Secondary packaging configured to hold at least one device for administering a medication, a method for attaching at least one device for administering a medication to the secondary packaging, and a method for treating a patient

Abstract

The secondary packaging configured to hold a device for administering a medication may include a body including at least one clip attached to an inner surface thereof. The at least one clip may be configured to surround at least a portion of the device, the clip configured to prevent inadvertent removal or movement of the device relative to the body. The secondary packaging may also include a cap pivotally attached to the body. The cap and body may combine to form a cavity for holding the device when the cap is in a closed position relative to the body.

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Patent Application No. 63 / 370,045, entitled "PACKAGING CONFIGURED TO HOLD A DEVICE FOR ADMINISTERING MEDICINE OR A DRUG," filed August 1, 2022, which is incorporated by reference in its entirety.

[0002] The disclosed technology generally relates to secondary packaging configured to hold a device designed to administer contents, such as, but not limited to, a medication. More specifically, in one embodiment, the disclosed technology relates to secondary packaging configured to prevent inadvertent actuation of an inhaler and / or to protect the inhaler during storage, transport, and / or non-use. [Background technology]

[0003] Devices for administering or releasing contents, such as one or more medications, are often stored or transported in secondary packaging. The secondary packaging is designed to protect the device(s) in a compact and economical manner. The secondary packaging can be discarded or reused, for example, once the end user or healthcare professional removes the device(s) from the secondary packaging for use.

[0004] Inadvertent actuation within the secondary packaging of the above-mentioned devices and damage to the devices is not uncommon. Inadvertent actuation can waste beneficial contents (e.g., medication) and can also soil the inside and outside of the secondary packaging. Damage to the device(s) can render the device unusable, resulting in the waste of beneficial contents and the waste of raw materials used to form the device. Summary of the Invention

[0005] There is a need to prevent inadvertent activation of the device(s) stored within the secondary packaging. There is also a need for simplified and / or different configurations of secondary packaging that can reliably hold and protect one or more of the above-mentioned devices in a more compact and economical manner. For example, it would be beneficial to create secondary packaging that is not necessarily childproof, but requires or at least benefits from two hands to open. It would also be beneficial to create secondary packaging that is streamlined and convenient to store and transport.

[0006] These and other needs are addressed by the techniques of this disclosure.

[0007] In one aspect, the disclosed technology is directed to a secondary package configured to hold one or more devices for administering a medication. The secondary package can include a body having a base and a sidewall extending upward from the base. The secondary package can also include a cap removably attachable to the body. The cap and body can combine to form a cavity for holding the device when the cap is attached to the body.

[0008] In another aspect, the technology of the present disclosure is directed to the combination of a nasal dose inhaler and a secondary packaging configured to hold one or more of the nasal dose inhalers.

[0009] In yet another aspect, the disclosed technology is directed to a secondary package configured to hold one or more devices for administering a medication. The secondary package can include a body and a cap pivotally attached to the body. The cap and body can combine to form a cavity for holding the device when the cap is attached to the body. The body can include a clip on an inner surface thereof. The clip can be configured to surround at least a portion of the device. The clip can be configured to prevent inadvertent removal or movement of the device relative to the body.

[0010] In yet another aspect, the disclosed technology is directed to a secondary packaging configured to hold a device for administering a medication, which can include a body having at least one clip attached to an inner surface thereof. The at least one clip can be configured to surround at least a portion of the device. The clip can be configured to prevent inadvertent removal or movement of the device relative to the body. The secondary packaging can also include a cap pivotally attached to the body. The cap and body can combine to form a cavity for holding the device when the cap is in a closed position relative to the body.

[0011] In yet another aspect, the disclosed technology is directed to a method of attaching a device for administering a medication to a secondary package, the method may include pivoting a cap of the secondary package relative to a body of the secondary package about a hinge of the secondary package to move the secondary package from a closed configuration to an open configuration to expose a cavity. The method may include placing the device for administering a medication within at least one clip attached to an inner surface of the body of the secondary package. The at least one clip may be configured to encircle at least a portion of the device. The clip may be configured to prevent inadvertent removal or movement of the device relative to the body.

[0012] Optionally, the device is snap-fit into the clip.

[0013] The following detailed description of the technology of the present disclosure will be better understood when read in conjunction with the accompanying drawings, in which like numerals refer to like elements throughout. For the purpose of illustrating the technology of the present disclosure, there are shown in the drawings various exemplary embodiments. It should be understood, however, that the technology of the present disclosure is not limited to the precise arrangements and instrumentalities shown. The drawings are as follows: [Brief explanation of the drawings]

[0014] [Figure 1] FIG. 1 is a perspective view of a secondary package according to an optional aspect of the disclosed technology, showing the secondary package in a first or closed position. [Figure 2] FIG. 2 is a front view of the secondary packaging shown in FIG. 1. [Figure 3] FIG. 2 is a side elevation view of the secondary packaging shown in FIG. 1. [Figure 4] FIG. 2 is a cross-sectional side elevation view of the secondary packaging taken along line AA of FIG. 1. [Figure 4a] FIG. 2 is a perspective view of an optional device configured to be held by the secondary packaging shown in FIG. 1. [Figure 5] FIG. 2 is a top view of the secondary packaging shown in FIG. 1. [Figure 6] 4a is a partially exploded perspective view of the secondary packaging shown in FIG. 1, with the secondary packaging in a second or open position and an optional device for administering a medication according to FIG. 4a shown therein; FIG. [Figure 7] 4b is another partially exploded perspective view of the secondary packaging shown in FIG. 1, with the secondary packaging in an open position and the device of FIG. 4a shown therein; FIG. [Figure 8] 4b is yet another partially exploded perspective view of the secondary packaging shown in FIG. 1, with the secondary packaging in an open position and the device of FIG. 4a shown therein; FIG. [Figure 9] FIG. 10 is a perspective view of a secondary package according to another optional aspect of the disclosed technology, the secondary package being shown in a first or closed position. [Figure 10] FIG. 10 is a top view of the secondary packaging shown in FIG. [Figure 11] FIG. 10 is a front view of the secondary packaging shown in FIG. [Figure 12] FIG. 10 is a right side view of the secondary packaging shown in FIG. [Figure 13] FIG. 10 is a top view of the secondary packaging shown in FIG. 9, with the secondary packaging shown in a second or open position and with a device for administering medication shown therein. [Figure 14]FIG. 10 is another perspective view of the secondary packaging shown in FIG. 9, with the secondary packaging shown in an open position and with a device therein. [Figure 15] FIG. 10 is another perspective view of the secondary packaging shown in FIG. 9 with the device removed for clarity. [Figure 16] FIG. 10 is a perspective view of a secondary package according to a modified version of the secondary package shown in FIG. 9, with the secondary package shown in a closed position. [Figure 17] FIG. 17 is a top view of the secondary packaging shown in FIG. 16. [Figure 18] FIG. 17 is a front view of the secondary packaging shown in FIG. 16. [Figure 19] FIG. 17 is a right side view of the secondary packaging shown in FIG. 16. [Figure 20] FIG. 17 is a top view of the secondary packaging shown in FIG. 16, with the secondary packaging shown in a second or open position and with two devices for administering medication shown therein. DETAILED DESCRIPTION OF THE INVENTION

[0015] While systems, devices, and methods are described herein by way of examples and embodiments, those skilled in the art will recognize that the technology of this disclosure is not limited to the described embodiments or drawings. On the contrary, the technology of this disclosure encompasses all modifications, equivalents, and alternatives falling within the spirit and scope of the appended claims. Features of any one embodiment disclosed herein may be omitted or incorporated in another embodiment.

[0016] Any headings used herein are for organizational purposes only and are not meant to limit the scope of the specification or claims. As used herein, the word "may" is used in its permissive sense (i.e., having the possibility) rather than its required sense (i.e., meaning must). Unless specifically stated herein, the terms "a," "an," and "the" should not be read to be limited to one element but instead to mean "at least one." The term includes the above words, derivatives thereof, and words of similar import.

[0017] As used herein, "and / or" means either or both of the items separated by such term. For example, the phrase "A and / or B" would mean A alone, B alone, or both A and B.

[0018] As used herein, "generally" means "in the general manner" associated with the modified term, as understood by one of ordinary skill in the art.

[0019] Directional terms used herein, such as, but not limited to, top, bottom, left, right, upper, lower, front, rear, and derivatives thereof, refer to the orientation of the elements as shown in the drawings and are not limited to the claims unless expressly recited herein.

[0020] In one optional embodiment, the secondary packaging described herein is not moisture-tight.

[0021] In another optional embodiment, the secondary packaging described herein is moisture-tight and resealable. Generally, as used herein, the term "moisture-tight" is defined as having a moisture ingress of less than 1500 μg of water, in another embodiment less than 500 μg of water, in a further embodiment less than 300 μg of water, and in yet another embodiment less than 150 μg of water (after 3 days), as determined by the following test method: (a) placing plus or minus 0.25 grams of molecular sieve into a container and recording the weight, (b) completely closing the container, (c) placing the sealed container in an environmental chamber at 80% relative humidity and 72°F, (d) after 1 day, weighing the container containing the molecular sieve, (e) after 4 days, weighing the container containing the molecular sieve, and (f) calculating the moisture ingress of the container in micrograms of water by subtracting the first day's sample from the fourth day's sample. A preferred rate of moisture ingress into a moisture-tight sealed container manufactured according to one embodiment of the disclosed concepts is in the range of about 200-300 μg / day or less of water. Thus, a "moisture-tight" seal is a sealing engagement that, alone or in combination with additional sealing engagements, serves to make the container "moisture-tight" according to the above definition.

[0022] As used herein, the term "resealable" means that the lid of a container can be opened, reopened, closed, or resealed multiple times (e.g., 10 or more times) and still retain its moisture-tight properties.

[0023] As used herein, the term "secondary" in the phrase "secondary packaging" means that the packaging does not directly contain or hold contents that are consumed by a user, but instead holds packaging that directly contains or holds contents that are consumed by a user.

[0024] Referring now in detail to the various drawings, in which like reference numerals refer to like parts throughout, Figures 1-8 show a combination of secondary packaging, generally designated 10, and at least one device, generally designated 12. Each device 12 can be configured to store, release, and / or administer contents therein, such as, but not limited to, a medication. Secondary packaging 10 can be configured to hold or contain one or more of devices 12 therein and to prevent inadvertent actuation of device 12, for example, via axial compression.

[0025] Optionally, device 12 is an inhaler, such as, but not limited to, a nasal inhaler, a metered dose inhaler (MDI), a dry powder inhaler (DPI), and a soft mist inhaler (SMI). The inhaler can be a single dose (UDS) or a two dose (BDS) inhaler. Device 12 can optionally include spring 13 (see FIG. 4a) to facilitate movement (e.g., extension and / or retraction) of device 12 from an actuated position, in which at least a portion of the contents of device 12 are released or dispensed, to an inactuated position, in which the contents of device 12 are prevented from exiting. However, device 12 is not limited to an inhaler, as device 12 can be any structure configured to store, release, and / or dispense contents held therein, such as an eye dropper or pepper spray.

[0026] Optionally, the active pharmaceutical ingredient (API) stored within and / or delivered by device 12 may be one or more of naloxone, ketamine, midazolam, fentanyl, lorazepam, glucagon, nalmefene, epinephrine, apomorphine, cetrorelix, loxapine, eletriptan, ketorolac, and / or olanzapine.

[0027] Device 12 may optionally be employed to store and / or deliver, for example, insulin and / or epinephrine and / or another medication to treat or alleviate the symptoms of diabetes or asthma.

[0028] In one optional embodiment, device 12 can be pre-filled and can provide a dosage form of medication. Specifically, device 12 can be a dispersion device that delivers a dosage form of medication, such as a metered aerosol or spray device. Device 12 can be pre-filled with a finished dosage form of medication(s). Embodiments include devices such as those referenced in 68 Federal Register Nos. 36,675, 36,676, and 36,680 (June 18, 2003). Exemplary embodiments include intranasal aerosol and spray devices.

[0029] The secondary packaging 10 is particularly well suited for use with a device 12 used to administer a powdered medication, such as an intranasal delivery powder. The medication can be any that can be delivered by a dispersion device. For example, as referenced in 21 C.FR §314.3, the medication(s) can be associated with one or more other ingredients.

[0030] In an optional embodiment, the medication stored within device 12 is a powdered medication, such as glucagon. Device 12 can be configured to deliver a simple, single-use nasal powder of glucagon or another medication. This offers a significant advantage over complex systems that involve mixing a liquid and a powder together and then injecting the solution. Patient use of device 12 has been metered to normalize blood glucose levels within 30 minutes of taking the powdered glucagon.

[0031] In one optional embodiment, the nasal powder can be administered by a single-use, one-step ejection device. The tip of the device 12 can be inserted into one nostril, and the dose can be delivered by simply depressing an actuator connected to a piston that ejects the powder into the nostril. Absorption occurs through the nasal mucosa, so no patient intervention is required. A glucagon formulation is provided in the device 12, providing highly effective protection against the survivability of both the glucagon and its delivery device.

[0032] Further details regarding device 12 or similar devices that may be used in accordance with optional aspects of the disclosed techniques are disclosed in US Pat. No. 10,894,133, which is incorporated herein by reference in its entirety.

[0033] The secondary package 10 may include a body 14 having a base 18 and a sidewall 20 extending upwardly from the base 18. The end of the sidewall 20 opposite the base 18 may include a rim 22 (see Figures 6 and 7) that surrounds and / or defines an opening 24 to the cavity 16. Optionally, the opening 24 is oval or circular.

[0034] The secondary packaging 10 may also include a cover or cap 26 that is removably attachable to and / or separable from (e.g., spaced apart from) the body 14. The cap 26 may include a top wall 30 and a side wall 31 extending downwardly therefrom. The cap 26 may include an annular skirt 28 extending downwardly (directly or indirectly) from the side wall 31 and / or a top portion of the cap 26. In this optional embodiment, the top wall 30 of the cap 26 is at least partially or completely flat. Alternatively, the top wall 30 may be partially or completely arcuate.

[0035] In one embodiment, the cap 26, body 14, and / or other features of the secondary package 10 are optionally made primarily or exclusively from one or more injection-moldable thermoplastic materials, including, for example, polyolefins such as polypropylene (PP) or polyethylene. To make it easier to recycle, it may be beneficial to make the entire secondary package 10 and its components from a single material.

[0036] In this optional embodiment, cap 26 is movable relative to and / or separable from body 14 between a first or closed position (e.g., FIGS. 1-5 ) in which cap 26 and body 14 can optionally form a seal, such as, but not limited to, a watertight seal, and a second or open position (e.g., FIGS. 6-8 ) in which opening 24 in body 14 is exposed. Optionally, at least a portion of skirt 28, or all of skirt 28, is configured to fit within at least a portion of sidewall 20 of body 14 when cap 26 is attached to body 14.

[0037] In the closed position, the cap 26 and the body 14 can combine to form a cavity 16 (see FIG. 4 ) for holding, protecting, and / or enclosing the device 12 when the cap 26 is attached to the body 14. The cavity 16 can be configured to receive the entire device 12.

[0038] In one optional embodiment, the cap 26 is completely separable from the body 14 in the open position, such that the package 10 is formed of two different or separate pieces. In an alternative optional embodiment, a hinge may connect the cap 26 to the body 14. The cap 26 may optionally be resealable to the body 14.

[0039] In this optional embodiment, the body 14 and cap 26 may combine to form a cylinder or bottle, such that the sidewall 20 of the body 14 and the sidewall 31 of the cap 26 may be at least partially arcuate or rounded. However, the disclosed concepts may include or be other shapes, such as a rectangular prism or cube, and thus have a single continuous (e.g., rounded) sidewall.

[0040] While a child-resistant cap or package may be desirable in certain applications, it is not required in all applications. Accordingly, child-resistant and non-child-resistant caps or packages are contemplated. If a child-resistant feature is provided, the child-resistant feature optionally requires the application of two or more unidirectional forces to the cap 26 to remove the cap 26 from the body 14.

[0041] Optionally, at least a portion of body 14, cap 26, and / or secondary packaging 10 are configured to and / or include means for preventing movement of device 12 that would otherwise release or administer the agent when device 12 is in cavity 16 (e.g., when cap 26 is attached to body 14). For example, the inner surface of body 14 may include a ledge 15 (see FIG. 4a) that is configured to contact a portion of device 12 to prevent device 12 from moving from the inactivated position to the activated position when cap 26 is attached to body 14.

[0042] 7, the means for preventing movement of the device 12 that would otherwise result in release or administration of the agent, or the packaging 10, can include at least one or more spaced apart fins or ribs 34 extending inwardly into the cavity 16 from the inner surface of the body 14. In one optional embodiment, each fin 34 can extend inwardly and / or upwardly from the inner surface of the base 18 of the body 14. The top surface of one or more of the fins 34 can form a ledge 15.

[0043] 8, the means for preventing movement of device 12 that would otherwise result in release or administration of the agent, or packaging 10, can include at least one or more spaced apart fins or ribs 36 extending inwardly into cavity 16 from the inner surface of cap 26. In one optional embodiment, each fin 36 can extend inwardly and / or upwardly from the inner surface of the top wall of cap 26.

[0044] Optionally, fins 34, 36 may be positioned on either side of the upper and lower ends of device 12 to help maintain the upper end of device 12 in particular or desired lateral and vertical positions when cap 26 is in the closed position and device 12 is within cavity 16. Each fin 34, 36 may be configured to prevent device 12 from being reconfigured from the unactuated position to the actuated position. Each fin 34, 36 may be of sufficient length and / or width to contact (or at least nearly contact) a portion of device 12 when device 12 is positioned within cavity 16 and cap 26 is in the closed position to inhibit or prevent even slight movement of device 12 from the unactuated position to the actuated position (i.e., prevent the device from being compressed axially).

[0045] 6 and 8, the skirt 28 of the cap 26 may optionally include at least one or more spaced apart projections 40 extending at least slightly radially outward therefrom. Each projection 40 may be positioned closer to the end of the skirt 28 near the side wall 31 of the cap 26 than to the free end of the skirt 28. Optionally, two spaced apart projections 40 may be linearly arranged across the width of the skirt 28.

[0046] In one optional embodiment, the sidewall 20 of the body 14 may include at least one or more spaced apart openings or grooves 42 extending into or through the interior. Each opening 42 may be configured to receive at least a portion of one of the protrusions 40 when the cap 26 is in a closed position relative to the body 14. The combined engagement or disengagement of each protrusion 40 and opening 42 may provide a tactile indication to the user that the package 10 has been closed (e.g., by tactilely or perceptually snapping or clicking) or opened, respectively. Of course, each of the protrusions 40 and openings / grooves 42 may be reversed in location such that each protrusion 40 is positioned relative to the body 14.

[0047] 7, the thickness of the sidewall 20 of the body 14 adjacent the rim 26 of the body 14 and each opening or groove 42 can have a reduced dimension (e.g., in a radial direction) generally designated RD, such that the reduced thickness of each sidewall 20 at these locations allows one of the projections 40 to more easily enter and exit the respective opening or groove 42. Each reduced thickness region can have a lateral width that is the same as or similar to the lateral width of the opening or groove 42 that corresponds to that region.

[0048] 6-8, skirt 28 may optionally include at least one or more spaced apart notches 44. Each notch 44 may be wider at a free end of skirt 28 and narrow or tapered as the notch moves toward the opposite end of skirt 28. Each notch 44 provides flexibility to skirt 28, which may facilitate moving cap 26 from an open position to a closed position and may help prevent or reduce the possibility of undesired warping or flexing of the component.

[0049] 2, cap 26 can include one or at least two opposing cap thumb tabs 46, and body 14 can include one or at least two opposing body thumb tabs 48. In an optional embodiment in which package 10 has an oval configuration when viewed from below or above, cap thumb tabs 46 can be aligned along a major axis, and body thumb tabs 48 can be aligned along a minor axis that is perpendicular to the major axis.

[0050] Optionally, each thumb tab 46, 48 is fixed or immovable relative to its respective side wall 20, 31. Alternatively, each thumb tab 46, 48 may be movable relative to its respective side wall 20, 31. In the latter instance, simultaneous engagement of at least two of the opposing cap thumb tabs 46 or body thumb tabs 48 disengages the protrusion 40 from its respective opening or groove 42.

[0051] One or both of the thumb tabs 46, 48, or a set of the thumb tabs 46, 48, may be configured to be engaged and / or depressed by a user to facilitate separation of the cap 26 from and / or attachment of the cap 26 to the body 14. In particular, lateral inward movement of one or both of the thumb tabs 46, 48, or a set of the thumb tabs 46, 48, such as by a user's finger, may help to facilitate engagement or separation of the protrusion(s) 40 and the opening(s) 42.

[0052] 7 , a ring 50 may optionally extend inward or upward from the inner surface of the base 18 of the body 14. The ring 50 may be configured to receive at least a portion of the device 12 when the device 12 is installed within the body 14. The ring 50 may help prevent inadvertent or undesired movement of the device 12 relative to the body 14 and / or reduce the likelihood of damage to the device 12 inside the secondary packaging 10.

[0053] Optionally, the secondary packaging 10, e.g., the cap 26 and / or its body 14, may include an active polymer component affixed to or integral with the body 14. For example, the active polymer component may be part of the molding process of the body 14 and / or cap 26 such that the end user cannot visually see the active polymer component from the body 14 and / or cap 26.

[0054] In another optional embodiment, the secondary packaging 10 does not include an active polymer component.

[0055] Optionally, as described in more detail below, the body 14 and / or the cap 26 may be formed in a two-shot or three-shot injection molding process.

[0056] The active polymer component can include a base polymer loaded with one or more active agents and, therefore, may be referred to herein as an active agent loaded polymer or loaded polymer. The active agent in the active polymer component can include an absorbing material, an emitting material, and / or an activating material. Optionally, the active polymer component is a three-phase desiccant loaded polymer. The active polymer component can be provided in different shapes, volumes, and / or configurations. In one exemplary embodiment, the active polymer component is in the form of a solid plug or a generally planar member that extends into the interior space of the cap 26.

[0057] In one embodiment, the activated polymer component is a single-component desiccant-entrained polymer made from a single piece of material. The entrained polymer may include a base polymer (for structure), a desiccant (or other active agent), and optionally a channeling agent, with or without the desiccant or another active agent entrained therein. These types of activated entrained polymers and methods for making and using them are disclosed, for example, in Applicant's U.S. Patent Nos. 5,911,937, 6,214,255, 6,130,263, 6,080,350, 6,174,952, 6,124,006, and 6,221,446, as well as U.S. Patent Application Publication No. 2016 / 0039955, each of which is incorporated herein by reference in its entirety. Optionally, the entrained polymer may be in the form of a loose film, or may optionally be heat staked (eg, via heat sealing to a surface).

[0058] Alternatively, the desiccant may comprise loose desiccant beads or pouches containing them. While the exemplary embodiments herein reflect an active polymer component attached to, for example, cap 26 or body 14, it is contemplated that the active agent may be located in other locations and / or positions, such as on the sidewall of the body.

[0059] In embodiments in which each active member contains a desiccant, moisture absorption is desired. However, if moisture absorption is not desired, the active member can contain an alternative activator. For example, in another embodiment, the active member contains a material selected from the group consisting of activated carbon, carbon black, Ketjen black, and diamond powder. In a further embodiment, the activator comprising one or more layers of the active member contains materials such as absorbing particulates, BaTiO3, SrTiO3, SiO2, Al2O3, ZnO, TiO2, MnO, CuO, Sb2O3, silica, calcium oxide, and ion exchange resins. In yet another embodiment, the absorbent-containing layer of the active member contains two or more types of absorbents. Suitable absorbents are selected to achieve the desired vapor or gas absorption (e.g., absorption of moisture, oxygen, carbon dioxide, nitrogen, or other undesirable gases or vapors) for the desired end use.

[0060] The active component (whether a desiccant, oxygen scavenger, releasing material or component, etc., or a combination thereof) can act, interact, or react with a selected material (e.g., moisture or oxygen). Examples of such action or interaction can include absorption, adsorption (generally sorption), or release of the selected material. Each active component can be, for example, extruded or molded. Optionally, the active component can be formed (e.g., onto a substrate) in a desired shape or pattern via an in-line melt-bonding thermal bonding process.

[0061] The active material can include an "active ingredient" in a substrate. The active ingredient(s) can (i) be immiscible with the substrate (e.g., polymer) and not melt when mixed and heated with the base polymer and channeling agent, i.e., have a melting point higher than the melting point of either the base polymer or the channeling agent, and / or (ii) act on, interact with, or react with a selected material. The term "active ingredient" can include, but is not limited to, a material that absorbs, adsorbs, or releases a selected material(s). In accordance with the technology of the present disclosure, the active ingredient can be in the form of particles such as minerals (e.g., molecular sieves or silica gel in the case of desiccants), although the technology of the present disclosure should not be considered limited solely to particulate active agents. For example, in some embodiments, the oxygen scavenging formulation can be made from a resin that functions as an activator or as a component of an activator.

[0062] As used herein, the term "substrate" is a component (preferably a polymer) of an incorporated active material, other than the active agent, that provides the structure of the incorporated material.

[0063] As used herein, the term "base polymer" refers to a polymer having a gas transmission rate that is, optionally, significantly lower than, lower than, or substantially equal to that of the selected material. By way of example, such a transmission rate would be the water vapor transmission rate in embodiments where the selected material is moisture and the active ingredient is a water-absorbing desiccant. The primary function of the base polymer is to provide structure for the incorporated polymer. Suitable base polymers can include thermoplastic polymers, such as polyolefins such as polypropylene and polyethylene, polyisoprene, polybutadiene, polybutene, polysiloxane, polycarbonate, polyamide, ethylene-vinyl acetate copolymer, ethylene-methacrylate copolymer, poly(vinyl chloride), polystyrene, polyester, polyanhydride, polyacrylonitrile, polysulfone, polyacrylate, acrylic acid, polyurethane, and polyacetal, or copolymers or mixtures thereof.

[0064] With reference to such a comparison of the moisture vapor transmission rates of the base polymer and the channeling agent, in one embodiment, the channeling agent has a moisture vapor transmission rate that is at least twice that of the base polymer. In another embodiment, the channeling agent has a moisture vapor transmission rate that is at least five times that of the base polymer. In another embodiment, the channeling agent has a moisture vapor transmission rate that is at least ten times that of the base polymer. In yet another embodiment, the channeling agent has a moisture vapor transmission rate that is at least 20 times that of the base polymer. In yet another embodiment, the channeling agent has a moisture vapor transmission rate that is at least 50 times that of the base polymer. In yet another embodiment, the channeling agent has a moisture vapor transmission rate that is at least 100 times that of the base polymer.

[0065] As used herein, the term "channeling agent(s)" is defined as a material that is incompatible with the base polymer and has an affinity for transporting gas phase substances at a faster rate than the base polymer. Optionally, the channeling agent, when formed by mixing the base polymer with the channeling agent, can form channels through the entrained polymer. Optionally, such channels can allow selected materials to permeate through the entrained polymer at a faster rate than through the base polymer alone.

[0066] As used herein, the term "channel" or "interconnected channels" is defined as passages formed by a channeling agent that penetrate the base polymer and may interconnect with one another.

[0067] As used herein, the term "contaminated polymer" is defined as a monolithic material formed of at least a base polymer with an active agent and, optionally, a channeling agent, mixed or dispersed throughout. Contaminated polymers therefore include two-phase and three-phase polymers. A "mineral-filled polymer" is a type of contaminated polymer in which the active agent is in the form of a mineral, e.g., mineral particles such as molecular sieves or silica gel. The term "contaminated material" is used herein to mean a monolithic material that includes an active agent mixed into a substrate, which may or may not be a polymer.

[0068] As used herein, the terms "monolithic," "monolithic structure," or "monolithic composition" are defined as a composition or material that does not consist of two or more distinct macroscopic layers or portions. Thus, a "monolithic composition" does not include multilayer composites, although a monolithic composition may form a layer of such a composite.

[0069] As used herein, the term "phase" is defined as a part or component of a monolithic structure or composition that is uniformly distributed throughout so as to give the structure or composition its monolithic character.

[0070] As used herein, the term "selected material" is defined as a material that can be acted upon by, interact with, or react with an active agent and permeate through the channels of the entrained polymer. For example, in embodiments where a desiccant is used as the active agent, the selected material can be moisture or a gas that can be absorbed by the desiccant. In embodiments where an emitting material is used as the active agent, the selected material can be a drug released by the emitting material, such as moisture, a fragrance, or an antimicrobial agent (e.g., chlorine dioxide). In embodiments where an adsorbent material is used as the active ingredient, the selected material can be a certain volatile organic compound, and the adsorbent material can be activated carbon.

[0071] As used herein, the term "three-phase" is defined as a monolithic composition or structure comprising three or more phases. An example of a three-phase composition according to the disclosed technology is a mixed polymer formed from a base polymer, an active agent, and a channeling agent. Optionally, the three-phase composition or structure may include an additional phase, such as a colorant.

[0072] The compounded polymer can be a two-phase blend (i.e., a base polymer and an active ingredient without a channeling agent) or a three-phase blend (i.e., a base polymer, an active agent, and a channeling agent). Compounded polymers are described, for example, in U.S. Patent Nos. 5,911,937, 6,080,350, 6,124,006, 6,130,263, 6,194,079, 6,214,255, 6,486,231, 7,005,459, and U.S. Patent Application Publication No. 2016 / 0039955, as referenced above.

[0073] The entrained material or polymer includes a substrate (e.g., a polymer) to provide structure, optionally a channeling agent, and an active agent. The channeling agent forms microscopic interconnected channels through the entrained polymer. At least a portion of the active ingredient is contained within the channels such that these channels communicate between the active ingredient and the outside of the entrained polymer through the microscopic channel openings formed in the outer surface of the entrained polymer. The active ingredient can be, for example, any one of a variety of absorbing, adsorbing, or releasing materials, as described in more detail below. While a channeling ingredient is preferred, the technology of the present disclosure broadly encompasses entrained materials, optionally without a channeling agent, e.g., a two-phase polymer.

[0074] In any embodiment, suitable channeling agents may include polyglycols such as polyethylene glycol (PEG), ethylene vinyl alcohol (EVOH), polyvinyl alcohol (PVOH), glycerin polyamines, polyurethanes, and polycarboxylic acids, including polyacrylic acid or polymethacrylic acid. Alternatively, the channeling agent may be a water-insoluble polymer such as propylene oxide polymerisate-monobutyl ether, such as Polyglykol B01 / 240 from CLARIANT. In other embodiments, the channeling agent may be propylene oxide polymerisate-monobutyl ether, such as Polyglykol B01 / 20 from CLARIANT, propylene oxide polymerisate, such as Polyglykol D01 / 240 from CLARIANT, ethylene vinyl acetate, nylon 6, nylon 66, or any combination of the foregoing.

[0075] Suitable active ingredients according to the technology of the present disclosure include absorbent materials such as desiccants. When the active agent is a desiccant, any desiccant suitable for a given application can be used. Typically, physical absorption desiccants are preferred for many applications. These can include molecular sieves, silica gel, clay, and starch. Alternatively, the desiccant can be a chemical compound that forms crystals containing water, or a compound that reacts with water to form a new compound.

[0076] Optionally, in any embodiment, the activator may be an oxygen scavenger, for example, an oxygen scavenging resin formulation.

[0077] Figures 9-15 illustrate another optional embodiment of a secondary packaging 110 and device 112 combination of the disclosed technology. The combination illustrated in Figures 9-15 has certain components or aspects that are similar or identical to the combination illustrated in Figures 1-8 and discussed above. Accordingly, similar or identical structures between the embodiments of Figures 1-8 and 9-15 are distinguished by the reference numbers in Figures 9-15 being 100 higher than the reference numbers in Figures 1-8. A description of certain similarities between the embodiments of Figures 1-8 and 9-15 may be omitted herein merely for convenience and brevity.

[0078] In contrast to previous embodiments, the secondary packaging 110 of the presently disclosed embodiments is of one-piece or unitary design. Specifically, the cap 126 is pivotally attached to the body 114, optionally by at least one hinge 151. When the cap 126 is in the closed position, the cap 126 and the body 114 combine to form a cavity 116 (see FIG. 14 ) for holding and / or enclosing the device 112. The secondary packaging 110 can optionally have a clamshell configuration.

[0079] One distinguishing feature of the secondary packaging 110 is that it has at least one clip or attachment mechanism 152 positioned on or secured to its interior surface. The clip 152 may, but need not necessarily, be configured to surround and / or contact at least a portion of the device 112, all of the device 112. Each clip 152 may be configured to prevent or at least reduce the likelihood of the device 112 being inadvertently removed from the secondary packaging 110.

[0080] Optionally, the secondary packaging 110 and / or clip 152 may be configured such that the device 112 is aligned with the longitudinal axis A of the device 112. L(see FIG. 14 ), or the like. In one optional embodiment, at least a slight movement of such device 112 can help prevent damage to device 112 inside secondary packaging 110, such as when secondary packaging 110 is dropped.

[0081] In another optional embodiment, when device 112 is in and / or attached to clip 152, device 112 extends along its longitudinal axis A L fixed along the

[0082] In the optional embodiment shown, the secondary packaging 110 includes a single clip 152 configured to hold, directly grasp, and / or encircle at least a portion of a single device 112. However, the clip 152 can be designed to hold more than one device 112 in larger versions of the secondary packaging 110, or the secondary packaging 110 can include two or more spaced apart clips 152 each sized to hold one device 112. The clip 152 can also be configured to prevent inadvertent removal or movement of the device 112 relative to the body 114.

[0083] Optionally, the clip 152 is removably attached or permanently secured to the inner surface of the body 114 by, but not limited to, adhesive, mechanical fasteners (e.g., pins or screws), or press-fit or snap-fit engagement. The clip 152 is aligned with the longitudinal axis A of the secondary packaging 110. L (see FIG. 14 ) to the body 114 or at or near the midpoint of the body 114. Optionally, the longitudinal axis A of the secondary packaging 110 L is the axis defined by the hinge 151 (sometimes referred to herein as hinge axis A, as shown in FIG. 14). H ) extending parallel to the

[0084] The clip 152 may optionally include two opposing or spaced apart arcuate arms 153 a, 153 b. Each arm 153 a, 153 b may extend outward or away from the inner surface of the body 114 in a non-linear manner. Each arm 153 a, 153 b may be resilient or biased inward (e.g., to the position shown in FIGS. 14 and 15 ) so that the device 112 may be snap-fit onto the clip 152. Optionally, each arm 153 a, 153 b may be configured to move or flex at least slightly outward away from the device 112 to facilitate removal of the device 112 from the secondary packaging 110. Thus, each arm 153 a, 153 b may act as a spring to maintain the device 112 in a desired position or location.

[0085] Optionally, as shown in Figure 15, each arm 153a, 153b can have a uniform thickness from its base to its free end. In an alternative optional embodiment, each arm 153a, 153b can include a portion of reduced thickness or width. In such an embodiment, if or when the secondary package 110 is subjected to a sudden force, such as when the secondary package 110 is dropped, each arm 153a, 153b can flex at least slightly toward the body 114 in the thinned region or portion thereof.

[0086] 15, in one optional embodiment, each arm 153a, 153b can include at least one first portion 155 and at least one or two spaced apart second portions 157. Optionally, the first portion 155 can separate the two second portions 157. Each first portion 155 can be aligned along the longitudinal axis A of the device 112. D , and each second portion 157 may be concave relative to the longitudinal axis A of the device 112. DSuch a configuration allows the clip 152 to easily accommodate and / or receive the device 112, while securely retaining the device 112 once it is pressed sufficiently down into the clip 152.

[0087] Optionally, the entire clip 152, or one or more portions thereof, can be formed from metal, while the remainder of the secondary packaging 110 can be formed from a polymeric material. Optionally, the clip 152 and the remainder of the secondary packaging 110 can be formed from a polymeric material.

[0088] Optionally, as shown in FIGS. 13 and 14, the longitudinal axis A of the device 112 may be positioned within a clip 152. D is the longitudinal axis A of the secondary packaging 110 L or hinge axis A H The secondary package 110 extends at an angle θ that is not parallel or perpendicular to the longitudinal axis A of the device 112. The angle θ can optionally be between 10 and 80 degrees, optionally between 11 and 20 degrees, optionally between 12 and 16 degrees, optionally between 12.5 and 15 degrees, optionally between 13.3 degrees, optionally between 20 and 70 degrees, optionally between 18 and 22 degrees, optionally between 20 degrees, optionally between 30 and 60 degrees, optionally between 28 and 32 degrees, optionally between 30 degrees, optionally between 40 and 50 degrees, or optionally 45 degrees. The angle θ reduces the likelihood of damage to the device 112 if and / or when the secondary package 110 is subjected to a sudden force, such as when the secondary package 110 is dropped. Specifically, the angle θ changes the vector of the drop force(s), which changes the vector of the drop force(s) relative to the longitudinal axis A of the device 112. D This reduces the likelihood of the device 112 slipping and / or moving rapidly compared to when the falling direction is parallel to the direction of the drop.

[0089] In another optional embodiment, the longitudinal axis A of the device 112 D is the secondary packaging 110 or hinge axis A H Longitudinal axis A of L It extends parallel to

[0090] Another distinguishing feature of one optional embodiment of the secondary packaging 110 of the present embodiment is that the body 114 is designed and / or configured such that the clip 152 can only receive or hold the device 112 when the device 112 is pointing in one direction or in one orientation. For example, the secondary packaging 110 can optionally receive and hold the device 112 when the device is oriented in a first direction, but cannot receive and hold the device 112 when the device is oriented in an opposite, second direction.

[0091] To determine or at least contribute to the above-mentioned functions, as shown in Figures 13-15, at least two or four or more spaced apart prongs 136 may extend inward and / or upward from the inner surface of the body 114. Thus, each prong 136 may extend inward into the cavity 116 when the secondary packaging 110 is in the closed configuration. Each prong 136 may extend inwardly along the longitudinal axis A of the device 112. D 152. The clip 152 is spaced apart from the clip 152 along the length thereof.

[0092] Optionally, each prong 136 extends parallel to any other prong 136. Each prong 136 may be wider than it is thick and taller than it is wide. The base of each prong 136, which is attached to the inner surface of the body 114, may be larger or wider than the free end of each prong 136. A tapered or concave portion may be positioned between the base and the free end of each prong 136. The tapered or concave portion of each prong 136 may face the device 112 when the device is positioned within the clip 152. Thus, each tapered or concave portion may accommodate or complement at least a portion of the device 112 when the device 112 is held by the clip 152.

[0093] In one optional embodiment, two of the four spaced apart prongs 136 are aligned with the longitudinal axis A of the device 112. D1, and two of the four spaced apart prongs 136 are aligned along the longitudinal axis A of the device 112. D 152. The clip 152 is positioned on the opposite or second side along the

[0094] Optionally, the prongs 136 on the first side are closer to each other and / or closer to the longitudinal axis A of the device 112 than the prongs 136 on the second side. D In other words, the longitudinal axis A of the device 112 D A first pair of prongs 136, which face each other across the longitudinal axis A of the device 112, D The prongs 136 may be closer to each other than the second pair of prongs 136 that face each other across the prongs.

[0095] Such an arrangement allows the device 112 to be attached to the clip 152 when the device is pointing in a first direction (e.g., the nose of the device 112 is between the closer pair of prongs 136), but prevents the device 112 from being attached to the clip 152 when the device is pointing in an opposite second direction (e.g., if the user attempts to insert the end 112 of the handle apparatus between the closer pair of prongs 136).

[0096] In one optional embodiment, the clip 152 and prongs 136 are aligned with at least the longitudinal axis A of the device 112 when the device 112 is attached to the clip 152 and / or body 114. D Additionally, a portion of the prongs 136 may contact a portion of the device 112 to prevent or at least limit movement of the device 112 in a direction perpendicular to the longitudinal axis A of the device 112 when the device 112 is attached to the clip 152 and / or body 114. D For example, one or more of the prongs 136 may abut an outer surface or ledge of the device 112 to prevent movement of the device in a direction parallel to the longitudinal axis A of the device 112. DCertain movements of the device 112, such as in a direction parallel to the axis of rotation, can be prevented.

[0097] 9, 11, and 13-15, in one optional embodiment, the secondary packaging 110 may include a locking, latching, or closing mechanism. More specifically, the cap 126 may include a latch 138 extending at least partially therefrom. The latch 138 may be configured to engage at least a portion of the body 114, such as at least one protrusion or a plurality of spaced apart protrusions 140 extending from an outer surface of the body 114, to assist in maintaining the secondary packaging 110 in a closed configuration. Optionally, the plurality of spaced apart protrusions 140 may extend parallel to one another at or near a lateral central portion of the body 114.

[0098] Optionally, latch 138 may be a generally flat or planar portion with an internal groove or an opening 142 extending therethrough. Each protrusion 140 may optionally be sized, shaped, and / or configured to be at least slightly larger than opening 142 so that latch 138 may be snap-fit onto protrusion(s) 140. In the same or alternative arrangement, one or both ends of each protrusion 140 may include a catch that may extend through and / or around opening 142 to engage a face of latch 138 when secondary packaging 110 is in the closed configuration.

[0099] Engagement or contact between the latch 138 and the at least one protrusion 140 can maintain the secondary packaging 110 in a closed position. Optionally, the periphery of the opening 142 can engage with the protrusion(s) 140 when the secondary packaging 110 is in a closed configuration. In at least one optional embodiment, separation of the latch 138 from the at least one protrusion 140 is required to reconfigure the secondary packaging 110 from the closed position to the open position.

[0100] Optionally, the method of attaching one or more of the devices 112 to the secondary packaging 110 may include pivoting the cap 126 relative to the body 114 about the hinge 151 to move the secondary packaging 110 from a closed position to an open position to expose the cavity 116. The device 112 may then be placed, inserted, and / or snap-fit into the clip 152. In one optional embodiment, the device 112 must be oriented in a specific manner to be received by at least one pair of prongs 136; otherwise, the device 112 may not be able to contact and engage with the clip 152. Optionally, the latch 138 is separated from at least one prong 140 before pivoting the cap 126 relative to the body 114.

[0101] Figures 16-20 illustrate yet another alternative, optional embodiment of the combination of the disclosed technologies. The secondary packaging 110''' shown in Figures 16-20 has many components or aspects that are similar to the combination shown in Figures 9-15 and discussed above. Accordingly, similar or identical structures between the embodiments of Figures 9-15 and 16-20 are distinguished in Figures 16-20 by three primes (''). Description of certain similarities between the embodiments of Figures 9-15 and 16-20 may be omitted herein merely for convenience and brevity.

[0102] One distinguishing feature of the optional embodiment secondary packaging 110''' shown in Figures 16-20 is its ability to hold and / or protect two devices 112 when the secondary packaging 110''' is in a closed configuration. To accommodate the additional devices 112, the secondary packaging 110''' may be wider and / or longer, but not necessarily taller or thicker, than the secondary packaging 110 shown in Figures 9-15. The secondary packaging 110''' may optionally include two spaced-apart clips 152'''.

[0103] 20, the secondary packaging 110''' can optionally be configured to receive one of the devices 112 in a first orientation and a second device 112 in an opposite second orientation. The longitudinal axis A of each device 112 D is the longitudinal axis A of the secondary packaging 110''' L The prongs 136 may extend at an angle θ that is not parallel or perpendicular to the prongs 136'''. To allow for such an orientation, eight or more prongs 136''' are arranged in a staggered fashion.

[0104] The following exemplary embodiments further describe optional aspects of the disclosed technology and are part of the detailed description. These exemplary embodiments are not strictly claims of the present application, but are presented in a form substantially similar to claims (each having a numerical designation followed by a capital letter). The following exemplary embodiments are referenced to each other in a dependent relationship as "embodiments" instead of "claims."

[0105] 1A. A combination a device for administering a medicine or drug; a two-part secondary packaging configured to hold the device, the secondary packaging having a body and a cap separable therefrom, the body and cap being combined to form a cavity configured to sandwich the device therein.

[0106] 2A. The combination of embodiment 1A, wherein the device is an inhaler.

[0107] 3A. The combination of embodiment 2A, wherein the inhaler is reconfigurable between an inactivated configuration, in which the inhaler does not emit or dispense a medicine or agent, and an activated configuration, in which the inhaler emits or dispenses a medicine or agent.

[0108] 4A. The combination of embodiment 3A, wherein the secondary packaging is not moisture sealed when the cap is attached to the body.

[0109] 1B. A one-piece secondary package configured to hold an inhaler, the secondary package comprising: A secondary package comprising a cap pivotally attached to a body by a hinge, the cap and the body each including two spaced apart ribs extending inwardly therefrom, and at least one of the cap and the body including a clip on an inner surface thereof, the clip configured to removably receive an inhaler.

[0110] 2B. The secondary packaging of embodiment 1B, wherein each rib includes a notch therein, each notch sized and shaped to receive at least a portion of an inhaler.

[0111] 3B. The secondary packaging of embodiment 1B or 2B, wherein the clip comprises at least two opposing arcuate arms.

[0112] 4B. The secondary packaging of embodiment 1B, 2B, or 3B, wherein the secondary packaging is configured to prevent the device from being reconfigured from the inactivated position to the activated position when the cap is in the closed position.

[0113] 5B. The secondary packaging of any one of embodiments 1B-4B, wherein the inhaler is a nasal inhaler.

[0114] 1C. A secondary package configured to hold a device for administering a medicine or drug, the secondary package comprising: a body having a base and a sidewall extending upwardly from the base; a cap that can be removably attached to the main body; The secondary packaging, wherein the cap and body are combined to form a cavity for holding the device when the cap is attached to the body.

[0115] 2C. The secondary packaging of embodiment 1C, wherein when the device is in the cavity and the cap is attached to the body, at least a portion of the body and the cap are configured to prevent movement of the device that would otherwise release or administer the medicine or agent.

[0116] 3C. The secondary packaging of embodiment 1C or 2C, wherein one end of the side wall opposite the base of the body includes a rim that defines an opening leading to the inside of the body.

[0117] 4C. The secondary packaging of any one of embodiments 1C-3C, wherein the cap includes a top wall and a side wall extending downwardly therefrom, and the cap further includes an annular skirt extending downwardly from the side wall.

[0118] 5C. The secondary packaging of any one of embodiments 1C-4C, wherein at least a portion of the skirt is configured to fit within at least a portion of the side wall of the body when the cap is attached to the body.

[0119] 6C. The secondary packaging of any one of embodiments 1C-5C, wherein the entire skirt is configured to fit within at least a portion of the side wall of the base when the cap is attached to the body.

[0120] 7C. A secondary packaging described in any one of embodiments 1C to 6C, wherein the skirt includes at least one protrusion extending radially outward therefrom, and the sidewall of the body includes at least one opening or groove therein, and the at least one opening or groove in the sidewall of the body is configured to receive at least a portion of the at least one protrusion when the cap is attached to the body.

[0121] 8C. The secondary packaging of any one of embodiments 1C-7C, wherein the skirt comprises at least two spaced apart cutouts.

[0122] 9C. The secondary packaging of any one of embodiments 1C-8C, wherein the cap includes two opposing cap thumb tabs and the body includes two opposing body thumb tabs.

[0123] 10C. The secondary packaging of any one of embodiments 1C-9C, wherein simultaneous engagement of at least two of the opposing cap thumb tabs or body thumb tabs disengages at least one protrusion from at least one opening or groove.

[0124] 11C. A secondary packaging according to any one of embodiments 1C to 10C, wherein a ring extends inward from the inner surface of the base of the body, the ring being configured to receive a portion of the device therein when the device is installed within the body.

[0125] 12C. A secondary packaging according to any one of embodiments 1C to 11C, wherein the body includes at least two spaced apart lower fins extending inward from the inner surface of the side wall of the body, the lower fins combining to hold the device in a desired position within the secondary packaging.

[0126] 13C. A secondary packaging according to any one of embodiments 1C to 12C, wherein the cap includes at least two spaced apart upper fins extending inward from the inner surface of the side wall of the cap, the upper fins combining to hold the device in a desired position within the secondary packaging.

[0127] 14C. The secondary packaging of any one of embodiments 1C-13C, wherein the device is a nasal dose inhaler.

[0128] 1D. Combination a nasal dose inhaler; a secondary package configured to hold the nasal dose inhaler, the secondary package comprising: a body having a base and a sidewall extending upwardly from the base; a cap that can be removably attached to the main body; The cap and body are combined such that when the cap is attached to the body, the combination forms a cavity for holding the device.

[0129] 1E. A method of protecting a device for administering a medication, comprising providing a secondary packaging, the secondary packaging comprising: a clip attached to the inside of a body of the secondary packaging, the clip configured to hold the device stationary relative to the secondary packaging; and a device axis of the device extending at an angle relative to a hinge axis of the secondary packaging.

[0130] 2E. The method of embodiment 1E, wherein the angle then reduces the trauma or force experienced by the device in response to an impact on the secondary packaging.

[0131] While the technology of the present disclosure has been described in detail and with reference to specific examples thereof, it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof. It is therefore understood that the technology of the present disclosure is not limited to the particular embodiments disclosed, but is intended to encompass modifications within the spirit and scope of the technology of the present disclosure.

Claims

1. 1. A secondary package configured to hold at least one device for administering a medicament, said secondary package comprising: a body including at least one clip attached to an interior surface thereof, the at least one clip configured to encircle at least a portion of the at least one device, the clip configured to prevent inadvertent removal or movement of the at least one device relative to the body; a cap pivotally attached to the body, the cap and the body combining to form a cavity for holding the at least one device when the cap is in a closed position relative to the body.

2. 10. The secondary packaging of claim 9, wherein the at least one device is a nasal dose inhaler.

3. 10. The secondary packaging of any one of the preceding claims, wherein the body is configured such that the at least one clip can only receive the at least one device when the at least one device is pointing in a certain direction.

4. 4. The secondary package of claim 3, wherein at least two spaced apart prongs extend inwardly or upwardly from the inner surface of the body, the at least two spaced apart prongs being spaced apart from the at least one clip.

5. 5. The secondary package of claim 4, wherein the at least two spaced apart prongs comprises at least four spaced apart prongs.

6. 6. The secondary packaging of claim 5, wherein two of the at least four spaced apart prongs are on a first side of a device axis that extends at an angle to a hinge that attaches the body to a cover, and two of the at least four spaced apart prongs are on a second side of the device axis.

7. 10. The secondary packaging of any one of the preceding claims, wherein when the at least one device is attached to the body, the body is configured to prevent movement of the at least one device that would otherwise release or administer the agent.

8. 10. The secondary packaging of any one of the preceding claims, wherein when the at least one device is attached to the body, the at least one device defines a device axis that extends at an angle relative to a hinge axis, and optionally the angle is between 10 and 80 degrees, optionally between 11 and 20 degrees, optionally between 12 and 16 degrees, optionally between 12.5 and 15 degrees, optionally between 13.3 degrees, optionally between 20 and 70 degrees, optionally between 18 and 22 degrees, optionally 20 degrees, optionally between 30 and 60 degrees, optionally between 28 and 32 degrees, optionally 30 degrees, optionally between 40 and 50 degrees, or optionally 45 degrees.

9. 10. The secondary packaging of any one of the preceding claims, wherein the at least one clip comprises two spaced apart arcuate arms.

10. 10. The secondary packaging of claim 9, wherein each arcuate arm of the at least one clip includes a first portion that is concave relative to the device axis and at least one second portion that is convex relative to the device axis.

11. 10. The secondary packaging of any one of the preceding claims, wherein the cap includes a latch extending at least partially therefrom, the latch configured to engage at least one protrusion extending from an outer surface of the body.

12. 12. The secondary package of claim 11, wherein the latch includes an opening therein, the periphery of the opening configured to engage with the at least one protrusion when the secondary package is in the closed position.

13. 10. The secondary packaging of any one of the preceding claims, wherein the at least one device comprises two devices, the two devices extending in opposite directions when attached to the body.

14. 1. A method of attaching at least one device for administering a medication to a secondary packaging, said method comprising: pivoting a cap of the secondary package relative to a body of the secondary package about a hinge of the secondary package to move the secondary package from a closed configuration to an open configuration to expose a cavity; placing the at least one device for administering the medication within at least one clip attached to an inner surface of the body of the secondary packaging, the at least one clip configured to surround at least a portion of the at least one device, and the clip configured to prevent inadvertent removal or movement of the at least one device relative to the body.

15. 15. The method of claim 14, wherein the device axis of the at least one device extends at an angle relative to the hinge axis of the secondary packaging.

16. 15. The method of claim 14, wherein the angle is between 10 and 80 degrees, optionally between 11 and 20 degrees, optionally between 12 and 16 degrees, optionally between 12.5 and 15 degrees, optionally between 13.3 degrees, optionally between 20 and 70 degrees, optionally between 18 and 22 degrees, optionally 20 degrees, optionally between 30 and 60 degrees, optionally between 28 and 32 degrees, optionally 30 degrees, optionally between 40 and 50 degrees, or optionally 45 degrees.

17. The method of any one of claims 14 to 16, wherein the at least one device is a nasal dose inhaler.

18. 18. The method of any one of claims 14 to 17, wherein the body is configured such that the at least one clip can only receive the at least one device when the at least one device is pointing in a certain direction.

19. 20. The method of claim 18, wherein at least two spaced apart prongs extend inward or upward from the inner surface of the body, the at least two spaced apart prongs being spaced apart from the at least one clip.

20. 20. The method of claim 19, wherein the at least two spaced apart prongs comprises four spaced apart prongs.

21. 21. The method of claim 20, wherein two of the four spaced apart prongs are on a first side of a device axis that extends at an angle to a hinge that attaches the body to a cover, and two of the four spaced apart prongs are on a second side of the device axis.

22. The method of any one of claims 14 to 21, wherein the at least one clip includes two spaced apart arcuate arms.

23. 23. The method of claim 22, wherein each arcuate arm of the at least one clip includes a first portion that is concave relative to the device axis and at least one second portion that is convex relative to the device axis.

24. A method according to any one of claims 14 to 23, wherein a latch on the cover is disengaged from at least one projection extending from an outer surface of the body before pivoting the cover relative to the body.

25. 25. The method of any one of claims 14 to 24, wherein the device is prevented from being able to be placed in the at least one clip by not being able to orient the device in a particular manner before placing the device in the clip.

26. It is a combination, The secondary packaging of claim 1; and at least one nasal dose inhaler.

27. 1. A method of treating a patient in need of an intranasally administered medication, said method comprising:

14. Providing a secondary packaging according to any one of claims 1 to 13 with a medication delivery device stored therein, the medication delivery device comprising a body having an ejection end defining a medication ejection port and an opposite actuator end, the medication delivery device including a medication reservoir having a medication stored therein, the medication delivery device further including an actuator for expelling the medication from the reservoir through the ejection port, the actuator extending from the actuator end of the body, the actuator being linearly movable from an extended position to a depressed position, the ejection port being sealed when the actuator is in the extended position and the ejection port being open when the actuator is in the depressed position, the actuator being operable to eject the medication from the reservoir in response to axial movement of the actuator from the extended position to the depressed position; removing the medication delivery device from the secondary packaging; inserting the discharge end into the patient's nostril; and actuating the drug delivery device to intranasally administer the drug to the patient.

28. 28. The method of claim 27, wherein the medicament is a formulation comprising one or more of the following active pharmaceutical ingredients: naloxone, ketamine, midazolam, fentanyl, lorazepam, nalmefene, epinephrine, apomorphine, cetrorelix, loxapine, eletriptan, ketorolac, glucagon, and olanzapine.

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