Method, system and device for individualized supplemental oxygen therapy for premature infants

By measuring pulmonary resilience and ANS activity through heart rate analysis, the method dynamically adjusts oxygen saturation for premature infants, addressing the trade-off between excessive oxygen exposure and mortality, thereby reducing BPD and other complications.

JP2025522423APending Publication Date: 2025-07-15MEDICAL PREDICTIVE SCIENCE CORP
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Patent Information

Application Number
JP2024573431
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-04-28
Filing Date
2023-06-06
Publication Date
2025-07-15

AI Technical Summary

Technical Problem

Current clinical guidelines for oxygen saturation targeting in premature infants lead to excessive oxygen exposure, increasing the risk of bronchopulmonary dysplasia (BPD) and other complications, while attempts to minimize oxygen can increase mortality, highlighting the need for individualized control of oxygen saturation based on the infant's physiological state.

Method used

Measuring pulmonary resilience and autonomic nervous system (ANS) activity through heart rate signal analysis to dynamically adjust the oxygen saturation target range for premature infants, using heart rate variability (HRV) and heart rate characteristics (HRC) to optimize oxygen delivery and minimize toxicity.

Benefits of technology

Individualized oxygen saturation targeting reduces the risk of bronchopulmonary dysplasia and other complications by promoting environmental adaptation, while minimizing mortality and long-term health impacts.

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Abstract

Examples of methods, systems, and / or devices assist in the dynamic optimization of an oxygen saturation target range for a premature infant in a manner individualized to the physiological state of the premature infant. In an exemplary embodiment, the oxygen saturation is dynamically targeted by monitoring the heart rate and / or determining a pulmonary resilience measurement (PRM) of the premature infant and adjusting the oxygen saturation target range for the premature infant. In various embodiments, the heart rate variability measurement and / or the PRM are evaluated against a predetermined threshold, and if the heart rate variability measurement and / or the PRM meet or exceed the predetermined threshold, the oxygen saturation target range is adjusted. Embodiments of the present disclosure can optionally further readjust the oxygen saturation target range based on an alert indicating the oxygen saturation target range and / or at regular intervals based on the heart rate variability measurement and / or the PRM.
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Citation Information

Patent Citations

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