Use of the composition for giving the skin a vibrant glow

Abstract

The present invention relates to the use of a composition that gives skin a vibrant glow.More specifically, the present invention relates to topical application that makes skin look fresh, youthful, and firm, and makes skin look radiant.This topical application is realized by using a composition that contains a combination of vitamin C and vitamin E.It has been found that this topical application is also effective when delivered through cleansing compositions.

Description

[Technical Field]

[0001] The present invention relates to the use of compositions that impart a vibrant glow to the skin, and more particularly to topical applications that give the skin a fresh, youthful, firm appearance and a radiant appearance. [Background technology]

[0002] People generally like to look good and feel good about themselves because of it. In addition to eating good food and living a healthy lifestyle, such as breathing clean air and getting a balanced amount of exercise, people also turn to cosmetics to bring their appearance closer to what they perceive as beautiful appearance elements. Skin is the largest organ in the human body and the organ most visible to the outside world. With regard to skin, most consumers desire to have an even skin tone free of blemishes, hyperpigmentation, wrinkles, and visible signs of acne. A large number of cosmetic products are available to provide one or more of the above benefits.

[0003] Many of the above problems are exacerbated by natural aging and internal and external stresses, such as light, excessive sunlight, pollution, hormonal changes, and psychological stress. The inventors have set out to provide solutions to some of the above problems and have developed technology that results in products that even skin tone, brighten skin, and cover visible signs of skin aging such as wrinkles.

[0004] Vibrant radiance is another benefit that some products on the market have offered. Vibrant radiance refers to the skin having a fresh, youthful appearance and a firm appearance, which makes the skin more rejuvenated and better protected from external and internal stressors. Active substances available on the market that claim to provide this benefit include, for example, Oli'Vine™ ST, a product sold by Gattefosse. This product has the INCI name Water (and) Olivine Extract. The use of such active substances has been shown to increase ATP (adenosine triphosphate) levels and reduce intracellular oxidation, which are key processes that provide the claimed benefits to the skin.

[0005] The inventors hope to achieve these benefits using safe, inexpensive, and known, commonly available ingredients, and have discovered a unique combination of vitamins at very low concentrations that surprisingly works even when incorporated into cleansing compositions.The inventors have found that a combination of vitamin C and vitamin E, when used in wash-off compositions at low concentrations of less than 20 ppm, works synergistically to provide skin with a vibrant glow, as evidenced by the resulting ATP levels.The inventors are not aware of any published information that suggests either of these active substances to increase ATP levels.Therefore, it was truly surprising to the inventors that a combination of two active substances, neither of which is known to increase ATP levels, can synergistically interact to provide skin with a vibrant glow.It was even more surprising that this could be achieved when incorporated into wash-off compositions at very low concentrations of less than 20 ppm.

[0006] Database GNPD (online); Mintel; January 6, 2021, "15 Vitamin C + Hyaluronic acid", XP093011390, Database Accession No. 8382495. Database GNPD (online); Mintel; August 21, 2022, "Clarifying facial cleanser", XP093041221, Database Accession No. 9832656. These Mintel references describe several combinations of vitamin C and vitamin E.

[0007] U.S. Patent Application Publication No. 2018 / 325804 discloses a five-ingredient skin care regimen, each comprising a composition made from a combination of bleached muscadine (Vitis rotundifolia) pomace solvent extract, beta-glucan, and grape seed extract, to improve skin appearance. These compositions may further comprise other ingredients present in amounts sufficient to improve skin appearance, such as panthenol, vitamins A, C, and E, superoxide dismutase, Schizandra chinensis extract, Lotus japonicus extract, or any combination thereof.

[0008] U.S. Patent Application Publication No. 2022218594 (Carle Tiffany et al.) discloses a composition and a method for using the composition for cosmetic purposes. The composition may contain tetrahexyldecyl ascorbate, Phyllanthus emblica fruit extract, tocopherol, and ascorbic acid. The composition may further contain plant amino acids. An effective amount of the composition can be applied to the skin to stimulate collagen production and lysyl oxidase activity, inhibit tyrosinase, inhibit melanogenesis and / or COX-1 activity, and inhibit matrix metalloproteinase enzyme activity in the skin.

[0009] European Patent Application Publication No. 2637636 (Unilever) provides a leave-on non-solid skin conditioning composition comprising about 0.01 to about 15% by weight of the composition of 12-hydroxystearic acid, about 0.1 to about 30% by weight of the composition of a nonionic surfactant, and about 0.05% to about 10% of a thickening polymer.

[0010] WO 09138801 (NB LABS LIMITED) discloses a skin anti-aging composition comprising a skin cell synthesis promoter, a skin cell activator, and a skin cell cleanser together with cosmetically acceptable excipients. This composition can be formulated as a two-part formulation. [Prior art documents] [Patent documents]

[0011] [Patent Document 1] U.S. Patent Application Publication No. 2018 / 325804 [Patent Document 2] U.S. Patent Application Publication No. 2022218594 [Patent Document 3] European Patent Application Publication No. 2637636 [Patent Document 4] International Publication No. 09138801 [Non-patent literature]

[0012] [Non-Patent Document 1] Database GNPD (online); Mintel; January 6, 2021, "15 Vitamin C + Hyaluronic acid", XP093011390, Database Accession Number 8382495 [Non-patent document 2] Database GNPD (online); Mintel; August 21, 2022, "Clarifying facial cleanser", XP093041221, Database Accession Number 9832656 Summary of the Invention [Problem to be solved by the invention]

[0013] It is therefore an object of the present invention to increase ATP levels in the skin, resulting in a vibrant and radiant skin.

[0014] Another object of the present invention is to provide the above benefits from a wash-off composition. [Means for solving the problem]

[0015] A first aspect of the present invention relates to the use of a composition comprising (i) vitamin C or a derivative thereof and (ii) vitamin E or a derivative thereof to increase adenosine triphosphate (ATP) levels in the skin compared to a composition that does not comprise vitamin C or a derivative thereof and does not comprise vitamin E or a derivative thereof, Vitamin C or a derivative thereof is selected from the group comprising ascorbic acid, salts of ascorbic acid, oxidized and reduced forms of vitamin C, sodium ascorbyl phosphate, 3-O-ethyl ascorbic acid, ascorbyl methylsilanol pectin, magnesium ascorbyl phosphate, ascorbyl glucoside, tetrahexyldecyl ascorbate, ascorbyl aminopropyl phosphate, ascorbyl palmitate, and mixtures thereof; and Vitamin E or a derivative thereof is selected from the group comprising α-, β-, γ-, and σ-tocopherols, their related corresponding tocotrienols, and mixtures thereof; Regarding use.

[0016] Another aspect of the present invention is a cleansing composition comprising: (i) 0.00001 to 0.002% by weight of vitamin C or a derivative thereof; (ii) 0.00001 to 0.002% by weight of vitamin E or a derivative thereof; (iii) 1 to 80 wt. % of an anionic surfactant, and (iv) 10 to 90% by weight of water The present invention relates to a cleansing composition comprising: DETAILED DESCRIPTION OF THE INVENTION

[0017] These and other aspects, features, and advantages will become apparent to those skilled in the art upon reading the following detailed description and the appended claims. For the avoidance of doubt, any feature of one aspect of the present invention may be utilized in any other aspect of the present invention. The term "comprising" is intended to mean "including," but not necessarily "consisting of" or "composed of." In other words, the listed steps or options need not be exhaustive. It should be noted that the examples given in the following description are intended to clarify the invention, but are not intended to limit the invention to those examples themselves. Similarly, unless otherwise indicated, all percentages are weight / weight percentages. Except in the operating examples and comparative examples, or unless otherwise expressly stated, all numbers in the specification and claims expressing amounts of materials or reaction conditions, physical properties of materials and / or uses should be understood to be modified by the term "about." Numerical ranges expressed in the form "from x to y" are understood to include x and y. When multiple preferred ranges for a particular feature are listed in the format "x to y," it is understood that all ranges combining the different endpoints are also contemplated.

[0018] A first aspect of the present invention relates to the use of a composition comprising (i) vitamin C or a derivative thereof and (ii) vitamin E or a derivative thereof to impart a vibrant and radiant glow to the skin. This use is preferably non-therapeutic. This advantage is realized by including these ingredients in the composition at very low concentrations. Vitamin C or a derivative thereof is preferably present in an amount of 0.00001 to 0.002% by weight of the composition. Vitamin E or a derivative thereof is preferably present in an amount of 0.00001 to 0.002% by weight of the composition.

[0019] The composition contains vitamin C or its derivatives. Vitamin C (ascorbic acid, ascorbate) is a simple, low-molecular-weight carbohydrate that is essential to the body as a water-soluble vitamin. Vitamin C, an antioxidant, exists in both oxidized and reduced forms, i.e., L-dehydroascorbic acid and L-ascorbic acid.

[0020] Vitamin C plays a physiological role in the skin, participating in the formation of the skin barrier and collagen in the dermis, against skin oxidation, in preventing wrinkle aging, and in the cell signaling pathways of cell growth and differentiation related to the occurrence and development of various skin diseases.

[0021] Vitamin C or its derivatives that may be used in the present invention may be one or more of the following:

[0022] Sodium Ascorbyl Phosphate: Sodium ascorbyl phosphate is an active and stable vitamin C derivative ingredient for the cosmetic industry. It releases vitamin C in the skin, protects skin cells, promotes collagen formation, controls the formation of senile keratosis, and lightens dark skin.

[0023] 3-O-Ethyl ascorbic acid: 3-O-Ethyl ascorbic acid stimulates collagen production, which significantly improves skin cell structure and the overall condition of the skin.

[0024] Ascorbyl Methylsilanol Pectin: Ascorbyl methylsilanol pectin is a known antioxidant and is known to help improve skin texture and reduce the appearance of aging and pigmentation spots.

[0025] Magnesium ascorbyl phosphate (MAP): Magnesium ascorbyl phosphate (MAP) has all the functions of vitamin C and is very stable. Magnesium ascorbyl phosphate has excellent antioxidant and protective benefits, is effective against UV radiation, and promotes collagen production. This product is recommended for whitening / toning applications, as well as anti-aging and anti-wrinkle products.

[0026] Ascorbic acid: Vitamin C (L-ascorbic acid), USP (United States Pharmacopoeia Grade) is the naturally occurring, active form of vitamin C. Ascorbic acid is a powerful antioxidant (shown to be able to protect skin from oxidative damage). Ascorbic acid can improve the appearance of aging, damaged skin. It is widely used as an added ingredient in skin-toning products to repair hyperpigmentation and age spots. [ka]

[0027] Ascorbyl Glucoside: Ascorbyl glucoside is a water-soluble vitamin C derivative with excellent stability. It is resistant to degradation and has the same toning, sun protection, and anti-aging properties as ascorbic acid.

[0028] Tetrahexyldecyl Ascorbate: Tetrahexyldecyl ascorbate is a very stable, oil-soluble vitamin C ester, but has no inherent antioxidant capacity because all hydroxyl groups are esterified.

[0029] Tetrahexyldecyl ascorbate has excellent skin penetration, resulting in high cellular protection against UV-B radiation. Tetrahexyldecyl ascorbate can improve the appearance of aging, damaged skin. Tetrahexyldecyl ascorbate is widely used as an additive ingredient in skin tone-up products to repair hyperpigmentation and age spots.

[0030] Aminopropyl ascorbyl phosphate: Aminopropyl ascorbyl phosphate is a stabilized vitamin C derivative. Aminopropyl ascorbyl phosphate is ideal for whitening, anti-wrinkle, and antioxidant applications.

[0031] Vitamin C or a derivative thereof is preferably contained in an amount of 0.00001 to 0.002% by weight, more preferably 0.0001 to 0.0015% by weight of the composition.

[0032] Tocopherol acetate or alpha-tocopherol acetate is commonly known as vitamin E. Tocopherol acetate has the following structure: [ka]

[0033] Alpha-tocopherol acetate, also known as tocopherol acetate, is a synthetic form of vitamin E. Alpha-tocopherol acetate is a fat-soluble form of vitamin E and is considered to be the most stable and active form of vitamin E. Alpha-tocopherol acetate is known for its antioxidant properties, protecting cells from oxidative stress-induced damage.

[0034] Tocopheryl acetate is found in many skin care products and is used as a skin conditioning agent in these products. Its antioxidant effects help prevent skin damage caused by excessive exposure to ultraviolet (UV) radiation emitted from the sun. This product is recommended for whitening / toning applications, as well as anti-aging and anti-wrinkle products.

[0035] d-α-Tocopherol acetate has the following structure: [ka]

[0036] d-α-Tocopherol acetate is a chemical closely related to α-tocopherol acetate, a natural active component of vitamin E that also has antioxidant properties, reducing oxidative stress-induced damage in cells.

[0037] d-α-Tocopherol succinate [ka]

[0038] d-α-Tocopherol succinate is a fat-soluble vitamin and one of the most potent antioxidant tocopherols. Its antioxidant properties help reduce oxidative stress-induced damage in cells.

[0039] Vitamin E or its derivatives are available from BASF and Matrix Lifescience, which markets these materials under the names Copherol® 1250 and Vitamin E acetate Care.

[0040] The inventors do not fully understand the reasons behind the synergistic interaction between vitamin E and vitamin C or its derivatives that results in the benefits of the present invention. The extent of the inventors' scientific understanding of these actives and their physiological activities is summarized below.

[0041] Mitochondria are known as the energy powerhouses of cells, producing the majority of ATP within the cell. Exposure to external factors such as UV rays and pollution induces reactive oxygen species (ROS) within cells, leading to oxidative stress. Excessive ROS cause cellular damage and affect mitochondrial function, thereby reducing ATP synthesis. Furthermore, ROS, such as superoxide, singlet oxygen, and peroxide, are also produced during cellular respiration and metabolism under normal conditions, and these, if not quenched by antioxidants, can also lead to undesirable consequences. Vitamin C is a water-soluble vitamin with potent antioxidant properties. Apart from its direct antioxidant function, vitamin C also increases endogenous antioxidant enzymes within cells, reducing oxidative stress-induced damage. Therefore, vitamin C counteracts the effects of oxidative stress-induced damage through its direct antioxidant mechanism and by enhancing the cellular antioxidant system, thereby improving cellular ATP levels. Vitamin E is a lipid-soluble antioxidant and is used as an important ingredient in many cosmetic products. Vitamin E protects the skin from various harmful effects caused by UV exposure by acting as a free radical scavenger. Numerous studies have suggested that vitamin E has antitumor and photoprotective properties. As a fat-soluble antioxidant, vitamin E plays a key role in mitochondrial membranes, reacting more quickly with peroxyl radicals and protecting the membrane from excessive oxidative damage, thereby enhancing mitochondrial function. These unique functions of vitamin C and vitamin E in reducing oxidative stress and enhancing mitochondrial function may provide synergistic benefits in enhancing ATP levels.

[0042] This advantage can be further enhanced if the composition further contains hydroxystearic acid. Preferably, the hydroxystearic acid is 10-hydroxystearic acid, 12-hydroxystearic acid, trihydroxystearic acid (e.g., 9,10,13-trihydroxystearic acid), or trihydroxystearin, or a compound that generates one or more molecules of hydroxystearic acid or hydroxystearate upon decomposition, such as a mono-, di-, or triester of glycerol and hydroxystearic acid. Among these, 10-hydroxystearic acid, 12-hydroxystearic acid, and 9,10,13-trihydroxystearic acid are more preferred, and 12-hydroxystearic acid (12-HSA) is the most preferred. 12-HSA has the following structure: [ka]

[0043] The hydroxystearic acid is contained in an amount of preferably 0.001 to 1% by weight, more preferably 0.01 to 1% by weight, and even more preferably 0.1 to 0.5% by weight of the composition.

[0044] The compositions of the present invention may contain a humectant, typically a polyhydric alcohol. Preferably, the humectant is at least one of propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isoprene glycol, 1,3-propanediol, pentylene glycol, hexylene glycol, 1,2,6-hexanetriol, glycerol, ethoxylated glycerol, and propoxylated glycerol. Preferred humectants are selected from one or more of glycerin, 1,3-butylene glycol, propylene glycol, 1,3-propanediol, pentylene glycol, hexylene glycol, and sorbitol. Glycerol is the most preferred humectant. The amount of humectant is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight, of the composition.

[0045] The topical compositions of the present invention are intended for use in personal care or cosmetic applications and may also be referred to as personal care or cosmetic compositions. As used herein, "personal care composition" is intended to include compositions for topical application, i.e., compositions for the external surfaces of human skin and / or hair. Such compositions can be classified as leave-on or wash-off and include any product applied to the human body to improve appearance, cleansing, odor control, or general aesthetics. The compositions are preferably wash-off cleansing compositions containing a surfactant. The surfactant is preferably an anionic surfactant, preferably a soap. The anionic surfactant preferably comprises 1 to 80% by weight of the composition.

[0046] As used herein, "skin" is intended to include the skin of the face and body (e.g., neck, chest, back, arms, armpits, hands, legs, and scalp), especially exposed areas thereof.

[0047] The composition of the present invention can also be incorporated into the form for cleaning the local surface of human or animal body.Cleansing composition is so-called wash-off form or rinse-off form.These forms are intended to be generally diluted with water, applied to local surface, for example, skin or hair, and then rinsed off with sufficient amount of water after a few minutes.Cleansing composition can be any form, either solid form or liquid form.When in solid form, cleansing composition is preferably a bar, which can contain soap, synthetic anionic surfactant, or the combination of these two.

[0048] The soap for preparing the cleansing composition of the present invention is preferably C8 to C 24 Soap, preferably C 10 ~C 20 Soap, most preferably C 12 ~C 18 The soap is a soap. The cation of the soap can be an alkali metal, an alkaline earth metal, or ammonium. Preferably, the cation of the soap is selected from sodium, potassium, or ammonium. More preferably, the cation of the soap is sodium or potassium. Fatty acids derived from other suitable fats and oils, such as peanut, soybean, tallow, palm, palm kernel, etc., can also be used in other desired proportions.

[0049] Synthetic anionic surfactants for use in wash-off compositions are preferably selected from alkyl ether sulfates, primary alkyl sulfates, secondary alkyl sulfonates, alkyl benzene sulfonates, or ethoxylated alkyl sulfates. Preferred non-soap anionic surfactants in cleansing compositions are alkyl ether sulfates derived from either natural or synthetic sources, preferably alkyl ether sulfates having 1 to 3 ethylene oxide groups, and / or sulfonic acids. Sodium lauryl ether sulfate is particularly preferred. Alkyl polyglucosides, preferably those having a carbon chain length of C6 to C8, are also preferred. 16 An alkyl polyglucoside, which is

[0050] When present, the anionic surfactant is preferably present in an amount of 1 to 80% by weight of the cleansing composition, preferably 10 to 85% by weight, more preferably 25 to 75% by weight. The cleansing composition is preferably in solid or semi-solid form, most preferably in solid form. A preferred solid composition is in the form of a bar soap.

[0051] Preferred solid cleansing compositions may contain other known ingredients, such as fragrances, pigments, preservatives, emollients, sunscreens, gelling agents, and thickeners. Water is a preferred carrier. When present, water is preferably present in an amount of at least 1% by weight of the composition, more preferably at least 2% by weight, and even more preferably at least 5% by weight. When water is the carrier, preferred cleansing compositions contain 10-50% by weight, more preferably 12-40% by weight, and most preferably 12-22% by weight of water.

[0052] The cleansing compositions of the present invention can also be delivered via moisturizing bars or moisturizing liquid compositions. Moisturizing bar compositions containing fatty acyl isethionates (e.g., cocoyl isethionates) are particularly preferred. Fatty acyl isethionate (e.g., cocoyl isethionate) surfactant "products" are defined as mixtures of anionic acyl isethionate surfactants with fatty acids / fatty acid soaps. These products are highly desirable in personal care skin cleansing or hair cleansing products, particularly personal care products, due to their high lathering, mild skin irritation, and excellent emollient properties. Typically, fatty acid isethionate surfactant products are produced by esterification of fatty acids or by the reaction of isethionates with fatty acid chlorides having carbon chain lengths of C8 to C20. A typical surfactant product containing fatty acyl isethionates typically contains about 40-95% by weight of acid isethionate and 5-50%, typically 10-40%, by weight of free fatty acid, in addition to less than 5% isethionate salt and trace amounts (less than 2%) of other additives. Fatty acid soaps may be present in the range of 5-15% by weight. Other surfactants, such as betaines, may be present at 1-5% by weight. Water generally comprises 2-8% by weight of the composition.

[0053] Liquid wash-off compositions generally contain a low concentration of surfactant and are gentle on the skin. The surfactant generally comprises 4 to 18% by weight, preferably 6 to 12% by weight, of the liquid cleansing composition. Surfactants for inclusion in the liquid cleansing composition of the present invention may preferably be anionic, nonionic, cationic, or amphoteric. A useful surfactant for inclusion in the liquid cleansing composition of the present invention is sodium lauryl ether sulfate (SLES). The SLES used in the present invention generally preferably has 1 to 3 ethoxylate (EO) groups. SLES is preferably present in an amount of 3 to 8% by weight of the composition. Another surfactant that may be included in the present invention is cocamide monoethanolamine (CMEA). CMEA is preferably present in an amount of 1 to 3% by weight of the composition. A preferred embodiment of the liquid cleansing composition of the present invention relates to an embodiment in which the surfactant comprises a mixture of sodium lauryl ether sulfate (SLES) and cocamide monoethanolamine (CMEA). Another useful surfactant for inclusion in the liquid cleansing compositions of the present invention is an amphoteric surfactant, preferably a betaine surfactant, more preferably an alkylamidopropyl betaine surfactant, such as cocamidopropyl betaine. In a preferred embodiment, the composition comprises 0.1 to 5 wt. %, preferably 0.5 to 4 wt. %, more preferably 1 to 3 wt. % of a betaine surfactant.

[0054] Nonionic classes of surfactants for inclusion in the liquid cleansing compositions of the present invention are preferably the polyoxyethylene sorbitan alkyl ester class (sold as Tween surfactants), fatty alcohol ethoxylates (sold as Brij surfactants), alkylphenol ethoxylates (sold as Triton surfactants), fatty acid ethoxylates (sold as Myrj surfactants), and alkyl polyglucosides (sold as Plantacare surfactants).

[0055] Water is the preferred carrier in the liquid cleansing compositions of the present invention, in which water is generally present in an amount of 70 to 95% by weight.

[0056] The composition may further contain a free fatty acid other than hydroxystearic acid. The free fatty acid is preferably present in an amount of 0.01 to 5% by weight of the composition. The free fatty acid may be one or more of C8 to C24, preferably C10 to C20, and most preferably C12 to C18 fatty acids. The free fatty acid may be present in the final product as an unsaponified fatty acid.

[0057] Preferred liquid cleansing compositions may contain other known ingredients such as electrolytes, fragrances, pigments, preservatives, emollients, sunscreens, emulsifiers, gelling agents, and thickeners.

[0058] Another aspect of the present invention relates to a method for imparting a vibrant glow to skin, comprising the steps of (i) applying to said skin a cleansing composition of the present invention, preferably diluted with water, followed by (ii) rinsing said skin with water.

[0059] The method is preferably cosmetic or non-therapeutic.

[0060] Yet another aspect of the present invention relates to the use of a combination of vitamin C or a derivative thereof and vitamin E or a derivative thereof to enhance ATP levels in HDFa cells.

[0061] 1. Use of a composition comprising (i) vitamin C or a derivative thereof and (ii) vitamin E or a derivative thereof to increase adenosine triphosphate (ATP) levels in the skin compared to a composition that does not contain vitamin C or a derivative thereof and does not contain vitamin E or a derivative thereof, Vitamin C or a derivative thereof is selected from the group comprising ascorbic acid, salts of ascorbic acid, oxidized and reduced forms of vitamin C, sodium ascorbyl phosphate, 3-O-ethyl ascorbic acid, ascorbyl methylsilanol pectin, magnesium ascorbyl phosphate, ascorbyl glucoside, tetrahexyldecyl ascorbate, ascorbyl aminopropyl phosphate, ascorbyl palmitate, and mixtures thereof; and Vitamin E or a derivative thereof is selected from the group comprising α-, β-, γ-, and σ-tocopherols, their related corresponding tocotrienols, and mixtures thereof; use.

[0062] The composition preferably contains 0.00001 to 0.002% by weight of vitamin C or a derivative thereof.

[0063] The composition preferably contains 0.00001 to 0.002% by weight of vitamin E or a derivative thereof.

[0064] Preferably, the composition further comprises 0.001 to 1% by weight of hydroxystearic acid.

[0065] Preferably, the hydroxystearic acid is 12-hydroxystearic acid.

[0066] Preferably, the composition is a cleansing composition that includes a surfactant.

[0067] Preferably, the surfactant comprises an anionic surfactant, preferably a soap.

[0068] The anionic surfactant preferably accounts for 1 to 80% by weight of the composition.

[0069] Preferably, the composition comprises a humectant, preferably glycerol.

[0070] The present invention provides a cleansing composition comprising: 0.00001 to 0.002% by weight of vitamin C or a derivative thereof; 0.00001 to 0.002% by weight of vitamin E or a derivative thereof; 1 to 80% by weight of an anionic surfactant, and 10 to 90% by weight of water A cleansing composition is provided, comprising:

[0071] Preferably, the composition further comprises 0.001 to 1% by weight of hydroxystearic acid.

[0072] It is preferable that the composition further contains 0.01 to 5% by weight of a free fatty acid other than the hydroxystearic acid.

[0073] Preferably, the composition further comprises a humectant, preferably glycerol.

[0074] The present invention provides a method for increasing adenosine triphosphate (ATP) levels in the skin, comprising the steps of: (i) applying to the skin a composition according to any one of claims 10 to 13, preferably diluted with water; and (ii) rinsing the skin with water.

[0075] The invention will now be illustrated by way of the following non-limiting examples.

[0076] [Example] [Examples A-F and 1-3] Interaction between Vitamin C and Vitamin E to Produce Synergistic ATP Levels The individual active substances and combinations of active substances shown below in Table 1 were prepared and tested for ATP levels in HDFa cells using the protocol shown below.

[0077] Human dermal fibroblasts (HDFa) were seeded into 96-well plates and maintained at 37°C in a 5% CO2 incubator for 24 hours. Cells were then treated with various concentrations of vitamin C (VC) or vitamin E (VE), or a combination of VC and VE, using fresh medium, and incubation continued for 1 hour. After 1 hour of incubation, cells were lysed by adding 30 μl of RIPA buffer containing protease / phosphatase inhibitors. Cell lysates were used to estimate ATP levels using an ATP measurement kit. ATP data were normalized to total protein from each treatment, and ATP levels were measured with and without treatment.

[0078] The measured ATP levels are also shown in Table 1. [Table 1]

[0079] The data in Table 1 above show that at all concentrations (0.01-1 ppm), the combination of vitamin C and vitamin E is superior to the individual actives at the same concentration, thereby demonstrating synergistic activity.

[0080] The cleansing compositions shown in Table 2 below have been found to be useful in providing vibrant radiance in accordance with the present invention. [Table 2]

Claims

1. 1. Use of a composition comprising (i) vitamin C or a derivative thereof and (ii) vitamin E or a derivative thereof to increase adenosine triphosphate (ATP) levels in the skin compared to a composition that does not contain vitamin C or a derivative thereof and does not contain vitamin E or a derivative thereof, Vitamin C or a derivative thereof is selected from the group comprising ascorbic acid, salts of ascorbic acid, oxidized and reduced forms of vitamin C, sodium ascorbyl phosphate, 3-O-ethyl ascorbic acid, ascorbyl methylsilanol pectin, magnesium ascorbyl phosphate, ascorbyl glucoside, tetrahexyldecyl ascorbate, ascorbyl aminopropyl phosphate, ascorbyl palmitate, and mixtures thereof; and Vitamin E or a derivative thereof is selected from the group comprising α-, β-, γ-, and σ-tocopherols, their related corresponding tocotrienols, and mixtures thereof; use.

2. 2. The use according to claim 1, wherein the vitamin C or a derivative thereof is contained in an amount of 0.00001 to 0.002% by weight of the composition.

3. 3. The use according to claim 1, wherein the vitamin E or a derivative thereof is contained in an amount of 0.00001 to 0.002% by weight of the composition.

4. The use according to any one of claims 1 to 3, wherein the composition further comprises 0.001 to 1% by weight of hydroxystearic acid.

5. The use according to claim 4, wherein the hydroxystearic acid is 12-hydroxystearic acid.

6. The use according to any one of claims 1 to 5, wherein the composition is a cleansing composition comprising a surfactant.

7. 7. The use according to claim 6, wherein the surfactant comprises an anionic surfactant, preferably a soap.

8. The use according to claim 7, wherein the anionic surfactant comprises 1 to 80% by weight of the composition.

9. 9. Use according to any one of claims 1 to 8, comprising a moisturising agent, preferably glycerol.

10. 1. A cleansing composition comprising: (i) 0.00001 to 0.002% by weight of vitamin C or a derivative thereof; (ii) 0.00001 to 0.002% by weight of vitamin E or a derivative thereof; (iii) 1 to 80% by weight of an anionic surfactant, and (iv) 10 to 90% by weight of water A cleansing composition comprising:

11. The composition of claim 10 further comprising 0.001 to 1% by weight of hydroxystearic acid.

12. The composition of claim 11, further comprising 0.01 to 5% by weight of a free fatty acid other than said hydroxystearic acid.

13. 13. The composition according to any one of claims 10 to 12, further comprising a humectant, preferably glycerol.

14. 14. A method of increasing adenosine triphosphate (ATP) levels in the skin, comprising the steps of: (i) applying to the skin a composition according to any one of claims 10 to 13, preferably diluted with water; and (ii) rinsing the skin with water. A method comprising:

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