Medical infusion device system with extended dosage range

Abstract

The present invention relates to a medical infusion device system including a first dosing chamber for delivering at least a first minimum dose of a liquid medicament, a second dosing chamber for delivering at least a second minimum dose of the liquid medicament, fluid lines operatively connected to the first and second dosing chambers for carrying a total amount of the liquid medicament delivered by the first and second dosing chambers to an outlet of the fluid line, and a controller for controlling the total amount of the liquid medicament, wherein the second minimum dose of the liquid medicament delivered by the second dosing chamber is greater than the first minimum dose of the liquid medicament delivered by the first dosing chamber to quickly and accurately deliver relatively small and large doses.

Description

[Technical Field]

[0001] The present invention relates to a medical infusion device system comprising a first dosing chamber configured to deliver one or more first minimum doses of liquid medication, a second dosing chamber configured to deliver one or more second minimum doses of liquid medication, a fluid line operably coupled to the first dosing chamber and the second dosing chamber for carrying a total amount of liquid medication for delivery by the first dosing chamber and the second dosing chamber to an outlet of the fluid line, and a controller configured to control the total amount of liquid medication for delivery through the fluid line by operating the first dosing chamber and the second dosing chamber. [Background technology]

[0002] Known medical infusion device systems are used to administer liquid medication to a user. The liquid medication is intended to improve the patient's health. During use, the liquid medication is dispensed by a first dosing chamber and a second dosing chamber. Thus, both the first dosing chamber (at least a first minimum dose) and the second dosing chamber (at least a second minimum dose) combine to form a total amount of liquid medication. The operation of the first dosing chamber and the second dosing chamber are controlled by a controller. The first dosing chamber and the second dosing chamber are operated with the same type of liquid medication.

[0003] However, when two dispensing chambers contribute to the total amount of liquid medication delivered to a patient, the overall dosing accuracy of a previously known medical infusion system is based on the dosing accuracy of the first dispensing chamber and the dosing accuracy of the second dispensing chamber. Care must be taken to ensure the total dosage does not result in over- or under-dosing of the liquid medication. Particularly when delivering small amounts of liquid medication, deviations in the amount of delivered liquid medication can be significant relative to the overall dosage. For example, due to individual needs and metabolic characteristics, various users of known medical infusion systems may have different dosage requirements. Infants often require lower doses of liquid medication than adults, and there is often a higher risk of overdosing infants when using medical infusion systems used by both infants and adults. Such known medical infusion systems exhibit overall dosing accuracy that is a compromise between lighter patients requiring smaller dosages administered with higher dosing accuracy and heavier patients requiring larger dosages administered with lower dosing accuracy. In a medical infusion system having two chambers, the overall dosage accuracy is based on the dosage accuracy of the first dosage chamber and the dosage accuracy of the second dosage chamber. Summary of the Invention

[0004] It is therefore an object of the present invention to provide a medical infusion device system that avoids at least one of the problems associated with medical device systems known from the prior art, and in particular to provide a medical infusion device system that allows for more variable dosing of liquid medication.

[0005] At least one of the above objectives is achieved by providing the subject matter disclosed in the claims and throughout the specification.

[0006] According to a first aspect, a medical infusion device system is provided, comprising: a first dosing chamber configured to deliver one or more first minimum doses of liquid medicament; a second dosing chamber configured to deliver one or more second minimum doses of liquid medicament; a fluid line operatively coupled to the first dosing chamber and the second dosing chamber to carry a total amount of liquid medicament delivered by the first dosing chamber and the second dosing chamber to an outlet of the fluid line; and a controller configured to control operation of the first dosing chamber and the second dosing chamber to deliver the total amount of liquid medicament through the fluid line, wherein the second minimum dose of liquid medicament delivered by the second dosing chamber is greater than the first minimum dose of liquid medicament delivered by the first dosing chamber.

[0007] The first and second minimum dosages are intrinsic parameters of the first and second dispensing chambers, respectively. The first and second minimum dosages are determined by the underlying structure, mechanism, and electronics of the first and second dispensing chambers, respectively, as well as any additional components of the medical infusion device system required to operate the first and second dispensing chambers, respectively, to deliver a dosage of liquid medication. For example, the minimum dosage of each of the first and second dispensing chambers is equal to the minimum volume that can be delivered by the first or second dispensing chamber, respectively, to ambient air, i.e., no other pressure greater than the pressure of ambient air prevents the first or second dispensing chamber from flowing out of its respective outlet. The first and second minimum dosages cannot be further reduced by separately operating the first and second dosing chambers, i.e., the first and second minimum dosages are the minimum amounts that can be repeatedly delivered by operating the first and second dosing chambers, respectively, with a standard deviation of ±5% at the settings of the medical infusion device. The first minimum dosage is the smallest possible volume that can be delivered by operating the first dosing chamber. Similarly, the second minimum dosage is the smallest possible volume that can be delivered by operating the second dosing chamber.

[0008] However, because the first and second minimum dosage amounts are used together to form the total amount of liquid medication delivered through the outlet of the fluid line of the medical infusion device system, the first and second minimum dosage amounts can be used to modify the total amount of liquid medication that can then be delivered through the fluid line. The first minimum dosage amount can be added to the second minimum dosage amount, and vice versa. That is, the second minimum dosage amount can also be added to the first minimum dosage amount. This allows for an amount greater than just one or more second minimum dosage amounts or just one or more first minimum dosage amounts, respectively, thereby enabling the total dosage to be expanded by using both the first and second dosage chambers. In particular, by dividing the total amount of liquid medication to be administered into multiple amounts of the first and second minimum dosage amounts, the accuracy of each of the first and second dosage chambers can be utilized to deliver the total amount of liquid medication with high precision.

[0009] The first minimum dosage and the second minimum dosage are different volumes, and the second minimum dosage is greater than the first minimum dosage, i.e., the first dosage is smaller than the second minimum dosage. Thus, a relatively large volume can be delivered to a user of the medical infusion device system by delivering one or more second minimum dosages. Providing a relatively large volume by delivering one or more second minimum dosages is faster than delivering the relatively large volume by respectively delivering more first dosages.

[0010] While controlling the operation of the first and second dosing chambers, a total volume can be delivered by actuating the second dosing chamber to deliver a relatively large volume and actuating the first dosing chamber to deliver a relatively small volume. Thus, the total delivered volume can be advantageously expanded to exceed the maximum volume that can be delivered by the second dosing chamber by simultaneously delivering volumes from the first and second dosing chambers. In the sense of the present invention, a controller is an electrotechnical component configured to control the operation of the first and second dosing chambers. For example, the controller can be a microprocessor. "Operably coupled" refers to a configuration of the medical device system in which a fluid line is in fluid communication with the first and second dosing chambers, thereby allowing liquid medicament from the first and / or second dosing chambers to flow out of the respective dosing chambers through an outlet.

[0011] According to an embodiment of the present invention, the outlet of the fluid line may be formed by or operably connected to a cannula or an infusion set. The connection may be irreversible or reversible, preferably reversible. The cannula may be a steel cannula or a soft cannula, preferably a soft cannula.

[0012] According to an embodiment of the present invention, a medical infusion device system can include an infusion pump having a first dosing chamber, a second dosing chamber, fluid lines, and a controller. The controller can be located within the infusion pump or can be a separate device, such as a remote control, communicatively connected to the infusion pump. The remote control can be a mobile device or a personal computer. The infusion pump can be a patch pump, i.e., a body-wearable pump that includes an adhesive layer for temporarily adhering the body-wearable pump to a patient's body.

[0013] The liquid medication can be any kind of insoluble pharmaceutical agent, in particular, the liquid medication can be insulin or glucagon.

[0014] According to an embodiment, the controller is configured to simultaneously operate the first dosing chamber and the second dosing chamber to transfer an amount of liquid medication equal to one or more first minimum dosage amounts to the second dosing chamber and / or to transfer an amount of liquid medication equal to one or more second minimum dosage amounts to the first dosing chamber.

[0015] The controller not only controls the operation of the first and second dosing chambers to deliver the liquid medicament through the outlet of the fluid line, but also controls the simultaneous operation of the first and second dosing chambers to transfer the liquid medicament from one of the first or second dosing chambers to the other of the first or second dosing chambers. For example, one or more minimum first doses can be transferred from the first dosing chamber to the second dosing chamber, or vice versa. Furthermore, one or more minimum second doses can be transferred from the second dosing chamber to the first dosing chamber, or vice versa. The controller can thereby advantageously be used to balance the fill levels within the first and second dosing chambers. This transfer of liquid to the first dosing chamber can be advantageous when a very small amount of liquid medication is typically to be delivered to a particular patient, such as a low-weight patient such as a child, and that small amount is below the minimum dosage that can be delivered by the second dosing chamber. Thus, refilling the first dosing chamber expands the total volume of liquid medication that can be delivered by the first dosing chamber at a dosage that is below the minimum dosage of the second dosing chamber but exceeds the total volume of the first dosing chamber.

[0016] For example, if a relatively large amount of liquid medicament is to be delivered through the outlet of the fluid line, the liquid medicament can be first transferred from a first dosing chamber to a second dosing chamber during an idle state. Once the liquid medicament is transferred from the first dosing chamber to the second dosing chamber, the relatively large amount can be delivered through the outlet of the fluid line secondarily by controlling only the operation of the second dosing chamber. Thus, the delivery rates of the first and second dosing chambers can be utilized to advantage rather than supplying a relatively large amount of liquid medicament by controlling the operation of the first dosing chamber, which may take longer than when using the second dosing chamber.

[0017] According to an embodiment of the present invention, the controller is configured to control simultaneous operation of the first dosing chamber and the second dosing chamber to deliver a total amount of liquid drug through the outlet via the fluid line, the total amount of liquid drug equal to the sum or difference of one or more first minimum doses of liquid drug and one or more second minimum doses of liquid drug, and the total amount of liquid drug delivered to the outlet is zero or greater than zero.

[0018] Simultaneous operation of the first and second dosing chambers can transfer at least a first dosage or multiple thereof to the second dosing chamber, or at least a second dosage or multiple thereof to the first dosing chamber. Therefore, a first minimum dosage or multiple thereof can be subtracted from a second minimum dosage. Vice versa. That is, a second minimum dosage or multiple thereof can be subtracted from the first minimum dosage. The total amount of liquid drug dispensed by controlling the first and second dosing chambers can be the sum of the first minimum dosage or multiple thereof and the second minimum dosage or multiple thereof, or the total amount of liquid drug dispensed by simultaneously operating the first and second dosing chambers can be the difference between one or more first minimum dosages and one or more second minimum dosages. However, when subtracting, the total amount of liquid drug should not be a negative amount. This can result in liquid medication and / or bodily fluids being drawn from the patient through the outlet. Because of the transfer of liquid medication from the first dosing chamber to the second dosing chamber, or vice versa, dosing accuracy does not affect the medication delivered by the medical infusion device system. However, the transfer of liquid medication from one dosing chamber to another allows users to tailor the configuration of the medical infusion device system to their individual needs. For example, a user who frequently administers small amounts of liquid medication may need to refill the first dosing chamber more frequently.

[0019] Thus, in embodiments, the controller is configured to control operation of the first and second dosing chambers to deliver a total amount of liquid medicament through the fluid line, the total amount being zero or greater than zero. This safety mechanism is associated with the benefit of preventing liquid from entering the outlet or the fluid line. In embodiments, the medical infusion device system includes a sensor configured to detect negative pressure at the outlet, the sensor operably coupled to the controller to prevent the liquid medicament from flowing through the outlet into the first and / or second dosing chambers. Additionally or alternatively, the medical infusion device system can include a check valve that prevents the liquid medicament from flowing through the outlet into the first and / or second dosing chambers.

[0020] According to an embodiment of the present invention, the first dispensing chamber is operably coupled to a first drive mechanism for operating the first dispensing chamber, and the second dispensing chamber is operably coupled to a second drive mechanism for operating the second dispensing chamber, and a controller is configured to control the operation of the first drive mechanism and the second drive mechanism. The operation of the first drive mechanism can be controlled by the controller to dispense a liquid drug from the first dispensing chamber or to insert a liquid drug into the first dispensing chamber. Similarly, the operation of the second drive mechanism can be controlled by the controller to dispense a liquid drug from the second dispensing chamber or to insert a liquid drug into the second dispensing chamber. Thus, because the first drive mechanism is operably coupled to the first dispensing chamber and the second drive mechanism is operably coupled to the second dispensing chamber, controlling the operation of the first drive mechanism and the second drive mechanism also controls the operation of the first dispensing chamber and the second dispensing chamber, and therefore the total amount of liquid drug flowing through the fluid line. "Operably coupled" in this context means that the drive mechanism is configured to effect the evacuation or filling, respectively, of the liquid medicament in the respective dosing chamber.

[0021] According to an embodiment of the present invention, the first dosing chamber is a first reservoir configured to contain a liquid medicament, and the first dosing chamber comprises a first plunger movably disposed within the first reservoir to deliver one or more first minimum doses of the liquid medicament when actuated by a first drive mechanism, wherein the second dosing chamber is a second reservoir configured to contain a liquid medicament, and the second dosing chamber comprises a second plunger movably disposed within the second reservoir to deliver one or more second minimum doses of the liquid medicament when actuated by a second drive mechanism.

[0022] A first drive mechanism moves a first plunger within a first reservoir. The first reservoir forms a first dosing chamber. By advancing the first plunger within the first reservoir in a first direction, liquid medicament is dispensed from the first reservoir. When the first plunger is moved by the first drive mechanism in a second direction opposite the first direction, liquid medicament is drawn into the first reservoir. Similarly, a second drive mechanism moves a second plunger within a second reservoir. The second reservoir forms a second dosing chamber. When the second plunger is advanced within the second reservoir in a third direction, liquid medicament is dispensed from the second reservoir. When the second plunger is moved within the second reservoir in a fourth direction opposite the third direction, liquid medicament is drawn into the second reservoir. Thus, the first plunger is configured to displace one or more first minimum doses, and the second plunger is configured to displace one or more second minimum doses.

[0023] According to an embodiment of the present invention, the first reservoir has a first cross-sectional area, and the second reservoir has a second cross-sectional area that is different from the first cross-sectional area. For example, the second cross-sectional area of ​​the second reservoir can be larger than the first cross-sectional area of ​​the first reservoir. By having different sized cross-sectional areas, the delivery volume delivered when moving the first plunger a distance within the first reservoir is less than the delivery volume delivered by moving the second plunger a similar distance within the second reservoir. "Cross-sectional area" refers to the area of ​​the plunger that is in contact with the liquid medicament during use of the medical infusion device system.

[0024] According to an embodiment of the present invention, the second minimum dosage is equal to an integer multiple of the first minimum dosage. Because the second minimum dosage is greater than the first minimum dosage, the first minimum dosage is equal to half or less of the second minimum dosage. For example, the second minimum dosage can be equal to x times the first minimum dosage, where x is an integer equal to 2, 3, 4, 5, 6, 7, 8, 9, or 10. Thus, the total amount of liquid medication can be one or more second minimum dosages plus or minus one or more first minimum dosages. Thus, both large and small amounts of liquid medication can be delivered by the medical infusion device system relatively quickly and with high accuracy, compared to a medical infusion device system having only one or two dosing chambers capable of delivering the same minimum dosage. For example, the first minimum dosage can be 0.01 mL, 0.001 mL, 0.0001 mL, 0.0001 mL, or 0.00001 mL.

[0025] At least one of the above objects is also solved by a method for operating a medical infusion device system according to one or more of the preceding embodiments, the method including the step of controlling operation of a first dosing chamber and a second dosing chamber by a controller to supply a total quantity of liquid drug through a fluid line, the total quantity of liquid drug being greater than or equal to zero, and the total quantity of liquid drug equal to one or more first minimum dosage amounts plus or minus one or more second minimum dosage amounts.

[0026] Further advantages, features and technical effects of the present invention will be apparent from the following description of the embodiments and the accompanying drawings. [Brief explanation of the drawings]

[0027] [Figure 1] 1 shows a schematic diagram of a medical infusion device system according to an embodiment of the present invention. [Figure 2a] 2 shows a first mode of operation of the medical infusion device system according to FIG. 1; [Figure 2b] 2 illustrates a second mode of operation of the medical infusion device system according to FIG. 1. [Figure 2c] 10 illustrates a third mode of operation of the medical infusion device system according to FIG. [Figure 2d] 10 illustrates a fourth mode of operation of the medical infusion device system according to FIG. DETAILED DESCRIPTION OF THE INVENTION

[0028] FIG. 1 shows a schematic diagram of a medical infusion device system 1 according to an embodiment of the present invention. The medical infusion device system 1 includes a first dosing chamber 1 and a second dosing chamber 2. The first dosing chamber 2 forms a first reservoir configured to hold a liquid medicament. A first plunger 2b is movable within the reservoir, and movement of the first plunger 2b is caused by a first drive mechanism 2a. A fluid line 4 is operably coupled to the first dosing chamber 2. Thus, when moved forward in a first direction, the liquid medicament is dispensed from the first reservoir into the fluid line 4. When moved in a direction opposite to the first direction, the liquid medicament is drawn into the first dosing chamber 2.

[0029] The fluid line 4 is further operably connected to the second dosing chamber 3. The second dosing chamber 3 forms a second reservoir configured to hold the same amount of liquid medicament as that contained in the first dosing chamber 2. A second plunger 3b is movably disposed within the second dosing chamber 3, and the movement of the second plunger 3b is guided by a second drive mechanism 3a. Similar to the movement of the first plunger 2b, moving the second plunger 3b in a second direction forces the liquid medicament contained in the second dosing chamber 3 into the fluid line 4, while moving the second plunger 3b in a direction opposite to the second direction causes the liquid medicament to enter the second dosing chamber 3.

[0030] The operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by a controller 6. The controller 6 is configured to control the operation of the first dosing chamber 2 and the second dosing chamber 3 to deliver a total amount of liquid medicament through a fluid line 4. The fluid line 4 includes an outlet 5, where the outlet 5 is connected to a cannula.

[0031] The first dosing chamber 2 is configured to deliver one or more first minimum doses of liquid medicament. Similarly, the second dosing chamber 3 is configured to deliver one or more second minimum doses of liquid medicament, and the second minimum doses of liquid medicament delivered by the second dosing chamber 3 are greater than the first minimum doses of liquid medicament delivered by the first dosing chamber 2. The total amount of liquid medicament is formed by adding or subtracting one or more first minimum doses and one or more second doses. Here, the cross-section of the first dosing chamber 2 is smaller than the cross-section of the second dosing chamber 3. Therefore, the amount of liquid delivered by the first dosing chamber 2 when the first plunger 2b is moved a certain distance is less than the amount of liquid delivered by the second dosing chamber 3 when the second plunger 3b is moved the same distance. In FIG. 1c,

[0032] Figures 2a-2d illustrate four exemplary modes of operation of medical infusion device system 1 according to the embodiment of Figure 1. Controller 6 is configured to control the operation of first dosing chamber 2 and second dosing chamber 3, thereby controlling the total amount of liquid medicament delivered via fluid line 4 and outlet 5 of fluid line 4.

[0033] The first operating mode is shown schematically in FIG. 2a. According to the first operating mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6 to further advance the first plunger 2b and the second plunger 3b within the first dosing chamber 2 and the second dosing chamber 3, respectively. Thus, the liquid medicament is dispensed from the first dosing chamber 2 and the second dosing chamber 3 into the fluid line 4. Thus, at least a first minimum dose delivered by the first dosing chamber 2 and at least a second minimum dose delivered by the second dosing chamber 3 add up to a total liquid volume. In FIG. 2a, the flow of the liquid medicament and the movement of the respective first plunger 2b and second plunger 3b are indicated by arrows.

[0034] The second operating mode is shown diagrammatically in FIG. 2b. According to the second operating mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6 such that the first plunger 2b retracts within the first reservoir formed by the first dosing chamber 2, and the second plunger 3b simultaneously advances further within the second reservoir formed by the second dosing chamber 3. However, the first minimum dose(s) drawn into the first dosing chamber 2 by retracting the first plunger 2b within the first dosing chamber 2 are smaller than the second minimum dose(s) delivered by further advancing the second plunger 3b within the second dosing chamber 3. Thus, there is a resulting total liquid volume dispensed via the fluid line 4 and the outlet 5. Again, in FIG. 2b, the flow of liquid medication and the corresponding movement of the first plunger 2b and the second plunger 3b are indicated by arrows. A portion of the amount of liquid dispensed from second dosing chamber 3 is transferred to first dosing chamber 2, and the remainder of the amount of liquid dispensed from second dosing chamber 3 is delivered through outlet 5 of fluid line 4. The total amount delivered through outlet 5 is equal to the amount of liquid medication delivered by second dosing chamber 3 minus the amount of liquid medication drawn into first dosing chamber 2.

[0035] 2c schematically illustrates a third operation mode of the medical injection device system 1 according to FIG. 1. According to the third operation mode, the operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6. The first drive mechanism 2a and the second drive mechanism 3a are operated to simultaneously move the first plunger 2b inside the first dosing chamber 2 and the second plunger 3b inside the second dosing chamber 3. Under the control of the controller 6, the first plunger 2b is retracted inside the first dosing chamber 3 by the first drive mechanism 2a, and the second plunger 3b is further advanced inside the second dosing chamber 3. The amount of liquid medicament drawn into the first dosing chamber 2 by retracting the first plunger 2b inside the first dosing chamber 2 is equal to one or more first minimum doses. At the same time, the amount of liquid medicament dispensed from the second dosing chamber 3 by further advancing the second plunger 3b within the second dosing chamber 3 is equal to the amount of liquid medicament drawn into the first dosing chamber 2. Therefore, the total amount of liquid medicament dispensed through the outlet 5 of the fluid line 4 is zero. Therefore, this mode of operation ensures that the liquid medicament is completely transferred from the second dosing chamber 3 to the first dosing chamber 2.

[0036] Similarly, the liquid medicament can be transferred from the first dosing chamber 2 to the second dosing chamber 3 by a fourth operating mode, as schematically visualized in FIG. 2d. The operation of the first drive mechanism 2a and the operation of the second drive mechanism 3a are controlled by the controller 6. Under the control of the controller, the first drive mechanism 2a is operated to further advance the first plunger 2b within the first dosing chamber 2, while the second drive mechanism 3a is operated to simultaneously retract the second plunger 3b within the second dosing chamber 3. The amount of liquid medicament dispensed from the first dosing chamber 2 is equal to one or more first minimum doses. The amount of liquid medicament drawn into the second dosing chamber 3 by retracting the second plunger 3b within the second dosing chamber 3 is equal to the amount of liquid medicament delivered by the first dosing chamber 2 and is also equal to one or more second minimum doses. [Explanation of symbols]

[0037] 1 Medical infusion system 2. First Dosing Chamber 2a First drive mechanism 2b First plunger 3 Second Dosing Chamber 3a Second drive mechanism 3b Second plunger 4 fluid lines 5 Fluid line outlet 6 Controller

Claims

1. A medical infusion device system (1), comprising: a first dosing chamber (2) configured to deliver one or more first minimum doses of liquid medicament; a second dosing chamber (3) configured to deliver one or more second minimum doses of said liquid medicament; a fluid line (4) operatively connected to the first and second dosing chambers (2, 3) for delivering a total amount of liquid medicament supplied by the first and second dosing chambers (2, 3) through an outlet (5) of the fluid line (4); and a controller (6) configured to control the operation of the first dosing chamber (2) and the second dosing chamber (3) to deliver the total amount of liquid medicament through the fluid line (4); Equipped with 1. A medical infusion device system (1), characterized in that the second minimum dose of the liquid medicament delivered by the second dosing chamber (3) is greater than the first minimum dose of the liquid medicament delivered by the first dosing chamber (2).

2. 2. The medical infusion device system of claim 1, wherein the controller is configured to control simultaneous operation of the first dosing chamber and the second dosing chamber to transfer an amount of liquid medicament equal to one or more of the first minimum doses to the second dosing chamber and / or to transfer an amount of liquid medicament equal to one or more of the second minimum doses to the first dosing chamber.

3. 3. The medical infusion device system of claim 1, wherein the controller is configured to control simultaneous operation of the first dosing chamber and the second dosing chamber to deliver the total amount of liquid medicament via the fluid line and through the outlet, the total amount of liquid medicament being equal to the sum or difference of one or more of the first minimum doses of liquid medicament and one or more of the second minimum doses of liquid medicament, and the total amount of liquid medicament delivered through the outlet is zero or greater than zero.

4. 4. The medical infusion device system (1) of claim 1, wherein the first dosing chamber (2) is operably coupled to a first drive mechanism (2a) configured to operate the first dosing chamber (2), the second dosing chamber (3) is operably coupled to a second drive mechanism (3a) configured to operate the second dosing chamber (3), and the controller (6) is configured to control the operation of the first drive mechanism (2a) and the second drive mechanism (3a).

5. 5. The medical injection device system of claim 4, wherein the first dosing chamber (2) is a first reservoir configured to contain the liquid medicament, the first dosing chamber comprising a first plunger (2b) movably disposed within the first reservoir to deliver the one or more first minimum doses of liquid medicament when actuated by the first drive mechanism (2a), and the second dosing chamber (3) is a second reservoir configured to contain the liquid medicament, the second dosing chamber comprising a second plunger (3b) movably disposed within the second reservoir to deliver the one or more second minimum doses of liquid medicament when actuated by the second drive mechanism (3a).

6. 6. The medical infusion device system (1) of claim 5, wherein the first reservoir has a first cross-sectional area and the second reservoir has a second cross-sectional area different from the first cross-sectional area.

7. 7. A medical infusion device system (1) according to any one of claims 1 to 6, characterized in that the second minimum dosage is equal to an integer multiple of the first minimum dosage.

8. 8. A method for operating a medical infusion device system (1) according to any one of claims 1 to 7, wherein the controller (6) controls operation of the first dosing chamber (2) and the second dosing chamber (3) to deliver the total amount of liquid medicament through the fluid line (4), the total amount of liquid medicament being zero or greater than zero, the total amount of liquid medicament being equal to one or more of the first minimum dosage amounts plus or minus one or more of the second minimum dosage amounts.

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