The third diameter D3 can be sized to generally match or be larger than (e.g., between about 10-22 mm, about 16 mm) a bifurcation vessel of the patient's aorta, such as the brachiocephalic trunk. In some embodiments, the second diameter D2 can be larger than the third diameter D3.

[0019] In some embodiments, base member 310 further includes a septum 318 (e.g., a flow divider) positioned within body portion 312 and dividing body portion 312 into a primary lumen 323 (FIG. 3C; e.g., a first lumen) and a branch or secondary lumen 325 (FIG. 3C; e.g., a second lumen). Body portion 312 is shown as partially transparent in FIG. 3A to allow the septum 318 to be visible, and the septum is partially obscured in FIG. 3B. In the illustrated embodiment, the septum 318 (i) extends entirely through the body portion 312 between the proximal end portion 311 and the distal end portion 313, and (ii) is centrally located within the body portion 312 such that the septum 318 extends along a first diameter D1 and the primary and secondary lumens 323, 325 have the same size (e.g., cross-sectional area, volume) within the body portion 312. As described in more detail below, in other embodiments, the septum 318 can (i) extend only partially through the body portion 312 and / or (ii) be offset within the body portion 312 such that the primary and secondary lumens 323, 325 have different sizes. In yet other embodiments described below, the body portion 312 can include multiple septa dividing the body portion into three or more lumens.

[0020] The primary lumen 323 can extend from the proximal opening 320 and the body opening 321 and define a flow path (e.g., a conduit) between the proximal opening 320 and the body opening 321. Similarly, the secondary lumen 325 can extend from the proximal opening 320 and the leg opening 322 and define a flow path between the proximal opening 320 and the leg opening 322. As shown in FIG. 3C, the primary lumen 323 and the secondary lumen 325 can each have a D-shaped cross-sectional shape in the body portion 312 because the septum 318 divides the lumen defined by the body portion 312 in two. The secondary lumen 325 can have a circular cross-sectional shape in the leg portion 314.

[0021] In some embodiments, the base member 310 is an expandable stent graft including one or more stents 326 and graft material 328. The stent 326 can include one or more interconnected struts and can also be referred to as a stent structure. The body 312 and legs 314 can be integrally formed as part of the same stent graft or can be separate components that are releasably or permanently connected together. The graft material 328 can comprise fabric, woven polyester, polytetrafluoroethylene, polyurethane, silicone, and / or other suitable materials known in the stent graft art and is configured to inhibit or even prevent blood flow therethrough. In some embodiments, the septum 318 includes the same material as the graft material 328 or includes another type of graft material. Thus, the graft material 328 and the septum 318 can define and surround the primary lumen 323 and the secondary lumen 325 and are configured to maintain blood flow along the flow path defined thereby. As described in more detail below, in some embodiments, septum 318 can include a non-graft material, such as a metal mesh that is permeable to blood. In some such embodiments, aortic repair device 300 can include one or more sealing features positioned proximate distal end portion 313 of body portion 312.

[0022] The stents 326 may extend circumferentially to define the tubular shape of the body 312 and legs 314 and may be interconnected or separate. In some embodiments, the stents 326 have the illustrated V-pattern shape (e.g., including alternating proximal and distal apices). The stents 326 may be coupled to the outer surface of the graft material 328 as shown in FIGS. 3A-3C via sewing and / or suitable techniques, and / or may be coupled to the inner surface of the graft material 328. The stents 326 may be configured to self-expand and thus may be formed from a shape memory material (e.g., nickel-titanium alloy (nitinol) or the like). In other embodiments, the shape of the stents 326, the number of stents 326, and / or the arrangement of the stents 326 may be varied.

[0023] FIG. 3D is a side view of an aortic repair device 300 implanted in the aorta, according to an embodiment of the present technology. In some embodiments, the aorta may include an aneurysm, dissection, and / or other diseased portion, as described in detail above with reference to FIGS. 1A-2B. In the illustrated embodiment, the body portion 312 is implanted in the proximal aorta (e.g., the ascending aorta and / or aortic arch) with the proximal end portion 311 positioned adjacent to the aortic valve, the leg portion 314 extends from the body portion 312 to the brachiocephalic artery, and the distal end portion 317 is positioned in the brachiocephalic artery. Referring together to FIGS. 3A-3D, the stent 326 can expand the graft material 328 into contact with the inner wall of the aorta and / or brachiocephalic artery to provide a seal between the blood vessel and the base member 310. More specifically, body portion 312 can sealingly contact the inner wall of the proximal aorta such that all or substantially all blood flow through the aorta enters proximal opening 320 and flows through either primary lumen 323 or secondary lumen 325. As shown in FIGURE 3D, base member 310 can direct blood flow (i) from body portion opening 321 through primary lumen 323 into the aorta to perfuse the aorta, and can also direct blood flow (ii) from leg opening 322 through secondary lumen 325 into the brachiocephalic artery to perfuse the brachiocephalic artery.

[0024] In some aspects of the present technology, the base member 310 can be positioned against / adjacent to a diseased portion of the aorta (e.g., origin of a dissection and / or aneurysm, etc.) and block blood flow into the diseased portion by diverting blood flow through the base member 310. In additional aspects of the present technology, the entire outer surface of the body portion 312 has a tubular shape configured to engage and seal with the inner wall of the aorta. That is, the body portion 312 can provide a relatively long sealing area along all or substantially all of the first length L1.

[0025] The base member 310 can be delivered to the aorta in a collapsed configuration within a catheter system (not shown) that can access the aorta via any suitable intravascular route, such as an aortic approach, a transfemoral approach, a transcarotid approach, and a transsubclavian approach.

[0026] In some embodiments, other implantable devices can be modularly coupled to the base member 310 during the same or different surgical / interventional procedures, as described in detail below. For example, the length L2 of the leg 314 can be relatively short such that a distal end portion 317 of the leg 314 is positioned in the aorta, and a separate tubular stent graft or other implant can be coupled to the leg 314 and extend into the brachiocephalic artery or another bifurcation vessel. Similarly, a separate tubular stent graft or other implant can be coupled to the body portion 312 and extend further through the aorta and / or to a bifurcation vessel.

[0027] As described in detail below, in some embodiments, the base member 310 can be implanted in the descending aorta in a reversed or inverted orientation. Thus, in an inverted orientation, the "distal" portion of the base member 310 is instead the "proximal" portion of the base member 310, and vice versa. Thus, one skilled in the art will understand that the use of the terms "proximal" and "distal" can be based on the orientation of the base member 310 or can refer to corresponding structures of the base member 310 (i.e., the "distal" and "proximal" portions can refer to corresponding structures of the base member 310 as described in detail herein, regardless of the actual orientation of the base member 310 within the aorta). Similarly, the terms "distal" and "proximal" can be substituted with terms such as "first" and "second" and / or "leading" and "trailing".

[0028] 4A is a side view of an aortic repair device 400a implanted in the aorta in accordance with an embodiment of the present technology. In the illustrated embodiment, aortic repair device 400a includes a base member 310, described in detail above with reference to FIGS. 3A-3D , and a separate spanning member 450 coupled to (e.g., attached to, docked to) base member 310. Spanning member 450 can have a tubular shape defining a lumen and can include generally similar features to those of base member 310. For example, in some embodiments, spanning member 450 is an expandable stent graft including one or more struts or stents 456 and a graft material 458 coupled to stent 456.

[0029] In the illustrated embodiment, the spanning member 450 includes a proximal end portion 451 (e.g., a first end portion and / or a leading end portion, etc.; partially obscured by the base member 310) that defines a proximal end of the spanning member 450, and a distal end portion 453 (e.g., a second end portion and / or a trailing end portion, etc.) that defines a distal end of the spanning member 450. The spanning member 450 can be generally hollow and can define one or more lumens (e.g., flow conduits) therethrough. Thus, in the illustrated embodiment, the spanning member 450 includes a proximal opening (e.g., a fluid opening, a first spanning fluid opening, and / or a leading spanning fluid opening, etc.; obscured by the base member 310) and a distal opening 455 (e.g., a fluid opening, a second spanning fluid opening, and / or a trailing spanning fluid opening, etc.).

[0030] 3A-4A together, proximal end portion 451 of spanning member 450 is at least partially positioned within body portion 312 within primary lumen 323 and is sealingly engaged to body portion 312 within primary lumen 323 to define a continuous blood flow path from proximal opening 320 of base member 310, through primary lumen 323, through the lumen of spanning member 450 to distal opening 455. That is, graft material 458 of spanning member 450 is sealingly engaged to septum 318 and graft material 328 of base member 310 within primary lumen 323 such that blood flow is routed through primary lumen 323 to the lumen of spanning member 450. In some aspects of the present technology, septum 318 extends the entire length of body portion 312 such that septum 318 provides a docking or sealing region for engaging spanning member 450 along the entire length of primary lumen 323. In some embodiments, at least a portion of spanning member 450 (e.g., distal end portion 453) sealingly engages the aorta in the aortic arch and / or descending thoracic aorta. Thus, aortic repair device 400 is capable of directing blood flow through secondary lumen 325 to the brachiocephalic trunk and through primary lumen 323 and spanning member 450 to the descending thoracic aorta.

[0031] Thus, in some aspects of the present technology, aortic repair device 400 can divert blood flow past a diseased portion of the aorta (such as, for example, an aneurysm in the aortic arch shown in FIG. 4). In some embodiments, spanning member 450 can be delivered to the aorta in a collapsed configuration in a catheter system (not shown) in the same or separate procedure as base member 310. For example, often a patient may initially require treatment only in the ascending aorta and / or aortic arch to treat an initial dissection or aneurysm, but at a later point in time (e.g., months or years later) may require additional treatment of the aortic arch and / or descending thoracic aorta as the diseased condition progresses. Thus, base member 310 can be implanted during an initial procedure, and spanning member 450 can be implanted during a later procedure and modularly coupled to base member 310 to provide additional treatment of the aortic arch and / or descending thoracic aorta (e.g., by bypassing blood flow past the aneurysm shown in FIG. 4).

[0032] 4A, spanning member 450 can bypass the left common carotid artery and the left subclavian artery, thus partially or completely occluding those vessels. In some embodiments, a bypass 402 between the perfused brachiocephalic arteries and / or a bypass 404 between the left common carotid artery and the left subclavian artery (and / or between the brachiocephalic artery and the left subclavian artery) can be surgically created to perfuse those vessels. In other embodiments, described in detail below, aortic repair device 400 can include additional implantable devices (e.g., stent grafts) coupled to spanning member 450 and / or base member 310 that are configured (e.g., sized, shaped, positioned) to perfuse different branch vessels. Similarly, in some embodiments, spanning member 450 does not sealingly engage the aorta, allowing blood to flow retrogradely into the left subclavian artery and the left common carotid artery to perfuse those vessels.

[0033] 4B is a side view of an aortic repair device 400b implanted in the aorta, according to an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 400a includes a base member 310 (identified as first base member 310a), described in detail above with reference to FIGS. 3A-3D, and a spanning member 450 coupled to (e.g., attached to, docked to) the first base member 310a. In the illustrated embodiment, the aortic repair device 400b further includes a second base member 310b (which can be identical or substantially identical to the first base member 310a) that is implanted at least partially in the descending thoracic aorta. The spanning member 450 spans from and is coupled to the second base member 310b. Specifically, referring together to Figures 3A-4B, the distal end portion 453 of the spanning member 450 can be positioned within the primary lumen 323 of the second base member 310b and can be sealingly engaged therewith to define a continuous blood flow path from the spanning member 450, through the primary lumen 323, and out the proximal opening 320 of the second base member 310b. The leg 314b of the second base member 310b can extend into the second branch artery (e.g., the left subclavian artery) to perfuse the second branch artery. For example, the second base member 310b can receive retrograde blood flow through the trailing opening 320 to perfuse the second branch artery. Alternatively or additionally, the secondary lumen 325 of the second base member 310b can be perfused through a primary lumen 323 in which a septum 318 extends only partially from the leading end portion 313 to the trailing end portion 311. That is, blood flow from the spanning member 450 can flow into the primary lumen 323 in the body portion 312, around the septum 318, and into the secondary lumen 325 (where the septum 318 terminates in the body portion 312).In some aspects of the present technology, the aortic repair device 400b is capable of providing a full-arch treatment, in which (i) the leg 314a of the first base member 310a directs blood flow to a first branch artery (e.g., the brachiocephalic artery), (ii) the leg 314b of the second base member 310b directs blood flow to a second branch artery (e.g., the left subclavian artery), (iii) a third branch artery (e.g., the left common carotid artery) is perfused via bypasses 402 and / or 404, and (iv) the primary lumens and spanning member 450 of the first and second base members 310a-b collectively direct blood flow to the descending thoracic aorta.

[0034] 5A-8H illustrate additional embodiments of aortic repair devices including base members and / or spanning members in accordance with embodiments of the present technology. The various aortic repair devices can include some features that are at least generally similar in structure and function to (or identical in structure and function to) each other and / or to corresponding features of aortic repair devices 300 and 400 described in detail above with reference to FIGS. 3A-4, and can operate in a generally similar or identical manner to each other and / or to aortic repair devices 300 and 400. Moreover, one or more of the different features of the aortic repair devices of the present technology can be combined and / or omitted.

[0035] 5A is a side view of an aortic repair device 500 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 500 includes a base member 510 having a body portion 512 and legs 514. The body portion 512 includes a proximal end portion 511, a distal end portion 513, and a septum 518 that extends only partially from the distal end portion 513 toward the proximal end portion 511. That is, the septum 518 extends only partially through the body portion 512 and has a second length L2 that is less than the first length L1 of the body portion 512. In some aspects of the present technology, the septum 518 reduces the volume of the base member 510 (e.g., the total volume anywhere along the length of the aortic repair device 500 and / or the maximum volume per unit length) compared to a septum that extends completely through the body portion 512 (e.g., has a second length L2 equal to the first length L1). In some aspects of the present technology, reducing the volume of base member 510 can reduce the delivery profile of aortic repair device 500, potentially allowing aortic repair device 500 to be loaded into and delivered through a relatively smaller catheter and / or delivered along a narrower intravascular delivery path. However, a shorter septum 518 can reduce the available area for sealingly engaging (e.g., docking) with a spanning member (such as spanning member 550 shown in FIG. 5C ). In the illustrated embodiment, legs 514 further include angled portions 519 extending from body portion 512, which reduce the diameter of the secondary lumen defined by legs 514. Additionally, because septum 518 extends only partially through body portion 512, body portion 512 can define a sealing region near a proximal end portion 511 of body portion 512, which can receive an extension member, as described in more detail below with reference to FIG. 36C . Such an extension member can be coupled to the proximal end portion 511 of the body portion 512 to provide additional sealing and / or anchoring within the aorta.

[0036] 5B and 5C are cross-sectional views of aortic repair device 500 of FIG. 5A taken along line 5B-5B of FIG. 5A in accordance with an embodiment of the present technology. With reference to FIG. 5B, body portion 512 has a generally circular cross-sectional shape and septum 518 is generally centrally disposed within body portion 512 such that septum 518 divides (e.g., splits) body portion 512 into primary lumen 523 and secondary lumen 525 having the same size. FIG. 5C illustrates aortic repair device 500 with spanning member 550 coupled to base member 510 within primary lumen 523 and defining spanning lumen 557. In the illustrated embodiment, an outer surface of spanning member 550 is at least partially sealingly engaged with septum 518 and an inner surface of body portion 512 such that blood flow is substantially routed through spanning lumen 557.

[0037] In some embodiments, the spanning member 550, when expanded within the body portion 512 as shown in FIG. 5C, deflects the septum 518 away from the center of the body portion 512. This deflection can increase the cross-sectional size of the primary lumen 523 and the volumetric flow rate provided by the primary lumen 523 while decreasing the cross-sectional size of the secondary lumen 525 and the corresponding volumetric flow rate provided by the secondary lumen 525. In some aspects of the present technology, this change in size of the primary and secondary lumens 523, 525 is advantageous because the primary lumen 523 is positioned to perfuse the aorta and all its branch vessels, while the secondary lumen 525 is positioned to perfuse the branch vessels that require less blood flow than the aorta. However, in some embodiments, the shape of the secondary lumen 525 when the spanning member 550 is deployed (e.g., a thin crescent shape) can restrict blood flow through the secondary lumen 525. Thus, as described in more detail below, in some embodiments, the body portion 512 can be shaped differently and / or the septum 518 can be positioned differently to promote more uniform blood flow through the primary and secondary lumens 523, 525 and / or blood flow through the primary and secondary lumens 523, 525 that is proportional to the physiological needs of the patient (e.g., a situation in which the aorta receives more blood flow than the bifurcation vessels).

[0038] FIG 6A is a side view of an aortic repair device 600 in accordance with an embodiment of the present technology. FIG 6B is a cross-sectional view of the aortic repair device 600 in FIG 6A taken along line 6B-6B in FIG 6A in accordance with an embodiment of the present technology. With reference to FIG 6A, aortic repair device 600 includes a base member 610 having a body portion 612 and legs 614. Body portion 612 includes a proximal end portion 611, a distal end portion 613, and a septum 618 that extends only partially from distal end portion 613 toward proximal end portion 611. That is, septum 618 can terminate at a predetermined distance from proximal end portion 611. 6B, body portion 612 has a generally circular cross-sectional shape and septum 618 is offset within body portion 612 such that septum 618 divides body portion 612 into primary lumen 623 and secondary lumen 625, the secondary lumen 625 having a smaller size and corresponding volumetric flow rate than primary lumen 623. In some embodiments, septum 618 is configured to not deflect, or to deflect only slightly, when the spanning member is disposed within primary lumen 623.

[0039] 7A and 7B are, respectively, a distal-facing perspective end view and a distal-facing end view of an aortic repair device 700 in accordance with an embodiment of the present technology. Referring together to FIGS. 7A and 7B, aortic repair device 700 includes a base member 710 having a body portion 712 with a septum 718 extending completely or partially therethrough and defining a primary lumen 723 and a secondary lumen 725. In the illustrated embodiment, when aortic repair device 700 is expanded without radial constraint (e.g., outside the aorta), body portion 712 has a minor diameter D Minor (Figure 7A) and major diameter D Major (FIG. 7A). The septum 718 has an oval cross-sectional shape with a minor diameter D Minor It is possible to extend along the minor diameter D Minor, such that the septum 718 is loose or floppy (e.g., not fully tensioned) when the base member 710 is expanded outside the aorta. In some embodiments, the septum 718 has a minor diameter D Minor 7, so that the septum 718 is taut (eg, minimally floppy).

[0040] 7A-7C are a distal end view of an aortic repair device 700 expanded within an aorta, in accordance with an embodiment of the present technology. Major 7. The aorta may be oversized along a major diameter D when the base member 710 is expanded within the aorta. Major In some embodiments, the minor diameter D Minor can be selected to match the size of the aorta or be oversized relative to the aorta, and when implanted in the aorta, has a minor diameter D Minor Generally, the minor diameter D Minor The major diameter D can be chosen to be smaller than the size of the aorta. Major 4. Compression of the body portion 712 along the minor diameter D Minor 7, thereby increasing tension in the septum 718. That is, in such an embodiment, the body portion 712 has a major diameter D Major is reduced, the minor diameter D MinorWith increased tension on the septum 718, the septum 718 can assume a generally circular cross-sectional shape in the aorta. In some aspects of the present technology, the increased tension on the septum 718 can inhibit substantial deflection of the septum 718 by the spanning member (not shown) when the spanning member is placed within the primary lumen 723 (e.g., the type of deflection shown in FIG. 5C). This can preserve the size of the flow path through the primary and secondary lumens 723, 725.

[0041] 8A-8E are side, side perspective, proximal facing perspective, proximal facing perspective end, and distal facing perspective end views, respectively, of aortic repair device 800 in accordance with an embodiment of the present technology. Figures 8F and 8G are cross-sectional views of aortic repair device 800 taken along line 8F-8F of Figure 8B in accordance with an embodiment of the present technology. Referring together to Figures 8A-8G, aortic repair device 800 includes a base member 810 having a body portion 812 with a septum 818 extending completely or partially therethrough. Septum 818 is laterally offset within body portion 812 (e.g., as described in detail above with reference to FIGS. 6A and 6B ) such that septum 818 divides body portion 812 into primary lumen 823 and secondary lumen 825, with secondary lumen 825 having a smaller size than primary lumen 823. Septum 818 can be sized (e.g., have a length such that, when base member 810 is expanded, septum 818 has a curved shape and secondary lumen 825 has a corresponding curved cross-sectional shape (e.g., generally circular, generally oval).

[0042] 8D and 8E together, aortic repair device 800 further includes a stent graft or stent 830 positioned at least partially within body portion 812 and in secondary lumen 825. Stent 830 can be delivered and deployed within secondary lumen 825 during the same procedure and / or from the same catheter system used to implant base member 810, and / or can be delivered to secondary lumen 825 in a separate procedure and / or from a different catheter system. In some embodiments, stent 830 is delivered from a separate catheter advanced through a branch lumen (such as the brachiocephalic artery) in which the outlet of leg portion 814 is positioned. Stent 830 can include an expandable mesh of interconnected stents or similar structure and can have a tubular shape with a generally circular cross-sectional shape. When positioned within secondary lumen 825, stent 830 can expand against septum 818 and the inner surface of body portion 812, expanding secondary lumen 825. Thus, when spanning member is disposed within primary lumen 823, stent 830 can help maintain the shape of secondary lumen 825, preserving its cross-sectional area and flow rate.

[0043] For example, Figure 8H is a cross-sectional view of an aortic repair device taken along line 8F-8F of Figure 8B with spanning member 850 deployed in primary lumen 823 in accordance with an embodiment of the present technology. As shown in Figure 8H, spanning member 850 and stent 830 can conform to one another's shapes. More specifically, stent 830 is configured to exert a greater radially outward force than spanning member 850 such that stent 830 inhibits septum 818 from substantially deflecting and narrowing secondary lumen 825, thereby maintaining a good flow path through secondary lumen 825. As shown in Figure 8H, spanning member 850 can slightly compress stent 830 such that stent 830 has a generally oval cross-sectional shape such that spanning member 850 can conform and seal around septum 818 and stent 830.

[0044] 8H , in some embodiments, spanning member 850 may not perfectly fit septum 818 and stent 830 such that one or more gaps 831 exist between spanning member 850 and septum 818 and / or body portion 812. Gaps 831 can exist along areas of septum 818 and body portion 812 that define sharp corners, narrowed areas, and the like. Such gaps 831 can provide leak paths for blood flow through aortic repair device 800.

[0045] 9A-20B illustrate additional embodiments of aortic repair devices that include features for inhibiting (e.g., filling, plugging, preventing) gaps (such as gap 831) in accordance with embodiments of the present technology. The various aortic repair devices can include some features that are at least generally similar in structure and function (or identical in structure and function) to each other and / or to corresponding features of the aortic repair devices described in detail above with reference to FIGS. 3A-8H and can operate in a generally similar or identical manner to each other and / or to the aortic repair devices described above.

[0046] For example, Figures 9A and 9B are cross-sectional views (e.g., end cross-sectional views along a plane perpendicular to the longitudinal axis of primary lumen 823) of aortic repair device 800 of Figure 8H during a first and second delivery stage in accordance with an embodiment of the present technology. With reference to Figure 9A, after implanting aortic repair device 800 in the aorta, balloon catheter assembly 934 can be advanced into spanning member 850. Balloon catheter assembly 934 can include an inflation source 935 and a balloon 936 fluidly coupled to inflation source 935. Inflation source 935 can include one or more inflation lumens configured to route fluid into balloon 936 to inflate / expand balloon 936. Figure 9A shows balloon 936 before inflation, and Figure 9B shows balloon 936 after inflation. 9B, in some embodiments, balloon 936 has a cross-sectional shape that generally matches the profile of primary lumen 823 against which spanning member 950 is to fit and seal. Thus, inflating balloon 936 can help urge spanning member 950 to fit and seal all around primary lumen 823, including into difficult-to-seal gaps 831. After inflating balloon 936 to urge spanning member 950 to fit and seal against body portion 812 within primary lumen 823, balloon 936 can be deflated and balloon catheter assembly 934 can be removed from aortic repair device 800 and the patient.

[0047] In some embodiments, the balloon 936 can have a crescent, D-shaped, semicircular, quarter-circular, or other cross-sectional shape that matches or generally matches the profile (e.g., circumference, perimeter) of the primary lumen 823. In some embodiments, different portions of the balloon 936 can have different flexibility to facilitate a non-circular cross-sectional shape. In some embodiments, the inflation source 935 can inflate the balloon 936 according to a pre-determined sequence, rate, and / or pressure, etc. In some embodiments, one or more additional balloon catheter assemblies can be inserted into the spanning member 850 and / or stent 830. For example, the balloon 936 can be a moderately semi-compliant balloon having a generally circular cross-sectional shape and can be inflated within the spanning member 950 to a point that partially compresses the stent 830 such that the spanning member 850 and balloon 936 reach and fill the gap 831. A non-compliant balloon (not shown) can then be inserted into stent 830 and slowly inflated within stent 830. As the non-compliant balloon inflates to fill secondary lumen 825, it can slowly deflate balloon 936, thereby opening space for expansion but maintaining support in gap 831. In some embodiments, pressure within balloon 936 can be maintained by reducing the inflation pressure of balloon 936 using inflation source 935 as the volume of balloon 936 is compressed and reduced.

[0048] In some embodiments, the balloon 936 can have a generally cylindrical shape and can be inflated to fully compress the stent 830. After fully compressing the stent 830, the balloon 936 can be deflated, allowing the stent 830 to expand against the septum 818 and spanning member 850 to re-create a flow path through the secondary lumen 825. In some aspects of the present technology, fully compressing the stent 830 and septum 818 while positioning the spanning member 850 can promote a better fit between the spanning member 850 and the septum 818, reducing or eliminating the gap 831. In some embodiments, the balloon can be inserted into the stent 830 and expanded within the stent 830 to drive its expansion against the spanning member 850. In other embodiments, the spanning member 850 can be deployed first and the balloon 936 can be expanded before the stent 830 is deployed in the compressed secondary lumen 825 and allowed to expand.

[0049] 10A and 10B are distally facing end and perspective end views, respectively, of an aortic repair device 1000 in accordance with an embodiment of the present technology. Referring together to FIGS. 10A and 10B, in the illustrated embodiment, aortic repair device 1000 includes a base member 1010 having a body portion 1012 with a septum 1018 extending fully or partially therethrough. Septum 1018 is offset laterally within body portion 1012 such that septum 1018 divides body portion 1012 into a primary lumen 1023 and a secondary lumen 1025, the secondary lumen 1025 having a smaller size than the primary lumen 1023. In the illustrated embodiment, the base member 1010 further includes one or more filler sections 1032 (e.g., gussets, caps) coupled to the septum 1018 between the primary lumen 1023 and the secondary lumen 1025. The filler sections 1032 can include fabrics and / or materials that are impermeable to blood flow.

[0050] 10C and 10D are, respectively, a distal-facing end view and a perspective end view of aortic repair device 1000 with spanning member 1050 placed in primary lumen 1023, in accordance with an embodiment of the present technology. FIG. 10C further illustrates optional stent 1030 placed in secondary lumen 1025. Referring together to FIGS. 10C and 10D, in the illustrated embodiment, filler material portion 1032 helps define a relatively uniform oval-like cross-sectional shape of primary lumen 1023. That is, filler material portion 1032 can fill any sharp corners, narrowed regions, etc., where spanning member 1050 may have difficulty conforming (e.g., in the area around gap 831 shown in FIG. 8H). Thus, in some aspects of the present technology, the filler portion 1032 helps improve the fit and sealing of the spanning member 1050 within the body portion 1012, which can reduce or eliminate leakage through the aortic repair device 1000 when the device is placed in the aorta.

[0051] 11A is a cross-sectional view of an aortic repair device 1100 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 1100 includes a base member 1110 having a body portion 1112 with a septum 1118 extending completely or partially therethrough. The septum 1118 is offset laterally within the body portion 1112 such that the septum 1118 divides the body portion 1112 into a primary lumen 1123 and a secondary lumen 1125, the secondary lumen 1125 having a smaller size than the primary lumen 1123. In the illustrated embodiment, a spanning member 1150 is disposed within the primary lumen 1123 and a stent 1130 is disposed within the secondary lumen 1125. As shown, the spanning member 1150 may not completely fit and seal against the circumference of the primary lumen 1123 such that one or more gaps 1131 are present.

[0052] 11B is a cross-sectional side view of a stent 1156 of a spanning member 1150, according to an embodiment of the present technology. The spanning member 1150 can include one or more of the stents 1156 attached to a graft material (not shown; e.g., as described in detail above with reference to FIG. 4). In some embodiments, the stent 1156 has a ring-like shape with a periodic or V-shaped pattern. In the illustrated embodiment, the stent 1156 has a relatively large amplitude and low frequency. In some aspects of the present technology, a relatively large amplitude and low frequency stent 1156 can make the spanning member 1150 relatively easy to manufacture and / or load into a catheter for delivery. However, the spanning member 1150 may not be very conformable as shown in FIG. 11A, causing gaps 1131.

[0053] FIG 12A is a cross-sectional view of an aortic repair device 1200 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 1200 includes a base member 1110 and a stent 1130 as described in detail with reference to FIG 11A, but includes a different spanning member 1250. FIG 12B is a cross-sectional side view of a stent 1256 of the spanning member 1250 in accordance with an embodiment of the present technology. In the illustrated embodiment, the stent 1256 has a relatively small amplitude and a high frequency (e.g., as compared to the stent 1156 described in detail with reference to FIG 11B). In some aspects of the present technology, the relatively small amplitude and high frequency stent 1256 can make the spanning member 1250 relatively more difficult to manufacture (e.g., by requiring additional attachment to the graft material) and / or more difficult to load into a catheter for delivery. However, spanning member 1250 may be more circumferentially compliant, as shown in FIG. 12A, which may eliminate or reduce the presence of gap 1231.

[0054] In general, spanning member stents according to the present technology can be selected to balance radial force (e.g., force apposition) and conformance (e.g., contour conformance) of the spanning member by modifying one or more of the stent amplitude, frequency (e.g., number of apexes), wall thickness, and / or wire diameter / strut geometry and dimensions. For example, the wall thickness of the spanning member can be reduced to improve conformance while reducing radial force. In some embodiments, the manner in which the spanning member lays up on the mating surface can be improved by "scalloping" the unsupported V-spaces at the end portions of the spanning member, resulting in a somewhat sawtooth shape. Additionally, one or both end portions of the spanning member can be flared outwardly for improved apposition. Moreover, the spanning member may include a series of stent rings having different characteristics (e.g., the first stent ring at the end may be softer, with a smaller wire diameter and / or wall thickness and scalloped or flared; the second stent ring may be stiffer, with a larger wire diameter and / or wall thickness, shorter amplitude, etc; the third stent ring may be of a standard / typical design used in conventional stent grafts, etc.).

[0055] 13A-13C, for example, are a side perspective view, a distal facing perspective end view, and another distal facing perspective end view, respectively, of a spanning member 1350 in accordance with an embodiment of the present technology. With reference to FIG. 13A, spanning member 1350 includes a proximal end portion 1351 and a distal end portion 1353, where proximal end portion 1351 is configured to expand within and conform to a base member and distal end portion 1353 is configured to expand within and conform to a blood vessel (e.g., an aorta (e.g., aortic arch, descending thoracic aorta), etc.). Spanning member 1350 includes a plurality of stents 1356 (e.g., including a first stent 1356a and a second stent 1356b, each individually identified) attached to a graft material 1358. In the illustrated embodiment, the first stent 1356a has a larger amplitude and lower frequency than the second stent 1356b. In some embodiments, the first stent 1356a can have a larger wire diameter than the second stent 1356b.

[0056] The second stent 1356b can be positioned at, proximate to, and / or adjacent to the proximal and distal end portions 1351, 1353 to provide increased conformance at the proximal and distal end portions 1351, 1353. FIG. 13C illustrates, for example, a relatively high circumferential conformance of the spanning member 1350 at the proximal end portion 1351 when an outward force, indicated by arrow F, acts on the spanning member 1350 (e.g., as applied by a stent placed in the secondary lumen of the base member). The first stent 1356a can be positioned in a middle region of the spanning member 1350. In some embodiments, the spanning member 1350 includes more of the second stent 1356b near the proximal end portion 1351 such that the proximal end portion 1351 is relatively conformable for docking and sealing with the base member.

[0057] 13A-13C together, in some embodiments, the proximal most one of the second stents 1356b and / or the distal most one of the second stents 1356b have a larger diameter than the others of the stents 1356 such that the spanning member 1350 is flared at one or both of the proximal and distal end portions 1351, 1353. In the illustrated embodiment, the graft material 1358 can be cut to follow the pattern of the proximal most one of the second stents 1356b and / or the distal most one of the second stents 1356b such that the graft material 1358 has a scalloped or V-shaped pattern at one or both of the proximal and distal end portions 1351, 1353. In some aspects of the present technology, such flaring and / or scalloping of the proximal and distal end portions 1351, 1353 can improve the fitting and sealing characteristics of the spanning member 1350.

[0058] 14A and 14B are side perspective views of a spanning member 1450 in accordance with an embodiment of the present technology. Referring together to FIGS. 14A and 14B, spanning member 1450 includes a proximal end portion 1451 configured to expand and conform within a base member and a distal end portion 1453 configured to expand and conform within a blood vessel (e.g., an aorta (e.g., aortic arch, descending thoracic aorta), etc.). Spanning member 1450 includes a plurality of stents 1456 (e.g., including first through eighth stents 1456a-h, each individually identified) attached to a graft material 1458.

[0059] In the illustrated embodiment, the first, second, seventh, and eighth stents 1456a, b, g, h are positioned at the proximal and distal end portions 1451, 1453 and have a smaller amplitude and a larger frequency than the third through sixth stents 1456c-f positioned therebetween. The third through sixth stents 1456c-f can have the same or generally the same frequency, and the third and sixth stents 1456c, f can have a larger amplitude than the fourth and fifth stents 1456d, e positioned therebetween. The first stent 1456a can have a first diameter (e.g., about 44 millimeters). The second through seventh stents 1456b-g can have a second diameter smaller than the first diameter (e.g., about 40 millimeters). The eighth stent 1456h can have a third diameter greater than the second diameter (e.g., about 42 millimeters) and less than the first diameter. Thus, the proximal end portion 1451 can be flared relative to the remainder of the spanning member 1450 to improve fit and sealing to the base member. Similarly, the distal end portion 1453 can be flared relative to the adjacent ones of the stents 1456 (e.g., but flared less than the proximal end portion 1451).

[0060] In some embodiments, the first, second, seventh, and eighth stents 1456a,b,g,h can each have a relatively small first wire diameter (e.g., about 0.14 inches) to provide a high level of radial conformance. The third through sixth stents 1456c-f therebetween can each have a larger second wire diameter to provide a relatively greater radial outward force. For example, in some embodiments, the third through sixth stents 1456c-f can have wire diameters of about 0.025 inches, 0.018 inches, 0.016 inches, and 0.022 inches, respectively. Additionally, in some embodiments, the third through sixth stents 1456c-f can be spaced apart from one another by a distance greater than the distance between the first, second, seventh, and eighth stents 1456a,b,g,h.

[0061] 14C and 14D are perspective distal and enlarged distal end views, respectively, of an aortic repair device 1400 including a spanning member 1450 disposed within a base member 1410 in accordance with an embodiment of the present technology. Referring together to FIGS. 14C and 14D, the base member 1410 includes a body portion 1412 with a septum 1418 extending fully or partially therethrough. The septum 1418 is laterally offset within the body portion 1412 such that the septum 1418 divides the body portion 1412 into a primary lumen 1423 and a secondary lumen 1425, the secondary lumen 1425 having a smaller size than the primary lumen 1423. A stent 1430 is disposed within the secondary lumen 1425. As shown, the relatively conformable proximal portion 1451 of the spanning member 1450 is able to conform and seal around the septum 1418 and stent 1430 without leaving a substantial gap (e.g., a leak path).

[0062] 15A and 15B are side and distal-facing end views, respectively, of a spanning member 1550 in accordance with an embodiment of the present technology. FIG. 15C is a distal-facing end view of an aortic repair device 1500 including the spanning member 1550 of FIG. 15A and 15B in accordance with an embodiment of the present technology. With reference to FIG. 15C, the aortic repair device 1500 can include a base member 1510 having a body portion 1512 with a septum 1518 extending fully or partially therethrough. The septum 1518 is offset laterally within the body portion 1512 such that the septum 1518 divides the body portion 1512 into a primary lumen 1523 and a secondary lumen 1525, the secondary lumen 1525 having a smaller size than the primary lumen 1523. A stent 1530 is disposed within the secondary lumen 1525 .

[0063] 15A-15C together, the spanning member 1550 can include a plurality of stents 1556 attached to a graft material 1558. In the illustrated embodiment, the graft material 1558 includes a filler portion 1559, which can include pockets, loose portions, and / or pouches of the graft material 1558. The filler portion 1559 can extend radially outward from the stent 1556 and can be disposed circumferentially and / or longitudinally around the spanning member 1550. In some embodiments, the filler portion 1559 can protrude outward in response to blood pressure within the vessel, as shown by the arrows in FIG. 15B and FIG. 15C. With reference to FIG. 15C, in some aspects of the present technology, the filler portion 1559 can help the spanning member 1550 to conform and seal around the circumference of the primary lumen 1523 without leaving a substantial gap (e.g., a leak path). In some embodiments, the filler portion 1559 is asymmetrically positioned around the spanning member 1550 (e.g., along only a portion of its circumference) such that the spanning member 1550 can be aligned within the body portion 1512 during a surgical procedure such that the filler portion 1559 engages and surrounds the septum 1518.

[0064] The graft material 1558 can be attached radially outwardly of the stent 1556 or can be attached radially inwardly of the stent 1556 such that the filler portion 1559 extends / extrudes through the stent 1556. Figures 15D and 15E are side views of the spanning member 1550 when undergoing blood flow (e.g., when implanted in a blood vessel (not shown)) and when having graft material 1558 attached to the inside and outside of the stent 1556, respectively, in accordance with an embodiment of the present technology. As shown in Figure 15D, blood flow through / passing the spanning member 1550 can cause the filler portion 1559 to extend radially through the stents 1556 in areas between the stents 1556 when the graft material 1558 is attached to the inside of the stents 1556. As shown in FIG. 15E, blood flow through / through spanning member 1550 can cause filler portion 1559 to bulge outward around the attachment point of graft material 1558 to stent 1556 when graft material 1558 is attached to the outside of stent 1556.

[0065] 16A and 16B are side and end perspective views, respectively, of a spanning member 1650, in accordance with an embodiment of the present technology. Referring together to FIGS. 16A and 16B, the spanning member 1650 includes a graft material 1658 attached to the outside of a number of stents 1656. The graft material 1658 can be oversized relative to the stents 1656 such that the graft material 1658 is loose or pouch-like, thus helping to fill and seal any gaps when the spanning member 1650 is deployed within the base member. For example, the graft material 1658 can have a diameter (e.g., about 50 millimeters) larger than the diameter of the stents 1656 (e.g., about 40 millimeters).

[0066] 17A-17C are side perspective, side cross-sectional, and perspective end views, respectively, of a spanning member 1750, in accordance with an embodiment of the present technology. Referring together to FIGS. 17A-17C, spanning member 1750 includes graft material 1758 attached to a plurality of stents 1756 (including, for example, individually identified proximal-most stent 1756a and distal-most stent 1756b). Graft material 1758 can be oversized relative to stents 1756 such that graft material 1758 is loose or pouch-like, thus helping to fill and seal any gaps when spanning member 1750 is deployed within base member. In the illustrated embodiment, proximal-most and distal-most stents 1756a,b are high frequency, low amplitude stents attached to the outside of graft material 1758, which can help improve the fit of spanning member 1750. The graft material 1758 may be attached to the outside of the stents 1756 other than the proximal-most and distal-most stents 1756a,b.

[0067] FIG 18A is an end view of a spanning member 1850 in a constrained (e.g., first) configuration and an expanded (e.g., second) configuration in accordance with an embodiment of the present technology. FIG 18B is a distal-facing end view of an aortic repair device 1800 including the spanning member 1850 of FIG 18A in accordance with an embodiment of the present technology. With reference to FIG 18B, the aortic repair device 1800 can include a base member 1810 having a body portion 1812 with a septum 1818 extending fully or partially therethrough. The septum 1818 is offset laterally within the body portion 1812 such that the septum 1818 divides the body portion 1812 into a primary lumen 1823 and a secondary lumen 1825, the secondary lumen 1825 having a smaller size than the primary lumen 1823. A stent 1830 is disposed within the secondary lumen 1825 .

[0068] 18A, the spanning member 1850 includes a graft material 1858 attached to a plurality of struts 1856 of a stent. The spanning member 1850 has a first diameter D1 in a constrained configuration and a second diameter D2 in an expanded configuration that is greater than the first diameter D1. The graft material 1858 is configured to be relatively loose or pouch-like in the constrained configuration and can be taut in the expanded configuration. In some embodiments, the second diameter D2 is between about 1.2 and 2.5 times (e.g., between about 1.3 and 2.0 times) the size of the first diameter D1. With joint reference to FIGS. 18A and 18B, in some embodiments, the diameter D1 is selected to be equal or approximately equal to the diameter of a target vessel (e.g., the aorta) into which the spanning member 1850 will be implanted such that the spanning member 1850 assumes the constrained configuration when deployed within the base member 1810. Thus, in some embodiments of the present technology, the loose graft material 1858 can help the spanning member 1850 to conform and seal around the circumference of the primary lumen 1823 without leaving a substantial gap (e.g., a leak path) through the main body portion 1812.

[0069] 19 is a distal facing end view of an aortic repair device 1900 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 1900 includes a base member 1910 having a body portion 1912 with a septum 1918 extending completely or partially therethrough. The septum 1918 is offset laterally within the body portion 1912 such that the septum 1918 divides the body portion 1912 into a primary lumen 1923 and a secondary lumen 1925, the secondary lumen 1925 having a smaller size than the primary lumen 1923. A stent 1930 is disposed within the secondary lumen 1925 and a spanning member 1950 is disposed within the primary lumen 1923. In the illustrated embodiment, both the stent 1930 and the spanning member 1950 have a D-shaped cross-sectional shape, and together they form a generally circular shape. The matching D-shaped cross-sectional shape can help improve the fit and seal of (i) spanning member 1950 in primary lumen 1923 and (ii) stent 1930 in secondary lumen 1925, thereby reducing leakage through main body portion 1912.

[0070] 20A and 20B are enlarged perspective side and distally facing end views, respectively, of a spanning member 2050 in accordance with an embodiment of the present technology. Referring together to FIGS. 20A and 20B, the spanning member 2050 includes a graft material 2058 attached to a plurality of stents 2056. The spanning member 2050 can further include a proximal end portion 2051 configured to be positioned within a lumen of a base member (such as, for example, the base member 810 described in detail above with reference to FIGS. 8A-8H). In the illustrated embodiment, the stents 2056 proximal to the proximal end portion 2051 are configured (e.g., shaped and sized) to form a recess 2037 such that the proximal end portion 2051 of the spanning member 2050 has, for example, a crescent or kidney bean cross-sectional shape. With additional reference to Figures 8A-8H, when spanning member 2050 is placed within primary lumen 823 of base member 810, recess 2037 can be positioned adjacent stent 830 and septum 818 and is shaped to generally match the shape of stent 830 and septum 818 such that spanning member 850 fits and seals around primary lumen 823.

[0071] 21 is a side perspective view of a spanning member 2150 in accordance with an embodiment of the present technology. In the illustrated embodiment, spanning member 2150 includes a proximal end portion 2151 configured to expand within and conform to a base member and a distal end portion 2153 configured to expand within and conform to a blood vessel (e.g., an aorta (e.g., aortic arch, descending thoracic aorta), etc.) and / or another base member. Spanning member 2150 includes a plurality of stents 2156 (e.g., including a first stent 2156a, a second stent 2156b, and a third stent 2156c, each individually identified) attached to a graft material 2158. The first stent 2156a defines a first (e.g., proximal) region 2155a of the spanning member 2150, the second stent 2156b defines a second (e.g., middle) region 2155b of the spanning member 2150, and the third stent 2156c defines a third (e.g., distal) region 2155c of the spanning member 2150. In some embodiments, the second stent 2156b can have a reduced diameter as compared to the first stent 2156a and / or the third stent 2156c such that the second region 2155b is narrower than the first region 2155a and / or the third region 2155c. In the illustrated embodiment, the graft material 2158 (i) does not extend proximally past the proximal-most of the first stents 2156a such that the spanning member 2150 has a proximal opening 2159a that follows the contour of the proximal-most of the first stents 2156a (e.g., arranged in a scalloped pattern), and the graft material 2158 (ii) does not extend distally past the distal-most of the third stents 2156c such that the spanning member 2150 has a distal opening 2159b that follows the contour of the distal-most of the third stents 2156c.That is, the proximal-most one of the first stents 2156a can be bare and exposed proximally from the graft material 2158, and the distal-most one of the third stents 2156c can be bare and exposed distally from the graft material 2158. In some aspects of the present technology, omitting graft material 2158 in this manner to form proximal openings 2159a and distal openings 2159b can improve the ability to position spanning member 2150 within one or more base members by reducing the risk of unintentional sealing in cases where spanning member 2150 is too long or positioned too far relative to the base member.

[0072] 22A and 22B are perspective end views of an aortic repair device 2200 in accordance with an embodiment of the present technology. In the illustrated embodiment, aortic repair device 2200 includes a base member 2210 having a body portion 2212 with a septum 2218 extending completely or partially therethrough and dividing body portion 2212 into a primary lumen 2223 and a secondary lumen 2225, the secondary lumen 2225 having a smaller size than the primary lumen 2223. In the illustrated embodiment, spanning member 2250 is disposed in the primary lumen 2223 and stent 2230 is disposed in the secondary lumen 2225.

[0073] 22B, if spanning member 2250 had significantly greater radial strength than stent 2230, spanning member 2250 could compress, flatten, and / or crush stent 2230, causing undue constriction and narrowing of secondary lumen 2225. Thus, in some embodiments, stent 2230 can be configured with a radial strength that resists undue compression by spanning member 2250.

[0074] 23 is a side view of a stent 2330 for use with aortic repair device 2200 of FIGS. 22A and 22B having increased radial strength (e.g., radial resistance), for example, in accordance with an embodiment of the present technology. In the illustrated embodiment, stent 2330 has a plurality of first struts 2332 having a zigzag or wavy shape (e.g., including a plurality of V-shaped portions) or a diamond shape (e.g., including a plurality of diamond-shaped portions) that extend circumferentially and that are interconnected by second struts 2334 that extend longitudinally. Stent 2330 can be made to have increased radial strength by (i) increasing the thickness of first struts 2332 and / or second struts 2334 in the radial direction, for example, by cutting (e.g., laser cutting) stent 2330 from a tube having a thicker wall; (ii) increasing the width of first struts 2332 and / or second struts 2334 in the longitudinal and / or circumferential directions; (iii) increasing the number of second struts 2334 (e.g., by including second struts 2334 between all or most of the apexes of adjacent first struts 2332); and / or (iv) increasing the "V angle" of first struts 2332 (e.g., by including a fewer number of V-shaped or diamond-shaped portions around the circumference of first strut 2332 and / or by including shorter V-shaped or diamond-shaped portions). 22A-23 together, increased radial strength can inhibit or even prevent spanning member 2550 from overly compressing stent 2330 and narrowing secondary lumen 2225.

[0075] FIG. 24 is a side view of the aorta illustrating aspects of an aortic repair device delivery procedure. As shown in FIG. 24, a first line 2402 illustrates where a tubular body of a base member implanted in the ascending aorta may lift away from and not conform to the aorta adjacent the aortic arch. Similarly, a second line 2404 in FIG. 24 illustrates where a tubular body of a base member implanted in the descending aorta may lift away from and not conform to the aorta adjacent the aortic arch. In such cases, the seal length of the base member may be reduced. In some embodiments, any of the aortic repair devices described herein can include features configured to promote conformance of the aortic repair device to the aorta (e.g., along a relatively curved portion of the aorta (e.g., the aortic arch, etc.)) to inhibit or even prevent the aortic repair device from lifting away from the wall of the aorta. For example, Figures 25A-27D illustrate additional embodiments of aortic repair devices including features that enhance conformance of a base member to an arched vessel wall, and Figures 87A-87C illustrate additional embodiments of aortic repair devices including features that enhance conformance of a spanning member to an arched vessel wall, in accordance with embodiments of the present technology. The various aortic repair devices can include certain features that are at least generally similar in structure and function (or identical in structure and function) to each other and / or to corresponding features of the aortic repair devices described in detail above with reference to Figures 3A-23, and can operate in a generally similar or identical manner to each other and / or to the aortic repair devices described above.

[0076] 25A-25E, for example, are side perspective views of various aortic repair devices 2500a-2500e, respectively, in accordance with embodiments of the present technology. In the illustrated embodiment, aortic repair devices 2500a-2500e each include a base member 2510 having (i) a body portion 2512 including a proximal end portion 2511 and a distal end portion 2513, and (ii) legs 2514 extending from the distal end portion 2513. Base members 2510 each include one or more stents 2526 coupled to graft material 2528. In some embodiments, body portion 2512 of any one of aortic repair devices 2500a-e can be flared outwardly at the proximal end portion 2511 and / or the distal end portion 2513. For example, the distal end portion 2513 can be flared outwardly along and / or generally along line F shown in each of Figures 25B-25E to improve the fit and / or seal of the main body portion 2512 within the aorta and, in particular, around curved portions of the aorta (e.g., proximate the aortic arch).

[0077] 25A and 25B together, the stents 2526 along the body portion 2512 include an individually identified intermediate stent 2526a positioned at and / or near the distal end portion 2513 between the body portion 2512 and the legs 2514 and having a V-pattern shape (e.g., including alternating proximal and distal apices). In the embodiment illustrated in FIG. 25A, one of the V-shaped portions of the intermediate stent 2526a and graft material thereon has been removed opposite the legs 2514 to form an opening or cutout 2519a (e.g., having a scalloped or scooped shape). 25B, the intermediate stent 2526a has a wedge portion 2519b that is opposite the leg 2514 and has a reduced amplitude relative to the remainder of the intermediate stent 2526a. In some aspects of the present technology, the cutouts 2519a and / or wedge portions 2519b can improve the fit and seal of the body portion 2512 within the aorta and especially around curved portions of the aorta (e.g., proximate the aortic arch).

[0078] 25C-D together, stents 2526 along body portion 2512 include individually identified proximal stents 2526a at and / or near proximal end portion 2511, distal stents 2526b at and / or near distal end portion 2513, and intermediate stents 2526c between proximal stents 2526a and distal stents 2526b. Stents 2526a-c each have a periodic V-pattern shape (e.g., including alternating proximal and distal apices). In the embodiment illustrated in FIG. 25C, the distal stent 2526b has a larger amplitude (e.g., length in a direction between apexes and between the proximal end portion 2511 and the distal end portion 2513 of the body portion 2512) and a smaller frequency than those of the proximal stent 2526a and the middle stent 2526c. Thus, the proximal end portion 2511 of the body portion 2512 (e.g., the entry portion) can have a relatively high frequency. In the embodiment illustrated in FIG. 25D, the proximal stent 2526a has a larger amplitude (e.g., length in a direction between apexes and between the proximal end portion 2511 and the distal end portion 2513 of the body portion 2512) and a smaller frequency than those of the distal stent 2526b and the middle stent 2526c. Thus, the distal end portion 2513 of the body portion 2512 (e.g., the exit portion) can have a relatively high frequency. In the embodiment depicted in Figure 25E, stents 2526a-c each have the same amplitude and frequency. In some aspects of the present technology, the placement of stents 2526a-c in one or more of Figures 25C-E can improve the fit and seal of body portion 2512 within the aorta, and particularly around curved portions of the aorta (e.g., proximate the aortic arch).

[0079] 26A and 26B are enlarged side views of a portion of an aortic repair device 2600 in a first position (e.g., undeployed position) and a second position (e.g., deployed position), respectively, in accordance with an embodiment of the present technology. Referring together to FIGS. 26A and 26B, aortic repair device 2600 includes a base member 2610 having a body portion 2612 including one or more stents 2626 coupled to graft material 2628. Similar to the embodiment shown in FIG. 25B, in the illustrated embodiment, stent 2626 has a V-pattern shape (e.g., including alternating proximal and distal apices) that decreases in amplitude in direction D. Direction D can be in a direction toward the interior wall of the aortic arch, which has less curvature (e.g., smaller radius of curvature, shorter length). In some aspects of the present technology, the decreasing amplitude of the stent 2626 can improve the fit and seal of the body portion 2612 within the aorta and especially around curved portions of the aorta (e.g., proximate the aortic arch). In some embodiments, the graft material 2628 and / or the stent 2626 can be pre-curved to have the second position shown in FIG. 26B.

[0080] 27A and 27B are enlarged side perspective and end perspective views, respectively, of an aortic repair device 2700 in accordance with an embodiment of the present technology. Referring together to FIGS. 27A and 27B, aortic repair device 2700 includes a base member 2710 having a body portion 2712, legs 2714 extending from body portion 2712, and a septum 2718 (FIG. 27B) extending fully or partially therethrough and dividing body portion 2212 into a primary lumen 2723 (FIG. 27B) and a secondary lumen 2725 (FIG. 27B), the secondary lumen 2725 having a smaller size than the primary lumen 2223. Base member 2710 includes one or more stents 2726 coupled to a graft material 2728. More specifically, with reference to Figure 27A, the stents 2726 along the body portion 2712 can include a first stent 2726a that extends generally circumferentially about the body portion 2712 and a second stent 2726b that extends generally or partially circumferentially about the secondary lumen 2725 (Figure 27B). As described in more detail below with reference to Figures 28A-33, the second stent 2726b can support and preserve the secondary lumen 2725 (Figure 27B) when the spanning member is deployed in the primary lumen 2723 (Figure 27B).

[0081] 27C is a perspective view of a first stent 2726a according to an embodiment of the present technology. With joint reference to FIGS. 27A and 27C, and similar to aortic repair device 2500b described in detail above with reference to FIG. 25B, first stent 2726a can have a V-pattern shape (e.g., including alternating proximal and distal apices) that varies (e.g., decreases) in amplitude in a direction away from leg 2714. In some embodiments, the portion of first stent 2726a positioned furthest from leg 2714 can also be angled outwardly at angle A (FIG. 27A) away from leg 2714. In some aspects of the present technology, the decreasing amplitude and / or outward angle A of first stent 2726a can improve the fit and seal of body portion 2712 within the aorta and especially around curved portions of the aorta (e.g., proximate the aortic arch). For example, FIG. 27D shows an aortic repair device 2700 implanted in the aorta and conforming to the wall of the ascending aorta proximal to the aortic arch, in accordance with an embodiment of the present technology.

[0082] 87A and 87B are side views of a spanning member 8750 of an aortic repair device in a first position (e.g., straight, extended position) and a second position (e.g., curved, relaxed position), respectively, in accordance with an embodiment of the present technology. Referring together to FIGS. 87A and 87B, in the illustrated embodiment, spanning member 8750 includes a plurality of stents 8756 attached to graft material 8758. The spanning member 8750 further has a leading (e.g., proximal) end portion 8751, a trailing (e.g., distal) end portion 8753, a first side portion 8754 configured to conform to a portion of the interior wall of the aortic arch having less curvature (e.g., smaller radius of curvature, shorter length), and a second side portion 8755 opposite the first side portion 8754 and configured to conform to a portion of the interior wall of the aortic arch having more curvature (e.g., larger radius of curvature, longer length). The first side portion 8754 can include features that cause the spanning member to passively shorten such that upon deployment ( FIG. 87B ), the spanning member 8750 assumes an arched shape. In some embodiments, for example, the stent 8756 has a V-pattern shape (e.g., including alternating proximal and distal apices) that decreases in amplitude in a direction from the second side portion 8755 to the first side portion 8754. In some aspects of the present technology, the decreasing amplitude of the stent 8756 can improve the fit and seal of the spanning member 8750 within the aorta, and particularly around curved portions of the aorta (e.g., proximate the aortic arch), in a manner similar to that described in detail above with reference to FIGS.

[0083] In some embodiments, the spanning member 8750 can include a tension member 8757 (e.g., a shortening member) positioned along at least a segment of the first side portion 8754. The tension member 8757 can be an elongate member that spans completely or partially between the leading end portion 8751 and the trailing end portion 8753 and can be configured to passively shorten the first side portion 8754 of the spanning member 8750, transitioning the spanning member 8750 from a straight first position shown in FIG. 87A to a curved second position shown in FIG. 87B. The tension members 8757 can be (i) elastic bands, cords, or other elements, (ii) springs (e.g., leaf springs, zigzag nitinol tension leaf springs, flattened coil springs), (iii) strips of elastic material (e.g., urethane, thermoplastic elastomer (TPE)), (iv) stent-like elements, and / or (v) others. The tension members 8757 can be secured to the inside of the graft material 8758 (e.g., to minimize wear on the tension members 8757) or secured to the outside of the graft material 8758 (e.g., to minimize potential embolism within the spanning member 8750). In some embodiments, the tension members 8757 are covered by a polymer or other material and / or inserted into seams / channels formed in the graft material 8758. In some embodiments, the tension member 8757 can include a plurality of individual springs or other shortening members positioned between individual ones of the stents 8756. FIG. 87C, for example, is an enlarged side view of a portion of the spanning member 8750, in accordance with an additional embodiment of the present technology. In the illustrated embodiment, the tension member 8757 includes one or more springs 8759 positioned between individual ones of the stents 8756.

[0084] 88A and 88B are side perspective views of a spanning member 8800 of an aortic repair device in a first position (e.g., straight, extended position) and a second position (e.g., curved, relaxed position), respectively, in accordance with an embodiment of the present technology. Referring together to FIGS. 88A and 88B, in the illustrated embodiment, spanning member 8850 includes a plurality of stents 8856 attached to graft material 8858. The spanning member 8850 further has a leading (e.g., proximal) end portion 8851, a trailing (e.g., distal) end portion 8853, a first side portion 8854 configured to conform to a portion of the inner wall of the aortic arch having less curvature (e.g., smaller radius of curvature, shorter length), and a second side portion 8855 opposite the first side portion 8854 and configured to conform to a portion of the inner wall of the aortic arch having a greater curvature (e.g., larger radius of curvature, longer length).

[0085] The first side portion 8854 includes a tension member 8857 including a plurality of individual elastic (e.g., Lycra) fibers that span between adjacent ones of the stents 8856, which passively shortens the first side portion 8854 when the spanning member 8850 is unconstrained, causing the spanning member 8850 to assume an arched shape upon deployment (FIG. 88B). For example, in the illustrated embodiment, the tension member 8857 can include six of the elastic fibers (also referred to as "elastic components"), one positioned between each adjacent pair of the seven illustrated stents 8856. In some embodiments, a greater number of elastic fibers can be positioned between adjacent pairs of the stents 8856. The elastic fibers of the tension member 8857 can be sewn onto the exterior of the graft material 8858 at the apex (or another portion) of the stent 8856 such that the elastic members pull the stents 8856 toward each other along the first side portion 8854. The tension member 8857 can be stretched into a straight first position (FIG. 88A) for loading into a delivery catheter in a cylindrical configuration. Upon deployment, the tension member 8857 can cause the spanning member 8850 to assume a curved second position (FIG. 88B).

[0086] In some embodiments, the tension member 8857 pulls some or all of the stents 8856 toward and at least partially over / under an adjacent one of the stents 8856. Thus, the first side portion 8854 can have a series of steps (e.g., rises and falls) therealong. In some embodiments, such overlap can resemble a "shingle" pattern, in which the overlap of adjacent stents 8856 occurs in a consistent pattern. For example, with respect to adjacent ones of the stents 8856, the tension member 8857 can consistently pull the leading one of the stents 8856 toward and / or over the trailing one of the stents 8856. Such a consistent pattern of overlap ("shingling") can promote consistent blood flow through the spanning member 8850.

[0087] The elastic fibers of the tension member 8857 can be secured between adjacent ones of the stents 8856 in a variety of arrangements. FIG. 88C, for example, is an enlarged side view of a portion of a spanning member 8850 illustrating two different potential attachments of the elastic fibers of the tension member 8857, in accordance with an embodiment of the present technology. In the illustrated embodiment, a pair of first elastic fibers 8859a of the tension member 8857 are secured via knots to adjacent apexes of an adjacent pair of stents 8856 (e.g., in an apex-to-apex arrangement between individually identified first stent 8856a and second stent 8856b). Additionally, the pair of second elastic fibers 8859b of the tension member 8857 are secured via knots to the apex of one of the adjacent pair of stents 8856 and to the same base of the other of the adjacent pair of stents 8856 (e.g., in an apex-to-base arrangement between the second stent 8856b and a separately identified third stent 8856b). In other embodiments, the elastic fibers of the tension member 8857 can be secured to the stent 8856 in other manners.

[0088] In various embodiments, one or more tension members can be incorporated into other components of the aortic repair devices described herein. For example, FIGS. 89A and 89B are side perspective views of a base member 8910 of an aortic repair device in a first position (e.g., straight, extended) and a second position (e.g., curved, relaxed), respectively, in accordance with an embodiment of the present technology. Referring together to FIGS. 89A and 89B, the base member 8910 has a body portion 8912 and legs 8914, where the body portion 8912 is configured to be implanted in the aorta and the legs 8914 extend from the body portion 8912 and are configured to be implanted in a bifurcation vessel. The base member 8910 includes a plurality of stents 8926 attached to a graft material 8928. The main body portion 8912 further includes a first side portion 8921 and a second side portion 8922, the first side portion 8921 being configured to conform to a portion of the inner wall of the aortic arch having less curvature (e.g., smaller radius of curvature, shorter length), and the second side portion 8922 being opposite the first side portion 8921 and configured to conform to a portion of the inner wall of the aortic arch having a greater curvature (e.g., larger radius of curvature, longer length).

[0089] In the illustrated embodiment, the first side portion 8921 of the body portion 8912 includes a tension member 8927 including a plurality of individual elastic (e.g., Lycra) fibers that span between adjacent ones of the stents 8926 along the body portion 8912, which passively shortens the first side portion 8921 when the base member 8910 is unconstrained, causing the body portion 8912 to assume an arched shape upon deployment (FIG. 89B). For example, in the illustrated embodiment, the tension member 8927 can include two of the elastic fibers (one positioned between each adjacent pair of the three illustrated stents 8926 along the body portion 8912). The elastic fibers of the tension member 8957 can be sewn onto the exterior of the graft material 8928 at the apexes (or other portions) of the stents 8926 such that the elastic members draw the stents 8926 toward each other along the first side portion 8921. In some embodiments, the elastic fibers of the tension member 8957 can be secured to the stent 8926 in the same or similar manner (e.g., apex-to-apex, apex-to-base, and / or other arrangements) as described in detail above with reference to FIG. 88C. The tension member 8927 can be stretched in a straight first position (FIG. 89A) for loading into a delivery catheter in a cylindrical configuration. Upon deployment, the body portion 8912 of the base member 8910 can assume a curved second position (FIG. 88B). In some embodiments, in the curved second position (FIG. 89B), the tension member 8927 pulls some or all of the stents 8926 toward and at least partially over / under an adjacent one of the stents 8926 such that the first side portion 8921 has a stepped "roof shingle" pattern, as described in detail above with reference to FIG. 88B.

[0090] In some embodiments, tensioning members for use in an aortic repair device can include inelastic fibers, sutures, and / or structures that are arranged to passively shorten a portion of the aortic repair device. For example, FIGS. 90A and 90B are close-up views of a pair of stents 9026 (including a first stent 9026a and a second stent 9026b, each identified individually) of a component of an aortic repair device 9000 (e.g., any of the base members and / or spanning members described herein) in a free state and a compacted state, respectively, in accordance with an embodiment of the present technology. In the illustrated embodiment, the stents 9026 are identical and positioned in phase with one another (e.g., with their apices aligned). FIGS. 90C and 90D are close-up views of the stent 9026 in a free state and a compacted state, respectively, after one or more tensioning sutures 9027 are attached to the stent 9026 in accordance with an embodiment of the present technology. The tensioning suture 9027 can include typical surgical suture material and can be inelastic. In the illustrated embodiment, the tensioning suture 9027 connects a single apex of the first stent 9026a to a pair of bases of the second stent 9026b, reducing the distance between the stents 9026 in the free state. Thus, in the free state, the tensioning suture 9027 can selectively shorten a portion (e.g., a side portion) of the aortic repair device 9000 proximate the tensioning suture 9027, for example, to better conform the aortic repair device 9000 to the curvature in the aorta. In the compacted state, the tensioning suture 9027 can move (e.g., fold, pivot about the apex of the first stent 9026a) to allow the aortic repair device 9000 to return to an elongated cylindrical state. In some embodiments, the tensioning sutures 9027 can connect the stents 9026 together in different ways.For example, tensioning sutures 9027 can connect one or more apexes of a first stent 9026a to one or more remote apexes 9029 of a second stent 9026b, decreasing the distance between the stents 9026 in the free state and increasing the nesting / shingling between them. Figures 90E and 90F are schematic side views of an aortic repair device 9000 in a free (e.g., bent) and compacted (e.g., straight) state, respectively, in accordance with an embodiment of the present technology.

[0091] In some embodiments, the stents 9026 can have different configurations (e.g., shapes, sizes, patterns) to vary the amount of nesting between them or to otherwise affect the shortening of the aortic repair device 9000. For example, FIGS. 91A and 91B are close-up views of a stent 9026 in a free and compacted state, respectively, where a second stent 9026b has alternating stent apex heights, in accordance with additional embodiments of the present technology. Notably, the second stent 9026b can have a smaller amplitude at the apexes / bases where the tensioning sutures 9027 connect to further increase the amount of nesting between the stents 9026 (and the corresponding shortening and arching of the aortic repair device 9000).

[0092] 28A-33 illustrate additional embodiments of aortic repair devices including a base member having integrated features for supporting the septum and secondary leg lumens, e.g., to inhibit compression of the secondary leg lumens and to maintain blood flow through the secondary leg lumens when the spanning member is placed within the base member, in accordance with embodiments of the present technology. Such features can replace the need for a separate support stent to be implanted within the base member. The various aortic repair devices can include some features that are at least generally similar in structure and function (or identical in structure and function) to each other and / or to corresponding features of the aortic repair devices described in detail above with reference to FIGS. 3A-27D and can operate in a generally similar or identical manner to each other and / or to the aortic repair devices described above.

[0093] 28A and 28B, for example, are perspective and end views, respectively, of an aortic repair device 2800 in accordance with an embodiment of the present technology. Referring together to FIGS. 28A and 28B, aortic repair device 2800 includes a base member 2810 having (i) a body portion 2812 defining a primary lumen 2823 and (ii) legs 2814 defining secondary lumens 2825. In the illustrated embodiment, body portion 2812 and legs 2814 are separate stent grafts secured together, for example, via stitching. More specifically, body portion 2812 includes body stent 2826a coupled to body graft material 2828a, and legs 2814 includes leg stent 2826b coupled to leg graft material 2828b. The body portion and leg stents 2826a-b can be formed from the same material and can have a similar shape (e.g., including a circumferential V-pattern), and the body portion and leg graft material 2828a-b can be formed from the same material (e.g., fabric). The leg graft material 2828b can act as a septum and define a secondary lumen 2825. In some embodiments, the leg stents 2826b extend entirely circumferentially around the secondary lumen 2825, while in other embodiments (e.g., as described below with reference to FIGS. 32A-32D), the leg stents 2826b can extend only partially circumferentially around the secondary lumen 2825.

[0094] The leg stents 2826b can provide increased radial support for the leg graft material 2828b when the stent 830 is not deployed in the secondary lumen 825, as compared to an unsupported septum (such as, for example, septum 818 shown in FIGS. 8A-8H). Thus, in some aspects of the present technology, the leg stents 2826b can help preserve the cross-sectional flow area of ​​the secondary lumen 2825 when the spanning member is deployed in the primary lumen 2823. Moreover, the leg stents 2826b are integral with the base member 2810, such that a separate step or procedure is not required to implant the leg stents 2826b therein (as compared, for example, to the deployment of the stent 830 described in detail above with reference to FIGS. 8A-8H).

[0095] 29A and 29B are perspective end views of an aortic repair device 2900 in accordance with an embodiment of the present technology. In FIG. 29B, the aortic repair device 2900 is deployed within a lumen 2902 (such as, for example, a portion of the aorta). Referring together to FIGS. 29A and 29B, the aortic repair device 2900 includes a base member 2910 having a body portion 2912 with a septum 2918 extending fully or partially therethrough and dividing the body portion 2912 into a primary lumen 2923 and a secondary lumen 2925, the secondary lumen 2925 having a smaller size than the primary lumen 2923. In the illustrated embodiment, the body portion 2912 includes a body stent 2926 coupled to a graft material 2928. In the illustrated embodiment, the base member 2910 further includes one or more secondary lumen stents 2929 positioned within the secondary lumen 2925. In some embodiments, the secondary lumen stents 2929 extend generally circumferentially around the secondary lumen 2925 and are coupled to the graft material 2928 and / or the septum 2918, for example, via stitching. The secondary lumen stents 2929 can be self-expanding and can have a V-pattern or other shape. In some embodiments, the secondary lumen stent 2929 has a circular cross-sectional shape. In other embodiments, the secondary lumen stent 2929 has a non-circular cross-sectional shape (e.g., oval or other shape, etc.). In some embodiments, as shown in FIG. 29B, the secondary lumen stent 2929 bows outwardly toward the primary lumen 2223 when the aortic repair device 2900 is compressed within the lumen 2902.

[0096] The secondary lumen stent 2929 can provide increased radial support for the septum 2918 when the stent 830 is not deployed within the secondary lumen 825, as compared to an unsupported septum (such as, for example, septum 818 shown in FIGS. 8A-8H ). Thus, in some aspects of the present technology, the secondary lumen stent 2929 can help preserve the cross-sectional flow area of ​​the secondary lumen 2925 when a spanning member is deployed within the primary lumen 2923. For example, the secondary lumen stent 2929 can resist and / or match the radial force of a spanning member deployed within the primary lumen 2923, inhibiting displacement of the septum 2918 and maintaining the cross-sectional flow area of ​​the secondary lumen 2925. The outward bowing of the secondary lumen stent 2929 can further resist compression from the spanning member. In some embodiments, the secondary lumen stent 2929 can be sufficiently stiff to inhibit compression of the secondary lumen 2925, while also being flexible enough to conform with the spanning member to sufficiently inhibit significant guttering or opening between the spanning member and the septum 2918. In additional aspects of the present technology, the secondary lumen stent 2929 is integral with the base member 2910 such that a separate step or procedure is not required to implant the secondary lumen stent 2929 therein (e.g., as compared to the placement of stent 830 described in detail above with reference to FIGS. 8A-8H).

[0097] 30A and 30B are perspective end views of an aortic repair device 3000 in accordance with an embodiment of the present technology. In FIG. 30B, the aortic repair device 3000 is placed within a lumen 3002 (such as, for example, a portion of the aorta). Referring together to FIGS. 30A and 30B, the aortic repair device 3000 includes a base member 3010 having a body portion 3012 with a septum 3018 extending fully or partially therethrough and dividing the body portion 3012 into a primary lumen 3023 and a secondary lumen 3025, the secondary lumen 3025 having a smaller size than the primary lumen 3023. In the illustrated embodiment, the body portion 3012 includes a body stent 3026 coupled to a graft material 3028. The base member 3010 can further include one or more secondary lumen stents 3029 positioned within the secondary lumen 3025. In some embodiments, the secondary lumen stents 3029 extend generally circumferentially around the secondary lumen 3025 and are coupled to the graft material 3028 and / or the septum 3018, for example, via stitching.

[0098] 30C and 30D are perspective and end views, respectively, of one of the secondary lumen stents 3029, in accordance with an embodiment of the present technology. With reference to FIGS. 30C and 30D together, the secondary lumen stent 3029 can have a D-shaped cross-sectional shape including a generally flat portion 3021 and a generally curved portion 3027. The secondary lumen stent 3029 can further include a V-pattern extending circumferentially around the flat portion 3021 and the curved portion 3027, as shown in FIG. 30C. With reference to FIGS. 30A-30D together, the flat portion 3021 of the secondary lumen stent 3029 can be positioned adjacent to and / or coupled to the septum 3018, and the curved portion 3027 of the secondary lumen stent 3029 can be positioned adjacent to and / or coupled to the graft material 3028 of the body portion 3012. Thus, in the unconstrained and constrained positions shown in Figures 30A and 30B, respectively, the septum 3018 can extend generally linearly between the primary lumen 3023 and the secondary lumen 3025.

[0099] Similar to the embodiment described in detail above with reference to FIGS. 28A-29C, the secondary lumen stent 3029 can provide increased radial support for the septum 3018 when the stent 830 is not deployed within the secondary lumen 825, as compared to an unsupported septum (such as septum 818 shown in FIGS. 8A-8H ). Thus, in some aspects of the present technology, the secondary lumen stent 3029 can help preserve the cross-sectional flow area of ​​the secondary lumen 3025 when a spanning member is deployed within the primary lumen 3023. For example, FIGS. 30E and 30F are perspective end views of an aortic repair device 3000 with a spanning member 3050 deployed within the primary lumen 3023. In FIG. 30F, the aortic repair device 3000 is deployed within the lumen 3002. 30E and 30F together, the secondary lumen stent 3029 resists and / or matches the radial force of the spanning member 3050 to inhibit displacement of the septum 3018 and maintain the cross-sectional flow area of ​​the secondary lumen 3025. In some embodiments, the secondary lumen stent 3029 can be sufficiently stiff to inhibit compression of the secondary lumen 3025 while also being flexible enough to conform with the spanning member 3050 to sufficiently inhibit significant grooves or openings between the spanning member 3050 and the septum 3018. Moreover, the flat portion 3021 of the secondary lumen stent 3029 can maintain the septum 3018 in a generally flat or linear configuration such that the spanning member 3050 can conform thereto with minimal grooves or openings between the septum 3018 and the spanning member 3050. Referring together to Figures 30A-30F, in an additional aspect of the present technology, the secondary lumen stent 3029 is integral with the base member 3010 such that no separate step or procedure is required to implant the secondary lumen stent 3029 therein (e.g., as compared to the placement of the stent 830 described in detail above with reference to Figures 8A-8H).

[0100] 31A and 31B are perspective end views of an aortic repair device 3100 in accordance with an embodiment of the present technology. In FIG. 31B, the aortic repair device 3100 is placed within a first lumen 3102 (such as, for example, a portion of the aorta). Referring together to FIGS. 31A and 31B, the aortic repair device 3100 includes a base member 3110 having a body portion 3112 with a septum 3118 extending fully or partially therethrough and dividing the body portion 3112 into a primary lumen 3123 and a secondary lumen 3125, the secondary lumen 3125 having a smaller size than the primary lumen 3123. In the illustrated embodiment, the body portion 3112 includes a body stent 3126 coupled to a graft material 3128. In the illustrated embodiment, the base member 3110 further includes one or more secondary lumen stents 3129 positioned within the secondary lumen 3125. In some embodiments, the secondary lumen stents 3129 extend generally circumferentially around the secondary lumen 3125 and are coupled to the graft material 3128 and / or the septum 3118, for example, via stitching.

[0101] 31C and 31D are perspective and end views, respectively, of one of the secondary lumen stents 3129, according to an embodiment of the present technology. Referring together to FIG. 31C and FIG. 31D, the secondary lumen stent 3129 can have an arched D-shaped cross-sectional shape including a curved first portion 3121 and a curved second portion 3127. The curved first portion 3121 can have a radius of curvature greater than the radius of curvature of the curved second portion 3127. That is, the curved first portion 3121 can be relatively flatter than the curved second portion 3127. The curved first portion 3121 can also be referred to as a spacer and / or an arched portion, etc. The secondary lumen stent 3129 can further include a V-pattern extending circumferentially around the curved first portion 3121 and the curved second portion 3129, as shown in FIG. 31C. 31A-31D together, a curved first portion 3121 of the secondary lumen stent 3129 can be positioned adjacent to and / or coupled to the septum 3118, and a curved second portion 3127 of the secondary lumen stent 3129 can be positioned adjacent to and / or coupled to the graft material 3128 of the body portion 3112. Thus, in the unconstrained and constrained positions shown in Figures 31A and 31B, respectively, the septum 3118 can be curved outward (e.g., bowed outward) along the curved first portion 3121 between the primary lumen 3123 and the secondary lumen 3125.

[0102] 28A-30F, the secondary lumen stent 3129 can provide increased radial support for the septum 3118 when the stent 830 is not deployed in the secondary lumen 825, as compared to an unsupported septum (such as, for example, septum 818 shown in FIGS. 8A-8H ). Thus, in some aspects of the present technology, the secondary lumen stent 3129 can help preserve the cross-sectional flow area of ​​the secondary lumen 3125 when a spanning member is deployed in the primary lumen 3123. For example, FIGS. 31E-31G are perspective end views of an aortic repair device 3100 with a spanning member 3150 deployed in the primary lumen 3123, in accordance with an embodiment of the present technology. In Figure 31E, the aortic repair device 3100 is unconstrained, in Figure 31F the aortic repair device 3100 is placed in a first lumen 3102 having a first diameter (e.g., 31 millimeters), and in Figure 31G the aortic repair device 3100 is placed in a second lumen 3104 having a second diameter (e.g., 29 millimeters) smaller than the first diameter. Referring together to Figures 31E-31G, the secondary lumen stent 3129 resists and / or matches the radial force of the spanning member 3150, inhibiting displacement of the septum 3118 and maintaining the cross-sectional flow area of ​​the secondary lumen 3125. In some embodiments, the secondary lumen stent 3129 can be sufficiently stiff to inhibit compression of the secondary lumen 3125 while also being flexible enough to conform with the spanning member 3150 to sufficiently inhibit significant grooves or openings between the spanning member 3150 and the septum 3118. Referring together to FIGS. 31A-31G, in an additional aspect of the present technology, the secondary lumen stent 3129 is integral with the base member 3110 such that a separate step or procedure is not required to implant the secondary lumen stent 3129 therein (e.g., as compared to the placement of stent 831 described in detail above with reference to FIGS. 8A-8H).

[0103] 31G, as the lumen 3104 becomes smaller, further limiting the overall radial expansion of the aortic repair device 3100, the curved first portion 3121 of the secondary lumen stent 3129 can bow and / or bend outwardly further (e.g., become more curved, more convex) to maintain the cross-sectional flow area of ​​the secondary lumen 3125. In some embodiments, the structure defining the first lumen 3123 can be relatively more compressible (e.g., less resistant to compression) than the structure defining the second lumen 3125, such that the ratio of the cross-sectional flow area of ​​the first lumen 3123 to the cross-sectional flow area of ​​the secondary lumen 3125 decreases when the aortic repair device 3100 is radially compressed, regardless of whether the spanning member 3150 is disposed within the primary lumen 3123. For example, Figures 31H-31L are perspective end views of an aortic repair device 3100 illustrating increasing radial compression of the aortic repair device 3100, in accordance with an embodiment of the present technology. Specifically, referring together to Figures 31H-31L, the aortic repair device 3100 is placed within a lumen 3106 (such as, for example, a portion of the aorta) having a diameter that progressively decreases from Figure 31H to Figure 31L. In the illustrated embodiment, the diameter of the lumen 3106 (e.g., 20 mm) is 20% smaller in Figure 31L than the diameter of the lumen 3106 in Figure 31H (e.g., 24 mm), and progressively decreases between Figures 31I-31K (e.g., from 23 mm to 22 mm to 21 mm, respectively). In some embodiments, the aortic repair device 3100 can have a diameter that matches the diameter of the lumen 3106 shown in FIG. 31H (e.g., 24 mm) such that the aortic repair device 3100 is not oversized for the lumen 3106.The structure defining the secondary lumen 3125 is relatively less compressible than the first lumen 3123, such that the ratio of the cross-sectional flow area of ​​the secondary lumen 3125 to the cross-sectional flow area of ​​the primary lumen 3123 increases from FIG. 31H to FIG. 31L as the radial expansion of the aortic repair device 3100 is further restricted by the lumen 3106 (e.g., the inner diameter of the aorta). Thus, in some embodiments of the present technology, the secondary lumen 3125 is well preserved throughout the range of oversizing of the aortic repair device 3100 relative to the lumen 3106.

[0104] 32A is a perspective end view of an aortic repair device 3200 placed within a lumen 3202 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 3200 includes a base member 3210 having a body portion 3212 with a septum 3218 extending fully or partially therethrough and dividing the body portion 3212 into a primary lumen 3223 and a secondary lumen 3225, the secondary lumen 3225 having a smaller size than the primary lumen 3223. In the illustrated embodiment, the body portion 3212 includes a body stent 3226 coupled to a graft material 3228. In the illustrated embodiment, the base member 3210 further includes one or more secondary lumen stents 3229 positioned within the secondary lumen 3225. In some embodiments, the secondary lumen stent 3229 extends only partially circumferentially around the secondary lumen 3225 and is coupled to the graft material 3228 and / or the septum 3218, for example, via stitching. More specifically, FIG. 32B is an end view of one of the secondary lumen stents 3229 in accordance with an embodiment of the present technology. In the illustrated embodiment, the secondary lumen stent 3229 can extend only partially around the longitudinal axis L (FIG. 32A) of the secondary lumen 3225 and can have a curved shape (e.g., a semicircular shape or an arched shape, etc.). The secondary lumen stent 3229 can further include a V-pattern extending circumferentially therealong. Referring together to FIGS. 32A and 32B, the secondary lumen stent 3229 can be positioned adjacent to and / or coupled to the septum 3218. Thus, in the unconstrained position (not shown) and in the constrained position shown in FIG. 32A, the septum 3218 can be curved outward (e.g., bowed outward) between the primary lumen 3223 and the secondary lumen 3225 along the secondary lumen stent 3229.In some embodiments of the present technology, the secondary lumen stent 3229 can reduce the overall delivery profile of the base member 3210 by omitting the secondary lumen stent 3229 adjacent to the main body stent 3226 (e.g., in cases where the main body stent 3226 provides an outward sealing force to the main body 3212).

[0105] Similar to the embodiment described in detail above with reference to FIGS. 28A-31G, the secondary lumen stent 3229 can provide increased radial support for the septum 3218 when the stent 830 is not deployed within the secondary lumen 825, as compared to an unsupported septum (such as septum 818 shown in FIGS. 8A-8H ). Thus, in some aspects of the present technology, the secondary lumen stent 3229 can help preserve the cross-sectional flow area of ​​the secondary lumen 3225 when the spanning member is deployed within the primary lumen 3223. For example, FIGS. 32C and 32D are perspective end views of the aortic repair device 3200 with the spanning member 3250 deployed within the primary lumen 3223. In FIG. 32C, the aortic repair device 3200 is unconstrained, and in FIG. 32D, the aortic repair device 3200 is deployed within the lumen 3202. 32C and 32D together, the secondary lumen stent 3229 resists and / or matches the radial force of the spanning member 3250 to inhibit displacement of the septum 3218 and maintain the cross-sectional flow area of ​​the secondary lumen 3225. In some embodiments, the secondary lumen stent 3229 can be sufficiently stiff to inhibit compression of the secondary lumen 3225 while also being flexible enough to conform with the spanning member 3250 to sufficiently inhibit significant grooves or openings between the spanning member 3250 and the septum 3218. Referring together to FIGS. 32A-32D, in an additional aspect of the present technology, the secondary lumen stent 3229 is integral with the base member 3210 such that a separate step or procedure is not required to implant the secondary lumen stent 3229 therein (e.g., as compared to the placement of the stent 832 described in detail above with reference to FIGS. 8A-8H).

[0106] 33 is a cross-sectional view of an aortic repair device 3300 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 3300 includes a base member 3310 including one or more body stents 3326 defining a primary lumen 3323 and one or more secondary lumen stents 3329 defining a secondary lumen 3325. In the illustrated embodiment, the secondary lumen stent has an arched D-shaped cross-sectional shape including a curved first portion 3321 and a curved second portion 3327. The curved first portion 3321 of the secondary lumen stent 3329 can be positioned adjacent to and / or coupled to a septum of the base member 3310 and the curved second portion 3327 of the secondary lumen stent 3329 can be positioned adjacent to and / or coupled to the graft material of the body of the base member 3310. In some embodiments of the present technology, the secondary lumen stent 3329 resists and / or matches the radial force of a spanning member placed within the primary lumen 3323, inhibiting septum displacement and maintaining the cross-sectional flow area of ​​the secondary lumen 3325.

[0107] In the illustrated embodiment, the body stent 3326 can extend only partially around the longitudinal axis L of the primary lumen 3323 and can have a curved shape (e.g., a circular shape, etc.). The body stent 3326 and the curved second portion 3327 of the secondary lumen stent 3329 can together define a constant or near-constant circumferential stent structure around the base member 3310, for example, to provide an outward sealing force when the base member 3310 is implanted in the aorta. Moreover, in some aspects of the present technology, the arrangement of the body stent 3326 and the secondary lumen stent 3329 can reduce the overall delivery profile of the base member 3310 (e.g., so that separate stents do not overlap) by omitting a portion of the body stent 3326 adjacent to the curved second portion 3327 of the secondary lumen stent 3329.

[0108] 28A-33 together, any of the secondary lumen stents can be made stronger (e.g., to have increased radial force and / or increased crush resistance, etc.) by increasing the wire diameter of the secondary lumen stent and / or by heat treating (e.g., shape setting) the wire for a longer duration and / or at a higher temperature. Increasing the strength of the secondary lumen stent can help improve the ability of the secondary lumen stent to preserve the cross-sectional flow area of ​​the secondary lumen during radial compression and / or when a spanning member is deployed within the primary lumen.

[0109] 34A-40C illustrate additional embodiments of aortic repair devices including a base member having a stent configured to inhibit or permit longitudinal compression of the base member in accordance with embodiments of the present technology. The various aortic repair devices can include certain features that are at least generally similar in structure and function (or identical in structure and function) to each other and / or to corresponding features of the aortic repair devices described in detail above with reference to FIGS. 3A-33 and can operate in a generally similar or identical manner to each other and / or to the aortic repair devices described above.

[0110] For example, Figures 34A and 34B are side perspective views of aortic repair device 3400 in a longitudinally elongated position and a longitudinally compressed position, respectively, in accordance with an embodiment of the present technology. Similarly, Figures 35A and 35B are side perspective views of aortic repair device 3500 in a longitudinally elongated position and a longitudinally compressed position, respectively, in accordance with an embodiment of the present technology. Aortic repair device 3400 and aortic repair device 3500 can include several features that are generally similar or identical. For example, referring together to Figures 34A-35B, both aortic repair device 3400 and aortic repair device 3500 include a base member 3410 having a body portion 3412, legs 3414 extending from body portion 3412, and a septum (obscured in Figures 34A-35B) that extends completely or partially through body portion 3412 and divides body portion 3412 into a primary lumen and a secondary lumen. Base member 3410 includes one or more stents 3426 coupled to graft material 3428. More specifically, the stents 3426 along the body portion 3412 can include a first stent 3426a (e.g., a proximal stent) and a second stent 3426b (e.g., a distal stent), each having a periodic V-pattern shape including alternating proximal and distal apexes 3421 and 3423. In some embodiments, the first stent 3426a and the second stent 3426b are identical, e.g., having the same size and number of proximal and distal apexes 3421 and 3423, respectively.

[0111] 34A and 34B together, the proximal apex 3421 of the first stent 3426a is circumferentially aligned or generally aligned with the proximal apex 3421 of the second stent 3426b. Similarly, the distal apex 3423 of the first stent 3426a is circumferentially aligned or generally aligned with the distal apex 3423 of the second stent 3426b. That is, the first stent 3426a and the second stent 3426b can be positioned in phase or substantially in phase. As shown in FIG. 34B, for example, this positioning of the stents 3426a-b can allow the body portion 3412 to compress longitudinally when the aortic repair device 3400 is implanted in the aorta and is subjected to forces from blood flow through the aorta. For example, the distal apex 3423 of a first stent 3426a can move toward the distal apex 3423 of a second stent 3426b while folding or otherwise compressing the graft material 3428 therebetween. In some embodiments, the longitudinal compression (e.g., the difference between the length L1 of the body portion 3412 in the longitudinally elongated position shown in FIG. 34A and the length L2 of the body portion 3412 in the longitudinally compressed position shown in FIG. 34B) can be about 40%, less than about 40%, about 20%, less than about 20%, etc.

[0112] 35A and 35B together, the proximal apex 3421 of the first stent 3426a is circumferentially aligned or generally aligned with the distal apex 3423 of the second stent 3426b. Similarly, the distal apex 3423 of the first stent 3426a is circumferentially aligned or generally aligned with the proximal apex 3421 of the second stent 3426b. That is, the first stent 3426a and the second stent 3426b can be positioned out of phase (e.g., 180 degrees out of phase) or substantially out of phase. As shown in FIG. 35A, in the longitudinally elongated position, the distal apex 3423 of the first stent 3426a can be spaced apart from the corresponding proximal apex 3421 of the second stent 3426b by a gap G. The gap G can provide the body portion 3412 with increased flexibility because the body portion 3412 can bend along the gap G where the stents 3426a-b are omitted. As shown in FIG. 35B, for example, when the aortic repair device 3400 is implanted in the aorta and is subjected to forces from blood flow through the aorta, this arrangement of the stents 3426a-b can allow the body portion 3412 to compress longitudinally. For example, the distal apex 3423 of the first stent 3426a can move toward, under and / or over the proximal apex 3421 of the second stent 3426b (e.g., reducing or eliminating the gap G), folding or otherwise compressing the graft material 3428 therebetween. In some embodiments, the longitudinal compression (e.g., the difference between the length L1 of the body portion 3412 in the longitudinally elongated position shown in FIG. 35A and the length L2 of the body portion 3412 in the longitudinally compressed position shown in FIG. 35B) can be about 20%.

[0113] 36A and 36B are side perspective views of an aortic repair device 3600 in a longitudinally elongated position from different circumferential perspectives in accordance with an embodiment of the present technology. FIG. 36C is a side perspective view of an aortic repair device 3600 in a longitudinally compressed position in accordance with an embodiment of the present technology. With reference to FIGS. 36A-36C, the aortic repair device 3600 can include a base member 3610 having a body portion 3612, legs (obscured in FIGS. 36A-36C) extending from the body portion 3612, and a septum (obscured in FIGS. 36A-36C) extending completely or partially through the body portion 3612 and dividing the body portion 3612 into a primary lumen and a secondary lumen. The base member 3610 includes one or more stents 3626 coupled to a graft material 3628. More specifically, the stents 3626 along the body portion 3612 can include a first stent 3626a (e.g., a proximal stent) and a second stent 3626b (e.g., a distal stent), each having a periodic V-pattern shape including alternating proximal and distal apexes 3621 and 3623. In the illustrated embodiment, the first stent 3626a and the second stent 3626b each have a different number of proximal and distal apexes 3621 and 3623 (e.g., different frequencies).

[0114] More specifically, Figure 36D is a plan view of a first stent 3626a and a second stent 3626b in accordance with an embodiment of the present technology. In the illustrated embodiment, the first stent 3626a includes eight V-shaped portions such that the first stent 3626a has eight of the proximal apices 3621 and eight of the distal apices 3623, and the second stent 3626b includes six V-shaped portions such that the second stent 3626b has six of the proximal apices 3621 and six of the distal apices 3623. In other embodiments, the stents 3626a-b can have different numbers of proximal apices 3621 and / or distal apices 3623. In the illustrated embodiment, the first stent 3426a and the second stent 3426b each have a regular pattern such that their V-shaped portions are equally spaced apart from one another. Thus, a first subset of the distal apexes 3623 of the first stent 3626a can be circumferentially aligned with the proximal apexes 3621 of the second stent 3626b, while a second subset of the distal apexes 3623 of the first stent 3626a can be circumferentially offset from the proximal apexes 3621 of the second stent 3626b. In the illustrated embodiment, the first subset includes two of the distal apices 3623 of the first stent 3626a, and the second subset includes six of the distal apices 3623 of the first stent 3626a (FIG. 36D illustrates a wraparound view, such that the distal apices 3623 of the first stent 3626a at the right and left ends of the first stent 3636a represent the same one of the distal apices 3623 of the first stent 3626a). For example, the distal apices 3623 of the first stent 3626a, which are positioned approximately 180 degrees apart (e.g., on opposite sides of the body portion 3612 shown in FIGS. 36A-36C), are circumferentially aligned with corresponding ones of the proximal apices 3621 of the second stent 3626b.In other embodiments, the number of distal apices 3623 of the first stent 3626a in the first and second subsets can differ, for example, based on the total number of apices of the stents 3626a-b. Further, in the illustrated embodiment, aligned ones of the distal apices 3623 of the first stent 3626a and the proximal apices 3621 of the second stent 3626b can abut one another such that they are not separated by a gap.

[0115] 36A-36D together, the circumferential alignment of the distal apex 3623 of the first stent 3626a and the proximal apex 3621 of the second stent 3626b can, for example, inhibit longitudinal compression (e.g., provide increased column force) when the aortic repair device 3600 is implanted in the aorta and subjected to forces from blood flow through the aorta. For example, the longitudinal compression (e.g., the difference between the length L1 of the body portion 3612 in the longitudinally elongated position shown in FIG. 36A and the length L2 of the body portion 3612 in the longitudinally compressed position shown in FIG. 36C) can be about 10% or less than 10%. In some aspects of the present technology, such inhibition of longitudinal compression can help maintain a seal between the body portion 3612 and the aorta when the aortic repair device 3600 is implanted therein. Additionally, the circumferential offset of the distal apex 3623 of the first stent 3626a and the proximal apex 3621 of the second stent 3626b can provide the body portion 3612 with greater flexibility.

[0116] For any of the aortic repair devices disclosed herein, the phase, amplitude, frequency, and / or spacing of the different stents (also referred to as stent components (e.g., stent rings, etc.)) of the aortic repair device can be selected to provide, at least in part, a desired axial stiffness and / or flexibility profile. Additionally or alternatively, the phase, amplitude, and / or frequency of individual stents can vary along their circumference to provide, at least in part, a desired axial stiffness and / or flexibility profile. FIG. 37A, for example, is a side perspective view of an aortic repair device 3700 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 3700 can include a base member 3710 having a body portion 3712, legs 3714 (partially obscured in FIG. 37A ) extending from the body portion 3712, and a septum (obscured in FIG. 37A ) extending completely or partially through the body portion 3712 and dividing the body portion 3712 into a primary lumen and a secondary lumen. The base member 3710 includes one or more stents 3726 coupled to a graft material 3728. More specifically, the stents 3726 along the body portion 3712 can include a first stent 3726a (e.g., a proximal stent), a second stent 3726b (e.g., a middle stent), and a third stent 3726c (e.g., a distal stent), each having a periodic V-pattern shape including alternating proximal and distal apexes 3721 and 3723. In the illustrated embodiment, the first stent 3726a and the second stent 3726b each have a different number of proximal and distal apexes 3721 and 3723 (e.g., different frequencies) and are arranged such that a subset (e.g., two) of the distal apexes 3723 of the first stent 3726a are circumferentially aligned with corresponding ones of the proximal apexes 3721 of the second stent 3726b (e.g., as described in detail above with reference to FIGS. 36A-36D).The second stent 3726b and the third stent 3726c are substantially identical and are arranged in phase (eg, as described in detail above with reference to Figures 34A and 34B).

[0117] 37B is a plan view of a first stent 3726a and a second stent 3726b in accordance with an embodiment of the present technology. In the illustrated embodiment, the first stent 3726a has a varying amplitude such that (i) the V-shaped portion of the first stent 3726a has a greater amplitude at a distal apex 3723 that is circumferentially aligned with a proximal apex 3721 of the second stent 3726b, and (ii) a gap G exists between the circumferentially offset distal apex 3723 of the first stent 3726a and the proximal apex 3721 of the second stent 3726b. 37A and 37B together, in some aspects of the present technology, this arrangement of the first and second stents 3726a-b (i) positions more of the flexible graft material 3728 between the stents 3726a-b (e.g., not supported by the stents 3726a-b) to increase flexibility therebetween where the distal apex 3723 of the first stent 3726a is circumferentially offset from the proximal apex 3721 of the second stent 3726b, and (ii) abuts the distal apex 3723 of the first stent 3726a against the circumferentially aligned proximal apex 3721 of the second stent 3726b to provide axial stiffness where the distal apex 3723 of the first stent 3726a is aligned with the proximal apex 3721 of the second stent 3726b.

[0118] 38 is a plan view of a first stent 3826a (e.g., a proximal stent) and a second stent 3826b (e.g., a distal stent) of an aortic repair device 3800 in accordance with an additional embodiment of the present technology. The first and second stents 3826a-b each have a periodic V-pattern shape including alternating proximal and distal apices 3821 and 3823. In the illustrated embodiment, the first stent 3726a has an irregular frequency (e.g., spacing between the proximal apexes 3821 and / or between the distal apexes 3823) and the second stent 3726b has a regular frequency such that one of the distal apexes 3823 of the first stent 3826a (identified as the aligned distal apex 3823i) is circumferentially aligned with a corresponding one of the proximal apexes 3821 of the second stent 3826b (identified as the aligned proximal apex 3821i). That is, a shift in the spacing between the proximal apexes 3821 and / or the distal apexes 3823 of the first stent 3826a (e.g., a shift in the width of its V-shaped portion) can align the aligned distal apex 3823i in close proximity to the aligned proximal apex 3821i. In some aspects of the present technology, the arrangement of aligned distal apices 3823i and aligned proximal apices 3821i can increase the axial (e.g., columnar) stiffness of the aortic repair device 3800. In other embodiments, the frequency of the first stent 3826a and / or second stent 3826b can be varied in other manners to align one or more of the distal apices 3823 of the first stent 3826a with one or more of the proximal apices 3821 of the second stent 3826b and provide a desired amount of axial stiffness.

[0119] 34A-38 illustrate various aortic repair devices having configurations of stents extending around the entire circumference / perimeter of the base member that constrain or permit longitudinal compression of the base member. In some embodiments, the axial stiffness and / or flexibility profile of the aortic repair device can be further selected based on the configuration of one or more secondary lumen stents (e.g., as described in detail above with reference to FIGS. 28A-33). For example, FIGS. 39A and 39B are side and side perspective views, respectively, of an aortic repair device 3900 in a first position, and FIG. 39C is a side perspective view of the aortic repair device 3900 of FIG. 39B in a second position in which the aortic repair device 3900 is longitudinally compressed, in accordance with an embodiment of the present technology. Similarly, Figures 40A and 40B are side and side oblique views, respectively, of aortic repair device 4000 in a first position, and Figure 40C is a side oblique view of aortic repair device 4000 in a second position in which aortic repair device 3900 is longitudinally compressed, in accordance with an embodiment of the present technology.

[0120] Aortic repair device 3900 and aortic repair device 4000 can include several features that are generally similar or identical. For example, referring together to Figures 39A-40C, both aortic repair device 3900 and aortic repair device 4000 include a base member 3910 having a body portion 3912, legs 3914 (partially obscured in Figures 39A-40C) extending from body portion 3912, and a septum (obscured in Figures 39A-40C) that extends completely or partially through body portion 3912 and divides body portion 3912 into a primary lumen and a secondary lumen. Base member 3910 includes one or more body stents 3926 (which may also be referred to as "aortic stents") coupled to graft material 3928. In the illustrated embodiment, the body stents 3926 are (i) generally identical (e.g., each having a periodic V-pattern shape with alternating proximal and distal apices and having the same amplitude and frequency), (ii) arranged in phase with one another, and (iii) separated from adjacent ones of the body stents 3926 by a gap G1 (FIGS. 39A and 40A). The base member 3910 further includes one or more secondary lumen stents 3929 (partially obscured in FIGS. 39B, 39C, 40B, and 40C) positioned within a secondary lumen defined in the body portion 3912. In the illustrated embodiment, the secondary lumen stents 3929 are (i) generally identical (e.g., each having a periodic V-pattern shape with alternating proximal and distal apices and having the same amplitude and frequency), (ii) arranged in phase with one another, and (iii) separated from adjacent ones of the secondary lumen stents 3929 by a gap G2 (FIGS. 39A and 40A). In some embodiments, the main body stent 3926 has generally the same amplitude as the secondary lumen stent 3929 but a lower frequency than the secondary lumen stent 3929.

[0121] 39A-39C together, in the illustrated embodiment, the secondary lumen stents 3929 substantially overlap (e.g., are axially aligned with) corresponding ones of the body stents 3926. Thus, the gaps G1 and G2 between the body stents 3926 and secondary lumen stents 3929, respectively, are partially or completely overlapped such that the graft material 3928 at the overlap is not supported by the body stent 3926 or the secondary lumen stent 3929 and may be easily folded and compressed to reduce or eliminate the gaps G1 and G2 between adjacent body stents 3926 and secondary lumen stents 3929. As shown in FIG. 39C, this arrangement of the body stents 3926 and secondary lumen stents 3929 can allow the body 3912 to compress longitudinally, for example, when the aortic repair device 3900 is implanted in the aorta and is subjected to forces from blood flow through the aorta. In some embodiments, the longitudinal compression (e.g., the difference between the length L1 of the body portion 3912 in the first position shown in FIG. 39B and the length L2 of the body portion 3912 in the longitudinally compressed second position shown in FIG. 39C) can be about 40%, less than about 40%, about 20%, less than about 20%, etc.

[0122] 40A-40C together, in the illustrated embodiment, the secondary lumen stent 3929 is shifted relative to the body stent 3926 such that the secondary lumen stent 3929 extends along (e.g., substantially overlaps with, is axially aligned with) corresponding ones of the gaps G1 between the body stents 3926. Similarly, the body stent 3926 extends along corresponding ones of the gaps G2 between the secondary lumen stents 3929. Thus, the graft material 3928 along the body portion 3912 has no, or few, axial positions where it is not supported by one of the body stents 3926 and / or the secondary lumen stents 3929. 40C , for example, when aortic repair device 3900 is implanted in the aorta and subjected to forces from blood flow through the aorta, this arrangement of body portion stent 3926 and secondary lumen stent 3929 can substantially inhibit longitudinal compression of body portion 3912. In some embodiments, the longitudinal compression (e.g., the difference between length L1 of body portion 3912 in the first position shown in FIG. 39B and length L2 of body portion 3912 in the longitudinally compressed second position shown in FIG. 39C) can be about 20%, less than about 20%, about 10%, less than about 10%, etc.

[0123] 39A-40C together, the secondary lumen stent 3929 can be combined with the body stent 3926 to provide a selected axial stiffness around the circumference of the implantable device 3900 / 4000. Because the secondary lumen stent 3929 is positioned within the secondary lumen of the body 3912, the stiffness provided by the secondary lumen stent 3929 only affects the portion (e.g., the side) of the body 3912 adjacent to the secondary lumen of the body 3912. Thus, in some embodiments, the secondary lumen of the body 3912 and the portion of the body 3912 adjacent to the secondary lumen stent 3929 therein can have a greater axial stiffness than the portion of the body 3912 adjacent to the primary lumen. In some aspects of the present technology, the relatively less stiff portion of the body 3912 adjacent to the primary lumen is configured to be positioned along the interior wall of the aortic arch, which has less curvature.

[0124] More specifically, for example, Figure 40D is a side view of an aortic repair device 3900 or aortic repair device 4000 implanted in the aorta in accordance with embodiments of the present technology. In the illustrated embodiment, the aortic repair device 3900 / 4000 is implanted in the ascending aorta such that the leg 3914 extends into a bifurcation artery (such as the brachiocephalic artery). Thus, the first side portion 4001 of the leg portion 3914 and the body portion 3912 (e.g., the side adjacent the secondary lumen extending through the body portion 3912) can be positioned against and / or adjacent to the first wall portion W1 of the aorta, and the second side portion 4002 (e.g., the side adjacent the primary lumen extending through the body portion 3912) can be positioned against and / or adjacent to the second wall portion W2 of the aorta, which has less curvature (e.g., lesser radius of curvature) and a shorter length than the first wall portion W1. In some embodiments, as described in detail above, the aortic repair device 3900 / 4000 can have greater axial stiffness (e.g., least compression) at the first side portion 4001 of the body portion 3912 adjacent the first wall portion W1 than at the second side portion 4002 of the body portion 3912 adjacent the second wall portion W2. For example, secondary lumen stent 3929 (39A-40C) can cooperate with body stent 3926 to resist longitudinal compression at first side 4001, but is absent from second side portion 4002 such that second side portion 4002 is relatively more flexible. Thus, in some aspects of the present technology, first side portion 4001 is in tension after deployment, while the relatively more flexible second side portion 4002 is able to axially compress and / or nest along second wall portion W2.

[0125] In other embodiments, the main body stents 3926 and / or secondary lumen stents 3929 can have other configurations (e.g., having different frequencies, amplitudes, shapes) and / or can be positioned differently relative to one another (e.g., out of phase with one another with little or no gap between them). With reference to FIG. 37A, for example, one or more secondary lumen stents 3729 (partially obscured) can (i) extend fully or partially between the first and second body stents 3726a and 3726b having varying frequencies to provide increased axial stiffness therebetween, and / or (ii) extend fully or partially between the second and third body stents 3726b and 3726c to provide increased axial stiffness therebetween.

[0126] In any of the embodiments described herein, the graft material of the aortic repair device can be sewn or otherwise attached to the stent of the aortic repair device. In other embodiments, the stent can be inserted through a corresponding channel or pocket in the graft material to secure the stent to the graft material. For example, FIGS. 41A and 41B are side views of a spanning member 4150 in accordance with an embodiment of the present technology. FIG. 41C is an enlarged view of a portion of the spanning member 4150 shown in FIG. 41B in accordance with an embodiment of the present technology. Referring together to FIGS. 41A-C, the spanning member 4150 includes a graft material 4158 having pockets or channels 4159 configured (e.g., shaped and sized) to receive corresponding ones of a plurality of stents 4156 through small access openings or ports 4157. The stents 4156 are removed from the channels 4159 in FIG. 41A and inserted into the channels 4159 in FIG. 41B and FIG. 41C. The graft material 4158 can be formed by weaving or another suitable method that allows for the creation of channels 4159 in its wall. The stent 4156 can then be inserted into the channel 4159 to have a desired shape. For example, the channel 4159 can have a zigzag pattern, a Z pattern, a V pattern, a straight pattern, a sinusoidal spiral pattern, etc., such that the stent 4156 conforms to the shape of the channel 4159. The stent 4156 can be a wire that is inserted (e.g., pulled and / or pushed via a tether) through the access opening 4157 into and through the channel 4159, and can have atraumatic (e.g., ball) ends and / or can be crimped after insertion into the channel 4159. Any of the components of the aortic repair devices described herein (e.g., spanning members, base members, etc.) can be formed in such a manner.

[0127] In some embodiments, graft material can be omitted or removed from the distal and / or proximal end portions of any of the components (e.g., spanning members, base members, etc.) of the aortic repair devices described herein. For example, FIGS. 41D-41F are close-up views of proximal or distal end portions of various aortic repair device 4100a-4100c components (e.g., any of the base members and / or spanning members described herein), respectively, in accordance with embodiments of the present technology. Referring together to FIGS. 41D-41F, aortic repair devices 4100a-c each include a stent 4126 having an apex 4121 and graft material 4128 secured to stent 4126 via stitches 4127. Apex 4121 can be an apex located at the most distal and / or most proximal end portion of the component.

[0128] 41D, the graft material 4128 can extend only partially along the stent 4126 such that the apexes 4121 are exposed from the graft material 4128. In the illustrated embodiment, the edges 4129a of the graft material 4128 are linear. This configuration defines apertures between the individual apexes 4121 and the edges 4129a of the graft material 4128, leaving a portion of the space between adjacent apexes 4121 open, both of which allow blood to flow therethrough.

[0129] 41E, the graft material 4128 may extend only partially along the stent 4126 and follow the curvature of the stent 4126 between the apexes 4121, leaving the apexes 4121 and the spaces between them exposed from the graft material 4128. Thus, in the illustrated embodiment, the graft material 4128 defines edges 4129b that generally follow (e.g., follow) the struts of the stent 4126 between the apexes 4121, and may form inlets 4122b (also referred to as openings, recesses, or serrations) at the edges 4129b of the graft material 4128. The inlets 4122b may be formed along the edges 4129b by removing (e.g., via trimming) all or a portion of the graft material 4128 between the apexes 4121 before and / or after attachment to the stent 4126.

[0130] 41F, the graft material 4128 can extend completely to the apexes 4121 of the stent 4126, and the graft material 4128 can include first openings 4122c (e.g., serrations, inlets) between the apexes 4121 and can include second openings 4124 in (e.g., below) each apex 4121. The first and second openings 4122c, 4124 can be formed by removing some of the graft material 4128 from between and / or from within the apexes, respectively. Thus, in the illustrated embodiment, the graft material 4128 defines edges 4129c that generally follow (e.g., follow) the curvature of the struts of the stent 4126 along the circumference of the stent 4126, and also provides openings between the struts.

[0131] As explained above, the arrangement of graft material 4128 and stent 4126 shown in FIGS. 41D-41F provides openings, inlets, and / or exposed stent regions at one or both ends of the spanning and / or base members. This allows lateral flow through the end regions of the spanning / base members, which can aid in placement because it increases the viable landing zone for the device and reduces the precision required to align the end regions with the target site. For example, the spanning / base members can overshoot the target site, allowing the end regions to be exposed in the vessel and / or allowing the end regions to overlie a branch lumen (e.g., a vessel or other stent component) partially or completely without disrupting blood flow. This can be particularly useful when placing in curved vessels (e.g., the aortic arch), where the curvature can make alignment of the stent more difficult than in substantially linear vessels.

[0132] In some embodiments described herein, the legs and / or other portions of the aortic repair device can be angled or otherwise oriented to match the anatomy of the aorta. For example, FIG. 42A is an anterior view of the aorta and surrounding anatomy into which an aortic repair device may be implanted according to embodiments of the present technology. As shown in FIG. 42A, the aorta (e.g., the ascending aorta, the aortic arch, and / or the upper portion of the descending thoracic aorta) can generally lie in plane P. The left common carotid artery and the left subclavian artery can extend along axes A1 and A2, respectively, that are angled (e.g., not parallel to plane P) with respect to plane P, and the brachiocephalic artery can extend along axis A3, which is more angled with respect to plane P than axes A1 and A2. That is, the brachiocephalic artery can be positioned further out of plane P of the aorta than the left common carotid artery and the left subclavian artery. Thus, an aortic repair device according to embodiments of the present technology can have legs arranged to accommodate angled take-off into the brachiocephalic trunk, left common carotid artery, and / or left subclavian artery.

[0133] More specifically, for example, Figures 42B-42D are side views of aortic repair devices 4200b-4200d, respectively, in accordance with an embodiment of the present technology. Referring together to Figures 42B-42D, aortic repair devices 4200b-d can each include a base member 4210 having a body portion 4212 configured for implantation within the aorta, legs 4214, and a septum (obscured in Figures 42B-42D) extending from body portion 4212 and configured for implantation within a bifurcation vessel (e.g., the brachiocephalic artery, the left common carotid artery, and / or the left subclavian artery), and the septum extending fully or partially through body portion 4212 and dividing body portion 4212 into a primary lumen and a secondary lumen.

[0134] With reference to FIG. 42B, the legs 4214 can extend generally parallel to the longitudinal axis L of the body portion 4212. With reference to FIGS. 42C and 42D together, the legs 4214 can be angled at an angle B relative to the longitudinal axis L of the body portion 4212. With reference to FIGS. 42A, 42C, and 42D together, the angle B can be selected to correspond to or substantially match the angle at which one of the brachiocephalic trunk, left common carotid artery, and / or left subclavian artery is angled relative to the plane P. Thus, in some aspects of the present technology, the legs 4214 of the aortic repair devices 4200c-d can be offset from the longitudinal axis L of the body portion 4212 to better mate with the angled anatomy of the bifurcation vessel relative to the aorta in which the body portion 4212 is implanted. This can reduce the degree of bending of the legs 4214 relative to the body portion 4212 and / or can reduce kinking of the legs 4214 when the aortic repair devices 4200c-d are implanted into an anatomical structure with offset branch arteries. With reference to FIG. 42C, in some embodiments, the proximal openings 4215 of the legs 4214 are also angled relative to the longitudinal axis L of the body portion 4212. With reference to FIG. 42D, in some embodiments, the proximal openings 4215 are beveled, e.g., such that the proximal openings 4215 extend perpendicular to the longitudinal axis L to maintain a cross-sectional flow area of ​​the proximal openings 4215.

[0135] FIG. 86 is a side view of an aortic repair device 8600 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 8600 includes a base member 8610 having a body portion 8612 configured for implantation in the aorta and legs 8614 extending from the body portion 8612 and configured for implantation in a bifurcation vessel (e.g., the brachiocephalic artery, the left common carotid artery, and / or the left subclavian artery). In FIG. 86, the aortic repair device 8600 is shown partially exploded, with the legs 8614 separated from the primary lumen of the body portion 8612 for clarity. When the aortic repair device 8600 is assembled, the septum 8618 extends completely or partially through the body portion 8612, dividing the body portion 8612 into a primary lumen and a secondary lumen, the primary lumen providing fluid flow through the portion of the body portion 8612 that is not captured by the leg portion 8614, and the secondary lumen providing fluid flow through the leg portion 8614.

[0136] In the illustrated embodiment, the legs 8614 have a central axis C that extends perpendicular to their trailing (e.g., distal) opening 8622, and the body portion 8612 has a central axis L that extends perpendicular to its leading (e.g., proximal) opening 8620 and trailing (e.g., distal) primary lumen opening 8621. In some embodiments, the central axis C of the legs 8614 is non-parallel (e.g., angled, offset) to the central axis L of the body portion 8612. This offset in the central axes of the body portion 8612 and the legs 8614 can cause the legs 8614 to curve, curl, or spiral (e.g., partially spiral) around the arch of the arterial lumen when the aortic repair device 8600 is implanted in the aorta. The angled leg 8614 allows the aortic repair device 8600 to beneficially absorb force and / or flow proximate a leading portion of the leg 8614 (e.g., a D-shaped channel in the leg 8614 formed by one or more D-shaped stents), which is closer to the lesser curvature of the aorta, and then transitions to a trailing portion of the leg 8614 as it curls and exits the aorta. In some embodiments, the aortic repair device 8600 can include one or more radiopaque markers 8619, for example, positioned at a proximal end of the body portion 8612 (e.g., on the outer curvature of the body portion 8612).

[0137] III. SELECTED EMBODIMENTS OF AORTA REPAIR DEVICES COMPRISING MULTIPLE LEGS 43A and 43B are side and side perspective views, respectively, of an aortic repair device 4300 in accordance with an embodiment of the present technology. Aortic repair device 4300 can include certain features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of any of the aortic repair devices described in detail above with reference to FIGS. 3A-42D and can operate in a generally similar or identical manner as the aortic repair devices of FIGS. 3A-42D. For example, in the illustrated embodiment, aortic repair device 4300 includes a base member 4310 configured to be implanted within the diseased aorta and includes a stent graft including, for example, a graft material 4328 attached to a plurality of stents 4326.

[0138] In the illustrated embodiment, the base member 4310 includes (i) a tubular body portion 4312, (ii) a tubular primary leg 4340 extending distally from the body portion 4312, and (iii) a tubular secondary leg 4314 extending distally from the body portion 4312. More specifically, the body portion 4312 includes a proximal end portion 4311 that defines a proximal end of the base member 4310, and a distal end portion 4313. The primary leg 4340 includes a proximal end portion 4345 that is coupled to the distal end portion 4313 of the body portion 4312, and a distal end portion 4347. The secondary leg 4314 includes a proximal end portion 4315 that is coupled to the distal end portion 4313 of the body portion 4312, and a distal end portion 4327 that defines a distal end of the base member 4310. In the illustrated embodiment, the body portion 4312 has a first length L1, the primary leg 4340 has a second length L2 that is less than the first length L1, and the secondary leg 4324 has a third length L3 that is greater than the second length L2. In other embodiments, the first to third lengths L1-L3 can be different. For example, the third length L3 can be less than the length L1 and / or less than the length L2. In some embodiments, the first length L1 can be between about 20-80 millimeters, the second length L2 can be between about 20-40 millimeters, and the third length L3 can be between about 30-100 millimeters.

[0139] The base member 4310 can be generally hollow and can define one or more lumens therethrough. Thus, in the illustrated embodiment, the base member 4310 includes (i) a proximal opening 4320 (e.g., first opening, inlet) at a proximal end portion 4311 of the body portion 4310 and having a first diameter D1 (FIG. 43A), (ii) a distal primary leg opening 4321 (e.g., second opening, distal body portion outlet) at a distal end portion 4347 of the primary leg 4340 and having a second diameter D2 (FIG. 43A), and (iii) a distal secondary leg opening 4322 (e.g., third opening, distal leg outlet) at a distal end portion 4317 of the secondary leg 4314 and having a third diameter D3 (FIG. 43A). The first diameter D1 is larger than the second and third diameters D2, D3 and can be sized to generally match or be larger than (e.g., oversized relative to) the diameter of the patient's aorta (e.g., between about 20-60 mm, between about 26-54 mm, about 40 mm). The third diameter D3 can be sized to generally match or be larger than (e.g., between about 10-30 mm, about 18 mm) a bifurcation vessel of the patient's aorta, such as the brachiocephalic artery. In some embodiments, the second diameter D2 can be larger than the third diameter D3 (e.g., between about 20-40 mm, about 28 mm).

[0140] FIG 43C is a distal facing perspective end view of aortic repair device 4300 of FIGS. 43A and 43B in accordance with an embodiment of the present technology. With reference to FIG 43C, body portion 4312 and primary leg 4340 together define a primary lumen 4323 through base member 4310, and body portion 4312 and secondary leg 4314 together define a secondary lumen 4325 through base member 4310. With reference to FIGS. 43A-C together, primary lumen 4323 can extend from proximal opening 4320 and primary leg opening 4321 and define a flow path between proximal opening 4320 and primary leg opening 4321. Similarly, the secondary lumen 4325 can extend from the proximal opening 4320 and the secondary leg opening 4322 and define a flow path between the proximal opening 4320 and the secondary leg opening 4322. As shown in FIG. 43C, the primary lumen 4323 and the secondary lumen 4325 can have generally circular cross-sectional shapes in the body portion 4312 and in the primary legs 4340 and secondary legs 4314, respectively.

[0141] FIG. 43D is a side view of an aortic repair device 4300 implanted in the aorta, according to an embodiment of the present technology. In some embodiments, the aorta may include an aneurysm, dissection, and / or other diseased portion, as described in detail above with reference to FIGS. 1A-2B. In the illustrated embodiment, the body portion 4312 is implanted in the proximal aorta (e.g., the ascending aorta and / or aortic arch) with the proximal end portion 4311 positioned adjacent the aortic valve, the secondary leg portion 4314 extends from the body portion 4312 to the brachiocephalic artery, and the distal end portion 4317 is positioned in the brachiocephalic artery. Referring together to FIGS. 43A-43D, the stent 4326 can expand the graft material 4328 into contact with the inner wall of the aorta and / or brachiocephalic artery to provide a seal between the vessel and the base member 4310. More specifically, body portion 4312 can sealingly contact the inner wall of the proximal aorta such that all or substantially all blood flow through the aorta enters proximal opening 4320 and flows through either primary lumen 4323 or secondary lumen 4325. As shown in FIG. 43D , base member 4310 can direct blood flow (i) from primary leg opening 4321 through primary lumen 4323 into the aorta to perfuse the aorta, and can also direct blood flow (ii) from secondary leg opening 4322 through secondary lumen 4325 into the brachiocephalic artery to perfuse the brachiocephalic artery.

[0142] The base member 4310 can be delivered to the aorta in a collapsed configuration within a catheter system (not shown) that can access the aorta via any suitable intravascular route (e.g., aortic approach, transfemoral approach, transcarotid approach, left common carotid artery (LCCA) approach, left subclavian artery (LSA) approach, etc.).

[0143] In some aspects of the present technology, the base member 4310 can be positioned against / adjacent to a diseased portion of the aorta (e.g., origin of dissection and / or aneurysm, etc.) and can block blood flow into the diseased portion by diverting blood flow through the base member 4310. In additional aspects of the present technology, the outer surface of the body portion 4310 has a tubular shape configured to engage and seal with the inner wall of the aorta, but the base member 4310 may not seal against the aorta along the length of the primary leg 4340 and the secondary leg 4314. Thus, the base member 4310 can provide a relatively shorter sealing area compared to the base member 310, e.g., described in detail above with reference to FIGS. 3A-3D. However, the primary lumen 4323 can have a generally circular cross-sectional shape in the primary leg 4340. This can facilitate coupling of other implantable devices (e.g., spanning members, etc.) to the base member 4310.

[0144] 44A-44C, for example, are a side view, a side perspective view, and a distally facing perspective end view, respectively, of a spanning member 4450, in accordance with an embodiment of the present technology. Referring together to FIGs. 44A-44C, the spanning member 4450 can include certain features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of any of the spanning members described in detail above with reference to FIGs. 3A-38B, and can operate in a generally similar or identical manner as the spanning members of FIGs. 3A-38B.

[0145] For example, in the illustrated embodiment, the spanning member 4450 includes a body portion 4452 having a tubular shape defining a spanning lumen 4457 and extending between a proximal end portion 4451 and a distal end portion 4453. Thus, in the illustrated embodiment, the body portion 4452 includes a proximal opening 4454 and a distal opening 4455. The spanning member 4450 can include an expandable stent graft including one or more struts or stents 4456 and a graft material 4458 coupled to the stent 4456.

[0146] In the illustrated embodiment, the spanning member 4450 further includes an anchor 4460 at and / or coupled to a proximal end portion 4451 of the body portion 4452. The anchor 4460 can be a bare stent or other expandable element and can have a first diameter D1 (FIG. 44B) that is greater than a second diameter D2 (FIG. 44B) of the body portion 4452 when the spanning member 4450 is expanded and unconstrained (e.g., outside the aorta). In the illustrated embodiment, the anchor 4460 is a bare stent having a generally circular cross-sectional shape and a V-pattern. In some embodiments, the anchor 4460 can be laterally offset relative to the body portion 4452, e.g., such that a longitudinal axis concentric with the anchor 4460 is offset from a longitudinal axis concentric with the body portion 4452.

[0147] 44D and 44E are side perspective and side views, respectively, of an aortic repair device 4400 including a spanning member 4450 coupled (e.g., docked) to the base member 4310 of FIGS. 43A-43D in accordance with an embodiment of the present technology. Referring together to FIGS. 44D and 44E, an anchor 4460 and a proximal end portion 4451 of a body portion 4452 are at least partially positioned within the base member 4310. More specifically, (i) the anchor 4460 is expanded into contact with an inner surface of the body portion 4312 and is capable of anchoring and fixing the body portion 4452 of the spanning member 4450 to the base member 4310, and (ii) the proximal end portion 4451 of the body portion 4452 is expanded into contact with an inner surface of the primary leg 4344 and sealingly engaging therewith. In the illustrated embodiment, the anchors 4460 are offset relative to the body portion 4452 of the spanning member 4450 such that the anchors 4460 engage substantially the entire circumference of the body portion 4312 .

[0148] 43A-44E together, the aortic repair device 4400 can define a continuous blood flow path from the proximal opening 4320 of the base member 4310, through the primary lumen 4325, through the spanning lumen 4457, to the distal opening 4455. In some aspects of the present technology, increasing the second length L2 (FIG. 43A) of the primary leg 4344 can increase the area available for sealing between the spanning member 4450 and the base member 4310, thereby increasing the potential robustness of the seal therebetween. However, increasing the second length L2 requires decreasing the length L1 of the body portion 4312 (thereby decreasing the area available for sealing between the body portion 4312 and the aorta) or increasing the combined length of the body portion 4312 and the primary leg 4344. Thus, in some aspects of the present technology, the second length L2 is (i) simply selected to be long enough to ensure a robust seal between the spanning member 4350 and the primary leg 4344, and (ii) selected to correspondingly maximize the first length L1 and ensure a robust seal between the body portion 4312 and the aorta. In some embodiments, the second length L2 is about 1 centimeter.

[0149] For example, as described in detail above with reference to FIG. 4, the spanning member 4450 can divert blood flow past a diseased portion of the aorta (e.g., an aneurysm in the aortic arch ( FIG. 43D ) etc.) when the aortic repair device 4400 is implanted in a patient. In some embodiments, the spanning member 4450 can be delivered to the aorta in a collapsed configuration within a catheter system (not shown) in the same or a separate procedure as the base member 4310. For example, in many cases, a patient may initially require treatment only in the ascending aorta and / or aortic arch to treat an initial dissection or aneurysm, but at a later point in time (e.g., months or years later), may require additional treatment of the aortic arch and / or descending thoracic aorta as the diseased condition progresses. Thus, the base member 4310 can be implanted during an initial procedure and the spanning member 4450 can be implanted during a later procedure and modularly coupled to the base member 4310 to provide further treatment of the aortic arch and / or descending thoracic aorta (e.g., by bypassing blood flow past the aneurysm shown in FIG. 43D).

[0150] 45A is an enlarged side view of a spanning member 4550, in accordance with an embodiment of the present technology. The spanning member 4550 can include certain features that are at least generally similar (or identical) in structure and function to corresponding features of the spanning member 4450, described in detail above with reference to FIGS. 44A-44E, and can operate in a generally similar or identical manner as the spanning member 4450. For example, the spanning member 4550 includes a tubular body portion 4552 (e.g., a stent graft) that defines a lumen and has a proximal end portion 4551. In the illustrated embodiment, the spanning member 4550 further includes a plurality of anchoring or fixation elements 4560 at and / or coupled to the proximal end portion 4551. The fixation elements 4560 can be hooks, wires, loops, and / or other elements.

[0151] 45B is a side view of an aortic repair device 4500 including a spanning member 4550 coupled (e.g., docked) to the base member 4310 of FIGS. 43A-43D in accordance with an embodiment of the present technology. In the illustrated embodiment, a fixation element 4560 secures and seals a proximal end portion 4551 of the body portion 4552 to the inner surface of the primary leg 4340 of the base member 4310. In other embodiments, additional fixation elements can alternatively or additionally be positioned on the inner surface of the primary leg 4340. For example, such fixation elements can include a portion of one or more stents used to form the base member 4310 that protrude inwardly into the lumen of the primary leg 4340.

[0152] Figure 45C is a proximal-facing perspective view of the primary leg 4340 of the base member 4310 of Figure 45B in accordance with an embodiment of the present technology. Figure 45D is an enlarged side perspective view of the proximal end portion 4551 of the spanning member 4550 of Figure 45A in accordance with an embodiment of the present technology. Figure 45E is a proximal-facing perspective view of the spanning member 4550 coupled to the primary leg 4340 of the base member 4310 in accordance with an embodiment of the present technology. 45C, some or all of the stents 4326 in the primary leg 4340 can include (i) a first portion 4529 that is secured to the graft material 4328 (e.g., via sutures) and that apposes the graft material 4328, and (ii) a second portion 4527 (e.g., an exposed portion, a non-sewn portion) that is not secured to the graft material 4328 and that extends radially inward from (e.g., tilted or lifted away from) the inner surface of the graft material 4328. As shown in FIG. 45D, the spanning member 4550 can include one or more stents 4556 and graft material 4558. Some or all of the stents 4556 may similarly include (i) a first portion 4559 that is secured to the graft material 4558 (e.g., via sutures) and apposes the graft material 4558, and (ii) a second portion 4557 (e.g., an exposed portion, a non-sewn portion) that is not secured to the graft material 4558 and extends radially outward from the outer surface of the graft material 4558 (e.g., tilted or lifted away from the outer surface of the graft material 4558).

[0153] As shown in FIG. 45E, when the spanning member 4550 is connected to the primary leg 4340, the second portion 4527 of the primary leg 4340 can face, interlock, and / or engage with the second portion 4557 of the spanning member 4550 to inhibit migration of the spanning member 4550 relative to the base member 4310. In some embodiments, the connection of the spanning member 4550 to the primary leg 4340 of the base member 4310 can be modulated by adjusting (i) the extent to which the second portion 4527 of the stent 4326 of the base member 4310 projects inward toward the spanning member 4550, (ii) the extent to which the second portion 4557 of the stent 4556 of the spanning member 4550 projects outward toward the primary leg 4340, (iii) the frequency / periodicity of the second portion 4527 of the stent 4326 of the primary leg 4340, and / or (iv) the frequency / periodicity of the second portion 4557 of the stent 4556 of the spanning member 4550, such that some areas of the free second portions 4527, 4557 are more likely to interface when the spanning member 4550 is connected to the primary leg 4340.

[0154] 46 is a side perspective view of a base member 4610 of an aortic repair device 4600 in accordance with an embodiment of the present technology. The base member 4610 can include certain features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of the base member 3910 described in detail above with reference to FIGS. 39A-39D and can operate in a generally similar or identical manner as the base member 3910. For example, the base member 4610 includes a proximal body portion 4612, a primary leg 4640 extending distally from the body portion 4612, and a secondary leg 4614 extending distally from the body portion 4612. However, in the illustrated embodiment, the primary leg 4660 extends at an angle A relative to the body portion 4612 and the secondary leg 4614, for example, between about 30° and 60° (e.g., about 45°). In some aspects of the present technology, the angled primary leg 4640 can be angled toward / along the ascending aorta or another portion of the aorta, thereby making the primary leg 4640 more amenable to connection of a spanning member or other implant. More specifically, the angled primary leg 4640 can be oriented toward / along the natural inner curvature of the ascending aorta.

[0155] IV. SELECTED EMBODIMENTS OF AORTIC REPAIR DEVICES HAVING REDUCED DELIVERY PROFILE In some aspects of the present technology, the graft material is a major component of the aortic repair device that contributes to the volume of the device and its ability to be packaged into a catheter. Thus, reducing the amount of graft material in the overall aortic repair device and / or efficiently distributing the graft material over the separately delivered components of the aortic repair device (e.g., base member, spanning member, etc.) can reduce the delivery profile of the aortic repair device, potentially allowing it to be loaded into and delivered through smaller catheters and / or delivered along narrower intravascular delivery paths. Figures 47A-56C illustrate different examples of aortic repair devices having reduced delivery profiles. The aortic repair devices described in detail with reference to Figures 47A-56C may include certain features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of each other and / or of any of the aortic repair devices described in detail above with reference to Figures 3A-46 and may operate in a generally similar or identical manner to each other and / or to the aortic repair devices of Figures 3A-46.

[0156] 47A and 47B are a distal facing perspective view and a distal facing perspective end view, respectively, of an aortic repair device 4700 in accordance with an embodiment of the present technology. Referring together to FIGS. 47A and 47B, aortic repair device 4700 includes a base member 4710 having a body portion 4712 defining a primary lumen 4723. Aortic repair device 4700 further includes a separate leg member 4714 coupled to body portion 4712 and defining a secondary lumen 4725. Leg member 4714 can be a stent graft having a similar structure as base member 4710.

[0157] 47C and 47D are side and proximal facing perspective end views, respectively, of the base member 4710 of FIGS. 47A and 47B in accordance with an embodiment of the present technology. Referring together to FIGS. 47A-47D, the base member 4710 includes a graft material 4728 attached to a plurality of stents 4726. In the illustrated embodiment, exposed portions 4727 (e.g., V-segments) of one or more of the stents 4726 are not attached to the graft material 4728, and the exposed portions 4727 are at least partially aligned to define a channel 4729. A proximal portion 4715 of the leg member 4714 is inserted into the channel 4729 and sealingly engages an inner surface of the body portion 4712. In some embodiments, the exposed portion 4727 of the stent 4726 exerts a radial force against the leg member 4714 that maintains the leg member 4714 in sealing engagement with the inner surface of the body portion 4712. That is, the exposed portion 4727 of the stent 4726 can act as an internal attachment mechanism for the leg member 4714. Thus, in the illustrated embodiment, the leg member 4714 is a separate component from the base member 4710, which does not include a septum therein.

[0158] 47E-G are cross-sectional views of a base member 4710 taken along one of the stents 4726, according to an embodiment of the present technology. As shown in FIG. 47E, in some embodiments, the exposed portion 4727 of the stent 4726 is in full contact / apposition with the inner surface of the graft material 4728 before the leg members 4714 (FIGS. 47A and 47B) are inserted through the channels 4729 between the exposed portion 4727 and the graft material 4728. As shown in FIG. 47F, in some embodiments, the exposed portion 4727 extends radially inward from the inner surface of the graft material 4728 (e.g., is "tilted" away from the inner surface of the graft material 4728) before the leg members 4714 (FIGS. 47A and 47B) are inserted through the channels 4729 between the exposed portion 4727 and the graft material 4728. As shown in FIG. 47G, in some embodiments, the exposed portion 4727 includes a contact portion 4797 juxtaposed to the graft material 4728 and an apex portion 4798 that extends radially inward from the inner surface of the graft material 4728 (e.g., lifted away from the inner surface of the graft material 4728) before the leg member 4714 (FIGS. 47A and 47B) is inserted through the channel 4729 between the exposed portion 4727 and the graft material 4728.

[0159] In some embodiments, the leg member 4714 can be implanted during the same or a separate procedure as the base member 4710. For example, the base member 4710 can be implanted during an initial procedure (e.g., an index procedure) with the stent 4726 driving the graft material 4728 to seal against the aorta and to divert flow past the diseased portion of the aorta. Then, if the diseased condition progresses, the leg member 4714 can be implanted to divert flow through the advanced diseased condition, either alone or in combination with one or more implantable devices. In the embodiment shown in FIG. 47F and FIG. 47G, the exposed portion 4727 of the stent 4726 can provide a pathway for cannulation of a guidewire used to implant the leg member 4714, as the exposed portion 4727 does not fully appose to the graft material 4728.

[0160] 48A-48D are isometric side, side perspective, enlarged side perspective, and distal facing perspective end views, respectively, of an aortic repair device 4800 in accordance with an embodiment of the present technology. FIGS. 48E-48H are cross-sectional views of an aortic repair device 4800 as shown in FIG. 48A in accordance with an embodiment of the present technology. Referring together to FIGS. 48A-48D, in the depicted embodiment, the aortic repair device 4800 includes a base member 4810 configured to be implanted within a diseased aorta. The base member 4810 can include a body portion 4812 and legs 4814 extending distally from the body portion 4812. The body portion 4812 can define a proximal end portion 4811 of the base member 4810, and the legs 4814 can define a distal end portion 4817 of the base member 4810. The base member 4810 can include a stent graft including graft material 4828 attached to a plurality of stents 4826 (including individually identified proximal and distal stents 4826a and 4826b). In the illustrated embodiment, the proximal stent 4826a has a generally circular or ring-like shape and the graft material 4828 extends only around a portion of the proximal stent 4826a, dividing the body portion 4812 into (i) a primary lumen 4823 that is not surrounded by the graft material 4828 and (ii) a secondary lumen 4825 that is surrounded by the graft material 4828. In some embodiments, the graft material 4828 includes a separate or integral septum 4818 that divides the body portion 4812 into the primary and secondary lumens 4823, 4825. The septum 4818 can extend completely or partially through the body portion 4812 and can be centrally located or offset within the body portion 4812 such that the primary and secondary lumens 4823, 4825 have the same or different sizes. Thus, the primary and secondary lumens 4823, 4825 can each have a generally D-shaped cross-sectional shape within the body portion 4812, as shown in Figures 48E and 48F.

[0161] The secondary lumen 4825 can extend to and through the legs 4814. In the illustrated embodiment, the distal stent 4826b can also have a generally circular or ring-like shape, and the graft material 4828 can extend entirely around the distal stent 4826b to partially define the secondary lumen 4825. The secondary lumen 4825 can have a generally circular cross-sectional shape in the legs 4814, as shown in FIG. 48H. In some embodiments, the base member 4810 includes a transition region 4861 ( FIG. 48A ) between the legs 4814 and the body portion 4812, and the secondary lumen 4825 extends through the transition region 4861, where it has a cross-sectional shape as shown in FIG. 48B , which transitions between a D-shaped cross-sectional shape in the body portion 4812 and a circular cross-sectional shape in the legs 4814.

[0162] The base member 4810 and corresponding spanning member can be delivered to the aorta in a collapsed configuration in the same or separate catheter systems. The catheter systems can access the aorta via any suitable intravascular route (e.g., aortic approach, transfemoral approach, transcarotid approach, left common carotid artery (LCCA) approach, left subclavian artery (LSA) approach, etc.). In some aspects of the present technology, omitting graft material around the primary lumen 4823 can reduce the overall delivery profile of the base member 4810, potentially allowing the base member 4810 to be loaded into and delivered through smaller catheters and / or delivered along narrower intravascular delivery routes.

[0163] The primary lumen 4823 is configured (e.g., shaped, sized, and positioned) to receive the spanning member therein and / or thereabout when the base member 4810 is implanted in the aorta. FIG. 49 is an isometric side view of a spanning member 4950 configured to be coupled to a base member 4810, for example, in accordance with an embodiment of the present technology. In the illustrated embodiment, the spanning member 4950 is a stent graft including graft material 4958 that defines a spanning lumen 4957 and extends between a proximal end portion 4951 and a distal end portion 4953.

[0164] 48A-49 together, spanning member 4950 can have a D-shaped cross-sectional shape that is sized to match the D-shaped cross-sectional shape of primary lumen 4823. Spanning member 4950 can be secured to proximal stent 4826a around and / or within primary lumen 4823 such that graft material 4958 of spanning member 4950 engages and seals with (i) graft material 4828 around secondary lumen 4825 (e.g., septum 4818) and (ii) the wall of the aorta. In this manner, the main body portion 4812 (e.g., graft material 4828 around the secondary lumen 4825) and the spanning member 4950 coupled in / around the primary lumen 4823 can together provide a complete circumferential seal about the wall of the aorta and can be positioned against / adjacent to a diseased portion of the aorta (e.g., the origin of a dissection and / or an aneurysm, etc.) and can block blood flow into the diseased portion by diverting the blood flow through the base member 4810 and the spanning member 4950 and past the diseased portion.

[0165] 50 is a side view of an aortic repair device 4600 including a pair of base members 4810 (individually identified as proximal base member 4810a and distal base member 4810b) of FIGS. 48A-48H and spanning member 4950 of FIG. 49 implanted within the aorta in accordance with an embodiment of the present technology. Various components of proximal base member 4810a are referenced with an "a" on their trailing side (e.g., body portion 4812a) and various components of distal base member 4810b are referenced with a "b" on their trailing side (e.g., body portion 4812b). In some embodiments, the aorta may include an aneurysm, dissection, and / or other diseased portion, as described in detail above with reference to FIGS. 1A-2B.

[0166] In the illustrated embodiment, the body portion 4812a of the proximal base member 4810a is implanted in the proximal aorta (e.g., the ascending aorta and / or the aortic arch) with (i) the proximal end portion 4811a positioned proximate the aortic valve and (ii) the secondary leg 4814a extending from the body portion 4812a to the brachiocephalic artery (with the distal end portion 4817a positioned in the brachiocephalic artery). The body portion 4812b of the distal base member 4810b is implanted in the descending thoracic aorta (and / or partially in the aortic arch) with (i) the end portion 4811b positioned most distally in the aorta and (ii) the secondary leg 4814b extending from the body portion 4812b to the left common carotid artery (with the end portion 4817b positioned in the left common carotid artery). Thus, the distal base member 4810b can be oriented opposite the proximal base member 4810a. The spanning member 4950 can extend between the base members 4810, with a proximal end portion 4951 coupled to the body portion 4812a of the proximal base member 4810a and a distal end portion 4953 coupled to the body portion 4812b of the distal base member 4810b.

[0167] The body portion 4812a of the proximal base member 4810a and the proximal end portion 4951 of the spanning member 4950 together can engage and seal against a proximal portion of the aorta (e.g., a diseased portion of the ascending aorta including a fissure). The body portion 4812b of the distal base member 4810b and the distal end portion 4953 of the spanning member 4950 together can engage and seal against a distal portion of the aorta (e.g., a portion of the descending thoracic aorta). Thus, the proximal base member 4810a can direct blood flow from the aortic valve (i) through the secondary leg 4814a into the brachiocephalic artery to perfuse the brachiocephalic artery, and can direct blood flow from the aortic valve (ii) through the spanning member 4950 and past the distal base member 4810b into the aorta to perfuse the aorta. In the illustrated embodiment, the spanning member 4950 routes blood flow past the diseased portion of the aortic arch (e.g., the aneurysm shown). In some embodiments, blood can flow retrogradely from the aorta through the secondary leg 4814b to perfuse the left common carotid artery. In some embodiments, a bypass can be surgically placed between the brachiocephalic trunk and the left subclavian artery and / or between the left common carotid artery and the left subclavian artery to perfuse the left subclavian artery.

[0168] 51A-51C are side, side perspective, and perspective end views, respectively, of an aortic repair device 5100 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 5100 includes a base member 5110 including a stent graft including septa 5118 attached to a plurality of stents 5126. In the illustrated embodiment, the stents 5126 are generally bare (e.g., not covered with graft material), each having a generally circular or ring-like shape with a V-pattern, and are at least partially coaxially aligned. The septa 5118 interconnect the stents 5126 and divide the base member 5110 into a primary lumen 5123 and a secondary lumen 5125. In some embodiments, the septa 5118 extend along a diameter of each of the stents 5126 such that the primary and secondary lumens 5123, 5125 have the same size and D-shaped cross-sectional shape. In other embodiments, one or more of the stents 5126 are offset relative to the septum 5118 such that the primary and secondary lumens 5123, 5125 have different sizes.

[0169] 51E and 51F are distal-facing end and side views, respectively, of an aortic repair device 5100 in accordance with an additional embodiment of the present technology. Referring together to FIGS. 51E and 51F, in the illustrated embodiment, the septum 5118 includes a wedge-shaped section 5199 to provide a more oval cross-sectional shape to the primary and secondary lumens 5123, 5125 and help prevent the septum 5118 from dropping down into one lumen or the other. In some embodiments, the ends of the wedge-shaped section 5199 are sewn closed to prevent blood flow through the wedge-shaped section 5199. To hold the septum 5118 with the wedge-shaped ends properly open, the stent 5126 can be shaped to provide longitudinal struts at the apexes of the wedge-shaped sections 5199 to which the septum 5118 can be sewn, as shown in FIG. 51F.

[0170] The primary and secondary lumens 5123, 5125 are each configured (e.g., shaped, sized, and positioned) to receive a spanning member therein and / or thereabout when the base member 5110 is implanted in the aorta. Figure 51D is a distal-facing perspective end view of the aortic repair device 5100 of Figures 51A-C including first spanning member 5150a and second spanning member 5150b coupled to the base member 5110, for example, in accordance with an embodiment of the present technology. The spanning members 5150a-b can each include an expandable stent graft that is sized and shaped such that when the spanning members 5150a-b are coupled to / within the primary and secondary lumens 5123, 5125, respectively, and when the aortic repair device 5100 is implanted in the aorta, the spanning members 5150 engage and seal (i) with the septum 5118, (ii) with each other, and / or (iii) against the wall of the aorta.

[0171] More specifically, Figures 52A-C are side views of the aortic repair device 5100 of Figure 51D during different stages of implantation within the aorta, in accordance with an embodiment of the present technology. Referring initially to Figure 52A, the base member 5110 is first implanted within the proximal aorta (e.g., the ascending aorta and / or the aortic arch). The base member 5110 can be delivered to the aorta in a collapsed configuration within a catheter system (not shown). In some aspects of the present technology, omitting graft material from around the primary and secondary lumens 5123, 5125 by including only a septum 5118 can reduce the overall delivery profile of the base member 5110, potentially allowing the base member 5110 to be loaded into and delivered through a smaller catheter and / or delivered along a narrower intravascular delivery path.

[0172] 52B and 52C together, spanning members 5150a-b can then be delivered to and coupled to the base member 5110 over and / or within the primary and secondary lumens 5123, 5125 (FIG. 52A). The spanning members 5150a-b (e.g., proximal end portions thereof) can engage and seal against (i) the septum 5118 (FIG. 52A), (ii) each other, and / or (iii) the wall of the aorta to divert blood flow through the spanning members 5150a-b and past the diseased portion of the aorta. As shown in Figure 52A, in some embodiments, spanning members 5150a-b can be positioned parallel to one another in the aorta, with a first spanning member 5150a routing blood flow further through the aorta and a second spanning member 5150b routing blood flow from the aorta to a bifurcation vessel (e.g., the brachiocephalic artery, etc.). In other embodiments, as shown in Figure 52C, spanning members 5150a-b can be positioned crossing one another in the aorta, with a first spanning member 5150a routing blood flow from the aorta to a bifurcation vessel (e.g., the brachiocephalic artery, etc.) and a second spanning member 5150b routing blood flow further through the aorta.

[0173] 51A-52C together, in some embodiments, the septum 5118 is configured to promote sealing between the spanning members 5150 and inhibit leakage. FIGS. 53A and 53B are enlarged side and side perspective views, respectively, of the septum 5118 of the base member 5110 of FIGS. 51A-51C and one of the stents 5126, in accordance with an embodiment of the present technology. Referring together to FIGS. 53A and 53B, the septum 5118 can include a single sheet of graft material attached to the stent 5126 with transverse loops. The loops can provide an increased septum thickness, which promotes sealing and conformity with the spanning members 5150a-b (FIG. 51D). In some embodiments, an expandable foam can be placed inside the transverse loops of the graft material of the stent 5126, causing it to expand and seal further against the spanning members 5150a-b.

[0174] Similarly, Figures 54A-54C are enlarged side, perspective top, and side perspective views, respectively, of one of the septum 5118 and stents 5126 of the base member 5110 of Figures 51A-51C in accordance with an additional embodiment of the present technology. Referring together to Figures 54A-54C, the septum 5118 can include a single sheet of graft material that is attached to the stent 5126 along the V-pattern of the stent 5126 such that the septum 5118 has a corresponding folded or V-shape. Thus, septum 5118 can have a first end portion 5462 (e.g., a first free end portion) and a second end portion 5463 (e.g., a second free end portion) that can conform (e.g., mold, pinch, bend) inwardly against spanning members 5150a-b (FIG. 51D) to promote sealing and conforming with spanning members 5150a-b.

[0175] 51A-52C together, in some embodiments, the base member 5110 can include a plurality of septa defining three or more lumens therein that can each receive a corresponding spanning member. FIGS. 55A and 55B, for example, are cross-sectional and perspective end views, respectively, of a base member 5110 in accordance with additional embodiments of the present technology. Referring again to FIGS. 55A and 55B together, in the illustrated embodiment, the base member 5110 further includes a second septum 5564 extending between the first septum 5118 and one or more of the stents 5126. Thus, the first and second septa 5118, 5564 can define a primary lumen 5123, a first secondary lumen 5525a, and a second secondary lumen 5525b, which can each receive a different spanning member, for example, to perfuse a different bifurcation vessel or portion of the aorta. In other embodiments, the base member 5110 can include any number of lumens and / or the first and second septa 5118, 5564 can be positioned differently (e.g., offset) such that the lumens have different relative shapes and sizes.

[0176] 55C and 55D are perspective end views of a base member 5110 including a first spanning member 5550a, a second spanning member 5550b, and a third spanning member 5550c coupled thereto, in accordance with an embodiment of the present technology. The base member 5110 is in a relaxed configuration in FIG. 55C and in a radially compressed position in FIG. 55D. Referring together to FIG. 55C and FIG. 55D, the primary lumen 5123 receives the first spanning member 5550a therein, the first secondary lumen 5525a receives the second spanning member 5550b therein, and the second secondary lumen 5525b receives the third spanning member 5550c therein. As shown in FIG. 55D, the spanning members 5550a-c, even when radially compressed, are able to conform to one another and sealingly engage the first and second septa 5118, 5564 to inhibit openings (e.g., grooves, leak paths) therebetween.

[0177] 56A is an enlarged isometric end view of an aortic repair device 5600 in accordance with an embodiment of the present technology. In the embodiment shown, the aortic repair device 5600 includes a base member 5610 having a body portion 5612 including a septum 5618 that defines a primary lumen 5623 and a secondary lumen 5625. The aortic repair device 5600 further includes a separate leg member 5614 coupled to the body portion 5612 in the secondary lumen 5625. In some embodiments, the body portion 5612 is a stent graft including a proximal anchor stent 5626 and graft material 5628 that is attached to and extends distally from the proximal anchor stent 5626. That is, the body portion 5612 includes only the proximal anchor stent 5626 rather than including multiple stents spaced apart along its length.

[0178] 56B and 56C are side views of the aortic repair device 5600 of FIG. 56A during different stages of implantation within the aorta, in accordance with an embodiment of the present technology. Referring initially to FIG. 56B, the base member 5610 is first implanted in the proximal aorta (e.g., the ascending aorta, the aortic arch, and / or the aortic root) with the proximal anchor stent 5626 at least temporarily fixing the position of the base member 5610. The base member 5610 can be delivered to the aorta in a collapsed configuration within a catheter system (not shown). In some aspects of the present technology, including only the proximal anchor stent 5626 rather than multiple stents along the body portion 5612 can reduce the overall delivery profile of the base member 5610, potentially allowing the base member 5610 to be loaded into and delivered through a smaller catheter and / or along a narrower intravascular delivery path.

[0179] 56C, the leg members 5614 can then be coupled into the secondary lumen 5625 and sealingly engage the body portion 5612. In some embodiments, the radially outward force of the leg members 5614 and the proximal anchor stent 5626 can drive the graft material 5628 to engage and seal the aorta. Thus, the aortic repair device 5600 can route blood flow through a diseased portion of the aorta (e.g., an ascending aortic aneurysm) to one or more bifurcation vessels and the distal aorta.

[0180] V. Selected Embodiments of Aortic Repair Devices Having Multiple Components, E.g., for Complete Aortic Arch Repair Embodiments of the present technology (including one or more of the disclosed base members, spanning members, and / or other implants) can be combined to provide for the placement of an aortic repair device to treat all or substantially all of the entire proximal aorta (including, for example, the ascending aorta and the aortic arch). That is, the aortic repair device of the present technology can effectively reconstruct a portion of the proximal aorta and / or multiple aortic bifurcation vessels. Figures 57-65B are specific exemplary combinations of the disclosed technology for full-arch treatment. However, one skilled in the art will recognize that any of the devices and components described herein may be substituted in the exemplary combinations, and that other combinations are possible.

[0181] 57, for example, is a side view of an aortic repair device 5700 implanted in the aorta, in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 5700 includes a first base member 5710a implanted at least partially in the ascending aorta, a second base member 5710b implanted at least partially in the descending thoracic aorta, and a spanning member 5750 extending between and connecting the first and second base members 5710a-b. For example, the first base member 5710a can include a primary leg 5740a that sealingly engages and secures a proximal portion of the spanning member 5750 (e.g., as described in detail above with reference to FIGS. 43A-46), and the second base member 5710b can similarly include a primary leg 5740b that sealingly engages and secures a distal portion of the spanning member 5750. Thus, the spanning member 5750 can route blood flow distally through the aorta to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The first base member 5710a may further include a secondary leg 5714a extending into a first branch artery (e.g., the brachiocephalic artery) to perfuse the first branch artery, and the second base member 5710b may include a secondary leg 5714b extending into a second branch artery (e.g., the left subclavian artery) to perfuse the second branch artery.

[0182] In the illustrated embodiment, the aortic repair device 5700 further includes a bifurcation perfusion member 5766 that couples the spanning member 5750 to a third bifurcation artery (e.g., the left common carotid artery) for perfusing the third bifurcation artery. In some embodiments, the spanning member 5750 can be fenestrated (either prior to implantation or in situ after implantation) and the bifurcation perfusion member 5766 can be coupled thereto to provide a flow path to the third bifurcation artery. In other embodiments, the third bifurcation artery can be perfused via a bypass or via a spanning member connected to one or both of the base members 5710a-b.

[0183] In particular, in the illustrated embodiment, the second base member 5710b is implanted in an inverted or flipped orientation relative to the first base member 5710a and is substantially similar to the first base member 5710. Thus, a "distal" portion of the first base member 5710a corresponds to a "proximal" portion of the second base member 5710b, and vice versa. Thus, one skilled in the art will understand that the use of the terms "proximal" and "distal" is based on the orientation of the base members 5710a-b, and that a "distal" component of one of the base members 5710a-b can correspond to a "proximal" component of the other of the base members 5710a-b, and vice versa.

[0184] 58A is a side view of an aortic repair device 5800 implanted in the aorta in accordance with an additional embodiment of the present technology. In the illustrated embodiment, the aortic repair device 5800 includes a first base member 5810a implanted at least partially in the ascending aorta, a second base member 5810b implanted at least partially in the descending thoracic aorta, and a spanning member 5850 extending between and connecting the first and second base members 5810a-b. For example, the first base member 5810a can include a primary internal lumen defined by a septum (e.g., as described in detail with reference to FIGS. 3A-42D ) that sealingly engages and secures a proximal portion of the spanning member 5850, and the second base member 5810b can similarly include a primary internal lumen defined by a septum that sealingly engages and secures a distal portion of the spanning member 5850. Thus, the spanning member 5850 can route blood flow distally through the aorta to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The first base member 5810a may further include a leg 5814a that extends into a first branch artery (e.g., the left subclavian artery) to perfuse the first branch artery, and the second base member 5810b may include a leg 5814b that extends into a second branch artery (e.g., the brachiocephalic artery) to perfuse the second branch artery. In the illustrated embodiment, a third branch artery (e.g., the left common carotid artery) includes a surgical block near the aorta and is perfused via a bypass between the first and third branch arteries. In some aspects of the present technology, a crisscross or overlapping arrangement of the legs 5814a-b may be easier to achieve during delivery than embodiments in which the legs 5814a-b perfuse the nearest supra-aortic bifurcation artery due to the take-off angle of the bifurcation artery from the aorta and / or the delivery path required.

[0185] FIG 58B is a side view of the aortic repair device 5800 of FIG 58A implanted in the aorta in a different configuration in accordance with an embodiment of the present technology. In the illustrated embodiment, the first base member 5810a is at least partially implanted in the ascending aorta and the second base member 5810b is at least partially implanted in the descending thoracic aorta, with the spanning member 5850 extending between and connecting the first and second base members 5810a-b. However, in the illustrated embodiment, the leg 5814a of the first base member 5810a extends into the brachiocephalic artery to perfuse the brachiocephalic artery, and the leg 5814b of the second base member 5810b extends into the left common carotid artery to perfuse the left common carotid artery. In some embodiments, a surgical block is created in the left subclavian artery near the aorta and perfused via a bypass between the left common carotid artery and the left subclavian artery. In some embodiments, a first stent 5830a can be at least partially implanted in the first leg 5814a and maintain a lumen therethrough, and a second stent 5830b can be at least partially implanted in the second leg 5814b and maintain a lumen therethrough.

[0186] FIG 58C is a side view of the aortic repair device 5800 of FIG 58B implanted in the aorta and including an additional extension member 5896 in accordance with an embodiment of the present technology. In the illustrated embodiment, the extension member 5896 (which may also be referred to as an extender, cuff, anchor, and / or seal, etc.) is coupled to and / or positioned within a proximal end portion 5811a of the first base member 5810a. More specifically, the extension member 5896, which may be a stent graft or other device, may be positioned at least partially within a body portion 5812a of the first base member 5810a and extend proximally from the body portion 5810a toward the aortic valve. For example, the first base member 5810a can include a septum 5818a that extends only partially through the first body portion 5818a (e.g., as described in detail above with reference to Figures 5A-8H) such that the extension member 5896 fits around the entire interior circumference of the first body portion 5810a at and adjacent to the proximal end portion 5811a of the first body portion 5810a.

[0187] The extension member 5896 can be in sealing engagement with (i) the body portion 5812a within a lumen (e.g., a primary lumen) of the body portion 5812a and (ii) the aorta proximal to the first base member 5810, defining a continuous blood flow path through the extension member 5896 and the first base member 5810a. The extension member 5896 can be implanted during the same procedure as the first base member 5810a or during a separate (e.g., later) procedure and is configured to extend the sealing engagement of the aortic repair device 5800 in the aorta. Alternatively or additionally, the extension member 5896 can help anchor the first base member 5810a in the aorta. In some such embodiments, the extension member 5896 can be a bare stent that does not sealingly engage the aorta. In some embodiments, the extension member 5896 (or one or more additional extension members 5896) can be coupled to a distal end portion 5811b of the body portion 5812b of the second base member 5810b, coupled to an end portion 5817a of the leg portion 5814a of the first base member 5810a in the brachiocephalic artery (or another branch vessel), and / or coupled to an end portion 5817b of the leg portion 5814b of the second base member 5810b in the left common carotid artery (or another branch vessel) to provide extended sealing and / or anchoring.

[0188] FIG. 59 is a side view of an aortic repair device 5900 in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 5900 includes (i) a first base member 5910a having a leg 5914a and configured to be implanted at least partially in the ascending aorta, and (ii) a second base member 5910b having a leg 5914b and configured to be implanted at least partially in the descending thoracic aorta. The aortic repair device 5900 further includes a spanning member 5950 extending between and configured to connect the first and second base members 5910a-b. In the illustrated embodiment, the spanning member 5950 has enlarged side portions and a reduced diameter middle portion, as described in detail above with reference to FIG. 21. In other embodiments, the spanning member 5950 can have other configurations described herein. For example, spanning member 5950 can have a generally constant diameter, as described in detail above with reference to Figures 13A-14B. Aortic repair device 5900 further includes (i) a first stent 5930a and (ii) a second stent 5930b, where first stent 5930a is optionally implanted within legs 5914a of first base member 5910a and configured to help maintain the shape and patency of a lumen therethrough, and second stent 5930b is optionally implanted within legs 5914b of second base member 5910b and configured to help maintain the shape and patency of a lumen therethrough.

[0189] In some embodiments, the aortic repair device 5900 further includes an extension member 5996 coupled to the first base member 5910a and configured to provide extended sealing and / or anchoring in the ascending aorta. The aortic repair device 5900 can further include an additional extension member (not shown) coupled to the second base member 5910b and configured to provide extended sealing and / or anchoring in the descending aorta. In the illustrated embodiment, the aortic repair device 5900 further includes an extender stent graft 5997 coupled to the leg 5914a of the first base member 5910a and configured to provide extended sealing and / or anchoring in, for example, the aorta and / or bifurcation arteries (such as, for example, the brachiocephalic artery). The aortic repair device 5900 may further include an additional extender stent graft (not shown) coupled to the leg 5914b of the second base member 5910b and configured to provide extended sealing and / or anchoring within the aorta and / or bifurcation arteries (e.g., the left common carotid artery, etc.).

[0190] 60A is a side view of an aortic repair device 6000 implanted in the aorta, according to an additional embodiment of the present technology. In the illustrated embodiment, the aortic repair device 6000 includes a base member 6010 at least partially implanted in the ascending aorta and a spanning member 6050 coupled to the base member 6010 and extending through the aortic arch into the descending aorta. The base member 6010 can include a primary inner lumen defined by a septum (e.g., as described in detail with reference to FIGS. 3A-38B ), which sealingly engages and secures a proximal portion of the spanning member 6050. Thus, the spanning member 6050 can route blood flow distally through the aorta to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The base member 6010 may further include a leg portion 6014 that extends into a first branch artery (eg, the brachiocephalic artery) to perfuse the first branch artery.

[0191] In the illustrated embodiment, the aortic repair device 6000 further includes a first parallel member 6068a and a second parallel member 6068b, which extend from the aorta to a second and third bifurcation artery (e.g., the left common carotid artery and the left subclavian artery), respectively. The first and second parallel members 6068a-b can include expandable stent grafts and can be disposed at least partially parallel to the spanning member 6050 (e.g., extending next to each other). In some embodiments, the spanning member 6050 and the first and second parallel members 6068a-b can conform to each other and to the wall of the aorta to circumferentially seal the aorta such that blood does not flow substantially between them and is contained within the spanning member 6050 and the first and second parallel members 6068a-b. Thus, blood can flow retrogradely from the distal exit of the spanning member 6050, into and through the first and second parallel members 6068a-b, and into the left subclavian and left common carotid arteries to perfuse these vessels. In some aspects of the present technology, intravascular delivery and placement of the spanning member 6050 and the first and second parallel members 6068a-b in a parallel arrangement can be relatively easier than docking / attaching these components to a distal base member.

[0192] 60B and 60C are cross-sectional views of the aortic repair device 6000 and the aorta taken along line 60B-60B of FIG. 60A in accordance with an embodiment of the present technology. FIG. 60B illustrates a first configuration of the spanning member 6050 and the first and second parallel members 6068a-b to inhibit leakage (e.g., groove leakage) therebetween. In the illustrated embodiment, the first and second parallel members 6068a-b each have a circular cross-sectional shape, and the spanning member 6050 has a generally circular cross-section including a first channel (e.g., cutout, recess) 6067a and a second channel 6067b that are shaped to receive the first and second parallel members 6068a-b, respectively, therein. Thus, the spanning member 6050 and the first and second parallel members 6068a-b together can define a generally circular cross-sectional shape for engaging and sealing the aorta.

[0193] FIG. 60C illustrates a second configuration of the spanning member 6050 and the first and second parallel members 6068a-b to inhibit leakage therebetween. In the illustrated embodiment, the first and second parallel members 6068a-b each have a circular cross-sectional shape, and the spanning member 6050 is formed to be more flexible / compliant than the first and second parallel members 6068a-b, allowing the spanning member 6050 to conform around the more rigid first and second parallel members 6068a-b. In some embodiments, the aortic repair device 6000 can further include a filler material 6069 at least partially around / between the spanning member 6050 and the first and second parallel members 6068a-b, which seals the interface therebetween. The filler material 6069 can be a foam, hydrogel, and / or other suitable material that is impermeable to blood.

[0194] In some embodiments, multiple base members of the aortic repair device can be nested together to treat all or substantially all of the entire proximal aorta (e.g., including the ascending aorta and the aortic arch). Figures 61A-61F are side views (e.g., fluoroscopic images) of various stages of a procedure for implanting an aortic repair device 6100 in a patient's aorta, for example, in accordance with an embodiment of the present technology.

[0195] Referring initially to FIG. 61A, a first base member 6110a can be implanted in the ascending aorta, for example, via a first catheter 6101. In some embodiments, the first catheter 6101 can be advanced into the ascending aorta through the brachiocephalic artery and / or via a transapical approach. The first base member 6110a can include a body portion 6112a positioned in the aorta, a leg portion 6114a extending from the body portion 6112a into a first bifurcation artery (e.g., the brachiocephalic artery, etc.), and a septum (e.g., as described in detail with reference to FIGS. 3A-38B), which extends fully or partially through the body portion 6112a and defines (i) a primary lumen for blood flow through the body portion 6112a to the aorta, and (ii) a secondary lumen for blood flow through the body portion 6112a to the leg portion 6114a and the first bifurcation artery.

[0196] 61B, a second catheter 6102 containing (e.g., housing, constraining) a second base member 6110b can be advanced into the primary lumen of its body portion 6112a toward the first base member 6110a. In some embodiments, the second catheter 6102 can be advanced through a second bifurcation artery (such as the left common carotid artery) and into the aorta (e.g., via a transcarotid approach).

[0197] 61C, the second catheter 6102 can be withdrawn relative to the second base member 6110b to place the second base member 6110b within the first base member 6110a in the aorta. More specifically, the body portion 6112b of the second base member 6110b can be placed at least partially within the primary lumen of the first base member 6110a, and the leg portion 6114b of the second base member 6110b can be placed in a second bifurcation artery (e.g., the left common carotid artery). The body portion 6112b of the second base member 6110b can include a septum that extends completely or partially through the body portion 6112b to define (i) a primary lumen for blood flow through the body portion 6112b to the aorta and (ii) a secondary lumen for blood flow through the body portion 6112b to the leg 6114b and the second bifurcation artery. The septum of the body portion 6112a and the first base member 6110a can sealingly engage and secure a proximal portion of the body portion 6112b of the second base member 6110b. In some embodiments, the second base member 6110b has a smaller diameter than that of the first base member 6110a. In some embodiments, the body portion 6112b of the second base member 6110b extends distally from the body portion 6112a of the first base member 6110a, extending a sealing zone of the aortic repair device 6100 into the aorta along the ascending aorta and / or the aortic arch.

[0198] 61D, the third base member 6110c can be delivered via a third catheter (not shown) and implanted within the second base member 6110b in the aorta, for example, via a third bifurcation artery (e.g., the left subclavian artery, etc.). More specifically, the body portion 6112c of the third base member 6110c can be placed at least partially within the primary lumen of the second base member 6110b, and the leg portion 6114c of the third base member 6110c can be placed within the third bifurcation artery (e.g., the left subclavian artery). The body portion 6112c of the second base member 6110c can include a septum that extends completely or partially through the body portion 6112c to define (i) a primary lumen for blood flow through the body portion 6112c to the aorta and (ii) a secondary lumen for blood flow through the body portion 6112c to the leg 6114c and the third bifurcation artery. The body portion 6112b of the second base member 6110b and the septum can sealingly engage and secure a proximal portion of the body portion 6112c of the third base member 6110c. In some embodiments, the third base member 6110c has a smaller diameter than that of the first base member 6110a and the second base member 6110b. In some embodiments, the body portion 6112c of the third base member 6110c extends distally from the body portion 6112b of the second base member 6110b, extending a sealing zone of the aortic repair device 6100 into the aorta along the ascending aorta and / or the aortic arch.

[0199] 61E, a fourth catheter 6103 containing (e.g., housing, restraining) a spanning member 6150 can be advanced into the primary lumen of its body portion 6112c toward the third base member 6110c. In some embodiments, the fourth catheter 6103 can be advanced through the descending aorta.

[0200] As shown in FIG. 61F, a fourth catheter 6103 (FIG. 61E) can be withdrawn relative to the spanning member 6150 to place the spanning member 6150 within the aorta and into the third base member 6110c. The body portion 6112c and a septum of the third base member 6110c can sealingly engage and secure a proximal portion of the spanning member 6150. The spanning member 6150 can extend along the aortic arch into the descending aorta and route blood flow distally through the aorta (e.g., to the descending thoracic aorta) past a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). Referring together to Figures 61A-61F, the aortic repair device 6100 is capable of providing a full-arch treatment, in which (i) the leg 6114a of the first base member 6110a directs blood flow to a first branch artery (e.g., the brachiocephalic artery), (ii) the leg 6114b of the second base member 6110b directs blood flow to a second branch artery (e.g., the left common carotid artery), (iii) the leg 6114c of the third base member 6110c directs blood flow to a third branch artery (e.g., the left subclavian artery), (iv) the primary lumens of the first through third base members 6110a-c direct blood flow to the spanning member 6150, and (v) the spanning member 6150 directs blood flow into the descending aorta.

[0201]

[00136] Figures 62A and 62B provide schematic illustrations of the aortic repair device 6100 of Figures 61A-61F implanted in the aorta in accordance with an embodiment of the present technology. Specifically, Figure 62B is an exploded view of the various components of the aortic repair device 6100 illustrating their relative overlap from a proximal to distal direction, and Figure 62A is a side view of the aorta illustrating where the various components shown in Figure 62A are implanted in the aorta. For example, as shown in Figure 62B, the first base member 6110a has a proximal end portion or opening labeled as "1A", a distal end portion defining an opening or exit to a primary lumen labeled as "1B", and a leg portion defining a distal opening or exit to a secondary lumen labeled as "1C". These components of the first base member 6110a are configured to be implanted in the aorta shown in Fig. 62A at the corresponding locations of the reference labels shown in Fig. 62A. For example, the proximal opening of the body portion 6112 (labeled "1A" in Fig. 62B) is configured to be implanted in the ascending aorta as shown by reference label "1A" in Fig. 62A, the distal opening of the body portion 6112 (labeled "1B" in Fig. 62B) is configured to be implanted in the ascending aorta and / or proximal to the aortic arch distally from the proximal opening as shown by reference label "1B" in Fig. 62A, and the distal opening of the leg portion (labeled "1C" in Fig. 62B) is configured to be implanted in the brachiocephalic trunk as shown by reference label "1C" in Fig. 62A. The various portions of the second base member 6110b, the third base member 6110c, and the spanning member 6150 are similarly labeled in Figures 61A and 61B. Accordingly, the reference labels shown in Figure 62A illustrate the relative positioning and / or overlap of corresponding portions of the base members 6110a-c and the spanning members 6150 when the aortic repair device 6100 is implanted in the aorta.

[0202] 61A and 61B together, in some embodiments, when the aortic repair device 6100 is implanted in the aorta, at least a portion of each of the base members 6110a-c and the spanning members 6150 can at least partially overlap (e.g., nested within one another), such as along line O shown in FIG. 62B. Thus, the aortic repair device 6100 can have four layers of stents along this region, which can make the aortic repair device 6100 relatively stiff. In some embodiments, the stents of one or more of the base members 6110a-c and / or spanning members 6150 can be configured for increased flexibility and / or reduced thickness along such overlap regions to reduce the total material of the aortic repair device 6100 and / or to reduce the stiffness of the aortic repair device 6100.

[0203] For example, Figures 63A and 63B provide schematic illustrations of the aortic repair device 6100 of Figures 61A-61F implanted in the aorta according to additional embodiments of the present technology. The various positionings indicated by the reference labels (e.g., "1A", "1B", etc.) can be the same as those shown in Figures 61A-62B and described in detail with reference to Figures 61A-62B. In the illustrated embodiment, base members 6110a-c each have a stent 6326 along their body, which can have a reduced diameter compared to that shown in Figures 62A and 62B. In some aspects of the present technology, the reduced diameter stent 6326 can reduce the total material (e.g., metal) of the aortic repair device 6100 and / or increase the relative flexibility of the aortic repair device 6100 while also providing sufficient radial strength to deploy and release the base members 6100a-c. In some embodiments, the spanning member 6150 can similarly include a reduced diameter stent, such as in the overlap region indicated by line O.

[0204] Similarly, Figures 64A and 64B provide schematic illustrations of the aortic repair device 6100 of Figures 61A-61F implanted in the aorta in accordance with additional embodiments of the present technology. The various positionings indicated by the reference labels (e.g., "1A", "1B", etc.) can be the same as shown in Figures 61A-62B and described in detail with reference to Figures 61A-62B. In the illustrated embodiment, base members 6110a-c each have a single reduced diameter stent 6326 at their distal end portions and further include a section 6428 of unsupported graft material where the stent is omitted compared to the embodiment shown in Figures 62A-63B. In some aspects of the present technology, omitting the stent in section 6428 of graft material can reduce the total material (e.g., metal) of aortic repair device 6100 and / or increase the relative flexibility of aortic repair device 6100, while the remaining stent provides sufficient radial strength for deploying and releasing base members 6100a-c. Additionally, as shown in FIG. 64B, section 6428 of graft material can be selected such that aortic repair device 6100 has at least two stent layers in each section of aortic repair device 6100 (e.g., in the overlap region indicated by line O, etc.). In some embodiments, spanning member 6150 can similarly include a reduced diameter stent and / or unsupported section of graft material, such as, for example, in the overlap region indicated by line O.

[0205] FIG. 65A is a side view of an aortic repair device 6500 implanted in the ascending aorta in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 6500 includes a first base member 6510a at least partially implanted in the ascending aorta and a second base member 6510b coupled to the first base member 6510a and extending proximally from the first base member 6510a. The base members 6510a-b can each include a primary inner lumen defined by a septum (e.g., as described in detail with reference to FIGS. 3A-42D) and a first leg 6514a and a second leg 6514b, respectively. The base members 6510a-b can conform and seal against the aorta. At least a portion of the second base member 6510b can extend into and seal against at least a portion of the first base member 6510a. For example, the second leg 6514b can extend at least partially into the first leg 6514a or a secondary lumen connected thereto. The first leg 6514a can extend into the first bifurcation artery (e.g., the brachiocephalic artery) to perfuse the first bifurcation artery. Thus, the second base member 6510b can route blood into the first base member 6510a, which routes blood through the first leg 6514a into the first bifurcation artery and distally through the aorta. In some aspects of the present technology, the first base member 6510a can be placed before the second base member 6510b, and then the second base member 6510b can be placed at least partially into the first base member 6510a to extend the sealing range of the aortic repair device 6500. In an additional aspect of the present technology, placing the second base member 6510b at least partially within the first base member 6510a can improve placement accuracy and control of the second base member 6510b.

[0206] Similarly, FIG. 65B is a side view of an aortic repair device 6500 implanted in the descending aorta according to an additional embodiment of the present technology. In the illustrated embodiment, the second base member 6510b can similarly improve the sealing range of the aortic repair device 6500 in the descending aorta while also having improved placement and precision and control from being placed in the first base member 6510a. The first base member 6510a can be positioned to perfuse a second bifurcation artery (e.g., the left subclavian artery) via the first arm 6514a. In some embodiments, a spanning member can be coupled between the aortic repair device 6500 shown in FIG. 65A and FIG. 65B to completely repair the aortic arch.

[0207] VI. SELECTED ADDITIONAL EMBODIMENTS OF AORTIC REPAIR DEVICES HAVING REDUCED DELIVERY PROFILE 66A-69B illustrate additional embodiments of an aortic repair device including (i) a dock or base member configured to be implanted in the aorta and (ii) multiple spanning members configured to "dock" to the base member to provide different blood flow paths to the distal aorta and / or bifurcation arteries. The various aortic repair devices can include some features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of the aortic repair devices described in detail above with reference to each other and / or to Figures 3A-65B, and can operate in a generally similar or identical manner to each other and / or to the aortic repair devices described with reference to Figures 3A-65B.

[0208] FIG. 66A is a side view of an aortic repair device 6600 implanted in the aorta according to an additional embodiment of the present technology. FIG. 66B is a cross-sectional view of the aortic repair device 6600 taken along line 66B-66B of FIG. 66A according to an additional embodiment of the present technology. Referring together to FIG. 66A and FIG. 66B, the aortic repair device 6600 includes a dock or base member 6610 implanted at least partially in the ascending aorta and a plurality of spanning members 6650 (individually identified as first through fourth spanning members 6650a-6650d, respectively) coupled (e.g., docked) to the base member 6610. The base member 6610 and the spanning members 6650 can each include an expandable stent graft. In the illustrated embodiment, each of the spanning members 6650 includes a proximal end portion positioned within the base member 6610.

[0209] In some embodiments, the base member 6610 defines a plurality of lumens (e.g., separated by one or more septa of graft material) each configured to receive and secure a corresponding one of the spanning members 6650. In some embodiments, the base member 6610 includes a circular ring defining a single lumen, with the spanning members 6650 positioned therein in a parallel arrangement. In some embodiments, one or more of the spanning members 6650 can be integrally formed with the base member 6610 (e.g., can include integral "legs"). For example, in the illustrated embodiment, the second spanning member 6650b is integrally formed with the base member 6610.

[0210] In the illustrated embodiment, the outer surface of the base member 6610 engages and seals with the wall of the aorta, sealing the aorta circumferentially. The spanning members 6650 can engage and / or conform to each other and to the inner surface of the base member 6610 such that blood does not flow substantially between them and is contained within the spanning members 6650. Thus, blood can flow antegradely through each of the spanning members 6650. In the illustrated embodiment, the first spanning member 6650a has a larger cross-sectional area than each of the second through fourth spanning members 6650b-d and routes blood flow distally through the aorta (e.g., to the descending thoracic aorta) to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The second through fourth spanning members 6650b-d extend from the base member 6610 to the brachiocephalic artery, left common carotid artery, and left subclavian artery, respectively, and route blood flow thereto for perfusing those vessels. In some aspects of the present technology, the aortic repair device 6600 is configured to perfuse each of the distal aorta and upper aortic bifurcation vessels with antegrade blood flow, which can help improve volumetric flow through these vessels and ensure adequate perfusion.

[0211] FIG. 67A is a side view of an aortic repair device 6700 implanted in the aorta in accordance with an additional embodiment of the present technology. FIG. 67B is a cross-sectional view of the aortic repair device 6700 taken along line 67B-67B of FIG. 67A in accordance with an additional embodiment of the present technology. Referring together to FIG. 67A and FIG. 67B, the aortic repair device 6700 includes a dock or base member 6710 that is at least partially implanted in the descending thoracic aorta and a plurality of spanning members 6750 (individually identified as first through fourth spanning members 6750a-6750d, respectively) that are coupled (e.g., docked) to the base member 6710. Each of the spanning members 6750 can include a distal end portion positioned within the base member 6710. The base member 6710 can include one or more lumens for receiving distal end portions of the spanning members 6750 and / or one or more of the spanning members 6750 can be integrally formed with the base member 6710. For example, in the illustrated embodiment, the second spanning member 6750b is integrally formed with the base member 6710.

[0212] In the illustrated embodiment, the outer surface of the base member 6710 engages and seals with the wall of the aorta, sealing the aorta circumferentially. Distal end portions of the spanning members 6750 can engage and / or conform to each other and to the inner surface of the base member 6710 such that blood does not flow substantially between them and is contained within the spanning member 6750. In the illustrated embodiment, the first spanning member 6750a has a larger cross-sectional area than each of the second through fourth spanning members 6750b-d and has a proximal end portion positioned within the ascending aorta. The first spanning member 6750a can engage and seal against the wall of the ascending aorta such that blood flows antegrade therethrough toward the base member 6710. Thus, the first spanning member 6750a can route blood flow distally through the aorta (e.g., to the descending thoracic aorta) to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). Blood can then flow retrogradely into and through second to fourth spanning members 6750b-d, which extend from base member 6710 to the brachiocephalic, left common carotid, and left subclavian arteries, respectively, routing blood flow thereto for perfusing those vessels. In some aspects of the present technology, base member 6710 and / or spanning member 6750 can be delivered via a transfemoral approach because base member 6710 is not positioned in the proximal aorta and therefore spanning member 6750 does not need to be "docked" to base member 6710 in the proximal aorta.

[0213] FIG 60A is a side view of an aortic repair device 6000 implanted in the aorta in accordance with an additional embodiment of the present technology. FIG 60B is a cross-sectional view of the aortic repair device 6000 taken along line 60B-60B of FIG 60A in accordance with an additional embodiment of the present technology. Referring together to FIG 60A and FIG 60B, the aortic repair device 6000 includes a dock or base member 6010 that is at least partially implanted in the ascending aorta and a plurality of spanning members 6050 (individually identified as first to third spanning members 6050a-6050c, respectively) that are coupled (e.g., docked) to the base member 6010. Each of the spanning members 6050 can include a proximal end portion that is positioned within the base member 6010.

[0214] In the illustrated embodiment, the base member 6810 defines a primary lumen 6823, a first secondary lumen 6825a, and a second secondary lumen 6825b. In some embodiments, as shown in FIG. 68B, the base member 6810 includes one or more fabric septa extending therethrough that define the primary lumen 6823, the first secondary lumen 6825a, and / or the second secondary lumen 6825b. In the illustrated embodiment, the second spanning member 6850b is integrally formed with the base member 6810 such that the first secondary lumen 6825a extends continuously therethrough. The first spanning member 6850a includes a proximal end portion that is positioned at least partially within the primary lumen 6823 and configured (e.g., shaped, sized) to conform and seal against its periphery. Similarly, the third spanning member 6850c includes a proximal end portion that is positioned at least partially within the second secondary lumen 6825b and configured (e.g., shaped, sized) to conform and seal against the periphery thereof. Thus, the spanning member 6850 can engage and / or conform to the periphery of the lumens 6823, 6825a, 6825b and the base member 6810 such that blood does not flow substantially therebetween and is contained within the spanning member 6850. An outer surface of the base member 6810 engages and seals with the wall of the aorta, sealing the aorta circumferentially. Thus, blood can flow antegradely through each of the spanning members 6850.

[0215] In the illustrated embodiment, the first spanning member 6850a has a larger cross-sectional area than the second and third spanning members 6850b-c, routing blood flow distally through the aorta (e.g., to the descending thoracic aorta) to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The second and third spanning members 6850b-c extend from the base member 6810 to the brachiocephalic trunk and left common carotid artery, respectively, routing blood flow thereto for perfusing those vessels. In some embodiments, the left subclavian artery can be perfused via a surgical bypass or another implant connected to one or more of the components of the aortic repair device 6800.

[0216] FIG 69A is a side view of an aortic repair device 6900 implanted in the aorta in accordance with an additional embodiment of the present technology. FIG 69B is a cross-sectional view of the aortic repair device 6900 taken along line 69B-69B of FIG 69A in accordance with an additional embodiment of the present technology. Referring together to FIG 69A and FIG 69B, the aortic repair device 6900 includes a dock or base member 6910 that is at least partially implanted in the ascending aorta and a plurality of spanning members 6950 (individually identified as first to third spanning members 6950a-6950c, respectively) that are coupled (e.g., docked) to the base member 6910. Each of the spanning members 6950 can include a proximal end portion that is positioned within the base member 6910.

[0217] In the illustrated embodiment, the base member 6910 defines a primary lumen 6923, a first secondary lumen 6925a, and a second secondary lumen 6925b. In the illustrated embodiment, each of the spanning members 6950 is a separate component that can be modularly coupled to the base member 6910 (e.g., none of the spanning members 6950 are integrally formed with the base member 6910). The first through third spanning members 6950a-c each include a proximal end portion that is positioned at least partially within and configured (e.g., shaped, sized) to fit and seal against the surroundings of the primary lumen 6923, the first secondary lumen 6925a, and the second secondary lumen 6925b, respectively. Thus, the spanning member 6950 can engage and / or conform around the lumens 6923, 6925a, 6925b and the base member 6910 such that blood does not flow substantially between them and is contained within the spanning member 6950. The outer surface of the base member 6910 engages and seals with the wall of the aorta, sealing the aorta circumferentially. Thus, blood can flow antegradely through each of the spanning members 6950. In some aspects of the present technology, forming the spanning member 6950 as a separate component that is not integrally attached to the base member 6910 can reduce the profile of the base member 6910, thereby allowing the base member 6910 to be placed through a smaller delivery catheter and / or a narrower delivery pathway (e.g., via a transcarotid approach rather than a transfemoral approach).

[0218] In the illustrated embodiment, the first spanning member 6950a has a larger cross-sectional area than the second and third spanning members 6950b-c and routes blood flow distally through the aorta (e.g., to the descending thoracic aorta) to pass through a diseased portion of the aorta (e.g., an aortic arch aneurysm, etc.). The second and third spanning members 6950b-c extend from the base member 6910 to the brachiocephalic trunk and left common carotid artery, respectively, and route blood flow thereto for perfusing those vessels. In some embodiments, the left subclavian artery can be perfused via a surgical bypass or another implant connected to one or more of the components of the aortic repair device 6900.

[0219] VII. SELECTED ADDITIONAL EMBODIMENTS OF ANCHORING FEATURES FOR ANCHORING AORTIC REPAIR DEVICES 70-74B illustrate additional embodiments of aortic repair devices including anchoring features for inhibiting proximal migration of the aortic repair device through the aorta. The illustrated aortic repair devices can include several features that are at least generally similar in structure and function (or identical in structure and function) to corresponding features of the aortic repair devices described in detail above with reference to each other and / or with reference to FIGS. 3A-61B, and can operate in a generally similar or identical manner to each other and / or the aortic repair devices described with reference to FIGS. 3A-69B. Similarly, any of the anchoring features or other features described in detail with reference to FIGS. 70-74B can be incorporated into the aortic repair devices of FIGS. 3A-61B.

[0220] 70 is a side view of an aortic repair device 7000 implanted in the aorta in accordance with an embodiment of the present technology. In the illustrated embodiment, the aortic repair device 7000 includes a dock or base member 7010 that is at least partially implanted in the ascending aorta. The base member 7010 can include an expandable stent graft configured to expand and seal around a diseased portion of the aorta and define one or more lumens for modularly receiving one or more spanning members to route blood flow through the aorta and / or distally to one or more supra-aortic bifurcation vessels. More specifically, the base member 7010 includes a tubular body portion 7012 configured to expand within and seal against the aorta.

[0221] In the illustrated embodiment, the base member 7010 further includes an anchor 7070 (e.g., root anchor, proximal anchor) extending proximally from the proximal end portion 7011 of the body portion 7012. In some embodiments, the anchor 7070 includes a wire form having a "hoop-like" shape with a larger expanded diameter than the body portion 7012. The anchor 7070 extends at least partially into the aortic root and is capable of anchoring the body portion 7012 in an appropriate location within the proximal aorta. The aortic root is typically bulbous and has a larger maximum diameter than a healthy ascending aorta. The sinotubular junction is the junction between the distal end of the aortic root and the proximal end of the ascending aorta, and is known to have "tougher" tissue compared to the tissue on either side of it (e.g., the annulus fibrosus). Thus, in some aspects of the present technology, the anchor 7070 can at least partially engage the sino-ascending junction and provide a sturdy anchor point for the base member 7010, which inhibits or even prevents proximal migration of the body portion 7012. In some embodiments, the anchor 7070 can include an opening or arch 7071 around the commissures of the aortic valve to provide space for the commissures to slip in such that the aortic valve features are not included.

[0222] In the illustrated embodiment, the anchor 7070 includes a plurality of elongated hoop-like shapes spaced circumferentially around the body portion 7012. In other embodiments, the anchor 7070 can have other shapes. For example, FIG. 71 is a side view of an aortic repair device 7000 implanted in the aorta and including an anchor 7170 in accordance with an additional embodiment of the present technology. In the illustrated embodiment, the anchor 7170 is a wire form including a plurality of small flared loops that engage the sino-ascending aorta junction. As shown in FIG. 71, these flared wire loops can be extensions of the wire loop that form the tubular shape of the body portion 7010, thereby providing the flared wire loop with additional strength for engaging the sino-ascending aorta junction.

[0223] 72A and 72B are enlarged isometric side views of a base member 7210 of an aortic repair device in accordance with an embodiment of the present technology. Referring together to FIGS. 72A and 72B, the base member 7210 includes a tubular body 7212 having a proximal end portion 7211 and an anchor 7270 coupled to the proximal end portion 7211 of the body 7212. In the illustrated embodiment, the anchor 7270 is a circular member (such as, for example, a ring stent formed from Nitinol wire) having a diameter D1 that is greater than the diameter D2 of the body 7212. The anchor 7270 can be attached to the proximal end portion 7211 of the body 7212 by directly attaching it to an edge thereof (e.g., via stitching 7273) as shown in FIG. 72A or by being positioned in a pocket 7274 as shown in FIG. 72B. The body portion 7212 can include an expandable graft material or stent graft that is configured to expand and seal around the diseased portion of the aorta and defines one or more lumens for modularly receiving one or more spanning members to route blood flow through the aorta and / or distally to one or more supra-aortic bifurcation vessels. The anchor 7270 is configured (e.g., sized and shaped) to engage the sino-ascending aorta junction when the base member 7210 is implanted in the aorta to anchor the body portion 7212 and inhibit or even prevent distal migration of the body portion 7212. In some aspects of the present technology, the base member 7210 can have a windsock shape when implanted in the aorta.

[0224] The anchor 7270 can include a continuous ring or an open ring (e.g., a pair of free ends, including a slot therethrough) and can be folded for loading into a delivery catheter system. For example, FIG. 73A includes an end view illustrating sequential folding of the anchor 7270 for loading into a delivery catheter system when the anchor 7270 includes a closed ring, in accordance with an embodiment of the present technology. As shown, the anchor 7270 can be folded into a figure eight shape to fold the anchor 7270 into a smaller delivery profile. Similarly, FIG. 73B includes an end view illustrating sequential folding of the anchor 7270 for loading into a delivery catheter system when the anchor 7270 includes an open ring, in accordance with an embodiment of the present technology. As shown, the anchor 7270 can include a pair of opposing free ends 7375 that can be moved relative to one another to coil the anchor 7270 into a smaller delivery profile.

[0225] 74A and 74B are enlarged isometric side views of the base member 7210 of FIG. 72B in accordance with an embodiment of the present technology. Referring together to FIGS. 74A and 74B, in some embodiments, the anchor 7270 includes an open ring that is positioned in the pocket 7274 by being advanced through a channel 7476 ( FIG. 74A ) in the body portion 7212 and around the pocket 7274 ( FIG. 74B ) while in an elongated state. In some embodiments, a pushing element 7477 and / or a pulling element 7478 can be attached to the proximal and distal ends of the anchor, respectively, and can be used to advance the anchor 7270 through the channel 7476 and around the pocket 7274. The anchor 7270 can be delivered to the pocket 7274 before or after the body portion 7212 is implanted in the aorta.

[0226] Additional means of anchoring to the aortic wall can be used with the base members of the device described in Figures 70-74B, or the base members described in Figures 3-69B, or any of the other spanning members, parallel members, or other elements described herein. Anchors that pierce the aortic wall (such as the Heli-FX device manufactured by Medtronic) can additionally be used. The proximal end of any of the base members described herein (including the flared end of the base members described in Figures 70-74B) can be specifically reinforced or otherwise designed to accommodate a piercing anchor. An adhesive or other material that promotes ingrowth can be applied to the member or delivered separately. Stents with protruding elements capable of engaging the aortic wall (such as those described in International Patent Application Publication No. PCT / US2021 / 024020, entitled "EXPANDABLE DEVICES," filed March 24, 2020, which is incorporated by reference in its entirety into this specification) can also be used at the ends of the base member to improve engagement and permanent fixation with the vessel wall.

[0227] VIII. SELECTED ADDITIONAL EMBODIMENTS OF AORTIC REPAIR DEVICES INCLUDING SPIRAL STENTS Figures 75A-81B illustrate additional embodiments of an aortic repair device including a spiral stent. The illustrated aortic repair devices can include certain features that are at least generally similar in structure and function to (or identical in structure and function to) corresponding features of the aortic repair devices described in detail above with reference to each other and / or Figures 3A-74B, and can operate in a generally similar or identical manner to each other and / or the aortic repair devices described with reference to Figures 3A-74B. Similarly, any of the stents or other features described in detail with reference to Figures 75A-81B can be incorporated into the aortic repair devices of Figures 3A-74B.

[0228] 75A and 75B are side and enlarged isometric side views, respectively, of an aortic repair device 7500 in accordance with an embodiment of the present technology. Referring together to FIGS. 75A and 75B, the aortic repair device 7500 can have a generally tubular shape extending along a longitudinal axis L (FIG. 75A), including a proximal end portion 7581 and a distal end portion 7583, and defining a lumen 7584. In the illustrated embodiment, the aortic repair device 7500 includes a graft material 7580 coupled to a stent 7582. In some embodiments, the graft material 7580 can include at least one pleat 7585 (e.g., a ridge) that extends in a spiral or other pattern at least partially between the proximal end portion 7581 and the distal end portion 7583. In some aspects of the present technology, the pleats 7585 can provide increased flexibility and / or strength for the aortic repair device 7500 along its length.

[0229] 75C is an isometric side view of a stent 7582 in accordance with an embodiment of the present technology. In the illustrated embodiment, the stent 7582 includes a single, integral member that spirals along and around the longitudinal axis L (FIG. 75A). Additionally, the stent 7582 includes a Z-shaped or V-shaped pattern along its length. The stent 7582 can be referred to as a "Z-stent," a "spiral stent," and / or a "Z-spiral stent," etc. In some embodiments, the stent 7582 can include features to enhance radiopacity (e.g., a platinum core and / or radiopaque markers attached thereto, etc.).

[0230] FIG. 75D is a side view of the aortic repair device 7500 of FIGS. 75A-C implanted in the aorta, in accordance with an embodiment of the present technology. In the illustrated embodiment, a proximal end portion 7581 of the aortic repair device 7500 is implanted in the proximal aorta (e.g., ascending aorta, aortic root) and a distal end portion 7583 is implanted in the aortic arch and / or descending thoracic aorta. Thus, the aortic repair device 7500 can route blood flow through the lumen 7584 (FIG. 75B) and through the diseased portion of the aorta (e.g., ascending aortic aneurysm, etc.). The aortic upper bifurcation arteries (e.g., brachiocephalic artery, left common carotid artery, and left subclavian artery) can be perfused via retrograde flow, other implants (not shown), and / or surgical bypass. For example, the aortic repair device 7500 can be fenestrated at appropriate locations and then one or more bifurcation perfusion members can be fluidly connected to the fenestration. In some embodiments, the spiral orientation of the stent 7582 and graft material 7580 can mimic chiral blood flow through the aorta. In some aspects of the present technology, the spiral shape of the stent 7582 provides radial, circumferential (e.g., twisting), and longitudinal support of the graft material 7580, as well as flexibility within the aorta during motion caused by the cardiac cycle (e.g., as opposed to a separate ring stent that may rely on the graft material for longitudinal and circumferential flexibility).

[0231] 75A-75D together, in some embodiments, the graft material 7580 and the stent 7582 can be coextensive (e.g., as shown in FIG. 75A), while in other embodiments, the stent 7582 can extend distally farther than the graft material 7580 (e.g., as shown in FIG. 75D), or vice versa. Additionally, the graft material 7580 can be fixedly attached to the stent material 7582 during manufacture and prior to delivery to the aorta, or can be separate from the stent material 7582 such that the graft material 7580 and the stent 7582 can be delivered separately to the aorta.

[0232] 76A-C are side views of an aortic repair device 7600 during different stages of implantation within the aorta, in accordance with an embodiment of the present technology. Referring together to FIGS. 76A-C, aortic repair device 7600 includes graft material 7680 and Z-stent 7682 configured to be positioned within and expand relative to graft material 7680.

[0233] 76A, the graft material 7680 can be delivered first (before the Z-stent 7682) to the proximal aorta (e.g., the ascending aorta). In the illustrated embodiment, the graft material 7680 is implanted adjacent to a diseased portion of the aorta (e.g., dissection, etc.). In some embodiments, the aortic repair device 7600 includes an anchor 7688 attached to a proximal end portion 7681 of the graft material 7680. The anchor 7688 can include a metallic framing (e.g., an expandable stent) and can (i) secure the graft material 7680 within the aorta, (ii) seal the graft material 7680 within the aorta, and / or (iii) at least temporarily maintain patency of the lumen 7684 of the graft material 7680.

[0234] 76B, a Z-stent 7682 can be advanced into the lumen 7684 of the graft material 7680 and at least partially expanded therein. When expanded, the Z-stent 7682 can exert a radially outward force on the graft material 7680 such that the graft material 7680 seals with the wall of the aorta and diverts blood flow through the lumen 7684 past the diseased portion of the aorta. In some embodiments, the graft material 7680 can be secured to anchors 7688 and / or other anchoring features attached to the graft material 7680.

[0235] In some embodiments, the total length of the Z-stent 7682 can be modified to change the pitch of the spiral shape to change the radial outward force provided by the Z-stent 7682. For example, increasing the length of the Z-stent 7682 can decrease the radial outward force exerted by the Z-stent 7682, while decreasing the length of the Z-stent 7682 can increase the radial outward force exerted by the Z-stent 7682. FIG. 76C, for example, illustrates a Z-stent 7682 having a smaller total length and positioned entirely within the lumen 7684 of the graft material 7680, providing a greater radial outward force than the arrangement of the Z-stent 7682 shown in FIG. The length of the Z-stent 7682 can be determined and changed intraoperatively using images of the procedure until the desired radial force is achieved.

[0236] 77A and 77B are side views of an aortic repair device 7700 during different stages of implantation within the aorta in accordance with an embodiment of the present technology. Referring together to FIGS. 77A and 77B, the aortic repair device 7700 includes a graft material 7780 and a Z-stent 7782 configured to be positioned within and / or around the graft material 7780. Referring to FIG. 77A, the Z-stent 7782 can be delivered first (before the graft material 7780) to the proximal aorta (e.g., the ascending aorta and / or aortic arch). In the illustrated embodiment, the Z-stent 7782 is implanted adjacent to a diseased portion of the aorta (e.g., dissection, etc.). Next, as shown in FIG. 77B, graft material 7780 can be advanced and coupled to at least a portion (e.g., a targeted anchor location) of Z-stent 7782 (e.g., a portion adjacent to the diseased portion of the aorta). The graft material 7780 can include anchoring features (not shown) for interlocking with the Z-stent 7782. After deployment, the graft material 7780 seals with the wall of the aorta and diverts blood flow through the aortic repair device 7700 past the diseased portion of the aorta.

[0237] 78A and 78B are sid...

Claims

1. 1. An aortic repair device comprising: a main body having a first end portion and a second end portion, the main body including a frame coupled to a cover defining a fluid conduit, the first end portion of the main body defining a first fluid opening; a septum extending through the main body from the second end portion of the main body toward the first end portion of the main body, the septum dividing the fluid conduit into a primary lumen having a first cross-sectional area and a secondary lumen having a second cross-sectional area smaller than the first cross-sectional area, the second end portion of the main body defining a second fluid opening for the primary lumen; a leg extending from the second end portion of the main body, the leg defining a leg lumen fluidly connected to the secondary lumen, the leg having an end portion defining a third fluid opening for the secondary lumen; 16. An aortic repair device comprising:

2. the main body portion is configured to be implanted within the ascending portion of the thoracic aorta; the covering includes a graft material coupled to a stent; The aortic repair device further includes a plurality of secondary lumen stents positioned in the secondary lumen; The secondary lumen extends along an axis, the secondary lumen stent is configured to expand to an expanded state; 10. The aortic repair device of claim 1, wherein at least one of the secondary lumen stents has a generally D-shape or an arched D-shape about the axis in the expanded state.

3. the main body portion is configured to be implanted within a descending portion of the thoracic aorta; the covering includes a graft material coupled to a stent; The aortic repair device further includes a plurality of secondary lumen stents positioned in the secondary lumen; The secondary lumen extends along an axis, the secondary lumen stent is configured to expand to an expanded state; 10. The aortic repair device of claim 1, wherein at least one of the secondary lumen stents has a generally D-shape or an arched D-shape about the axis in the expanded state.

4. 10. The aortic repair device of claim 1, wherein the septum extends from the second end portion of the main body and terminates a predetermined distance from the first end portion of the main body.

5. 10. The aortic repair device of claim 1, wherein the septum extends entirely from the second end portion of the main body to the first end portion of the main body.

6. the frame of the main body portion includes a plurality of stents; the covering includes a graft material coupled to the stent; The aortic repair device of claim 1 , further comprising a stent structure positioned within the secondary lumen.

7. 7. The aortic repair device of claim 6, wherein the stent structure is a tubular stent.

8. The aortic repair device of claim 6 , wherein the stent structure comprises a multiple secondary lumen stent.

9. 9. The aortic repair device of claim 8, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has a generally circular shape about the axis in the expanded state.

10. 9. The aortic repair device of claim 8, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has a generally D-shape about the axis in the expanded state.

11. 9. The aortic repair device of claim 8, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has an arched, D-shape about the axis in the expanded state.

12. The secondary lumen extends along an axis, and the secondary lumen stent is configured to expand to an expanded state, wherein in the expanded state: At least one of the secondary lumen stents has a first curved portion extending along the main body portion within the secondary lumen and a second curved portion extending along the septum within the secondary lumen; the first curved portion has a first radius of curvature; 9. The aortic repair device of claim 8, wherein the second curved portion has a second radius of curvature different than the first radius of curvature.

13. The aortic repair device of claim 12 , wherein the first radius of curvature is smaller than the second radius of curvature.

14. 9. The aortic repair device of claim 8, wherein the secondary lumen stent extends only partially around the secondary lumen.

15. the main body portion extends along an axis and has a first side portion and a second side portion, the first side portion proximate the secondary lumen and the second side portion proximate the primary lumen; 10. The aortic repair device of claim 1, wherein the frame includes a plurality of stents, the stents each having an amplitude along the axis, the amplitude of at least one of the stents decreasing in a direction from the first side portion to the second side portion.

16. the main body portion extends along an axis and has a first side portion and a second side portion, the first side portion proximate the secondary lumen and the second side portion proximate the primary lumen; 10. The aortic repair device of claim 1, further comprising a tension member positioned at the second side portion and configured to tension the second side portion to have a curved shape.

17. 17. The aortic repair device of claim 16, wherein the frame of the main body comprises a plurality of stents, the covering comprises a graft material coupled to the stents, and the tension members comprise a plurality of elastic fibers secured between corresponding ones of the stents.

18. 10. The aortic repair device of claim 1, wherein the main body portion extends along a first axis and the legs extend along a second axis that is non-parallel to the first axis.

19. 10. The aortic repair device of claim 1, wherein the main body portion has a diameter of between about 26-54 millimeters and the legs have a diameter of between about 10-22 millimeters.

20. 2. The aortic repair device of claim 1, wherein the main body portion is configured to be positioned within an ascending portion of the thoracic aorta, the first fluid opening is configured to receive blood flow from the ascending portion of the thoracic aorta and the second fluid opening is configured to discharge the blood flow into the thoracic aorta, and at least a portion of the leg portion is configured to be positioned within a bifurcation vessel branching off from the thoracic aorta.

21. 2. The aortic repair device of claim 1, wherein the main body portion is configured to be positioned within a descending portion of the thoracic aorta, the second fluid opening is configured to receive blood flow from the thoracic aorta and the first fluid opening is configured to discharge the blood flow into the descending portion of the thoracic aorta, and at least a portion of the leg portion is configured to be positioned within a bifurcation vessel branching off from the thoracic aorta.

22. 1. A method of repairing a thoracic aorta, the method comprising: endovascularly delivering an aortic repair device to a target site within the thoracic aorta; positioning a main body of the aortic repair device such that an exterior surface of the main body is in sealing contact with a wall of the thoracic aorta, a first fluid opening of the main body being positioned to receive blood flow from the thoracic aorta and a second fluid opening of the main body being positioned to eject a first portion of the blood flow into the thoracic aorta; the aortic repair device includes a septum extending at least partially between the first fluid opening and the second fluid opening of the main body portion, the septum dividing the main body portion into a primary lumen and a secondary lumen; the first fluid opening of the main body portion fluidly coupled to the primary lumen to receive the first portion of the blood flow therethrough; positioning at least a portion of a leg of the aortic repair device into a bifurcation vessel branching from the thoracic aorta, a third fluid opening of the leg being positioned in the bifurcation vessel and adapted to eject a second portion of the blood flow into the bifurcation vessel; the third fluid opening is fluidly coupled to the secondary lumen and receives the second portion of the blood flow therethrough; A method comprising:

23. 23. The method of claim 22, wherein the main body portion has a length extending between the first fluid opening and the second fluid opening, and positioning the main body portion of the aortic repair device comprises positioning the main body portion in sealing contact with the wall of the thoracic aorta along substantially an entire length of the main body portion.

24. 23. The method of claim 22, wherein the wall of the thoracic aorta is a wall of an ascending portion of the thoracic aorta, the leg portion extending from the main body portion proximate the second fluid opening, and the septum extending from the second fluid opening at least partially toward the first fluid opening.

25. 25. The method of claim 24, wherein the bifurcation vessel is the brachiocephalic artery.

26. 25. The method of claim 24, wherein the bifurcation vessel is the left subclavian artery.

27. 25. The method of claim 24, wherein the bifurcation vessel is the left common carotid artery.

28. 23. The method of claim 22, wherein the wall of the thoracic aorta is a wall of a descending portion of the thoracic aorta, the leg portion extending from the main body portion proximate the first fluid opening, and the septum extending from the first fluid opening at least partially toward the second fluid opening.

29. 30. The method of claim 28, wherein the bifurcation vessel is the left subclavian artery.

30. 30. The method of claim 28, wherein the bifurcation vessel is the brachiocephalic artery.

31. 30. The method of claim 28, wherein the bifurcation vessel is the left common carotid artery.

32. 23. The method of claim 22, further comprising expanding a stent structure at least partially into the secondary lumen.

33. 33. The method of claim 32, wherein expanding the stent structure comprises placing a tubular stent at least partially within the secondary lumen.

34. 33. The method of claim 32, wherein expanding the stent structure comprises allowing a plurality of stents in the secondary lumen to self-expand.

35. 35. The method of claim 34, wherein the stent has a generally D-shape or an arched D-shape, respectively.

36. 33. The method of claim 32, further comprising maintaining a cross-sectional area of ​​the secondary lumen with the stent structure.

37. The method comprises: positioning a portion of a spanning member of the aortic repair device within a portion of the primary lumen of the main body portion; maintaining a cross-sectional area of ​​the secondary lumen with the stent structure when the portion of the spanning member is positioned within the secondary lumen; 33. The method of claim 32, further comprising:

38. 38. The method of claim 37, wherein the wall of the thoracic aorta is a wall of an ascending portion of the thoracic aorta, the leg extending from the main body portion proximate the second fluid opening, and wherein positioning the portion of the spanning member within the portion of the primary lumen of the main body portion comprises inserting the portion of the spanning member through the second fluid opening.

39. 38. The method of claim 37, wherein the wall of the thoracic aorta is a wall of a descending portion of the thoracic aorta, the legs extending from the main body portion proximate the first fluid opening, and wherein positioning the portion of the spanning member within the portion of the primary lumen of the main body portion comprises inserting the portion of the spanning member through the first fluid opening.

40. 23. The method of claim 22, wherein positioning the main body of the aortic repair device comprises positioning the main body adjacent an aortic aneurysm.

41. 23. The method of claim 22, wherein positioning the main body of the aortic repair device comprises positioning the main body adjacent an aortic dissection.

42. 1. An aortic repair device comprising: A base member is included. The base member is a main body having a first end portion and a second end portion, the main body including a frame coupled to a cover defining a fluid conduit, the first end portion of the main body defining a first body fluid opening; a septum extending through the main body from the second end portion of the main body toward the first end portion of the main body, the septum dividing the fluid conduit into a primary lumen having a first cross-sectional area and a secondary lumen having a second cross-sectional area smaller than the first cross-sectional area, the second end portion of the main body defining a second body fluid opening for the primary lumen; a leg extending from the second end portion of the main body, the leg defining a leg lumen fluidly connected to the secondary lumen, the leg having an end portion defining a leg fluid opening for the secondary lumen; Including, The aortic repair device further comprises: a spanning member having a first end portion defining a first spanning fluid opening and a second end portion defining a second spanning fluid opening, the spanning member defining a spanning lumen extending between the first spanning fluid opening and the second spanning fluid opening, the first end portion configured to (a) extend through the second body portion fluid opening, (b) be secured within the primary lumen, and (c) sealingly engage the septum and the main body portion within the primary lumen to define a continuous flow path through the primary lumen, the first spanning fluid opening, the spanning lumen, and the second spanning fluid opening.

16. An aortic repair device comprising:

43. 43. The aortic repair device of claim 42, wherein the base member comprises a first stent graft and the spanning member comprises a second stent graft.

44. 43. The aortic repair device of claim 42, wherein the frame of the main body portion comprises a plurality of stents, the covering comprises a graft material coupled to the stents, and the base member further comprises a stent structure positioned in the secondary lumen to maintain the second cross-sectional area when the first end portion of the spanning member is secured in the primary lumen.

45. 45. The aortic repair device of claim 44, wherein the stent structure is a tubular stent.

46. 45. The aortic repair device of claim 44, wherein the stent structure comprises a multiple secondary lumen stent.

47. 47. The aortic repair device of claim 46, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has a generally circular shape about the axis in the expanded state.

48. 47. The aortic repair device of claim 46, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has a generally D-shape about the axis in the expanded state.

49. 47. The aortic repair device of claim 46, wherein the secondary lumens extend along an axis, the secondary lumen stents are configured to expand to an expanded state, and at least one of the secondary lumen stents has a generally arcuate, D-shape about the axis in the expanded state.

50. 43. The aortic repair device of claim 42, wherein the spanning member has a scalloped pattern at the first end portion.

51. 43. The aortic repair device of claim 42, wherein the spanning member has an intermediate portion between the first end portion and the second end portion, the first end portion having a first diameter and the intermediate portion having a second diameter smaller than the first diameter.

52. 43. The aortic repair device of claim 42, wherein the spanning member extends along an axis, the spanning member having an intermediate portion between the first end portion and the second end portion, the spanning member comprising graft material coupled to a plurality of stents, the stents extending circumferentially about the axis and having a periodic shape about the axis, a first one of the stents at the first end portion having a first amplitude and a second one of the stents at the intermediate portion having a second amplitude greater than the first amplitude.

53. 43. The aortic repair device of claim 42, wherein the spanning member extends along an axis, the spanning member having an intermediate portion between the first end portion and the second end portion, the spanning member comprising graft material coupled to a plurality of stents, the stents extending circumferentially about the axis and having a periodic shape about the axis, a first one of the stents at the first end portion having a first frequency and a second one of the stents at the intermediate portion having a second frequency less than the first frequency.

54. 43. The aortic repair device of claim 42, wherein the spanning member extends along an axis, the spanning member having an intermediate portion between the first end portion and the second end portion, the spanning member comprising graft material coupled to a plurality of stents, the stents extending circumferentially about the axis and having a periodic shape about the axis, a first one of the stents at the first end portion having a first frequency and a first amplitude and a second one of the stents at the intermediate portion having a second frequency and a second amplitude, the first frequency being greater than the second frequency and the first amplitude being less than the second amplitude.

55. the main body portion is configured to be positioned within the ascending portion of the thoracic aorta, and the first body portion fluid opening is adapted to receive blood flow from the ascending portion of the thoracic aorta; at least a portion of the leg is configured to be positioned within a branch vessel branching from the thoracic aorta, the leg being adapted to (a) receive a first portion of the blood flow from the first body fluid opening through the secondary lumen, and (b) route the first portion of the blood flow for discharge through the leg fluid opening into the branch vessel; 43. The aortic repair device of claim 42, wherein the spanning member is configured to be positioned within the thoracic aorta to span an arched portion of the thoracic aorta, (a) the first spanning inlet portion is adapted to receive a second portion of the blood flow from the first body portion fluid opening through the primary lumen, and (b) the spanning lumen is adapted to route the second portion of the blood flow to the second spanning outlet portion for discharge into the thoracic aorta through the second spanning fluid opening.

56. the spanning member is configured to be positioned within the thoracic aorta to span an arch of the thoracic aorta, (a) the second spanning fluid opening is adapted to receive blood flow from the thoracic aorta, and (b) the spanning lumen is adapted to route the blood flow to the first spanning fluid opening; the main body portion is configured to be positioned within the descending portion of the thoracic aorta, (a) the second body portion fluid opening is adapted to receive the blood flow from the first spanning fluid opening, and (b) the primary lumen is adapted to route the blood flow to the first body portion fluid opening for discharge into the descending thoracic aorta; 43. The aortic repair device of claim 42, wherein at least a portion of the leg is configured to be positioned within a bifurcation vessel branching from the thoracic aorta.

57. at least a portion of the leg is configured to be positioned within a bifurcation vessel branching from the thoracic aorta; the first body fluid opening of the main body portion is further configured to receive retrograde blood flow from the descending thoracic aorta and / or a portion of the blood flow from the primary lumen; 57. The aortic repair device of claim 56, wherein the secondary lumen is configured to route the retrograde blood flow and / or the portion of the blood flow from the primary lumen to the leg for discharge through the leg fluid opening into the bifurcation vessel.

58. 1. A method of repairing a thoracic aorta, the method comprising: endovascularly delivering an aortic repair device to a target site within the thoracic aorta; positioning a main body of a base member of the aortic repair device such that an exterior surface of the main body is in sealing contact with a wall of the thoracic aorta, the main body including a first body fluid opening, a second body fluid opening, and a septum, the septum extending from the second body fluid opening at least partially toward the first body fluid opening, the septum dividing the main body into a primary lumen and a secondary lumen; the second body fluid opening of the main body fluidly connected to the primary lumen; positioning at least a portion of a leg of the base member within a branch vessel branching from the thoracic aorta such that a leg fluid opening of the leg is positioned within the branch vessel; the leg fluid opening is fluidly connected to the secondary lumen; the legs extending from the main body adjacent the second body fluid opening; positioning a spanning member within the thoracic aorta, the spanning member having a first end portion defining a first spanning fluid opening and a second end portion defining a second spanning fluid opening, the spanning member defining a spanning lumen extending between the first spanning fluid opening and the second spanning fluid opening; positioning the first end portion of the spanning member through the second body fluid opening and into the primary lumen; sealingly engaging the first end portion of the spanning member with the septum and the main body portion within the primary lumen to define a continuous flow path through the spanning lumen and the primary lumen. A method comprising:

59. 59. The method of claim 58, wherein the wall of the thoracic aorta is a wall of an ascending portion of the thoracic aorta, and positioning the main body portion of the base member includes positioning the first body portion fluid opening to accept the blood flow from the ascending portion of the thoracic aorta such that: (a) the primary lumen accepts a first portion of the blood flow and routes the first portion of the blood flow toward the second body portion fluid opening; and (b) the secondary lumen accepts a second portion of the blood flow and routes the second portion of the blood flow to the leg fluid opening.

60. 60. The method of claim 59, wherein positioning the first end portion of the spanning member within the primary lumen comprises positioning the spanning member to (a) receive the first portion of the blood flow from the secondary lumen of the main body portion, and (b) expel the first portion of the blood flow through the second spanning fluid opening and into the thoracic aorta.

61. 61. The method of claim 60, wherein positioning the spanning member within the thoracic aorta comprises positioning the spanning member to span an arched portion of the thoracic aorta, and positioning the first end portion of the spanning member within the primary lumen comprises positioning the spanning member to eject the first portion of the blood flow into a descending portion of the thoracic aorta.

62. 59. The method of claim 58, wherein the wall of the thoracic aorta is a wall of a descending portion of the thoracic aorta, and positioning the spanning member within the thoracic aorta comprises positioning the spanning member such that (a) the second spanning fluid opening accepts blood flow from the thoracic aorta, and (b) the spanning lumen routes the blood flow through the first spanning fluid opening to the primary lumen of the main body portion.

63. 63. The method of claim 62, wherein positioning the main body portion of the base member includes positioning the first body portion fluid opening to discharge the blood flow into the descending portion of the thoracic aorta.

64. 64. The method of claim 63, wherein positioning the main body of the base member comprises: (a) positioning the first body fluid opening to receive retrograde blood flow from the descending portion of the thoracic aorta; and (b) positioning the secondary lumen to route the retrograde blood flow to the leg for ejection through the leg fluid opening into the bifurcation vessel.

65. 64. The method of claim 63, wherein the septum extends from the second body fluid opening of the main body and terminates a predetermined distance from the first body fluid opening of the main body, and positioning the main body of the base member includes positioning the secondary lumen to (a) receive a portion of the blood flow along the distance, and (b) route the portion of the blood flow to the leg for ejection through the leg fluid opening into the branch vessel.

66. 63. The method of claim 62, wherein positioning the spanning member within the thoracic aorta comprises positioning the spanning member across an arched portion of the thoracic aorta such that the second spanning fluid opening receives the blood flow from an ascending portion of the thoracic aorta.

67. 59. The method of claim 58, wherein the main body portion has a length extending between the first body portion fluid opening and the second body portion fluid opening, and positioning the main body portion on the base member includes positioning the main body portion in sealing contact with the wall of the thoracic aorta along substantially an entire length of the main body portion.

68. 59. The method of claim 58, wherein positioning the spanning member within the thoracic aorta comprises positioning the spanning member across an arched portion of the thoracic aorta.

69. 59. The method of claim 58, further comprising expanding a stent structure at least partially into the secondary lumen to inhibit compression of the septum by the spanning member and to maintain a cross-sectional area of ​​the secondary lumen.

70. 70. The method of claim 69, wherein expanding the stent structure comprises placing a tubular stent at least partially within the secondary lumen.

71. 70. The method of claim 69, wherein expanding the stent structure comprises allowing a plurality of stents in the secondary lumen to self-expand.

72. 72. The method of claim 71, wherein the stent has a generally D-shape or a generally arcuate D-shape, respectively.

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