Projection patch and manufacturing method thereof

Abstract

The present invention provides a protrusion patch comprising an adhesive layer and a number of patterned protrusions attached to one surface of the adhesive layer at a distance from each other, the patterned protrusions containing a drug and a drug carrier, and the protrusions having a solvent content of 10 to 11 wt %, and a method for manufacturing the same.

Description

[Technical Field]

[0001] The present invention relates to a protrusion patch and a method for manufacturing the same. [Background technology]

[0002] The skin is approximately 1.5m in an adult. 2 The skin is considered the largest organ in the human body, with a surface area of ​​1000 m², making it a desirable route for drug administration. However, the outermost layer of the stratum corneum, which protects the human body from harmful chemicals, makes it difficult for high molecular weight and hydrophilic molecules to pass through this membrane. Among various approaches to improve transdermal drug delivery, the use of protrusions as a non-invasive method is a promising approach to increase the permeability of the skin to drugs.

[0003] Unlike hypodermic needles, the prongs allow for a painless and non-invasive approach to drug administration, are safer after use, and have low disposal costs.

[0004] The protrusions form microchannels in the skin, which allow drug molecules to be easily transported through them into the dermis. Various studies have shown that intradermal administration of certain drugs using protrusions increases therapeutic effects compared to intramuscular and subcutaneous routes. Therefore, the protrusions can provide a route for transdermal drug delivery for molecules that are not easily absorbed locally.

[0005] The bumps are typically fabricated using molding techniques, where the molds are created through complex microfabrication processes in clean rooms. These processes include photolithography using deep X-ray lithography (LIGA) and ultraviolet (UV) lithography. However, these methods are extremely time-consuming and require advanced clean room facilities, which excessively increases manufacturing costs.

[0006] In addition, the protrusions are generally needle-shaped, but needles of this shape have a small contact area with the skin, making it difficult to deliver drugs effectively and quickly, and especially when applied to a wound, they irritate the wound and hinder the therapeutic effect. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Korean Patent No. 10-2369762 Summary of the Invention [Problem to be solved by the invention]

[0008] The present invention has been devised to solve the above-mentioned problems of the prior art. The present invention aims to provide a protrusion patch and a method for manufacturing the same, which significantly increases the contact area between the protrusions and the skin to increase the drug delivery rate, effectively delivers drugs over a wide area without irritating the wound when applied to a wound, increases the contact area between the skin and the adhesive layer to stably attach the patch to the skin, and significantly reduces the number of manufacturing steps to significantly reduce manufacturing costs.

[0009] Another object of the present invention is to provide a protrusion patch that can prevent the protrusions from detaching from the adhesive layer during punching and has excellent productivity and quality, and a method for manufacturing the same. [Means for solving the problem]

[0010] In order to achieve the above object, the present invention Adhesive layer and The adhesive layer includes a plurality of patterned protrusions attached to one surface thereof at intervals, the patterned protrusions include a drug and a drug carrier; The protrusions provide a protrusion patch with a solvent content of 10-11% by weight.

[0011] The present invention also provides a) laminating a protrusion-formed sheet on one surface of an adhesive sheet; b) punching a number of patterned protrusions into a protrusion-forming sheet; c) removing the projection-formed sheet from the adhesive sheet by punching to remove the patterned projections; the patterned protrusions include a drug and a drug carrier; The method for producing a protrusion patch of the present invention provides the method, wherein the protrusion-formed sheet has a solvent content of 10 to 11% by weight.

[0012] The present invention also provides a) laminating a protrusion-formed sheet on one surface of a first adhesive sheet; b) punching a large number of patterned protrusions into the protrusion-forming sheet; c) removing the projection-formed sheet from the first adhesive sheet by punching to remove the patterned projections; d) laminating a second adhesive sheet on the upper surface of the patterned protrusions; e) separating the second adhesive sheet and the protrusions adhered thereto from the first adhesive sheet; the patterned protrusions include a drug and a drug carrier; The method for producing a protrusion patch of the present invention provides the method, wherein the protrusion-formed sheet has a solvent content of 10 to 11% by weight. [Effects of the Invention]

[0013] The protrusion patch of the present invention includes patterned protrusions, Significantly increasing the contact area between the protrusions and the skin, significantly increasing the drug delivery rate, When applied to a wound, unlike conventional needle-like protrusions, it effectively delivers drugs over a wide area without irritating the wound. Since the protrusions can be easily formed by a punching process, the number of manufacturing steps can be significantly reduced, thereby providing the effect of enabling inexpensive production.

[0014] Furthermore, since the patterned protrusions are directly bonded to the adhesive layer without a separate support, the area of ​​the adhesive layer that comes into contact with the skin is significantly increased compared to conventional patches that use a separate support.

[0015] Furthermore, the method for producing the protrusion patch of the present invention is much simpler than conventional methods and provides high productivity, thereby providing the effect of significantly reducing the production cost of the protrusion patch.

[0016] The present invention also provides a protrusion patch and a manufacturing method thereof, in which the protrusions are prevented from separating from the adhesive layer during punching, and which has excellent productivity and quality. [Brief explanation of the drawings]

[0017] [Figure 1] 1 is a cross-sectional view schematically showing one embodiment of the protrusion patch of the present invention. [Figure 2] 1 is a cross-sectional view schematically showing one embodiment of the protrusion patch of the present invention. [Figure 3] 1 is a diagram schematically illustrating one embodiment of a method for producing a protrusion patch of the present invention. [Figure 4] 1 is a diagram schematically illustrating one embodiment of a method for producing a protrusion patch of the present invention. [Figure 5] 1 is a diagram schematically illustrating another embodiment of the method for producing a protrusion patch of the present invention. [Figure 6] 1 is a diagram schematically illustrating another embodiment of the method for producing a protrusion patch of the present invention. [Figure 7] 1 is a photograph of a protrusion patch manufactured in Example 1 of the present invention. [Figure 8] 1 is a photograph of a protrusion patch manufactured in Example 2 of the present invention. [Figure 9] 1 is a photograph of a protrusion patch manufactured in Comparative Example 1. [Figure 10] 1 is a photograph of a protrusion patch manufactured in Comparative Example 2. DETAILED DESCRIPTION OF THE INVENTION

[0018] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0023] The present invention will now be described in detail with reference to the accompanying drawings, so that those skilled in the art can easily understand the present invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. The same reference numerals are used throughout the specification to refer to similar parts.

[0019] 1 and 2 are cross-sectional views schematically illustrating one embodiment of a protrusion patch according to the present invention. As shown in FIG. 1, the protrusion patch (100) of the present invention comprises an adhesive layer (20) and a number of patterned protrusions (10) attached to one surface of the adhesive layer (20) at intervals. The patterned protrusions (10) contain a drug and a drug carrier, and the protrusions may contain 10 to 11 wt % of a solvent relative to the total weight of the protrusions. When the solvent content is within this range, the protrusions are not fixed to the adhesive layer during punching, preventing them from detaching and resulting in the production of defective products, thereby providing excellent production efficiency and quality.

[0020] If the solvent is less than 10 wt%, the adhesion of the protrusions to the adhesive layer may be insufficient and they may easily detach from the adhesive layer during punching, whereas if the solvent is more than 11 wt%, the protrusions may adhere to the punching device and detach from the adhesive layer.

[0021] The solvent may be one or more selected from water (for example, distilled water), lower alcohols, glycerin, etc., and preferably water. As the water, distilled water may be preferably used.

[0022] In the protrusion patch of the present invention, the patterned protrusions (10) are attached directly to the adhesive layer (20) without a support, exposing the adhesive layer that is covered by the support in conventional patches, further improving the adhesive strength of the patch. In other words, because the adhesive surface is present not only at both ends of the patch but also in the center, the area of ​​the adhesive layer that adheres to the skin is dramatically increased compared to conventional techniques in which protrusions are formed on a support. This increased adhesive surface area of ​​the adhesive layer allows the protrusions (10) to maintain a stronger adhesion to the skin.

[0023] Furthermore, for this reason, even if the skin adhesion surface is uneven or the wearer moves, a much better adhesion state can be maintained compared to conventional techniques.

[0024] In one embodiment of the present invention, the patterned protrusions may have a maximum width of 0.1 mm to 50 mm, preferably 1 mm to 10 mm, and a height of 0.01 mm to 1 mm, preferably 0.01 mm to 0.1 mm.

[0025] The protrusions may be formed in the shape of a cylinder, an elliptical cylinder, or a polygonal prism. When the protrusions are formed in a polygonal prism shape, the surface that contacts the skin becomes flat, thereby greatly increasing the contact area between the protrusions and the skin, thereby significantly improving the drug delivery rate. Furthermore, when the protrusion patch is applied to a wound, unlike conventional needle-shaped protrusions, the drug can be effectively delivered through a wide area without irritating the wound. For example, when hyaluronic acid, an acne prevention or treatment agent, etc. are contained in the protrusions, the drug can be effectively delivered through a wide contact area, thereby providing excellent therapeutic effects. Furthermore, in the case of an acne treatment agent, the drug can be effectively delivered without irritating the acne.

[0026] Furthermore, when the protrusions are formed in a polygonal columnar shape as described above, they can be easily formed by a punching process, which significantly reduces the number of manufacturing steps, thereby improving productivity and significantly reducing the manufacturing cost of the protrusion patch.

[0027] In one embodiment of the present invention, the protrusion patch (100) may include a number of protrusions arranged at uniform intervals, or may include one or more groups of protrusions spaced apart from one another, with the protrusions in each group arranged at uniform intervals.

[0028] In one embodiment of the present invention, a support substrate (30) may be further provided on the other side of the adhesive layer, as shown in Figure 2. In addition, an upper cover (not shown) may be further provided on the upper side of the adhesive layer to which the protrusions are attached, and the support substrate (30) and upper cover may be any material known in the art without limitation. For example, the support substrate (30) may be a polyurethane film, and the upper cover may be a release film.

[0029] The component configurations of the pressure-sensitive adhesive layer and protrusions of the present invention will be described in more detail below.

[0030] [Adhesive layer] In one embodiment of the present invention, the adhesive layer (20) can be made of a material known in the art, and the material is not particularly limited.

[0031] The pressure-sensitive adhesive layer (20) may contain a synthetic rubber component. Examples of the synthetic rubber include isoprene / isoprene copolymer, polydimethylsiloxane, butyl rubber, ethylene-vinyl acetate copolymer, ethylene-ethyl acrylate copolymer, poly(alkyl vinyl ether) (e.g., poly(propyl vinyl ether), poly(isopropyl vinyl ether), poly(butyl vinyl ether)), poly(2-methylpropene), poly(ethylethylene), poly(1,2-dimethylethylene), ethylethylene-1,2-dimethylethylene copolymer, polyisoprene, polybutadiene, styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, etc., and these may be used alone or in combination of two or more.

[0032] The content of the synthetic rubber is not particularly limited, but may be 5 to 50 wt %, preferably 10 to 30 wt %, and more preferably 15 to 25 wt % of the total weight of the adhesive layer. If the content of the synthetic rubber is less than 5 wt %, the internal cohesion of the adhesive layer may decrease, and if it exceeds 50 wt %, the adhesive layer may become hard and the adhesiveness may decrease.

[0033] The pressure-sensitive adhesive layer (20) may contain a tackifier. The tackifier is not particularly limited, but examples thereof include polybutenes, rosin-based resins, terpene-based resins, petroleum-based resins (e.g., petroleum-based aliphatic hydrocarbon resins, petroleum-based aromatic hydrocarbon resins, petroleum-based aliphatic-aromatic copolymer hydrocarbon resins, petroleum-based alicyclic hydrocarbon resins (hydrogenated aromatic hydrocarbon resins), etc.), and coumarone-based resins. Among these, petroleum-based alicyclic hydrocarbon resins (hydrogenated aromatic hydrocarbon resins), such as hydrogenated hydrocarbon (C=6-20) polymers (Hydrogenated Poly(C6-20 Olefin)), are preferred. The tackifiers may be used alone or in combination of two or more.

[0034] The tackifier may be present in an amount of 20 to 50 wt %, preferably 35 to 45 wt %, based on the total weight of the adhesive layer. If the tackifier content is less than 20 wt %, the adhesiveness may be insufficient, whereas if it exceeds 50 wt %, the adhesive layer may be damaged, which is undesirable.

[0035] The pressure-sensitive adhesive layer (20) may contain carboxymethyl cellulose, which may be contained in an amount of 20 to 45% by weight, preferably 25 to 32% by weight, based on the total weight of the pressure-sensitive adhesive layer.

[0036] The pressure-sensitive adhesive layer (20) may contain oils. Components known in the art can be used as the oils, and mineral oils are preferred. The oils may be contained in an amount of 5 to 20 wt %, more preferably 8 to 13 wt %, based on the total weight of the pressure-sensitive adhesive layer.

[0037] In addition to the above components, the adhesive layer (20) may further contain additives commonly used in this field, which may be contained in an amount of 1 to 10 wt % based on the total weight of the adhesive layer.

[0038] The pressure-sensitive adhesive layer of the present invention can be produced by applying a pressure-sensitive adhesive layer-forming composition to a release liner, drying the composition, and laminating a support substrate on the pressure-sensitive adhesive layer. Alternatively, the pressure-sensitive adhesive layer can be produced on a support by directly applying the pressure-sensitive adhesive layer-forming composition to a support substrate and drying the composition.

[0039] [Patterned protrusions] The patterned protrusions dissolve or gel at a certain rate upon contact with the skin, thereby enabling the drug to be released.

[0040] The protrusions may include a drug, a drug carrier, and a solvent.

[0041] The drug may be any drug that can be administered transdermally, including, for example, general anesthetics, hypnotics / sedatives, antiepileptics, antipyretics / analgesics / anti-inflammatory drugs, drugs for treating vertigo, psychoneurotic drugs, central nervous system drugs, antidementia drugs, local anesthetics, skeletal muscle relaxants, autonomic nervous system drugs, antispasmodics, antiparkinsonian drugs, antihistamines, cardiac stimulants, antiarrhythmic drugs, diuretics, antihypertensive drugs, vasoconstrictors, coronary vasodilators, peripheral vasodilators, arteriosclerosis drugs, circulatory system drugs, respiratory stimulants, antitussives / expectorants, hormone drugs, topical drugs for suppurative diseases, analgesics / antipruritics / astringents / anti-inflammatory drugs, drugs for parasitic skin diseases, hemostatic drugs, drugs for treating gout, drugs for diabetes, drugs for treating malignant tumors, antibiotics, chemotherapy drugs, narcotics, hyaluronic acid, preventive and therapeutic agents for acne, and smoking cessation aids.

[0042] Furthermore, the drug is not limited to a free base drug, but also includes physiologically acceptable salts thereof. The salts are not particularly limited, and examples thereof include formates, acetates, lactates, adipates, citrates, tartrates, methanesulfonates, fumarates, maleates, etc., and examples of addition salts with inorganic acids include hydrochlorides, sulfates, nitrates, phosphates, etc. The drug may be a solvate, hydrate, or non-hydrate.

[0043] Specifically, hyaluronic acid, acne prevention and treatment agents, etc. may be used.

[0044] The drug carrier may be a component that is gelled by a solvent released from the skin and that releases the drug contained in the drug carrier as a result of the gelling of the drug support layer. For example, one or a combination of two or more selected from the group consisting of hyaluronic acid, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (NaCMC), poloxamer, carbomer, hypromellose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), sodium alginate, sugars, glycerin, propylene glycol, polyethylene glycol 400, and sorbitol (SB) may be used.

[0045] The saccharide may be one or more selected from the group consisting of monosaccharides, disaccharides, and polysaccharides. More specifically, the monosaccharide may be one or more selected from the group consisting of fructose, galactose, glucose, and mannose. The disaccharide may be one or more selected from the group consisting of sucrose, lactose, maltose, trehalose, turanose, and cellobiose. The polysaccharide may be one or more selected from the group consisting of dextran, diethylaminoethyl dextran, dextrin, cellulose, and β-glucans.

[0046] The solvent may be water (for example, distilled water), a lower alcohol, glycerin, or the like, and preferably water. As the water, distilled water may be preferably used.

[0047] The protrusions may contain 0.1 to 20 wt% of a drug, 69 to 89 wt% of a drug carrier, and 10 to 11 wt% of a solvent. Furthermore, they may further contain 0.1 to 10 wt% of functional additives and / or general additives known in the art. In the above, water (e.g., distilled water) may be preferably used as the solvent.

[0048] Although the structure of the protrusion patch of the present invention has been described above, it should not be understood that the protrusion patch of the present invention includes only the components described above. It should be understood that the protrusion patch of the present invention may additionally include components that are obvious to those skilled in the art, although not described in this specification.

[0049] The method for producing the protrusion patch of the present invention will be described below with reference to an example.

[0050] The protruding patch of the present invention is as shown in FIG. a) laminating a protrusion-forming sheet (12) on one surface of an adhesive sheet (20); b) punching a large number of patterned protrusions into the protrusion-forming sheet (12); c) removing the projection-formed sheet (12) from the adhesive sheet (20) by punching, excluding the patterned projections.

[0051] the patterned protrusions include a drug and a drug carrier; The protrusion-formed sheet may have a solvent content of 10 to 11% by weight.

[0052] The contents described above regarding the protrusion patch are all applicable to all manufacturing methods of the present invention, and therefore, the overlapping contents will be omitted below.

[0053] The components of the protrusion-formed sheet are the same as the components of the protrusions described above.

[0054] The method for manufacturing the protrusion patch of the present invention has the feature of greatly reducing the number of manufacturing steps compared to the prior art, and therefore can greatly reduce the manufacturing cost of the protrusion patch.

[0055] The projection-formed sheet can be manufactured in sheet form by a method known in this field.

[0056] In one embodiment of the present invention, a supporting substrate (30) can be further attached to the other surface of the pressure-sensitive adhesive sheet before step (a) or after step (c).

[0057] Furthermore, the protrusion patch of the present invention, as shown in FIG. Before laminating the protrusion-formed sheet on one side of the adhesive sheet in step a), 1) A step of laminating a release film (40) to one side of an adhesive sheet (20); 2) punching out the center of the release film (40) to an area where the protrusion will be arranged, and removing the punched central release film (40) to form a hollow portion, The projection-formed sheet (12) is laminated so as to be covered by the hollow portion and the remaining release film, In step b), the step of punching a large number of patterned protrusions into the protrusion-formed sheet is performed on the protrusion-formed sheet placed in the hollow portion, In the step c), when removing the protrusion-formed sheet (12) from the adhesive sheet (20) excluding the protrusions patterned by punching, the release film (40) is also removed.

[0058] In another embodiment of the present invention, the protruding patch, as shown in FIG. a) laminating a protrusion-forming sheet (12) on one surface of a first adhesive sheet (50); b) punching a large number of patterned protrusions (12) into the protrusion-forming sheet (12); c) removing the projection-formed sheet (12) from the first adhesive sheet (50) except for the projections (10) patterned by punching; d) laminating a second adhesive sheet (20) on the upper surface of the patterned protrusions (10); e) Separating the second adhesive sheet (20) and the protrusions (10) attached thereto from the first adhesive sheet (50).

[0059] the patterned protrusions include a drug and a drug carrier; The protrusion-formed sheet may have a solvent content of 10 to 11% by weight.

[0060] In the manufacturing method, the second adhesive sheet may have a stronger adhesive strength to the protrusions than the first adhesive sheet.

[0061] In the step d), the second adhesive sheet may further have a supporting substrate (30) laminated on the surface other than the surface to which the projections are adhered.

[0062] In one embodiment of the present invention, as shown in FIG. Before laminating the protrusion-formed sheet (12) on one side of the first adhesive sheet (50) in step a), 1) A step of laminating a release film (40) to one surface of a first adhesive sheet (50); 2) punching out the center of the release film (40) to an area where the protrusion will be arranged, and removing the punched central release film (40) to form a hollow portion, The projection-formed sheet (12) is laminated so as to be covered by the hollow portion and the remaining release film (40), In step b), the step of punching a large number of patterned protrusions (10) into the protrusion-formed sheet (12) may be performed on the protrusion-formed sheet placed in the hollow portion.

[0063] Hereinafter, the present invention will be described in detail with reference to examples in order to specifically explain the present invention. However, the examples according to the present invention can be modified in various other aspects, and the scope of the present invention should not be construed as being limited to the examples described below. The examples of the present invention are provided to more completely explain the present invention to those skilled in the art.

[0064] Example 1: Fabrication of protruding patches (1) Manufacturing of protrusion-formed sheets A composition for a protrusion-forming sheet was prepared by mixing 5 wt% hyaluronic acid as the drug, 1.2 wt% hydrolyzed collagen, 50 wt% polyvinylpyrrolidone (PVP) and 28.5 wt% polyvinyl alcohol as drug carriers, 2.1 wt% pullulan, 1.2 wt% PEG-60 hydrogenated castor oil, and 1.5 wt% sodium chloride, and 10.5 wt% distilled water as the solvent. The composition was applied to a polyethylene terephthalate (PET) liner (75 μm thick) that had been treated with a silicone release agent to produce a 40 μm thick protrusion-forming sheet.

[0065] (2) Manufacturing of adhesive sheets An adhesive component was obtained by mixing 43 parts by weight of hydrogenated hydrocarbon (C=6-20) polymer (Hydrogenated Poly(C6-20 Olefin)), 18 parts by weight of isoprene-styrene copolymer (Styrene / Isoprene Copolymer), 28 parts by weight of carboxymethyl cellulose, and 11 parts by weight of mineral oil.

[0066] The adhesive component was applied to a polyethylene terephthalate (PET) liner (75 μm thick) that had been treated with a silicone release agent, and after drying, the thickness was 300 μm. A moisture-permeable and waterproof polyurethane film was then attached to produce an adhesive sheet.

[0067] (3) Manufacturing of protruding patches The projection-formed sheet produced in (1) above was laminated on one surface of the adhesive layer of the adhesive sheet produced in (2) above.

[0068] The projection-formed sheet was punched using a punching machine with a diameter of 1.25 mm.

[0069] The remaining protrusion-forming sheet, excluding the patterned protrusions formed by punching from the adhesive layer, was removed from the adhesive layer. Thereafter, the adhesive layer and the patterned protrusions were covered with a release paper, and the sheet was placed in a wrapping paper and sealed to prepare a protrusion patch.

[0070] Example 2: Fabrication of protruding patches A protrusion patch was manufactured in the same manner as in Example 1, except that the amount of polyvinyl alcohol used in manufacturing the protrusion-formed sheet was reduced to 28 wt % and the amount of distilled water used was increased to 11 wt %.

[0071] Comparative Example 1: Production of protruding patch A protrusion patch was manufactured in the same manner as in Example 1, except that the amount of polyvinyl alcohol used in manufacturing the protrusion-formed sheet was increased to 29.7 wt % and the amount of distilled water used was reduced to 9.3 wt %.

[0072] Comparative Example 2: Production of protrusion patch A protrusion patch was manufactured in the same manner as in Example 1, except that the amount of polyvinyl alcohol used in manufacturing the protrusion-formed sheet was reduced to 27.8 wt % and the amount of distilled water used was increased to 11.2 wt %.

[0073] Test Example 1: Quality evaluation of protrusion patches The shapes of the protrusion patches manufactured in the examples and comparative examples were photographed with a camera and evaluated.

[0074] The evaluation results are shown in Figures 7 to 10. Figure 7 is a photograph of the protruding patch of Example 1 of the present invention, and Figure 8 is a photograph of the protruding patch of Example 2 of the present invention. As can be seen from Figures 7 and 8, protruding patches of excellent quality were manufactured in the case of Examples 1 and 2 of the present invention.

[0075] Meanwhile, Figure 9 is a photograph of the protrusion patch of Comparative Example 1, and Figure 10 is a photograph of the protrusion patch of Comparative Example 2. As can be seen from Figures 9 and 10, in the case of the protrusion patches of Comparative Examples 1 and 2, the protrusions detached from the adhesive layer during punching, resulting in the production of defective products.

[0076] Therefore, from the above experiment, it was found that the protrusions must contain a solvent in the range of 10 to 11 wt %; if the solvent content is outside this range, the protrusions will not be fixed to the adhesive layer and will detach during punching, resulting in the production of defective products.

[0077] Similarly, the projection-formed sheet also needs to contain a solvent in the range of 10 to 11% by weight.

[0078] Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the following claims also fall within the scope of the present invention. [Explanation of symbols]

[0079] 10: Protrusion 12: Protrusion forming sheet 20: Adhesive layer (second adhesive layer) 30: Support base material 40: Release film 50: 1st adhesive layer 100: Protruding patch

Claims

1. Adhesive layer and The adhesive layer includes a plurality of patterned protrusions attached to one surface thereof at intervals, the patterned protrusions include a drug and a drug carrier; The protrusion patch is characterized in that the protrusions have a solvent content of 10 to 11% by weight.

2. The protrusion patch according to claim 1 , wherein the solvent is at least one selected from the group consisting of water, a lower alcohol, and glycerin.

3. The protrusion patch according to claim 1, wherein the patterned protrusions have a maximum width of 0.1 mm to 50 mm and a height of 0.01 mm to 1 mm.

4. The patch of claim 1 , wherein the protrusions are in the shape of a cylinder, an elliptical cylinder, or a polygonal prism.

5. The protrusion patch according to claim 1 , wherein the drug is a transdermal drug.

6. The protruding patch according to claim 5, wherein the drug is hyaluronic acid.

7. The drug carrier may be hyaluronic acid, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (NaCMC), poloxamer, carbomer, hypromellose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), sodium alginate (sodium 2. The protrusion patch according to claim 1, wherein the protrusion patch is one or a combination of two or more selected from the group consisting of alginate, sugars, glycerin, propylene glycol, polyethylene glycol 400, and sorbitol (SB).

8. The protrusion patch according to claim 1 , further comprising a support substrate on the other side of the adhesive layer.

9. a) laminating a protrusion-formed sheet on one surface of an adhesive sheet; b) punching a large number of patterned protrusions into a protrusion-forming sheet; c) removing the projection-formed sheet, excluding the projections patterned by punching, from the adhesive sheet; the patterned protrusions include a drug and a drug carrier; 2. The method for manufacturing a protrusion patch according to claim 1, wherein the protrusion-forming sheet has a solvent content of 10 to 11 wt %.

10. The method for manufacturing a protrusion patch according to claim 9 , wherein the protrusions are in the shape of a cylinder, an elliptical cylinder, or a polygonal prism.

11. The method for manufacturing a protrusion patch according to claim 9, wherein a supporting substrate is further attached to the other surface of the adhesive sheet before step a) or after step c).

12. In step a), before laminating the protrusion-formed sheet on one surface of the adhesive sheet, 1) laminating a release film to one side of the adhesive sheet; 2) punching out the center of the release film to an area where the protrusion will be arranged, and removing the punched central release film to form a hollow portion, the protrusion-formed sheet is laminated so as to be covered by the hollow portion and the remaining release film, In step b), the step of punching a large number of patterned protrusions into the protrusion-formed sheet is performed on the protrusion-formed sheet placed in the hollow portion, 10. The method for manufacturing a protrusion patch according to claim 9, wherein in step c), when removing the protrusion-forming sheet from the adhesive sheet, excluding the protrusions patterned by punching, the release film is also removed.

13. a) laminating a protrusion-formed sheet on one surface of a first adhesive sheet; b) punching a large number of patterned protrusions into a protrusion-forming sheet; c) removing the projection-formed sheet from the first adhesive sheet, except for the projections patterned by punching; d) laminating a second adhesive sheet on the upper surface of the patterned protrusions; e) separating the second adhesive sheet and the protrusions adhered thereto from the first adhesive sheet; the patterned protrusions include a drug and a drug carrier; The method for manufacturing a protrusion patch according to claim 1, wherein the protrusion-forming sheet has a solvent content of 10 to 11% by weight.

14. The method for manufacturing a protrusion patch according to claim 13, wherein the protrusions are in the shape of a cylinder, an elliptical cylinder, or a polygonal prism.

15. The method for manufacturing a protrusion patch according to claim 13, wherein the adhesive strength of the second adhesive sheet to the protrusions is greater than the adhesive strength of the first adhesive sheet to the protrusions.

16. The method for manufacturing a protrusion patch according to claim 13, wherein in step d), a supporting substrate is further laminated on the other side of the second adhesive sheet than the side to which the protrusions are adhered.

17. In step a), before laminating the protrusion-formed sheet on one surface of the first adhesive sheet, 1) laminating a release film to one surface of a first adhesive sheet; 2) punching out the center of the release film to an area where the protrusion will be arranged, and removing the punched central release film to form a hollow portion, the protrusion-formed sheet is laminated so as to be covered by the hollow portion and the remaining release film, 14. The method for manufacturing a protrusion patch according to claim 13, wherein in step b), the step of punching a large number of patterned protrusions into the protrusion-formed sheet is performed on the protrusion-formed sheet placed in the hollow portion.

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